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1
Mechanism of calcium disilicide‐induced calcification of crystalline silicon surfaces in simulated body fluid under zero bias
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Dergi Makalesi
Kaynak 1:
JSTOR
Kaynak 2:
JSTOR
Kaynak 3:
JSTOR
Kaynak 4:
JSTOR
Kaynak 5:
JSTOR
Dergi:
Journal of Biomedical Materials Research Part A
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Vladimir V. Seregin , Jeffery L. Coffer
Yıl :
2008
Journal of Biomedical Materials Research Part A
Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1002/jbm.a.31691
Cilt: 87A
Sayı: 1
Sayfa: 15-24
Yayın Tarihi: 2008-10-01
2
Mechanism of calcium disilicide‐induced calcification of crystalline silicon surfaces in simulated body fluid under zero bias
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Journal of Biomedical Materials Research Part A
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Vladimir V. Seregin , Jeffery L. Coffer
Yıl :
2008
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1002/jbm.a.31691
Cilt: 87A
Sayı: 1
Sayfa: 15-24
Yayın Tarihi: 2008-10-01
3
Effect of cobalt ions on the interaction between macrophages and titanium
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Mattias Pettersson , Jean Pettersson , Margareta Molin Thorén , Anders Johansson
Yıl :
2018
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
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Kaydet Alıntıla
Inflammation and bone reduction around dental implants are described as peri‐implantitis and can be caused by an inflammatory response against bacterial products and toxins. Titanium (Ti) forms aggregates with serum proteins, which activate and cause release of the cytokine interleukin (IL‐1β) from human macrophages. It was hypothesized that cobalt (Co) ions can interact in the formation of pro‐inflammatory aggregates, formed by titanium. To test this hypothesis, we differentiated THP‐1 cells into macrophages and exposed them to Ti ions alone or in combination with Co ions to investigate if IL‐1β release and cytotoxicity were affected. We also investigated aggregate formation, cell uptake and human biopsies with inductively coupled plasma atomic emission spectroscopy and electron microscopy. Co at a concentration of 100 µM neutralized the IL‐1β release from human macrophages and affected the aggregate formation. The aggregates formed by Ti could be detected in the cytosol of macrophages. In the presence of Co, the Ti‐induced aggregates were located in the cytosol of the cultured macrophages, but outside the lysosomal structures. It is concluded that Co can neutralize the Ti‐induced activation and release of active IL‐1β from human macrophages in vitro. Also, serum proteins are needed for the formation of metal‐protein aggregates in cell medium. Furthermore, the structures of the aggregates as well as the localisation after cellular uptake differ if Co is present in a Ti solution. Phagocytized aggregates with a similar appearance seen in vitro with Ti present, were also visible in a sample from human peri‐implant tissue. © 2018 The Authors Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A:2518–2530, 2018.
DOI : 10.1002/jbm.a.36447
ISSN: 1549-3296
Sayı: 9
Cilt: 106
Sayfa: 2518-2530
4
Cutaneous and inflammatory response to long-term percutaneous implants of sphere-templated porous/solid poly(HEMA) and silicone in mice
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Philip Fleckman , Marcia Usui , Ge Zhao , Robert Underwood , Max Maginness , Andrew Marshall , Christine Glaister , Buddy Ratner , John Olerud
Yıl :
2012
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
DOI : 10.1002/jbm.a.34012
ISSN: 1549-3296
Sayı: 5
Cilt: 100A
Sayfa: 1256-1268
5
Effects of freezing/thawing on the mechanical properties of decellularized lungs
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Paula N. Nonaka , Noelia Campillo , Juan J. Uriarte , Elena Garreta , Esther Melo , Luis V. F. de Oliveira , Daniel Navajas , Ramon Farré
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2013
Journal of Biomedical Materials Research Part A
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Lung bioengineering based on decellularized organ scaffolds is a potential alternative for transplantation. Freezing/thawing, a usual procedure in organ decellularization and storage could modify the mechanical properties of the lung scaffold and reduce the performance of the bioengineered lung when subjected to the physiological inflation‐deflation breathing cycles. The aim of this study was to determine the effects of repeated freezing/thawing on the mechanical properties of decellularized lungs in the physiological pressure–volume regime associated with normal ventilation. Fifteen mice lungs (C57BL/6) were decellularized using a conventional protocol not involving organ freezing and based on sodium dodecyl sulfate detergent. Subsequently, the mechanical properties of the acellular lungs were measured before and after subjecting them to three consecutive cycles of freezing/thawing. The resistance (RL) and elastance (EL) of the decellularized lungs were computed by linear regression fitting of the recorded signals (tracheal pressure, flow, and volume) during mechanical ventilation. RL was not significantly modified by freezing‐thawing: from 0.88 ± 0.37 to 0.90 ± 0.38 cmH2O·s·mL−1 (mean ± SE). EL slightly increased from 64.4 ± 11.1 to 73.0 ± 16.3 cmH2O·mL−1 after the three freeze‐thaw cycles (p = 0.0013). In conclusion, the freezing/thawing process that is commonly used for both organ decellularization and storage induces only minor changes in the ventilation mechanical properties of the organ scaffold. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 413–419, 2014.
DOI : 10.1002/jbm.a.34708
ISSN: 1549-3296
Sayı: 2
Cilt: 102
Sayfa: 413-419
6
0
Dergi Sayısı

Dergi Sayısı
Kaynak 1:
Wiley Online Library
Kaynak 2:
Wiley Online Library
Kaynak 3:
Wiley Online Library
Kaynak 4:
Wiley Online Library
Kaynak 5:
Wiley Online Library
Kaynak 6:
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2018
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
DOI : 10.1002/jbm.a.v106.6
ISSN: 1549-3296
Sayı: 6
Cilt: 106

7
The bone formationin vitro and mandibular defect repair using PLGA porous scaffolds
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Tianbin Ren , Jie Ren , Xiaozhen Jia , Kefeng Pan
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2005
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
DOI : 10.1002/jbm.a.30324
ISSN: 1549-3296
Sayı: 4
Cilt: 74A
Sayfa: 562-569
8
Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Masoud Dadras Chomachayi , Atefeh Solouk , Somaye Akbari , Davoud Sadeghi , Fereshteh Mirahmadi , Hamid Mirzadeh
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2018
Journal of Biomedical Materials Research Part A
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In this study, a nanofibrous electrospun substrate based on the silk fibroin (SF) and gelatin (GT) polymers were prepared and evaluated. The SF/GT blended solutions were prepared with various ratios of GT in formic acid and electrospun to obtain bead‐free fibers. Results showed that addition of GT to SF increased nanofiber's diameter, bulk hydrophilicity, surface wettability, mass loss percentage, but decreased Young's modulus, tensile strength, and porosity of the SF/GT mats. According to the obtained results, the mat containing 10% of GT was selected as the optimized mat for further studies and loaded with thyme essential oil (TEO) and doxycycline monohydrate (DCMH) as the antibacterial agents. Release studies showed a burst release of TEO from the mat within the first 3 h, while the DCMH had a sustained release during 48 h. In comparison to the TEO‐loaded mat, the DCMH‐loaded one showed larger inhibition zones against Staphylococcus aureus and Klebsiella pneumoniae bacteria. Meanwhile, cellular studies using mouse fibroblast L929 cells showed excellent cell‐compatibility of TEO‐ and DCMH‐loaded mats. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1092–1103, 2018.
DOI : 10.1002/jbm.a.36303
ISSN: 1549-3296
Sayı: 4
Cilt: 106
Sayfa: 1092-1103
9
Biomimetic control of vascular smooth muscle cell morphology and phenotype for functional tissue-engineered small-diameter blood vessels
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Mary B. Chan-Park , Jin Ye Shen , Ye Cao , Yun Xiong , Yunxiao Liu , Shahrzad Rayatpisheh , Gavin Chun-Wei Kang , Howard P. Greisler
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2009
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
Small‐diameter blood vessel substitutes are urgently needed for patients requiring replacements of their coronary and below‐the‐knee vessels and for better arteriovenous dialysis shunts. Circulatory diseases, especially those arising from atherosclerosis, are the predominant cause of mortality and morbidity in the developed world. Current therapies include the use of autologous vessels or synthetic materials as vessel replacements. The limited availability of healthy vessels for use as bypass grafts and the failure of purely synthetic materials in small‐diameter sites necessitate the development of a biological substitute. Tissue engineering is such an approach and has achieved promising results, but reconstruction of a functional vascular tunica media, with circumferentially oriented contractile smooth muscle cells (SMCs) and extracellular matrix, appropriate mechanical properties, and vasoactivity has yet to be demonstrated. This review focuses on strategies to effect the switch of SMC phenotype from synthetic to contractile, which is regarded as crucial for the engineering of a functional vascular media. The synthetic SMC phenotype is desired initially for cell proliferation and tissue remodeling, but the contractile phenotype is then necessary for sufficient vasoactivity and inhibition of neointima formation. The factors governing the switch to a more contractile phenotype with in vitro culture are reviewed. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
DOI : 10.1002/jbm.a.32318
ISSN: 1549-3296
Sayı: 4
Cilt: 88A
Sayfa: 1104-1121
10
A novel scaffold based on formation and agglomeration of PCL microbeads by freeze-drying
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
I. Gerçek , R. S. Tıǧlı , M. Gümüşderelioǧlu
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2008
Journal of Biomedical Materials Research Part A
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Polycaprolactone (PCL) scaffolds were prepared by freeze‐drying of polymer solutions in tetrahydrofuran. Effects of the polymer composition, which is 10 and 20% (w/v), on the scaffold properties for example, morphology, porosity, mechanical stability, degradability, and so forth were investigated by using suitable methods. Scanning electron microscopy photographs clearly showed the presence of a porous, three‐dimensional structure including agglomerated PCL microspheres. Porosity analysis demonstrated that 10 and 20% (w/v) scaffolds have 95.9% and 74.4% porosity, respectively. The microspheres have very narrow size distribution and their diameters increase from 50–70 μm to 90–100 μm with increasing PCL content from 10 to 20% (w/v). The microspheres were highly connected with each other and the scaffolds have superior mechanical properties when compared with the traditional PCL scaffolds. Cell culture experiments showed that periodontal ligament cells (PDL) were able to attach and proliferate on the 20% PCL scaffold. The results demonstrated that this novel PCL structure will be a potential tissue engineering scaffold with its superior properties and simple preparation procedure. © 2007 Wiley Periodicals, Inc. JBiomed Mater Res, 2008
DOI : 10.1002/jbm.a.31723
ISSN: 1549-3296
Sayı: 4
Cilt: 86A
Sayfa: 1012-1022
11
Vasculature reconstruction of decellularized liver scaffolds via gelatin-based re-endothelialization
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Fanwei Meng , Falah Almohanna , Abdullah Altuhami , Abdallah M. Assiri , Dieter Broering
Yıl :
2018
Journal of Biomedical Materials Research Part A
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Decellularized liver scaffolds based liver engineering is a promising approach toward developing functional liver surrogates. However, a major obstacle to long‐term transplantation is the hemocompatibility of the bioengineered liver surrogates. One approach to improve the hemocompatibility of engineered liver surrogates is re‐endothelialization. In the current study, immortalized endothelial cells were perfused for re‐endothelialization of decellularized rat liver scaffolds. When compared to the media‐based perfusion approach, gelatin hydrogels‐based perfusion significantly increased the number of cells that were retained in the decellularized liver scaffolds and the vascular lumen coverage ratio. Endothelial cells were lining along the vasculatures of the decellularized liver scaffolds and actively proliferating. Re‐endothelialization improved the blood retention ability of the liver scaffold vasculatures. Doppler ultrasound detected active blood flows within the re‐endothelialized liver scaffold transplants 8 days post‐transplantation. Our results strengthened the feasibility of developing bioengineered liver surrogates utilizing decellularized liver scaffolds. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 392–402, 2019.
DOI : 10.1002/jbm.a.36551
ISSN: 1549-3296
Sayı: 2
Cilt: 107
Sayfa: 392-402
12
Gelatin nonwovens‐based epithelial morphogenesis involves a signaling axis comprising EGF‐receptor, MAP kinases ERK 1/2, and β1 integrin
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Nicole Jedrusik , Thorsten Steinberg , Ayman Husari , Lukas Volk , Xiaoling Wang , Günter Finkenzeller , Sandra Strassburg , Pascal Tomakidi
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2018
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
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Kaydet Alıntıla
In biomaterials research, biomechanics which support tissue regeneration steadily gains of importance. Hence, we have previously shown that gelatin‐based electrospun nonwoven mats (NWMs) with a distinct modulus of elasticity (3.2 kPa) promotes epithelial morphogenesis. Since molecular mechanisms of this morphogenesis are still unknown, the present study aims at identifying molecules, involved herein. Epithelia established on the NMWs showed persistence of the activated state of the epidermal growth factor receptor (EGF‐R), phosphorylated at the src‐specific tyrosine 845 (EGF‐RT845) throughout the observation period of 10 days. To elucidate whether the observed morphogenesis mechanistically involves EGF‐R signaling, we inhibited EGF‐R, by employing the EGF‐RT845 specific inhibitor Gefitinib (IRESSA®). Gefitinib administration yielded a reduced expression of the β1 integrin subunit, a well‐known cell–matrix interaction receptor, concomitant with downregulation of p42/44 ERK1/2 MAP‐kinase activity. To elucidate whether the observed downregulation of β1 is EGF‐RT845‐dependent or emerging from ERK1/2 signaling, we exposed epithelia, grown on the NWMs, with the ERK1/2‐directed inhibitor U0126. In the absence of Gefitinib, inhibition of p42/44 MAP‐kinase activity resulted in decreased β1 integrin protein levels, thus indicating that β1 expression is dependent on ERK1/2 and not EGF‐RT845. Our results showed the first time that an EGF‐R‐β1 integrin‐signaling axis, including ERK1/2, promotes NWM‐elasticity‐based epithelial morphogenesis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 663–677, 2019.
DOI : 10.1002/jbm.a.36585
ISSN: 1549-3296

13
Role of HA and BG in engineering poly( ε ‐caprolactone) porous scaffolds for accelerating cranial bone regeneration
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Huau2010Mo Yin , Xiang Li , Peng Wang , Yue Ren , Wei Liu , Jiau2010Zhuang Xu , Jiu2010Hua Li , Zhongu2010Ming Li
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2018
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Effects of varied bioactive fillers on the biological behavior of porous polymer/inorganic composite scaffolds are lack of comprehensive comparison and remain elusive. Moreover, composite scaffolds with high porosity suffer from inferior mechanical performance. Herein, high‐pressure molding and salt leaching were employed to prepare poly(ε‐caprolactone) (PCL) composite porous scaffolds loaded with hydroxyapatite (HA) and bioactive glass (BG), respectively. Structural analysis indicated all the porous scaffolds presented interconnected open‐pore structure with the porosity of ~87% and pore size of ~180 μm, hinging on the amounts and size of porogen. Compared to PCL/HA scaffolds, PCL/BG scaffolds showed ~2.3‐fold augment in the water absorption. Attributing to the compact framework, the PCL/HA and PCL/BG porous scaffolds exhibited outstanding compressive modulus, which was notably higher than other PCL composite porous scaffolds reported in literatures. Cells culture results demonstrated that PCL/BG scaffolds displayed higher expression of osteogenic differentiation than PCL and PCL/HA scaffolds. Furthermore, in vivo results showed that more mature bone was formed within PCL/BG scaffolds than PCL/HA scaffolds, manifesting that the introduction of BG accelerated cranial bone regeneration to obtain complete bone healing within a short time. Therefore, these data indicate that PCL/BG scaffolds are more competitive for bone tissue engineering application. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 654–662, 2019.
DOI : 10.1002/jbm.a.36584
ISSN: 1549-3296

14
Evaluation of the skin sensitizing potential of biodegradable magnesium alloys
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Frank Witte , Inken Abeln , Elinor Switzer , Volker Kaese , Andrea Meyer-Lindenberg , Henning Windhagen
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2008
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
Corroding metals made of magnesium alloys represent a new class of degradable implants for musculoskeletal surgery. These implants may be associated with skin sensitizing reactions because of the release of metal ions. This study was conducted to compare the sensitizing potential of four different magnesium alloys (AZ31, AZ91, WE43, and LAE442) to current implant materials such as titanium (TiAl6V4) and a degradable polymer (SR‐PLA96). Solutions and solid chips of these materials were prepared and tested in 156 guinea pigs according to the Magnusson–Kligman test. A standard allergen (hydroxy‐cinnamon‐aldehyde) causing allergic erythema was used as positive control and a standard irritant (sodium‐lauryl‐sulfate) causing local skin irritation for less than 24 h was used as negative control. All erythema were graded immediately and 24 h after patch removal by three independent observers. Histomorphological analyses were performed on skin biopsies taken 24 h after patch removal. We found that initial erythema in animals treated with solid chips diminished within 24 h and were caused by local skin irritation. Local skin irritation was also determined in erythema remaining for 24 h after patch removal in animals treated with dissolved test materials. No allergenic reactions according to the histomorphological criteria were observed in skin biopsies. We conclude that no skin sensitizing potential were detected for standard materials as well as for all tested magnesium alloys by the used methods. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
DOI : 10.1002/jbm.a.31713
ISSN: 1549-3296
Sayı: 4
Cilt: 86A
Sayfa: 1041-1047
15
Biological effects of calcium sulfate as a bone graft substitute in ovine metaphyseal defects
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Christopher L. Peters , Jerod L. Hines , Kent N. Bachus , Marcis A. Craig , Roy D. Bloebaum
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2006
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
Calcium sulfate has been used as a bone graft substitute in many fields, from dentistry to orthopedics. However, the results of many studies have yielded inconclusive results. In the present study, a sheep model was used with tibial and femoral metaphyseal defects to determine whether calcium sulfate was as effective as autograft and allograft in promoting new bone formation in a critical size defect. Medical‐grade calcium sulfate pellets, autograft bone, allograft bone, or nothing was used to fill the metaphyseal defects. The sheep were allowed to heal for 12 weeks. Sagittal sections from the bones were analyzed with high‐resolution contact radiographs, backscattered electron microscopy, and light microscopy. The volume fractions of bone within the defect perimeter were determined, and the histologic quality of the bone was observed. The volume fraction of new bone in the autograft, calcium sulfate, and allograft were not statistically different, but all were significantly different than the untreated control. The majority of the calcium sulfate had been resorbed at 12 weeks, and the histologic quality of the bone appeared similar to the autograft‐treated bone. Calcium sulfate appears to be a useful biocompatible bone graft substitute that yields results similar to autograft bone in sheep metaphyseal defects. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
DOI : 10.1002/jbm.a.30569
ISSN: 1549-3296
Sayı: 3
Cilt: 76A
Sayfa: 456-462
16
Reinforcement of tendon attachment to bioactive porous titanium by BMP-2-induced ectopic bone formation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Kazutaka So , Mitsuru Takemoto , Shunsuke Fujibayashi , Masashi Neo , Tadashi Kokubo , Takashi Nakamura
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2009
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
Achieving a firm attachment between a tendon and a metal remains a major challenge in orthopedic surgery. In this study, we developed a simple model for evaluating the strength of this attachment using bioactive porous titanium, and confirmed whether bone morphogenic protein‐2 (BMP‐2) can be a help in achieving a firm attachment by ectopic bone formation. Rectangular plate‐shaped implants were soak‐loaded with BMP‐2 (B+ group) and were implanted within the patellar tendon of a rabbit. Implants without BMP‐2 (B− group) were used as controls, and they were harvested at 4 and 8 weeks postoperation for mechanical tests and for histological and histomorphometric study. The pull‐out failure load of the B+ group was significantly higher than that of the B− group and new bone was more prevalent within the pores and around the implants in the B+ group than in the B− group. The model used in this study was feasible for evaluating the tendon–metal attachment, and a combination of bioactive porous titanium and BMP‐2 was found to attach firmly to the tendon. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
DOI : 10.1002/jbm.a.32640
ISSN: 1549-3296
Cilt: 9999A
Sayfa: NA-NA
17
Biocompatibility and surface structure of chemically modified immunoisolating alginate‐PLL capsules
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
C. M. Bünger , C. Gerlach , T. Freier , K. P. Schmitz , M. Pilz , C. Werner , L. Jonas , W. Schareck , U. T. Hopt , P. de Vos
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2003
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
Grafting of encapsulated living cells has the potential to cure a wide variety of diseases. Large‐scale application of the technique, however, is hampered by insufficient biocompatibility of the capsules. A major factor in the biocompatibility of capsules is inadequate covering of the inflammatory poly‐L‐lysine (PLL) on the capsules' surface. In the present study, we investigate whether tissue responses against alginate‐PLL capsules can be reduced by crosslinking the surface of the capsules with heparin or polyacrylic acid. Our transplant study in rats shows a tissue response composed of fibroblasts and macrophages on alginate‐PLL‐alginate and alginate‐PLL‐heparin capsules that was completely absent on alginate‐PLL‐polyacrylic acid capsules. Atomic force microscopy analyses of the capsules demonstrates that the improved biocompatibility of alginate‐PLL‐capsules by polyacrylic acid coating should not only be explained by a more adequate binding of PLL but also by the induction of a smoother surface. This study shows for the first time that biologic responses against capsules can be successfully deleted by chemically crosslinking biocompatible molecules on the surface of alginate‐PLL capsules. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 1219–1227, 2003
DOI : 10.1002/jbm.a.10094
ISSN: 1549-3296
Sayı: 4
Cilt: 67A
Sayfa: 1219-1227
18
Competitive plasma protein adsorption onto fluorinated polyimide surfaces
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
H. Kawakami , M. Kanno , S. Nagaoka , S. Kubota
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2003
Journal of Biomedical Materials Research Part A
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Kaydet Alıntıla
A series of fluorinated polyimides cured at different temperatures was prepared, and plasma protein adsorption and platelet adhesion onto the polyimide films were evaluated in vitro using scanning electron microscopy, a micro‐bicinchoninic acid protein assay, and a gold–colloid‐labeled immunoassay. In particular, we focused on competitive plasma protein adsorption onto polyimide film because elucidation of the competitive adsorption mechanism is needed for a good understanding of in vivo biocompatibility of polyimide. Interestingly, the trend of IgG adsorption onto the polyimide surface measured in human plasma was completely contrary to that observed with IgG dissolved in PBS, and the adsorption increased with an increase in the curing temperature. We propose that the human plasma Fc region in IgG might selectively adsorb onto polyimide film cured at high temperatures because of competitive plasma protein adsorption to the surface. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 1393–1400, 2003
DOI : 10.1002/jbm.a.20052
ISSN: 1549-3296
Sayı: 4
Cilt: 67A
Sayfa: 1393-1400
19
Robotic deposition and in vitro characterization of 3D gelatin−bioactive glass hybrid scaffolds for biomedical applications
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Chunxia Gao , Mohamed N. Rahaman , Qiang Gao , Akira Teramoto , Koji Abe
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2012
Journal of Biomedical Materials Research Part A
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The development of inorganic−organic hybrid scaffolds with controllable degradation and bioactive properties is receiving considerable interest for bone and tissue regeneration. The objective of this study was to create hybrid scaffolds of gelatin and bioactive glass (BG) with a controlled, three‐dimensional (3D) architecture by a combined sol−gel and robotic deposition (robocasting) method and evaluate their mechanical response, bioactivity, and response to cells in vitro. Inks for robotic deposition of the scaffolds were prepared by dissolving gelatin in a sol−gel precursor solution of the bioactive glass (70SiO2−25CaO−5P2O5; mol%) and aging the solution to form a gel with the requisite viscosity. After drying and crosslinking, the gelatin−BG scaffolds, with a grid‐like architecture (filament diameter ∼350 µm; pore width ∼550 µm), showed an elasto−plastic response, with a compressive strength of 5.1 ± 0.6 MPa, in the range of values for human trabecular bone (2−12 MPa). When immersed in phosphate‐buffered saline, the crosslinked scaffolds rapidly absorbed water (∼440% of its dry weight after 2 h) and showed an elastic response at deformations up to ∼60%. Immersion of the scaffolds in a simulated body fluid resulted in the formation of a hydroxyapatite‐like surface layer within 5 days, indicating their bioactivity in vitro. The scaffolds supported the proliferation, alkaline phosphatase activity, and mineralization of osteogenic MC3T3‐E1 cells in vitro, showing their biocompatibility. Altogether, the results indicate that these gelatin−BG hybrid scaffolds with a controlled, 3D architecture of inter‐connected pores have potential for use as implants for bone regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
DOI : 10.1002/jbm.a.34496
ISSN: 1549-3296
Sayı: 7
Cilt: 101A
Sayfa: 2027-2037
20
Synergistic effect of sustained release of growth factors and dynamic culture on osteoblastic differentiation of mesenchymal stem cells
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Giovanna Della Porta , Bao-Ngoc B. Nguyen , R. Campardelli , Ernesto Reverchon , John P. Fisher
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2014
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
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Microparticles have been utilized as delivery vehicles of soluble factors to modify cellular behavior and therefore enhance tissue engineering regeneration. When incorporated into three‐dimensional systems, microparticles can provide geometrical and temporal controlled release of bioactive agents, such as growth factors (GFs) to surrounding cells. This study investigates the effect of GFs release from biopolymer microparticles on osteoblastic differentiation of human mesenchymal stem cells (hMSCs) encapsulated in calcium (Ca)‐alginate scaffolds while cultured in a tubular perfusion system bioreactor system. Empirical and deterministic models were used to demonstrate that poly(d,l‐lactic‐co‐glycolic acid)‐encapsulated GFs would result in a delayed release profile compared to GFs encapsulated into scaffolds directly. We hypothesized that the dual delivery of human bone‐morphogenetic protein 2 (hBMP2) and human vascular endothelial growth factor to cells in dynamic culture would provide molecular and physical cues to promote differentiation. Results indicated that the exposures of hBMP2 and dynamic flow are sufficient in enhancing the osteoblastic differentiation pathway compared to no GF addition and static culture. The GF delivery system in a dynamic flow environment resulted in a synergistic effect on osteoblastic differentiation of hMSCs. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2161–2171, 2015.
DOI : 10.1002/jbm.a.35354
ISSN: 1549-3296
Sayı: 6
Cilt: 103
Sayfa: 2161-2171
21
Antibacterial properties and corrosion resistance of Cu and Ag/Cu porous materials
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Biomedical Materials Research Part A
Yazar(lar) :
Hemin Jing , Zhiming Yu , Li Li
Konu :
Metals and Alloys, Biomaterials, Ceramics and Composites, Biomedical Engineering
Yıl :
2008
Journal of Biomedical Materials Research Part A
Yayıncı Web Sitesi
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The porous materials of Cu and Ag/Cu were successfully prepared by the electrodeposition on a precursor of conventional polyamide foam. The microstructure of the porous materials was observed by scanning electron microscope. Their porosity and specific surface area were measured. The inhibition effect of Cu porous materials against E. coli was also investigated. The broad‐spectrum of antibiosis of the Cu and Ag/Cu porous materials were characterized. The corrosion resistance of Cu, Ag/Cu coatings was also compared. The shape and size of pores are uniform in three directions for the porous materials. Their porosity may reach above 95% and specific surface area is beyond 12.8 m2/m3. The antibacterial test results show that the Cu porous materials not only exhibited high antibacterial effect and good broad‐spectrum antibacterial properties, but also excellent persistent antibacterial effects; the antibacterial effects, and broad‐spectrum of antibiosis were greatly improved through the deposition of a thin Ag coating on the surface of Cu porous material. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
DOI : 10.1002/jbm.a.31688
ISSN: 1549-3296
Sayı: 1
Cilt: 87A
Sayfa: 33-37

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