Piri Keşif Aracı

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Increasing insecticide resistance of mosquitoes represents a public health threat, and underlying mechanisms are poorly understood. Here, Ingham et al. identify putative insecticide resistance genes in Anopheles gambiae populations across Africa and develop a web-based application that maps their expression.

Kaynak 1:

https://doi.org/10.1038/s41467-018-07615-x arayıcılığı görüntüle.
Kaynak 2:

https://www.nature.com/articles/s41467-018-07615-x arayıcılığı görüntüle.

DOI : 10.1038/s41467-018-07615-x

ISSN: 2041-1723
Cilt: 9
Sayı: 1
Sayfa: 1 - 11

Sınıflandırma :

Biyotıp %100

Tropik ilaç %100

2

Insect glutathione transferases and insecticide resistance

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

A. A. Enayati , H. Ranson , J. Hemingway

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2005

H. Ranson

Özet Ek Bilgiler

Kaydet

Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in aerobic organisms. They play a central role in the detoxification of both endogenous and xenobiotic compounds and are also involved in intracellular transport, biosynthesis of hormones and protection against oxidative stress. Interest in insect GSTs has primarily focused on their role in insecticide resistance. GSTs can metabolize insecticides by facilitating their reductive dehydrochlorination or by conjugation reactions with reduced glutathione, to produce water‐soluble metabolites that are more readily excreted. In addition, they contribute to the removal of toxic oxygen free radical species produced through the action of pesticides. Annotation of the Anopheles gambiae and Drosophila melanogaster genomes has revealed the full extent of this enzyme family in insects. This mini review describes the insect GST enzyme family, focusing specifically on their role in conferring insecticide resistance.

DOI : 10.1111/j.1365-2583.2004.00529.x

ISSN: 0962-1075
Sayı: 1
Cilt: 14
Sayfa: 3-8

3

Characterizing the effects of valuation methodology in function-based benefits transfer

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Ecological Economics

Yayıncı:

Elsevier

Yazar(lar) :

Robert J. Johnston , Elena Y. Besedin , Matthew H. Ranson

Yıl :

2006

Matthew H. Ranson

Özet Ek Bilgiler

Kaydet

Meta-analyses have demonstrated that willingness to pay (WTP) estimates vary systematically according to methodological factors. The benefits transfer literature provides little guidance with regard to the treatment of such effects. Transfers are typically conducted by ignoring such effects, using ad hoc adjustments, or otherwise suppressing information regarding the sensitivity of WTP to methodological attributes. This paper illustrates a means to characterize methodological effects within benefits transfer, based on an application of the common bootstrap. Drawing from meta-analysis, the approach characterizes the sampling distribution of WTP with respect to patterns of methodological variation present in underlying studies. Results provide a means to characterize the extent of variation associated with predefined groups of methodological attributes, providing transparent information on the sensitivity of WTP not typically available in benefits transfer.

DOI : 10.1016/j.ecolecon.2006.03.020

Anahtar Kelimeler : Benefits transfer, Meta-analysis, Willingness to pay, Bootstrap, Water quality, Methodology

ISSN: 0921-8009
Sayı: 2
Cilt: 60
Sayfa: 407-419

Sınıflandırma :

Matematik %35

Çevre Biliminde Matematiksel Uygulamalar %81

4

Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

C. Strode , K. Steen , F. Ortelli , H. Ranson

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2006

H. Ranson

Özet Ek Bilgiler

Kaydet

The diverse habitats and diets encountered during the life cycle of an Anopheles mosquito have necessitated the development of extensive families of detoxification enzymes. Expansion of the three detoxification enzyme families (cytochrome P450s, carboxylesterases and glutathione transfereases), has occurred in mosquitoes compared with Drosophila, however, very little is known regarding the developmental expression of theses genes. Using a custom made microarray we determined the expression profile of the detoxification genes in adults, larvae and pupae of the malaria vector A. gambiae. The expression of approximately one quarter of these genes was developmentally regulated. The expression profile of each of these genes and the information this data provides on putative functions of the mosquito detoxification enzymes is discussed.

DOI : 10.1111/j.1365-2583.2006.00667.x

ISSN: 0962-1075
Sayı: 4
Cilt: 15
Sayfa: 523-530

5

Reminiscences of the Civil War by a Confederate Staff Officer: (First Paper)

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

The Sewanee Review

Yayıncı:

Johns Hopkins University Press

Yazar(lar) :

A. R. H. Ranson

Konu :

Humanities, Language & Literature

Yıl :

1913

H. Ranson

Özet Ek Bilgiler

Kaydet

REMINISCENCES OF THE CIVIL WAR BY A CONFEDERATE STAFF OFFICER* (FIRST PAPER) Plantation Life in Virginia Before the War Everybody knows that Harper's Ferry was the scene of the John Brown raid in October, 1859, but there are things concerning the raid and Harper's Ferry and its surroundings which are not known to everybody. In Harper's Ferry there was an armory and arsenal belong ing to the government. At the time of the raid large quantities of arms, 100,000 stand of rifles, had been made there and were stored in the arsenal for use when needed. The town was situated at the northeastern end of the great Valley of Virginia, at the junction of the Potomac and Shenandoah rivers. It is supposed that this valley was, in the early days of the world, a great lake 120 miles long and fourteen to twenty miles wide, and that the pressure of waters had broken through the moun tain barriers at Harper's Ferry, draining the lake, and leaving a fertile valley, washed on the south side by the Shenandoah river and on the northeast by the Potomac. Whether or not the theory of the lake be true, certainly an alluvial deposit made the valley celebrated for its fertility, yielding to the farmer a rich return for his labor, and sustaining a large population, prosper ous, comfortable, and happy. At Shepherdstown, twelve miles above Harper's Ferry, on the Potomac, the first boat was propelled by steam ; in 1786 Rum sey, the inventor, launched his boat on the waters of the Poto mac and attained a speed of four or five miles an hour against the current. Rumsey lived alone in a log cabin on the banks of the river, was silent and meditative, and was generally thought by his neighbors to be wrong in his head. There was a path known as * Copyright, 1913, by the author. This is the first of a series of articles by the same author which will run through several numbers of the Review.?Editor.

Cilt: 21
Sayı: 4
Sayfa: pp. 428-447
Yayın Tarihi: 1913-10-01
ISSN: 0037-3052

6

Reminiscences of the Civil War by a Confederate Staff Officer: (Second Paper)

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

The Sewanee Review

Yayıncı:

Johns Hopkins University Press

Yazar(lar) :

A. R. H. Ranson

Konu :

Humanities, Language & Literature

Yıl :

1914

H. Ranson

Özet Ek Bilgiler

Kaydet

THE SEWANEE REVIEW Vol. XXII] JANUARY, 1914 [No. 1 REMINISCENCES OF THE CIVIL WAR BY A CONFEDERATE STAFF OFFICER* (SECOND PAPER) The Beginning of the Conflict On the 19th of April, 1861, I was living in Baltimore where, having removed from Jefferson County, Virginia, about one year before, I was in business as partner in the firm of-. I had abandoned my native state on account of the very un settled condition of the county, brought about by the Brown Raid and subsequent events, Jefferson County having been the scene of the Raid and of a military occupation and excitement unknown in our country since the War of 1812. There was a feeling, too, that the beginning of the end of slavery had come, and that its demise would be attended with a convulsion in which we on the border were not sufficiently interested to in volve ourselves. About two o'clock on the morning of the 19th, I left my office on Spear's Wharf and went to the Bank of Baltimore, corner of Baltimore and Saint Paul Streets. After finishing my business at the bank, I was asked by a friend to walk with him to Camden Station to see what was going on, as there were rumors that trouble would come of the passage of troops (called for by Lincoln from the Northern states) through Baltimore. * Copyright, 1914, by the author. This is the second of a series of articles by the same author which will run throughout the year.?Editor.

Cilt: 22
Sayı: 1
Sayfa: pp. 1-23
Yayın Tarihi: 1914-01-01
ISSN: 0037-3052

7

Mutated sodium channel genes and elevated monooxygenases are found in pyrethroid resistant populations of Sri Lankan malaria vectors

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Pesticide Biochemistry and Physiology

Yayıncı:

Elsevier

Yazar(lar) :

S.H.P.P. Karunaratne , N.J. Hawkes , M.D.B. Perera , H. Ranson , J. Hemingway

Yıl :

2007

H. Ranson

Özet Ek Bilgiler

Kaydet

The present status of pyrethroid resistance in vectors of malaria; Anopheles culicifacies and Anopheles subpictus, was tested in two malarious Districts, Anuradhapura and Trincomalee, of Sri Lanka. Both species were resistant to permethrin and susceptible to cypermethrin and cyfluthrin. An. subpictus were resistant to deltamethrin. λ-Cyhalothrin and etofenprox resistance was shown only by Anuradhapura An. subpictus. Although there were no differences among the populations for esterase and glutathione S-transferase activities, increased monooxygenase levels were found among Trincomalee populations. The voltage-gated sodium channel gene, the target site gene of pyrethroids, was partially sequenced to screen for mutations previously associated with insecticide resistance. The classic leucine to phenylalanine substitution, TTA to TTT, was detected in An. subpictus. It appears that both kdr type and monooxygenase resistance underlie pyrethroid resistance in these two malaria vectors of Sri Lanka.

DOI : 10.1016/j.pestbp.2006.10.001

Anahtar Kelimeler : Pyrethroid resistance, Malaria vectors, Anopheles culicifacies, Anopheles subpictus, kdr, Monooxygenases

ISSN: 0048-3575
Sayı: 1
Cilt: 88
Sayfa: 108-113

Sınıflandırma :

Biyotıp %51

Tropik ilaç %100

Yaşam Bilimleri %49

Tıbbi Mikrobiyoloji %89

8

Reminiscences of the Civil War by a Confederate Staff Officer: (Third Paper)

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

The Sewanee Review

Yayıncı:

Johns Hopkins University Press

Yazar(lar) :

A. R. H. Ranson

Konu :

Humanities, Language & Literature

Yıl :

1914

H. Ranson

Özet Ek Bilgiler

Kaydet

THE sewanee review Vol. XXII] APRIL, 1914 [No. 2 REMINISCENCES OF THE CIVIL WAR BY A CONFEDERATE STAFF OFFICER* (THIRD PAPER) The Return South I arrived in Baltimore at night and went directly to the house of a friend. His consternation on seeing me was evident at once. Baltimore was under a reign of terror. Everybody was watched and arrests and incarcerations were matters of every day occurrence. The disaster at Bull Run had intensified feeling and sharpened political animosities. I was told that General Banks would not respect my parole and would put me in prison if I presented McClellan's letter, and that my presence on the streets would lead to my immediate arrest by the civil authorities. I was also placing my host in danger for harboring a Rebel soldier. In a hurried consultation with a few friends, it was decided to send me to the country that night, where I should be safe from observation. Here I remained several days, known as Mr. Davis from England, and spending the time in trying to arrange, with the aid of my friends, a plan for my return to Virginia, but I finally decided to abandon all offers of aid and act for myself. I was on parole and was strictly observing its requirements. Any attempt to pass the line by any of the usual secret methods * Copyright, 1914, by the author. This is the third of a series of articles by the same author which will run throughout the year.?Editor. 9

Cilt: 22
Sayı: 2
Sayfa: pp. 129-150
Yayın Tarihi: 1914-04-01
ISSN: 0037-3052

9

Reminiscences of the Civil War by a Confederate Staff Officer: (Sixth Paper)

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

The Sewanee Review

Yayıncı:

Johns Hopkins University Press

Yazar(lar) :

A. R. H. Ranson

Konu :

Humanities, Language & Literature

Yıl :

1915

H. Ranson

Özet Ek Bilgiler

Kaydet

REMINISCENCES OF THE CIVIL WAR BY A CONFEDERATE STAFF OFFICER* (SIXTH PAPER) Reconstruction Days in the South One evening in February of the late winter of 1864, on return ing to camp near Petersburg after a hard day's work, I found my tent occupied by a man who had taken possession of my bed and was covered up in my blankets. I asked the servants the meaning of it, and they said he merely asked for Major Ranson's tent and forthwith took possession. On examination I found that he was a youth about sixteen years old, very red in the face, and in a stupor. I thought he must have been drinking, but there was no smell of liquor about him. Failing to arouse him I sent for Dr. Gild, medical director, who after examination pro nounced him sober but in typhoid fever. Here was a predica ment; but Dr. Gild aroused him enough to learn that he was my nephew, John Washington, whom I had not seen since he was four years old, and that he had run away from his home in Cali fornia to join the Southern Army, crossing the plains mainly on foot and taking six months in the journey. Then he lapsed into unconsciousness. In this dilemma I went to General Lee for advice. He said promptly, "Enlist him in some battery, and then Dr. Gild can send him to the hospital in Petersburg." Six weeks after that John appeared again at my camp. He went to the hospital a chubby boy, but was now a tall, gaunt man, as weak as a child and as hungry as a hawk. As my ration was hardly sufficient for me, I could not feed him, and in my second dilemma I went again to General Lee. He said as promptly as before, "Leave his name and company with me and I will order him to report to you for duty as courier." So as John had no horse he be came my courier on foot, the only one of the kind I have ever * Copyright, 1915, by the author. The first of this series of articles by Major Ranson was published in the October, 1913, issue of the Review. This is the concluding paper.?Editor.

Cilt: 23
Sayı: 1
Sayfa: pp. 75-83
Yayın Tarihi: 1915-01-01
ISSN: 0037-3052

10

Reminiscences of the Civil War by a Confederate Staff Officer

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

The Sewanee Review

Yayıncı:

Johns Hopkins University Press

Yazar(lar) :

A. R. H. Ranson

Konu :

Humanities, Language & Literature

Yıl :

1914

H. Ranson

Özet Ek Bilgiler

Kaydet

REMINISCENCES OF THE CIVIL WAR BY A CONFEDERATE STAFF OFFICER* (FOURTH PAPER) The Army of Tennessee Some days were necessary for the preparations for my journey to Tennessee. Besides my own affairs, selling my horses and buying my outfit, I had commissions from all the members of the staff for all manner of things, and shopping was tedious and laborious. I finally started, overburdened with a mass of luggage, packages of boots, saddles, bridles, and clothing, and reached Murfreesboro the latter part of December, 1862. Our brigade of cavalry was on the right flank of General Bragg's army, doing picket duty. We had no tents and usually slept in the open, though the weather was cold and rainy. As I had not been on field duty now for a year, sleeping on the damp ground brought on an attack of rheumatic fever, and I was sent to the rear by the surgeon the night before the battle of Murfreesboro. My servant Dick got an old tent, and in this I lay down that night, burning with fever and aching all over. In the morning the battle began, and ill as I was, I could not lie still. So I ordered my horse and rode to the front I was in the worst place in the world, in the rear of a line of infantry, under a heavy fire from the enemy's batteries. The infantry was under the shelter of the rising ground, I was in the open behind them, and the shells were skipping gaily over the ground and bursting uncomfortably near. I spent the day roaming about in search of my command, but it had moved during the night, and no one could give me any information concerning its whereabouts. When night came on, I went back to my old tent and lay down, sick and wretched. During the night the General and staff came into camp, and then I learned that a retreat had been ordered. It seemed to * Copyright, 1914, by the author. This is the fourth of a series of articles by the same author which will run throughout the year.?Editor.

Kaynak 1:

http://www.jstor.org/stable/27532737 arayıcılığı görüntüle.
Kaynak 2:

http://www.jstor.org/stable/27532756 arayıcılığı görüntüle.

Cilt: 22
Sayı: 3
Sayfa: pp. 298-318
Yayın Tarihi: 1914-07-01
ISSN: 0037-3052

11

Do bednets including piperonyl butoxide offer additional protection against populations of Anopheles gambiae s.l. that are highly resistant to pyrethroids? An experimental hut evaluation in Burkina Fasov.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Med. Vet. Entomol.

Yazar(lar) :

K H Toe , P Müller , A Badolo , A Traore , N Sagnon , R K Dabiré , H Ranson

Yıl :

2018

H Ranson

Piri Tam Metin Bulucu Özet

Kaydet

Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance are very high. This study was conducted in two settings in southwest Burkina Faso, Vallée du Kou 5 and Tengrela, where Anopheles gambiae s.l. (Diptera: Culicidae) mortality rates in World Health Organization (WHO) discriminating dose assays were < 14% for permethrin and < 33% for deltamethrin. When mosquitoes were pre-exposed to PBO in WHO tube assays, mortality rates increased substantially but full susceptibility was not restored. Molecular characterization revealed high levels of kdr alleles and elevated levels of P450s previously implicated in pyrethroid resistance. In cone bioassays and experimental huts, PBO LLINs outperformed the pyrethroid-only equivalents from the same manufacturers. Blood feeding rates were 1.6-2.2-fold lower and mortality rates were 1.69-1.78-fold greater in huts with PBO LLINs vs. non-PBO LLINs. This study indicates that PBO LLINs provide greater personal and community-level protection than standard LLINs against highly pyrethroid-resistant mosquito populations.

Kaynak 1:

https://www.ncbi.nlm.nih.gov/pubmed/29998497 arayıcılığı görüntüle.
Kaynak 2:

https://onlinelibrary.wiley.com/doi/10.1111/mve.12316 arayıcılığı görüntüle.

DOI : 10.1111/mve.12316

Anahtar Kelimeler : PBO, insecticide resistance, insecticide resistance management, longlasting insecticidal nets

12

Microarray analysis of a pyrethroid resistant African malaria vector, Anopheles funestus, from southern Africa

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Pesticide Biochemistry and Physiology

Yayıncı:

Elsevier

Yazar(lar) :

R.N. Christian , C. Strode , H. Ranson , N. Coetzer , M. Coetzee , L.L. Koekemoer

Yıl :

2011

H. Ranson

Özet Ek Bilgiler

Kaydet

Anopheles funestus is one of the major malaria vectors in southern Africa and several populations in this region are resistant to pyrethroids. The current study uses a microarray based approach to identify genes up-regulated in the pyrethroid resistant population, FUMOZ, from Mozambique. As the full set of detoxification genes in A. funestus are unknown, this study investigated the utility of the Anopheles gambiae ‘detox chip’ to screen for differentially expressed detoxification genes in A. funestus. Differential expression of detoxification genes in 3 day old adult females and males from the FUMOZ resistant strain and the FANG susceptible strain was identified using the A. gambiae ‘detox chip’. After optimization of the hybridization conditions, over 90% of the probes showed a positive signal. Only three genes were significantly (p < 0.001) differentially expressed in the females, CYP6P9 (5.4-fold), COI (2.7-fold) and CYP6M7 (1.8-fold). The same genes were also significantly differentially expressed in the adult males, CYP6P9 (6.0-fold), COI (2.9-fold) and CYP6M3 (3.6-fold) together with an additional 21 transcripts. Quantitative PCR (qPCR) analysis was conducted to validate the microarray results. This study demonstrated that heterologous hybridization is a helpful tool in identifying detoxification genes differentially expressed in A. funestus strains.

DOI : 10.1016/j.pestbp.2010.11.010

Anahtar Kelimeler : Microarrays, A. funestus, u2018detox chipu2019, Pyrethroid resistance, Cytochrome P450

ISSN: 0048-3575
Sayı: 2
Cilt: 99
Sayfa: 140-147

Sınıflandırma :

Biyotıp %100

Tropik ilaç %100

13

Involvement of cytochrome P450 monooxygenases in the response of mosquito larvae to dietary plant xenobiotics

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Insect Biochemistry and Molecular Biology

Yayıncı:

Elsevier

Yazar(lar) :

J.P. David , S. Boyer , A. Mesneau , A. Ball , H. Ranson , C. Dauphin-Villemant

Yıl :

2006

H. Ranson

Özet Ek Bilgiler

Kaydet

The response of mosquito larvae to plant toxins found in their breeding sites was investigated by using Aedes aegypti larvae and toxic arborescent leaf litter as experimental models. The relation between larval tolerance to toxic leaf litter and cytochrome P450 monooxygenases (P450 s) was examined at the toxicological, biochemical and molecular levels. Larvae pre-exposed to toxic leaf litter show a higher tolerance to those xenobiotics together with a strong increase in P450 activity levels. This enzymatic response is both time- and dose-dependent. The use of degenerate primers from various P450 genes (CYPs) allowed us to isolate 16 new CYP genes belonging to CYP4, CYP6 and CYP9 families. Expression studies revealed a 2.3-fold over-expression of 1 CYP gene (CYP6AL1) after larval pre-exposure to toxic leaf litter, this gene being expressed at a high level in late larval and pupal stages and in fat bodies and midgut. The CYP6AL1 protein has a high level of identity with other insect's CYPs involved in xenobiotic detoxification. The role of CYP genes in tolerance to natural xenobiotics and the importance of such adaptive responses in the capacity of mosquitoes to colonize new habitats and to develop insecticide resistance mechanisms are discussed.

DOI : 10.1016/j.ibmb.2006.02.004

ISSN: 0965-1748
Sayı: 5
Cilt: 36
Sayfa: 410-420

Sınıflandırma :

Yaşam Bilimleri %100

Entomoloji %75

14

Insecticide resistance in the major dengue vectors Aedes albopictus and Aedes aegypti

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Pesticide Biochemistry and Physiology

Yayıncı:

Elsevier

Yazar(lar) :

J. Vontas , E. Kioulos , N. Pavlidi , E. Morou , A. della Torre , H. Ranson

Yıl :

2012

H. Ranson

Özet Ek Bilgiler

Kaydet

Aedes mosquitoes are major vectors of human diseases, such as the dengue fever, chikungunya and yellow fever. Their control largely relies on insecticides applied to mosquito larvae habitats, or indoors against adult mosquitoes. However, insecticide resistance has evolved in many Aedes aegypti mosquito populations worldwide and there is evidence that it has compromised the success of control interventions. The levels of resistance in Aedes albopictus is relatively low at present compared to Ae. aegypti, possibly due to the reduced exposure of this more exophilic species to insecticides, particularly those targeting the adult stage. This paper reviews Ae. albopictus susceptibility/resistance status, as well as reports some new bioassay data from European populations (Greece and Italy). The most recent molecular research into Ae. aegypti insecticide resistance mechanisms is also reviewed, with emphasis on neurotoxic insecticides.

DOI : 10.1016/j.pestbp.2012.05.008

Anahtar Kelimeler : Dengue, Chikungunya, Detoxification, Target site resistance, Larvicide

ISSN: 0048-3575
Sayı: 2
Cilt: 104
Sayfa: 126-131

Sınıflandırma :

Biyotıp %100

Tropik ilaç %54

Parazitoloji ve Enfeksiyon Hastalıkları %46

15

WITH PROFITS WITHOUT MYSTERY with DISCUSSION

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

Transactions of the Faculty of Actuaries

Yayıncı:

Cambridge University Press

Yazar(lar) :

R. H. Ranson , C. P. Headdon

Konu :

Economics, Business & Economics Collection, Finance, Business

Yıl :

1989

H. Ranson

Özet Ek Bilgiler

Kaydet

The paper describes the philosophy of with-profits business which has been developed in the authors' office, as a practical illustration of the running of such business in modern conditions. A description is given of how the philosophy is implemented in the main areas of actuarial management, including valuation methods, bonus distribution, product design and expense control. The discussion is extended to address a number of topics which are the subject of current debate including the financial strength of offices, future bonus prospects and disclosure of expenses.

Cilt: 42
Sayfa: pp. 139-186
Yayın Tarihi: 1989-01-01
ISSN: 0071-3686

16

Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Heredity

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

C Witzig , M Parry , J C Morgan , H Irving , A Steven , N Cuamba , C Kerah-Hinzoumbé , H Ranson , C S WondjiC Witzig , M Parry , J C Morgan , H Irving , A Steven , N Cuamba , C Kerah-Hinzoumbé , H Ranson , C S Wondji

Yıl :

2013

H Ranson H Ranson

Ek Bilgiler

Kaydet

DOI : 10.1038/hdy.2012.112

ISSN: 0018-067X
Sayı: 4
Cilt: 110
Sayfa: 389-397

17

Genetic mapping of two loci affecting DDT resistance in the malaria vector Anopheles gambiae

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

H. Ranson , B. Jensen , X. Wang , L. Prapanthadara , J. Hemingway , F. H. Collins

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2000

H. Ranson

Ek Bilgiler

Kaydet

DOI : 10.1046/j.1365-2583.2000.00214.x

ISSN: 0962-1075
Sayı: 5
Cilt: 9
Sayfa: 499-507

18

WITH PROFITS WITHOUT MYSTERY

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

Journal of the Institute of Actuaries (1886-1994)

Yayıncı:

Cambridge University Press

Yazar(lar) :

R. H. Ranson , C. P. Headdon

Konu :

Economics, Business & Economics Collection, Finance, Business

Yıl :

1989

H. Ranson

Özet Ek Bilgiler

Kaydet

The paper describes the philosophy of with-profits business which has been developed in the authors' office, as a practical illustration of the running of such business in modern conditions. A description is given of how the philosophy is implemented in the main areas of actuarial management, including valuation methods, bonus distribution, product design and expense control. The discussion is extended to address a number of topics which are the subject of current debate including the financial strength of offices, future bonus prospects and disclosure of expenses.

Kaynak 1:

http://www.jstor.org/stable/41140940 arayıcılığı görüntüle.
Kaynak 2:

http://doi.org/10.1017/S0071368600009964 arayıcılığı görüntüle.

Cilt: 116
Sayı: 3
Sayfa: pp. 301-345
Yayın Tarihi: 1989-12-01
ISSN: 0020-2681

19

The Anopheles gambiae ATP-binding cassette transporter family: phylogenetic analysis and tissue localization provide clues on function and role in insecticide resistance

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

P. Pignatelli , V. A. Ingham , V. Balabanidou , J. Vontas , G. Lycett , H. Ranson

Yıl :

2017

H. Ranson

Özet Ek Bilgiler

Kaydet

The role of ATP‐binding cassette (ABC) transporters in conferring insecticide resistance has received much attention recently. Here we identify ABC transporters differentially expressed in insecticide‐resistant populations of the malaria vector, Anopheles gambiae. Although we found little evidence that the orthologues of the multidrug resistance proteins described in other species are associated with resistance in An. gambiae we did identify a subset of ABC proteins consistently differentially expressed in pyrethroid‐resistant populations from across Africa. We present information on the phylogenetic relationship, primary sites of expression and potential role of ABC transporters in mediating the mosquito's response to insecticides. Furthermore we demonstrate that a paralogous group of eight ABCG transporters, clustered on chromosome 3R, are highly enriched in the legs of An. gambiae mosquitoes, consistent with a proposed role for this ABC subfamily in transport of lipids to the outer surface of the cuticle. Finally, antibodies raised against one of the most highly expressed ABC transporters in adult females, ABCG7 (AGAP009850), localized this transporter to the pericardial cells. These data will help prioritize members of this gene family for further localization and functional validation studies to identify the in vivo function of these transporters in the mosquito and determine whether elevated expression of members of this family contribute to insecticide resistance.

DOI : 10.1111/imb.12351

ISSN: 0962-1075
Sayı: 1
Cilt: 27
Sayfa: 110-122

20

Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

H. Ranson , B. Jensen , J. M. Vulule , X. Wang , J. Hemingway , F. H. Collins

Yıl :

2000

H. Ranson

Ek Bilgiler

Kaydet

DOI : 10.1046/j.1365-2583.2000.00209.x

ISSN: 0962-1075
Sayı: 5
Cilt: 9
Sayfa: 491-497

21

Temephos resistance and esterase activity in the mosquito Aedes aegypti in Havana, Cuba increased dramatically between 2006 and 2008

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Medical and Veterinary Entomology

Yazar(lar) :

J. A. BISSET , M. M. RODRÍGUEZ , Y. RICARDO , H. RANSON , O. PÉREZ , M. MOYA , A. VÁZQUEZ

Konu :

Insect Science, Ecology, Evolution, Behavior and Systematics, General Veterinary, Parasitology

Yıl :

2011

H. RANSON

Özet Ek Bilgiler

Kaydet

Aedes aegypti (L.) (Diptera: Culicidae) control programmes in Cuba rely on the application of the organophosphate temephos for larval control. Hence, the monitoring of resistance to this insecticide is an essential component of such programmes. Here, 15 field populations from different municipalities of Havana City were assayed for resistance to temephos. High levels of resistance were detected in all strains and resistance ratios were highly correlated with esterase activity (P = 0.00001). Populations from three municipalities were tested in both 2006 and 2008; resistance and esterase activities both significantly increased during this 2‐year period. Synergist studies demonstrated that neither glutathione transferases nor monooxygenases were associated with the increase in resistance to temephos in this period. The duration of the efficacy of commercial formulations of temephos in controlling Ae. aegypti populations in Havana City was reduced by the high level of temephos resistance observed; hence these data are of clear operational significance for the dengue control programme in Cuba. New integrated strategies to avoid further increases in temephos resistance in Cuba are necessary.

DOI : 10.1111/j.1365-2915.2011.00959.x

ISSN: 0269-283X
Sayı: 3
Cilt: 25
Sayfa: 233-239

22

Molecular analysis of multiple cytochrome P450 genes from the malaria vector, Anopheles gambiae

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

H. Ranson , D. Nikou , M. Hutchinson , X. Wang , C. W. Roth , J. Hemingway , F. H. Collins

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2002

H. Ranson

Özet Ek Bilgiler

Kaydet

Cytochrome P450s are a superfamily of haemoproteins, important in the metabolism of endogenous compounds and xenobiotics. As a first step to elucidating the role of this family in insecticide resistance in the malaria mosquito, Anopheles gambiae, we have cloned and mapped multiple P450 genes. Sixteen cDNAs encoding full‐length P450s were cloned and physically mapped to the mosquito's polytene chromosomes. Fourteen of these encode putative CYP6 proteins and two encode P450s belonging to the CYP9 class. Eighteen new A. gambiae Cyp4 P450 genes were identified using degenerate PCR primers, cDNAs were detected for ten and in situ locations for thirteen members of this gene family.

DOI : 10.1046/j.1365-2583.2002.00350.x

ISSN: 0962-1075
Sayı: 5
Cilt: 11
Sayfa: 409-418

23

Transcriptional analysis of insecticide resistance in Anopheles stephensi using cross-species microarray hybridization

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

J. Vontas , J.-P. David , D. Nikou , J. Hemingway , G. K. Christophides , C. Louis , H. Ranson

Yıl :

2007

H. Ranson

Özet Ek Bilgiler

Kaydet

A large scale microarray (20k MMC1) from the African malaria vector Anopheles gambiae was used to monitor gene expression in insecticide resistant and susceptible strains of the Asian mosquito Anopheles stephensi. Heterologous hybridization at slightly reduced stringency yielded ∼7000 significant signals. Thirty‐six putative genes were differentially transcribed between the pyrethroid‐resistant (DUB‐R) and the susceptible (BEECH) strains. The expression profiles of selected transcripts were verified by real‐time PCR. A gene putatively involved in the thickening of the adult cuticle showed the most striking up‐regulation in DUB‐R. A more specialized microarray containing 231 An. gambiae genes putatively involved in insecticide detoxification was used to further analyse classical insecticide resistance genes. Three glutathione S‐transferase (GST) transcripts, one esterase and a cytochrome P450 were up‐regulated in the resistant strain, while two peroxidases were down‐regulated.

DOI : 10.1111/j.1365-2583.2007.00728.x

ISSN: 0962-1075
Sayı: 3
Cilt: 16
Sayfa: 315-324

24

Metabolic enzymes associated with xenobiotic and chemosensory responses inNasonia vitripennis

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

J. G. Oakeshott , R. M. Johnson , M. R. Berenbaum , H. Ranson , A. S. Cristino , C. Claudianos

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2010

H. Ranson

Özet Ek Bilgiler

Kaydet

The numbers of glutathione S‐transferase, cytochrome P450 and esterase genes in the genome of the hymenopteran parasitoid Nasonia vitripennis are about twice those found in the genome of another hymenopteran, the honeybee Apis mellifera. Some of the difference is associated with clades of these families implicated in xenobiotic resistance in other insects and some is in clades implicated in hormone and pheromone metabolism. The data support the hypothesis that the eusocial behaviour of the honeybee and the concomitant homeostasis of the nest environment may obviate the need for as many gene/enzyme systems associated with xenobiotic metabolism as are found in other species, including N. vitripennis, that are thought to encounter a wider range of potentially toxic xenobiotics in their diet and habitat.

DOI : 10.1111/j.1365-2583.2009.00961.x

ISSN: 0962-1075
Cilt: 19
Sayfa: 147-163

25

Systematic Variation in Willingness to Pay for Aquatic Resource Improvements and Implications for Benefit Transfer: A Meta-Analysis

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie

Yazar(lar) :

Robert J. Johnston , Elena Y. Besedin , Richard Iovanna , Christopher J. Miller , Ryan F. Wardwell , Matthew H. Ranson

Konu :

Agronomy and Crop Science, Ecology, Economics and Econometrics, Animal Science and Zoology, Global and Planetary Change

Yıl :

2005

Matthew H. Ranson

Özet Ek Bilgiler

Kaydet

Researchers are increasingly considering benefit transfer approaches that allow welfare measures to be adjusted for characteristics of the policy context. The validity and reliability of such adjustments, however, depends on the presence of systematic variation in underlying WTP. This paper describes a meta‐analysis conducted to identify systematic components of WTP for aquatic resource improvements. Model results reveal systematic patterns in WTP unapparent from stated preference models considered in isolation, and suggest that observable attributes account for a substantial proportion of the variance in WTP estimates across studies. The analysis also exposes challenges faced in development, estimation, and interpretation of meta‐models for benefit transfer and welfare guidance. These challenges remain salient even in cases where the statistical performance of meta‐models is satisfactory.

DOI : 10.1111/j.1744-7976.2005.04018.x

ISSN: 0008-3976
Sayı: 2-3
Cilt: 53
Sayfa: 221-248

26

Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Insect Molecular Biology

Yazar(lar) :

H. Ranson , M. G. Paton , B. Jensen , L. McCarroll , A. Vaughan , J. R. Hogan , J. Hemingway , F. H. Collins

Konu :

Insect Science, Genetics, Molecular Biology

Yıl :

2004

H. Ranson