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1
The role of H_1tnO_1tn2 as a mediator of UVB induced apoptosis in keratinocytes Elektronische Ressource / von Hong Chang
Tez

Tez
Open Access
Kaynak :
The Dart-Europe
Dergi:
Friedrich-Schiller-Universität Jena
Yazar(lar) :
Hong Chang
Yıl :
2003
Hong Chang
Yayıncı Web Sitesi
Kaydet Alıntıla
Sınıflandırma :
Apoptoz %96
2
The role of HO2 as a mediator of UVB induced apoptosis in keratinocytes Elektronische Ressource / von Hong Chang
Tez

Tez
Open Access
Kaynak :
The Dart-Europe
Dergi:
Friedrich-Schiller-Universität Jena
Yazar(lar) :
Hong Chang
Yıl :
2003
Hong Chang
Yayıncı Web Sitesi
Kaydet Alıntıla
Sınıflandırma :
Apoptoz %96
3
RNAi-mediated knockdown of target genes: a promising strategy for pancreatic cancer research
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
Cancer Gene Therapy
Yayıncı:
Springer Nature
Yazar(lar) :
Hong Chang
Konu :
Biomedicine, general, Gene Therapy, Gene Expression
Yıl :
2007
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Pancreatic cancer is one of the most aggressive malignancies with a very poor prognosis, partially due to its very low accessibility to resection and resistance to chemoradiotherapy. As such, it is reasonable to find more effective, specific therapies and the related therapeutic targets. The identification of certain genes contributing to the tumorigenesis and poor prognosis provides the specific targets for efficient silencing by RNA interference (RNAi). As a powerful tool to suppress gene expression in mammalian cells, RNAi can be directed against pancreatic cancer through various pathways, including the inhibition of overexpressed oncogenes, suppression of tumor growth, metastasis and enhancement of apoptosis. In combination with chemoradiotherapy agents, RNAi can also attenuate the chemoradiation resistance of pancreatic cancer. In addition, RNAi has been used to define the ‘loss of function’ of endogenous genes in pancreatic cancer. This review provides a brief introduction to recent developments of RNAi applications in pancreatic cancer studies and suggestions for further exploration. It substantially demonstrates that RNAi holds a promising therapeutic potential as a future treatment for pancreatic cancer.
DOI : 10.1038/sj.cgt.7701063
ISSN: 1476-5500
Cilt: 14
Sayı: 8
Sayfa: 677-685
Sınıflandırma :
4
Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Molecular Neurobiology
Yazar(lar) :
Hong Chang
Konu :
Neuroscience (miscellaneous), Cellular and Molecular Neuroscience, Neurology
Yıl :
2016
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Genome-wide analysis (GWA) is an effective strategy to discover extreme effects surpassing genome-wide significant levels in studying complex disorders; however, when sample size is limited, the true effects may fail to achieve genome-wide significance. In such case, there may be authentic results among the pools of nominal candidates, and an alternative approach is to consider nominal candidates but are replicable across different samples. Here, we found that mRNA expression of the choline dehydrogenase gene (CHDH) was uniformly upregulated in the brains of bipolar disorder (BPD) patients compared with healthy controls across different studies. Follow-up genetic analyses of CHDH variants in multiple independent clinical datasets (including 11,564 cases and 17,686 controls) identified a risk SNP rs9836592 showing consistent associations with BPD (P meta = 5.72 × 10−4), and the risk allele indicated an increased CHDH expression in multiple neuronal tissues (lowest P = 6.70 × 10−16). These converging results may identify a nominal but true BPD susceptibility gene CHDH. Further exploratory analysis revealed suggestive associations of rs9836592 with childhood intelligence (P = 0.044) and educational attainment (P = 0.0039), a “proxy phenotype” of general cognitive abilities. Intriguingly, the CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous BPD genome-wide association studies (GWAS), but CHDH is lying outside of the core GWAS linkage disequilibrium (LD) region, and our studied SNP rs9836592 is ∼1.2 Mb 3′ downstream of the previous GWAS loci (e.g., rs2251219) with no LD between them; thus, the association observed here is unlikely a reflection of previous GWAS signals. In summary, our results imply that CHDH may play a previously unknown role in the etiology of BPD and also highlight the informative value of integrating gene expression and genetic code in advancing our understanding of its biological basis.
DOI : 10.1007/s12035-016-0041-x
Anahtar Kelimeler : Bipolar disorder, Gene expression, CHDH, Genetic evidence, Expression quantitative trait loci (eQTL), Cognitive ability
ISSN: 0893-7648 1559-1182
Sayı: 7
Cilt: 54
Sayfa: 5166-5176
5
Identification of damage mode in AZ31 magnesium alloy under tension using acoustic emission
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Transactions of Nonferrous Metals Society of China
Yayıncı:
Elsevier
Yazar(lar) :
Hong CHANG
Yıl :
2015
Hong CHANG
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
In order to characterize different damage modes, real-time detection of the tensile cracking process for AZ31 magnesium alloy was performed using acoustic emission (AE) technique. Results showed that elastic deformation, plastic deformation, microcracking, stable and unstable propagation occurred during crack damage. Four damage modes were determined using AE multiparameter analysis. Dislocation motion signals with amplitudes <70 dB and twinning signals with 70–100 dB were found. Microcrack signal energy was concentrated from 2400 aJ to 4100 aJ, mainly at a rise time of less than 800 μs. A stable crack propagation signal had high peak to counts in the 20 to 50 range, whereas its ring count was in the 20 to 2000 range. The average frequency of unstable propagation signals was approximately 100 kHz, with duration from 2000 μs to 105 μs. The damage mechanisms and AE resources from different crack propagation steps were discussed. Various damage modes could be characterized by different AE signal parameters when they appeared simultaneously during crack propagation.
DOI : 10.1016/s1003-6326(15)63790-6
Anahtar Kelimeler : acoustic emission, multi-parameter analysis, damage characterization, tension testing, magnesium alloy
ISSN: 1003-6326
Sayı: 6
Cilt: 25
Sayfa: 1840-1846
Sınıflandırma :
6
Epidemiological features and control of schistosomiasis japonica in China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Memórias do Instituto Oswaldo Cruz.
Yazar(lar) :
Yuan Hong-Chang
Yıl :
1992
Yuan Hong-Chang
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Achievements and successes have been obtained in schistosomiasis control in China. An epidemic survey was carried out and its results analyzed.
DOI : 10.1590/S0074-02761992000800037
Anahtar Kelimeler : schistosomiasis, control, Schistosoma japonicum, epidemiology
Cilt: 87
Sayfa: 241 - 241
Sınıflandırma :
7
Schistosomiasis control in China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Memórias do Instituto Oswaldo Cruz.
Yazar(lar) :
Hong-Chang Yuan
Yıl :
1995
Hong-Chang Yuan
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
After three decades' efforts, schistosomiasis japonica were controlled in one-third (4/12) of endemic provinces and 68.2 (259/380) of endemic counties throughout the country. The remaining 121 endemic counties are located primarily in the lake and mountainous regions. The epidemiological and ecological features of the lake and mountainous areas are different from the other endemic areas. The major schistosomiasis control efforts in China can be characterized as follows: (1) Application of centralized leadership and management, since schistosomiasis control is a task not only of the Ministry of Public Health, but also of all local governments in the endemic areas; (2) Integration of actions taken by various departments or bureaus, such as agriculture, water conservation and public health; (3) Promotion of mass participation; (4) Organization of strong professional teams; (5) Raising sufficient funds. Strategies on schistosomiasis control applied in different areas are divided into three levels: (1) In the areas where the schistosomiasis has been successfully controlled, surveillance must be maintained and immediate action should be taken where new infections occur and/or vector snails are found, so that control can be reestablished quickly; (2) In the areas where schistosomiasis has been partially controlled, any residents and/or live-stock infected should be examined and treated promptly with due care, and environment modifying and/or mollusciding must be used to eliminate the remaining snails; (3) In the areas where transmission has not been controlled, the main strategy is to control morbidity. Mass or selective chemotherapy with praziquental should be applied to both infected persosns and the live-stock, and environment modification for the snail-ridden areas should be taken but should be coordinated with agriculture where possible. Advance cases must be treated; and epidemics of Katayama fever prevented; water supply and sanitation shoud be improved and health education emphasized. Annual mass or selective chemotherapy with praziquental both reduces the prevalence rate and decreases the intensity of the infection for inhabitants and live-stock. As a consequence of the therapy a low prevalence rate can be obtained in a short time. The length of such arrangement period can be decided in accordance with the prevalence of the infection before the drug program is begun. Therefore,a maintenance phase is urgently needed. As China's ecomony expands and people's living standard rises, schistosomiasis will be controlled more effectively and successfully.
DOI : 10.1590/S0074-02761995000200031
Anahtar Kelimeler : schistosomiasis japonica, control, China
Cilt: 90
Sayı: 2
Sayfa: 297 - 301
Sınıflandırma :
8
Modeling of a double-sampling switched-capacitor bandpass delta-sigma modulator for multi-standard applications
Konferans Bildirileri

Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
Hong Chang
Konu :
Components, Circuits, Devices and Systems, Computing and Processing, Communication, Networking and Broadcast Technologies, Signal Processing and Analysis
Yıl :
2011
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This paper presents an improved non-ideal model of a switched-capacitor bandpass delta-sigma modulator with tunable resonators, noise-coupling and 4-bit quantizer. Considering operational amplifier non-ideal effect, clock jitter, noise, double-sampling and multi-bit quantizer capacitor mismatch effect, behavioral simulation in simulink shows that it provides 83.4dB, 67.5dB, 80.2dB, 41.0dB Signal-to-Noise-and-Distortion ratio (SNDR) and 84dB, 68dB, 80dB, 55dB dynamic range (DR) for GSM, WCDMA, TD-SCDMA and WLAN respectively.
DOI : 10.1109/asicon.2011.6157222
Anahtar Kelimeler : Wireless LAN, Multiaccess communication, Frequency modulation, GSM, Spread spectrum communication, Switches, Resonant frequency, band-pass filters, circuit noise, circuit simulation, circuit tuning, clocks, coupled circuits, delta-sigma modulation, jitter, operational amplifiers, switched capacitor networks, double-sampling switched-capacitor bandpass delta-sigma modulator, multistandard application, tunable resonator, noise-coupling, operational amplifier nonideal effect, clock jitter, multibit quantizer capacitor mismatch effect, behavioral simulation, Simulink, signal-to-noise-and-distortion ratio, dynamic range, GSM, WCDMA, TD-SCDMA, WLAN, word length 4 bit, noise figure 83.4 dB, noise figure 67.5 dB, noise figure 80.2 dB, noise figure 41 dB, noise figure 84 dB, noise figure 68 dB, noise figure 80 dB, noise figure 55 dB
9
The Tectonics of China Data, Maps and Evolution By Tianfeng Wan
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Geosciences Journal
Yazar(lar) :
Ki-Hong Chang
Konu :
General Earth and Planetary Sciences, General Environmental Science
Yıl :
2012
Ki-Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s12303-012-0008-5
ISSN: 1226-4806 1598-7477
Sayı: 1
Cilt: 16
Sayfa: 85-89
10
1-48-04 Drug choice of oral medication in carpal tunnel syndrome
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of the Neurological Sciences
Yayıncı:
Elsevier
Yazar(lar) :
Ming-Hong Chang
Yıl :
1997
Ming-Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/s0022-510x(97)85154-4
ISSN: 0022-510X
Cilt: 150
Sayfa: S64
Sınıflandırma :
11
A waveform oriented electric machine testing system aided by personal computer
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Electric Power Systems Research
Yayıncı:
Elsevier
Yazar(lar) :
Cheng-Hong Chang
Yıl :
1995
Cheng-Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This paper presents a personal computer (PC) aided testing system that retrieves rotor speed, voltage, current and power factor of AC (single-phase or three-phase) and DC electric machines and displays them in time domain waveform formats. Taking advantage of the displayed waveform profiles, users are able to achieve a better understanding of electric machines than by using instruments typically adopted in the laboratory. The proposed testing system can be applied not only to ordinary electric machine experiments but also to special-topic studies in the undergraduate laboratory. Both the hardware configuration and software techniques instrumental in building the system are presented.
DOI : 10.1016/0378-7796(94)00910-v
Anahtar Kelimeler : Electric machine testing system, Waveform profile display
ISSN: 0378-7796
Sayı: 2
Cilt: 32
Sayfa: 153-159
Sınıflandırma :
12
Premotor symptoms as predictors of outcome in Parkinson's Disease: A nationwide population-based and case-control study
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Parkinsonism & Related Disorders
Yayıncı:
Elsevier
Yazar(lar) :
Ming-Hong Chang
Yıl :
2016
Ming-Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/j.parkreldis.2015.10.052
ISSN: 1353-8020
Cilt: 22
Sayfa: e37
13
網路虛擬實境與情境學習的整合應用 Application of Internet Virtual Reality and Situated Learning
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Educational Media & Library Sciences
Yazar(lar) :
Chaoyun Liang , Hong Chang
Yıl :
1998
Hong Chang
Tam Metin
Kaydet Alıntıla
無 This article introduces an ongoing project that integrates Internet virtual reality techniques with situated learning theory, and tries to find out the synthesized application. Based upon the synthesis, the authors develop a set of learning materials that can provide an environment for multiple-user participation and real-time interaction on Internet. A detailed description of the instructional design process is offered, followed by the suggestions for future research in this promising area.
Anahtar Kelimeler : Internet, Virtual reality, Internet virtual reality, Situated learning material development
ISSN: 1013-090X
Cilt: 36
Sayı: 2
Sayfa: 197 - 224
14
Flexural Behaviour of Unbonded Posttensioned Concrete Beam Strengthened with Aluminium Alloy Plates
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Mathematical Problems in Engineering
Yazar(lar) :
Hong Chang , Wei Zhou
Yıl :
2020
Hong Chang
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Owing to their high corrosion resistance, aluminium alloy (AA) plates bonded with magnesium phosphate cement (MPC) are considered as a viable candidate for reinforcing inshore infrastructures that are subject to severe environmental conditions and vapor atmospheres. Therefore, the aim of this study is the evaluation of the flexural behaviour of simple beams that are strengthened using this technique. Six unbonded posttensioned concrete (UPC) beams with different reinforcement ratios are damaged by static loads and then repaired and strengthened using AA plates. The failures under two-point loading are then investigated. Thereafter, a simplified method is proposed for the evaluation of the flexural strength of a UPC beam strengthened by an AA plate with MPC. The flexural strengths of the six specimens increase by an average of 14%, and the displacement ductility factor decreases by an average of 34.14%. Moreover, the increase and decrease ratios are proportional and inversely proportional to the comprehensive reinforcement index, respectively. The influences of the three main factors on the flexural strength of the AA plate are determined: the increase in the stress of the unbonded tendons, stress at the midspan and slippage at the ends of the AA plate, and increase ratio of the flexural strength. It shows that the AA plates bonded with MPC can be used successfully in concrete strengthening.
DOI : 10.1155/2020/6535609
Cilt: 2020
Sınıflandırma :
15
Megakaryocytic emperipolesis in a therapy‐related acute‐mixed phenotypic leukemia
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Laboratory Hematology
Yazar(lar) :
Serge Koujanian , Hong Chang
Yıl :
2022
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/ijlh.13796
ISSN: 1751-5521
16
Magnetic and transport properties of electron-doped Ca3−x Bi x Mn2O7
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Applied Physics A
Yazar(lar) :
Hong Chang , Qiang Wu
Konu :
General Materials Science, General Chemistry
Yıl :
2013
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Ca3−x Bi x Mn2O7 with the nominal composition x=0.05, 0.1, 0.2 and 0.3 is synthesized by solid-state reaction. The refined X-ray diffraction pattern of Ca2.807Bi0.193Mn2O7 with the nominal Bi3+ content x=0.2 indicates that about 71 % of the Bi3+ ion enters into the Ca2+ (2a) site and the remaining 29 % is in the Ca2+ (4e) site. The doped Bi3+ ion produces a ferromagnetic component in the antiferromagnetic matrix. Below the transition temperature, at about 110 K, the ferromagnetic and antiferromagnetic interactions coexist. The alignment of the magnetic moment is canted at 5 K. The electric transport shows insulating behavior. Around the magnetic transition, at about 110 K, the resistance sharply drops like a well. A model proposed by Glazman and Matveev (GM model) is applied to the thermal variation of the resistance from 40 K to 138 K. Above this temperature, it is due to thermally activated hopping of small polarons with the activation energy of 50 meV. A negative magnetoresistance, 17 %, is observed with the doping content as low as 0.05. The magnetoresistance is due to the spin-polarized inelastic tunneling through nonmagnetic localized states embedded in an insulating barrier.
DOI : 10.1007/s00339-013-7991-x
Anahtar Kelimeler : Mn2O7, Double Exchange, Negative Magnetoresistance, Electron Doping, Quantum Design Squid Magnetometer
ISSN: 0947-8396 1432-0630
Sayı: 4
Cilt: 115
Sayfa: 1323-1327
17
The possible climate impact on the collapse of an ancient urban city in Mu Us Desert, China
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Regional Environmental Change
Yazar(lar) :
Jianxin Cui , Hong Chang
Konu :
Global and Planetary Change
Yıl :
2012
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Tongwan City is one of the most famous and best-researched archaeological sites in China. By using palaeoclimatology proxy records from China over the last 2,000 years and archaeological/historical documents, we analyse the possible effect of climate on the collapse of Tongwan City, an ancient urban city of the Daxia state (AD 407–427). During Tongwan City’s existence (AD 413–994), two severe cold and drought stages were recorded by both natural proxy data and the synthesis compiled from the historical documents. The first cold and drought stage occurred at about AD 420–550, with the lowest point centred at about AD 500. The second cold and drought stage occurred at about AD 780–950. These periods correspond to the times of climate deterioration, especially weak summer monsoons, which eventually resulted in the intensive desertification and collapse of Tongwan City.
DOI : 10.1007/s10113-012-0345-y
Anahtar Kelimeler : Tongwan City, Climate impact, Mu Us desert, Historical documents, Proxy records, Archaeological site
ISSN: 1436-3798 1436-378X
Sayı: 2
Cilt: 13
Sayfa: 353-364
18
Effects of Formulat Bushenzhuanggu on the biochemical markers of bone metabolism and the bone mineral density in ovariectomized rats
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Yazar(lar) :
Yan Liu , Hong Chang
Yıl :
2010
Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/j.bone.2010.09.215
ISSN: 8756-3282
Cilt: 47
Sayfa: S413
Sınıflandırma :
19
Research Progress and Practice of Ecology Problems on Information Systems
Konferans Bildirileri

Konferans Bildirileri
Kaynak :
IEEE Xplore
Yazar(lar) :
Hong-chang An
Konu :
General Topics for Engineers, Computing and Processing, Communication, Networking and Broadcast Technologies
Yıl :
2010
Hong-chang An
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Information Systems (or computer-based information systems) have begun to turn simplicity to complexity and turn hard-to-use to easy-to-use. However, effectiveness and efficiency on computer-based information systems is not satisfying yet. In order to keep information ecology (which has been complex and which information systems ecology belongs to) balance, computer-based information systems ecology and effectiveness and efficiency on computer-based information systems should be paid more attention. The paper mainly analyzes computer-based information systems problems from an ecological perspective to make people scientifically and comprehensively understand information systems and seek for better solutions to development and use of information systems. Computer software ecology is the most complex among the four ecologies (computer software ecology, computer hardware ecology, computer talents ecology and information surroundings ecology which information systems ecology involves), and has bigger effect on information systems ecology and information ecology than the other three. Computer software ecology is mainly discussed in the paper.
DOI : 10.1109/ic4e.2010.131
Anahtar Kelimeler : Environmental factors, Information systems, Management information systems, Humans, Ecosystems, Information analysis, Evolution (biology), Organisms, Software systems, Hardware, information systems, software management, computer based information systems, ecological perspective, computer software ecology, computer hardware ecology, computer talents ecology, software project management, information systems, ecological perspective, information systems ecology, software ecology, software project management
20
Efficient differential code bias and ionosphere modeling and their impact on the network-based GPS positioning
Tez

Tez
Open Access
Kaynak 1:
OhioLINK
Kaynak 2:
ORA Thesis
Dergi:
The Ohio State University
Yayıncı:
The Ohio State University
Yazar(lar) :
Hong Chang-Ki
Konu :
Geodesy
Yıl :
2007
Hong Chang-Ki
Tam Metin
Kaydet Alıntıla
One of the major error sources in using Global Positioning System (GPS) measurements for modeling the ionosphere is the receiver differential code bias (DCB). Therefore, the determination of the receiver DCB is important, and to date, it has been done mostly using the single-layer ionospheric model assumption. In this dissertation, a new and efficient algorithm using the geometry conditions between the satellite and the tracking receivers is proposed to determine the receiver DCB using permanent reference stations. In this method, an assumption that ionosphere is represented by a single-layer model is not required, which makes DCB computation independent on the pre-selected ionosphere model. In addition, this method is simple, accurate and computationally efficient. The principal idea is that the magnitude of the signal delay caused by the ionosphere is, under normal conditions, highly dependent on the geometric range between the satellite and the receiver. The proposed algorithm was tested with the Ohio Continuously Operating Reference Stations (CORS) and the Transantarctic Mountains Deformation (TAMDEF) sub-network data. The results show that quality comparable to the traditional DCB estimation method is obtainable with greater computational efficiency and simple algorithmic implementation.
Anahtar Kelimeler : GPS, GPS remote sensing, GPS positioning, ionosphere modeling
Tez Türü: PhD thesis
Sayfa: 0 - 221
Sınıflandırma :
21
Synthesis and Structural Characterization of the Sodium Salt of a New Sulfonate-containing Water Soluble N-Donor Ligand⎯ Self-assembly in the Solid State by π−π Stacking Interactions
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Molecules
Yazar(lar) :
Hong-Chang Liang , Yonglian Zhang
Yıl :
2006
Hong-Chang Liang
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
The synthesis, spectroscopic characterization, and X-ray crystal structure ofthe sodium salt of a new sulfonated water-soluble ligand, sodium 2-(2-pyridin-2-yl-ethylamino)-benzenesulfonate (L) are described. Compound L crystallizes in thecentrosymmetric space group Pbcn, orthorhombic, a=31.930(13) å, b=7.153(3) å,c=14.193(6) å, α=90.00, β=90.00, γ=90.00, V=3220(2) å3, Z=9. π−π stacking contactsinvolving interactions between the π-donor benzene and the π-acceptor pyridine systemsreinforce and direct the self-assembly of the structural motifs in the solid state.
DOI : 10.3390/11020163
Anahtar Kelimeler : Sulfonate, Water-soluble Ligand, Ãu008FÂu20ACâˆÂu2019Ãu008FÂu20AC Stacking, Michael-type Addition.
ISSN: 1420-3049
Cilt: 11
Sayı: 2
Sayfa: 163 - 168
Sınıflandırma :
22
Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Scientific Reports
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
Melanie L. Lawrence , C-Hong Chang , Jamie A. DaviesMelanie L. Lawrence , C-Hong Chang , Jamie A. Davies
Yıl :
2015
C-Hong Chang C-Hong Chang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1038/srep09092
ISSN: 2045-2322
Sayı: 1
Cilt: 5
23
Bayesian and Frequentist Confidence Intervals Arising from Empirical-Type Likelihoods
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Biometrika
Yayıncı:
Oxford University Press
Yazar(lar) :
In Hong Chang , Rahul Mukerjee
Konu :
Science & Mathematics, Statistics
Yıl :
2008
In Hong Chang
Yayıncı Web Sitesi
Kaydet Alıntıla
For a general class of empirical-type likelihoods for the population mean, higher-order asymptotics are developed with a view to characterizing its members which allow, for any given prior, the existence of a confidence interval that has approximately correct posterior as well as frequentist coverage. In particular, it is seen that the usual empirical likelihood always allows such a confidence interval, while many of its variants proposed in the literature do not enjoy this property. An explicit form of the confidence interval is also given.
Cilt: 95
Sayı: 1
Sayfa: pp. 139-147
Yayın Tarihi: 2008-03-01
ISSN: 0006-3444
24
Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2Highreceptors: D2 basis for schizophrenia
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Synapse
Yazar(lar) :
Philip Seeman , Hong-Chang Guan
Konu :
Cellular and Molecular Neuroscience
Yıl :
2008
Hong-Chang Guan
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
It has previously been reported that the glutamate ionotropic antagonist phencyclidine directly inhibits the release of prolactin in anterior pituitary cells in culture, suggesting that phencyclidine has a dopamine (DA)‐like action on prolactin‐releasing cells. It has also been reported that the glutamate metabotropic agonist LY379268 can stimulate the incorporation of [35S]GTP‐γ‐S into DA D2Long receptors. The present study was done to examine whether such glutamatergic drugs had similar actions on the DA D2Short receptor. The present results show that phencyclidine, ketamine, and LY379268 also stimulated the incorporation of [35S]GTP‐γ‐S into D2Short receptors. The proportion of D2Long and D2Short receptors existing in the high‐affinity state were both markedly reduced by NaCl. While phencyclidine and LY379268 each stimulated the incorporation of GTP‐γ‐S into D2Long and D2Short receptors, this stimulation was reduced by NaCl, with D2Short being much more sensitive than D2Long to the inhibition by NaCl. The binding of phencyclidine and LY379268 to D2High receptors in vivo was directly confirmed by the i.v. injection of phencyclidine and LY379268 in which 50% inhibited the binding of [3H]PHNO to the striatum ex vivo at 0.25 and 1.5 mg/kg, respectively. The results confirm that glutamate agonists and antagonists have a significant affinity for DA D2High receptors. The psychotogenic action of phencyclidine may stem from a combination or synergistic action of glutamate receptor antagonism and DA D2 agonism. In addition, the antipsychotic clinical action of LY379268 congeners such as LY404039 may be related to a combined or synergistic action of glutamate receptor stimulation together with a partial DA agonist action that reduces endogenous DA neurotransmission. Synapse 62:819–828, 2008. © 2008 Wiley‐Liss, Inc.
DOI : 10.1002/syn.20561
ISSN: 0887-4476
Sayı: 11
Cilt: 62
Sayfa: 819-828
25
The importance of nurse monitoring for potential opioid abuse in their patients
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Applied Biobehavioral Research
Yazar(lar) :
Theresa Mallick-Searle , Hong Chang
Konu :
Experimental and Cognitive Psychology, Social Sciences (miscellaneous), Cultural Studies, Clinical Psychology
Yıl :
2018
Hong Chang
Yayıncı Web Sitesi
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Deaths related to opioids have quadrupled since 1999, making it a top priority in health care. This article will provide an overview of the opioid crisis, focusing on the role that nurses play in addressing this crisis, with emphasis on assessment, early recognition, and prevention of opioid misuse. Systematic review of Medline, PubMed, and Google Scholar for articles relating to nurses’ role in pain management, education, and safe opioid use. Research suggests the incidence of ongoing, persistent pain is at an all‐time high (IOM Report, 2011, Relieving pain in America: A blueprint for transforming prevention, care, education, and research, The National Academies Press, Washington, DC), coincidently the rate of opioid prescribing over the past 15 years has also reached an all‐time high (Prescription Opioid Overdose Data, 2017, https://www.cdc.gov/drugoverdose/data/overdose.html/). An “opioid crisis” was declared, calling for safer opioid prescribing (CDC Guideline for Prescribing, 2016, https://www.cdc.gov/mmwr/volumes/65/rr/rr6501e1.htm/). Further research shows that nurses are educated and accomplished health care professionals (ASPMN, 2017, The core curriculum for pain management nursing, Elsevier, New York, NY; DEA Requirements, 2017, https://www.deadiversion.usdoj.gov/pubs/docs/dwp_buprenorphine.htm/; Ray & Behr, Clinical Nurse Specialist, 31, 2017, 115; St. Marie, Pain Management Nursing, 17, 2016, 311), at the forefront of monitoring for addiction and opioid misuse. Nurses contribute greatly to enhanced pain assessment and education to patients, families, and their peers. With the current opioid crisis, nurses have taken on the added responsibility of monitoring for potential opioid abuse, safety, and signs of addiction in their patients.
DOI : 10.1111/jabr.12129
ISSN: 1071-2089
Sayı: 1
Cilt: 23
Sayfa: e12129
26
One step forward to a sustainable green solution for extruded foam PVC building products
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Vinyl and Additive Technology
Yazar(lar) :
Hong Chang , Nidal Abu-Zahra
Konu :
Marketing, Materials Chemistry, General Chemistry, General Chemical Engineering, Polymers and Plastics
Yıl :
2011
Hong Chang
Yayıncı Web Sitesi
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This paper is dedicated to the development of a robust and cost‐effective formulation to maximize the use of recycled poly(vinyl chloride) (PVC) back into its virgin compounds. This study concludes that a balanced stabilizer and lubricant formulation will overcome the detrimental effects of repeated heat history on the recycled/regrind PVC. The developed formulation using up to 70% of recycled/regrind PVC has been successfully implemented in the extrusion process for manufacturing high‐quality foam PVC profiles for the building industry. As a result, this study takes a huge step forward toward a green and sustainable solution for PVC applications. J. VINYL ADDIT. TECHNOL., 2011. © 2011 Society of Plastics Engineers
DOI : 10.1002/vnl.20255
ISSN: 1083-5601
Sayı: 1
Cilt: 17
Sayfa: 17-20
27
Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2Highreceptor
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Synapse
Yazar(lar) :
Philip Seeman , Hong-Chang Guan
Konu :
Cellular and Molecular Neuroscience
Yıl :
2009
Hong-Chang Guan
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The glutamate agonist LY404,039 has been used to treat schizophrenia. Because all currently used antipsychotics act on dopamine receptors, it was decided to examine whether this glutamate agonist also had an affinity for dopamine D2 receptors in vitro. The present data show that LY404,039 inhibited the binding of [3H]domperidone and [3H](+)PHNO by 15.5 ± 1.5% to the high‐affinity state, D2High, of cloned dopamine D2Long receptors and rat striatal tissue with dissociation constants of between 8.2 and 12.6 nM. This high‐affinity component of LY404,039 on the binding of [3H]domperidone was inhibited by the presence of guanine nucleotide, indicating an agonist action of the drug at D2High. LY404,039 also stimulated the incorporation of [35S]GTP‐γ‐S into D2Long receptors (EC50% = 80 ± 15 nM) over the same range of concentrations as occurred for the inhibition of [3H]domperidone by LY404,039 at D2High (IC50%High = 50 ± 10 nM). A possible clinical antipsychotic action of LY404,039 may depend on the combined stimulation of glutamate receptors and a partial dopamine agonist action that would interfere with neurotransmission at D2High receptors. Synapse 63:935–939, 2009. © 2009 Wiley‐Liss, Inc.
DOI : 10.1002/syn.20704
ISSN: 0887-4476
Sayı: 10
Cilt: 63
Sayfa: 935-939
28
Glutamate agonists for treating schizophrenia have affinity for dopamine D2Highand D3 receptors
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Synapse
Yazar(lar) :
Philip Seeman , Hong-Chang Guan
Konu :
Cellular and Molecular Neuroscience
Yıl :
2009
Hong-Chang Guan
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Although the glutamate agonist LY 404,039 has been used to treat schizophrenia, its closest congener LY 379,268 has an affinity for both glutamate and dopamine (DA) D2High receptors. Considering that all antipsychotics act on dopamine receptors, and considering that another laboratory reported that LY 379,268 did not have any affinity for the D2High receptor, it was necessary to examine whether such glutamate agonists have an affinity for D2 and D3 dopamine receptors in vitro. The present data show that 50–200 nM LY 379,268 inhibited the binding of [3H]domperidone and [3H](+)PHNO to cloned dopamine D2 receptors consistently and reproducibly by 16% with dissociation constants of 2.1 and 2.5 nM at D2High, respectively. In addition, LY 379,268 inhibited the binding of [3H]domperidone and [3H](+)PHNO to cloned dopamine D3 receptors with dissociation constants of 130 and 10 nM, respectively. LY 379,268 also inhibited the binding of [3H]domperidone to rat striata with a dissociation constant of 22 nM, predicting a clinical antipsychotic dose of 80–100 mg/day. LY 379,268 appears to act as an agonist at D2High and as an antagonist at D3, because guanine nucleotide eliminated the competition at D2High but had no effect on the competition at D3. The findings indicate that this type of glutamate agonist, LY 379,268, has a significant affinity for D2High and D3 receptors. Synapse 63:705–709, 2009. © 2009 Wiley‐Liss, Inc.
DOI : 10.1002/syn.20673
ISSN: 0887-4476
Sayı: 8
Cilt: 63
Sayfa: 705-709
29
Implant dentistry in China: Progress and innovation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Clinical Implant Dentistry and Related Research
Yazar(lar) :
Hongu2010Chang Lai , Ye Lin
Konu :
Oral Surgery, General Dentistry
Yıl :
2019
Hong‐Chang Lai
Yayıncı Web Sitesi
Tam Metin
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DOI : 10.1111/cid.12788
ISSN: 1523-0899
Sayı: 3
Cilt: 21
Sayfa: 427-427
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