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Response to: “Reply to ‘Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients’: To consider varicella-like exanthem associated with COVID-19, virus varicella zoster and virus herpes simplex must be ruled out”
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Kaynak :
Science Direct
Dergi:
Journal of the American Academy of Dermatology
Yayıncı:
Elsevier
Yazar(lar) :
Angelo Valerio Marzano , Giovanni Genovese
Yıl :
2020
Angelo Valerio Marzano
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DOI : 10.1016/j.jaad.2020.05.072
ISSN: 0190-9622
Sayı: 3
Cilt: 83
Sayfa: e255-e256
Sınıflandırma :
2
Pathogenesis of Psoriasis: Focus on Autoinflammation.
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Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Dermatopathology (Basel)
Yazar(lar) :
Angelo Valerio Marzano , Federica Derlino , Emilio Francesco Berti
Yıl :
2018
Angelo Valerio Marzano
Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1159/000486304
Anahtar Kelimeler : Autoinflammation, Interleukin-1, Neutrophilic dermatoses, Psoriasis, Pyoderma gangrenosum
Sınıflandırma :
3
Eosinophilic Dermatoses: Recognition and Management
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Kaynak :
Springer Link
Dergi:
American Journal of Clinical Dermatology
Yazar(lar) :
Angelo Valerio Marzano , Giovanni Genovese
Konu :
Dermatology, General Medicine
Yıl :
2020
Angelo Valerio Marzano
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Eosinophilic dermatoses encompass a broad spectrum of diseases of different etiologies hallmarked by eosinophilic infiltration of the skin and/or mucous membranes, with or without associated blood eosinophilia. The wide range of dermatological manifestations of this spectrum, including nodules and plaques, pustules, blisters, ulcers, and urticarial lesions, is reflected in a non-univocal classification system. We identified six groups of eosinophilic dermatoses based on the predominant anatomic level of involvement: (1) epidermal; (2) of the dermal–epidermal junction; (3) dermal; (4) of the hypodermis and muscle fascia; (5) of the pilosebaceous unit; and (6) vascular/perivascular. We review clinicopathologic features and management of diseases belonging to each group, particularly: (1) pemphigus herpetiformis and atopic dermatitis as prototypes of the epidermal group; (2) bullous pemphigoid as prototypic eosinophilic dermatosis of the dermal–epidermal junction; (3) eosinophilic cellulitis (Wells syndrome), hypereosinophilic syndromes, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome, eosinophilic dermatosis of hematologic malignancy and chronic spontaneous urticaria as paradigmatic dermal eosinophilic dermatoses; (4) eosinophilic fasciitis as an eosinophilic dermatosis with predominant involvement of the hypodermis and muscle fascia; (5) eosinophilic pustular folliculitis as a model of the pilosebaceous unit involvement; and (6) granuloma faciale, angiolymphoid hyperplasia with eosinophilia, and eosinophilic granulomatosis with polyangiitis, belonging to the vascular/perivascular group.
DOI : 10.1007/s40257-020-00520-4
ISSN: 1175-0561 1179-1888
Sayı: 4
Cilt: 21
Sayfa: 525-539
4
Coagulation and Skin Autoimmunity
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Immunology
Yazar(lar) :
Massimo Cugno , Massimo Cugno , Alessandro Borghi , Simone Garcovich , Angelo Valerio Marzano , Angelo Valerio Marzano
Yıl :
2019
Angelo Valerio Marzano Angelo Valerio Marzano
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Several lines of evidence indicate that the immune system, inflammation, and coagulation are simultaneously activated in autoimmune and immune-mediated skin diseases. Pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha induce the expression of the main initiator of coagulation, i.e., tissue factor. The proteases of coagulation in turn act on protease-activated receptors inducing the expression of various pro-inflammatory cytokines triggering inflammation. The cross-talk among immune system, inflammation, and coagulation amplifies and maintains the activation of all three pathways. This review focuses on three skin disorders as chronic spontaneous urticaria (CSU), angioedema, and bullous pemphigoid (BP), in which the relationships among the three systems have been investigated or their clinical consequences are relevant. Markers of thrombin generation, fibrinolysis, and inflammation have been reported to be increased in the plasma during flares of CSU and angioedema, as well as in the active phase of BP, with the marker levels reverting to normal during remission. The coagulation activation seems to be important only at local level in CSU and angioedema while both at local and systemic levels in BP which is the only condition associated with an increased thrombotic risk. The prothrombotic state in autoimmune skin diseases raises the question of the indication of anticoagulant treatment, particularly in the presence of other cardiovascular risk factors.
DOI : 10.3389/fimmu.2019.01407
Anahtar Kelimeler : coagulation, autoimmunity, urticaria, angioedema, bullous pemphigoid, psoriasis
ISSN: 1664-3224
Cilt: 10
Sınıflandırma :
Biyotıp %100
Hematoloji %92
5
Oral and cutaneous findings are valuable diagnostic aids in Wegener's granulomatosis
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
European Journal of Internal Medicine
Yayıncı:
Elsevier
Yazar(lar) :
Angelo Valerio Marzano , Daniele Fanoni , Emilio Berti
Yıl :
2010
Angelo Valerio Marzano
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DOI : 10.1016/j.ejim.2009.09.013
Anahtar Kelimeler : Wegener's granulomatosis, Strawberry gingivitis, Mucocutaneous manifestations
ISSN: 0953-6205
Sayı: 1
Cilt: 21
Sayfa: 49
Sınıflandırma :
6
Neurologic Abnormalities in Two Patients with Facial Hemiatrophy and Sclerosis Coexisting with Morphea
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Pediatric Dermatology
Yazar(lar) :
Silvano Menni , Angelo Valerio Marzano , Emanuela Passoni
Konu :
Pediatrics, Perinatology, and Child Health, Dermatology
Yıl :
1997
Angelo Valerio Marzano
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DOI : 10.1111/j.1525-1470.1997.tb00216.x
ISSN: 0736-8046
Sayı: 2
Cilt: 14
Sayfa: 113-116
7
Ulcerative versus non‐ulcerative panniculitis: is it time for a novel clinical approach to panniculitis?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Eran Shavit , Angelo Valerio Marzano , Afsaneh Alavi
Konu :
Dermatology
Yıl :
2020
Angelo Valerio Marzano
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Panniculitis, or inflammation of the fatty tissue, is an ongoing diagnostic challenge to both dermatologists and pathologists. The basis of the current panniculitis classification is histology, whether the inflammation is mainly located in the fibrovascular septa or in the adipose lobules thereafter with or without vasculitis. However, overall, the difficulty rises due to various terminologies and lack of clinical relevance with this classification. In addition to that, the majority of panniculitides have mixed infiltration of both lobular and septal and not a clear‐cut distinction. The aim of this article is to provide a novel clinical algorithm to the diagnosis of panniculitis and thus to provide guidelines for all clinicians who may encounter this challenging condition in their clinical practice.
DOI : 10.1111/ijd.15224
ISSN: 0011-9059
Sayı: 4
Cilt: 60
Sayfa: 407-417
8
Pyoderma gangrenosum-like ulcerations in granulomatosis with polyangiitis: two cases and literature review.
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Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Rheumatol. Int.
Yazar(lar) :
Giovanni Genovese , Simona Tavecchio , Emilio Berti , Franco Rongioletti , Angelo Valerio Marzano
Yıl :
2018
Angelo Valerio Marzano
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Granulomatosis with polyangiitis (GPA) is a systemic necrotizing small vessel vasculitis associated with circulating anti-neutrophil cytoplasmic antibodies (ANCAs). Skin manifestations, mostly represented by palpable purpura, papulonodular lesions and livedo reticularis, are present in up to 50% of the cases. Ulcerations with undermined, raised erythematous-violaceous border resembling pyoderma gangrenosum (PG) have rarely been reported as skin involvement in GPA. The presence of circulating ANCAs with a cytoplasmic labelling pattern, the involvement of internal organs, particularly of the lung, and the absence on histology of a mainly neutrophilic infiltrate in early phases of the cutaneous lesions may be regarded as clues to rule out true PG and confirm the diagnosis of GPA skin ulcerations simulating PG. Herein, we describe two paradigmatic cases of such a unique presentation of GPA and a literature review focusing on clinicopathological features of GPA presenting with PG-like ulcerations in the skin has been provided. Moreover, referring to the scenario observed in these two cases, an easy-to-use working approach for the differential diagnosis between the two conditions has also been proposed.
DOI : 10.1007/s00296-018-4035-z
Anahtar Kelimeler : ANCA-associated vasculitis, Granulomatosis with polyangiitis, Pyoderma gangrenosum
Sınıflandırma :
9
Chronic urticaria: a focus on pathogenesis version 1; referees: 3 approved
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Yazar(lar) :
Riccardo Asero , Alberto Tedeschi , Angelo Valerio Marzano , Massimo Cugno
Yıl :
2017
Angelo Valerio Marzano
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Kaydet Alıntıla
Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality of life and sometimes represent a challenge for doctors as well. The causes of chronic urticaria are still poorly defined, although there is growing evidence that different biologic systems including immunity, inflammation, and coagulation may take part in the pathomechanism eventually leading to mast cell and basophil degranulation and hence to wheal formation. This review will discuss the main findings that are (slowly) shedding light on the pathogenesis of this disorder.
DOI : 10.12688/f1000research.11546.1
Anahtar Kelimeler : Immunopharmacology & Hematologic Pharmacology, Innate Immunity, Leukocyte Signaling & Gene Expression, Urticaria, Vasculitis & Connective Tissue Disease
ISSN: 2046-1402
Cilt: 6
10
A unique pneumopathy in a patient with skin nodules and abscesses
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Giovanni Damiani , Nicola di Meo , Angelo Valerio Marzano
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2017
Angelo Valerio Marzano
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DOI : 10.1007/s11739-017-1658-0
Anahtar Kelimeler : Adalimumab, Interstitial Lung Disease, Hidradenitis Suppurativa, Autoinflammatory Disease, Neutrophilic Dermatosis
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 12
Sayfa: 637-640
11
Main Oral Manifestations in Immune-Mediated and Inflammatory Rheumatic Diseases
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Clinical Medicine
Yazar(lar) :
Roberta Gualtierotti , Angelo Valerio Marzano , Francesco Spadari , Massimo Cugno
Yıl :
2018
Angelo Valerio Marzano
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Oral manifestations are frequent in patients with rheumatic diseases. The aim of this review is to offer readers practical advice concerning the onset, diagnosis and treatment of the main oral manifestations encountered in rheumatological and dental clinics. Signs and symptoms such as oral hyposalivation, xerostomia, temporomandibular joint disorders, periodontal disease, and dysphagia may be the first expression of a number of rheumatic diseases. Some of these manifestations are aspecific and very frequent, such as oral aphthosis, which can be the first manifestation in patients with systemic lupus erythematosus; some are potentially dangerous, such as jaw claudication during the course of giant cell arteritis; and some are very rare but peculiar, such as strawberry-like gingivitis in patients with granulomatosis with polyangiitis. Other oral manifestations are due to adverse reactions to disease-modifying anti-rheumatic drugs. Oral alterations in rheumatic diseases are frequently overlooked in clinical practice, but their prompt recognition not only allows the local lesions to be appropriately treated, but also makes it possible to identify an underlying systemic disease.
DOI : 10.3390/jcm8010021
Anahtar Kelimeler : rheumatoid arthritis, systemic lupus erythematosus, Behçetu2019s disease, Sjögrenu2019s syndrome, oral lesions
ISSN: 2077-0383
Cilt: 8
Sayı: 1
Sayfa: 21
Sınıflandırma :
12
Paradoxical Skin Reactions to Biologics in Patients With Rheumatologic Disorders
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pharmacology
Yazar(lar) :
Simone Garcovich , Clara De Simone , Giovanni Genovese , Giovanni Genovese , Emilio Berti , Emilio Berti , Massimo Cugno , Massimo Cugno , Angelo Valerio Marzano , Angelo Valerio Marzano
Yıl :
2019
Angelo Valerio Marzano Angelo Valerio Marzano
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Targeted immune-modulating treatment with biological agents has revolutionized the management of immune-mediated inflammatory diseases, including rheumatologic conditions. The efficacy and tolerability of biological agents, from the initial tumour necrosis factor (TNF)-α inhibitors to the new anti-cytokine monoclonal antibodies, have dramatically changed the natural history of debilitating conditions such as rheumatoid arthritis and seronegative spondyloarthropathies. The widening use of biologics across several rheumatologic diseases has been associated with a new class of adverse events, the so-called paradoxical reactions. These events are inflammatory immune-mediated tissue reactions, developing paradoxically during treatment of rheumatologic conditions with targeted biologics that are commonly used for treating the idiopathic counterparts of these drug-induced reactions. The skin is frequently involved, and, even if considered rare to uncommon, these cutaneous manifestations are an important cause of biologic agent discontinuation. TNF-α antagonist-induced psoriasis, which can manifest de novo or as exacerbation of a pre-existing form, is the prototypic and most frequent paradoxical skin reaction to biologics while other reactions, such as eczematous and lichenoid eruptions, hidradenitis suppurativa, pyoderma gangrenosum, Sweet’s syndrome and granulomatous skin diseases, occur much more rarely. Management of these reactions consists of topical or systemic skin-directed therapies, depending on the severity and extension of the cutaneous picture, and it is generally associated with switching over to other disease-modifying regimens for treating the underlying rheumatologic condition. Here, we review in detail the current concepts and controversies on classification, pathogenesis and clinical management of this new class of cutaneous adverse events induced by biologics in rheumatologic patients.
DOI : 10.3389/fphar.2019.00282
Anahtar Kelimeler : paradoxical skin reactions, biologics, rheumatological disorders, psoriasis, TNFα-inhibitors
ISSN: 1663-9812
Cilt: 10
Sınıflandırma :
13
Coagulation in Chronic Urticaria
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Current Treatment Options in Allergy
Yazar(lar) :
Riccardo Asero , Alberto Tedeschi , Angelo Valerio Marzano , Massimo Cugno
Yıl :
2015
Angelo Valerio Marzano
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There is increasing evidence that the coagulation cascade may play a role in the pathophysiology of chronic urticaria, particularly in severely active forms. Although anticoagulant therapy is presently not included among the standard treatments of severe chronic urticaria, based on the limited, but encouraging, literature presently available either warfarin or heparin could be considered as an add-on therapy in severely affected patients that do not respond to either antihistamines, omalizumab or ciclosporin, showing elevated plasma levels of D-dimer.
DOI : 10.1007/s40521-015-0062-0
Anahtar Kelimeler : Chronic urticaria, Coagulation, Thrombin, Tissue Factor, Eosinophils, Heparin, Oral anticoagulants
ISSN: 2196-3053
Sayı: 4
Cilt: 2
Sayfa: 287-293
14
Possible new inflammatory side-effect of SGLT2-inhibitors: Fixed drug eruption
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Diabetes and its Complications
Yayıncı:
Elsevier
Yazar(lar) :
Giovanni Damiani , Ulvi Loite , Stefano Ramoni , Angelo Valerio Marzano
Yıl :
2016
Angelo Valerio Marzano
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DOI : 10.1016/j.jdiacomp.2016.08.002
ISSN: 1056-8727
Sayı: 8
Cilt: 30
Sayfa: 1530-1531
Sınıflandırma :
15
Unusual variants of non-Langerhans cell histiocytoses
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of the American Academy of Dermatology
Yayıncı:
Elsevier
Yazar(lar) :
Ruggero Caputo , Angelo Valerio Marzano , Emanuela Passoni , Emilio Berti
Yıl :
2007
Angelo Valerio Marzano
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Kaydet Alıntıla
Histiocytic syndromes represent a large, heterogeneous group of diseases resulting from proliferation of histiocytes. In addition to the classic variants, the subset of non-Langerhans cell histiocytoses comprises rare entities that have more recently been described. These last include both forms that affect only the skin or the skin and mucous membranes, and usually show a benign clinical behavior, and forms involving also internal organs, which may follow an aggressive course. The goal of this review is to outline the clinical, histologic, and ultrastructural features and the course, prognosis, and management of these unusual histiocytic syndromes.
DOI : 10.1016/j.jaad.2007.03.014
Anahtar Kelimeler : BCH benign cephalic histiocytosis, benign cephalic histiocytosis, ECD Erdheim-Chester disease, Erdheim-Chester disease, GEH generalized eruptive histiocytosis, generalized eruptive histiocytosis, HPMH hereditary progressive mucinous histiocytosis, hereditary progressive mucinous histiocytosis, IC indeterminate cell, indeterminate cell, ICH indeterminate cell histiocytosis, indeterminate cell histiocytosis, JXG juvenile xanthogranuloma, juvenile xanthogranuloma, LC Langerhans cell, Langerhans cell, LCH Langerhans cell histiocytoses, Langerhans cell histiocytoses, MR multicentric reticulohistiocytosis, multicentric reticulohistiocytosis, PNH progressive nodular histiocytosis, progressive nodular histiocytosis, PX papular xanthoma, papular xanthoma, SBH sea-blue histiocyte, sea-blue histiocyte, SBHS sea-blue histiocytic syndrome, sea-blue histiocytic syndrome, XD xanthoma disseminatum, xanthoma disseminatum
ISSN: 0190-9622
Sayı: 6
Cilt: 57
Sayfa: 1031-1045
Sınıflandırma :
16
Post-surgical Thyroid Bed Pyoderma Gangrenosum Mimicking Recurrent Papillary Thyroid Carcinoma
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Endocrinology
Yazar(lar) :
Alessia Dolci , Alessia Dolci , Rita Indirli , Rita Indirli , Giovanni Genovese , Giovanni Genovese , Federica Derlino , Maura Arosio , Maura Arosio , Angelo Valerio Marzano , Angelo Valerio Marzano
Yıl :
2019
Angelo Valerio Marzano Angelo Valerio Marzano
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Background: Pyoderma gangrenosum (PG) is a rare inflammatory disease presenting with chronic-recurrent cutaneous ulcers histopathologically hallmarked by neutrophilic infiltrates, which may occur more frequently at sites of surgical traumas. The disease is habitually limited to the skin, but it can virtually involve any organ. Nevertheless, no prior cases of PG involving the thyroid bed have ever been reported.Case Report: A bilateral PG of the breast was diagnosed in a 51-year-old woman and treated with intravenous methylprednisolone pulse-therapy and cyclosporine, with partial improvement. During the hospitalization, cytological examination of two hypoechoic thyroid nodules by fine-needle aspiration (FNA) was consistent with thyroid carcinoma. After total thyroidectomy, histopathology confirmed a papillary thyroid cancer (PTC), and radioactive iodine ablation was performed. At 12-month ultrasonographic follow-up, two hypoechoic avascular areas localized in the empty thyroid bed raised the suspect of PTC recurrence. However, (i) undetectable levels of thyroglobulin without anti-thyroglobulin antibodies, (ii) neutrophilia and increased inflammatory marker levels, and (iii) cytological examination of FNA showing numerous neutrophils induced to suspect thyroid bed PG infiltration. An ex juvantibus approach with high-dose methylprednisolone led to dimensional reduction of the hypoechoic areas on ultrasonography, thus confirming the hypothesis of thyroid bed PG.Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG.
DOI : 10.3389/fendo.2019.00253
Anahtar Kelimeler : pyoderma gangrenosum, differentiated thyroid carcinoma, papillary thyroid carcinoma, pathergy, thyroidectomy
ISSN: 1664-2392
Cilt: 10
Sınıflandırma :
17
Cutaneous manifestations in systemic vasculitis
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Clinical Reviews in Allergy & Immunology
Yazar(lar) :
Irene Decleva , Angelo Valerio Marzano , Mauro Barbareschi , Emilio Berti
Konu :
General Medicine, Immunology and Allergy
Yıl :
1997
Angelo Valerio Marzano
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Kaydet Alıntıla
This article has emphasized the extreme polymorphism of cutaneous manifestations in the course of systemic vasculitis. Skin involvement, which may represent the onset of the clinical picture in many cases, does not permit an immediate diagnosis but may orient the physician to further investigations. In our experience most patients who are referred to the dermatologist suffer from cutaneous features in apparent absence of visceral involvement. This group of patients forms a distinct subset of vasculitis characterized by the same polymorphic pattern of skin lesions observed in the systemic forms. The rare involvement of multiorgan systems suggests the existence of a continuum between cutaneous forms and systemic vasculitic syndromes as classified by the ARA. The causes of this protean clinical expression should be further investigated: different and, until now, unrecognized factors may act synergistically with common pathogenetic mechanisms. These factors could be represented by the existence of particular lymphocyte subsets with selective skin homing or by an anatomical background. The similarity of the therapeutic approach provides additional evidence for this unifying hypothesis.
DOI : 10.1007/bf02828274
Anahtar Kelimeler : Vasculitis, Dermatol, Kawasaki Disease, Clinical Review, Giant Cell Arteritis
ISSN: 1080-0549 1559-0267
Sayı: 1
Cilt: 15
Sayfa: 5-20
18
New Insights Into the Pathogenesis of Bullous Pemphigoid: 2019 Update
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Immunology
Yazar(lar) :
Giovanni Genovese , Giovanni Genovese , Giovanni Di Zenzo , Emanuele Cozzani , Emilio Berti , Emilio Berti , Massimo Cugno , Massimo Cugno , Angelo Valerio Marzano , Angelo Valerio Marzano
Yıl :
2019
Angelo Valerio Marzano Angelo Valerio Marzano
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There are several lines of evidence indicating that the physiopathological bases of bullous pemphigoid (BP), the most common subepidermal autoimmune bullous disease, are hallmarked by the production of autoantibodies directed against the hemidesmosomal anchoring proteins BP180 and BP230. In contrast to the robustness of the latter assumption, the multifaceted complexity of upstream and downstream mechanisms implied in the pathogenesis of BP remains an area of intense speculation. So far, an imbalance between T regulatory cells and autoreactive T helper (Th) cells has been regarded as the main pathogenic factor triggering the autoimmune response in BP patients. However, the contributory role of signaling pathways fostering the B cell stimulation, such as Toll-like receptor activation, as well as that of ancillary inflammatory mechanisms responsible for blister formation, such as Th17 axis stimulation and the activation of the coagulation cascade, are still a matter of debate. In the same way, the pathomechanisms implied in the loss of dermal-epidermal adhesion secondary to autoantibodies binding are not fully understood. Herein, we review in detail the current concepts and controversies on the complex pathogenesis of BP, shedding light on the most recent theories emerging from the literature.
DOI : 10.3389/fimmu.2019.01506
Anahtar Kelimeler : bullous pemphigoid, pathogenesis, autoantibodies, autoimmunity, autoimmune blistering diseases
ISSN: 1664-3224
Cilt: 10
Sınıflandırma :
19
Pancreatic panniculitis: the “bright” side of the moon in solid cancer patients
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
BMC Gastroenterology
Yazar(lar) :
Elena Guanziroli , Antonella Colombo , Antonella Coggi , Raffaele Gianotti , Angelo Valerio Marzano
Yıl :
2018
Angelo Valerio Marzano
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Abstract Background Pancreatic panniculitis is a rare complication of pancreas disorders occurring in 0.3–3% of patients, most often accompanied by the pancreatic acinar carcinoma. It presents multiple, painful, deep, ill-defined, red-brown, migratory nodules and plaques of hard elastic consistency; often ulcerated and typically located on the lower proximal and distal extremities. The pathogenesis is not fully understood, but it is thought to result from lipolysis and fat necrosis with secondary tissue inflammation induced by pancreatic enzymes. Histopathology shows subcutaneous lobular fat necrosis with anuclear adipocytes (called ghost cells) surrounded by a mixed inflammatory infiltrate. Focal calcification may also be seen. The treatment is directed to the underlying disorder, which may result in regression of skin lesions. Case presentation We present two cases of pancreatic panniculitis with similar clinical, laboratory, and histopathological features associated with different internal malignancy. The first case, after extensive investigations showed the presence of a pancreatic carcinoma with multiple liver metastases and a poor prognosis. The second one instead is the first case in literature where painful subcutaneous nodules of the legs were the early manifestation of a neuroendocrine carcinoma of the adrenal gland. Conclusions Although subcutaneous fat necrosis usually occurs late in the course of a malignancy, recognition of the association with pancreatic panniculitis may prevent a long delay in the diagnosis and management of the occult neoplasm. It should be primarily considered when panniculitis is widespread and persistent, and frequent relapses or tendency to ulcerate of the nodules are regarded as red flags.
DOI : 10.1186/s12876-017-0727-1
Anahtar Kelimeler : Pancreatic panniculitis, Pancreatic cancer, Subcutaneous fat necrosis
ISSN: 1471-230X
Cilt: 18
Sayı: 1
Sayfa: 1 - 4
Sınıflandırma :
20
Refractory disseminated superficial actinic porokeratosis effectively treated with cholesterol/lovastatin cream: A case report
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Dermatologic Therapy
Yazar(lar) :
Carlo Alberto Maronese , Giovanni Genovese , Carmelo Genovese , Angelo Valerio Marzano
Konu :
Dermatology, General Medicine
Yıl :
2020
Angelo Valerio Marzano
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Tam Metin
Kaydet Alıntıla
DOI : 10.1111/dth.14583
ISSN: 1396-0296

Sınıflandırma :
21
Inflammatory Joint Disorders and Neutrophilic Dermatoses: a Comprehensive Review
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Clinical Reviews in Allergy & Immunology
Yazar(lar) :
Massimo Cugno , Roberta Gualtierotti , Pier Luigi Meroni , Angelo Valerio Marzano
Konu :
General Medicine, Immunology and Allergy
Yıl :
2017
Angelo Valerio Marzano
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Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates. Inflammatory joint disorders and neutrophilic dermatoses share a number of pathophysiological features related to their cytokine overexpression profile. Moreover, any organ system can be potentially involved in neutrophilic dermatoses, giving rise to the concept of neutrophilic disease. Among the extracutaneous manifestations of neutrophilic disease, joint involvement is regarded as the most common. It is not associated with erosions and disability and usually responds to treatment for skin involvement, consisting of systemic corticosteroids and, in refractory cases, immunosuppressants or biologics. Arthritis may also be the initial manifestation of rheumatoid arthritis or spondyloarthritis, which has a chronic or recurrent course and requires a continuous treatment with synthetic or biologic disease-modifying anti-rheumatic drugs. If not properly treated, they may be associated with disability and reduced quality of life. Skin lesions occurring during the course of rheumatoid arthritis and spondyloarthritis require a multidisciplinary approach envisaging the collaboration of dermatologists and rheumatologists in order to achieve early diagnosis and treatment. Several biomarkers may help the clinician in the differential diagnosis of arthritis while histology is pivotal for the correct classification of the skin disease. However, in some cases, only regular follow-up allows a definite diagnosis. In this review article, we focus on the prototypic neutrophilic dermatoses like pyoderma gangrenosum, Sweet’s syndrome, hidradenitis suppurativa and their syndromic forms as well as on their articular involvement, providing a simple approach for their diagnosis and therapy.
DOI : 10.1007/s12016-017-8629-0
Anahtar Kelimeler : Neutrophilic dermatosis, Rheumatoid arthritis, Spondyloarthritis, Inflammatory joint disorder, Biological drug
ISSN: 1080-0549 1559-0267
Sayı: 2
Cilt: 54
Sayfa: 269-281
22
Pyoderma gangrenosum: Study of 21 patients and proposal of a ‘clinicotherapeutic’ classification
Dergi Makalesi

Dergi Makalesi
Kaynak :
Taylor and Francis
Dergi:
Journal of Dermatological Treatment
Yayıncı:
Informa UK Limited
Yazar(lar) :
Angelo Valerio Marzano , Valentina Trevisan , Riccardo Lazzari , Carlo Crosti
Yıl :
2010
Angelo Valerio Marzano
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Background: Pyoderma gangrenosum (PG) is a rare, relapsing inflammatory disorder classified within the neutrophilic dermatoses. It can be idiopathic or associated with various conditions. The management of PG includes several immunosuppressants, but definite guidelines are still lacking. Objective: To propose a ‘clinicotherapeutic’ classification for PG; namely, a therapeutic algorithm for this disease on the basis of the clinical extent of lesions. Methods: Twenty-one patients with PG referred to our department during the last 3½ years were prospectively studied. They were subdivided into three subsets localized, multilesional and disseminated on the basis of the number of lesions and percentage of involved body surface area. Results: The end point was fulfilled in all the aforementioned settings of PG. Topical tacrolimus proved to be useful in localized PG. Multilesional PG was successfully treated with prednisone alone or in combination with cyclosporine. Disseminated PG responded well to prednisone plus cyclosporine, except for refractory cases in which infliximab was employed. Conclusions: This clinicotherapeutic classification seems to work well in PG, although its impact on the incidence of relapses is poorly evaluable due to the short follow-ups in our study; controlled trials are needed to confirm its value.
DOI : 10.3109/09546631003686069
Anahtar Kelimeler : classification, cyclosporine, infliximab, prednisone, pyoderma gangrenosum, topical tacrolimus
ISSN: 0954-6634
Sayı: 5
Cilt: 22
Sayfa: 254-260
23
The use of Biochip immunofluorescence microscopy for the serological diagnosis of epidermolysis bullosa acquisita
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Archives of Dermatological Research
Yazar(lar) :
Angelo Valerio Marzano , Emanuele Cozzani , Matteo Biasin , Irene Russo , Mauro Alaibac
Konu :
Dermatology, General Medicine
Yıl :
2016
Angelo Valerio Marzano
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Epidermolysis bullosa acquisita is a rare autoimmune bullous disease characterized by the presence of circulating antibodies directed against the collagen type VII. Diagnosis is generally based on clinical history, clinical features, histology, direct and indirect immunofluorescence, immunoblotting and ELISA. Our study aims to determine the validity of the Biochip immunofluorescence microscopy for the serological diagnosis of epidermolysis bullosa acquisita. Six patients with epidermolysis bullosa acquisita and presence of antibodies against type VII collagen confirmed by ELISA were included in the study. Subsequently, all sera of patients were analyzed using Biochip. Antibodies anti-collagen type VII were detected in all sera by means of the Biochip technology. Thus, Biochip shows a good correlation with ELISA and seems to be an appropriate method for the diagnosis of epidermolysis bullosa acquisita. It is an easy, fast and standardized method which could facilitate the diagnosis of this autoimmune bullous disease. We suggest that it could be used as an initial screening test to identify patients with epidermolysis bullosa acquisita.
DOI : 10.1007/s00403-016-1632-0
Anahtar Kelimeler : Epidermolysis bullosa acquisita, Serological diagnosis, Biochip technology, ELISA
ISSN: 0340-3696 1432-069X
Sayı: 4
Cilt: 308
Sayfa: 273-276
24
A sweet fever.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Intern Emerg Med
Yazar(lar) :
Silvia Tiraboschi , Angelo Valerio Marzano , Rosa Lombardi , Giovanni Genovese , Giovanni Boccoli , Silvia Fargion , Anna Ludovica Fracanzani
Yıl :
2018
Angelo Valerio Marzano
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DOI : 10.1007/s11739-018-1975-y
Sınıflandırma :
25
PASH, PAPASH, PsAPASH and PASS: the autoinflammatory syndromes of hidradenitis suppurativa
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Clinics in Dermatology
Yayıncı:
Elsevier
Yazar(lar) :
Simone Garcovich , Giovanni Genovese , Chiara Moltrasio , Dalma Malvaso , Angelo Valerio Marzano
Yıl :
2020
Angelo Valerio Marzano
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Hidradenitis suppurativa (HS) is a chronic inflammatory disease usually involving the major skin folds characterized by a multifactorial pathogenesis and a wide spectrum of clinical manifestations. It can also rarely present in association with other diseases as complex clinical syndromes, causing additional diagnostic and therapeutic challenges. Different etiopathologic factors contribute to follicular inflammation and suppurative lesions of syndromic HS, including follicular hyperkeratinization and plugging, as well as activation of autoinflammatory pathways. Patients with syndromic HS frequently have a severe disease course, presenting with atypical skin involvement, signs of systemic inflammation, and resistance to conventional treatments. Systematic classification of syndromic HS is based on clinical, pathogenetic, and genetic factors, but it is constantly evolving due to increased disease awareness. Treatment of syndromic HS is difficult and should be personalized on a case-by-case basis. Investigating syndromic HS can lead to useful insights on genetics and pathogenesis, translating into new clinical approaches for sporadic hidradenitis. We review the classification, clinical presentation, disease associations, and therapeutic management of syndromic HS, focusing mainly on its autoinflammatory syndromes PASH, PAPASH, PsAPASH, and PASS.
DOI : 10.1016/j.clindermatol.2020.10.016
ISSN: 0738-081X

Sınıflandırma :
26
Comparison of clinical and sonographic scores in a cohort of 140 patients with hidradenitis suppurativa from an Italian referral centre: a retrospective observational study.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Eur J Dermatol
Yazar(lar) :
Gianluca Nazzaro , Emanuela Passoni , Elena Guanziroli , Giovanni Casazza , Simona Muratori , Mauro Barbareschi , Stefano Veraldi , Angelo Valerio Marzano
Yıl :
2018
Angelo Valerio Marzano
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DOI : 10.1684/ejd.2018.3430
Sınıflandırma :
27
Phenotypic switch from atopic dermatitis to psoriasis during treatment with upadacitinib
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Clinical and Experimental Dermatology
Yazar(lar) :
Silvia Mariel Ferrucci , Stefano Buffon , Angelo Valerio Marzano , Carlo Alberto Maronese
Yıl :
2022
Angelo Valerio Marzano
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DOI : 10.1111/ced.15104
ISSN: 0307-6938

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