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1
The investigation of adsorption at metal-oil interfaces by means of surface potential measurements
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Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift
Yazar(lar) :
D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1961
D. A. Haydon
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DOI : 10.1007/bf01520597
Anahtar Kelimeler : Polymer, Physical Chemistry, Potential Measurement, Surface Potential Measurement
ISSN: 0303-402X 1435-1536
Sayı: 1
Cilt: 179
Sayfa: 72-73
2
Boundary potentials and adsorption at the oil-metal interface
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1963
D. A. Haydon
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The adsorption of a number of different molecules at the interfaces between oxidized metals and aliphatic hydrocarbons has been examined by the measurement of changes in contact potential. The plots of the potentials against solute concentration closely resemble adSorption isotherms, and it has been shown that by assuming that the interaction between the adsorbed molecules can be neglected a self-consistent quantitative analysis of the results can be achieved. Several features of the results, including the magnitudes of the free energies of adsorption suggest that a layer of water approximately one molecule thick was present between the oxide surface and the hydrocarbon medium.
DOI : 10.1007/bf01499908
Anahtar Kelimeler : Mild Steel, Boundary Potential, Metal Specimen, Gold Plate, Zinc Stearate
ISSN: 0303-402X 1435-1536
Sayı: 2
Cilt: 188
Sayfa: 141-147
3
Surface potentials and molecular structure at hydrocarbon/water interfaces
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1962
D. A. Haydon
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Contact (ΔV) potential measurements have been made for the adsorption of dodecyl trimethylammonium bromide and sodium dodecyl sulphate at the n-heptane/ NaCl solution interface. The results are in good agreement with the predictions based on a recently proposed model of ionized films and may be taken as very strong support for this model. The results also show that the nett dipole change occurring normal to the interface on the adsorption of each ion is constant and independent of the surface coverage. Arguments based on the origin of the surface dipole change registered by the surface potential measurements lead to the conclusion that the water molecules at the clean interface must be oriented with their protons towards the hydrocarbon phase. The upper limit to the χ potential across the boundary n-heptane/ 0.1 M NaCl is found to be of the order of −0.9 V.
DOI : 10.1007/bf01542351
Anahtar Kelimeler : Sodium Dodecyl Sulphate, Sodium Dodecyl Sulphate, Surface Active Substance, Glass Sphere, Hydrocarbon Phase
ISSN: 0303-402X 1435-1536
Sayı: 2
Cilt: 185
Sayfa: 148-154
4
Molecular structure at hydrocarbon-water interfaces
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1963
D. A. Haydon
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DOI : 10.1007/bf01621184
Anahtar Kelimeler : Inorganic Salt, Sign Convention, Molar Heat Capacity, Alkyl Sulphate, Free School
ISSN: 0303-402X 1435-1536
Sayı: 2
Cilt: 187
Sayfa: 146-146
5
FUNCTIONS OF THE LIPID IN BILAYER ION PERMEABILITY
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Annals of the New York Academy of Sciences
Yazar(lar) :
D. A. Haydon
Konu :
General Biochemistry, Genetics and Molecular Biology, History and Philosophy of Science
Yıl :
1975
D. A. Haydon
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DOI : 10.1111/j.1749-6632.1975.tb31472.x
ISSN: 0077-8923
Sayı: 1
Cilt: 264
Sayfa: 2-16
6
Properties of lipid bilayers at a water-water interface
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of the American Oil Chemists' Society
Yazar(lar) :
D. A. Haydon
Konu :
Organic Chemistry, General Chemical Engineering
Yıl :
1968
D. A. Haydon
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DOI : 10.1007/bf02652418
ISSN: 0003-021X
Sayı: 4
Cilt: 45
Sayfa: 230-240
Sınıflandırma :
7
The coalescence of droplets stabilised by Viscoelastic Adsorbed Films
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
Byomkesh Biswas , D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1962
D. A. Haydon
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The adsorption of many types of macromolecule at liquid/liquid interfaces very often greatly increases the resistance to coalescence of oil droplets in water and vice verca. A quantitative study has been attempted of the coalescence times for liquid droplets resting under plane liquid/liquid interfaces. These results have been interpreted in the light of the rheology (investigated elsewhere), solubility and structure of the adsorbed films. A general equation has been derived relating the time for coalescence to the viscoelasticity and thickness of the adsorbed film and the critical distortion of the plane interface under the weight of the drop.
DOI : 10.1007/bf01882345
Anahtar Kelimeler : Pectin, Aliphatic Alcohol, Adsorbed Film, Coalescence Time, Hydroxy Ethyl Cellulose
ISSN: 0303-402X 1435-1536
Sayı: 1
Cilt: 185
Sayfa: 31-38
8
The effect of certain small molecules on the elasticity of adsorbed serum albumin films
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
Byomkesh Biswas , D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1962
D. A. Haydon
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The very high interfacial visco-elasticity exhibited by adsorbed albumin films at the petroleum ether/water interface is destroyed by small concentrations of both ionized and unionized surface active substances. The displacement of the albumin from the interface is certainly brought about by high concentrations of the ionic surfactants and it is shown that this is the most likely mechanism of action for these molecules. For the unionized aliphatic alcohol the albumin is not completely displaced from the interface and the elasticity and surface pressure measurements could be explained either by partial displacement or by the assumption that the adsorbed protein is only partly surface denatured.
DOI : 10.1007/bf01797954
Anahtar Kelimeler : Bovine Serum Albumin, Decanol, Bovine Serum Albumin Concentration, Tetradecyl Trimethylammonium, Partial Displacement
ISSN: 0303-402X 1435-1536
Sayı: 1
Cilt: 186
Sayfa: 57-61
9
Fluorescence spectroscopy of planar black lipid membranes
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Die Naturwissenschaften
Yazar(lar) :
H. P. Zingsheim , D. A. Haydon
Konu :
General Medicine, Ecology, Evolution, Behavior and Systematics
Yıl :
1972
D. A. Haydon
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DOI : 10.1007/bf00623134
Anahtar Kelimeler : Lipid, Spectroscopy, Lipid Membrane, Fluorescence Spectroscopy, Black Lipid Membrane
ISSN: 0028-1042 1432-1904
Sayı: 9
Cilt: 59
Sayfa: 419-420
10
The stabilization of titanium dioxide in dry benzene by n-aliphatic carboxylic acids
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
P. T. Dawson , D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1965
D. A. Haydon
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The colloidal stability of rutile, of primary particle radius 25 å, in solutions ofn-aliphatic carboxylic acids in benzene has been examined under rigorously dry conditions. Very stable suspensions were obtained for acid chain lengths of 12 to 18 carbons and surface fractional coverages of 0.4. A rather less stable suspension was given by acetic acid. The C4, 6, 8, and 10 acids gave poor stability. The suspensions generally, and that for lauric acid in particular, appeared to consist mainly of particles whose radius was of the order of 0.08Μ. It has been argued that these particles were probably loosely packed aggregates of primary particles and that their stability was conferred by the C12–18 molecules by an “entropic” repulsion produced when the hydrocarbon chains on opposing particle surfaces tended to interpenetrate. The stability in the acetic, and to a lesser extent, butyric acid systems has been attributed tentatively to the existence of some electrostatic repulsion.
DOI : 10.1007/bf01507759
Anahtar Kelimeler : Rutile, Primary Particle, Octanoic Acid, Fractional Coverage, Ammonium Chloride Solution
ISSN: 0303-402X 1435-1536
Sayı: 2
Cilt: 203
Sayfa: 133-138
11
The effects of short-chain phospholipids on the acetylcholine-activated ion channel
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Pfl�gers Archiv European Journal of Physiology
Yazar(lar) :
M. S. Braun , D. A. Haydon
Konu :
Physiology (medical), Clinical Biochemistry, Physiology
Yıl :
1991
D. A. Haydon
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The effects of a homologous series of shortchain phospholipids, the phosphatidylcholines from dihexanoylglycerophosphocholine (Hxo2GroPCho) to didecanoylglycerophosphocholine, on the nicotinic acetylcholine-activated ion channel in cultured rat muscle cells were investigated. Standard patch-clamp techniques were used to measure single-channel currents in excised patches. All phospholipids investigated markedly reduced the frequency of channel opening in a concentration-dependent manner. Other parameters, such as the mean open time, the duration and frequency of brief closures within an opening, and channel amplitude, were not significantly affected. This effect was independent of the side of the membrane to which the phospholipid was added. Dose/response curves were obtained for Hxo2-, diheptanoyl(Hpo2)- and dinonanoyl(Nno2)GroPCho. The concentration leading to 50% reduction in channel activity decreased upon ascending the homologous series from 16.69 μM Hxo2GroPCho to 4.52 μM and 0.043 μM for Hpo2- and Nno2GroPCho, respectively. The more hydrophobic the molecule the more effective it was, and hence the higher its affinity to the binding site. Calculation of the standard free-energy change of adsorption into the site led to a value of -3.1 kJ/mol, which indicates a very hydrophobic binding site. In conclusion, the phospholipids interact in a non-specific way with the lipid membrane thereby disturbing proper channel function.
DOI : 10.1007/bf00370452
Anahtar Kelimeler : Acetylcholine receptor channel, Patch clamp, Phospholipid
ISSN: 0031-6768 1432-2013
Sayı: 1-2
Cilt: 418
Sayfa: 62-67
12
A Study of the Relation Between Electrokinetic Potential and Surface Charge Density
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Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences
Yayıncı:
The Royal Society
Yazar(lar) :
D. A. Haydon
Konu :
Science and Mathematics, General Science, Mathematics
Yıl :
1960
D. A. Haydon
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Kaydet Alıntıla
The problem of relating electrophoretic mobilities to surface charge densities of particles in suspension has been investigated mainly experimentally. The subject has been approached by comparing the surface potentials at an oil/water interface calculated for adsorbed films of ionic surface active agents, with the zeta potentials of oil droplets in similar surface-active agent solutions. When the bulk viscosity and dielectric constant were used in calculating the zeta potentials, the surface and zeta potentials converged towards low surface charge densities. At higher charge densities the zeta potentials fell well below the surface potentials. The reasons for this discrepancy have been investigated. Misapplication of the Gibbs equation, surface hydrolysis of adsorbed ions, specific interaction of adsorbed ions with counter-ions, surface conductivity, internal circulation in the liquid droplets and double-layer dielectric constants and viscosities were considered. By elimination it has been concluded that only enhanced values of the η/D ratio in the electrical double layer can account for the experimental observations. Independent evidence for this phenomenon has been briefly examined. The circumstances under which a reliable value of surface charge may be determined from electrophoretic measurements have been discussed.
Cilt: 258
Sayı: 1294
Sayfa: pp. 319-328
Yayın Tarihi: 1960-10-25
ISSN: 0080-4630
13
Surface Behaviour of Bacterium coli. II. The Interaction with Phenol
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Dergi Makalesi
Kaynak 1:
JSTOR
Dergi:
Proceedings of the Royal Society of London. Series B, Biological Sciences
Yayıncı:
The Royal Society
Yazar(lar) :
D. A. Haydon
Konu :
Biological Sciences, Science and Mathematics, General Science
Yıl :
1956
D. A. Haydon
Kaydet Alıntıla
It has been found that, when suspended in phenol, the zeta potentials of Bacterium coli decrease with time. Inorganic ions had a retarding effect, particularly higher valent cations. The concentration of phenol required to sterilize a culture in 20 min was markedly increased by the presence of electrolytes, and again the higher valent cations were more efficient. Further investigation, and reference to figures 3 and 4 of part I of this paper (Davies, Haydon & Rideal 1956), showed there to be a general relationship between the sterilization concentration of phenol and the initial zeta potentials of the cells. Examination of these phenomena suggests that death and lysis of the cells are, in phenol, closely related, but there is nothing to indicate which is cause and which is effect. The conclusions do, however, provide support for the suggestions of Hotchkiss (1946) and Gale & Taylor (1947) that death of the organism in phenol is due to a lytic process.
Cilt: 145
Sayı: 920
Sayfa: pp. 383-391
Yayın Tarihi: 1956-07-24
ISSN: 0080-4649
14
An Investigation of Droplet Oscillation during Mass Transfer. I. The Conditions Necessary, and the Source of the Energy for the Oscillations
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Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences
Yayıncı:
The Royal Society
Yazar(lar) :
D. A. Haydon
Konu :
Science and Mathematics, General Science, Mathematics
Yıl :
1958
D. A. Haydon
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Kaydet Alıntıla
The violent and erratic motion often exhibited by pendent drops during diffusion of a solute across their interfaces has been investigated qualitatively and quantitatively. The qualitative tests indicate that a local lowering of interfacial tension by the solute is a necessary condition for this phenomenon. A mechanism is proposed to account for transient non-uniformity of interfacial tension during diffusion. It is based on two assumptions regarding the course of the diffusion in the region of the interface and the existence of convection currents or similar disturbances in the liquids. The change in energy producing one series of oscillations of a drop is estimated with a view to comparison with the energy dissipated, as determined in part II.
Cilt: 243
Sayı: 1235
Sayfa: pp. 483-491
Yayın Tarihi: 1958-02-11
ISSN: 0080-4630
15
Cationic dye adsorption in sugar cane juice
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Dergi Makalesi
Kaynak 1:
Wiley Online Library
Dergi:
Journal of Applied Chemistry
Yazar(lar) :
M. C. Bennett , D. A. Haydon
Yıl :
2007
D. A. Haydon
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Kaydet Alıntıla
DOI : 10.1002/jctb.5010090905
ISSN: 0021-8871
Sayı: 9
Cilt: 9
Sayfa: 482-486
16
The thickness and electrical properties of black hydrocarbon films in aqueous solutions
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Kolloid-Zeitschrift & Zeitschrift für Polymere
Yazar(lar) :
T. Hanai , D. A. Haydon , Janet Taylor
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1964
D. A. Haydon
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DOI : 10.1007/bf01500884
Anahtar Kelimeler : Free School, Surface Areae, Free Energy Gradient, Polymer Single Crystal, Density Gradient Column
ISSN: 0303-402X 1435-1536
Sayı: 1
Cilt: 195
Sayfa: 41-42
17
Actions of n-Alcohols on Nicotinic Acetylcholine Receptor Ion Channels in Cultured Rat Muscle Cells
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Annals of the New York Academy of Sciences
Yazar(lar) :
RUTH D. MURRELL , D. A. HAYDON
Konu :
General Biochemistry, Genetics and Molecular Biology, History and Philosophy of Science
Yıl :
1991
D. A. HAYDON
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DOI : 10.1111/j.1749-6632.1991.tb33864.x
ISSN: 0077-8923
Sayı: 1 Molecular and
Cilt: 625
Sayfa: 365-373
18
The thickness, composition and structure of some lipid bilayers and natural membranes
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
The Journal of Membrane Biology
Yazar(lar) :
R. Fettiplace , D. M. Andrews , D. A. Haydon
Konu :
Cell Biology, Physiology, Biophysics
Yıl :
1971
D. A. Haydon
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It has been shown that the capacitance, thickness and composition of black lipid films may depend strongly on the hydrocarbon solvent used in their formation. By the use of n-hexadecane, films have been formed which contain effectively no solvent and which are comparable to the leaflets of the mesomorphic phase of the pure lipid. These films have capacitances of ca. 0.6 μF/cm2 and hydrocarbon thicknesses of ca. 31 Å. Thinner black films of higher capacitances are also described. The capacitances of biological membranes are, in contrast, nearer to 1 μF/cm2, and it is suggested that the hydrocarbon region in these membranes may often be thinner than in the lipid leaflets. This suggestion is consistent with some X-ray and lipid composition data. It is pointed out that if the membranes contain abnormally thin lipid leaflets, the area per polar head group of the phospholipid must be increased, and that hydrocarbon is thereby exposed to the aqueous phases. Non-polar protein residues could then interact with these hydrocarbon areas, thus tending to stabilize the expanded leaflet.
DOI : 10.1007/bf01870555
Anahtar Kelimeler : Lipid, Hydrocarbon, Lipid Bilayer, Head Group, Composition Data
ISSN: 0022-2631 1432-1424
Sayı: 3
Cilt: 5
Sayfa: 277-296
19
van' der Waals-Kräfte in Öl-Wasser-Systemen
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Colloid and Polymer Science
Yazar(lar) :
J. Requena , D. E. Brooks , D. A. Haydon
Konu :
Materials Chemistry, Colloid and Surface Chemistry, Polymers and Plastics, Physical and Theoretical Chemistry
Yıl :
1979
D. A. Haydon
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DOI : 10.1007/bf01521607
ISSN: 0303-402X 1435-1536
Sayı: 4
Cilt: 257
Sayfa: 447-447
20
Monolayers at Liquid Interfaces
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Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
D. A. HAYDON , M. J. JAYCOCKD. A. HAYDON , M. J. JAYCOCK
Yıl :
1966
D. A. HAYDON
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DOI : 10.1038/209565a0
ISSN: 0028-0836
Sayı: 5023
Cilt: 209
Sayfa: 565-566
21
Mechanisms of Adsorption from Solution
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Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
D. A. HAYDON , R. H. OTTEWILLD. A. HAYDON , R. H. OTTEWILL
Yıl :
1963
D. A. HAYDON
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Kaydet Alıntıla
DOI : 10.1038/2001157a0
ISSN: 0028-0836
Sayı: 4912
Cilt: 200
Sayfa: 1157-1158
22
Local anaesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Pflügers Archiv - European Journal of Physiology
Yazar(lar) :
J. R. Elliott , D. A. Haydon , B. M. Hendry
Konu :
Physiology (medical), Clinical Biochemistry, Physiology
Yıl :
1987
D. A. Haydon
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(1). The effects of benzene and several of its derivatives on sodium currents in the voltage-clamped squid giant axon have been studied. Substances tested were benzene, aniline, benzyl alcohol, propiophenone, 4-aminopropiophenone, methyl benzoate, ethyl benzoate, and 4-amino ethyl benzoate (benzocaine). (2.) All substances tested reduced the sodium current in both intact axons and axons internally perfused with CsF. (3.) There were four major actions of benzene on the sodium current: (a) an increase in the resting level of inactivation, (b) an increase in the depolarization required to produce tha maximum current, (c) a decrease in the maximum sodium conductance, and (d) an increase in the rate of inactivation. (4.) 4-amino ethyl benzoate (benzocaine) had actions on the sodium current which were very similar to those of benzene with the exception that the rate of inactivation was scarcely affected and, at comparable shifts, the slope of the steady state inactivation curve was slightly smaller. (5.) The results obtained with the substances structurally intermediate between benzene and 4-amino ethyl benzoate allow some conclusions to be drawn as to the role of each functional group.
DOI : 10.1007/bf00584658
Anahtar Kelimeler : Giant axon, Local anaesthesia, Sodium current, Benzocaine
ISSN: 0031-6768 1432-2013
Sayı: 6
Cilt: 409
Sayfa: 589-595
23
Discreteness of Conductance Change in Bimolecular Lipid Membranes in the Presence of Certain Antibiotics
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Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
S. B. HLADKY , D. A. HAYDONS. B. HLADKY , D. A. HAYDON
Yıl :
1970
D. A. HAYDON
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Kaydet Alıntıla
DOI : 10.1038/225451a0
ISSN: 0028-0836
Sayı: 5231
Cilt: 225
Sayfa: 451-453
24
Electrical Double Layer in Surface and Colloid Chemistry
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
D. A. HAYDON , R. H. OTTEWILLD. A. HAYDON , R. H. OTTEWILL
Yıl :
1965
D. A. HAYDON
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Kaydet Alıntıla
DOI : 10.1038/205348a0
ISSN: 0028-0836
Sayı: 4969
Cilt: 205
Sayfa: 348-349
25
Mapping of general anaesthetic target sites
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Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
J. R. ELLILOTT , D. A. HAYDONJ. R. ELLILOTT , D. A. HAYDON
Yıl :
1986
D. A. HAYDON
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Kaydet Alıntıla
DOI : 10.1038/319077a0
ISSN: 0028-0836
Sayı: 6048
Cilt: 319
Sayfa: 77-78
26
Local anesthetic action of carboxylic esters: Evidence for the significance of molecular volume and for the number of sites involved
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
The Journal of Membrane Biology
Yazar(lar) :
J. R. Elliott , R. D. Murrell , D. A. Haydon
Konu :
Cell Biology, Physiology, Biophysics
Yıl :
1987
D. A. Haydon
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Kaydet Alıntıla
The effects of the homologous series of carboxylic esters, methyl propionate to methyl decanoate, on the steadystate inactivation of the sodium current in squid axons have been studied. The esters moved the relationship between the inactivation parameter,h ∞, and the membrane potential in the hyperpolarizing direction, thus reducing the number of sodium channels available at the resting potential. The concentration dependence of the shift at the mid-point of the curve ofh ∞ against potential has been measured for all esters except decanoate, which was almost inactive. Two aspects of these concentration dependences suggest that molecular volume is an important determinant of the effectiveness of each ester. Firstly, there is a sharp decline in activity above methyl hexanoate. This cut-off in activity resembles that for hydrocarbons where it has been suggested [e.g., Haydon, D.A., Urban, B.W. 1983)J. Physiol. (London) 341:411–427] to a result from a decrease in uptake with increasing molecular volume. (Further data for the hydrocarbonsn-butane ton-heptane are reported here.) Secondly, the smallest compounds, methyl propionate and methyl butyrate, are less effective than would be predicted if equal membrane concentrations of each ester produced the same shift. The aqueous concentration dependences for these esters indicate that below methyl hexanoate, as the series is descended, progressively higher membrane concentrations are required to produce a given shift. This would be expected if the volume of ester in the membrane, rather than the number of molecules, is important. Differences between the effects of the ester series on steady-state inactivation and on the reduction of the peak sodium current suggest that, in the unclamped squid axon, excitability is influenced by at least two distinct mechanisms in which at least two sites of action are involved.
DOI : 10.1007/bf01869159
Anahtar Kelimeler : anesthetic mechanisms, local anesthesia, peripheral nerve, sodium current, inactivation, anesthetic esters
ISSN: 0022-2631 1432-1424
Sayı: 2
Cilt: 95
Sayfa: 143-149
27
Fusion of photoreceptor membrane vesicles
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Dergi Makalesi
Kaynak :
Springer Link
Dergi:
The Journal of Membrane Biology
Yazar(lar) :
W. T. Mason , S. B. Hladky , D. A. Haydon
Konu :
Cell Biology, Physiology, Biophysics
Yıl :
1979
D. A. Haydon
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Kaydet Alıntıla
Then-alkyl bromides with 6 to 10 carbons induce formation of vesicles of 5 to 100 μm diameter from the small vesicles (0.1 μm average diameter) produced by disruption of the discs from frog rod photoreceptors. Then-alkanes,n-alkyl iodides andn-alkyl chlorides are relatively ineffective. The formation of large vesicles is independent of calcium concentration and is distinguished from fusion processes previously reported by the large number of vesicles involved. The results reported here together with others suggest the occurrence of multiple fusion (and/or rupture-resealing) events between vesicles, induced by then-alkyl bromides.
DOI : 10.1007/bf01961379
Anahtar Kelimeler : Calcium, Chloride, Bromide, Iodide, Human Physiology
ISSN: 0022-2631 1432-1424
Sayı: 2
Cilt: 46
Sayfa: 171-181
28
Contact Angles for Thin Lipid Films and the Determination of London-van der Waals Forces
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Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
D. A. HAYDON , J. L. TAYLORD. A. HAYDON , J. L. TAYLOR
Yıl :
1968
D. A. HAYDON
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Kaydet Alıntıla
DOI : 10.1038/217739a0
ISSN: 0028-0836
Sayı: 5130
Cilt: 217
Sayfa: 739-740

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