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COVID-19 Vaccines : A literature analysis of the three first approved COVID-19 Vaccines in the EU
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Morgan Persson
Yıl :
2021
COVID-19 Vaccines : A literature analysis of the three first approved COVID-19 Vaccines in the EU
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Kaydet
Anahtar Kelimeler : Basic Medicine
Sınıflandırma :
2
Resolution of coronavirus disease 2019 (COVID-19)
Tez

Tez
Kaynak 1:
NDTLD Thesis
Kaynak 2:
NDTLD Thesis
Yazar(lar) :
Khaled S.A. Habas
Yıl :
2020
Resolution of coronavirus disease 2019 (COVID-19) Coronavirus disease 2019 ( COVID- 19) was first detected in China in December, 2019, and declared as a pandemic by the World Health Organization (WHO) on The current management of COVID- 19 is based generally on supportive therapy and treatment to prevent respiratory failure. - 19. COVID-19
Kaydet
Yes / Introduction. Coronavirus disease 2019 (COVID-19) was first detected in China in December, 2019, and declared as a pandemic by the World Health Organization (WHO) on March 11, 2020. The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure. The effective option of antiviral therapy and vaccination are currently under evaluation and development. Areas covered. A literature search was performed using PubMed between December 1, 2019–June 23, 2020. This review highlights the current state of knowledge on the viral replication and pathogenicity, diagnostic and therapeutic strategies, and management of COVID-19. This review will be of interest to scientists and clinicians and make a significant contribution toward development of vaccines and targeted therapies to contain the pandemic. Expert Opinion. The exit strategy for a path back to normal life is required, which should involve a multi-prong effort toward development of new treatment and a successful vaccine to protect public health worldwide and prevent future COVID-19 outbreaks. Therefore, the bench to bedside translational research as well as reverse translational works focusing bedside to bench is very important and would provide the foundation for the development of targeted drugs and vaccines for COVID-19 infections. / Research carried out at TN laboratories are funded by the GrowMedtech, The Royal Society and University of Bradford. KH is supported by a project grant by the GrowMedtech awarded to TN. CW is funded by a Ph.D studentship.
Anahtar Kelimeler : Novel coronavirus, SARS-CoV-2, COVID-19, Diagnosis, Epidemiology, Pathology, Treatment
Sınıflandırma :
3
COVID-19-associated encephalopathy: Neurological manifestation of COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Radiology Case Reports
Yazar(lar) :
Safaa Saeed Al Mazrouei , MBBS , Ghufran Aref Saeed , MBBS , Abeer Ahmed Al Helali , MBBS , Manzoor Ahmed , MBBS
Yıl :
2020
COVID-19-associated encephalopathy: Neurological manifestation of COVID-19 Coronavirus disease 2019 ( COVID- 19) is a viral disease, also known as severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China COVID- 19-associated neurological manifestations have not been widely reported. In this report, we describe a case of encephalopathy in a patient with COVID- 19 infection. Covid-19
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Coronavirus disease 2019 (COVID-19) is a viral disease, also known as severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China, December 2019. Respiratory manifestations from the induced acute lung injury were the most common reported findings. Few cases showed extrapulmonary manifestations. COVID-19-associated neurological manifestations have not been widely reported. In this report, we describe a case of encephalopathy in a patient with COVID-19 infection.
Anahtar Kelimeler : Covid-19, coronavirus, RT-PCR, reverse transcription polymerase chain reaction, central nervous system, Encephalopathy
ISSN: 1930-0433
Cilt: 15
Sayı: 9
Sayfa: 1646 - 1649
Sınıflandırma :
4
COVID-19
Sunum

Sunum
Open Access
Kaynak 1:
Akademik Sunum
Kaynak 2:
Science Direct
Yazar(lar) :
Mustafa TAYAR
Yıl :
2020
COVID-19 CORONAVIRUS ( COVID- 19) ile mücadele programı Prof.Dr.Mustafa TAYAR İşyerinizi COVID-19a hazır hale getirme SIMULATION EXERCISE NOVEL CORONAVIRUS ( COVID Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS ( COVID- 19) page 4 Coronavirüsten korunma yolları Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS ( COVID- 19) page 5 Okullar için önemli hijyen noktaları Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS ( COVID- 19) page COVID-19
Kaydet
CORONAVIRUS (COVID-19) ile mücadele programı Prof.Dr.Mustafa TAYAR İşyerinizi COVID-19a hazır hale getirme SIMULATION EXERCISE NOVEL CORONAVIRUS (COVID-19) page 2 Çalışma alanınız,virüslere ve salgınlara karşı hazırlıklı mı? Tuesday, October 27, 2020 Öğrenciler, çalışanlar ve misafirleriniz coronavirüs ile karşı karşıya kalma durumlarında güvenli bir çalışma ortamının sağlanmasına ihtiyaç duyarlar SIMULATION EXERCISE NOVEL CORONAVIRUS (COVID-19) page 3 Coronavirüs nedir? Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS (COVID-19) page 4 Coronavirüsten korunma yolları Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS (COVID-19) page 5 Okullar için önemli hijyen noktaları Tuesday, October 27, 2020 SIMULATION EXERCISE NOVEL CORONAVIRUS (COVID-19) page 6 Yemekhane
Anahtar Kelimeler : COVID-19
Sunum Formatı : pptx
Sunum Sayfa Sayısı : 27
Sınıflandırma :
Biyotıp %100
5
Investigating the autoimmunity profiles of Covid-19 patients
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Alfred Kedhammar
Yıl :
2021
Investigating the autoimmunity profiles of Covid-19 patients The clinical severity of Covid- 19 varies greatly between individuals, and all underlying risk factors are not yet well understood. In this project, the interplay between severe Covid- 19 and autoimmunity was investigated in 114 Swedish patients, sampled in April- May 2020 as well as - 19 varierar kraftigt mellan individer och alla underliggande riskfaktorer är ännu inte förstådda. Covid-19 Covid-19
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The clinical severity of Covid-19 varies greatly between individuals, and all underlying risk factors are not yet well understood. Previous studies have shown Covid patients to be enriched with autoantibodies against type I interferons, suggesting autoimmunity may be an underlying factor of susceptibility to severe disease. In this project, the interplay between severe Covid-19 and autoimmunity was investigated in 114 Swedish patients, sampled in April- May 2020 as well as longitudinal re-samplings 4 and 8 months later, using the infrastructure of the Human Protein Atlas and the SciLife lab autoimmunity and serology profiling unit. First, 16 patients with few comorbidities were analyzed for autoantibodies at a near proteome-wide scale using planar microarrays, after which a custom antigen panel was assembled based on observed reactivities and literature studies. The antigen panel was implemented in a 384-plex suspension bead array which was run for all patient samples and a control group. Among the Covid patients, 23 antigens were called as differentially reactive and 8 of them were proposed as relevant to immunoregulation or Covid pathogenesis. The results partially replicated previous findings of autoimmunity directed to type I interferons and offer a list of candidate autoantigens for further inquiries. / Allvarlighetsgraden av sjukdomen Covid-19 varierar kraftigt mellan individer och alla underliggande riskfaktorer är ännu inte förstådda. Tidigare studier har påvisat Covidpatienter som överrepresenterade med autoantikroppar mot typ I interferoner, vilket förespråkar autoimmunitet som en möjlig underliggande riskfaktor till att utveckla allvarlig Covid. I detta projekt användes infrastrukturen av det mänskliga proteinatlasprojektet och enheten för autoimmunitets- och serologiprofilering på SciLife lab för att undersöka samspelet mellan allvarlig Covid-19 och autoimmunitet i 114 st svenska patienter inlagda under april-maj 2020, samt från uppföljningsprover 4 resp. 8 månader senare. Till en början undersöktes 16 patienter med låg grad av samsjukdom för förekomst av autoan- tikroppar mot proteomet i stort med hjälp av mikroarrayer. En panel av antigen sammanställdes därefter baserat på resultaten och litteraturstudier. Panelen implementerades som en 384-plex kulsuspensionsarray vilken kördes för alla patientprover samt en kontrollgrupp. Ibland Covidpatienterna klassades 23 st antigen som överrepresenterade, varav 8 st avsågs relevanta för immunoreglering eller sjukdomsförlopp. Resultaten visades delvis återskapa tidigare fynd av autoimmunitet riktad mot typ I interferoner och erbjuda en lista av potentiella autoantigen för vidare efterforskningar.
Anahtar Kelimeler : Covid-19, SARS-CoV-2, Autoimmunity, Autoantibodies, Cytokines, Covid-19, SARS-CoV-2, Autoimmunitet, Autoantikroppar, Cytokiner
Sınıflandırma :
Viroloji %67
6
Why COVID-19?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Advanced Journal of Emergency Medicine
Yazar(lar) :
Elnaz Vahidi , Mohammad Jalili
Yıl :
2020
Why COVID-19? Covid- 19 has been estimated to have a case fatality rate of around 3%. In late December 2019, an outbreak of COVID- 19 was reported from Wuhan city, China. Today COVID- 19 has affected more than 212 countries and has made billions of people to be quarantined in their houses.
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COVID-19 is a highly contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), an enveloped positive stranded RNA virus and the third member of the family Coronaviridae which has emerged as a zoonotic infection. The predecessor of this new pathogen caused the Severe Acute Respiratory Syndrome (SARS) in 2003 and the Middle East Respiratory Syndrome (MERS) in 2012. Although corona viruses have been known since 1960’s, their familiar species were human pathogens and caused common cold and seasonal flu. SARS-CoV-2 is easily transmitted via respiratory secretions of an infected person, with a reproductive number (the average number of cases to which a single infected person will transmit the virus) of 1.4-2.5. Covid-19 has been estimated to have a case fatality rate of around 3%. As of today, asymptomatic transmission is assumed to be possible during the incubation period, which usually ranges from 2-14 days. The source of infection, animal host, and reservoir are currently unknown. In late December 2019, an outbreak of COVID-19 was reported from Wuhan city, China. The disease soon spread outside China borders and became rapidly prevalent all around the world. The pandemic announcement was officially made by World Health Organization (WHO) on 11 March 2020. Today COVID-19 has affected more than 212 countries and has made billions of people to be quarantined in their houses. Up to now, almost 1500000 confirmed cases of COVID-19 have been reported globally and the death toll has been declared to be 86000. In Iran, we are also facing this unprecedented global public health emergency, with about 65000 confirmed cases and 3993 deaths. This pandemic is beyond an expanding contagious disease and has influenced different features of life. Its enormous social, political, and specifically economic impacts all around the world are undeniable. In low- and middle-income countries this can potentially lead to a huge spike in poverty and collapse. Many vulnerable families have lost their income and access to the essential needs. Education systems have collapsed in many regions. The long-term effect of this global crisis has reduced economic growth even in developed countries. Economic effects of COVID-19 are estimated with dramatic variations. Orlik et al in Bloomberg hypothesized this cost to be $2.7 trillion. The political consequences are even harder to predict but quite significant and devastating, like the heated discussion, criticism and accusation flowing between the leaders of different countries. Since the pandemic is not yet over, the global influence will carry on to happen and make situation even more complicated. While the outbreak is evolving rapidly, health care systems across the world are actively fighting against the new virus. They have encountered many new challenges. Public health measures (such as active case finding, prompt isolation of cases and contacts tracing) to contain the spread of the disease in the society as well as provision of care for the unpredictably high number of people who are infected with the virus have stretched the healthcare system beyond its capacity. At the same time, protecting health care providers’ safety, which often requires provision of sufficient supplies of personal protective equipment, has definitely challenged the system. Societal demand for discovery of a definitive treatment and vaccine has also added to the complexity of the situation that the health care systems are facing. Studies about COVID-19 are increasingly being performed and published; many of them have not yet been fully reviewed and criticized by the academic community. Practitioners often find it difficult to find, appraise and apply the information they need amid the turbulence of their clinical practice. Furthermore, there are still many questions to be answered. The most efficient method for personal protection, methods of viral transmission, most accurate diagnostic approaches, and effective treatment options are yet to be determined. This special issue of the Advanced Journal of Emergency Medicine plans to specifically focus on COVID-19 by gathering the relevant scientific information available. We hope that by publishing high quality papers, this journal can provide its readers with further required information. Appropriate management of patients suffering COVID-19 as well as controlling this pandemic are our ultimate aspirations. We encourage further researches in this field by all scientists and physicians all across the world to be able to eradicate COVID-19 as soon as possible.
DOI : 10.22114/ajem.v0i0.402
ISSN: 2588-400X
Sınıflandırma :
Viroloji %77
7
Fighting COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Brazilian Journal of Biology
Yazar(lar) :
D. M. O. Campos , C. B. S. Oliveira , J. M. A. Andrade , J. I. N. Oliveira
Fighting COVID-19 Abstract The current COVID- 19 pandemic caused by the novel coronavirus (SARS-CoV2) poses a threat to global health owing to its high rate of spread and covid-19
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Abstract The current COVID-19 pandemic caused by the novel coronavirus (SARS-CoV2) poses a threat to global health owing to its high rate of spread and severe forms of respiratory infection. The lack of vaccines and antivirals prevents clinical strategies against the disease, creating an emerging need for the development of safe and effective treatments. Strategies for vaccine development include complete vaccines against viruses, subunits, and nucleic acids, but are still in their early stages. Studies carried out to date on possible SARS-CoV2 drug targets highlight glycoprotein S, Mpro (main protease or protease type 3C), and a member of the transmembrane serine protease II families (TMPRSS2). However, due to the pandemic state, priority is given to marketed drugs. These include chloroquine (CQ), hydroxychloroquine (HCQ), nitazoxanide, remdesivir, Lopinavir/ritonavir (LPV / r), in addition to treatment with convalescent plasma. But, therapeutic specific effects against SARS-CoV2 have not yet been verified. Most of the information obtained about treatment is based on preliminary and limited studies. We conclude that, at this time of emergency, the search for new therapies is more urgent due to the need to save lives. Thus, we point out as interesting targets for future more specific research: glycoprotein S, Mpro, and TMPRSS2.
DOI : 10.1590/1519-6984.238155
Anahtar Kelimeler : virology, sars-cov2, covid-19, infectious diseases
Sınıflandırma :
Biyotıp %100
Viroloji %99
8
COVID-19 solution
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Preventive Medicine
Yazar(lar) :
Roberto Menicagli , Mario Limodio
Yıl :
2020
COVID-19 solution Some CoVs have recently entered humans from infected animals and lastly we have SARS COVID- 19, (CoV), which causes severe acute, often fatal respiratory sars covid-19
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Kaydet
Coronaviruses (CoV) are RNA viruses that cause endemic infections in various species of mammals and avian birds. There are seven known human CoVs, each of which causes respiratory diseases: together account for about one third of common colds. Some CoVs have recently entered humans from infected animals and lastly we have SARS COVID-19, (CoV), which causes severe acute, often fatal respiratory syndromes. The prevalence of CoV, the easy zoonotic transmission and the potential to cause serious respiratory diseases, lead to urgent research to discover the mechanisms of CoV infection. Our study has identified a possible way to eliminate the danger of this virus by analyzing the structures by which it enters the host cell. This study indicates that the neuroaminidase interrupts the infection.
DOI : 10.4103/ijpvm.IJPVM_227_20
Anahtar Kelimeler : neuroaminidase, sars covid-19, sialic acid
Cilt: 11
Sayı: 1
Sayfa: 73 - 73
Sınıflandırma :
Viroloji %95
9
COVID-19: Immunopathogenesis
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
Yazar(lar) :
Deniz MAVİ , Ahmet Çağkan İNKAYA
Yıl :
2020
COVID-19: Immunopathogenesis Coronavirus- 19 disease ( COVID- 19) first described in Wuhan, China at the end of 2019. respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID - 19.
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Tam Metin
Kaydet
Coronavirus-19 disease (COVID-19) first described in Wuhan, China at the end of 2019. It spread rapidly all over the world and claimed the lives of over 300,000 people. There is no known effective vaccine and treatment yet. It is impossible to develop vaccines and specific treatment without understanding the pathogenesis of the disease. Experience from severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID-19. Nevertheless, many issues remained obscure regarding the pathogenesis of SARS-CoV-2. Exaggerated immune response leads to respiratory failure and even complications which may culminate in death. Cytokines storm, the complement system, endothelial damage, coagulation cascade, cellular and humoral immunity all play an important role in immune pathogenesis and inflammation. In this review, the relationship between the immune response/host characteristics of SARS-CoV-2 and the severity of the disease, antibody responses, and immune pathogenesis, possible causes of hypercoagulation will be discussed and it’s aimed to provide perspective on the development of effective vaccines and specific treatment.
DOI : 10.5578/flora.69606
Anahtar Kelimeler : sars-cov, sars-cov-2, immunopathogenesis, cytokine storm
ISSN: 1300-932X
Cilt: 25
Sayı: 2
Sayfa: 121 - 131
Sınıflandırma :
Viroloji %74
10
Asymptomatic COVID-19 Infection Management: The Key to Stop COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Clinical and Experimental Investigations
Yazar(lar) :
Rachid Ait Addi , Abdelhafid Benksim , Mohamed Amine , Mohamed Cherkaoui
Yıl :
2020
Asymptomatic COVID-19 Infection Management: The Key to Stop COVID-19 The COVID- 19 disease, emerged in December 2019, has spread rapidly, with new cases confirmed in multiple countries. portion of the population to virus and increase the late diagnosis and thereafter enhance COVID- 19 mortality. Thereafter, it is fundamental to review our COVID- 19 screening approach and enlarge COVID- 19 testing to the general population by using rapid testing appliances COVID-19
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Kaydet
The COVID-19 disease, emerged in December 2019, has spread rapidly, with new cases confirmed in multiple countries. Many efforts to contain the virus are ongoing, such as containment, individual measures of protection, the authorization of use of some drugs as chloquorine in some countries. Also, it has been known that symptomatic and asymptomatic people whom are infected by COVID-19 have the same contagiousness which expose a far greater portion of the population to virus and increase the late diagnosis and thereafter enhance COVID-19 mortality. Thereafter, it is fundamental to review our COVID-19 screening approach and enlarge COVID-19 testing to the general population by using rapid testing appliances such as rapid SARS-CoV-2 IgG-IgM combined antibody since another appliance more efficient will be performed.
DOI : 10.5799/jcei/7866
Anahtar Kelimeler : COVID-19, pandemic, screening, diagnosis
Cilt: 11
Sayı: 3
Sayfa:
Sınıflandırma :
11
Coronavirus (COVID-19):
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Dergi Makalesi
Open Access
Kaynak :
Springer Link
Dergi:
TBV – Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde
Yayıncı:
Springer Link
Yazar(lar) :
Julitta Boschman , Jan Hoving , Jos Verbeek
Konu :
ccupational Medicine
Yıl :
2020
Coronavirus (COVID-19):
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DOI : 10.1007/s12498-020-0733-z
ISSN: 1876-5858
Cilt: 28
Sayı: 4
Sayfa: 6-7
Sınıflandırma :
12
Expression of ACE2 protein and COvid-19 severityThe role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 severity: a comprehensive review
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Rui Seabra Rodrigues
Yıl :
2021
Expression of ACE2 protein and COvid-19 severityThe role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 severity: a comprehensive review - 19. - 19. 2 (SARS-CoV-2), the virus responsible for the COVID- 19 pandemic.
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Kaydet
A Enzima de Conversão da Angiotensina (ECA2) é uma proteína expressa ao nível da membrana celular, amplamente expressa em tecidos humanos, como o cardíaco e o pulmonar, e já foi provada ser o principal recetor do vírus SARS-CoV-2, responsável pela pandemia COVID-19. A proteína Spike (S) do SARS-CoV-2 liga-se à ECA2 para iniciar o processo de infeção e replicação nas células hospedeiras. A patofisiologia desta proteína na infeção por SARS-CoV-2 é complexa e pode estar associada a diversas condições que cursam com maior severidade da COVID-19, condições estas como a idade, género masculino e comorbilidades associadas aos doentes, nomeadamente, doenças cardiovasculares, doenças respiratórias crónicas, obesidade e diabetes. Neste artigo, apresentamos uma revisão global que visa correlacionar os níveis de expressão da ECA2 em vários órgãos com um pior prognóstico, em pacientes com COVID-19. Neste sentido, níveis significativamente mais elevados de expressão de ECA2 foram observados nos tecidos cardíaco e pulmonar de pacientes com Insuficiência Cardíaca e DPOC, respetivamente. Além disso, um aumento progressivo da expressão da proteína no epitélio respiratório, com a idade, também pode justificar um aumento da severidade da infeção nos idosos. Por último, não parece existir uma associação entre inibidores do sistema renina-angiotensina-aldosterona (RAAS) e uma maior gravidade da infeção por COVID-19. / Angiotensin-Converting Enzyme 2 (ACE2) has been proved to be the main host cell receptor for binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the COVID-19 pandemic. SARS-CoV-2 Spike (S) protein binds to ACE2 to initiate the process of replication. This enzyme is widely present in human organ tissues, like heart and lung. The pathophysiology of ACE2 in SARS-CoV-2 infection is complex and may be associated with several conditions that are more severe in COVID-19 patients, such as age, male gender, and comorbidities, namely cardiovascular diseases, chronic respiratory diseases, obesity, and diabetes. Here we present a comprehensive review aimed to correlate the levels of expression of the ACE2 in various organs, with a poor outcome in COVID-19 patients. Significantly higher levels of expression of ACE2 were observed in myocardial and lung tissues in heart failure and COPD patients, respectively. An age-dependent increase in SARS2-CoV-2 receptors in the respiratory epithelium may be also responsible for the increased severity of COVID-19 lung disease in elderly people. Although the role of ACE2 is highlighted regarding the damage that can arise upon the SARS-CoV-2 invasion, there was no association observed between renin-angiotensin-aldosterone system (RAAS) inhibitors and the severity of COVID-19.
Anahtar Kelimeler : Ciências da saúde, Health sciences
Sınıflandırma :
Biyotıp %100
Viroloji %100
13
Vitamin D and Covid-19
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
academie-medecine.fr
Yayıncı:
academie-medecine.fr
Yazar(lar) :
French National Academy of Medicine
Yıl :
2020
Vitamin D and Covid-19 Vitamin D and Covid- 19 Press release from the French National Academy of Medicine 22 May 2020 Vitamin D is a prohormone synthesized in the dermis under - 19. This would explain why infants, who receive vitamin D regularly, have asymptomatic forms of Covid- 19 and fewer complications.
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Vitamin D and Covid-19 Press release from the French National Academy of Medicine 22 May 2020 Vitamin D is a prohormone synthesized in the dermis under the effect of ultraviolet light, i.e. sunrays, and then transported to the liver and kidney, where it is transformed into an active hormone. It is responsible for intestinal absorption of calcium and bone health. But vitamin D also has unconventional effects. In particular, it modulates the functioning of the immune system by stimulating macrophages and dendritic cells [1,2,3], It plays a role in regulating and suppressing the cytokine inflammatory response that causes the acute respiratory distress syndrome that characterizes the severe and often lethal forms of Covid-19. A significant correlation between low serum vitamin D levels and mortality from the Covid- 19 has been shown [4], This phenomenon generally follows a North-South gradient, although there are exceptions such as the Nordic countries, where vitamin D nutrient supplementation, particularly from milk products, is systematic. However, Southern European countries show a surprisingly high prevalence of vitamin D deficiency, despite higher levels of sunlight [5]. This would explain why infants, who receive vitamin D regularly, have asymptomatic forms of Covid-19 and fewer complications. Vitamin D cannot be considered as a preventive or a curative treatment for CoV-2 SARS infection. However, by mitigating the inflammatory storm and its consequences, it could be considered as an adjunct to any form of therapy. The National Academy of Medicine
14
COVID 19: Neuromuscular manifestations
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Annals of Indian Academy of Neurology
Yazar(lar) :
Rajesh Benny , Satish V Khadilkar
Yıl :
2020
COVID 19: Neuromuscular manifestations COVID- 19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. This manuscript studies the available information on the neuromuscular manifestations of COVID- 19. covid-19 neurological manifestations covid-19 neuromuscular manifestations
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COVID-19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. Neuromuscular manifestations have been reported uncommonly in these early stages of the analysis. This manuscript studies the available information on the neuromuscular manifestations of COVID-19.
DOI : 10.4103/aian.AIAN_309_20
Anahtar Kelimeler : covid-19 neurological manifestations, covid-19 neuromuscular manifestations, guillain barre syndrome, myositis
Cilt: 23
Sayı: 7
Sayfa: 40 - 42
Sınıflandırma :
Viroloji %27
15
Can Myrrh Combat COVID-19?
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
Internet Archive
Yayıncı:
Internet Archive
Yazar(lar) :
Iberoamerican Journal of Medicine
Yıl :
2020
Can Myrrh Combat COVID-19? It noticed in the State of Qatar, sales of herbs and Myrrh has escalade since the surgency of COVID- 19 cases, so is there a belief in Myrrh's effectiveness to be used during COVID- 19? Studying the effectiveness of Myrrh mouthwashes to combat COVID- 19 can emerge as a promising avenue in the field of research.
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This paper reviews the therapeutic effects of Commiphora myrrh in different diseases. It is organized by sub-themed sections: nature and history of myrrh, its use in different cultures, its chemical action, and effect on virus or/and bacteria, benefits of its utilization for respiratory problems and oral diseases. A literature research for the Myrrh or C. myrrh was performed using Cochrane Library databases and Medline. Forty two papers, including abstracts and full articles published from 2007 to 2020, in the area of interest were reviewed. It was found that Myrrh or C. myrrh is one of the medicinal plants believed to have therapeutic effects in various diseases. It has medicinal properties, such as immunomodulatory, anti-inflammatory, cytotoxic, antioxidant, antimicrobial, hepatoprotective, anti-tumor, anti-ulcer, and analgesic activities. Besides, Myrrh has also shown to have antiviral properties that help in preventing different types of viral diseases. It noticed in the State of Qatar, sales of herbs and Myrrh has escalade since the surgency of COVID-19 cases, so is there a belief in Myrrh's effectiveness to be used during COVID-19? Studying the effectiveness of Myrrh mouthwashes to combat COVID-19 can emerge as a promising avenue in the field of research.
Sınıflandırma :
16
Tobacco and COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Eurasian Journal of Pulmonology
Yazar(lar) :
Ozlem Sonmez , Zeynep Atam Taşdemir , H Volkan Kara , Sule Akçay
Yıl :
2020
Tobacco and COVID-19 Similar data have been approved found for coronavirus disease-2019 ( COVID- 19) pandemic. adverse effects of tobacco and tobacco products and to raise awareness among the public and to make efforts to smoking on every opportunity during the COVID - 19 pandemic. covid-19
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Tobacco and its products are the well-known causes of premature deaths associated with cancer, cardiovascular disease, and chronic obstructive pulmonary disease, as well as they constitute a significant risk factor that increases the tendency to respiratory system infection and other systemic infections. Active tobacco use and passive smoking increase the risk of infection. Both increase peribronchial and alveolar inflammation and fibrosis and mucosal permeability, cause inadequate mucociliary cleaning, damage to the respiratory tract epithelium resulting in fibrosis, and they adversely affect cellular and humoral immunity. Smoking has been known to increase the risk for viral infections and influenza. Similar data have been approved found for coronavirus disease-2019 (COVID-19) pandemic. Smoking is reported to be associated with the frequency of the disease and its severity of the clinical course. Severe acute respiratory syndrome-coronavirus-2 penetrates the cell using the angiotensin-converting enzyme 2 receptors. Such receptor proteins had been shown to increase in smoker individuals. Also, smoking facilitates penetration of the virus into the cell. The frequency of smoking and the rates of admission to intensive care, mechanical ventilation, and mortality have been also found to be higher was higher in severe cases. The risk for disease progression was found to be 14-fold higher in smokers. Further, the World Health Organization emphasized similar negative effects of hookah and new tobacco products such as electronic cigarettes and heated tobacco products. It is vital to underline the adverse effects of tobacco and tobacco products and to raise awareness among the public and to make efforts to smoking on every opportunity during the COVID-19 pandemic. Public awareness campaigns during the pandemic must always accompanied by the methods and strategies to avoid active and passive smoking.
DOI : 10.4103/ejop.ejop_52_20
Anahtar Kelimeler : covid-19, sars-cov-2, smoking, tobacco use
Cilt: 22
Sayı: 4
Sayfa: 12 - 15
Sınıflandırma :
17
COVID-19: a review
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Monaldi Archives for Chest Disease
Yazar(lar) :
Irappa Madabhavi , Malay Sarkar , Nagaveni Kadakol
Yıl :
2020
COVID-19: a review The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus ( COVID- 19) or the severe acute A highly virulent and pathogenic COVID- 19 viral infection with incubation period ranging from two to fourteen days, transmitted by breathing of infected Approximately 1,016,128 reported cases, 211,615 recovered cases and 53,069 deaths of COVID-2019 have been reported to date (April 2, 2020). COVID-19
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The enduring epidemic outbreak which started in Wuhan city of China, in December 2019 caused by the 2019 novel coronavirus (COVID- 19) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a dangerous and deadly Public Health disaster of International apprehension, with cases confirmed in several countries. This novel community health trouble is frightening the universe with clinical, psychological, emotional, collapse of health system and economical slowdown in each and every part of the world infecting nearly 200 countries. A highly virulent and pathogenic COVID-19 viral infection with incubation period ranging from two to fourteen days, transmitted by breathing of infected droplets or contact with infected droplets, belongs to the genus Coronavirus with its high mutation rate in the Coronaviridae. The likely probable primary reservoir could be bats, because genomic analysis discovered that SARSCoV-2 is phylogenetically interrelated to SARS-like bat viruses. The transitional resource of origin and transfer to humans is not known, however, the rapidly developing pandemic has confirmed human to human transfer. Approximately 1,016,128 reported cases, 211,615 recovered cases and 53,069 deaths of COVID-2019 have been reported to date (April 2, 2020). The symptoms vary from asymptomatic, low grade pyrexia, dry cough, sore throat, breathlessness, tiredness, body aches, fatigue, myalgia, nausea, vomiting, diarrhea, to severe consolidation and pneumonia, acute respiratory distress syndrome (ARDS) and multiple organ dysfunction leading to death with case fatality rate ranging from 2 to 3%.
DOI : 10.4081/monaldi.2020.1298
Anahtar Kelimeler : Coronavirus, COVID-19, outbreak, infection, pneumonia
Cilt: 90
Sayı: 2
Sınıflandırma :
18
COVID-19 and hypertension
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of the Renin-Angiotensin-Aldosterone System
Yazar(lar) :
Spoorthy Kulkarni , Bernadette L. Jenner , Ian Wilkinson
Yıl :
2020
COVID-19 and hypertension
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DOI : 10.1177/1470320320927851
Cilt: 21
Sınıflandırma :
19
Cannabinoids and COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Medical Cannabis and Cannabinoids
Yazar(lar) :
Myriam El Biali , Barbara Broers , Marie Besson , Jules Demeules
Yıl :
2020
Cannabinoids and COVID-19 involved in immune function, the effect of cannabinoid intake on infectious conditions is questioned for several years and is of particular interest in the COVID 19 pandemia. covid-19
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Since the endocannabinoid system is involved in immune function, the effect of cannabinoid intake on infectious conditions is questioned for several years and is of particular interest in the COVID 19 pandemia. Some data suggest that the immunomodulatory effect of cannabinoids may affect the course and severity of SARS-CoV-2 infection. Given the large number of cannabinoids consumers in the community, this commentary presents the current knowledge on the potential impact of cannabinoids and endocannabinoids on bacterial and viral infection courses namely SARS-CoV-2 disease. Practical recommendations, which can be drawn from the literature, are given.
DOI : 10.1159/000510799
Anahtar Kelimeler : sars-cov-2, covid-19, immunity, cannabinoids, endocannabinoid system
ISSN: 2504-3889
Sayfa: 1 - 5
Sınıflandırma :
20
COVID-19: Apocalypse Now?
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Cellular and Molecular Anesthesia
Yazar(lar) :
Ali Dabbagh
Yıl :
2020
COVID-19: Apocalypse Now?
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DOI : 10.22037/jcma.v5i1.29845
Cilt: 5
Sayı: 1
Sayfa: 1 - 2
Sınıflandırma :
21
Pathogenesis of COVID-19
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Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Eurasian Journal of Pulmonology
Yazar(lar) :
Evrim Eylem Akpinar
Yıl :
2020
Pathogenesis of COVID-19 The coronavirus disease 2019 ( COVID- 19) is a very contagious infectious disease which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV The aim of this report is to review the immunopathogenesis of COVID- 19 in the light of current literature. covid-19
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The coronavirus disease 2019 (COVID-19) is a very contagious infectious disease which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is first identified in Wuhan city of China in December 2019 and in a short time dispersed to rest of the World. Animal to human transmission of the virus happened by eating of an infected animal and then the virus is transmitted to healthy persons by close contact. Coronaviruses attach and enter to the host cells by means of the spikes on the cell membrane. The type 2 pneumocytes are the primary target of the virus. The aim of this report is to review the immunopathogenesis of COVID-19 in the light of current literature.
DOI : 10.4103/ejop.ejop_54_20
Anahtar Kelimeler : coronavirus, covid-19, pathogenesis
Cilt: 22
Sayı: 4
Sayfa: 8 - 11
Sınıflandırma :
Viroloji %88
22
Stand on the Same Side Against Covid – 19 Clinical Management of Covid-19
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Substantia
Yazar(lar) :
Lorenzo Corbetta , Leonardo M. Fabbri , Shiyue Li , Jing Li , Bin Cao , Jin Yang , Giancarlo Agnelli , Michela Giustozzi , Alberto Mantovani , Luigi Camporota , Semra Bilaçeroğlu , Adrian Rendon
Yıl :
2020
Stand on the Same Side Against Covid – 19 Clinical Management of Covid-19 Covid-19
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This document is the direct transcription of a Webinar organized by Prof. L. Corbetta of the University of Florence on May 29th, 2020.
DOI : 10.13128/Substantia-1022
Anahtar Kelimeler : Covid-19, Clinical Management, LOTUS China Trial, Lopinavir, Ritonavir, Wuhan
ISSN: 2532-3997
Cilt: 4
Sayı: 1
Sınıflandırma :
23
Covid-19 and Neurology
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Türk Nöroloji Dergisi
Yazar(lar) :
Şerefnur Öztürk
Yıl :
2020
Covid-19 and Neurology Coronavirus disease- 19 ( COVID- 19) pandemic is a new and important burden for the neurological area. mechanisms of neurological involvement of the disease may be explained more efficiently by neurologists who are included within the multidisciplinary COVID - 19 teams. covid-19
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Neurological diseases are the most common and important health burden over the world. Coronavirus disease-19 (COVID-19) pandemic is a new and important burden for the neurological area. Information related to the neurological involvement of Severe Acute Respiratory syndrome-Coronavirus-2 infection has been increased during the last several months. Frequency and mechanisms of neurological involvement of the disease may be explained more efficiently by neurologists who are included within the multidisciplinary COVID-19 teams. Other very important point is possibility of failure of follow up and treatment of chronic neurological disorders which needed frequent and regular control and also quick action for the acute treatment. The regulations are extremely important for the neurologists to perform their responsibilities with considering all these requirements.
DOI : 10.4274/tnd.2020.73384
Anahtar Kelimeler : covid-19, neurology, turkey
Cilt: 26
Sayı: 2
Sayfa: 109 - 111
Sınıflandırma :
24
COVID-19 and epilepsy
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Annals of Indian Academy of Neurology
Yazar(lar) :
Sora Yasri , Viroj Wiwanikit
Yıl :
2020
COVID-19 and epilepsy
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DOI : 10.4103/aian.AIAN_254_20
Cilt: 23
Sayı: 7
Sayfa: 43 - 43
Sınıflandırma :
25
Coping with COVID-19
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Lumbini Medical College
Yazar(lar) :
Bhagavat Nepal , Prof
Yıl :
2020
Coping with COVID-19 Antivirals, specifically Remdesivir has been a strong candidate for the treatment of COVID- 19. However, it has yet to receive universal acceptance for the treatment of COVID- 19. These findings suggest the hypothesis that anti-malarial drugs have efficacy in the treatment of COVID- 19. COVID 19
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Severe acute respiratory syndrome corona virus (SARS-CoV-2) virus made its first appearance in Wuhan, China in December 2019. It has since spread like a wild fire across the globe with over five million corona virus disease (COVID-19) confirmed cases and almost three hundred fifty thousand deaths at the time of writing this article. This could however be only the tip of the iceberg considering the contagious nature of the SARS-CoV-2 virus and the rate at which it is spreading across the globe. China did well to contain the virus with strict lockdown measures, sealing the affected areas, active case finding, tracing, tracking and treating the COVID-19 cases at an astonishing speed. In the absence of specific treatment available as yet, treatment consists of mainly symptomatic management with some experimental medications. Antivirals, specifically Remdesivir has been a strong candidate for the treatment of COVID-19. However, it has yet to receive universal acceptance for the treatment of COVID-19. Chloroquine and Hydroxychloroquine seem to be effective in limiting the replication of SARS-CoV-2 virus in vitro. COVID-19 is highly pandemic in countries where malaria is least prevalent and least pandemic in countries where malaria is highly prevalent. These findings suggest the hypothesis that anti-malarial drugs have efficacy in the treatment of COVID-19.
DOI : 10.22502/jlmc.v8i1.355
Anahtar Kelimeler : COVID 19
Cilt: 8
Sayı: 1
Sınıflandırma :
26
Acceptance of COVID-19 Vaccination during the COVID-19 Pandemic in China
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Vaccines
Yazar(lar) :
Jiahao Wang , Rize Jing , Xiaozhen Lai , Haijun Zhang , Yun Lyu , Maria Deloria Knoll , Hai Fang
Yıl :
2020
Acceptance of COVID-19 Vaccination during the COVID-19 Pandemic in China Background: Faced with the coronavirus disease 2019 ( COVID- 19) pandemic, the development of COVID- 19 vaccines has been progressing at an unprecedented of vaccines against COVID- 19 during the pandemic. - 19 vaccination or valuing doctor’s recommendations could increase the probability of accepting COVID- 19 vaccination as soon as possible, while having COVID-19
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Background: Faced with the coronavirus disease 2019 (COVID-19) pandemic, the development of COVID-19 vaccines has been progressing at an unprecedented rate. This study aimed to evaluate the acceptance of COVID-19 vaccination in China and give suggestions for vaccination strategies and immunization programs accordingly. Methods: In March 2020, an anonymous cross-sectional survey was conducted online among Chinese adults. The questionnaire collected socio-demographic characteristics, risk perception, the impact of COVID-19, attitudes, acceptance and attribute preferences of vaccines against COVID-19 during the pandemic. Multivariate logistic regression was performed to identify the influencing factors of vaccination acceptance. Results: Of the 2058 participants surveyed, 1879 (91.3%) stated that they would accept COVID-19 vaccination after the vaccine becomes available, among whom 980 (52.2%) wanted to get vaccinated as soon as possible, while others (47.8%) would delay the vaccination until the vaccine’s safety was confirmed. Participants preferred a routine immunization schedule (49.4%) to emergency vaccination (9.0%) or either of them (41.6%). Logistic regression showed that being male, being married, perceiving a high risk of infection, being vaccinated against influenza in the past season, believing in the efficacy of COVID-19 vaccination or valuing doctor’s recommendations could increase the probability of accepting COVID-19 vaccination as soon as possible, while having confirmed or suspected cases in local areas, valuing vaccination convenience or vaccine price in decision-making could hinder participants from immediate vaccination. Conclusion: During the pandemic period, a strong demand for and high acceptance of COVID-19 vaccination has been shown among the Chinese population, while concerns about vaccine safety may hinder the promotion of vaccine uptake. To expand vaccination coverage, immunization programs should be designed to remove barriers in terms of vaccine price and vaccination convenience, and health education and communication from authoritative sources are important ways to alleviate public concerns about vaccine safety.
DOI : 10.3390/vaccines8030482
Anahtar Kelimeler : SARS-CoV-2, COVID-19, immunization, vaccine acceptance, vaccine preference
ISSN: 2076-393X
Cilt: 8
Sayı: 482
Sayfa: 482
Sınıflandırma :
27
Learning COVID-19 network from literature databases using core decomposition
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Yang Guo
Yıl :
2021
Learning COVID-19 network from literature databases using core decomposition - 19. In addition, we compile a comprehensive list of novel genes, and proteins potentially related to COVID- 19, as well as novel diseases which might be comorbidities Together with the generated hypotheses, our results provide novel knowledge relevant to COVID- 19 for further validation. / Graduate COVID-19
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The SARS-CoV-2 coronavirus is responsible for millions of deaths around the world. To help contribute to the understanding of crucial knowledge and to further generate new hypotheses relevant to SARS-CoV-2 and human protein interactions, we make use of the information abundant Biomine probabilistic database and extend the experimentally identified SARS-CoV-2-human protein-protein interaction (PPI) network in silico. We generate an extended network by integrating information from the Biomine database and the PPI network. To generate novel hypotheses, we focus on the high-connectivity sub-communities that overlap most with the PPI network in the extended network. Therefore, we propose a new data analysis pipeline that can efficiently compute core decomposition on the extended network and identify dense subgraphs. We then evaluate the identified dense subgraph and the generated hypotheses in three contexts: literature validation for uncovered virus targeting genes and proteins, gene function enrichment analysis on subgraphs, and literature support on drug repurposing for identified tissues and diseases related to COVID-19. The majority types of the generated hypotheses are proteins with their encoding genes and we rank them by sorting their connections to known PPI network nodes. In addition, we compile a comprehensive list of novel genes, and proteins potentially related to COVID-19, as well as novel diseases which might be comorbidities. Together with the generated hypotheses, our results provide novel knowledge relevant to COVID-19 for further validation. / Graduate
Anahtar Kelimeler : COVID-19, Core Decomposition, Network Inference, Data Mining, Graph Theory
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