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SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Pathogens
Yazar(lar) :
Firas A. Rabi , Mazhar S. Al Zoubi , Ghena A. Kasasbeh , Dunia M. Salameh , Amjad D. Al-Nasser
Yıl :
2020
Firas A. Rabi
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Kaydet Alıntıla
In December 2019, a cluster of fatal pneumonia cases presented in Wuhan, China. They were caused by a previously unknown coronavirus. All patients had been associated with the Wuhan Wholefood market, where seafood and live animals are sold. The virus spread rapidly and public health authorities in China initiated a containment effort. However, by that time, travelers had carried the virus to many countries, sparking memories of the previous coronavirus epidemics, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and causing widespread media attention and panic. Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. Here we present a summary of current knowledge regarding the novel coronavirus and the disease it causes.
DOI : 10.3390/pathogens9030231
Anahtar Kelimeler : coronavirus, covid-19, sars-cov-2, wuhan, pandemic
ISSN: 2076-0817
Cilt: 9
Sayı: 3
Sayfa: 231
Sınıflandırma :
2
Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Nutrients
Yazar(lar) :
Hamid A. Bakshi , Mazhar S Al Zoubi , Hakkim L. Faruck , Alaa A A Aljabali , Firas A. Rabi , Amin A. Hafiz , Khalid M Al-Batanyeh , Bahaa Al-Trad , Prawej Ansari , Mohamed M. Nasef , Nitin B. Charbe , Saurabh Satija , Meenu Mehta , Vijay Mishra , Gaurav Gupta , Salem Abobaker , Poonam Negi , Ibrahim M. Azzouz , Ashref Ali K Dardouri , Harish Dureja , Parteek Prasher , Dinesh K. Chellappan , Kamal Dua , Mateus Webba Da Silva , Mohamed El Tanani , Paul A. McCarron , Murtaza M. Tambuwala
Yıl :
2020
Firas A. Rabi
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
DOI : 10.3390/nu12061901
Anahtar Kelimeler : pancreatic cancer, crocin, apoptosis, cell cycle, radiation, hepatic injury
ISSN: 2072-6643
Cilt: 12
Sayı: 1901
Sayfa: 1901
Sınıflandırma :
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