Piri Keşif Aracı

Kaynak 1: https://doi.org/10.1155/2008/416910 arayıcılığı görüntüle.
Kaynak 2: https://www.hindawi.com/journals/jir/2008/416910/ arayıcılığı görüntüle.

DOI : 10.1155/2008/416910

Cilt: 2008

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %62

2

Homeostatic and pathogenic extramedullary hematopoiesis

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Blood Medicine

Yazar(lar) :

Chang H Kim

Yıl :

2010

Chang H Kim

Özet Ek Bilgiler

Chang H KimLaboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology; Purdue Cancer Center, Purdue University, West Lafayette, IN, USAAbstract: Extramedullary hematopoiesis (EH) is defined as hematopoiesis occurring in organs outside of the bone marrow; it occurs in diverse conditions, including fetal development, normal immune responses, and pathological circumstances. During fetal development, before formation of mature marrow, EH occurs in the yolk sac, fetal liver, and spleen. EH also occurs during active immune responses to pathogens. Most frequently, this response occurs in the spleen and liver for the production of antigen-presenting cells and phagocytes. EH also occurs when the marrow becomes inhabitable for stem and progenitor cells in certain pathological conditions, including myelofibrosis, where marrow cells are replaced with collagenous connective tissue fibers. Thus, EH occurs either actively or passively in response to diverse changes in the hematopoietic environment. This article reviews the key features and regulators of the major types of EH.Keywords: myelopoiesis, cytokines, myeloid derived suppressor cells, T cells, infection, dendritic cells, FoxP3, myelofibrosis

ISSN: 1179-2736
Cilt: 2010
Sayı: default
Sayfa: 13 - 19

Sınıflandırma :

Biyotıp %100

Hematoloji %98

3

Host and microbial factors in regulation of T cells in the intestine

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Immunology

Yazar(lar) :

Chang H Kim

Yıl :

2013

Chang H Kim

Piri Tam Metin Bulucu Özet Ek Bilgiler

The intestine is divided into specialized tissue areas that provide distinct microenvironments for T cells. Regulation of T cell responses in the gut has been a major focus of recent research activities in the field. T cells in the intestine are regulated by the interplay between host and microbial factors. In the small intestine, retinoic acid (RA) is a major tissue factor that plays important roles in regulation of immune responses. In the large intestine, the influence of RA diminishes, but that of commensal bacterial products increases. RA, gut microbiota, and inflammatory mediators co-regulate differentiation, distribution, and/or effector functions of T cells. Coordinated regulation of immune responses by these factors promotes well-balanced immunity and immune tolerance. Dysregulation of this process can increase infection and inflammatory diseases.

DOI : 10.3389/fimmu.2013.00141

Anahtar Kelimeler : Dendritic Cells, T cells, Foxp3, intestine, Retinoic acid

ISSN: 1664-3224
Cilt: 4

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %53

4

B cell-helping functions of gut microbial metabolites

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Microbial Cell

Yazar(lar) :

Chang H. Kim

Yıl :

2016

Chang H. Kim

Piri Tam Metin Bulucu Özet Ek Bilgiler

Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article.

DOI : 10.15698/mic2016.10.536

Anahtar Kelimeler : commensal bacteria, dietary fiber, short-chain fatty acids, acetate, propionate, butyrate, B cells, antibodies, immunity

ISSN: 2311-2638
Cilt: 3
Sayı: 10
Sayfa: 529 - 531

5

FOXP3 and Its Role in the Immune System

e-Kitap

Kaynak :

Springer Link

Dergi:

Forkhead Transcription Factors

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Kim

Yıl :

2009

Chang H. Kim

Özet Ek Bilgiler

FOXP3 is a member of the forkhead transcription factor family. Unlike other members, it is mainly expressed in a subset ofCD4+ T-cells that play a suppressive role in the immune system. A function of FOXP3 is to suppress the function of NFAT and NFKB and this leads to suppression of expression of many genes including IL-2 and effector T-cell cytokines. FOXP3 acts also as a transcription activator for many genes including CD25, Cytotoxic T-Lymphocyte Antigen4 (CTLA4), glucocorticoid-induced TNF receptor family gene (GITR) and folate receptor 4. FOXP3+ T-cells are made in the thymus and periphery. The FOXP3+ T-cells made in the thymus migrate to secondary lymphoid tissues and suppress antigen priming of lymphocytes. Antigen priming of naïve FOXP3+ T-cells and naïve FOXP3− T-cells leads to generation of memory FOXP3+ T-cells which are efficient in migration to nonlymphoid tissues. Memory FOXP3+ T-cells are, therefore, effective in suppression of effector T-cell function, while naive FOXP3+ T-cells are adept at suppressing the early immune responses in lymphoid tissues. Both naïve and memory FOXP3+ T-cells are required for effective maintenance of tolerance and prevention of autoimmune diseases throughout the body. Many factors such as cytokines and noncytokine factors regulate the generation of FOXP3+ T-cells. For example, retinoic acid, produced by the dendritic cells and epithelial cells in the intestine, works together with TGF-β1 and promotes generation of small intestine-homing FOXP3+ T-cells by upregulating the expression of FOXP3 and gut homing receptors. FOXP3+ T-cells can be produced in vitro from autologous naïve T-cells and, therefore, have great therapeutic potentials in treating a number of inflammatory diseases and graft rejection.

DOI : 10.1007/978-1-4419-1599-3_2

Anahtar Kelimeler : Retinoic Acid, Experimental Autoimmune Encephalomyelitis, Foxp3 Expression, Forkhead Transcription Factor, FOXP3 Gene

ISBN: 978-1-4419-1599-3
Sayfa: 17-29

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %32

6

Regulatory T Cells and Th17 Cells in Cancer Microenvironment

e-Kitap

Kaynak :

Springer Link

Dergi:

Cancer Immunology

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Kim

Yıl :

2015

Chang H. Kim

Özet Ek Bilgiler

It is widely believed that tumors maintain highly tolerogenic environments to suppress antitumor immune responses. This perspective on tumor microenvironments appears to be largely true, but an increasing body of evidence suggests that certain types of cancer are formed in inflammatory conditions and tumors produce a number of inflammatory mediators. The tolerogenic nature of the tumor microenvironment is reflected in the presence of a large number of immunosuppressive FoxP3+ T cells in tumors and draining lymph nodes. Th17 cells, formed in inflammatory conditions, are variably present in many types of tumors. Both FoxP3+ T cells and Th17 cells can regulate antitumor immune responses in positive and negative ways. Tumor microenvironments and cancer types significantly affect the numbers and functions of the two T-cell subsets in tumors. Tumor microenvironments that regulate migration and population of FoxP3+ T cells and Th17 cells in tumors and associated lymphoid tissues are discussed in this chapter.

DOI : 10.1007/978-3-662-44006-3_6

Anahtar Kelimeler : Retinoic Acid, Th17 Cell, Tumor Microenvironment, Antitumor Immune Response, Tumor Environment

ISBN: 978-3-662-44006-3
Sayfa: 77-91

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %89

7

Phonological Activation in Multi-syllabic Sord Recognition

Dergi Makalesi

Kaynak 1:

Springer Link

Kaynak 2:

Springer Link

Dergi:

Journal of Psycholinguistic Research

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Lee

Konu :

Psychology, Cognitive Psychology, Psycholinguistics

Yıl :

2006

Chang H. Lee

Yayıncı Web Siteleri

Özet Ek Bilgiler

Three experiments were conducted to test the phonological recoding hypothesis in visual word recognition. Most studies on this issue have been conducted using mono-syllabic words, eventually constructing various models of phonological processing. Yet in many languages including English, the majority of words are multi-syllabic words. English includes words incorporating a silent letter in their letter strings (e.g., champa

$$\underline{{\rm g}}$$
ne). Such words provide an opportunity for investigating the role of phonological information in multi-syllabic words by comparing them to words that do not have the silent letter in the corresponding position (e.g., passen

$$\underline{{\rm g}}$$
er). The performance focus is on the effects of removing letters from words with a silent letter and from words with a non-silent letter. Three representative lexical tasks—naming, semantic categorization, lexical decision—were conducted in the present study. Stimuli that excluded a silent letter (e.g., champa_ne) were processed faster than those that excluded a sounding letter (e.g., passen_er) in the naming (Experiment 1), the semantic categorization (Experiment 2), and the lexical decision task (Experiment 3). The convergent evidence from these three experiments provides seminal proof of phonological recoding in multi-syllabic word recognition.

Kaynak 1: https://link.springer.com/article/10.1007/s10936-006-9029-4 arayıcılığı görüntüle.
Kaynak 2: https://link.springer.com/article/10.1007/s10936-006-9039-2 arayıcılığı görüntüle.

DOI : 10.1007/s10936-006-9029-4

Anahtar Kelimeler : Word recognition, Multi-syllabic word, Phonological recoding, Silent letter

ISSN: 1573-6555
Cilt: 36
Sayı: 1
Sayfa: 1-14

Sınıflandırma :

Dilbilim %94

Dilbilim %76

Dil ve Edebiyat %21

8

Trafficking Receptors and Migration of TH17 Cell Subsets

Kitap Bölümü

Kaynak :

Springer Link

Dergi:

TH17 Cells in Health and Disease

Yayıncı:

Springer New York

Yazar(lar) :

Chang H. Kim

Yıl :

2011

Chang H. Kim

Ek Bilgiler

DOI : 10.1007/978-1-4419-9371-7_10

Sayfa: 203-216

9

Regulatory T-Cells and Th17 Cells in Tumor Microenvironment

e-Kitap

Kaynak :

Springer Link

Dergi:

Cancer Immunology

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Kim

Yıl :

2020

Chang H. Kim

Özet Ek Bilgiler

It is widely believed that tumors maintain highly tolerogenic environments to suppress anti-tumor immune responses. The perspective on tumor microenvironments appears to be largely true, but an increasing body of evidence suggests that certain types of cancer are formed in inflammatory conditions and tumors produce a number of inflammatory mediators. The tolerogenic nature of the tumor microenvironment is reflected in the presence of a large number of immunosuppressive FoxP3+ T-cells in tumors and draining lymph nodes. Th17 cells, formed in inflammatory conditions, are variably present in many types of tumors. Both FoxP3+ T-cells and Th17 cells can regulate anti-tumor immune responses in positive and negative ways. Tumor microenvironments and cancer types significantly affect the numbers and functions of the two T-cell subsets in tumors. Tumor microenvironments that regulate the population and function of FoxP3+ T-cells and Th17 cells in tumors are discussed in this article.

DOI : 10.1007/978-3-030-30845-2_6

Anahtar Kelimeler : FoxP3+ T-cells, Th17 cells, Tumor microenvironment

ISBN: 978-3-030-30845-2
Sayfa: 91-106

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %89

10

Retinoic Acid, Immunity, and Inflammation

Kitap Bölümü

Kaynak :

Science Direct

Dergi:

Vitamins and the Immune System

Yayıncı:

Elsevier

Yazar(lar) :

Chang H. Kim

Yıl :

2011

Chang H. Kim

Ek Bilgiler

DOI : 10.1016/b978-0-12-386960-9.00004-6

ISSN: 0083-6729
ISBN:9780123869609
Sayfa: 83-101

Sınıflandırma :

Biyotıp %100

Gen İfadesi %84

11

Microbiota or short-chain fatty acids: which regulates diabetes?

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Cellular & Molecular Immunology

Yayıncı:

Springer Nature

Yazar(lar) :

Chang H Kim

Konu :

Biomedicine, general, Immunology, Medical Microbiology, Microbiology, Antibodies, Vaccine

Yıl :

2017

Chang H Kim

Ek Bilgiler

DOI : 10.1038/cmi.2017.57

ISSN: 2042-0226
Cilt: 15
Sayı: 2
Sayfa: 88-91

12

Crawling of effector T cells on extracellular matrix: role of integrins in interstitial migration in inflamed tissues

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Cellular & Molecular Immunology

Yayıncı:

Springer Nature

Yazar(lar) :

Chang H Kim

Konu :

Biomedicine, general, Immunology, Medical Microbiology, Microbiology, Antibodies, Vaccine

Yıl :

2013

Chang H Kim

Ek Bilgiler

DOI : 10.1038/cmi.2013.47

ISSN: 2042-0226
Cilt: 11
Sayı: 1
Sayfa: 1-4

13

Chemokines and Their Receptors in Hematopoietic Cell Development and Functioning

Kitap Bölümü

Kaynak :

Science Direct

Dergi:

Chemokines, Chemokine Receptors, and Disease

Yayıncı:

Elsevier

Yazar(lar) :

Chang H. Kim

Yıl :

2005

Chang H. Kim

Ek Bilgiler

DOI : 10.1016/s1063-5823(04)55005-6

ISSN: 1063-5823
ISBN:9780121533557
Sayfa: 115-142

Sınıflandırma :

Biyotıp %100

Reseptörler %86

14

Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Experimental Hematology

Yayıncı:

Elsevier

Yazar(lar) :

Chang H. Kim

Yıl :

2006

Chang H. Kim

Ek Bilgiler

DOI : 10.1016/j.exphem.2006.03.014

ISSN: 0301-472X
Sayı: 8
Cilt: 34
Sayfa: 1033-1040

Sınıflandırma :

Biyotıp %88

Hematoloji %64

15

Trafficking of FoxP3 + regulatory T cells: myths and facts

Derleme Makalesi

Kaynak :

Springer Link

Dergi:

Archivum Immunologiae et Therapiae Experimentalis

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Kim

Konu :

Immunology, Pharmacology

Yıl :

2007

Chang H. Kim

Özet Ek Bilgiler

Fork head box P3 (FoxP3+) regulatory T cells (Tregs) are specialized T cells for prevention of hyperimmune responses and autoimmunity. Tumors and pathogens can hijack FoxP3+ Tregs to evade host immune responses. There is an increasing body of evidence that trafficking of FoxP3+ Tregs is important for their effective suppression of target cells. Because of their distinctive functions and gene expression phenotype, the migratory behavior of FoxP3+ Tregs has been somewhat mystified. The myths are that they have unique trafficking receptors and migratory behaviors that are different from those of conventional T cells. Another related myth is that FoxP3+ regulatory T cell subsets have a fixed trafficking behavior from the time they are generated in the thymus. The recent progress in trafficking receptors and migratory behavior of FoxP3+ Tregs is reviewed here and the validity of these myths is examined.

DOI : 10.1007/s00005-007-0024-8

Anahtar Kelimeler : FoxP3, regulatory T cells, migration, chemokine receptor, integrin, selectin

ISSN: 1661-4917
Cilt: 55
Sayı: 3
Sayfa: 151-159

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %71

16

Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis

Kitap Bölümü

Kaynak :

Springer Link

Dergi:

The Receptors

Yayıncı:

Humana Press

Yazar(lar) :

Chang H. Kim

Yıl :

2007

Chang H. Kim

Ek Bilgiler

DOI : 10.1007/978-1-59745-020-1_8

Sayfa: 119-138

17

Adaptive Changes in Grain-size in Morphological Processing

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Psycholinguistic Research

Yayıncı:

Springer Link

Yazar(lar) :

Chang H. Lee

Konu :

Psychology, Cognitive Psychology, Psycholinguistics

Yıl :

2007

Chang H. Lee

Özet Ek Bilgiler

Substantial neurobiological data indicate that the dominant cortical region for printed-word recognition shifts from a temporo-parietal (dorsal) to an occipito-temporal (ventral) locus with increasing recognition experience. The circuits also have different characteristic speeds of response and word preferences. Previous evidence suggested that grain-size increased with word repetition. In the present experiment, we examined morpheme boundaries imposing a limitation on steadily increasing grain-size within a word. We manipulated the type font within a word so that it either emphasized or disguised the word’s morphemic structure. The results showed that, even after several repetitions, morphemic structure had an effect on word recognition, although eventually it did become nonsignificant. Thus, the spread of grain-size with repetition does not appear to cross morpheme boundaries easily. These results suggest that skilled, experienced, word recognition may achieve its speed, substantially, by unitizing the word’s letters within but not across its morphological units.

DOI : 10.1007/s10936-007-9059-6

Anahtar Kelimeler : Word learning, Grainsize, Morphological processing, Repetition, Mixed case

ISSN: 1573-6555
Cilt: 37
Sayı: 1
Sayfa: 59-67

Sınıflandırma :

Dilbilim %72

Fonoloji ve Fonetik %70

Psikoloji %27

Psikodilbilim %100

18

A LOCUS OF THE WORD-LENGTH EFFECT ON WORD RECOGNITION

Dergi Makalesi

Kaynak :

Taylor and Francis

Dergi:

Reading Psychology

Yayıncı:

Informa UK Limited

Yazar(lar) :

Chang H. Lee

Yıl :

1999

Chang H. Lee

Ek Bilgiler

DOI : 10.1080/027027199278448

ISSN: 0270-2711
Sayı: 2
Cilt: 20
Sayfa: 129-150

19

Immune regulation by microbiome metabolites.

Dergi Makalesi

Kaynak 1:

PubMed

Kaynak 2:

Wiley Online Library

Dergi:

Immunology

Yazar(lar) :

Chang H Kim

Yıl :

2018

Chang H Kim

Yayıncı Web Siteleri

Piri Tam Metin Bulucu Özet Ek Bilgiler

Commensal microbes and the host immune system have been co-evolved for mutual regulation. Microbes regulate the host immune system, in part, by producing metabolites. A mounting body of evidence indicates that diverse microbial metabolites profoundly regulate the immune system via host receptors and other target molecules. Immune cells express metabolite-specific receptors such as P2X7 , GPR41, GPR43, GPR109A, aryl hydrocarbon receptor precursor (AhR), pregnane X receptor (PXR), farnesoid X receptor (FXR), TGR5 and other molecular targets. Microbial metabolites and their receptors form an extensive array of signals to respond to changes in nutrition, health and immunological status. As a consequence, microbial metabolite signals contribute to nutrient harvest from diet, and regulate host metabolism and the immune system. Importantly, microbial metabolites bidirectionally function to promote both tolerance and immunity to effectively fight infection without developing inflammatory diseases. In pathogenic conditions, adverse effects of microbial metabolites have been observed as well. Key immune-regulatory functions of the metabolites, generated from carbohydrates, proteins and bile acids, are reviewed in this article.

Kaynak 1: https://www.ncbi.nlm.nih.gov/pubmed/10947158 arayıcılığı görüntüle.
Kaynak 2: https://onlinelibrary.wiley.com/doi/10.1111/imm.12930 arayıcılığı görüntüle.

DOI : 10.1111/imm.12930

Anahtar Kelimeler : barrier function, bile acids, immunity, indole, inflammation, metabolites, microbiome, short-chain fatty acids

Sınıflandırma :

Biyotıp %100

Reseptörler %83

20

Reining in FoxP3 + regulatory T cells by the sphingosine 1‐phosphate‐S1P1 axis

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Immunology & Cell Biology

Yazar(lar) :

Chang H Kim

Konu :

Immunology, Cell Biology

Yıl :

2009

Chang H Kim

Ek Bilgiler

DOI : 10.1038/icb.2009.49

ISSN: 0818-9641
Sayı: 7
Cilt: 87
Sayfa: 502-504

21

The effect of different water managements on rice arsenic content in two arsenic-spiked soils

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

E3S Web of Conferences

Yazar(lar) :

Chang H. Y. , Chen Z. S.

Yıl :

2013

Chang H. Y.

Piri Tam Metin Bulucu Özet Ek Bilgiler

Growing rice on arsenic (As)-contaminated paddy fields may induce high As level grain production. In order to reduce the food contamination risk, the pot experiments containing two As-spiked aging soils and four water managements were conducted to evaluate the effects of water managements on rice As content. The results indicated that As concentration of Erlin soil solution was 10 to 20 times (210-520 μg/L) higher than that of Pinchen soil solution (5-20 μg/L) at early stage of experiment (0-60 days). Aerobic water treatment will decrease As level to 30-50% (108-220 μg/L) of original As concentration in Erlin soil solution. Statistic results indicated that water management was effective to reduce the rice grain As level in Erlin soil. However, the management impact was not obvious in Pinchen soil, which may be attributed to high clay or free Fe and Al content in the soil. This study suggested that keeping soil under aerobic condition for 3 weeks before rice heading can reduce the risk of rice grown at the As-contamination soil.

DOI : 10.1051/e3sconf/20130115007

Anahtar Kelimeler : arsenic contamination, water management, rice grain, aerobic condition, soil solution

ISSN: 2267-1242
Cilt: 1
Sayfa: 15007

Sınıflandırma :

Çevre %100

Su kirliliği %47

Çevresel Sağlık %26

22

A formal model for behavioral test generation

Tez

Kaynak :

NDTLD Thesis

Dergi:

Global ETD Search

Yayıncı:

Global ETD Search

Yazar(lar) :

Chang H. Cho

Yıl :

1994

Chang H. Cho

Özet Ek Bilgiler

Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1994. / Vita. Abstract. Includes bibliographical references (leaves 159-163). Also available via the Internet.

Anahtar Kelimeler : Integrated circuits

Sınıflandırma :

Bilgisayar Bilimi %20

Bilgi İşlem Tarihi %73

23

Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Cellular & Molecular Immunology

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Chang H. KimChang H. Kim

Yıl :

2021

Chang H. KimChang H. Kim

Özet Ek Bilgiler

AbstractA mounting body of evidence indicates that dietary fiber (DF) metabolites produced by commensal bacteria play essential roles in balancing the immune system. DF, considered nonessential nutrients in the past, is now considered to be necessary to maintain adequate levels of immunity and suppress inflammatory and allergic responses. Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are the major DF metabolites and mostly produced by specialized commensal bacteria that are capable of breaking down DF into simpler saccharides and further metabolizing the saccharides into SCFAs. SCFAs act on many cell types to regulate a number of important biological processes, including host metabolism, intestinal functions, and immunity system. This review specifically highlights the regulatory functions of DF and SCFAs in the immune system with a focus on major innate and adaptive lymphocytes. Current information regarding how SCFAs regulate innate lymphoid cells, T helper cells, cytotoxic T cells, and B cells and how these functions impact immunity, inflammation, and allergic responses are discussed.

DOI : 10.1038/s41423-020-00625-0

ISSN: 1672-7681
Sayı: 5
Cilt: 18
Sayfa: 1161-1171

24

Periarteriolar stroma cells guide T cells from the red to the white pulp in the spleen

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Cellular & Molecular Immunology

Yayıncı:

Springer Nature

Yazar(lar) :

Chang H. Kim , Qingyang Liu

Konu :

CD4-positive T cells, Chemokines

Yıl :

2020

Chang H. Kim

Özet Ek Bilgiler

While both the spleen and lymph nodes are called secondary lymphoid tissues, how lymphocytes enter these tissues are quite different from each other. This is because the architecture of the two types of organs and the mode of lymphocyte migration into these organs are quite distinct. In the spleen, T cells are passively released in the blood flow from the arterioles in the red pulp and marginal zone area. In contrast, T cells in the blood are actively captured on high endothelial venules in lymph nodes by the coordinated actions of CCR7 and several adhesion molecules. A recent finding indicates that T cells, released in the red pulp and marginal zone areas, actively find their way to the white zone by utilizing the migration track created by periarteriolar stromal cells. This finding adds one more piece to our understanding of lymphocyte migration for effective adaptive immune responses in the spleen.

DOI : 10.1038/s41423-020-0506-8

ISSN: 2042-0226
Sayfa: 1-3

25

Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

BMC Immunology

Yazar(lar) :

Hillsamer Peter , Kim Chang H , Wang Chuanwu

Yıl :

2011

Kim Chang H

Piri Tam Metin Bulucu Özet Ek Bilgiler

Abstract Background It is well established that PD-1 is expressed by follicular T cells but its function in regulation of human T helper cells has been unclear. We investigated the expression modality and function of PD-1 expressed by human T cells specialized in helping B cells. Results We found that PD-1-expressing T cells are heterogeneous in PD-1 expression. We identified three different PD-1-expressing memory T cell subsets (i.e. PD-1low (+), PD-1medium (++), and PD-1high (+++) cells). PD-1+++ T cells expressed CXCR5 and CXCR4 and were localized in the rim of germinal centers. PD-1+ or PD-1++ cells expressed CCR7 and were present mainly in the T cell area or other parts of the B cell follicles. Utilizing a novel antigen density-dependent magnetic sorting (ADD-MS) method, we isolated the three T cell subsets for functional characterization. The germinal center-located PD-1+++ T cells were most efficient in helping B cells and in producing IL-21 and CXCL13. Other PD-1-expressing T cells, enriched with Th1 and Th17 cells, were less efficient than PD-1+++ T cells in these capacities. PD-1+++ T cells highly expressed Ki-67 and therefore appear active in cell activation and proliferation in vivo. IL-2 is a cytokine important for proliferation and survival of the PD-1+++ T cells. In contrast, IL-21, while a major effector cytokine produced by the PD-1-expressing T helper cells, had no function in generation, survival, or proliferation of the PD-1-expressing helper T cells at least in vitro. PD-1 triggering has a suppressive effect on the proliferation and B cell-helping function of PD-1+++ germinal center T cells. Conclusion Our results revealed the phenotype and effector function of PD-1-expressing T helper cell subsets and indicate that PD-1 restrains the B cell-helping function of germinal center-localized T cells to prevent excessive antibody response.

DOI : 10.1186/1471-2172-12-53

ISSN: 1471-2172
Cilt: 12
Sayı: 1
Sayfa: 53

Sınıflandırma :

Biyotıp %100

Hücre Biyolojisi %25

Hematoloji %22

26

Tidal Interaction as the origin of early-type dwarf galaxies in group environment

Araştırma Makalesi

Kaynak :

arXiv

Yazar(lar) :

Sanjaya Paudel , Chang H. Ree

Konu :

Astrophysics of Galaxies

Yıl :

2014

Chang H. Ree

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