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Pharmaceutical industry before COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Farmacja Polska
Yazar(lar) :
Krzysztof Woyna-Orlewicz , Renata Jachowicz
Yıl :
2020
Pharmaceutical industry before COVID-19
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The 2019 CPhI Annual Report describing rankings, innovations and key trends in pharma industry is summarized. Pharmaceutical markets were assessed based on an the following indicators: growth potential, API manufacturing, innovation, competitiveness and finished product. The top three markets are USA, Germany and Japan, while China has made the largest overall improvement. Interestingly, UK demonstrated the largest growth decrease of all the markets reported. The fact is attributed to Brexit. The winner of CPhI Award was PolarDry® Electrostatic Spray Dryer. Thanks electrostatic induction applied in spraying nozzle, polar solvent is moved to the surface and non-polar ingredients into center of droplets. The most promising recent drug delivery devices were drug patches, smart dose injectors, multi-dose delivery injectable caps and smart dry powder inhalers. The most anticipated drug delivery devices are needle-free devices, wearable delivery devices, pre-filled syringes and dual chamber products as well as autoinjectors and pens. A few preselected articles were briefly summarized. Bikash Chatterjee from Pharmatech Associates described evolution of industry called Pharma 4.0. The key assumptions are gathering of data from across the global supply chain by smart sensors and devices referred to Internet of Things, the data evaluation by applying Artificial Intelligence tools and finally complete integration of databases. Mr. Girish Malhotra presented trends in global quality assurance. The following worth to be highlighted: necessity of technological improvements in manufacturing oriented on costs optimization and the highest possible drug products quality, standardization of requirements for drug products quality assessment. The regulatory agencies are oriented to enforce changes implementation by hesitant companies. D.M. Ecker and P.Seymur from BioProcess Technology Group presented „Mammalian Biomanufacutring Industry Overview”. Vicky Qing Xia described rapidly growing biotechnological market of China. M.E.Ultee paid attention on developing gene therapies market in US.
DOI : 10.32383/farmpol/125555
Anahtar Kelimeler : economic development, drug development, drug industry
Cilt: 76
Sayı: 5
Sayfa: 269 - 274
Sınıflandırma :
2
A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Molecular Sciences
Yazar(lar) :
Franklin Wang-Ngai Chow , Tony Tat-Yin Chan , Anthony Raymond Tam , Suhui Zhao , Weiming Yao , Joshua Fung , Flora Ka-Kei Cheng , George Chi-Shing Lo , Stella Chu , Kam Leng Aw-Yong , James Yat-Man Tang , Chi-Ching Tsang , Hayes Kam-Hei Luk , Antonio Cheuk-Pui Wong , Kenneth Sze-Ming Li , Longchao Zhu , Zirong He , Emily Wan Ting Tam , Tom Wai-Hin Chung , Sally Cheuk Ying Wong , Tak-Lun Que , Kitty Sau-Chun Fung , David Christopher Lung , Alan Ka-Lun Wu , Ivan Fan-Ngai Hung , Patrick Chiu-Yat Woo , Susanna Kar-Pui Lau
Yıl :
2020
A Rapid, Simple, Inexpensive, and Mobile Colorimetric Assay COVID-19-LAMP for Mass On-Site Screening of COVID-19 To control the COVID- 19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, a method for a rapid, simple, and inexpensive COVID- 19-LAMP can detect SARS-CoV-2 RNA with detection limit of 42 copies/reaction. None of the 143 samples with other respiratory viruses were positive by COVID- 19-LAMP, showing 100% specificity. COVID-19
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Kaydet Alıntıla
To control the COVID-19 pandemic and prevent its resurgence in areas preparing for a return of economic activities, a method for a rapid, simple, and inexpensive point-of-care diagnosis and mass screening is urgently needed. We developed and evaluated a one-step colorimetric reverse-transcriptional loop-mediated isothermal amplification assay (COVID-19-LAMP) for detection of SARS-CoV-2, using SARS-CoV-2 isolate and respiratory samples from patients with COVID-19 (n = 223) and other respiratory virus infections (n = 143). The assay involves simple equipment and techniques and low cost, without the need for expensive qPCR machines, and the result, indicated by color change, is easily interpreted by naked eyes. COVID-19-LAMP can detect SARS-CoV-2 RNA with detection limit of 42 copies/reaction. Of 223 respiratory samples positive for SARS-CoV-2 by qRT-PCR, 212 and 219 were positive by COVID-19-LAMP at 60 and 90 min (sensitivities of 95.07% and 98.21%) respectively, with the highest sensitivities among nasopharyngeal swabs (96.88% and 98.96%), compared to sputum/deep throat saliva samples (94.03% and 97.02%), and throat swab samples (93.33% and 98.33%). None of the 143 samples with other respiratory viruses were positive by COVID-19-LAMP, showing 100% specificity. Samples with higher viral load showed shorter detection time, some as early as 30 min. This inexpensive, highly sensitive and specific COVID-19-LAMP assay can be useful for rapid deployment as mobile diagnostic units to resource-limiting areas for point-of-care diagnosis, and for unlimited high-throughput mass screening at borders to reduce cross-regional transmission.
DOI : 10.3390/ijms21155380
Anahtar Kelimeler : COVID-19, RT-LAMP, SARS-CoV-2, mass screening, on-site screening, diagnosis
Cilt: 21
Sayı: 5380
Sayfa: 5380
Sınıflandırma :
Viroloji %100
3
COVID-19 Sample Info Form V. 2.0 fill-able
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Yazar(lar) :
Ahmed Shareef
Yıl :
2020
COVID-19 Sample Info Form V. 2.0 fill-able covid- 19-sample-info-form-v.-2.0
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covid-19-sample-info-form-v.-2.0
Sınıflandırma :
4
Digital solutions to combat Covid-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Filtration + Separation
Yayıncı:
Elsevier
Yıl :
2020
Digital solutions to combat Covid-19 Albert Cho, vice president and general manager at Xylem, discusses how utilities are responding to Covid- 19, the digital technologies that are assisting
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Kaydet Alıntıla
Albert Cho, vice president and general manager at Xylem, discusses how utilities are responding to Covid-19, the digital technologies that are assisting operational continuity and what the pandemic means for the future of utility management.
DOI : 10.1016/s0015-1882(20)30060-4
ISSN: 0015-1882
Sayı: 2
Cilt: 57
Sayfa: 16-18
Sınıflandırma :
5
Development of Point-of-Care Biosensors for COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Chemistry
Yazar(lar) :
Jane Ru Choi , Jane Ru Choi
Yıl :
2020
Development of Point-of-Care Biosensors for COVID-19 Coronavirus disease 2019 ( COVID- 19) outbreak has become a global pandemic. This mini review article discusses the recent advances in POC biosensors for COVID- 19. The advantages of each biosensors along with the commercially available COVID- 19 biosensors are highlighted. COVID-19
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
Coronavirus disease 2019 (COVID-19) outbreak has become a global pandemic. The deleterious effects of coronavirus have prompted the development of diagnostic tools to manage the spread of disease. While conventional technologies such as quantitative real time polymerase chain reaction (qRT-PCR) have been broadly used to detect COVID-19, they are time-consuming, labor-intensive and are unavailable in remote settings. Point-of-care (POC) biosensors, including chip-based and paper-based biosensors are typically low-cost and user-friendly, which offer tremendous potential for rapid medical diagnosis. This mini review article discusses the recent advances in POC biosensors for COVID-19. First, the development of POC biosensors which are made of polydimethylsiloxane (PDMS), papers, and other flexible materials such as textile, film, and carbon nanosheets are reviewed. The advantages of each biosensors along with the commercially available COVID-19 biosensors are highlighted. Lastly, the existing challenges and future perspectives of developing robust POC biosensors to rapidly identify and manage the spread of COVID-19 are briefly discussed.
DOI : 10.3389/fchem.2020.00517
Anahtar Kelimeler : POC biosensors, paper, flexible materials, COVID-19
ISSN: 2296-2646
Cilt: 8
Sınıflandırma :
6
Extracorporeal membrane oxygenation programs for COVID-19 in China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Critical Care
Yazar(lar) :
Chenglong Li , Xiaotong Hou , Zhaohui Tong , Haibo Qiu , Yimin Li , Ang Li , Chinese Society of Extracorporeal Life Support (CSECLS)
Yıl :
2020
Extracorporeal membrane oxygenation programs for COVID-19 in China
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1186/s13054-020-03047-6
Cilt: 24
Sayı: 1
Sayfa: 1 - 4
Sınıflandırma :
7
Antimicrobial Photodynamic Therapy in the Control of COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Antibiotics
Yazar(lar) :
Adelaide Almeida , M. Amparo F. Faustino , Maria G. P. M. S. Neves
Yıl :
2020
Antimicrobial Photodynamic Therapy in the Control of COVID-19 ., protoporphyrin-IX (PP-IX), might help to mitigate the COVID- 19 either to prevent infections or to develop photoactive fabrics (e.g., masks, suits, gloves COVID-19
Piri Tam Metin Bulucu
Kaydet Alıntıla
Antimicrobial photodynamic therapy (aPDT), using well known, safe and cost-effective photosensitizers, such as phenothiazines, e.g., methylene blue (MB), or porphyrins, e.g., protoporphyrin-IX (PP-IX), might help to mitigate the COVID-19 either to prevent infections or to develop photoactive fabrics (e.g., masks, suits, gloves) to disinfect surfaces, air and wastewater, under artificial light and/or natural sunlight.
DOI : 10.3390/antibiotics9060320
Anahtar Kelimeler : antimicrobial photodynamic therapy, coronaviruses, SARS-CoV-2, COVID-19, control, disinfection
ISSN: 2079-6382
Cilt: 9
Sayı: 320
Sayfa: 320
Sınıflandırma :
8
Didemnins Inhibit COVID-19 Main Protease (Mpro)
Dergi Makalesi

Dergi Makalesi
Kaynak :
DSpace Makaleler
Yazar(lar) :
SELMİHAN ŞAHİN , Furkan Calapoğlu , İSMAİL ÖZMEN
Yıl :
2021
Didemnins Inhibit COVID-19 Main Protease (Mpro)
Kaydet Alıntıla
Sınıflandırma :
Kimya %100
Tıbbi Kimya %85
9
Structural dynamics of COVID-19 main protease
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Molecular Structure
Yayıncı:
Elsevier
Yazar(lar) :
Ashkan Shekaari , Mahmoud Jafari
Yıl :
2021
Structural dynamics of COVID-19 main protease coronaviridae, we have carried out an in silico investigation on the biologically important, yet unmapped phenomenon of activity and internal dynamics of COVID - 19 main protease (Mpro) via applying finite-temperature all-atom molecular dynamics simulations. - 19 main protease. COVID-19 main protease
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Based on the importance of protease enzymes in functioning some viruses particularly coronaviridae, we have carried out an in silico investigation on the biologically important, yet unmapped phenomenon of activity and internal dynamics of COVID-19 main protease (Mpro) via applying finite-temperature all-atom molecular dynamics simulations. Temperature quench echoes generated by applying two successive cooling signals have therefore been analyzed in terms of the temperature-temperature correlation function of the protease within the harmonic approximation. An exponentially decaying brand of behavior has been found for the calculated echo depth values with increasing time, which has accordingly led to a much small dephasing time of about 150 fs, revealing a significant anharmonicity and therefore an overall structural stiffness for the COVID-19 main protease.
DOI : 10.1016/j.molstruc.2020.129235
Anahtar Kelimeler : COVID-19 main protease, Internal dynamics, Normal modes
ISSN: 0022-2860
Cilt: 1223
Sayfa: 129235
Sınıflandırma :
10
COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM
Konferans Makalesi

Konferans Makalesi
Kaynak :
DSpace Makaleler
Yazar(lar) :
Betül Aycan Alim
Konu :
Alim B. A. , -COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM-, 3rd INTERNATIONAL CONFERENCE ON COVID-19 STUDIES, Ankara, Türkiye, 25 - 27 Aralık 2020
Yıl :
2020
COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM . , -COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM-, 3rd INTERNATIONAL CONFERENCE ON COVID-19 STUDIES, Ankara, Türkiye, 25 - 27 Aralık 2020 -COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM- 3rd INTERNATIONAL CONFERENCE ON COVID-19 STUDIES
Kaydet Alıntıla
Anahtar Kelimeler : Alim B. A., -COVID-19 PANDEMİSİNDE ACİL ENDODONTİK TEDAVİLERE YAKLAŞIM-, 3rd INTERNATIONAL CONFERENCE ON COVID-19 STUDIES, Ankara, Türkiye, 25 - 27 Aralık 2020, Conference Paper
Sınıflandırma :
Kimya %74
11
Could PROTACs Protect Us From COVID-19?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Drug Discovery Today
Yayıncı:
Elsevier
Yazar(lar) :
Wilnelly Martinez-Ortiz , Ming-Ming Zhou
Yıl :
2020
Could PROTACs Protect Us From COVID-19?
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Kaydet Alıntıla
DOI : 10.1016/j.drudis.2020.08.007
ISSN: 1359-6446

Sınıflandırma :
12
Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archives of Medical Research
Yayıncı:
Elsevier
Yazar(lar) :
Undurti N. Das
Yıl :
2020
Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?
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Kaydet Alıntıla
SARS-CoV-2, SARS and MERS are all enveloped viruses that can cause acute respiratory syndrome. Arachidonic acid (AA) and other unsaturated fatty acids (especially eicosapentaenoic acd, EPA and docosahexaenoic acid DHA) are known to inactivate enveloped viruses and inhibit proliferation of various microbial organisms. The pro-inflammatory metabolites of AA and EPA such as prostaglandins, leukotrienes and thromboxanes induce inflammation whereas lipoxins, resolvins, protectins and maresins derived from AA, EPA and DHA not only suppress inflammation but also enhance would healing and augment phagocytosis of macrophages and other immunocytes and decrease microbial load. In view of these actions, it is suggested that AA and other unsaturated fatty acids and their metabolites may serve as endogenous anti-viral compounds and their deficiency may render humans susceptible to SARS-CoV-2, SARS and MERS and other similar viruses’ infections. Hence, oral or intravenous administration of AA and other unsaturated fatty acids may aid in enhancing resistance and recovery from SARS-CoV-2, SARS and MERS infections.
DOI : 10.1016/j.arcmed.2020.03.004
Anahtar Kelimeler : SARS-CoV-2, SARS, MERS, Polyunsaturated fatty acids, Arachidonic acid, Prostaglandins, Lipoxin A4, Resolvins, Protectins and maresins, Inflammation
ISSN: 0188-4409
Sayı: 3
Cilt: 51
Sayfa: 282-286
Sınıflandırma :
13
Contingent assessment of the COVID-19 vaccine
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Vaccine
Yayıncı:
Elsevier
Yazar(lar) :
Leidy Y. García , Arcadio A. Cerda
Yıl :
2020
Contingent assessment of the COVID-19 vaccine The COVID- 19 pandemic has not only had a negative impact on people’s health and life behavior, but also on economies around the world. At the same time, laboratories and institutions are working hard to obtain a COVID- 19 vaccine, which we hope will be available soon. The main results showed that the WTP depends on the preexistence of chronic disease ( p≤0.05), knowledge of COVID- 19 ( p≤0.05), being sick with COVID- 19 COVID-19
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The COVID-19 pandemic has not only had a negative impact on people’s health and life behavior, but also on economies around the world. At the same time, laboratories and institutions are working hard to obtain a COVID-19 vaccine, which we hope will be available soon. However, there has been no assessment of whether an individual and society value a vaccine monetarily, and what factors determine this value. Therefore, the objective of this research was to estimate the individual’s willingness to pay (WTP) for a hypothetical COVID-19 vaccine and, at the same time, find the main factors that determine this valuation. For this, we used the contingent valuation approach, in its single and double-bounded dichotomous choice format, which was based on a hypothetical market for a vaccine. The sample used was obtained through an online survey of n = 566 individuals from Chile. The main results showed that the WTP depends on the preexistence of chronic disease ( p≤0.05), knowledge of COVID-19 ( p≤0.05), being sick with COVID-19 ( p≤0.05), perception of government performance ( p≤0.01), employment status ( p≤0.01), income ( p≤0.01), health care ( p≤0.05), adaptation to quarantine with children at home ( p≤0.01) and whether the person has recovered from COVID-19 ( p≤0.10). According to our discrete choice model in double-bounded dichotomous format, it was concluded that the individuals’ WTP is US$184.72 (CI: 165.52–203.92; p < 0.01). This implies a social valuation of approximately US$2232 million, corresponding to 1.09% of the GNP per capita.
DOI : 10.1016/j.vaccine.2020.06.068
Anahtar Kelimeler : COVID-19, SARS-CoV-2, Vaccine, Acceptance, Health economics, Contingent valuation
ISSN: 0264-410X
Sayı: 34
Cilt: 38
Sayfa: 5424-5429
Sınıflandırma :
14
An Antioxidant Enzyme Therapeutic for COVID‐19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Advanced Materials
Yazar(lar) :
Meng Qin , Zheng Cao , Jing Wen , Qingsong Yu , Chaoyong Liu , Fang Wang , Jianjun Zhang , Fengmei Yang , Yanyan Li , Gregory Fishbein , Sen Yan , Bin Xu , Yi Hou , Zhenbo Ning , Kaili Nie , Ni Jiang , Zhen Liu , Jun Wu , Yanting Yu , Heng Li , Huiwen Zheng , Jing Li , Weihua Jin , Shen Pang , Shuai Wang , Jianfeng Chen , Zhihua Gan , Zhanlong He , Yunfeng Lu
Konu :
Mechanical Engineering, General Materials Science, Mechanics of Materials
Yıl :
2020
An Antioxidant Enzyme Therapeutic for COVID‐19 The COVID‐ 19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID‐ 19.
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The COVID‐19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS‐CoV‐2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID‐19.
DOI : 10.1002/adma.202004901
ISSN: 0935-9648
Sayı: 43
Cilt: 32
Sayfa: 2004901
Sınıflandırma :
15
Surviving the storm: Dealing with COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Cellular Immunology
Yayıncı:
Elsevier
Yazar(lar) :
Arthur A. Vandenbark , Roberto Meza-Romero , Halina Offner
Yıl :
2020
Surviving the storm: Dealing with COVID-19
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DOI : 10.1016/j.cellimm.2020.104153
ISSN: 0008-8749
Cilt: 354
Sayfa: 104153
Sınıflandırma :
16
The role of IgA in COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Brain, Behavior, and Immunity
Yayıncı:
Elsevier
Yazar(lar) :
Yin Xia Chao , Olaf Rötzschke , Eng-King Tan
Yıl :
2020
The role of IgA in COVID-19
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DOI : 10.1016/j.bbi.2020.05.057
ISSN: 0889-1591
Cilt: 87
Sayfa: 182-183
Sınıflandırma :
17
Saliva for the diagnosis of COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Taylor and Francis
Dergi:
Applied Spectroscopy Reviews
Yazar(lar) :
Rabia Sannam Khan , Hamza Ur Rehman , Ihtesham Ur Rehman
Konu :
Instrumentation, Spectroscopy
Yıl :
2020
Saliva for the diagnosis of COVID-19 COVID-19
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Kaydet Alıntıla
DOI : 10.1080/05704928.2020.1809442
Anahtar Kelimeler : Saliva, diagnosis, COVID-19
ISSN: 0570-4928
Sayı: 9-10
Cilt: 55
Sayfa: 805-809
Sınıflandırma :
18
COVID-19 diagnosis —A review of current methods
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Biosensors and Bioelectronics
Yayıncı:
Elsevier
Yazar(lar) :
Meral Yüce , Elif Filiztekin , Korin Gasia Özkaya
Yıl :
2021
COVID-19 diagnosis —A review of current methods A fast and accurate self-testing tool for COVID- 19 diagnosis has become a prerequisite to comprehend the exact number of cases worldwide and to take medical COVID-19
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Kaydet Alıntıla
A fast and accurate self-testing tool for COVID-19 diagnosis has become a prerequisite to comprehend the exact number of cases worldwide and to take medical and governmental actions accordingly. SARS-CoV-2 (formerly, 2019-nCoV) infection was first reported in Wuhan (China) in December 2019, and then it has rapidly spread around the world, causing ~14 million active cases with ~582,000 deaths as of July 2020. The diagnosis tools available so far have been based on a) viral gene detection, b) human antibody detection, and c) viral antigen detection, among which the viral gene detection by RT-PCR has been found as the most reliable technique. In this report, the current SARS-CoV-2 detection kits, exclusively the ones that were issued an “Emergency Use Authorization” from the U.S. Food and Drug Administration, were discussed. The key structural components of the virus were presented to provide the audience with an understanding of the scientific principles behind the testing tools. The methods that are still in the early research state were also reviewed in a subsection based on the reports available so far.
DOI : 10.1016/j.bios.2020.112752
Anahtar Kelimeler : COVID-19, SARS-CoV-2 diagnosis, SARS-CoV-2 detection, RT-PCR, Lateral flow assay, Loop-mediated isothermal amplification, Point of care devices
ISSN: 0956-5663
Cilt: 172
Sayfa: 112752
Sınıflandırma :
19
Tackle the free radicals damage in COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Nitric Oxide
Yayıncı:
Elsevier
Yazar(lar) :
Jun Wu
Yıl :
2020
Tackle the free radicals damage in COVID-19 We know very little about the pathogenesis of SARS-CoV-2, the virus which induces the COVID- 19. However, COVID- 19 does share many similar symptoms with SARS and influenza. Astonishingly very few medical professionals mention the crucial role of free radical damage in COVID- 19. COVID-19
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Kaydet Alıntıla
COVID-19 is a severe pandemic which has caused a devastating amount of loss in lives around the world, and yet we still don't know how to appropriately treat this disease. We know very little about the pathogenesis of SARS-CoV-2, the virus which induces the COVID-19. However, COVID-19 does share many similar symptoms with SARS and influenza. Previous scientific discoveries learned from lab animal models and clinical practices shed light on possible pathogenic mechanisms in COVID-19. In the past decades, accumulated scientific findings confirmed the pathogenic role of free radicals damage in respiratory virus infection. Astonishingly very few medical professionals mention the crucial role of free radical damage in COVID-19. This hypothesis aims to summarize the crucial pathogenic role of free radical damage in respiratory virus induced pneumonia and suggest an antioxidative therapeutic strategy for COVID-19.
DOI : 10.1016/j.niox.2020.06.002
Anahtar Kelimeler : COVID-19, Free radicals, Cytokine storm, Nitric oxide, Superoxide
ISSN: 1089-8603
Cilt: 102
Sayfa: 39-41
Sınıflandırma :
20
Review on 3D printing: Fight against COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Materials Chemistry and Physics
Yayıncı:
Elsevier
Yazar(lar) :
Bankole I. Oladapo , Sikiru O. Ismail , Temitope D. Afolalu , David B. Olawade , Mohsen Zahedi
Yıl :
2021
Review on 3D printing: Fight against COVID-19 To date, there are no specific, clinically significant licensed drugs and vaccines available for COVID- 19. This study is a review of the work done till October, 2020 on solving COVID- 19 with 3D printing. - 19 test and personal protective equipment (PPE) to reduce the effect of COVID- 19 on the world economy. COVID-19 pandemic
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Kaydet Alıntıla
The outbreak of coronavirus disease in 2019 (COVID-19) caused by the SARS-CoV-2 virus and its pandemic effects have created a demand for essential medical equipment. To date, there are no specific, clinically significant licensed drugs and vaccines available for COVID-19. Hence, mapping out COVID-19 problems and preventing the spread with relevant technology are very urgent. This study is a review of the work done till October, 2020 on solving COVID-19 with 3D printing. Many patients who need to be hospitalized because of COVID-19 can only survive on bio-macromolecules antiviral respiratory assistance and other medical devices. A bio-cellular face shield with relative comfortability made of bio-macromolecules polymerized polyvinyl chloride (BPVC) and other biomaterials are produced with 3D printers. Summarily, it was evident from this review study that additive manufacturing (AM) is a proffered technology for efficient production of an improved bio-macromolecules capable of significant COVID-19 test and personal protective equipment (PPE) to reduce the effect of COVID-19 on the world economy. Innovative AM applications can play an essential role to combat invisible killers (COVID-19) and its hydra-headed pandemic effects on humans, economics and society.
DOI : 10.1016/j.matchemphys.2020.123943
Anahtar Kelimeler : Additive manufacturing/3D printing, COVID-19 pandemic, PPE, Medical devices, Health
ISSN: 0254-0584
Cilt: 258
Sayfa: 123943
Sınıflandırma :
21
Facile biosensors for rapid detection of COVID-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Biosensors and Bioelectronics
Yayıncı:
Elsevier
Yazar(lar) :
Lizhou Xu , Danyang Li , Sami Ramadan , Yanbin Li , Norbert Klein
Yıl :
2020
Facile biosensors for rapid detection of COVID-19 Currently the world is being challenged by a public health emergency caused by the coronavirus pandemic ( COVID- 19). This review summarises recent advances in strategies reported by international researchers and engineers concerning how to tackle COVID- 19 via rapid testing - 19. COVID-19
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Kaydet Alıntıla
Currently the world is being challenged by a public health emergency caused by the coronavirus pandemic (COVID-19). Extensive efforts in testing for coronavirus infection, combined with isolating infected cases and quarantining those in contact, have proven successful in bringing the epidemic under control. Rapid and facile screening of this disease is in high demand. This review summarises recent advances in strategies reported by international researchers and engineers concerning how to tackle COVID-19 via rapid testing, mainly through nucleic acid- and antibody- testing. The roles of biosensors as powerful analytical tools are emphasized for the detection of viral RNAs, surface antigens, whole viral particles, antibodies and other potential biomarkers in human specimen. We critically review in depth newly developed biosensing methods especially for in-field and point-of-care detection of SARS-CoV-2. Additionally, this review describes possible future strategies for virus rapid detection. It helps researchers working on novel sensor technologies to tailor their technologies in a way to address the challenge for effective detection of COVID-19.
DOI : 10.1016/j.bios.2020.112673
Anahtar Kelimeler : SARS-CoV-2, COVID-19, Rapid detection, Point-of-care testing, Coronavirus, Biosensor
ISSN: 0956-5663
Cilt: 170
Sayfa: 112673
Sınıflandırma :
22
COVID-19 and the food industry: Readiness assessment
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Food Control
Yayıncı:
Elsevier
Yazar(lar) :
Zeina Nakat , Christelle Bou-Mitri
Yıl :
2021
COVID-19 and the food industry: Readiness assessment The COVID- 19 pandemic has hit hard on the world economy and global health. This literature review aims at assembling all current knowledge about COVID- 19 and its impact on the food industry. COVID-19
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The COVID-19 pandemic has hit hard on the world economy and global health. Where most businesses are completely closed following governments restrictions, the food sector across the supply chain must remain operational in order to feed the nations. In such a challenging time, keeping the workers healthy and safe is critical while maintaining a high level of food safety and consumer confidence. Against a backdrop of heightened uncertainty, up-to-date and reliable information is more important than ever, both for regulators and this sector. This literature review aims at assembling all current knowledge about COVID-19 and its impact on the food industry. It is an exhaustive compilation of relevant public information and guidance published by the World Health Organization (WHO), and collected from 11 governmental and 10 non-governmental sources as well as 25 peer-reviewed articles published in scientific journals since the beginning of the crisis till June 5th, 2020. This paper could be of assistance to educators, researchers, and policy makers. It could also serve as an assessment tool to ensure business continuity and to determine the level of food industry readiness providing reassurance to all stakeholders during these unprecedented times.
DOI : 10.1016/j.foodcont.2020.107661
Anahtar Kelimeler : COVID-19, Food safety, Guidance, cGMP, Occupational safety and health, Food industry, Risk assessment.
ISSN: 0956-7135
Cilt: 121
Sayfa: 107661
Sınıflandırma :
23
Market outlook: post-COVID-19, what will change?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Focus on Catalysts
Yayıncı:
Elsevier
Yıl :
2020
Market outlook: post-COVID-19, what will change?
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DOI : 10.1016/j.focat.2020.06.018
ISSN: 1351-4180
Sayı: 7
Cilt: 2020
Sayfa: 3-4
Sınıflandırma :
24
The role of electrospun nanofibers in the fight against the COVID-19
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
eXPRESS Polymer Letters
Yazar(lar) :
K. Molnar , L. Meszaros
Yıl :
2020
The role of electrospun nanofibers in the fight against the COVID-19
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DOI : 10.3144/expresspolymlett.2020.49
Anahtar Kelimeler : nanomaterials, coronavirus, nanofiber, electrospinning
ISSN: 1788-618X
Cilt: 14
Sayı: 7
Sayfa: 605 - 605
Sınıflandırma :
25
Sensitivity of the Wondfo One Step COVID-19 test using serum samples
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Clinics
Yazar(lar) :
Vera Aparecida dos Santos , Mayra Matias Rafael , Ester Cerdeira Sabino , Alberto José da Silva Duarte
Sensitivity of the Wondfo One Step COVID-19 test using serum samples
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DOI : 10.6061/clinics/2020/e2013
Cilt: 75
Sınıflandırma :
Kimya %46
Nanokimya %63
Biyotıp %92
26
Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Pharmaceuticals
Yazar(lar) :
Aleksandra Hecel , Małgorzata Ostrowska , Kamila Stokowa-Sołtys , Joanna Wątły , Dorota Dudek , Adriana Miller , Sławomir Potocki , Agnieszka Matera-Witkiewicz , Alicia Dominguez-Martin , Henryk Kozłowski , Magdalena Rowińska-Żyrek
Yıl :
2020
Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19? We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID- 19, as well as earlier reports Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID- 19 therapeutics. COVID-19
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Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.
DOI : 10.3390/ph13090228
Anahtar Kelimeler : COVID-19, SARS-CoV-2, 2019-nCoV, Zn(II) ionophores, chloroquine, hydroxy- chloroquine
ISSN: 1424-8247
Cilt: 13
Sayı: 228
Sayfa: 228
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