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1
Baseband Video Transmission on Loops and Short-Haul Trunks
Dergi Makalesi

Dergi Makalesi
Kaynak :
IEEE Xplore
Dergi:
Bell System Technical Journal
Yazar(lar) :
J. M. Brown
Konu :
Communication, Networking and Broadcast Technologies
Yıl :
1971
J. M. Brown
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Local Picturephone® service will be provided using present telephone cable facilities. Three cable pairs are required for each Picturephone call, one for audio and two for video transmission. Underground cables will be used extensively and aerial facilities to a limited extent. A cable equaliser will provide shaped gain to compensate for cable loss from 5 Hz to 1 MHz. This article discusses the plan for providing baseband video transmission on paired cable facilities, the cable equalizer design features, the important rules for engineering the video transmission system, and the maintenance features.
DOI : 10.1002/j.1538-7305.1971.tb01864.x
ISSN: 0005-8580
Sayı: 2
Cilt: 50
Sayfa: 395-425
2
Facilitating secure mail in a high assurance LAN
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
Monterey, California. Naval Postgraduate School
Yayıncı:
Monterey, California. Naval Postgraduate School
Yazar(lar) :
Emma J M Brown
Yıl :
2000
Emma J M Brown
Tam Metin
Kaydet Alıntıla
Currently, almost all DoD systems are operated at a single level, classified or unclassified. The problems encountered on these single level systems with mail exchange, its storage, and manipulation are the multiple networks and workstations required to handle different security levels of data as well as the high cost of maintaining them. The Naval Postgraduate School Multilevel Secure Local Area Network (MLS LAN) project supports a high assurance server. This LAN is COTS-driven (commercial-off-the-shelf) and enforces a mandatory security policy while permitting users to employ standard office productivity tools on standard workstations. Initially, there was no means for multilevel mail exchange between clients of the system. This research was to implement the simple mail transfer protocol (SMTP) server, Sendmail, on the Wang Federal XTS 300 as a multilevel server. A port of a UNIX version of Sendmail 8. 9.3 was made to the XTS 300. Modifications to Sendmail were required so that it could be supported by the UNIX-like XTS 300 STOP 4.4.2 operating system Sendmail proved to be a successful mail server for exchange of mail between system clients. Tests demonstrated successful transmission of simple mail and mail with attachments.
Sayfa sayısı :98
Sınıflandırma :
3
An Electro‐Optical Temperature Controller for Maintaining a Constant or Relative Temperature 1
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Agronomy Journal
Yazar(lar) :
J. M. Brown
Konu :
Agronomy and Crop Science
Yıl :
1975
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.2134/agronj1975.00021962006700020029x
ISSN: 0002-1962
Sayı: 2
Cilt: 67
Sayfa: 280-281
4
Comparison of pain from insertion of venous cannulae; a volunteer study
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Anaesthesia
Yazar(lar) :
J. M. Brown
Yıl :
1998
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The pain from insertion of two small cannulae was compared in 26 volunteers. Each subject was blindfolded and had both a 22G and a 20G cannula inserted in random order. One subject was rejected as cannulation was unsuccessful. Of the remaining 25 subjects, 12 found the 22G more painful and 13 the 20G. This difference was not significant (chi squared p > 0.1).
DOI : 10.1046/j.1365-2044.1998.00331.x
ISSN: 0003-2409
Sayı: 5
Cilt: 53
Sayfa: 495-496
5
Selective Homogeneous and Heterogeneous Catalysis
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Ciba Foundation Symposium 53 - Further Perspectives in Organic Chemistry
Yayıncı:
John Wiley & Sons, Ltd.
Yazar(lar) :
J. M. Brown
Yıl :
2008
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/9780470720349.ch10
ISSN: 1935-4657
ISBN:9780444900012
Sayfa: 149-173
6
ChemInform Abstract: ORGANO-LITHIUMREAGENTIEN BEI SYNTH., IHRE MODIFIZIERUNG UND AUSWERTUNG
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Chemischer Informationsdienst
Yazar(lar) :
J. M. BROWN
Yıl :
1972
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.197235352
ISSN: 0009-2975
Sayı: 35
Cilt: 3
Sayfa: no-no
7
ACUTE RETROPHARYNGEAL ABSCESSES IN CHILDREN
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
The Laryngoscope
Yazar(lar) :
J. M. Brown
Konu :
Otorhinolaryngology
Yıl :
1919
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1288/00005537-191901000-00003
ISSN: 0023-852X
Sayı: 1
Cilt: 29
Sayfa: 9???12
8
ATYPICAL MASTOIDITIS???CASE REPORT
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
The Laryngoscope
Yazar(lar) :
J. M. Brown
Konu :
Otorhinolaryngology
Yıl :
1924
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1288/00005537-192408000-00007
ISSN: 0023-852X
Sayı: 8
Cilt: 34
Sayfa: 644???646
9
Frontal sinusitis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
The Laryngoscope
Yazar(lar) :
J. M. Brown
Konu :
Otorhinolaryngology
Yıl :
1946
J. M. Brown
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/lary.5540560303
ISSN: 0023-852X
Sayı: 3
Cilt: 56
Sayfa: 116-119
10
ChemInform Abstract: Asymmetric Homogeneous Catalysis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
ChemInform
Yazar(lar) :
J. M. BROWN
Yıl :
1989
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.198928365
ISSN: 0931-7597
Sayı: 28
Cilt: 20

11
ChemInform Abstract: REACTIVITY AND SELECTIVITY IN CATALYSIS BY RHODIUM COMPLEXES
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Chemischer Informationsdienst
Yazar(lar) :
J. M. BROWN
Yıl :
1983
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.198306360
ISSN: 0009-2975
Sayı: 6
Cilt: 14

12
ChemInform Abstract: OXO CARBOXYLIC ACIDS
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Chemischer Informationsdienst
Yazar(lar) :
J. M. BROWN
Yıl :
1979
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.197948368
ISSN: 0009-2975
Sayı: 48
Cilt: 10

13
ChemInform Abstract: Selectivity and Mechanism in Catalytic Asymmetric Synthesis.
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
ChemInform
Yazar(lar) :
J. M. BROWN
Yıl :
2010
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.199322283
ISSN: 0931-7597
Sayı: 22
Cilt: 24
Sayfa: no-no
14
Conscience: the professional and the personal
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Nursing Management
Yazar(lar) :
J. M. BROWN
Konu :
Leadership and Management
Yıl :
1996
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/j.1365-2834.1996.tb00046.x
ISSN: 0966-0429
Sayı: 3
Cilt: 4
Sayfa: 171-177
15
ChemInform Abstract: Directed Homogeneous Hydrogenation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
ChemInform
Yazar(lar) :
J. M. BROWN
Yıl :
1987
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.198724357
ISSN: 0931-7597
Sayı: 24
Cilt: 18

16
Regional variation in kwongan in the central wheatbelt of south-western Australia
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Austral Ecology
Yazar(lar) :
J. M. BROWN
Konu :
Ecology, Ecology, Evolution, Behavior and Systematics
Yıl :
1989
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This study examined the floristic variation at 20 sites of sclerophyllous shrubland (kwongan) occurring on lateritic soils in the central wheatbelt of south‐western Australia. The results show that this kwongan is as floristically rich and varied as the kwongan in the northern and southern sandplain areas of the south‐west. Six sequential groups of sites can be identified along the rainfall gradient present over the study area; 29 species are selected as indicators of the floristic groups. The distribution of many of the remaining 426 species suggests a continuum of floristic change along the rainfall gradient. One hundred and forty‐five species were only recorded once and thus contributed to the high species richness of the sites and the low level of floristic uniformity between the stands. There were significant trends in the proportions of lifeforms with respect to the rainfall gradient. Evidence of the response of the plants to an obvious environmental gradient and the increased understanding of this complex vegetation type will provide conservation managers with some rationale for setting priorities for reserve acquisition and management.
DOI : 10.1111/j.1442-9993.1989.tb01443.x
ISSN: 1442-9985
Sayı: 3
Cilt: 14
Sayfa: 345-355
17
ChemInform Abstract: Chirality Recognition in Synthesis: Catalytic Kinetic Resolution
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
ChemInform
Yazar(lar) :
J. M. BROWN
Yıl :
1989
J. M. BROWN
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/chin.198909345
ISSN: 0931-7597
Sayı: 9
Cilt: 20

18
Fish communities near municipal wastewater discharges in the Grand River watershed
Tez

Tez
Open Access
Kaynak :
NDTLD Thesis
Dergi:
Global ETD Search
Yayıncı:
Global ETD Search
Yazar(lar) :
Carolyn J M Brown
Yıl :
2010
Carolyn J M Brown
Kaydet Alıntıla
Municipal wastewater effluent (MWWE) has the potential for aquatic degradation, as it is the largest, per volume, anthropogenic discharge in Canada and other areas in the world. With an increasing population in many areas, such as Southern Ontario, there is concern that infrastructure of wastewater treatment facilities will not be able to maintain adequate treatment and prevent further degradation of the environment. The Grand River watershed, in Southern Ontario, is predicted to have its population increase to 1.2 million people by 2031 (from 780,000 people in 2001). Although wastewater treatment has improved, concern remains for receiving environments due to inadequate treatment (i.e. Kitchener) and minimal dilution (i.e. Guelph). This research was conducted to understand current impacts of MWWE in the Grand River watershed on fish communities to support future management and protection. Study sites upstream and downstream were chosen for their proximity to the Guelph, Kitchener, and Waterloo MWWE outfalls, similarity in habitat, and wadeability. Habitat analysis indicated that there were no large physical differences among sites. Fish communities were collected in a standardized method with a backpack electroshocker at each site (six randomly selected 10 m by 10 m sub-sites for 5 min). Greenside Darter (Etheostoma blennioides) and Rainbow Darter (E. caeruleum), the most abundant species, were also analyzed for stable isotope signatures (δ13C and δ15N) at each site. Downstream of the Guelph outfall there were no changes in mean total catch per unit effort (CPUE) or mean total mass. Changes to diversity, resilience, and tolerance in the fish community were attributed to a decreased abundance of Greenside Darter and increased abundance of Rainbow Darter. Downstream of the Kitchener discharge, there was a trend towards decreasing mean total CPUE, especially for darter species, and an increase in mean total mass due to a community shift to larger species including Catostomids and Centrarchids. The changes in abundance of Rainbow Darter, Catostomids, and Centrarchids among reference and Kitchener MWWE exposed sites explained the pattern in resilience, tolerance, and diet classifications. Lower diversity downstream of all three MWWE outfalls can be attributed to the increase in Rainbow Darter abundance. Stable isotope signatures (δ13C and δ15N) of Greenside Darter did not change downstream of the Guelph and Waterloo discharges, but signatures of Rainbow Darter increased immediately below the two outfalls. This shift may be due to the Rainbow Darter being able to take advantage of a change in the environment (i.e. food availability), resulting in its increased abundance and changes in isotopic signature. Directly downstream of the Kitchener outfall both darter species had an increase in δ13C and a large decrease in δ15N, likely due to high nutrient inputs from the outfall. The Kitchener wastewater discharge is also associated with a decrease in abundance of fish and a shift in community structure. MWWEs are currently affecting the aquatic environment, including fish communities in the Grand River watershed. Future investments in infrastructure and watershed management should be made to mitigate degradation of water quality in this watershed.
Anahtar Kelimeler : municipal wastewater effluent, fish communities, stable isotope analysis, Grand River, Rainbow Darter, Greenside Darter, Biology
Sınıflandırma :
19
Looking for evidence of climate change impacts in the eastern Irish Sea
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Natural Hazards and Earth System Sciences
Yazar(lar) :
L. S. Esteves , J. J. Williams , J. M. Brown
Yıl :
2011
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Although storminess is often cited as a driver of long-term coastal erosion, a lack of suitable datasets has only allowed objective assessment of this claim in a handful of case studies. This reduces our ability to understand and predict how the coastline may respond to an increase in "storminess" as suggested by global and regional climate models. With focus on 16 km of the Sefton coastline bordering the eastern Irish Sea (UK), this paper analyses available measured datasets of water level, surge level, wave height, wind speed and barometric pressure with the objective of finding trends in metocean climate that are consistent with predictions. The paper then examines rates of change in shoreline position over the period 1894 to 2005 with the aim of establishing relationships with climatic variability using a range of measured and modelled metocean parameters (with time spans varying from two to eight decades). With the exception of the mean monthly wind speed, available metocean data do not indicate any statistically significant changes outside seasonal and decadal cycles. No clear relationship was found between changes in metocean conditions and rates of shoreline change along the Sefton coast. High interannual variability and the lack of long-term measurements make unambiguous correlations between climate change and shoreline evolution problematic. However, comparison between the North Atlantic Oscillation winter index (NAOw) and coastline changes suggest increased erosion at times of decreasing NAOw values and reduced erosion at times of increasing NAOw values. Erosion tends to be more pronounced when decreasing NAOw values lead to a strong negative NAO phase. At present, anthropogenic changes in the local sediment budget and the short-term impact of extreme events are still the largest threat likely to affect coastal flooding and erosion risk in the short- and medium-term. Nevertheless, the potential impacts of climate change in the long-term should not be ignored.
DOI : 10.5194/nhess-11-1641-2011
Cilt: 11
Sayı: 6
Sayfa: 1641 - 1656
Sınıflandırma :
20
A century of sea level data and the UK's 2013/14 storm surges: an assessment of extremes and clustering using the Newlyn tide gauge record
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Ocean Science
Yazar(lar) :
M. P. Wadey , I. D. Haigh , J. M. Brown
Yıl :
2014
J. M. Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
For the UK's longest and most complete sea level record (Newlyn), we assess extreme high waters and their temporal clustering; prompted by the 2013/2014 winter of storms and flooding. These are set into context against this almost 100-year record. We define annual periods for which storm activity and high sea levels can be compared on a year-by-year basis. Amongst the storms and high tides which affected Newlyn, the recent winter produced the largest recorded high water level (3 February 2014) and five other high water events above a 1 in 1-year return period. The large magnitude of tide and mean sea level, and the close inter-event spacings (of large return period high waters), suggests that the 2013/2014 extreme high water level "season" can be considered the most extreme on record. However, storm and sea level events may be classified in different ways. For example, in the context of sea level rise (which we calculate linearly as 1.81 ± 0.1 mm yr−1 from records between 1915 to 2014), a lower probability combination of surge and tide occurred on 29 January 1948, whilst the 1995/1996 storm surge season saw the most high waters of ≥ the 1 in 1-year return period. We provide a basic categorisation of the four types of extreme high water level cluster, ranging from consecutive tidal cycles to multiple years. The assessment is extended to other UK sites (with shorter sea level records and different tide-surge characteristics), which suggests 2013/2014 was particularly unusual. Further work will assess clustering mechanisms and flood system "memory".
DOI : 10.5194/os-10-1031-2014
Cilt: 10
Sayı: 6
Sayfa: 1031 - 1045
Sınıflandırma :
21
Loop Plant Electronics: The Loop Switching System
Dergi Makalesi

Dergi Makalesi
Kaynak :
IEEE Xplore
Dergi:
Bell System Technical Journal
Yazar(lar) :
N. G. Avaneas , J. M. Brown
Konu :
Communication, Networking and Broadcast Technologies
Yıl :
1978
J. M. Brown
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
A new system for achieving more efficient use of cable pairs, the Loop Switching System (LSS), has been developed which uses a microcomputer to control the call processing, traffic measurement and display, system maintenance, and manual testing. The LSS, which works with any central office, switches 96 subscriber lines onto 32 voice frequency trunk pairs by means of a graded multiple space division switching network at the remote terminal (RT) and expands the trunks back into the individual line appearances at the central office terminal (COT) located within a central office. An additional 96 lines and 32 trunks can be added to the LSS, either at the same RT or a second RT on a different cable route, using the same COT common control equipment. Control of the RT is via two standard voice-frequency pairs used for a full-duplex data link. This four-wire data link, operating at 1250 bits per second, is used to transmit concentrator connection orders from the COT to the RT, service request information from the RT to the COT, and other information pertaining to LSS maintenance and alarms. This paper describes the system features, operational characteristics, and circuit designs used in the LSS system.
DOI : 10.1002/j.1538-7305.1978.tb00624.x
ISSN: 0005-8580
Sayı: 4
Cilt: 57
Sayfa: 1157-1183
22
Host treatments affecting artificial pulmonary metastases: interpretation of loss of radioactively labelled cells from lungs
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
British Journal of Cancer
Yayıncı:
Springer Nature
Yazar(lar) :
J M Brown , E T Parker
Konu :
Biomedicine, general, Cancer Research, Epidemiology, Molecular Medicine, Oncology, Drug Resistance
J M Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The effect has been examined of various host treatments (C. parvum injection, immunization, thoracic irradiation, cyclophosphamide injection, and anticoagulation) on both lung colony formation and clearance of radioactive cells from the lungs after i.v. injection of tumour cells. Two tumour-host models have been used: the non-immunogenic KHT tumour in C3H/Km mice, and the immunogenic EMT6 tumour in BALB/c/Ka mice. Even for the at most weakly immunogenic KHT tumour, the number of artificial pulmonary metastases could be modified by a factor of up to 10(4) by different host treatments before i.v. inoculation of tumour cells. For all pretreatments except immunization, the shape of the curve of loss of radioactivity from the lungs vs time was biphasic, with an initial steep portion representing intravascular death of the tumor cells, followed 1--2 days after tumour-cell injection by a shallow exponential curve. It was concluded that the shallow slope represented spontaneous death of tumour cells in the perivascular tissues. Essentially all the injected tumour cells lodged initially in the lungs, and this was unaffected by the different host treatments. Furthermore, except for specific immunization, cell death in the perivascular tissues was also unaffected by host treatment. However, the survival of the tumour cells during the 24 h after injection (before they became extravascular) was extremely dependent on the particular host pretreatment. It would appear from these studies that host treatments such as C. parvum injection or anticoagulation can markedly affect the number of blood-borne pulmonary metastases, but they will only be effective if given before the tumor cells arrive in the lung vasculature.
DOI : 10.1038/bjc.1979.248
ISSN: 1532-1827
Cilt: 40
Sayı: 5
Sayfa: 677-688
Sınıflandırma :
Biyotıp %100
Hematoloji %36
23
Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
British Journal of Cancer
Yayıncı:
Springer Nature
Yazar(lar) :
J M Brown , D G Hirst
Konu :
Biomedicine, general, Cancer Research, Epidemiology, Molecular Medicine, Oncology, Drug Resistance
J M Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Experiments were carried out to determine whether the enhancement of alkylating-agent cytotoxicity seen after large single doses of misonidazole (MISO) in mouse tumours can also be achieved by prolonged exposure to low MISO levels similar to those which can be tolerated clinically. The level in mouse blood plasma could be maintained at about 100 micrograms/ml for 7 h by injecting small doses of MISO every 1/2 h. The effect of this treatment in combination with cyclophosphamide (CY) or melphalan (L-PAM) was studied in the RIF-1 tumour, using regrowth delay and cell-survival cloning assays. In each case, prolonged exposure to low levels of MISO gave enhancement ratios very close to those obtained with a large single dose. ERs of 1.6-2.0 were obtained with CY and 1.8-2.2 with L-PAM over the range of alkylating-agent doses used. In experiments with CY the response of 2 normal-tissue systems, marrow and WBC count, was also studied. No significant enhancement of CY damage occurred in either case. In the L-PAM experiments the LD50/30 and WBC counts were determined as normal-tissue end points. Multiple MISO had no effect. Our results show that levels of MISO which can be achieved safely in man yield good enhancement of the tumour cytotoxicity of 2 widely used chemotherapeutic agents without increasing the damage to normal tissues.
DOI : 10.1038/bjc.1982.111
ISSN: 1532-1827
Cilt: 45
Sayı: 5
Sayfa: 700-708
Sınıflandırma :
24
Effect of Dose Fractionation on the Enhancement by Radiation or Cyclophosphamide of Artificial Pulmonary Metastases
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
British Journal of Cancer
Yayıncı:
Springer Nature
Yazar(lar) :
J M Brown , G W Marsa
Konu :
Biomedicine, general, Cancer Research, Epidemiology, Molecular Medicine, Oncology, Drug Resistance
J M Brown
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Thoracic irradiation or cyclophosphamide (CP) treatment of mice before an i.v. injection of tumour cells enhances the number of lung colonies produced by a factor of up to 100+. The effect of fractionation of the X-ray or CP dose on this phenomenon was investigated in several ways. The dose-response curve for the number of lung colonies as a function of the dose of thoracic irradiation was linear, and the degree of enhancement was independent of the number of tumour cells injected. Splitting a dose of 1,000 rad into 2 equal fractions separated by times varying from 1 to 24 h gave the same enhancement as that produced by a single dose of 1000 rad. Similarly, fractionation of 1000 rad into 5 × 200 rad, or 2000 rad into 5 × 400 rad (each interval between fractions being 3 h) had no effect on the radiation enhancement of colony formation. A single dose of 200 mg/kg of CP was compared with 3 doses of 66·7 mg/kg (each dose separated by 12 h) and with a continuous infusion of 200 mg/kg given over 24 h. In this case, fractionation and infusion produced a small reduction in the CP-induced increase, but the factor of colony enhancement compared to control mice remained >100. These data emphasize the potential hazard of prophylactic treatment of pulmonary metastases by X-rays or CP in clinical situations in which control of the primary tumour is not achieved.
DOI : 10.1038/bjc.1978.148
ISSN: 1532-1827
Cilt: 37
Sayı: 6
Sayfa: 1020-1025
Sınıflandırma :
Biyotıp %78
25
Aureomycin Wastes
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Sewage and Industrial Wastes
Yayıncı:
Water Environment Federation
Yazar(lar) :
J. M. Brown
Konu :
Science and Mathematics, Aquatic Sciences
Yıl :
1952
J. M. Brown
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 24
Sayı: 4
Sayfa: pp. 488-490
Yayın Tarihi: 1952-04-01
ISSN: 0096-364X
26
Review Article
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
The Philosophical Review
Yayıncı:
Duke University Press
Yazar(lar) :
J. M. Brown
Konu :
Humanities, Philosophy
Yıl :
1957
J. M. Brown
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 66
Sayı: 4
Sayfa: pp. 570-572
Yayın Tarihi: 1957-10-01
ISSN: 0031-8108

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