Piri Keşif Aracı

Özet Ek Bilgiler

Kaydet

Molecular typing methods based on the analysis of the genetic structure of bacteria, are used to address many different problems such as the study of genomic organisation and evolution, the identification of patterns of infection, the identification of sources of transmission, the epidemiological surveillance of infectious diseases and for investigations into outbreaks. Of particular interest is the application of these techniques for acquiring information on the spread of micro-organisms that have become resistant to many clinically important antibiotics. The emergence of antibiotic resistance is one of the most dangerous phenomena of the last 20 years and knowledge of the mechanisms of resistant-gene exchange means fully understanding their spread into all environments. Studies on the molecular epidemiology of antibiotic-resistance in micro-organisms should make it easier to distinguish clonality with respect to horizontal transfer of the determinants of resistance.

DOI : 10.1016/s0924-8579(99)00103-x

Anahtar Kelimeler : Molecular epidemiology, Antibiotic resistance, Molecular chronometers

ISSN: 0924-8579
Sayı: 3
Cilt: 13
Sayfa: 143-153

Sınıflandırma :

Biyotıp %40

İlaç Direnci %100

Yaşam Bilimleri %29

Tıbbi Mikrobiyoloji %72

2

The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity

Dergi Makalesi

Kaynak 1:

Wiley Online Library

Kaynak 2:

PubMed

Dergi:

Acta Ophthalmologica

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Antonella Agodi

Konu :

Ophthalmology, General Medicine

Yıl :

2018

Antonella Agodi

Ek Bilgiler

Kaydet

Kaynak 1:

https://onlinelibrary.wiley.com/doi/10.1111/aos.13849 arayıcılığı görüntüle.
Kaynak 2:

https://www.ncbi.nlm.nih.gov/pubmed/30280493 arayıcılığı görüntüle.

DOI : 10.1111/aos.13849

ISSN: 1755-375X
Sayı: 1
Cilt: 97
Sayfa: e8-e21

3

A Clustering Approach to Classify Italian Regions and Provinces Based on Prevalence and Trend of SARS-CoV-2 Cases

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

International Journal of Environmental Research and Public Health

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Antonella Agodi

Yıl :

2020

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

While several efforts have been made to control the epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Italy, differences between and within regions have made it difficult to plan the phase two management after the national lockdown. Here, we propose a simple and immediate clustering approach to categorize Italian regions working on the prevalence and trend of SARS-CoV-2 positive cases prior to the start of phase two on 4 May 2020. Applying both hierarchical and k-means clustering, we identified three regional groups: regions in cluster 1 exhibited higher prevalence and the highest trend of SARS-CoV-2 positive cases; those classified into cluster 2 constituted an intermediate group; those in cluster 3 were regions with a lower prevalence and the lowest trend of SARS-CoV-2 positive cases. At the provincial level, we used a similar approach but working on the prevalence and trend of the total SARS-CoV-2 cases. Notably, provinces in cluster 1 exhibited the highest prevalence and trend of SARS-CoV-2 cases. Provinces in clusters 2 and 3, instead, showed a median prevalence of approximately 11 cases per 10,000 residents. However, provinces in cluster 3 were those with the lowest trend of cases. K-means clustering yielded to an alternative cluster solution in terms of the prevalence and trend of SARS-CoV-2 cases. Our study described a simple and immediate approach to monitor the SARS-CoV-2 epidemic at the regional and provincial level. These findings, at present, offered a snapshot of the epidemic, which could be helpful to outline the hierarchy of needs at the subnational level. However, the integration of our approach with further indicators and characteristics could improve our findings, also allowing the application to different contexts and with additional aims.

Kaynak 1:

https://doi.org/10.3390/ijerph17155286 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/ijerph17155286 arayıcılığı görüntüle.

DOI : 10.3390/ijerph17155286

Anahtar Kelimeler : COVID-19, clustering, positive cases, epidemiology

Cilt: 17
Sayı: 5286
Sayfa: 5286

Sınıflandırma :

Tıp ve Halk Sağlığı %28

Halk Sağlığı %50

Coğrafya %22

Jeofizik ve Jeodezi %35

Dünya Bölgesel Coğrafyası %21

4

Modeling the Novel Coronavirus (SARS-CoV-2) Outbreak in Sicily, Italy

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

International Journal of Environmental Research and Public Health

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Sebastiano Battiato , Antonella Agodi

Yıl :

2020

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Italy was the first country in Europe which imposed control measures of travel restrictions, quarantine and contact precautions to tackle the epidemic spread of the novel coronavirus (SARS-CoV-2) in all its regions. While such efforts are still ongoing, uncertainties regarding SARS-CoV-2 transmissibility and ascertainment of cases make it difficult to evaluate the effectiveness of restrictions. Here, we employed a Susceptible-Exposed-Infectious-Recovered-Dead (SEIRD) model to assess SARS-CoV-2 transmission dynamics, working on the number of reported patients in intensive care unit (ICU) and deaths in Sicily (Italy), from 24 February to 13 April. Overall, we obtained a good fit between estimated and reported data, with a fraction of unreported SARS-CoV-2 cases (18.4%; 95%CI = 0–34.0%) before 10 March lockdown. Interestingly, we estimated that transmission rate in the community was reduced by 32% (95%CI = 23–42%) after the first set of restrictions, and by 80% (95%CI = 70–89%) after those adopted on 23 March. Thus, our estimates delineated the characteristics of SARS-CoV2 epidemic before restrictions taking into account unreported data. Moreover, our findings suggested that transmission rates were reduced after the adoption of control measures. However, we cannot evaluate whether part of this reduction might be attributable to other unmeasured factors, and hence further research and more accurate data are needed to understand the extent to which restrictions contributed to the epidemic control.

Kaynak 1:

https://doi.org/10.3390/ijerph17144964 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/ijerph17144964 arayıcılığı görüntüle.

DOI : 10.3390/ijerph17144964

Anahtar Kelimeler : novel coronavirus, COVID-19, epidemic model, epidemiology

Cilt: 17
Sayı: 4964
Sayfa: 4964

Sınıflandırma :

Tıp ve Halk Sağlığı %41

Bulaşıcı Hastalıklar %91

Ekonomi %23

Demografi %34

Nüfus Ekonomisi %26

5

Estimation of Unreported Novel Coronavirus (SARS-CoV-2) Infections from Reported Deaths: A Susceptible–Exposed–Infectious–Recovered–Dead Model

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

Journal of Clinical Medicine

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Sebastiano Battiato , Antonella Agodi

Yıl :

2020

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In the midst of the novel coronavirus (SARS-CoV-2) epidemic, examining reported case data could lead to biased speculations and conclusions. Indeed, estimation of unreported infections is crucial for a better understanding of the current emergency in China and in other countries. In this study, we aimed to estimate the unreported number of infections in China prior to the 23 January 2020 restrictions. To do this, we developed a Susceptible–Exposed–Infectious–Recovered–Dead (SEIRD) model that estimated unreported infections from the reported number of deaths. Our approach relied on the fact that observed deaths were less likely to be affected by ascertainment biases than reported infections. Interestingly, we estimated that the basic reproductive number (R0) was 2.43 (95%CI = 2.42–2.44) at the beginning of the epidemic and that 92.9% (95%CI = 92.5%–93.1%) of total cases were not reported. Similarly, the proportion of unreported new infections by day ranged from 52.1% to 100%, with a total of 91.8% (95%CI = 91.6%–92.1%) of infections going unreported. Agreement between our estimates and those from previous studies proves that our approach is reliable for estimating the prevalence and incidence of undocumented SARS-CoV-2 infections. Once it has been tested on Chinese data, our model could be applied to other countries with different surveillance and testing policies.

Kaynak 1:

https://doi.org/10.3390/jcm9051350 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/jcm9051350 arayıcılığı görüntüle.

DOI : 10.3390/jcm9051350

Anahtar Kelimeler : novel coronavirus, COVID-19, epidemic model, epidemiology

ISSN: 2077-0383
Cilt: 9
Sayı: 1350
Sayfa: 1350

Sınıflandırma :

Tıp ve Halk Sağlığı %57

Bulaşıcı Hastalıklar %60

6

Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

Nutrients

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Isabella Blanco , Antonella Agodi

Yıl :

2019

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

During pregnancy, vitamin D supplementation may be a feasible strategy to help prevent low birthweight (LBW) and small for gestational age (SGA) births. However, evidence from randomized controlled trials (RCTs) is inconclusive, probably due to heterogeneity in study design and type of intervention. A systematic literature search in the PubMed-Medline, EMBASE, and Cochrane Central Register of Controlled Trials databases was carried out to evaluate the effects of oral vitamin D supplementation during pregnancy on birthweight, birth length, head circumference, LBW, and SGA. The fixed-effects or random-effects models were used to calculate mean difference (MD), risk ratio (RR), and 95% Confidence Interval (CI). On a total of 13 RCTs, maternal vitamin D supplementation had a positive effect on birthweight (12 RCTs; MD = 103.17 g, 95% CI 62.29⁻144.04 g), length (6 RCTs; MD = 0.22 cm, 95% CI 0.11⁻0.33 cm), and head circumference (6 RCTs; MD:0.19 cm, 95% CI 0.13⁻0.24 cm). In line with these findings, we also demonstrated that maternal vitamin D supplementation reduced the risk of LBW (3 RCTs; RR = 0.40, 95% CI 0.22⁻0.74) and SGA (5 RCTS; RR = 0.69, 95% CI 0.51⁻0.92). The present systematic review and meta-analysis confirmed the well-established effect of maternal vitamin D supplementation on birth size. However, further research is required to better define risks and benefits associated with such interventions and the potential implications for public health.

Kaynak 1:

https://doi.org/10.3390/nu11020442 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/nu11020442 arayıcılığı görüntüle.

DOI : 10.3390/nu11020442

Anahtar Kelimeler : nutrition, vitamin D, birthweight, birth length, head circumference, gestational age, pregnancy outcomes

ISSN: 2072-6643
Cilt: 11
Sayı: 2
Sayfa: 442

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Anne ve Çocuk Sağlığı %100

7

Detection of genetically modified DNA sequences in milk from The Italian market

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

International Journal of Hygiene and Environmental Health

Yayıncı:

Elsevier

Yazar(lar) :

Antonella Agodi , Martina Barchitta , Agata Grillo , Salvatore Sciacca

Yıl :

2006

Antonella Agodi

Özet Ek Bilgiler

Kaydet

The possible transfer and accumulation of novel DNA and/or proteins in food for human consumption derived from animals receiving genetically modified (GM) feed is at present the object of scientific dispute. A number of studies failed to identify GM DNA in milk, meat, or eggs derived from livestock receiving GM feed ingredients. The present study was performed in order to: (i) develop a valid protocol by PCR and multicomponent analysis for the detection of specific DNA sequences in milk, focused on GM maize and GM soybean; (ii) assess the stability of transgenic DNA after pasteurization treatment and (iii) determine the presence of GM DNA sequences in milk samples collected from the Italian market. Results from the screening of 60 samples of 12 different milk brands demonstrated the presence of GM maize sequences in 15 (25%) and of GM soybean sequences in 7 samples (11.7%). Our screening methodology shows a very high sensitivity and the use of an automatic identification of the amplified products increases its specificity and reliability. Moreover, we demonstrated that the pasteurization process is not able to degrade the DNA sequences in spiked milk samples. The detection of GM DNA in milk can be interpreted as an indicator of fecal or airborne contamination, respectively, with feed DNA or feed particles, although an alternative source of contamination, possibly recognizable in the natural environment can be suggested. Further studies, performed on a larger number of milk samples, are needed to understand the likely source of contamination of milk collected from the Italian market.

DOI : 10.1016/j.ijheh.2005.08.005

ISSN: 1438-4639
Sayı: 1
Cilt: 209
Sayfa: 81-88

Sınıflandırma :

Yaşam Bilimleri %53

Tarım %28

8

DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis

Araştırma Makalesi

Kaynak 1:

PLOS - Public Library of Science

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Public Library of Science

Yazar(lar) :

Manlio Vinciguerra , Andrea Maugeri , Annalisa Quattrocchi , Martina Barchitta , Antonella Agodi

Yıl :

2015

Antonella Agodi

Özet Ek Bilgiler

Kaydet

Objective The Death-Associated Protein Kinase 1 (DAPK1) gene has been frequently investigated in cervical cancer (CC). The aim of the present study was to carry out a systematic review and a meta-analysis in order to evaluate DAPK1 promoter methylation as an epigenetic marker for CC risk. Methods A systematic literature search was carried out. The Cochrane software package Review Manager 5.2 was used. The fixed-effects or random-effects models, according to heterogeneity across studies, were used to calculate odds ratios (ORs) and 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by histological type, assays used to evaluate DAPK1 promoter methylation, and control sample source. Results A total of 20 papers, published between 2001 and 2014, on 1929 samples, were included in the meta-analysis. DAPK1 promoter methylation was associated with an increased CC risk based on the random effects model (OR: 21.20; 95%CI = 11.14–40.35). Omitting the most heterogeneous study, the between study heterogeneity decreased and the association increased (OR: 24.13; 95% CI = 15.83–36.78). The association was also confirmed in all the subgroups analyses. Conclusions A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples. Methylation markers may have value in early detection of CC precursor lesions, provide added reassurances of safety for women who are candidates for less frequent screens, and predict outcomes of women infected with human papilloma virus.

Kaynak 1:

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135078 arayıcılığı görüntüle.
Kaynak 2:

https://doi.org/10.1371/journal.pone.0135078 arayıcılığı görüntüle.

DOI : 10.1371/journal.pone.0135078

Anahtar Kelimeler : Methylation, DNA methylation, Meta-analysis, Biopsy, Histology, Squamous cell carcinomas, Lesions, Systematic reviews

Sınıflandırma :

Yaşam Bilimleri %70

Moleküler Tıp %88

Biyotıp %28

Epidemiyoloji %100

9

Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine.

Dergi Makalesi

Kaynak 1:

PubMed

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Biomed Res Int

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Maria Grazia Mazzone , Francesco Giuliano , Antonella Agodi

Yıl :

2018

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health. Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate. In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response. Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.

Kaynak 1:

https://www.ncbi.nlm.nih.gov/pubmed/28332910 arayıcılığı görüntüle.
Kaynak 2:

https://doi.org/10.1155/2018/7532507 arayıcılığı görüntüle.

DOI : 10.1155/2018/7532507

Sınıflandırma :

Tıp ve Halk Sağlığı %49

Sağlıklı Psikoloji %57

Biyotıp %40

Translasyon Sonrası Değişiklik %35

10

Epidemiology and Control of Urinary Tract Infections in Intensive Care Patients

e-Kitap

Kaynak :

IntechOpen

Yazar(lar) :

Antonella Agodi , Martina Barchitta

Yıl :

2011

Antonella Agodi

Ek Bilgiler

Kaydet

DOI : 10.5772/23113

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Bulaşıcı Hastalıklar %34

Yoğun ve Yoğun Bakım Tıbbı %24

Üroloji %24

11

Applying a hierarchical clustering on principal components approach to identify different patterns of the SARS-CoV-2 epidemic across Italian regions

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Scientific Reports

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Guido Basile , Antonella AgodiAndrea Maugeri , Martina Barchitta , Guido Basile , Antonella Agodi

Yıl :

2021

Antonella Agodi

Özet Ek Bilgiler

Kaydet

AbstractItaly has experienced the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2, which spread at different times and with different intensities throughout its territory. We aimed to identify clusters with similar epidemic patterns across Italian regions. To do that, we defined a set of regional indicators reflecting different domains and employed a hierarchical clustering on principal component approach to obtain an optimal cluster solution. As of 24 April 2020, Lombardy was the worst hit Italian region and entirely separated from all the others. Sensitivity analysis—by excluding data from Lombardy—partitioned the remaining regions into four clusters. Although cluster 1 (i.e. Veneto) and 2 (i.e. Piedmont and Emilia-Romagna) included the most hit regions beyond Lombardy, this partition reflected differences in the efficacy of restrictions and testing strategies. Cluster 3 was heterogeneous and comprised regions where the epidemic started later and/or where it spread with the lowest intensity. Regions within cluster 4 were those where the epidemic started slightly after Veneto, Emilia-Romagna and Piedmont, favoring timely adoption of control measures. Our findings provide policymakers with a snapshot of the epidemic in Italy, which might help guiding the adoption of countermeasures in accordance with the situation at regional level.

DOI : 10.1038/s41598-021-86703-3

ISSN: 2045-2322
Sayı: 1
Cilt: 11

12

The Association of Dietary Patterns with High-Risk Human Papillomavirus Infection and Cervical Cancer: A Cross-Sectional Study in Italy.

Dergi Makalesi

Kaynak 1:

PubMed

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Nutrients

Yazar(lar) :

Martina Barchitta , Andrea Maugeri , Annalisa Quattrocchi , Ottavia Agrifoglio , Aurora Scalisi , Antonella Agodi

Konu :

Adult, Case-Control Studies, Cervical Intraepithelial Neoplasia, Chi-Square Distribution, Cross-Sectional Studies, Diet, Mediterranean, Eating, Feeding Behavior, Female, Healthy Diet, Humans, Italy, Linear Models, Logistic Models, Middle Aged, Neoplasm Grading, Odds Ratio, Papillomavirus Infections, Principal Component Analysis, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Surveys and Questionnaires, Uterine Cervical Neoplasms

Yıl :

2018

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Specific foods and nutrients help prevent the progression of persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). The aim of this study was to investigate dietary patterns which may be associated with hrHPV status and the risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 with CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intake was estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with a normal cervical epithelium, medium adherence to the Mediterranean diet decreased the odds of hrHPV infection when compared to low adherence (adjOR = 0.40, 95%CI = 0.22-0.73). Using the principal component analysis, we also identified two dietary patterns which explained 14.31% of the variance in food groups intake. Women in the third and fourth quartiles of the "Western pattern" had higher odds of hrHPV infection when compared with first quartile (adjOR = 1.77, 95% CI = 1.04-3.54 and adjOR = 1.97, 95%CI = 1.14-4.18, respectively). Adjusting for hrHPV status and age, women in the third quartile of the "prudent pattern" had lower odds of CIN2+ when compared with those in the first quartile (OR = 0.50, 95%CI = 0.26-0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC and discourages unhealthy habits in favour of a Mediterranean-like diet.

Kaynak 1:

https://www.ncbi.nlm.nih.gov/pubmed/15574793 arayıcılığı görüntüle.
Kaynak 2:

https://doi.org/10.3390/nu10040469 arayıcılığı görüntüle.

DOI : 10.3390/nu10040469

Anahtar Kelimeler : Mediterranean diet score, Western diet, cervical intraepithelial neoplasia, principal component analysis, prudent diet

Sınıflandırma :

Tıp ve Halk Sağlığı %68

Kanser Araştırmaları %99

Biyotıp %32

Epidemiyoloji %100

13

Response to Comments on Montagna et al. “Evaluation of Legionella Air Contamination in Healthcare Facilities by Different Sampling Methods: An Italian Multicenter Study” Int. J. Environ. Res. Public Health 2017, 14, 670

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Environmental Research and Public Health

Yazar(lar) :

Maria Teresa Montagna , Osvalda De Giglio , Antonella Agodi , Cesira Pasquarella

Yıl :

2017

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

We would like to thank Collins andWalker for their comments and for acknowledging that this is an area requiring more research to improve our basic understanding of Legionella [1]. [...]

DOI : 10.3390/ijerph14080906

Cilt: 14
Sayı: 8
Sayfa: 906

Sınıflandırma :

Felsefe %24

İş Ahlakı %41

Çevre %22

Su kirliliği %98

14

The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

Hindawi Limited

Dergi:

International Journal of Genomics

Yazar(lar) :

Martina Barchitta , Andrea Maugeri , Annalisa Quattrocchi , Ottavia Agrifoglio , Antonella Agodi

Yıl :

2017

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.

Kaynak 1:

https://doi.org/10.1155/2017/8067972 arayıcılığı görüntüle.
Kaynak 2:

https://www.hindawi.com/journals/ijg/2017/8067972/ arayıcılığı görüntüle.

DOI : 10.1155/2017/8067972

Cilt: 2017

Sınıflandırma :

Biyotıp %93

İnsan Genetiği %37

Epidemiyoloji %22

15

LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis.

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

PLoS ONE

Yazar(lar) :

Martina Barchitta , Annalisa Quattrocchi , Andrea Maugeri , Manlio Vinciguerra , Antonella Agodi

Yıl :

2014

Antonella Agodi

Özet Ek Bilgiler

Kaydet

A systematic review and a meta-analysis were carried out in order to summarize the current published studies and to evaluate LINE-1 hypomethylation in blood and other tissues as an epigenetic marker for cancer risk.A systematic literature search in the Medline database, using PubMed, was conducted for epidemiological studies, published before March 2014. The random-effects model was used to estimate weighted mean differences (MDs) with 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by sample type (tissue or blood samples), cancer types, and by assays used to measure global DNA methylation levels. The Cochrane software package Review Manager 5.2 was used.A total of 19 unique articles on 6107 samples (2554 from cancer patients and 3553 control samples) were included in the meta-analysis. LINE-1 methylation levels were significantly lower in cancer patients than in controls (MD: -6.40, 95% CI: -7.71, -5.09; p<0.001). The significant difference in methylation levels was confirmed in tissue samples (MD -7.55; 95% CI: -9.14, -65.95; p<0.001), but not in blood samples (MD: -0.26, 95% CI: -0.69, 0.17; p = 0.23). LINE-1 methylation levels were significantly lower in colorectal and gastric cancer patients than in controls (MD: -8.33; 95% CI: -10.56, -6.10; p<0.001 and MD: -5.75; 95% CI: -7.75, -3.74; p<0.001) whereas, no significant difference was observed for hepatocellular cancer.The present meta-analysis adds new evidence to the growing literature on the role of LINE-1 hypomethylation in human cancer and demonstrates that LINE-1 methylation levels were significantly lower in cancer patients than in control samples, especially in certain cancer types. This result was confirmed in tissue samples, both fresh/frozen or FFPE specimens, but not in blood. Further studies are needed to better clarify the role of LINE-1 methylation in specific subgroups, considering both cancer and sample type, and the methods of measurement.

DOI : 10.1371/journal.pone.0109478

ISSN: 1932-6203
Cilt: 9
Sayı: 10
Sayfa: e109478

16

Epigenetic Biomarkers in Colorectal Cancer Patients Receiving Adjuvant or Neoadjuvant Therapy: A Systematic Review of Epidemiological Studies

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Molecular Sciences

Yazar(lar) :

Martina Barchitta , Andrea Maugeri , Giovanni Li Destri , Guido Basile , Antonella Agodi

Yıl :

2019

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Colorectal cancer (CRC) represents the third-most common cancer worldwide and one of the main challenges for public health. Despite great strides in the application of neoadjuvant and adjuvant therapies for rectal and colon cancer patients, each of these treatments is still associated with certain adverse effects and different response rates. Thus, there is an urgent need for identifying novel potential biomarkers that might guide personalized treatments for specific subgroups of patients. However, until now, there are no biomarkers to predict the manifestation of adverse effects and the response to treatment in CRC patients. Herein, we provide a systematic review of epidemiological studies investigating epigenetic biomarkers in CRC patients receiving neoadjuvant or adjuvant therapy, and their potential role for the prediction of outcomes and response to treatment. With this aim in mind, we identified several epigenetic markers in CRC patients who received surgery with adjuvant or neoadjuvant therapy. However, none of them currently has the robustness to be translated into the clinical setting. Thus, more efforts and further large-size prospective studies and/or trials should be encouraged to develop epigenetic biomarker panels for personalized prevention and medicine in CRC cancer.

DOI : 10.3390/ijms20153842

Anahtar Kelimeler : DNA methylation, miRNA, prevention, Public Health, Epidemiology, colon cancer, rectal cancer

Cilt: 20
Sayı: 15
Sayfa: 3842

Sınıflandırma :

Biyotıp %57

Tropik ilaç %42

Biyotıp %31

Tıp ve Halk Sağlığı %43

Onkoloji %55

Kanser Araştırmaları %30

17

Comparison of aspiration with sclerotherapy and laparoscopic deroofing for the treatment of symptomatic simple renal cysts: a systematic review and meta-analysis

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Updates in Surgery

Yazar(lar) :

Andrea Maugeri , Gabriele Fanciulli , Martina Barchitta , Antonella Agodi , Guido Basile

Konu :

Surgery

Yıl :

2021

Antonella Agodi

Özet Ek Bilgiler

Kaydet

There are currently several strategies for the treatment of symptomatic simple renal cysts, such as aspiration with sclerosants and laparoscopic deroofing. However, no clear indication exists for choosing between them. Here, we carried out a systematic review and a meta-analysis of studies, which compared symptomatic and radiological success between aspiration with sclerotherapy and laparoscopic deroofing. Results were reported as relative risk (RR) and 95% confidence interval (95% CI) using laparoscopic deroofing as control group. The symptomatic and radiological successes were evaluated by 6 and 3 studies, respectively. Notably, aspiration with sclerotherapy was associated with higher risk of failure than laparoscopic deroofing (RR = 2.82; 95% CI = 1.84–4.31 for symptomatic failure; RR = 8.31; 95% CI = 4.22–16.38 for radiological failure). On the other hand, however, aspiration with sclerotherapy was associated with less frequent complications, shorter treatment duration and post-treatment hospital stay, and lower costs. Thus, our work underlines benefits and drawbacks of each intervention, raising the need for further studies to design guidelines for the management of simple renal cysts.

DOI : 10.1007/s13304-021-01042-2

Anahtar Kelimeler : Renal cysts, Percutaneous aspiration, Sclerotherapy, Laparoscopic deroofing, Marsupialization

ISSN: 2038-131X 2038-3312
Sayı: 5
Cilt: 73
Sayfa: 1691-1698

18

Tumor Necrosis Factor-Alpha −308 G>A Polymorphism, Adherence to Mediterranean Diet, and Risk of Overweight/Obesity in Young Women

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

BioMed Research International

Yazar(lar) :

Martina Barchitta , Annalisa Quattrocchi , Veronica Adornetto , Anna Elisa Marchese , Antonella Agodi

Yıl :

2014

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The present study was conducted in order to (i) characterize the adherence to the Mediterranean diet (MD) pattern and fatty acids (FAs) intakes and (ii) explore interactions between TNFA −308 G>A polymorphism and adherence to MD and FAs intakes, respectively, on overweight/obesity risk. From 2010 to 2013, 380 healthy women were enrolled, and MD score (MDS) and FAs intakes were evaluated by a Food Frequencies Questionnaire in relation to nutritional status. TNFA −308 G/A polymorphism was characterized using PCR-RFLP. A total of 32.6% of women were overweight or obese. Lower mean MDS values were more observed in the younger age group than in the older age group (3.60 versus 4.45). The risk of being overweight/obese was 3.5-fold increased due to poor adherence to MD and was about twofold increased in less educated women. Furthermore, younger age was associated with poor adherence to MD. No evidence for an independent effect of the polymorphism on overweight/obesity risk was found. There was no evidence of biological interaction from the gene-diet interaction analyses. Young women, less educated and with poor adherence to MD, are a target group for the nutritional interventions that aimed to control the obesity risk, thus improving the adherence to MD and particularly the intake of unsaturated FAs.

DOI : 10.1155/2014/742620

Cilt: 2014

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Klinik Beslenme %92

19

Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Int J Mol Sci

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Maria Grazia Mazzone , Francesco Giuliano , Guido Basile , Antonella Agodi

Konu :

Cell Line, Cell Survival, DNA (Cytosine-5-)-Methyltransferases, Epigenomics, Glucose Oxidase, Humans, Inflammation, Lipopolysaccharides, Long Interspersed Nucleotide Elements, Methylation, Oxidative Stress, Resveratrol, Sirtuin 1, Stilbenes

Yıl :

2018

Antonella Agodi

Piri Tam Metin Bulucu Özet

Kaydet

The role of epigenetic alterations in the pathogenesis of retinal degenerative diseases, including age-related macular degeneration (AMD), has been pending so far. Our study investigated the effect of oxidative stress and inflammation on DNA methyltransferases (DNMTs) and Sirtuin 1 (SIRT1) functions, as well as on long interspersed nuclear element-1 (LINE-1) methylation, in human retinal pigment epithelial (ARPE-19) cells. Therefore, we evaluated whether treatment with resveratrol may modulate DNMT and SIRT1 functions and restore changes in LINE-1 methylation. Cells were treated with 25 mU/mL glucose oxidase (GOx) or 10 µg/mL lipopolysaccharide (LPS) to mimic oxidative or inflammatory conditions, respectively. Oxidative stress decreased DNMT1, DNMT3a, DNMT3b, and SIRT1 expression (p-values < 0.05), as well as total DNMTs (-28.5%; p < 0.0001) and SIRT1 (-29.0%; p < 0.0001) activities. Similarly, inflammatory condition decreased DNMT1 and SIRT1 expression (p-values < 0.05), as well as total DNMTs (-14.9%; p = 0.007) and SIRT1 (-20.1%; p < 0.002) activities. Interestingly, GOx- and LPS-treated cells exhibited lower LINE-1 methylation compared to controls (p-values < 0.001). We also demonstrated that treatment with 10 μM resveratrol for 24 h counteracted the detrimental effect on DNMT and SIRT1 functions, and LINE-1 methylation, in cells under oxidative and inflammatory conditions. However, further studies should explore the perspectives of resveratrol as a suitable strategy for the prevention and/or treatment of retinal degenerative diseases.

DOI : 10.3390/ijms19072118

Anahtar Kelimeler : DNA methylation, epigenetics, inflammation, oxidative stress, retinal degeneration

20

Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Oxid Med Cell Longev

Yazar(lar) :

Andrea Maugeri , Maria Grazia Mazzone , Francesco Giuliano , Manlio Vinciguerra , Guido Basile , Martina Barchitta , Antonella Agodi

Konu :

Animals, Cell Line, Cell Survival, Curcumin, DNA-Cytosine Methylases, Diabetes Mellitus, Experimental, Diabetic Retinopathy, Humans, Oxidative Stress, Reactive Oxygen Species

Yıl :

2018

Antonella Agodi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Hyperglycaemia-induced oxidative stress appears to be involved in the aetiology of diabetic retinopathy (DR), a major public health issue, via altering DNA methylation process. We investigated the effect of hyperglycaemia on retinal DNA methyltransferase (DNMT) expression in diabetic mice, using Gene Expression Omnibus datasets. We also evaluated the effect of curcumin both on high glucose-induced reactive oxygen species (ROS) production and altered DNMT functions, in a cellular model of DR. We observed that three months of hyperglycaemia, in insulin-deficient Ins2 Akita mice, decrease DNMT1 and DNMT3a expression levels. In retinal pigment epithelium (RPE) cells, we also demonstrated that high glucose-induced ROS production precedes upregulation of DNMT expression and activity, suggesting that changes in DNMT function could be mediated by oxidative stress via a potential dual effect. The early effect results in decreased DNMT activity, accompanied by the highest ROS production, while long-term oxidative stress increases DNMT activity and DNMT1 expression. Interestingly, treatment with 25 μM curcumin for 6 hours restores ROS production, as well as DNMT functions, altered by the exposure of RPE to acute and chronic high glucose concentration. Our study suggests that curcumin may represent an effective antioxidant compound against DR, via restoring oxidative stress and DNMT functions, though further studies are recommended.

DOI : 10.1155/2018/5407482

Sınıflandırma :

Biyotıp %100

Hücre Biyolojisi %97

21

Characterization of SIRT1/DNMTs Functions and LINE-1 Methylation in Patients with Age-Related Macular Degeneration

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Clinical Medicine

Yazar(lar) :

Andrea Maugeri , Martina Barchitta , Matteo Fallico , Niccolò Castellino , Michele Reibaldi , Antonella Agodi

Yıl :

2019

Antonella Agodi