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Varicella zoster virus transmission in youth during incarceration
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
International Journal of Prisoner Health
Yayıncı:
Emerald Publishing
Yazar(lar) :
Danusia Moreau , Jonathan Besney , Angela Jacobs , Dan Woods , Mark Joffe , Rabia Ahmed
Konu :
Health and Social Care
Yıl :
2016
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Facility-based Varicella zoster virus (VZV) transmission is reported in a Canadian youth offender correctional centre (YOCC). Transmission occurred from an immunocompetent youth offender (YO) with localized Herpes zoster to another immunocompetent single dose vaccinated YO, resulting in Varicella zoster (VZ) breakthrough disease. The purpose of this paper is to identify infection prevention and control (IPAC) measures utilized in this setting. Design/methodology/approach A retrospective chart and immunization record review was conducted for two VZV cases and 27 exposed YO contacts in order to obtain demographic, clinical and immunization data. Descriptive data analysis was performed. Findings All VZV cases and exposed contacts were male with an average age of 14.2 and 15.6 years for cases and contacts, respectively. Both cases shared the same living unit in the YOCC. There were 28 identified YO contacts, of whom 70 percent were single dose vaccinated with univalent vaccine, followed by 22 percent with a previous history of Varicella disease. All cases and contacts were born in Canada. No foreign-born populations were involved with this event. Infection control measures included additional precaution management, enhanced surveillance and environmental cleaning. As such, no hospitalizations or post-exposure immunizations were required. Originality/value This report highlights the role that VZ breakthrough disease could play in fueling an outbreak in a high-risk environment without rapid recognition and implementation of preventative measures. It also underscores the importance of IPAC presence and public health immunization programs within correctional centers to avoid infectious disease threats.
DOI : 10.1108/IJPH-11-2015-0038
Anahtar Kelimeler : Canada, Youth, Control, Transmission, Infection, Varicella
ISSN: 1744-9200
Cilt: 12
Sayı: 2
Sayfa: 106-114
Sınıflandırma :
Viroloji %99
2
Abu Dhabi - New vaccination against rotavirus for babies in Abu Dhabi
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
International Journal of Health Care Quality Assurance
Yayıncı:
Emerald Publishing
Konu :
Health Care Management / Healthcare
Yıl :
2013
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1108/IJHCQA.06226haa.010
Anahtar Kelimeler : Vaccination programmes in Abu Dhabi, Rotavirus infection and immunisations of babies, Public healthcare programmes
ISSN: 0952-6862
Cilt: 26
Sayı: 8
Sayfa: -
Sınıflandırma :
Viroloji %99
3
Human influenza: a virus classification using a probabilistic neural network
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Kybernetes
Yayıncı:
Emerald Publishing
Yazar(lar) :
Zheng Kou , Yanhong Zhou , Xiaoli Qiang
Konu :
Electrical and Electronic Engineering
Yıl :
2008
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The traditional method to distinguish the serotype of influenza A virus was based on the antigen reaction of HA and NA with their antibodies. The antibody of specific subtype virus was difficult to get and the reaction was not easy to be done. To be a complementation to the traditional classification methods based on the serological reaction, aims to present a novel method for viral classification. Design/methodology/approach The similarity values of all subtype HA genes in vector space were considered and classified using a probabilistic neural network (PNN). The PNN model was trained by the 132 viral sequences in the training set and the classification quality was examined using 28 viral sequences in the testing set. Findings A novel technique for the serotype classification of influenza A virus isolated from human was proposed in the paper. The system achieved 100 per cent accuracy with all serotypes of human influenza A virus. Research limitations/implications The time for the large‐scale calculations of the average similarity based on multisequence alignment is the main limitation. Practical implications This is a supplementation to the traditional virology research. Originality/value The novel classification method based on the similarity of viral nucleotide sequences and the PNN model would be useful for the epidemic supervision and prevention.
DOI : 10.1108/03684920810907733
Anahtar Kelimeler : Neural nets, Immunologic diseases, Cybernetics
ISSN: 0368-492X
Cilt: 37
Sayı: 9%2F10
Sayfa: 1425-1430
Sınıflandırma :
Viroloji %76
4
Prevalence of Hepatitis B virus and/or Hepatitis C virus co‐infections in prisoners infected with the Human Immunodeficiency Virus
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
International Journal of Prisoner Health
Yayıncı:
Emerald Publishing
Yazar(lar) :
Emanuele Pontali , Franco Ferrari
Konu :
Health and Social Care
Yıl :
2008
Yayıncı Web Sitesi
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Kaydet Alıntıla
Correctional facilities host a disproportionately high prevalence of HBV, HCV and HIV infection. We evaluated the prevalence of HBV and/or HCV co‐infection among HIV‐infected inmates entering our correctional facility. Over a 30‐month period, 173 consecutive HIV‐infected inmates entered our institution and were evaluated. HCV co‐infection was observed in more than 90% of the tested HIV‐infected inmates, past HBV infection in 77.4% and active HBV co‐infection in 6.7%; triple coinfection (HIV, HCV and HBs‐Ag positivity) was seen in 6.1% of them. Given the observed high prevalence of co‐infection, testing for HBV and HCV in all HIV‐infected inmates at entry in any correctional system is recommended to identify those in need of specific care and/or preventing interventions.
DOI : 10.1080/17449200802038207
Anahtar Kelimeler : Hepatitis B, Hepatitis C, HIV
ISSN: 1744-9200
Cilt: 4
Sayı: 2
Sayfa: 77-82
Sınıflandırma :
5
Inactivation studies on BSE agent
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
British Food Journal
Yayıncı:
Emerald Publishing
Yazar(lar) :
David M. Taylor
Konu :
Industry and Public Sector Management
Yıl :
1996
Yayıncı Web Sitesi
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Kaydet Alıntıla
Transmissible degenerative encephalopathy agents are relatively resistant to standard decontamination procedures. Bovine spongiform encephalopathy (BSE) agent was inactivated by sodium hypochlorite but not sodium dichloroisocyanurate; 1M or 2M sodium hydroxide was unreliable for BSE and scrapie agents. BSE infectivity survived a two‐year exposure to formol saline. Porous‐load autoclaving at 134‐138°C was ineffective with BSE and scrapie agents, and resistance to porous‐load autoclaving was enhanced by prior exposure to ethanol. Gravity displacement autoclaving at 132°C was also ineffective with BSE agent. Gravity displacement autoclaving at 121°C was effective with scrapie agent if it was exposed to 2M sodium hydroxide during autoclaving. After BSE‐spiked material was processed through facsimiles of EC rendering processes, infectivity was recoverable in the meat and bonemeal produced by four of these processes. Using scrapie‐spiked material, infectivity was recoverable in all meat and bonemeal samples except those derived from processes which used steam under pressure.
DOI : 10.1108/00070709610153678
Anahtar Kelimeler : BSE, European Union, Meat, Process control
ISSN: 0007-070X
Cilt: 98
Sayı: 11
Sayfa: 36-39
Sınıflandırma :
Viroloji %86
6
Protective effects of blueberry against hydrogen peroxide-induced oxidative stress in HEPG2 cells
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
British Food Journal
Yayıncı:
Emerald Publishing
Yazar(lar) :
Huailing Wang , Jie Liu , Xiaoyu Liu , Zhigang Liu
Konu :
Industry and Public Sector Management
Yıl :
2019
Yayıncı Web Sitesi
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Kaydet Alıntıla
Blueberry contains bioactive compounds which are beneficial to organisms, such as phenolics and flavonoids. The purpose of this paper is to evaluate the potential protective effects of blueberry extracts (BE) on H2O2-induced HepG2 cells. Design/methodology/approach Cell protection was evaluated via the survivals of the cell. Reactive oxygen species (ROS) level, antioxidant enzyme and malondialdehyde (MDA) were detected. Western blot was carried out to analysis protein which was related to the cell apoptosis pathway. Changes in morphology including: cell total apoptosis/necrosis and G0/G1 cycle arresting were also concomitant. Findings The levels of ROS and malondialdehyde (MDA) reduced after the BE treatment while the contents of superoxide dismutase, and glutathione peroxidase (GSH-Px) increased in HepG2 cells induced by H2O2. Furthermore, mechanistic studies indicated that BE regulated the activation of mitochondrial apoptosis signal-regulating (Bcl-2, Bax). Qu was used as a positive control group. All these results demonstrated that the BE have a potential against oxidative stress in vitro. Originality/value Few studies have focused on the bioactivities of blueberry on oxidative stress. Taken together, the results confirm that polyphenol-enriched BE have the ability to protect against oxidative stress in cells. It has a great potential as a functional food ingredient to health benefits. Furthermore, this work showed the value of using simple biological models to screen for compounds that are of interest for food and pharmacological industry.
DOI : 10.1108/BFJ-07-2018-0434
Anahtar Kelimeler : ROS, Apoptosis, Blueberry extracts, H2O2, Oxidative stress
ISSN: 0007-070X
Cilt: 121
Sayı: 11
Sayfa: 2809-2820
Sınıflandırma :
Apoptoz %48
Viroloji %43
7
Immunoprophylaxis against respiratory syncytial virus (RSV) with palivizumab in children: a systematic review and economic evaluation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Clinical Governance: An International Journal
Yayıncı:
Emerald Publishing
Konu :
Health Care Management / Healthcare
Yıl :
2009
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DOI : 10.1108/cgij.2009.24814bab.004
ISSN: 1477-7274
Cilt: 14
Sayı: 2
Sayfa: -
Sınıflandırma :
Biyotıp %100
Viroloji %100
8
Recent advances in sensors for early detection of pathogens causing rheumatic heart disease
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
Emerald Publishing
Kaynak 2:
Emerald Publishing
Dergi:
Sensor Review
Yayıncı:
Emerald
Yazar(lar) :
Swati Singh , Ankur Kaushal , Ashok Kumar
Yıl :
2018
Tam Metin
Kaydet Alıntıla
There is an immense concern in the international community about controlling the outburst of infectious diseases. An essential step towards diminishing it is the development of an adequate detection system. Among the huge plethora of microorganisms which may infect the human body, Streptococcus pyogenes is important one which infects the upper respiratory tract leading to sore throat, which eventually develops into rheumatic heart disease (RHD) in the absence of timely treatment. A major process in controlling the infection is to detect it at an early stage. Hence, there is a need to develop detection tools which are both rapid and reliable. Design/methodology/approach Different types of diagnostic methods are available for identification, but the most commonly used are culturing, staining and rapid antigen detection tests. For better sensitivity and specificity, this review describes the development of biosensor. Compared with the current available methods, which are usually cumbersome, time-consuming and expensive, this approach features sequence specificity, cost efficiency, rapid and ease of use. Findings This review outlines various sensors which are available for the detection of Streptococcus pyogenes which causes human RHD. The working scheme of the sensors, their sensitivity and limitation of detection has been described in the review. Originality/value The review fulfills an acknowledged the need to study various sensors that are available for the detection of Streptococcus pyogenes, causing human RHD.
DOI : 10.1108/sr-06-2017-0094
Anahtar Kelimeler : DNA sensor, Rheumatic heart disease, S. pyogenes
ISSN: 0260-2288
Sayı: 1
Cilt: 38
Sayfa: 92-98
Sınıflandırma :
9
Solymitana Clades
e-Kitap

e-Kitap
Kaynak 1:
Bodleian Libraries
Kaynak 2:
Bodleian Libraries
Dergi:
University of Oxford
Yayıncı:
University of Oxford
Yazar(lar) :
Thomas Legge
Konu :
Plays
Yıl :
1900
Kaydet Alıntıla
Anahtar Kelimeler : Text
Sınıflandırma :
10
The fight against SARS: a backfilling connection for the prevention of drying out of floor drains' U‐traps
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Structural Survey
Yayıncı:
Emerald Publishing
Yazar(lar) :
K.K. Yuen , Eric W.M. Lee , S.M. Lo
Konu :
Built Environment
Yıl :
2003
Yayıncı Web Sitesi
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Kaydet Alıntıla
Severe acute respiratory syndrome (SARS) was first reported in China in November 2002 and had spread to Hong Kong by late February 2003. Initially hospitals were the main sites of the infection which was thought to be due to an airborne virus. However the spread of the virus to large residential tower blocks led authorities to suspect that the evaporation of toilet floor drain U‐traps may be a possible way of spreading the virus. The paper reports a full scale rig testing of methods to prevent the evaporation of the U‐trap water seals and concludes with recommendations for further research.
DOI : 10.1108/02630800310507122
Anahtar Kelimeler : Viruses, Water supply and waste systems, Public health
ISSN: 0263-080X
Cilt: 21
Sayı: 4
Sayfa: 114-118
Sınıflandırma :
Viroloji %79
11
Trim and chop
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Work Study
Yayıncı:
Emerald Publishing
Konu :
Performance Management and Measurement
Yıl :
2003
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1108/ws.2003.07952bad.006
ISSN: 0043-8022
Cilt: 52
Sayı: 2
Sayfa: -
Sınıflandırma :
12
Personnel Planning to Deal with AIDS in the Workplace
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
International Journal of Manpower
Yayıncı:
Emerald Publishing
Yazar(lar) :
John P. Kohl , Alan N. Miller
Konu :
Economics
Yıl :
1992
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Kaydet Alıntıla
Introduction In September 1991, the Centers for Disease Control reported that, since AIDS (Acquired Immune Deficiency Syndrome) was first diagnosed in 1981, 195,718 active cases have been reported in the United States, with 126,159 of these resulting in death. Health agencies estimate that as many as 1.5 million Americans are already infected with the HIV (AIDS‐causing) virus, and that as many as 250,000 to 300,000 active cases will occur in the US. The World Health Organization estimates that about 10 million people worldwide are now infected with the HIV virus.
DOI : 10.1108/eb045297
ISSN: 0143-7720
Cilt: 13
Sayı: 1
Sayfa: 64-71
Sınıflandırma :
13
Looming cognition for global competition: the approaching avian influenza pandemic
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Asia Pacific Journal of Marketing and Logistics
Yayıncı:
Emerald Publishing
Yazar(lar) :
John Overby , Mike Rayburn , David C. Wyld , Kevin Hammond
Konu :
Marketing
Yıl :
2005
Yayıncı Web Sitesi
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Kaydet Alıntıla
Epidemiologists are concerned the next deadly global cognition will be a new kind of deadly flu which humans have no resistance. Since the 1960s, their alarm has been focused on a bird (avian) virus (H5N1). This virus is generally harmless in its host species, but it is extremely deadly when contracted by humans. H5N1 mutates quickly and tends to pick up genes from flu viruses that affect other species. The flu is far more contagious and harder to contain than the SARS (severe acute respiratory syndrome) virus. It is projected that 30‐40 per cent of the population would be infected in a H5N1 flu pandemic, and as many as one‐third would die. The 1918 Spanish flu caused 20 to 50 million deaths world wide. One scientist observed that the 1918 Spanish flu pandemic could have caused civilisation to disappear within a few weeks. Currently, more than 50 million chickens have been slaughtered in eight Asian countries in efforts to curb the spread of avian influenza. This article examines the roots and dangers of the potential avian influenza pandemic, examining the business and social ramifications that could ensue if the worst case scenario occurs.
DOI : 10.1108/13555850510672322
Anahtar Kelimeler : Avian influenza, Spanish flu, SARS
ISSN: 1355-5855
Cilt: 17
Sayı: 2
Sayfa: 17-30
Sınıflandırma :
14
Selected CDC HIV/AIDS information resources
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Reference Services Review
Yayıncı:
Emerald Publishing
Yazar(lar) :
Brenda W. Garza
Konu :
Library and Information Studies
Yıl :
1991
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Kaydet Alıntıla
June 1981 marked the beginning of an indepth investigation by the Centers for Disease Control (CDC) of clusterings of two rare disorders, Pneumocystis carinii pneumonia and Kaposi's sarcoma, in homosexual men. These diseases were soon recognized as two of the many opportunistic infections and cancers that can attack the immune systems of persons who are infected with human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS).
DOI : 10.1108/eb049123
ISSN: 0090-7324
Cilt: 19
Sayı: 2
Sayfa: 45-46
Sınıflandırma :
15
The Horse Dictionary: English‐language Terms Used in Equine Care, Feeding, Training, Treatment, Racing and Show
Dergi Makalesi

Dergi Makalesi
Kaynak :
Emerald Publishing
Dergi:
Reference Reviews
Yayıncı:
Emerald Publishing
Yazar(lar) :
Sarah Gash
Konu :
Library and Information Studies
Yıl :
2002
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1108/rr.2002.16.3.29.141
Anahtar Kelimeler : Animals
ISSN: 0950-4125
Cilt: 16
Sayı: 3
Sayfa: 29-29
Sınıflandırma :
Viroloji %75
16
Covid19 Identification from Chest X-Ray Images using Local Binary Patterns with assorted Machine Learning Classifiers
Konferans Bildirileri

Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
Sudeep D. Thepade , Ketan Jadhav
Konu :
Aerospace, Bioengineering, Communication, Networking and Broadcast Technologies, Components, Circuits, Devices and Systems, Computing and Processing, Engineered Materials, Dielectrics and Plasmas, Engineering Profession, Fields, Waves and Electromagnetics, General Topics for Engineers, Geoscience, Nuclear Engineering, Photonics and Electrooptics, Power, Energy and Industry Applications, Robotics and Control Systems, Signal Processing and Analysis, Transportation
Yıl :
2020
Yayıncı Web Sitesi
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Kaydet Alıntıla
The novel corona virus caused by the SARS-CoV2 virus originated in Wuhan, China and spread globally. The massive outbreak of the virus resulted in millions of people being infected. Early detection of the virus is crucial in the complete recovery of the patient but can be fatal if detected in the later stages. The symptoms of the virus being similar to flu make it difficult to detect. This paper attempts an automated system for identification of the Covid19 virus infected images of chest X-Ray. The proposed method uses a dataset which has human chest X-Rays of non infected people as well as patients suffering from pneumonia and Covid19 virus infection. Local binary patterns with variations in its input parameters are used for feature extraction. The resulting feature sets are classified using several machine learning algorithms and ensembles of these individual models. Results of experimentation are obtained across 10 fold cross validation testing. Evaluation metrics accuracy, positive predictive value (PPV), sensitivity and f-measure are used to compare performance. Observations of the results show that the ensemble of RTree-RForest-KNN gives the best classification performance while ensemble models perform better than most individual classifiers. Comparing the input parameters of the LBP, the best performance is given by parameters R=6 (P=48) and R=7 (P=56) gives the best performance for the average of metrics for 10 fold cross validation in the proposed Covid19 identification method from chest X-Ray images.
DOI : 10.1109/ibssc51096.2020.9332158
Anahtar Kelimeler : COVID-19, Machine learning algorithms, Machine learning, Feature extraction, Viruses (medical), X-ray imaging, Testing, computerised tomography, decision trees, diseases, feature extraction, image classification, learning (artificial intelligence), medical image processing, microorganisms, nearest neighbour methods, random forests, support vector machines, feature extraction, covid19 identification, China, Wuhan, human chest X-rays, covid19 virus infection, RTree-RForest-KNN, machine learning, SARS-CoV2 virus, novel corona virus, assorted machine learning classifiers, local binary patterns, chest X-ray images, Covid19, Local Binary Pattern, Machine Learning, Histogram
Sınıflandırma :
17
Classifying proteins as extracellular using programmatic motifs and genetic programming
Konferans Bildirileri

Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
J.R. Koza , F.H. Bennett , D. Andre
Konu :
Computing and Processing
Yıl :
1998
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
As newly sequenced proteins are deposited into the world's ever growing archive of protein sequences, they are typically immediately tested by various computerized algorithms for clues as to their biological structure and function. One question about a new protein involves its cellular location-that is, where the protein resides in a living organism (extracellular, intracellular, etc.). A paper by J. Cedano et al. (1997) reported a human-created five way algorithm for cellular location created using statistical techniques with 76% accuracy. The article describes a two way classification algorithm that was evolved using genetic programming with 83% accuracy for determining whether a protein is extracellular. Unlike the statistical calculation, the genetically evolved algorithm employs a large and varied arsenal of computational capabilities, including arithmetic functions, conditional operations, subroutines, iterations, memory, data structures, set creating operations, macro definitions, recursion, etc. The genetically evolved classification algorithm can be viewed as an extension (which we call a programmatic motif) of the conventional notion of a protein motif. The genetically evolved program constitutes an instance of an evolutionary computation technique producing a solution to a problem that is competitive with that produced using human intelligence.
DOI : 10.1109/icec.1998.699503
Anahtar Kelimeler : Proteins, Extracellular, Classification algorithms, Testing, Biology computing, Organisms, Genetic programming, Arithmetic, Data structures, Evolutionary computation, biology computing, proteins, molecular biophysics, genetic algorithms, pattern classification, protein classification, extracellular proteins, programmatic motifs, genetic programming, newly sequenced proteins, protein sequences, computerized algorithms, biological structure, cellular location, living organism, human created five way algorithm, statistical techniques, two way classification algorithm, genetically evolved algorithm, arithmetic functions, conditional operations, subroutines, data structures, set creating operations, macro definitions, genetically evolved classification algorithm, programmatic motif, protein motif, evolutionary computation technique, human intelligence
Sınıflandırma :
Viroloji %98
18
Reassortment Networks and the Evolution of Pandemic H1N1 Swine-Origin Influenza
Dergi Makalesi

Dergi Makalesi
Kaynak :
IEEE Xplore
Dergi:
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Yazar(lar) :
Shahid H. Bokhari , Laura W. Pomeroy , Daniel A. Janies
Konu :
Bioengineering, Computing and Processing
Yıl :
2012
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Prior research developed Reassortment Networks to reconstruct the evolution of segmented viruses under both reassortment and mutation. We report their application to the swine-origin pandemic H1N1 virus (S-OIV). A database of all influenza A viruses, for which complete genome sequences were available in Genbank by October 2009, was created and dynamic programming was used to compute distances between all corresponding segments. A reassortment network was created to obtain the minimum cost evolutionary paths from all viruses to the exemplar S-OIV A/California/04/2009. This analysis took 35 hours on the Cray Extreme Multithreading (XMT) supercomputer, which has special hardware to permit efficient parallelization. Six specific H1N1/H1N2 bottleneck viruses were identified that almost always lie on minimum cost paths to S-OIV. We conjecture that these viruses are crucial to S-OIV evolution and worthy of careful study from a molecular biology viewpoint. In phylogenetics, ancestors are typically medians that have no functional constraints. In our method, ancestors are not inferred, but rather chosen from previously observed viruses along a path of mutation and reassortment leading to the target virus. This specificity and functional constraint render our results actionable for further experiments in vitro and in vivo.
DOI : 10.1109/tcbb.2011.95
Anahtar Kelimeler : Viruses (medical), Bioinformatics, Evolution (biology), Databases, Materials, Genomics, Program processors, biology computing, cellular biophysics, dynamic programming, genetics, genomics, microorganisms, reassortment networks, pandemic H1N1 swine-origin influenza, influenza A viruses, genome sequences, dynamic programming, cray extreme multithreading supercomputer, parallelization, H1N1-H1N2 bottleneck viruses, minimum cost paths, molecular biology viewpoint, phylogenetics, Cray XMT, graph theory, influenza, multithreading, networks, pandemic, reassortment, shortest paths, S-OIV, swine flu., Animals, Computer Communication Networks, Evolution, Molecular, Genome, Viral, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Influenza, Human, Mutation, Pandemics, Reassortant Viruses, Sus scrofa, Swine
ISSN: 1545-5963 1557-9964 2374-0043
Sayı: 1
Cilt: 9
Sayfa: 214-227
Sınıflandırma :
Biyotıp %100
Viroloji %99
19
Detecting Differential Transcription Factor Binding Based on DNA Accessibility
Konferans Bildirileri

Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
John Lin , Thouis Ray Jones
Konu :
Bioengineering, Communication, Networking and Broadcast Technologies, Components, Circuits, Devices and Systems, Computing and Processing, General Topics for Engineers, Power, Energy and Industry Applications, Robotics and Control Systems
Yıl :
2020
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Common genetic diseases—systemic diseases that are caused by thousands of mutations—affect millions of people around the world. Many of these mutations fall within regulatory regions. While the mutations associated with these diseases are widely known from Genome Wide Association Studies (GWAS), the link between these mutations and their role in disease pathogenicity has largely gone undiscovered. This study harnesses single cell ATAC-seq data to differentiate sites where transcription factors (regulatory proteins) are bound or unbound, serving as a first step to understanding these diseases. In distinguishing between bound and unbound transcription factors, the study paves the way for using single cell ATAC-seq to understand the biochemical mechanism underlying common diseases by identifying the cell types and changes in transcription factor binding caused by genetic diseases.
DOI : 10.1109/urtc51696.2020.9668911
Anahtar Kelimeler : Proteins, Conferences, Genomics, DNA, Bioinformatics, Diseases, IEEE Regions, biochemistry, cellular biophysics, diseases, DNA, genetics, genomics, molecular biophysics, molecular configurations, proteins, disease pathogenicity, single cell ATAC-seq data, regulatory proteins, bound transcription factors, unbound transcription factors, differential transcription factor binding, DNA accessibility, genetic diseases, genome wide association studies, systemic diseases, mutations, biochemical mechanism, Transcription factor, single-cell sequencing, common genetic diseases, DNA accessibility
Sınıflandırma :
20
A Comparison of PAR-CLIP Peak Calling Approaches on Noisy Data
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Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
Oier Echaniz , Manuel Grana
Konu :
Bioengineering, Computing and Processing, Signal Processing and Analysis
Yıl :
2018
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Cross-Linking Immuno Precipitation associated to high-throughput sequencing (CLIP-seq) has been recently developed aiming to uncover the RNA-protein interaction genome-wide. CLIP-seq protocol has many steps involving sample preparation, sequencing and bioinformatics analysis. Specifically PhotoActivable-Ribonucleoside-enhanced-CLIP (PAR-CLIP) has been proposed increasing crosslinking efficiency, leading to a high number of thymidine to cytidine transitions in the cDNA at the crosslink sites, which can be exploited enabling PAR-CLIP to achieve single-nucleotide resolution. After read mapping into the reference genome, peak calling is the process of detecting the RNA-protein interaction with higher signal probability against the background of random iteraction and substitutions. PAR-CLIP specific peak calling methods propose probabilistic models based on its substitution properties, allowing for a more accurate detection of RNA-protein interaction sites. In this paper we review four peak calling approaches reporting a comparison carried out on a well known dataset.
DOI : 10.1109/bibm.2018.8621210
Anahtar Kelimeler : Sequential analysis, Bioinformatics, Genomics, RNA, Proteins, Protocols, Task analysis, bioinformatics, biological techniques, biology computing, DNA, genetics, genomics, molecular biophysics, probability, proteins, RNA, PAR-CLIP peak calling approaches, noisy data, Cross-Linking Immuno Precipitation, high-throughput sequencing, RNA-protein interaction genome-wide, CLIP-seq protocol, sample preparation, bioinformatics analysis, crosslinking efficiency, crosslink sites, reference genome, PAR-CLIP specific peak calling methods, RNA-protein interaction sites
Sınıflandırma :
Viroloji %19
21
Super Granular Shrink-SVM Feature Elimination (Super GS-SVM-FE) Model for Protein Sequence Motif Information Extraction
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Kaynak :
IEEE Xplore
Yazar(lar) :
Bernard Chen , Stephen Pellicer , Phang C. Tai , Robert Harrison , Yi Pan
Konu :
Bioengineering, Computing and Processing
Yıl :
2007
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Kaydet Alıntıla
Protein sequence motifs are gathering more and more attention in the sequence analysis area. These recurring regions have the potential to determine protein 's conformation, function and activities. In our previous work, we tried to obtain protein sequence motifs which are universally conserved across protein family boundaries. Therefore, unlike most popular motif discovering algorithms, our input dataset is extremely large. In order to deal with large input datasets, we provided two granular computing models (FIK and FGK model) to efficiently generate protein motifs information and Super GSVM-FE model to do the feature elimination for improving the quality of motif information. In this article, we tried to further improve our SVM feature elimination model to achieve three goals: Reduce time execution by half, further improve motif information quality and add the ability of adjusting the number of filtered segments. Compared with the latest results, our new approach shows great improvements.
DOI : 10.1109/bibe.2007.4375591
Anahtar Kelimeler : Protein sequence, Data mining, Sequences, Clustering algorithms, Space technology, Information filtering, Information filters, Biological system modeling, Computer science, Biology, biology computing, macromolecules, proteins, support vector machines, protein sequence motifs, information extraction, conformation, granular computing models, elimination model, filtered segments, fuzzy-Greedy-Kmeans model, super granular shrink-SVM feature elimination model
Sınıflandırma :
Viroloji %22
22
Smart Elevator Cabin Sanitization and Disinfection for COVID
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Kaynak :
IEEE Xplore
Yazar(lar) :
S. Nagaraj , K. Srividya , B. Puviyarasi , K. Santhosh , N. Sabareeswaran
Konu :
Communication, Networking and Broadcast Technologies, Computing and Processing, Fields, Waves and Electromagnetics, Photonics and Electrooptics, Power, Energy and Industry Applications, Robotics and Control Systems, Signal Processing and Analysis
Yıl :
2022
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Kaydet Alıntıla
Acute respiratory distress syndrome is a severe form of asthma. SARS-COV 2 is a virus that is the cause of the COVID epidemic. SARS- COV 2 is mostly transmitted through the air inhalation of respiratory droplets ejected by infected people. People are in danger as a result of this developing COVID-19 and other diseases like OMICRON with symptoms that are similar to COVID, by the patterns of transmission. The continuous pandemic demonstrates the need for us to work together to avoid disaster. Elevators are a type of transportation that are used even in small enclosed areas with a number of settings, frequently transporting a large number of users in a short period of time. For Infection prevention and control elevators should be redesigned. Currently, manual procedures are used for cleaning and disinfecting elevator cabins, which takes a lot of time and effort. User compliance is necessary for elevator hygiene standards such as hand sanitization and mask utilization. The proposed method presents a UV-C light-based technology for disinfecting elevator cabins automatically. This could be accomplished in a manner that does not intervene with the ordinary operation of elevator, which is controlled by a microcontroller.
DOI : 10.1109/ic3iot53935.2022.9768017
Anahtar Kelimeler : COVID-19, Pathogens, Pandemics, Microcontrollers, Transportation, Elevators, Coronaviruses, UV-C (ultraviolet rays-C band), Elevator, COVID
Etkinlik adı: 2022 International Conference on Communication, Computing and Internet of Things (IC3IoT)
Etkinlik yeri: Chennai, India
Etkinlik başlangıç tarihi: [2022,3,10]
Etkinlik bitiş tarihi: [2022,3,11]
Sınıflandırma :
Viroloji %85
23
EPGA-SC : A Framework for de novo Assembly of Single-Cell Sequencing Reads
Dergi Makalesi

Dergi Makalesi
Kaynak :
IEEE Xplore
Dergi:
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Yazar(lar) :
Xingyu Liao , Min Li , Junwei Luo , You Zou , Fang-Xiang Wu
Konu :
Bioengineering, Computing and Processing
Yıl :
2021
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Assembling genomes from single-cell sequencing data is essential for single-cell studies. However, single-cell assemblies are challenging due to (i) the highly non-uniform read coverage and (ii) the elevated levels of sequencing errors and chimeric reads. Although several assemblers for single-cell data have been proposed in recent years, most of them fail to construct correct long contigs. In this study, we present a new framework called EPGA-SC for de novo assembly of single-cell sequencing reads. The EPGA assembler has designed strategies to solve the problems caused by sequencing errors, sequencing biases, and repetitive regions. However, the extremely unbalanced and richer error types prevent EPGA to achieve high performance in single-cell sequencing data. In this study, we designed EPGA-SC based on EPGA. The main innovations of EPGA-SC are as follows: (i) classifying reads to reduce the proportion of false reads; (ii) using multiple sets of high precision paired-end reads generated from the high precision assemblies produced by other assembler such as SPAdes to overcome the impact of sequencing biases and repetitive regions; and (iii) developing novel algorithms for removing chimeric errors and extending contigs. We test EPGA-SC with seven datasets. The experimental results show that EPGA-SC can generate better assemblies than most current tools in most time in term of MAX contig, N50, NG50, NA50, and NGA50.
DOI : 10.1109/tcbb.2019.2945761
Anahtar Kelimeler : Sequential analysis, Genomics, Tools, Error correction, DNA, Technological innovation, Bioinformatics, bioinformatics, cellular biophysics, genetics, genomics, single-cell assemblies, nonuniform read coverage, sequencing errors, EPGA-SC, de novo assembly, single-cell sequencing reads, EPGA assembler, single-cell sequencing data, high precision assemblies, genomes, chimeric reads, sequencing biases, high precision paired-end reads, repetitive regions, MAX contig, N50, NG50, NA50, NGA50, Single-cell sequencing data, sequencing biases, repetitive regions, chimeric errors, assembly, Computational Biology, Repetitive Sequences, Nucleic Acid, Sequence Alignment, Sequence Analysis, DNA, Single-Cell Analysis
ISSN: 1545-5963 1557-9964 2374-0043
Sayı: 4
Cilt: 18
Sayfa: 1492-1503
Sınıflandırma :
Viroloji %61
24
Expression of EV71-VP1 Protein and Preparation of Its Polyclonal Antibody
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Kaynak :
IEEE Xplore
Yazar(lar) :
Yan Wu , Jingjing Gao , Sulan Yu , Shengjun Wang
Konu :
Bioengineering, Communication, Networking and Broadcast Technologies, Computing and Processing
Yıl :
2009
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Tam Metin
Kaydet Alıntıla
The objective of this study is to utilize the protein VP1 of Enterovirus 71 from clinical specimens of children with hand-foot-and-mouth disease (HFMD) to prepare the polyclonal antibody (pAb), prevented the viral infection. RNA got out from the diachorema of the sufferer was amplified by RT-PCR and nested PCR. The viral capsid protein (VP1) cDNA was inserted into the vector PET32a(+), an expression vector PET32a-VPl was constructed. The VP1 protein was expressed in E Coli. and induced by IPTG . The polyclonal antibody (pAb) against the fusion protein was prepared. ELISA and Western blot methods were used to identify the titer and specificity of the pAb. The VP1 protein and the polyclonal antibody were prepared successfully. The successful expression of the capsid protein VP1 of EV71 and the preparation of the polyclonal antibody can afford experiment foundation for the deep research of the biological function.
DOI : 10.1109/icbbe.2009.5162834
Anahtar Kelimeler : Immune system, Vaccines, Diseases, Rabbits, Pediatrics, RNA, DNA, Protein engineering, Biological materials, Resins, biochemistry, diseases, DNA, drugs, microorganisms, molecular biophysics, paediatrics, proteins, EV71-VP1 protein expression, polyclonal antibody preparation, hand-foot-and-mouth disease, viral infection prevention, RNA, diachorema, RT-PCR, viral capsid protein cDNA, PET32a-VPl expression vector, E Coli, fusion protein, ELISA method, Western blot method, enterovirus 71, nested PCR, PET32a(+) vector
Sınıflandırma :
Biyotıp %100
Viroloji %100
25
Unraveling the hCoV-19 Informational Architecture
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Kaynak :
IEEE Xplore
Yazar(lar) :
S. Aguilar-Valdez , J. Alejandro Morales , Omar Paredes
Konu :
Bioengineering
Yıl :
2021
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The hCoV-19 virus is continuously evolving to highly infectious and lethal variants. There is a latent risk that current vaccines will not be effective over these novel variants. This entails comprehending the genome-wide viral information to unveil mutagenic mechanisms of hCoV-19. To date, this virus is studied as a collection of non-related variants, making it challenging to forecast hotspots and their upcoming effects. In this work, we explore genome-wide information to disentangle informational mechanisms that lead to insights into viral mutagenicity. Towards this aim, we modeled informational compartments based on a topic-free-alignment workflow. These compartments illustrate that hCoV-19 has a complex informational architecture that addresses high-level virus phenomena, i.e., mutagenicity. This new framework represents the first step towards identifying the virus mutagenicity leading to the development of all-variants-effective vaccines.
DOI : 10.1109/embc46164.2021.9630954
Anahtar Kelimeler : COVID-19, Pandemics, Genomics, Focusing, Biology, Coronaviruses, Vaccines, bioinformatics, biology computing, diseases, DNA, genetics, genomics, microorganisms, molecular biophysics, proteins, complex informational architecture, high-level virus phenomena, virus mutagenicity, all-variants-effective vaccines, hCoV-19 informational architecture, hCoV-19 virus, highly infectious variants, lethal variants, latent risk, current vaccines, genome-wide viral information, mutagenic mechanisms, nonrelated variants, upcoming effects, genome-wide information, informational mechanisms, viral mutagenicity, informational compartments, topic-free-alignment workflow, SARS-CoV-2
Sınıflandırma :
26
Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions
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Kaynak :
IEEE Xplore
Yazar(lar) :
Ferdi Sarac , Volkan Uslan , Huseyin Seker , Ahmed Bouridane
Konu :
Bioengineering
Yıl :
2016
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
HIV-1 vaccine injection has been shown less effective due to the diversity of antigens. Increasing the knowledge of the associations between immune system and virus would ultimately result in producing effective vaccines against HIV-1 virus. To increase the understanding of immunological information, computational models can be utilised to construct predictive models. The aim of this study is, therefore, to predict the effect of antibody features (IgGs) and primary Natural Killing (NK) cells' cytotoxic activities on RV144 vaccine recipients and to disclose the functional relationship between immune system and HIV virus. The RV144 vaccine data set contains 100 data samples in which 20 of them are the placebo samples and 80 of them are the vaccine injected samples. Each data sample has twenty antibody features that consist of features related to IgG subclass and antigen specificity. In this paper, five different unsupervised feature selection methods (USFSMs) are utilised in order to identify the discriminating antibody features as USFSMs are regarded as unbiased approach. Then, the support vector based methods are utilised to assess association between cellular cytotoxicity by Natural Killer (NK) cells and cells that release glycoprotein (gp)120 antibody. The results yield high correlation coefficient as much as 0.48 and 0.65 for classificationthe support vector regression (SVR) and classification (SVM) predictive models, respectively.
DOI : 10.1109/embc.2016.7591378
Anahtar Kelimeler : Human immunodeficiency virus, Vaccines, Immune system, Support vector machines, Predictive models, Measurement, Computational modeling, cellular biophysics, feature selection, medical computing, microorganisms, patient treatment, proteins, regression analysis, support vector machines, toxicology, unsupervised feature selection methods, RV144 HIV vaccine-induced antibody features, natural killer cell-mediated cytotoxic reactions, HIV-1 vaccine injection, immune system, HIV-1 virus, antibody features, antigen specificity, USFSM, support vector machine, cellular cytotoxicity, glycoprotein, correlation coefficient, support vector regression, SVR, SVM classification, AIDS Vaccines, HIV Antibodies, HIV Envelope Protein gp120, HIV Infections, HIV-1, Humans, Killer Cells, Natural, Models, Immunological, Unsupervised Machine Learning
Sınıflandırma :
27
The Life and Perambulations of a Mouse by Dorothy Kilner
e-Kitap

e-Kitap
Open Access
Kaynak :
Project Gutenberg
Yazar(lar) :
Dorothy Kilner
Konu :
Mice , Juvenile fiction, Natural history , Juvenile fiction
Yıl :
1999
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Anahtar Kelimeler : ebook, ebooks, free ebooks, free books, book, books, audio books
Sınıflandırma :
28
Analysis of the inactivation mechanism of bacteriophage ϕX174 by atmospheric pressure discharge plasma
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Kaynak :
IEEE Xplore
Yazar(lar) :
Yoshimasa Tanaka , Hachiro Yasuda , Hirofumi Kurita , Kazunori Takashima , Akira Mizuno
Konu :
Robotics and Control Systems, Power, Energy and Industry Applications, Components, Circuits, Devices and Systems, Engineered Materials, Dielectrics and Plasmas, Communication, Networking and Broadcast Technologies, Computing and Processing
Yıl :
2012
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Kaydet Alıntıla
Inactivation technology of viruses by atmospheric pressure discharge plasma has been studied actively. However, the predominant factor in the inactivation is still unclear. Bacteriophages, consisting of only nucleic acids and coat proteins, are suitable for the study of the inactivation mechanism due to their simple structure. In this study, inactivation of bacteriophage φX174, which is resistant to drying stress and has some characteristics similar to influenza virus, was investigated using dielectric barrier discharge (DBD) or corona discharge. We exposed wet or dry bacteriophage φX174 to discharge plasma. It is possible to extract the nucleic acids from the bacteriophage and to assay its plaque forming activity by transfection. Therefore, the damage given to the DNA can be separately analyzed. The coat proteins were also analyzed. Both DNA and coat proteins of plasma-treated φX174 phage were damaged, however, the damages of coat proteins were more significant compared to the DNA damages.
DOI : 10.1109/ias.2012.6373981
Anahtar Kelimeler : Decision support systems, Atmospheric-pressure plasmas, biological effects of ionising radiation, biomedical engineering, biomolecular effects of radiation, corona, DNA, electric breakdown, microorganisms, plasma applications, proteins, bacteriophage phi-X174 inactivation mechanism, atmospheric pressure discharge plasma, virus inactivation technology, bacteriophage nucleic acids, bacteriophage coat proteins, dielectric barrier discharge, DBD, corona discharge, plaque forming activity, transfection, DNA damage, bacteriophage ⊘X174, atmospheric pressure discharge plasma, transfection
Sınıflandırma :
Viroloji %95

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