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COVID-19-associated encephalopathy: Neurological manifestation of COVID-19
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Radiology Case Reports
Yazar(lar) :
Safaa Saeed Al Mazrouei , MBBS , Ghufran Aref Saeed , MBBS , Abeer Ahmed Al Helali , MBBS , Manzoor Ahmed , MBBS
Yıl :
2020
COVID-19-associated encephalopathy: Neurological manifestation of COVID-19 Coronavirus disease 2019 ( COVID- 19) is a viral disease, also known as severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China COVID- 19-associated neurological manifestations have not been widely reported. In this report, we describe a case of encephalopathy in a patient with COVID- 19 infection. Covid-19
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Coronavirus disease 2019 (COVID-19) is a viral disease, also known as severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China, December 2019. Respiratory manifestations from the induced acute lung injury were the most common reported findings. Few cases showed extrapulmonary manifestations. COVID-19-associated neurological manifestations have not been widely reported. In this report, we describe a case of encephalopathy in a patient with COVID-19 infection.
Anahtar Kelimeler : Covid-19, coronavirus, RT-PCR, reverse transcription polymerase chain reaction, central nervous system, Encephalopathy
ISSN: 1930-0433
Cilt: 15
Sayı: 9
Sayfa: 1646 - 1649
Sınıflandırma :
2
Investigating the autoimmunity profiles of Covid-19 patients
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Alfred Kedhammar
Yıl :
2021
Investigating the autoimmunity profiles of Covid-19 patients The clinical severity of Covid- 19 varies greatly between individuals, and all underlying risk factors are not yet well understood. In this project, the interplay between severe Covid- 19 and autoimmunity was investigated in 114 Swedish patients, sampled in April- May 2020 as well as - 19 varierar kraftigt mellan individer och alla underliggande riskfaktorer är ännu inte förstådda. Covid-19 Covid-19
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The clinical severity of Covid-19 varies greatly between individuals, and all underlying risk factors are not yet well understood. Previous studies have shown Covid patients to be enriched with autoantibodies against type I interferons, suggesting autoimmunity may be an underlying factor of susceptibility to severe disease. In this project, the interplay between severe Covid-19 and autoimmunity was investigated in 114 Swedish patients, sampled in April- May 2020 as well as longitudinal re-samplings 4 and 8 months later, using the infrastructure of the Human Protein Atlas and the SciLife lab autoimmunity and serology profiling unit. First, 16 patients with few comorbidities were analyzed for autoantibodies at a near proteome-wide scale using planar microarrays, after which a custom antigen panel was assembled based on observed reactivities and literature studies. The antigen panel was implemented in a 384-plex suspension bead array which was run for all patient samples and a control group. Among the Covid patients, 23 antigens were called as differentially reactive and 8 of them were proposed as relevant to immunoregulation or Covid pathogenesis. The results partially replicated previous findings of autoimmunity directed to type I interferons and offer a list of candidate autoantigens for further inquiries. / Allvarlighetsgraden av sjukdomen Covid-19 varierar kraftigt mellan individer och alla underliggande riskfaktorer är ännu inte förstådda. Tidigare studier har påvisat Covidpatienter som överrepresenterade med autoantikroppar mot typ I interferoner, vilket förespråkar autoimmunitet som en möjlig underliggande riskfaktor till att utveckla allvarlig Covid. I detta projekt användes infrastrukturen av det mänskliga proteinatlasprojektet och enheten för autoimmunitets- och serologiprofilering på SciLife lab för att undersöka samspelet mellan allvarlig Covid-19 och autoimmunitet i 114 st svenska patienter inlagda under april-maj 2020, samt från uppföljningsprover 4 resp. 8 månader senare. Till en början undersöktes 16 patienter med låg grad av samsjukdom för förekomst av autoan- tikroppar mot proteomet i stort med hjälp av mikroarrayer. En panel av antigen sammanställdes därefter baserat på resultaten och litteraturstudier. Panelen implementerades som en 384-plex kulsuspensionsarray vilken kördes för alla patientprover samt en kontrollgrupp. Ibland Covidpatienterna klassades 23 st antigen som överrepresenterade, varav 8 st avsågs relevanta för immunoreglering eller sjukdomsförlopp. Resultaten visades delvis återskapa tidigare fynd av autoimmunitet riktad mot typ I interferoner och erbjuda en lista av potentiella autoantigen för vidare efterforskningar.
Anahtar Kelimeler : Covid-19, SARS-CoV-2, Autoimmunity, Autoantibodies, Cytokines, Covid-19, SARS-CoV-2, Autoimmunitet, Autoantikroppar, Cytokiner
Sınıflandırma :
Viroloji %67
3
Why COVID-19?
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Advanced Journal of Emergency Medicine
Yazar(lar) :
Elnaz Vahidi , Mohammad Jalili
Yıl :
2020
Why COVID-19? Covid- 19 has been estimated to have a case fatality rate of around 3%. In late December 2019, an outbreak of COVID- 19 was reported from Wuhan city, China. Today COVID- 19 has affected more than 212 countries and has made billions of people to be quarantined in their houses.
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COVID-19 is a highly contagious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), an enveloped positive stranded RNA virus and the third member of the family Coronaviridae which has emerged as a zoonotic infection. The predecessor of this new pathogen caused the Severe Acute Respiratory Syndrome (SARS) in 2003 and the Middle East Respiratory Syndrome (MERS) in 2012. Although corona viruses have been known since 1960’s, their familiar species were human pathogens and caused common cold and seasonal flu. SARS-CoV-2 is easily transmitted via respiratory secretions of an infected person, with a reproductive number (the average number of cases to which a single infected person will transmit the virus) of 1.4-2.5. Covid-19 has been estimated to have a case fatality rate of around 3%. As of today, asymptomatic transmission is assumed to be possible during the incubation period, which usually ranges from 2-14 days. The source of infection, animal host, and reservoir are currently unknown. In late December 2019, an outbreak of COVID-19 was reported from Wuhan city, China. The disease soon spread outside China borders and became rapidly prevalent all around the world. The pandemic announcement was officially made by World Health Organization (WHO) on 11 March 2020. Today COVID-19 has affected more than 212 countries and has made billions of people to be quarantined in their houses. Up to now, almost 1500000 confirmed cases of COVID-19 have been reported globally and the death toll has been declared to be 86000. In Iran, we are also facing this unprecedented global public health emergency, with about 65000 confirmed cases and 3993 deaths. This pandemic is beyond an expanding contagious disease and has influenced different features of life. Its enormous social, political, and specifically economic impacts all around the world are undeniable. In low- and middle-income countries this can potentially lead to a huge spike in poverty and collapse. Many vulnerable families have lost their income and access to the essential needs. Education systems have collapsed in many regions. The long-term effect of this global crisis has reduced economic growth even in developed countries. Economic effects of COVID-19 are estimated with dramatic variations. Orlik et al in Bloomberg hypothesized this cost to be $2.7 trillion. The political consequences are even harder to predict but quite significant and devastating, like the heated discussion, criticism and accusation flowing between the leaders of different countries. Since the pandemic is not yet over, the global influence will carry on to happen and make situation even more complicated. While the outbreak is evolving rapidly, health care systems across the world are actively fighting against the new virus. They have encountered many new challenges. Public health measures (such as active case finding, prompt isolation of cases and contacts tracing) to contain the spread of the disease in the society as well as provision of care for the unpredictably high number of people who are infected with the virus have stretched the healthcare system beyond its capacity. At the same time, protecting health care providers’ safety, which often requires provision of sufficient supplies of personal protective equipment, has definitely challenged the system. Societal demand for discovery of a definitive treatment and vaccine has also added to the complexity of the situation that the health care systems are facing. Studies about COVID-19 are increasingly being performed and published; many of them have not yet been fully reviewed and criticized by the academic community. Practitioners often find it difficult to find, appraise and apply the information they need amid the turbulence of their clinical practice. Furthermore, there are still many questions to be answered. The most efficient method for personal protection, methods of viral transmission, most accurate diagnostic approaches, and effective treatment options are yet to be determined. This special issue of the Advanced Journal of Emergency Medicine plans to specifically focus on COVID-19 by gathering the relevant scientific information available. We hope that by publishing high quality papers, this journal can provide its readers with further required information. Appropriate management of patients suffering COVID-19 as well as controlling this pandemic are our ultimate aspirations. We encourage further researches in this field by all scientists and physicians all across the world to be able to eradicate COVID-19 as soon as possible.
DOI : 10.22114/ajem.v0i0.402
ISSN: 2588-400X
Sınıflandırma :
Viroloji %77
4
Fighting COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Brazilian Journal of Biology
Yazar(lar) :
D. M. O. Campos , C. B. S. Oliveira , J. M. A. Andrade , J. I. N. Oliveira
Fighting COVID-19 Abstract The current COVID- 19 pandemic caused by the novel coronavirus (SARS-CoV2) poses a threat to global health owing to its high rate of spread and covid-19
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Abstract The current COVID-19 pandemic caused by the novel coronavirus (SARS-CoV2) poses a threat to global health owing to its high rate of spread and severe forms of respiratory infection. The lack of vaccines and antivirals prevents clinical strategies against the disease, creating an emerging need for the development of safe and effective treatments. Strategies for vaccine development include complete vaccines against viruses, subunits, and nucleic acids, but are still in their early stages. Studies carried out to date on possible SARS-CoV2 drug targets highlight glycoprotein S, Mpro (main protease or protease type 3C), and a member of the transmembrane serine protease II families (TMPRSS2). However, due to the pandemic state, priority is given to marketed drugs. These include chloroquine (CQ), hydroxychloroquine (HCQ), nitazoxanide, remdesivir, Lopinavir/ritonavir (LPV / r), in addition to treatment with convalescent plasma. But, therapeutic specific effects against SARS-CoV2 have not yet been verified. Most of the information obtained about treatment is based on preliminary and limited studies. We conclude that, at this time of emergency, the search for new therapies is more urgent due to the need to save lives. Thus, we point out as interesting targets for future more specific research: glycoprotein S, Mpro, and TMPRSS2.
DOI : 10.1590/1519-6984.238155
Anahtar Kelimeler : virology, sars-cov2, covid-19, infectious diseases
Sınıflandırma :
Biyotıp %100
Viroloji %99
5
COVID-19 solution
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Preventive Medicine
Yazar(lar) :
Roberto Menicagli , Mario Limodio
Yıl :
2020
COVID-19 solution Some CoVs have recently entered humans from infected animals and lastly we have SARS COVID- 19, (CoV), which causes severe acute, often fatal respiratory sars covid-19
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Coronaviruses (CoV) are RNA viruses that cause endemic infections in various species of mammals and avian birds. There are seven known human CoVs, each of which causes respiratory diseases: together account for about one third of common colds. Some CoVs have recently entered humans from infected animals and lastly we have SARS COVID-19, (CoV), which causes severe acute, often fatal respiratory syndromes. The prevalence of CoV, the easy zoonotic transmission and the potential to cause serious respiratory diseases, lead to urgent research to discover the mechanisms of CoV infection. Our study has identified a possible way to eliminate the danger of this virus by analyzing the structures by which it enters the host cell. This study indicates that the neuroaminidase interrupts the infection.
DOI : 10.4103/ijpvm.IJPVM_227_20
Anahtar Kelimeler : neuroaminidase, sars covid-19, sialic acid
Cilt: 11
Sayı: 1
Sayfa: 73 - 73
Sınıflandırma :
Viroloji %95
6
COVID-19: Immunopathogenesis
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
Yazar(lar) :
Deniz MAVİ , Ahmet Çağkan İNKAYA
Yıl :
2020
COVID-19: Immunopathogenesis Coronavirus- 19 disease ( COVID- 19) first described in Wuhan, China at the end of 2019. respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID - 19.
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Coronavirus-19 disease (COVID-19) first described in Wuhan, China at the end of 2019. It spread rapidly all over the world and claimed the lives of over 300,000 people. There is no known effective vaccine and treatment yet. It is impossible to develop vaccines and specific treatment without understanding the pathogenesis of the disease. Experience from severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks may help to elucidate the pathogenesis of COVID-19. Nevertheless, many issues remained obscure regarding the pathogenesis of SARS-CoV-2. Exaggerated immune response leads to respiratory failure and even complications which may culminate in death. Cytokines storm, the complement system, endothelial damage, coagulation cascade, cellular and humoral immunity all play an important role in immune pathogenesis and inflammation. In this review, the relationship between the immune response/host characteristics of SARS-CoV-2 and the severity of the disease, antibody responses, and immune pathogenesis, possible causes of hypercoagulation will be discussed and it’s aimed to provide perspective on the development of effective vaccines and specific treatment.
DOI : 10.5578/flora.69606
Anahtar Kelimeler : sars-cov, sars-cov-2, immunopathogenesis, cytokine storm
ISSN: 1300-932X
Cilt: 25
Sayı: 2
Sayfa: 121 - 131
Sınıflandırma :
Viroloji %74
7
Asymptomatic COVID-19 Infection Management: The Key to Stop COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Clinical and Experimental Investigations
Yazar(lar) :
Rachid Ait Addi , Abdelhafid Benksim , Mohamed Amine , Mohamed Cherkaoui
Yıl :
2020
Asymptomatic COVID-19 Infection Management: The Key to Stop COVID-19 The COVID- 19 disease, emerged in December 2019, has spread rapidly, with new cases confirmed in multiple countries. portion of the population to virus and increase the late diagnosis and thereafter enhance COVID- 19 mortality. Thereafter, it is fundamental to review our COVID- 19 screening approach and enlarge COVID- 19 testing to the general population by using rapid testing appliances COVID-19
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Tam Metin
Kaydet
The COVID-19 disease, emerged in December 2019, has spread rapidly, with new cases confirmed in multiple countries. Many efforts to contain the virus are ongoing, such as containment, individual measures of protection, the authorization of use of some drugs as chloquorine in some countries. Also, it has been known that symptomatic and asymptomatic people whom are infected by COVID-19 have the same contagiousness which expose a far greater portion of the population to virus and increase the late diagnosis and thereafter enhance COVID-19 mortality. Thereafter, it is fundamental to review our COVID-19 screening approach and enlarge COVID-19 testing to the general population by using rapid testing appliances such as rapid SARS-CoV-2 IgG-IgM combined antibody since another appliance more efficient will be performed.
DOI : 10.5799/jcei/7866
Anahtar Kelimeler : COVID-19, pandemic, screening, diagnosis
Cilt: 11
Sayı: 3
Sayfa:
Sınıflandırma :
8
Expression of ACE2 protein and COvid-19 severityThe role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 severity: a comprehensive review
Tez

Tez
Kaynak :
NDTLD Thesis
Yazar(lar) :
Rui Seabra Rodrigues
Yıl :
2021
Expression of ACE2 protein and COvid-19 severityThe role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 severity: a comprehensive review - 19. - 19. 2 (SARS-CoV-2), the virus responsible for the COVID- 19 pandemic.
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A Enzima de Conversão da Angiotensina (ECA2) é uma proteína expressa ao nível da membrana celular, amplamente expressa em tecidos humanos, como o cardíaco e o pulmonar, e já foi provada ser o principal recetor do vírus SARS-CoV-2, responsável pela pandemia COVID-19. A proteína Spike (S) do SARS-CoV-2 liga-se à ECA2 para iniciar o processo de infeção e replicação nas células hospedeiras. A patofisiologia desta proteína na infeção por SARS-CoV-2 é complexa e pode estar associada a diversas condições que cursam com maior severidade da COVID-19, condições estas como a idade, género masculino e comorbilidades associadas aos doentes, nomeadamente, doenças cardiovasculares, doenças respiratórias crónicas, obesidade e diabetes. Neste artigo, apresentamos uma revisão global que visa correlacionar os níveis de expressão da ECA2 em vários órgãos com um pior prognóstico, em pacientes com COVID-19. Neste sentido, níveis significativamente mais elevados de expressão de ECA2 foram observados nos tecidos cardíaco e pulmonar de pacientes com Insuficiência Cardíaca e DPOC, respetivamente. Além disso, um aumento progressivo da expressão da proteína no epitélio respiratório, com a idade, também pode justificar um aumento da severidade da infeção nos idosos. Por último, não parece existir uma associação entre inibidores do sistema renina-angiotensina-aldosterona (RAAS) e uma maior gravidade da infeção por COVID-19. / Angiotensin-Converting Enzyme 2 (ACE2) has been proved to be the main host cell receptor for binding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the COVID-19 pandemic. SARS-CoV-2 Spike (S) protein binds to ACE2 to initiate the process of replication. This enzyme is widely present in human organ tissues, like heart and lung. The pathophysiology of ACE2 in SARS-CoV-2 infection is complex and may be associated with several conditions that are more severe in COVID-19 patients, such as age, male gender, and comorbidities, namely cardiovascular diseases, chronic respiratory diseases, obesity, and diabetes. Here we present a comprehensive review aimed to correlate the levels of expression of the ACE2 in various organs, with a poor outcome in COVID-19 patients. Significantly higher levels of expression of ACE2 were observed in myocardial and lung tissues in heart failure and COPD patients, respectively. An age-dependent increase in SARS2-CoV-2 receptors in the respiratory epithelium may be also responsible for the increased severity of COVID-19 lung disease in elderly people. Although the role of ACE2 is highlighted regarding the damage that can arise upon the SARS-CoV-2 invasion, there was no association observed between renin-angiotensin-aldosterone system (RAAS) inhibitors and the severity of COVID-19.
Anahtar Kelimeler : Ciências da saúde, Health sciences
Sınıflandırma :
Biyotıp %100
Viroloji %100
9
COVID 19: Neuromuscular manifestations
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Annals of Indian Academy of Neurology
Yazar(lar) :
Rajesh Benny , Satish V Khadilkar
Yıl :
2020
COVID 19: Neuromuscular manifestations COVID- 19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. This manuscript studies the available information on the neuromuscular manifestations of COVID- 19. covid-19 neurological manifestations covid-19 neuromuscular manifestations
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COVID-19 pandemic is ongoing and information on the neurological aspects of this viral infection is being gathered. Neuromuscular manifestations have been reported uncommonly in these early stages of the analysis. This manuscript studies the available information on the neuromuscular manifestations of COVID-19.
DOI : 10.4103/aian.AIAN_309_20
Anahtar Kelimeler : covid-19 neurological manifestations, covid-19 neuromuscular manifestations, guillain barre syndrome, myositis
Cilt: 23
Sayı: 7
Sayfa: 40 - 42
Sınıflandırma :
Viroloji %27
10
Tobacco and COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Eurasian Journal of Pulmonology
Yazar(lar) :
Ozlem Sonmez , Zeynep Atam Taşdemir , H Volkan Kara , Sule Akçay
Yıl :
2020
Tobacco and COVID-19 Similar data have been approved found for coronavirus disease-2019 ( COVID- 19) pandemic. adverse effects of tobacco and tobacco products and to raise awareness among the public and to make efforts to smoking on every opportunity during the COVID - 19 pandemic. covid-19
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Tobacco and its products are the well-known causes of premature deaths associated with cancer, cardiovascular disease, and chronic obstructive pulmonary disease, as well as they constitute a significant risk factor that increases the tendency to respiratory system infection and other systemic infections. Active tobacco use and passive smoking increase the risk of infection. Both increase peribronchial and alveolar inflammation and fibrosis and mucosal permeability, cause inadequate mucociliary cleaning, damage to the respiratory tract epithelium resulting in fibrosis, and they adversely affect cellular and humoral immunity. Smoking has been known to increase the risk for viral infections and influenza. Similar data have been approved found for coronavirus disease-2019 (COVID-19) pandemic. Smoking is reported to be associated with the frequency of the disease and its severity of the clinical course. Severe acute respiratory syndrome-coronavirus-2 penetrates the cell using the angiotensin-converting enzyme 2 receptors. Such receptor proteins had been shown to increase in smoker individuals. Also, smoking facilitates penetration of the virus into the cell. The frequency of smoking and the rates of admission to intensive care, mechanical ventilation, and mortality have been also found to be higher was higher in severe cases. The risk for disease progression was found to be 14-fold higher in smokers. Further, the World Health Organization emphasized similar negative effects of hookah and new tobacco products such as electronic cigarettes and heated tobacco products. It is vital to underline the adverse effects of tobacco and tobacco products and to raise awareness among the public and to make efforts to smoking on every opportunity during the COVID-19 pandemic. Public awareness campaigns during the pandemic must always accompanied by the methods and strategies to avoid active and passive smoking.
DOI : 10.4103/ejop.ejop_52_20
Anahtar Kelimeler : covid-19, sars-cov-2, smoking, tobacco use
Cilt: 22
Sayı: 4
Sayfa: 12 - 15
Sınıflandırma :
11
Pathogenesis of COVID-19
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Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Eurasian Journal of Pulmonology
Yazar(lar) :
Evrim Eylem Akpinar
Yıl :
2020
Pathogenesis of COVID-19 The coronavirus disease 2019 ( COVID- 19) is a very contagious infectious disease which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV The aim of this report is to review the immunopathogenesis of COVID- 19 in the light of current literature. covid-19
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The coronavirus disease 2019 (COVID-19) is a very contagious infectious disease which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus is first identified in Wuhan city of China in December 2019 and in a short time dispersed to rest of the World. Animal to human transmission of the virus happened by eating of an infected animal and then the virus is transmitted to healthy persons by close contact. Coronaviruses attach and enter to the host cells by means of the spikes on the cell membrane. The type 2 pneumocytes are the primary target of the virus. The aim of this report is to review the immunopathogenesis of COVID-19 in the light of current literature.
DOI : 10.4103/ejop.ejop_54_20
Anahtar Kelimeler : coronavirus, covid-19, pathogenesis
Cilt: 22
Sayı: 4
Sayfa: 8 - 11
Sınıflandırma :
Viroloji %88
12
Acceptance of COVID-19 Vaccination during the COVID-19 Pandemic in China
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Vaccines
Yazar(lar) :
Jiahao Wang , Rize Jing , Xiaozhen Lai , Haijun Zhang , Yun Lyu , Maria Deloria Knoll , Hai Fang
Yıl :
2020
Acceptance of COVID-19 Vaccination during the COVID-19 Pandemic in China Background: Faced with the coronavirus disease 2019 ( COVID- 19) pandemic, the development of COVID- 19 vaccines has been progressing at an unprecedented of vaccines against COVID- 19 during the pandemic. - 19 vaccination or valuing doctor’s recommendations could increase the probability of accepting COVID- 19 vaccination as soon as possible, while having COVID-19
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Background: Faced with the coronavirus disease 2019 (COVID-19) pandemic, the development of COVID-19 vaccines has been progressing at an unprecedented rate. This study aimed to evaluate the acceptance of COVID-19 vaccination in China and give suggestions for vaccination strategies and immunization programs accordingly. Methods: In March 2020, an anonymous cross-sectional survey was conducted online among Chinese adults. The questionnaire collected socio-demographic characteristics, risk perception, the impact of COVID-19, attitudes, acceptance and attribute preferences of vaccines against COVID-19 during the pandemic. Multivariate logistic regression was performed to identify the influencing factors of vaccination acceptance. Results: Of the 2058 participants surveyed, 1879 (91.3%) stated that they would accept COVID-19 vaccination after the vaccine becomes available, among whom 980 (52.2%) wanted to get vaccinated as soon as possible, while others (47.8%) would delay the vaccination until the vaccine’s safety was confirmed. Participants preferred a routine immunization schedule (49.4%) to emergency vaccination (9.0%) or either of them (41.6%). Logistic regression showed that being male, being married, perceiving a high risk of infection, being vaccinated against influenza in the past season, believing in the efficacy of COVID-19 vaccination or valuing doctor’s recommendations could increase the probability of accepting COVID-19 vaccination as soon as possible, while having confirmed or suspected cases in local areas, valuing vaccination convenience or vaccine price in decision-making could hinder participants from immediate vaccination. Conclusion: During the pandemic period, a strong demand for and high acceptance of COVID-19 vaccination has been shown among the Chinese population, while concerns about vaccine safety may hinder the promotion of vaccine uptake. To expand vaccination coverage, immunization programs should be designed to remove barriers in terms of vaccine price and vaccination convenience, and health education and communication from authoritative sources are important ways to alleviate public concerns about vaccine safety.
DOI : 10.3390/vaccines8030482
Anahtar Kelimeler : SARS-CoV-2, COVID-19, immunization, vaccine acceptance, vaccine preference
ISSN: 2076-393X
Cilt: 8
Sayı: 482
Sayfa: 482
Sınıflandırma :
13
COVID-19 and our DNA
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
The International Journal of Frontier Sciences
Yazar(lar) :
Muhammad Aslamkhan
Yıl :
2020
COVID-19 and our DNA covid-19
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On December 31st 2019, Chinese Health Authorities in Wuhan city of their Hubei province, diagnosed 29 pneumonia cases of unknown etiology and informed WHO (World Health Organization). The unknown virus resembled SARS (severe acute respiratory syndrome), that occurred in China in November 2002, caused by a novel corona virus spilling over from an animal reservoir and transmitted by respiratory droplets. More than 8000 cases and 774 deaths were caused by SARS and circa US$20 billion coasted for its control.
DOI : 10.37978/tijfs.v4i2.206
Anahtar Kelimeler : covid-19, epidemic, epidemiology, genetic susceptibility, genome, pakistan, rna enveloped viruses, wuhan
Cilt: 4
Sayı: 2
Sayfa: 55 - 58
Sınıflandırma :
Viroloji %100
14
ACE2, Metformin, and COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
iScience
Yazar(lar) :
Atul Malhotra , Mark Hepokoski , Karen C. McCowen , John Y-J Shyy
Yıl :
2020
ACE2, Metformin, and COVID-19 Summary: COVID- 19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID- 19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID- 19.
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Summary: COVID-19 is becoming a leading cause of mortality throughout the world, and few effective therapies are currently available. Angiotensin converting enzyme 2 (ACE2) is essential to COVID-19 pathogenesis, as the binding of SARS-CoV-2 spike protein (S protein) is required for viral entry and development of COVID-19. ACE2 regulates the protective arm of the renin-angiotensin-aldosterone system (RAAS) that endows anti-hypertensive and anti-inflammatory effects in the cardiovascular and pulmonary systems. Preclinical data suggest ACE2 might be downregulated after SARS-CoV-2 binding, and treatments that increase ACE2 may prevent cardiopulmonary injury. Development, testing, and mass production of novel ACE2 therapies may take years, whereas more effective treatments for COVID-19 are needed urgently. Metformin is a widely available anti-diabetic agent that has an excellent safety profile, and clinical and preclinical data suggest metformin may offer cardiopulmonary protection in COVID-19 via enhanced ACE2 expression.
Anahtar Kelimeler : Virology, Endocrinology
ISSN: 2589-0042
Cilt: 23
Sayı: 9
Sayfa: 101425
Sınıflandırma :
Biyotıp %100
Viroloji %98
15
SARS-CoV-2(COVID-19)
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
مجلة كلية الطب
Yazar(lar) :
Batool Ali Galib
Yıl :
2020
SARS-CoV-2(COVID-19) viruses to more severe diseases such as Severe Acute Respiratory Syndrome (SARS) during 2002, Middle East Respiratory Syndrome (MERS) during 2012, and the COVID - 19 that started during December 2019 in Wuhan, China.
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Kaydet
Coronaviruses are a large family of viruses which may cause illness in animals or humans. In humans, seven strains of coronaviruses were recognized to cause respiratory infections ranging from the common cold associated with HKU1, NL63, OC43 and 229E viruses to more severe diseases such as Severe Acute Respiratory Syndrome (SARS) during 2002, Middle East Respiratory Syndrome (MERS) during 2012, and the COVID-19 that started during December 2019 in Wuhan, China. This is a review for the current pandemic
Cilt: 61
Sayı: 3,4
Sınıflandırma :
Viroloji %100
16
Covid-19 Pandemic-Insights and Challenges
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
Internet Archive
Yayıncı:
Internet Archive
Yazar(lar) :
Journal of Biomedical Research & Environmental Sciences
Yıl :
2020
Covid-19 Pandemic-Insights and Challenges Coronavirus Disease ( COVID- 19) is associated with respiratory illness that lead to severe pneumonia and Acute Respiratory Distress Syndrome (ARDS). Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), Covid- 19 shows some unique pathogenetic On the basis of the phylogenetic relationship as well as genomic structures, the Covid- 19 belongs to genera Betacoronavirus.
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The 2019 Novel Coronavirus (2019-nCoV) outbreak affected a large number of deaths with millions of confirmed cases worldwide. Coronavirus Disease (COVID-19) is associated with respiratory illness that lead to severe pneumonia and Acute Respiratory Distress Syndrome (ARDS). Although related to the Severe Acute Respiratory Syndrome (SARS) and the Middle East Respiratory Syndrome (MERS), Covid-19 shows some unique pathogenetic, epidemiological and clinical features. On the basis of the phylogenetic relationship as well as genomic structures, the Covid-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have shared similarities, yet differences also in their genomic and phenotypic level that influence the pathogenesis. To gain knowledge regarding the pathophysiology and virulence of the Covid-19 virus, it is absolutely necessary to understand its genetic makeup, transmission, virulence factors, risk factors, diagnosis, clinical presentations, outcome predictions, management of risk factors and ways to control the disease thus providing an insight to the current or future treatment and management protocols. To provide a review of the differences in pathogenesis, epidemiology and clinical features of Covid-19, its transmission and replication dynamics, genome organization, current clinical trials and vaccine development strategies, Immunoinformatics, diagnostics and ways to control the pandemic, inorder to raise an increasing awareness, both to the public and for scientific perspectives.
17
From SARS to COVID-19: What we have learned about children infected with COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Infectious Diseases
Yazar(lar) :
Meng-Yao Zhou , Xiao-Li Xie , Yong-Gang Peng , Meng-Jun Wu , Xiao-Zhi Deng , Ying Wu , Li-Jing Xiong , Li-Hong Shang
Yıl :
2020
From SARS to COVID-19: What we have learned about children infected with COVID-19 There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 ( COVID- 19) - 19. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID- 19 literature. COVID-19
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Kaydet
Introduction: Coronaviruses, both SARS-CoV and SARS-CoV-2, first appeared in China. They have certain biological, epidemiological and pathological similarities. To date, research has shown that their genes exhibit 79% of identical sequences and the receptor-binding domain structure is also very similar. There has been extensive research performed on SARS; however, the understanding of the pathophysiological impact of coronavirus disease 2019 (COVID-19) is still limited. Methods: This review drew upon the lessons learnt from SARS, in terms of epidemiology, clinical characteristics and pathogenesis, to further understand the features of COVID-19. Results: By comparing these two diseases, it found that COVID-19 has quicker and wider transmission, obvious family agglomeration, and higher morbidity and mortality. Newborns, asymptomatic children and normal chest imaging cases emerged in COVID-19 literature. Children starting with gastrointestinal symptoms may progress to severe conditions and newborns whose mothers are infected with COVID-19 could have severe complications. The laboratory test data showed that the percentage of neutrophils and the level of LDH is higher, and the number of CD4+ and CD8+T-cells is decreased in children's COVID-19 cases. Conclusion: Based on these early observations, as pediatricians, this review put forward some thoughts on children's COVID-19 and gave some recommendations to contain the disease.
Anahtar Kelimeler : Coronavirus, COVID-19, SARS-CoV-2, 2019-nCoV, Children
Cilt: 96
Sayfa: 710 - 714
Sınıflandırma :
18
COVID-19: immunopathogenesis and Immunotherapeutics
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Signal Transduction and Targeted Therapy
Yazar(lar) :
Li Yang , Shasha Liu , Jinyan Liu , Zhixin Zhang , Xiaochun Wan , Bo Huang , Youhai Chen , Yi Zhang
Yıl :
2020
COVID-19: immunopathogenesis and Immunotherapeutics Abstract The recent novel coronavirus disease ( COVID- 19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a Therefore, mechanisms underlying immune abnormalities in patients with COVID- 19 must be elucidated to guide clinical management of the disease. strategies against COVID- 19.
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Abstract The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and severe multiple organ dysfunction. Therefore, mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease. Moreover, rational management of the immune responses to SARS-CoV-2, which includes enhancing anti-viral immunity while inhibiting systemic inflammation, may be key to successful treatment. In this review, we discuss the immunopathology of COVID-19, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COVID-19.
DOI : 10.1038/s41392-020-00243-2
ISSN: 2059-3635
Cilt: 5
Sayı: 1
Sayfa: 1 - 8
Sınıflandırma :
Biyotıp %100
Viroloji %37
19
Novel Coronavirus Infection: COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi
Yazar(lar) :
Ergin ÇİFTÇİ , Fevziye ÇOKSÜER
Yıl :
2020
Novel Coronavirus Infection: COVID-19 The most recent coronavirus, SARS-CoV-2, causing COVID- 19 disease was identified in 2019. There is no specific antiviral drug for COVID- 19 infection. The main protection measure is to avoid contact with the person infected with COVID- 19. covid-19
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Tam Metin
Kaydet
Coronaviruses (CoV) are enveloped, single-chain positive RNA viruses constituting a fairly large family. 229E, OC43, NL63 and HKU1 species are common in humans, often causing mild to moderate respiratory infections. On the other hand, new coronaviruses have emerged, causing severe respiratory infection such as “severe acute respiratory syndrome” (SARS) in 2002 and “Middle East respiratory syndrome” (MERS) in 2012. The most recent coronavirus, SARS-CoV-2, causing COVID-19 disease was identified in 2019. While people of all ages are susceptible to COVID-19 infection, those with underlying chronic diseases and elderly age have increased susceptibility. There is no specific antiviral drug for COVID-19 infection. Therefore, treatment strategy is mostly aimed at supportive treatment and prevention of complications. The main protection measure is to avoid contact with the person infected with COVID-19. Following the identification of COVID-19 disease, it exceeded the region where it was located, the number of cases increased gradually, and intercontinental reports were made. COVID-19 is a highly pathogenic respiratory virus threatening global public health today. In order to eradicate the virus, it is necessary to clarify the source of the virus, to develop specific, effective treatments and a safe vaccine. Effective surveillance and appropriate infection control measures are critical to prevent the spread of the virüs.
DOI : 10.5578/flora.202002
Anahtar Kelimeler : coronavirus infections, covid-19, sars-cov-2
ISSN: 1300-932X
Cilt: 25
Sayı: 1
Sayfa: 9 - 18
Sınıflandırma :
Viroloji %75
20
COVID-19: an updated review
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Infekciâ i Immunitet
Yazar(lar) :
F. A. Isihak , M. A. Hamad , N. G. Mustafa
Yıl :
2020
COVID-19: an updated review COVID- 19 is a zoonotic disease that showed higher levels of transmissibility in humans. So, all the world scientists today are in a race against time to find a vaccine or treatment to COVID- 19, which requires a deeper understanding. covid-19
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COVID-19 is a zoonotic disease that showed higher levels of transmissibility in humans. Coronavirus has the largest recognized genome (28–33 kb) of a positive-sense single stranded RNA. The genome composed of 5′-end, the translationable mRNA sequences for the key proteins; replicase, spike, envelop membrane, and nucleocapsid and 3′-end (polyA tail). This highly contagious virus may impair the immune system in the early phase of the disease, hence the symptoms of the disease appear very rapidly. Importantly until now, there is no efficient strategy for containing the disease. So, all the world scientists today are in a race against time to find a vaccine or treatment to COVID-19, which requires a deeper understanding.
DOI : 10.15789/2220-7619-CAU-1443
Anahtar Kelimeler : covid-19, sars-cov-2, vaccination, virus structure, epidemiology, spikes
Cilt: 10
Sayı: 2
Sayfa: 247 - 258
Sınıflandırma :
21
COVID-19: Knowns, Unknowns, and Questions
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
mSphere
Yazar(lar) :
Stuart Weston , Matthew B. Frieman
Yıl :
2020
COVID-19: Knowns, Unknowns, and Questions covid-19
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The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2.
DOI : 10.1128/mSphere.00203-20
Anahtar Kelimeler : covid-19, coronavirus, sars-cov-2
ISSN: 2379-5042
Cilt: 5
Sayı: 2
Sayfa: e00203-20
Sınıflandırma :
Viroloji %71
22
COVID-19 and Neurological Manifestations
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Annals of the National Academy of Medical Sciences (India)
Yazar(lar) :
Neeraj Balaini , Manish Modi
Yıl :
2020
COVID-19 and Neurological Manifestations Coronavirus disease 2019 ( COVID- 19) is a viral illness caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) which has taken the form We therefore reviewed the neurological diseases or complications associated with COIVID- 19 in available literature. covid-19
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Coronavirus disease 2019 (COVID-19) is a viral illness caused by severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) which has taken the form of a pandemic. It mainly presents as fever, cough, shortness of breath involving respiratory system but neurological manifestations are increasingly being recognized worldwide and even virus RNA was demonstrated to be present in cerebrospinal fluid of a patient. SARS-CoV-2 involves both central nervous system and peripheral nervous system. Virus can enter the neural tissue from hematological route or through retrograde transport from nerve endings. Physicians especially neurologists should be aware regarding neurological manifestations as patient can present with these conditions in emergency. We therefore reviewed the neurological diseases or complications associated with COIVID-19 in available literature.
DOI : 10.1055/s-0040-1714153
Anahtar Kelimeler : coronavirus, covid-19, neurologic complications
Sınıflandırma :
Viroloji %72
23
Current strategies against COVID-19
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Chinese Medicine
Yazar(lar) :
Shahid Hussain , Ya-Jia Xie , Dan Li , Shaukat Iqbal Malik , Jin-cai Hou , Elaine Lai-Han Leung , Xing-Xing Fan
Yıl :
2020
Current strategies against COVID-19 Abstract Coronavirus disease ( COVID- 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world This review will be not only helpful for the current situation of COVID- 19, but can also play a major role in such epidemics in the future. COVID-19
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Abstract Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world health organization (WHO) Due to sudden outbreaks, currently, no completely effective vaccine or drug is clinically approved. Several therapeutic strategies can be envisaged to prevent further mortality and morbidity. Based on the past contribution of traditional Chinese medicines (TCM) and immune-based therapies as a treatment option in crucial pathogen outbreaks, we aimed to summarize potential therapeutic strategies that could be helpful to stop further spread of SARS-CoV-2 by effecting its structural components or modulation of immune responses. Several TCM with or without modification could be effective against the structural protein, enzymes, and nucleic acid should be tested from available libraries or to identify their immune-stimulatory activities to enhance several antiviral biological agents for effective elimination of SARS-CoV-2 from the host. TCM is not only effective in the direct inhibition of virus attachment and internalization in a cell but can also prevent their replication and can also help to boost up host immune response. Immune-modulatory effects of TCMs may lead to new medications and can guide us for the scientific validity of drug development. Besides, we also summarized the effective therapies in clinical for controlling inflammation. This review will be not only helpful for the current situation of COVID-19, but can also play a major role in such epidemics in the future.
DOI : 10.1186/s13020-020-00353-7
Anahtar Kelimeler : COVID-19, Therapeutic strategies, Traditional Chinese medicines, Immune-therapy
ISSN: 1749-8546
Cilt: 15
Sayı: 1
Sayfa: 1 - 12
Sınıflandırma :
Viroloji %48
24
COVID-19 remedies
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Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
Nature Biomedical Engineering
Yayıncı:
Springer Nature
Konu :
Biomedicine, general, Biomedical Engineering/Biotechnology
Yıl :
2020
COVID-19 remedies Repurposed drugs, inhibitors of inflammatory cytokines, neutralizing monoclonal antibodies and sera from convalescent patients will help ease the burden of COVID - 19 on healthcare systems.
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Repurposed drugs, inhibitors of inflammatory cytokines, neutralizing monoclonal antibodies and sera from convalescent patients will help ease the burden of COVID-19 on healthcare systems.
DOI : 10.1038/s41551-020-0579-9
ISSN: 2157-846X
Cilt: 4
Sayı: 6
Sayfa: 575-576
Sınıflandırma :
25
The hallmarks of COVID-19 disease.
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
PLoS Pathogens
Yazar(lar) :
Daolin Tang , Paul Comish , Rui Kang
Yıl :
2020
The hallmarks of COVID-19 disease. The clinical features of COVID- 19, such as fever, cough, shortness of breath, and fatigue, are similar to those of many acute respiratory infections. There is currently no specific treatment for COVID- 19, but antiviral therapy combined with supportive care is the main strategy. Here, we summarize recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID- 19 and discuss potential targets
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Although the route for viral transmission remains a mystery, SARS-CoV-2 may have originated in an animal reservoir, likely that of bat. The clinical features of COVID-19, such as fever, cough, shortness of breath, and fatigue, are similar to those of many acute respiratory infections. There is currently no specific treatment for COVID-19, but antiviral therapy combined with supportive care is the main strategy. Here, we summarize recent progress in understanding the epidemiological, virological, and clinical characteristics of COVID-19 and discuss potential targets with existing drugs for the treatment of this emerging zoonotic disease.
DOI : 10.1371/journal.ppat.1008536
Cilt: 16
Sayı: 5
Sayfa: e1008536
Sınıflandırma :
Viroloji %100
26
COVID‐19 diagnostic testing: Technology perspective
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Clinical and Translational Medicine
Yazar(lar) :
Meng Xu , Dan Wang , Hongye Wang , Xiaomei Zhang , Te Liang , Jiayu Dai , Meng Li , Jiahui Zhang , Kai Zhang , Danke Xu , Xiaobo Yu
Yıl :
2020
COVID‐19 diagnostic testing: Technology perspective Abstract The corona virus disease 2019 ( COVID‐ 19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV Controlling the spread of SARS‐CoV‐2 is therefore inherently dependent on identifying and isolating infected individuals, especially since COVID‐ 19 can Here, we provide a comprehensive review of the different primary technologies used to test for COVID‐ 19 infection, discuss the advantages and disadvantages COVID‐19
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Abstract The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). More than 18 million people were infected with a total of 0.7 million deaths in ∼188 countries. Controlling the spread of SARS‐CoV‐2 is therefore inherently dependent on identifying and isolating infected individuals, especially since COVID‐19 can result in little to no symptoms. Here, we provide a comprehensive review of the different primary technologies used to test for COVID‐19 infection, discuss the advantages and disadvantages of each technology, and highlight the studies that have employed them. We also describe technologies that have the potential to accelerate SARS‐CoV‐2 detection in the future, including digital PCR, CRISPR, and microarray. Finally, remaining challenges in COVID‐19 diagnostic testing are discussed, including (a) the lack of universal standards for diagnostic testing; (b) the identification of appropriate sample collection site(s); (c) the difficulty in performing large population screening; and (d) the limited understanding of SARS‐COV‐2 viral invasion, replication, and transmission.
DOI : 10.1002/ctm2.158
Anahtar Kelimeler : COVIDu201019, diagnostic test, nucleic acid, SARSu2010COVu20102, serum
ISSN: 2001-1326
Cilt: 10
Sayı: 4
Sınıflandırma :
27
Current Avenues for COVID-19 Serology
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Annals of the National Academy of Medical Sciences (India)
Yazar(lar) :
Saumya Srivastava , Vidhi Jain , Vijaya Lakshmi Nag , Sanjeev Misra , Kuldeep Singh
Yıl :
2020
Current Avenues for COVID-19 Serology Development of rapid, reliable, and easy diagnostic tests with high-throughput is the need of the hour for laboratories combating the COVID- 19 pandemic Timely diagnosis, effective treatment, and future prevention are key to management of COVID- 19. covid-19 serological tests
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Development of rapid, reliable, and easy diagnostic tests with high-throughput is the need of the hour for laboratories combating the COVID-19 pandemic. While real-time polymerase chain reaction (RT-PCR) is the gold standard for diagnosing active infections, it is expensive and time-consuming. Serological diagnostic assays with a premise to aid rapid contact tracing, immune status determination, and identification of potential convalescent plasma donors hold great promise. Timely diagnosis, effective treatment, and future prevention are key to management of COVID-19.
DOI : 10.1055/s-0040-1713709
Anahtar Kelimeler : rapid diagnostic tests, covid-19 serological tests, convalescent plasma, immune status, antibody test
Cilt: 56
Sayı: 02
Sayfa: 087 - 090
Sınıflandırma :
28
Satellite Images Baidu COVID 19 Manuscript Preprint
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
Internet Archive
Yayıncı:
Internet Archive
Yazar(lar) :
Harvard Medical School (HMS)
Yıl :
2020
Satellite Images Baidu COVID 19 Manuscript Preprint Abstract The global COVID- 19 pandemic was originally linked to a zoonotic spillover event in Wuhan’s Huanan Seafood Market in November or December of 2019 While queries of the respiratory symptom “cough” show seasonal fluctuations coinciding with yearly influenza seasons, “diarrhea” is a more COVID- 19 specific The increase of both signals precede the documented start of the COVID- 19 pandemic in December, highlighting the value of novel digital sources for surveillance
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Citation Nsoesie, Elaine Okanyene, Benjamin Rader, Yiyao L. Barnoon, Lauren Goodwin, and John S. Brownstein. Analysis of hospital traffic and search engine data in Wuhan China indicates early disease activity in the Fall of 2019 (2020). Abstract The global COVID-19 pandemic was originally linked to a zoonotic spillover event in Wuhan’s Huanan Seafood Market in November or December of 2019. However, recent evidence suggests that the virus may have already been circulating at the time of the outbreak. Here we use previously validated data streams - satellite imagery of hospital parking lots and Baidu search queries of disease related terms - to investigate this possibility. We observe an upward trend in hospital traffic and search volume beginning in late Summer and early Fall 2019. While queries of the respiratory symptom “cough” show seasonal fluctuations coinciding with yearly influenza seasons, “diarrhea” is a more COVID-19 specific symptom and only shows an association with the current epidemic. The increase of both signals precede the documented start of the COVID-19 pandemic in December, highlighting the value of novel digital sources for surveillance of emerging pathogens
Sınıflandırma :
29
Fundamental Basis of COVID-19 Pathogenesis
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Serbian Journal of Experimental and Clinical Research
Yazar(lar) :
Bolevich Sergey Brankovich , Litvitsky Peter Frantzevich , Grachev Sergei Vitalievich , Vorobyev Sergey Ivanovich , Orlova Alexandra Sergeevna , Fokina Marina Anatolievna , Novikov Alexei Alekseevich , Bolevich Stephani Sergeevna , Mikhaleva Anastasia Yurievna , Morozova Elena Mihailovna , Kartashova Maria Konstantinovna , Yavlieva Koka Hasbulatovna , Gudanovich Denis Vitalievich , Srejovic Ivan , Jakovljevic Vladimir
Yıl :
2020
Fundamental Basis of COVID-19 Pathogenesis On February 11th, 2020, the World Health Organization assigned the official name of the infection caused by the new coronavirus – COVID- 19. COVID- 19 has affected people from all over the world given that the infection was noted in 200 countries resulting in annunciation of the pandemic situation The initial stage of COVID- 19 infection is the penetration of SARS-CoV-2 into target cells that have angiotensin converting enzyme type II receptors. coronavirus – covid-19
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At the end of 2019, a new coronavirus infection occurred in the People’s Republic of China with an epicentre in the city of Wuhan. On February 11th, 2020, the World Health Organization assigned the official name of the infection caused by the new coronavirus – COVID-19. COVID-19 has affected people from all over the world given that the infection was noted in 200 countries resulting in annunciation of the pandemic situation. Human corona viruses cause mild to moderate respiratory infections. At the end of 2002, a new coronavirus appeared (SARS-CoV), the causal agent of atypical pneumonia, which caused acute respiratory distress syndrome (ARDS). The initial stage of COVID-19 infection is the penetration of SARS-CoV-2 into target cells that have angiotensin converting enzyme type II receptors. The virus enters the body through the respiratory tract and interacts primarily with toll-like receptors (TLRs). The events in SARS-Cov-2 induced infection follow the next scenario: epithelial cells via TLRs recognize and identify SARS-Cov-2, and after that the information is transmitted to the transcriptional NF-κB, which causes expression of the corresponding genes. Activated in this way, the epithelial cells begin to synthesize various biologically active molecules. The results obtained on preclinical material indicate that ROS generation increases and the antioxidant protection decreases, which plays a major role in the pathogenesis of SARS-CoV, as well as in the progression and severity of this respiratory disease.
DOI : 10.2478/sjecr-2020-0029
Anahtar Kelimeler : world health organization, coronavirus u2013 covid-19, respiratory infection, respiratory distress syndrome
Cilt: 21
Sayı: 2
Sayfa: 93 - 111
Sınıflandırma :
Viroloji %72

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