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Are children less susceptible to COVID-19?
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Microbiology, Immunology and Infection
Yazar(lar) :
Ping-Ing Lee , Ya-Li Hu , Po-Yen Chen , Yhu-Chering Huang , Po-Ren Hsueh
Yıl :
2020
Are children less susceptible to COVID-19?
Kaydet Alıntıla
ISSN: 1684-1182
Cilt: 53
Sayı: 3
Sayfa: 371 - 372
Sınıflandırma :
2
COVID-19 PCR Testing Update From Missouri DHSS
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Yazar(lar) :
Missouri Department of Health and Senior Services
Yıl :
2020
COVID-19 PCR Testing Update From Missouri DHSS COVID- 19 PCR Testing Update From Missouri DHSS; coronavirus; testing criteria; symptoms; communicable diseases; health care; clinicians; epidemiology;
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COVID-19 PCR Testing Update From Missouri DHSS; coronavirus; testing criteria; symptoms; communicable diseases; health care; clinicians; epidemiology; Show Me Strong
3
Myasthenic crisis in COVID-19
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of the Neurological Sciences
Yayıncı:
Elsevier
Yazar(lar) :
Fadi Delly , Maryam J. Syed , Robert P. Lisak , Deepti Zutshi
Yıl :
2020
Myasthenic crisis in COVID-19 COVID-19
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DOI : 10.1016/j.jns.2020.116888
Anahtar Kelimeler : Viral infection, Myasthenia, COVID-19
ISSN: 0022-510X
Cilt: 414
Sayfa: 116888
Sınıflandırma :
4
Liver Injury in COVID-19: Caution and Management
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Liver Cancer
Yazar(lar) :
Jiasheng Cao , Xiujun Cai , Mingyu Chen
Yıl :
2020
Liver Injury in COVID-19: Caution and Management
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DOI : 10.1159/000508696
Sayfa: 1 - 2
Sınıflandırma :
5
Neurological manifestations in COVID-19: A narrative review
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
SAGE Open Medicine
Yazar(lar) :
Asma Rahman , Roshan Niloofa , Ishan M De Zoysa , Akila D Cooray , Jayani Kariyawasam , Suranjith L Seneviratne
Yıl :
2020
Neurological manifestations in COVID-19: A narrative review COVID- 19, a respiratory viral infection, has affected more than 10 million individuals worldwide. We have outlined the common neurological manifestations in COVID- 19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic
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COVID-19, a respiratory viral infection, has affected more than 10 million individuals worldwide. Common symptoms include fever, dry cough, fatigue and shortness of breath. Some patients show neurological manifestations such as headache, dizziness, cerebrovascular disease, peripheral nerve and muscle symptoms and smell and taste impairment. In previous studies, SARS-CoV-1 and MERS-CoV were found to affect the nervous system. Given the high similarity between SARS-CoV-1 and SARS-CoV-2, effects on the nervous system by SARS-CoV-2 are a possibility. We have outlined the common neurological manifestations in COVID-19 (information are up-to-date as of June 2020) and discussed the possible pathogenetic mechanisms and management options.
DOI : 10.1177/2050312120957925
ISSN: 2050-3121
Cilt: 8
Sınıflandırma :
6
COVID-19: the novel SARS-CoV-2 pandemic
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Revista Peruana de Medicina Experimental y Salud Pública
Yazar(lar) :
Roberto Alfonso Accinelli , Cristian Mingxiong Zhang Xu , Jia-Der Ju Wang , José Miguel Yachachin-Chávez , Jaime Augusto Cáceres-Pizarro , Karla Beatriz Tafur-Bances , Roberto Gabriel Flores-Tejada , Alejandra del Carmen Paiva-Andrade
Yıl :
2020
COVID-19: the novel SARS-CoV-2 pandemic
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Kaydet Alıntıla
During the first weeks of 2020, cases of SARS-CoV-2 began to be reported outside of China, with a rapid increase in cases and deaths worldwide. SARS-CoV-2 is a positive single-stranded RNA virus, encased in a lipid bilayer derived from the host cell membrane and consists of four structural proteins (S, M, E and N), plus a haemagglutinin-sterase. The binding of the S protein to the ECA2 receptor allows the entry of the virus into the host cell and is a potential therapeutic target. 81% of patients develop mild symptoms, 14% have severe symptoms and 5% require intensive care management. Fever is the most frequent symptom, followed by cough and dyspnea. Most patients do not present leukocytosis, but they do present lymphopenia with sputum cultures that do not show other pathogens. In lung biopsies of severe patients, the most noticeable finding is diffuse alveolar damage. Radiologically, ground glass and alveolar patterns are observed; the lesions being predominantly basal, subpleural, and posterior, with a multifocal peripheral distribution, more affecting the right lower lobe. There is a marked inflammatory response, up to the cytokine storm, in which anti-inflammatory treatment with pulse therapy with methylprednisolone would be indicated. Although there are no large-scale studies regarding the use of chloroquine / hydroxychloroquine, due to the global situation, its use has been authorized for its anti-SARS-CoV-2 and anti-inflammatory effect, which can be potentiated with the use of azithromycin.
DOI : 10.17843/rpmesp.2020.372.5411
Anahtar Kelimeler : síndrome respiratorio agudo grave, neumonía viral, infecciones por coronavirus, pandemia
Cilt: 37
Sayı: 2
Sayfa: 302 - 11
Sınıflandırma :
7
Monitoring respiratory infections in covid-19 epidemics
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Dergi Makalesi
Open Access
Kaynak :
Ora Articles
Dergi:
ORA - Oxford University Research Archive
Yayıncı:
ORA - Oxford University Research Archive
Yazar(lar) :
Chan KH , Lee P-W , Chan CY , Lam KBH , Ho P-L
Yıl :
2020
Monitoring respiratory infections in covid-19 epidemics
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8
Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Autoimmunity Reviews
Yayıncı:
Elsevier
Yazar(lar) :
Yehuda Shoenfeld
Yıl :
2020
Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning
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Kaydet Alıntıla
DOI : 10.1016/j.autrev.2020.102538
ISSN: 1568-9972
Sayı: 6
Cilt: 19
Sayfa: 102538
Sınıflandırma :
9
Syncope, Brugada syndrome, and COVID‐19 lung disease
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Arrhythmia
Yazar(lar) :
Giampaolo Pasquetto , Giovanni Battista Conti , Angela Susana , Lucia Anna Leone , Emanuele Bertaglia
Yıl :
2020
Syncope, Brugada syndrome, and COVID‐19 lung disease COVID‐19 lung disease
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Abstract A 52‐year‐old male with no history of familiar sudden death arrived at our Emergency Department after syncope with loss of consciousness occurred during high fever. The thoracic high‐resolution computed tomography demonstrated bilateral multiple ground‐glass opacities. The nose‐pharyngeal swab resulted positive for SARS‐CoV‐2. The 12‐lead ECG presented a “coved‐type” aspect in leads V1 and V2 at the fourth intercostal space and a first degree atrio‐ventricular block. As soon as the temperature went down, the 12‐lead ECG resumed a normal aspect, maintaining a long PR interval.
DOI : 10.1002/joa3.12375
Anahtar Kelimeler : Brugada syndrome, COVIDu201019 lung disease, fever
Cilt: 36
Sayı: 4
Sayfa: 768 - 770
Sınıflandırma :
10
Features of anosmia in COVID-19
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Médecine et Maladies Infectieuses
Yayıncı:
Elsevier
Yazar(lar) :
T. Klopfenstein , N.J. Kadiane-Oussou , L. Toko , P.-Y. Royer , Q. Lepiller , V. Gendrin , S. Zayet
Yıl :
2020
Features of anosmia in COVID-19 Background Medical publications about anosmia with COVID- 19 are scarce. We aimed to describe the prevalence and features of anosmia in COVID- 19 patients. Results Fifty-four of 114 patients (47%) with confirmed COVID- 19 reported anosmia. COVID-19
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Background Medical publications about anosmia with COVID-19 are scarce. We aimed to describe the prevalence and features of anosmia in COVID-19 patients. Methods We retrospectively included COVID-19 patients with anosmia between March 1st and March 17th, 2020. We used SARS-CoV-2 real time PCR in respiratory samples to confirm the cases. Results Fifty-four of 114 patients (47%) with confirmed COVID-19 reported anosmia. Mean age of the 54 patients was 47 (± 16) years; 67% were females and 37% were hospitalised. The median Charlson comorbidity index was 0.70 (± 1.6 [0–7]). Forty-six patients (85%) had dysgeusia and 28% presented with pneumonia. Anosmia began 4.4 (± 1.9 [1–8]) days after infection onset. The mean duration of anosmia was 8.9 (± 6.3 [1–21]) days and 98% of patients recovered within 28 days. Conclusions Anosmia was present in half of our European COVID-19 patients and was often associated with dysgeusia.
DOI : 10.1016/j.medmal.2020.04.006
Anahtar Kelimeler : COVID-19, Anosmia, Dysgeusia
ISSN: 0399-077X
Sayı: 5
Cilt: 50
Sayfa: 436-439
Sınıflandırma :
11
Current regulatory approaches for accessing potential COVID-19 therapies
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Pharmaceutical Policy and Practice
Yazar(lar) :
Vesa Halimi , Armond Daci , Simona Stojanovska , Irina Panovska-Stavridis , Milena Stevanovic , Venko Filipce , Aleksandra Grozdanova
Yıl :
2020
Current regulatory approaches for accessing potential COVID-19 therapies Abstract This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID- 19 potential therapies either COVID-19
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Abstract This commentary aims to elaborate challenges in the regulatory approaches for accessing and investigating COVID-19 potential therapies either with off-label use, compassionate use, emergency use or for clinical trials. Since no therapies have been formally approved and completely effective and safe to date, the best clinical choice is acquired only after consistent and fair communication and collaboration between licensed clinicians, researchers, regulatory authorities, manufacturers and patients.
DOI : 10.1186/s40545-020-00222-6
Anahtar Kelimeler : COVID-19, Regulatory, Clinical studies, Compassionate use
ISSN: 2052-3211
Cilt: 13
Sayı: 1
Sayfa: 1 - 4
Sınıflandırma :
12
Low-Dose Radiotherapy for Late-Stage COVID-19 Pneumonia?
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Dose-Response
Yazar(lar) :
Michael I. Koukourakis
Yıl :
2020
Low-Dose Radiotherapy for Late-Stage COVID-19 Pneumonia? The unimaginable daily death toll of thousands of victims dying from COVID- 19 pneumonia and the marginal therapeutic value of agents tested, brings forward the re-evaluation of the position of radiotherapy in the treatment of late stage lethal COVID-induced respiratory failure. Whether radiotherapy, in conjunction with remdesivir and/or macrolides can reduce the dramatic death rates related to COVID- 19 is an open challenge, under
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Low dose radiotherapy has been used in the pre-antibiotic era for the treatment of all kind of pneumonia, with relative success. The unimaginable daily death toll of thousands of victims dying from COVID-19 pneumonia and the marginal therapeutic value of agents tested, brings forward the re-evaluation of the position of radiotherapy in the treatment of late stage lethal COVID-induced respiratory failure. A sound biological rationale supports this idea. Immunopathology studies show that excessive inflammation and infiltration of the lung parenchyma by immune cells is the cause of death. Mice lacking IFNαβ receptors remain unaffected by the virus. Radiotherapy at doses of 50-200cG may exert an intense anti-inflammatory effect and reduce the burden of inflammatory cells infiltrating the lungs. Whether radiotherapy, in conjunction with remdesivir and/or macrolides can reduce the dramatic death rates related to COVID-19 is an open challenge, under the absence of an alternative solution.
DOI : 10.1177/1559325820951357
ISSN: 1559-3258
Cilt: 18
Sınıflandırma :
13
Safety of an immunomodulator Mycobacterium w in COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Lung India
Yazar(lar) :
Inderpaul Singh Sehgal , Ashish Bhalla , Goverdhan Dutt Puri , Laxmi Narayana Yaddanapudi , Mini Singh , Pankaj Malhotra , Sahajal Dhooria , Vikas Suri , Ritesh Agarwal
Yıl :
2020
Safety of an immunomodulator Mycobacterium w in COVID-19
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Kaydet Alıntıla
DOI : 10.4103/lungindia.lungindia_242_20
Cilt: 37
Sayı: 3
Sayfa: 279 - 281
Sınıflandırma :
14
Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Immunology
Yazar(lar) :
Jun Wang , Jun Wang , Jun Wang , Qian Li , Qian Li , Yongmei Yin , Yingying Zhang , Yingying Cao , Xiaoming Lin , Lihua Huang , Lihua Huang , Daniel Hoffmann , Mengji Lu , Yuanwang Qiu , Yuanwang Qiu , Yuanwang Qiu
Yıl :
2020
Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 Background: Cases of excessive neutrophil counts in the blood in severe coronavirus disease ( COVID- 19) patients have drawn significant attention. It is urgent to clarify the pathogenesis of neutrophils leading to severe pneumonia in COVID- 19.Methods: A retrospective analysis was performed on 55 COVID Transcriptome analysis revealed that neutrophil activation was correlated with 17 neutrophil extracellular trap (NET)-associated genes in COVID- 19 patients COVID-19
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Background: Cases of excessive neutrophil counts in the blood in severe coronavirus disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was also noted on the pathological findings from autopsies. It is urgent to clarify the pathogenesis of neutrophils leading to severe pneumonia in COVID-19.Methods: A retrospective analysis was performed on 55 COVID-19 patients classified as mild (n = 22), moderate (n = 25), and severe (n = 8) according to the Guidelines released by the National Health Commission of China. Trends relating leukocyte counts and lungs examined by chest CT scan were quantified by Bayesian inference. Transcriptional signatures of host immune cells of four COVID19 patients were analyzed by RNA sequencing of lung specimens and BALF.Results: Neutrophilia occurred in 6 of 8 severe patients at 7–19 days after symptom onset, coinciding with lesion progression. Increasing neutrophil counts paralleled lesion CT values (slope: 0.8 and 0.3–1.2), reflecting neutrophilia-induced lung injury in severe patients. Transcriptome analysis revealed that neutrophil activation was correlated with 17 neutrophil extracellular trap (NET)-associated genes in COVID-19 patients, which was related to innate immunity and interacted with T/NK/B cells, as supported by a protein–protein interaction network analysis.Conclusion: Excessive neutrophils and associated NETs could explain the pathogenesis of lung injury in COVID-19 pneumonia.
DOI : 10.3389/fimmu.2020.02063
Anahtar Kelimeler : coronavirus, COVID-19, neutrophil extracellular trap, pneumonia, neutrophilia, lymphopenia
ISSN: 1664-3224
Cilt: 11
Sınıflandırma :
15
COVID-19-associated delayed posthypoxic necrotizing leukoencephalopathy
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of the Neurological Sciences
Yayıncı:
Elsevier
Yazar(lar) :
Alireza Radmanesh , Anna Derman , Koto Ishida
Yıl :
2020
COVID-19-associated delayed posthypoxic necrotizing leukoencephalopathy
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DOI : 10.1016/j.jns.2020.116945
ISSN: 0022-510X
Cilt: 415
Sayfa: 116945
Sınıflandırma :
16
Thromboinflammation in COVID-19 acute lung injury
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Paediatric Respiratory Reviews
Yayıncı:
Elsevier
Yazar(lar) :
William Beau Mitchell
Yıl :
2020
Thromboinflammation in COVID-19 acute lung injury COVID- 19 also presents with a severe coagulopathy with a high rate of venous thromboembiolism. In our experience as a COVID- 19 epicenter, children and young adults do develop both the coagulopathy and the ALI of COVID- 19. This review will discuss COVID- 19 ALI from a hematological perspective with discussion of the distinct aspects of coagulation that are apparent in COVID COVID-19
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Since the initial description in 2019, the novel coronavirus SARS-Cov-2 infection (COVID-19) pandemic has swept the globe. The most severe form of the disease presents with fever and shortness of breath, which rapidly deteriorates to respiratory failure and acute lung injury (ALI). COVID-19 also presents with a severe coagulopathy with a high rate of venous thromboembiolism. In addition, autopsy studies have revealed co-localized thrombosis and inflammation, which is the signature of thromboinflammation, within the pulmonary capillary vasculature. While the majority of published data is on adult patients, there are parallels to pediatric patients. In our experience as a COVID-19 epicenter, children and young adults do develop both the coagulopathy and the ALI of COVID-19. This review will discuss COVID-19 ALI from a hematological perspective with discussion of the distinct aspects of coagulation that are apparent in COVID-19. Current and potential interventions targeting the multiple thromboinflammatory mechanisms will be discussed.
DOI : 10.1016/j.prrv.2020.06.004
Anahtar Kelimeler : COVID-19, Acute lung injury, Thrombosis, Inflammation
ISSN: 1526-0542
Cilt: 35
Sayfa: 20-24
Sınıflandırma :
17
COVID-19 and Cerebral Hemorrhage: Proposed Mechanisms
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Neuroradiology
Yayıncı:
Elsevier
Yazar(lar) :
Mohamad Syafeeq Faeez Md Noh
Yıl :
2020
COVID-19 and Cerebral Hemorrhage: Proposed Mechanisms
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Kaydet Alıntıla
DOI : 10.1016/j.neurad.2020.05.007
ISSN: 0150-9861

Sınıflandırma :
18
Hemorrhagic stroke and anticoagulation in COVID-19
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Stroke and Cerebrovascular Diseases
Yayıncı:
Elsevier
Yazar(lar) :
Siddhant Dogra , Rajan Jain , Meng Cao , Seda Bilaloglu , David Zagzag , Sarah Hochman , Ariane Lewis , Kara Melmed , Katherine Hochman , Leora Horwitz , Steven Galetta , Jeffrey Berger
Yıl :
2020
Hemorrhagic stroke and anticoagulation in COVID-19 Background and Purpose Patients with the Coronavirus Disease of 2019 ( COVID- 19) are at increased risk for thrombotic events and mortality. Methods Patients over the age of 18 with confirmed COVID- 19 and radiographic evidence of ICH were included in this study. Results We identified 33 COVID- 19 positive patients with ICH, mean age 61.6 years (range 37–83 years), 21.2% of whom were female. COVID-19
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Background and Purpose Patients with the Coronavirus Disease of 2019 (COVID-19) are at increased risk for thrombotic events and mortality. Various anticoagulation regimens are now being considered for these patients. Anticoagulation is known to increase the risk for adverse bleeding events, of which intracranial hemorrhage (ICH) is one of the most feared. We present a retrospective study of 33 patients positive for COVID-19 with neuroimaging-documented ICH and examine anticoagulation use in this population. Methods Patients over the age of 18 with confirmed COVID-19 and radiographic evidence of ICH were included in this study. Evidence of hemorrhage was confirmed and categorized by a fellowship trained neuroradiologist. Electronic health records were analyzed for patient information including demographic data, medical history, hospital course, laboratory values, and medications. Results We identified 33 COVID-19 positive patients with ICH, mean age 61.6 years (range 37–83 years), 21.2% of whom were female. Parenchymal hemorrhages with mass effect and herniation occurred in 5 (15.2%) patients, with a 100% mortality rate. Of the remaining 28 patients with ICH, 7 (25%) had punctate hemorrhages, 17 (60.7%) had small- moderate size hemorrhages, and 4 (14.3%) had a large single site of hemorrhage without evidence of herniation. Almost all patients received either therapeutic dose anticoagulation (in 22 [66.7%] patients) or prophylactic dose (in 3 [9.1] patients) prior to ICH discovery. Conclusions Anticoagulation therapy may be considered in patients with COVID-19 though the risk of ICH should be taken into account when developing a treatment regimen.
DOI : 10.1016/j.jstrokecerebrovasdis.2020.104984
Anahtar Kelimeler : COVID-19, Intracranial hemorrhage, Anticoagulation, Hemorrhagic stroke
ISSN: 1052-3057
Sayı: 8
Cilt: 29
Sayfa: 104984
Sınıflandırma :
19
Rethinking high-risk groups in COVID-19
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Multiple Sclerosis and Related Disorders
Yayıncı:
Elsevier
Yazar(lar) :
Anastasia Vishnevetsky , Michael Levy
Yıl :
2020
Rethinking high-risk groups in COVID-19 COVID-19
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Kaydet Alıntıla
DOI : 10.1016/j.msard.2020.102139
Anahtar Kelimeler : Coronavirus, COVID-19, High risk, Immunocompromised, Elderly
ISSN: 2211-0348
Cilt: 42
Sayfa: 102139
Sınıflandırma :
20
Spectrum of neuropsychiatric manifestations in COVID-19
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Brain, Behavior, and Immunity
Yayıncı:
Elsevier
Yazar(lar) :
Krishna Nalleballe , Sanjeeva Reddy Onteddu , Rohan Sharma , Vasuki Dandu , Aliza Brown , Madhu Jasti , Sisira Yadala , Karthika Veerapaneni , Suman Siddamreddy , Akshay Avula , Nidhi Kapoor , Kamran Mudassar , Sukanthi Kovvuru
Yıl :
2020
Spectrum of neuropsychiatric manifestations in COVID-19 Corona Virus Disease 2019 ( COVID- 19) emerged in December 2019 from Wuhan, China. We analyzed COVID- 19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic - 19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations.
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Corona Virus Disease 2019 (COVID-19) emerged in December 2019 from Wuhan, China. It typically presents with mild upper respiratory tract infection symptoms and may have life threatening complications, including acute respiratory distress syndrome, acute stroke, myocardial infarction, kidney failure, shock, and even death. Coronavirus infections are known to have neuroinvasive potential with consequent neuropsychiatric manifestations. We analyzed COVID-19 adult patients in the TriNetX database, which is a global health collaborative clinical research platform collecting real-time electronic medical records data from a network of health care organizations (HCOs) from January 20, 2020 to June 10th, 2020. 40,469 patients were diagnosed with COVID-19 among whom 9086 (22.5%) patients had neuropsychiatric manifestations. The most common neurologic manifestations included headache (3.7%) and sleep disorders (3.4%), Encephalopathy (2.3%), Stroke and transient ischemic attack (TIA) (1.0%) and 0.6% had seizures. Most common psychiatric manifestations included anxiety and other related disorders (4.6%), mood disorders (3.8%), while 0.2% patients had suicidal ideation. Early recognition and prompt management of neuropsychiatric manifestations in these patients have a potential to decrease overall morbidity and mortality.
DOI : 10.1016/j.bbi.2020.06.020
ISSN: 0889-1591
Cilt: 88
Sayfa: 71-74
Sınıflandırma :
21
A cautionary tale of false-negative nasopharyngeal COVID-19 testing
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
IDCases
Yazar(lar) :
Sean S.M. Bullis , Jessica W. Crothers , Shawn Wayne , Andrew J. Hale
Yıl :
2020
A cautionary tale of false-negative nasopharyngeal COVID-19 testing Serial testing for COVID- 19 is indicated in patients with high pretest probability of disease. COVID-19
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Kaydet Alıntıla
There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. We present a case where two nasopharyngeal specimens were negative, followed by a positive sputum sample. Serial testing for COVID-19 is indicated in patients with high pretest probability of disease.
Anahtar Kelimeler : SARS-CoV-2, COVID-19, Nasopharyngeal swab
ISSN: 2214-2509
Cilt: 20
Sayfa: e00791
Sınıflandırma :
22
Defining causality in COVID-19 and neurological disorders
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Dergi Makalesi
Open Access
Kaynak :
Ora Articles
Dergi:
ORA - Oxford University Research Archive
Yayıncı:
ORA - Oxford University Research Archive
Yazar(lar) :
Ellul M , Varatharaj A , Nicholson T , Pollack T , Zandi MS , Manji H , Solomon T , Carson A , Turner MR , Kneen R , Galea I , Pett S , Thomas RH , Michael BD
Yıl :
2020
Defining causality in COVID-19 and neurological disorders
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Sınıflandırma :
23
Neurologic Involvement in COVID-19: Radiologists’ Perspective
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Academic Radiology
Yayıncı:
Elsevier
Yazar(lar) :
Nastaran Khalili , Sara Haseli , Hooman Bahrami-Motlagh , Elham Keshavarz , Neda Khalili , Taraneh Faghihi Langroudi , Arash Khameneh , Morteza Sanei Taheri
Yıl :
2020
Neurologic Involvement in COVID-19: Radiologists’ Perspective
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DOI : 10.1016/j.acra.2020.04.035
ISSN: 1076-6332
Sayı: 7
Cilt: 27
Sayfa: 1051-1053
Sınıflandırma :
24
Nebulized Lidocaine in COVID-19, An Hypothesis
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Medical Hypotheses
Yayıncı:
Elsevier
Yazar(lar) :
Ziad A. Ali , Rif S. El-Mallakh
Yıl :
2020
Nebulized Lidocaine in COVID-19, An Hypothesis Coronavirus Diseases-2019 ( COVID- 19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID- 19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients’ lungs and improving outcomes in COVID- 19 patients COVID-19
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients’ lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
DOI : 10.1016/j.mehy.2020.109947
Anahtar Kelimeler : Lidocaine, COVID-19, SARS-CoV-2, Cytokine-storm, Anti-inflammatories
ISSN: 0306-9877
Cilt: 144
Sayfa: 109947
Sınıflandırma :
25
Ozone Therapy as a Possible Option in COVID-19 Management
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Public Health
Yazar(lar) :
Alessandra Gavazza , Andrea Marchegiani , Giacomo Rossi , Marianno Franzini , Marianno Franzini , Andrea Spaterna , Sara Mangiaterra , Matteo Cerquetella
Yıl :
2020
Ozone Therapy as a Possible Option in COVID-19 Management COVID-19
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.3389/fpubh.2020.00417
Anahtar Kelimeler : COVID-19, ozone, public health, SARS-CoV-2, therapy
ISSN: 2296-2565
Cilt: 8
Sınıflandırma :
26
EEG findings in COVID-19 related encephalopathy
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Clinical Neurophysiology
Yayıncı:
Elsevier
Yazar(lar) :
Elena Pasini , Francesca Bisulli , Lilia Volpi , Irene Minardi , Maria Tappatà , Lorenzo Muccioli , Umberto Pensato , Patrizia Riguzzi , Paolo Tinuper , Roberto Michelucci
Yıl :
2020
EEG findings in COVID-19 related encephalopathy
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DOI : 10.1016/j.clinph.2020.07.003
ISSN: 1388-2457
Sayı: 9
Cilt: 131
Sayfa: 2265-2267
Sınıflandırma :
27
Ivermectin in COVID-19. Argumentun ad ignorantiam?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Revista Clínica Española (English Edition)
Yayıncı:
Elsevier
Yazar(lar) :
Y. Carlosama-Rosero
Yıl :
2020
Ivermectin in COVID-19. Argumentun ad ignorantiam?
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Kaydet Alıntıla
DOI : 10.1016/j.rceng.2020.06.003
ISSN: 2254-8874
Sayı: 7
Cilt: 220
Sayfa: 457-458
Sınıflandırma :
28
Sex‐related differences in COVID‐19 lethality
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
British Journal of Pharmacology
Yazar(lar) :
Claudia Penna , Valentina Mercurio , Carlo G. Tocchetti , Pasquale Pagliaro
Konu :
Pharmacology
Yıl :
2020
Sex‐related differences in COVID‐19 lethality Many countries have been affected by the worldwide outbreak of COVID‐ 19. In Italy and elsewhere, women seem to be less affected than men by severe/fatal COVID‐ 19 infection, regardless of their age.
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Kaydet Alıntıla
Many countries have been affected by the worldwide outbreak of COVID‐19. Among Western countries, Italy has been particularly hit at the beginning of the pandemic, immediately after China. In Italy and elsewhere, women seem to be less affected than men by severe/fatal COVID‐19 infection, regardless of their age. Although women and men are affected differently by this infection, very few studies consider different therapeutic approaches for the two sexes. Understanding the mechanisms underlying these differences may help to find appropriate and sex specific therapies. Here, we consider that other mechanisms are involved to explain this difference, in addition to the protection attributable to oestrogens. Several X‐linked genes (such as ACE2) and Y‐linked genes (SRY and SOX9) may explain sex differences. Cardiovascular comorbidities are among the major enhancers of virus lethality. In addition, the number of sex‐independent, non‐genetic factors that can change susceptibility and mortality is enormous, and many other factors should be considered, including gender and cultural habits in different countries.
DOI : 10.1111/bph.15207
ISSN: 0007-1188

Sınıflandırma :
29
East meets West in COVID-19 therapeutics
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Pharmacological Research
Yayıncı:
Elsevier
Yazar(lar) :
Shanshan Wang , Xian Zeng , Yali Wang , Yufen Zhao , Weiping Chen , Yu Zong Chen
Yıl :
2020
East meets West in COVID-19 therapeutics
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/j.phrs.2020.105008
ISSN: 1043-6618
Cilt: 159
Sayfa: 105008
Sınıflandırma :

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