Piri Keşif Aracı

Ek Bilgiler

DOI : 10.1007/s10973-013-3486-4

ISSN: 1388-6150
Sayı: 2
Cilt: 115
Sayfa: 1961-1967

2

Extended study of crystallization kinetics for Se–Te glasses

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Roman Svoboda , Ji?? M?lek

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10973-012-2347-x

ISSN: 1388-6150
Sayı: 1
Cilt: 111
Sayfa: 161-171

3

Enthalpy relaxation in Ge–Se glassy system

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Roman Svoboda , Ji?? M?lek

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10973-012-2829-x

ISSN: 1388-6150
Sayı: 2
Cilt: 113
Sayfa: 831-842

4

Crystallization kinetics of a-Se

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Roman Svoboda , Ji?? M?lek

Yıl :

2014

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10973-014-4201-9

ISSN: 1388-6150
Sayı: 2
Cilt: 119
Sayfa: 1363-1372

5

Physical modeling and simulation of inrush current in power transformers of More Electric Aircraft

Konferans Bildirileri

Kaynak :

IEEE Xplore

Yazar(lar) :

Y. Ji M. R. Kuhn

Yıl :

2013

Ji M. R. Kuhn

Ek Bilgiler

DOI : 10.1109/ifeec.2013.6687597

Doküman etkinliği ;
Etkinlik adı:2013 1st International Future Energy Electronics Conference (IFEEC)
Etkinlik yeri:Tainan, Taiwan
Etkinlik başlangıç tarihi:[2013,11,3]
Etkinlik başlangıç tarihi:[2013,11,6]

6

North Dakota Pharmacists' Need for Drug Information: 1990 VS 1980

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Drug Information Journal

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Ji M. Koo , Donald R. Miller

Yıl :

1992

Ji M. Koo

Ek Bilgiler

DOI : 10.1177/009286159202600215

ISSN: 0092-8615
Sayı: 2
Cilt: 26
Sayfa: 237-242

7

Time-related Histopathologic Changes in Fresh Frozen Carotid Xenografts in a Pig-to-Goat Implantation Model

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Artificial Organs

Yazar(lar) :

Ji M. Chang , Won G. Kim

Konu :

Medicine (miscellaneous), Bioengineering, Biomaterials, Biomedical Engineering, General Medicine

Yıl :

2009

Ji M. Chang

Ek Bilgiler

DOI : 10.1111/j.1525-1594.2009.00819.x

ISSN: 0160-564X
Sayı: 10
Cilt: 33
Sayfa: 827-834

8

Crystallization Kinetics in Amorphous and Glassy Materials

Kitap Bölümü

Kaynak :

Springer Link

Dergi:

Hot Topics in Thermal Analysis and Calorimetry

Yayıncı:

Springer Netherlands

Yazar(lar) :

Ji?? M?lek , Jana Sh?n?lov?

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/978-90-481-3150-1_14

ISSN: 1571-3105
Sayfa: 291-324

9

Moment tensor inversion for two micro-earthquakes occurring inside the H?je gas storage facilities, Czech Republic

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Seismology

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Christoforos Benetatos , Ji?? M?lek , Francesca Verga

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10950-012-9337-0

ISSN: 1383-4649
Sayı: 2
Cilt: 17
Sayfa: 557-577

10

Hepatic Arterial Infusion Combined with Systemic Chemotherapy for Patients with Extensive Liver Metastases from Gastric Cancer

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Cancer Management and Research

Yazar(lar) :

Qiang W , Shi H , Wu J , Ji M , Wu C

Yıl :

2020

Ji M

Özet Ek Bilgiler

Weiguang Qiang,1 Hongbing Shi,1 Jun Wu,1 Mei Ji,1 Changping Wu1,2 1Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of China; 2Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, People’s Republic of ChinaCorrespondence: Changping Wu; Weiguang QiangDepartment of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People’s Republic of ChinaEmail wcpjjt@163.com; qwgwutongyu@163.comPurpose: Liver metastases in patients with gastric cancer often indicate poor prognosis. Once liver metastases are extensive, it is difficult to achieve disease control by using systemic chemotherapy alone. The purpose of this study was to evaluate the effect and safety of hepatic arterial infusion (HAI) combined with systemic chemotherapy on extensive liver metastases from gastric cancer.Patients and Methods: Between 2012 and 2019, 21 patients with extensive liver metastases from gastric cancer (LMGC) were enrolled in our study. Liver metastases were identified as unresectable and a major factor affecting prognosis mainly based on size and number of intrahepatic lesions. All patients received systemic chemotherapy with S-1 and HAI oxaliplatin plus floxuridine (FUDR).Results: Liver metastases in 16 patients (76.2%) were evaluated as H3. The overall response rate was 76.2% (9.5% complete response). Intrahepatic and extrahepatic median progression-free survival times were 9.5 and 5.2 months, respectively. Median survival time (MST) was 12.3 months. All patients did not have the toxicity of grade 4. Grade 3 toxic effects included bone marrow suppression (14.3%) and diarrhea (9.5%). The other treatment-related toxicities were mild and reversible.Conclusion: HAI combined with systemic chemotherapy for extensive LMGC seems to be safe and effective, which achieves a high-local response and may contribute to long survival time for patients.Keywords: gastric cancer, liver metastases, hepatic arterial infusion, systemic chemotherapy

Anahtar Kelimeler : gastric cancer, liver metastases, hepatic arterial infusion, systemic chemotherapy

ISSN: 1179-1322
Cilt: 12
Sayfa: 2911 - 2916

Sınıflandırma :

Tıp ve Halk Sağlığı %98

Cerrahi Onkoloji %97

11

Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Hou B , Saudan P , Ott G , Wheeler ML , Ji M , Kuzmich L , Lee LM , Coffman RL , Bachmann MF , DeFranco AL

Yıl :

2011

Ji M

Özet Ek Bilgiler

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses.

Anahtar Kelimeler : b-lymphocytes, animals, signal transduction, orthomyxoviridae, antibodies, viral, germinal center, mice, knockout, mice, inbred c57bl, models, immunological, mice, dendritic cells, toll-like receptor 9, myeloid differentiation factor 88

Sınıflandırma :

Biyotıp %100

Reseptörler %78

12

Mutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Yang X , Chen R , Wu C , Zhao W , Ji M

Yıl :

2018

Ji M

Özet Ek Bilgiler

Xin Yang, Rui Chen, Chen Wu, Weiqing Zhao, Mei Ji Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China Abstract: Rapid metastasis contributes significantly to the high mortality rates in lung adenocarcinoma. The present study reports a rare case of primary lung adenocarcinoma with concomitant gastric, duodenal, bone, and mediastinal lymph node metastases. A large gene panel based on the next-generation sequencing was used to detect gene mutations in different metastatic sites and blood. The results showed that the gene mutation spectrums among different metastatic foci were roughly similar. The mutation abundance was highest in mediastinal lymph nodes. Unique mutation sites were detected only in mediastinal lymph nodes, bone, and gastric metastatic foci. Despite partial heterogeneity, there are currently no applicable targeted drugs to adopt. In addition, tumor mutation burden (TMB) showed that blood, gastric, bone, and mediastinal lymph node metastases were all TMB-High, while the duodenal metastasis was TMB-Low. This study is the first to report a rare case of newly diagnosed lung adenocarcinoma with concomitant gastrointestinal metastases and to perform mutation analyses on all metastatic foci. Large sample sizes with similar cases are required to gain deeper insights. Keywords: lung adenocarcinoma, gastric metastasis, duodenal metastasis, TMB

Anahtar Kelimeler : lung adenocarcinoma, gastric metastasis, duodenal metastasis

ISSN: 1178-6930
Cilt: 11
Sayfa: 4029 - 4034

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Cerrahi Onkoloji %98

13

Semi-blind Source Separation Based on ICA and Overlapped Speech Detection

Kitap Bölümü

Kaynak :

Springer Link

Dergi:

Latent Variable Analysis and Signal Separation

Yayıncı:

Springer Berlin Heidelberg

Yazar(lar) :

Ji?? M?lek , Zbyn?k Koldovsk? , Petr Tichavsk?

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/978-3-642-28551-6_57

ISSN: 0302-9743
Sayfa: 462-469

14

P3-237: Expression characteristics and prognostic significances of MUC1 and MUC4 in non-small cell lung carcinoma

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of Thoracic Oncology

Yayıncı:

Elsevier

Yazar(lar) :

Kun Y. Kwon , Ji M. Jeon , Won I. Choi

Yıl :

2007

Ji M. Jeon

Ek Bilgiler

DOI : 10.1097/01.jto.0000284212.37096.ad

ISSN: 1556-0864
Sayı: 8
Cilt: 2
Sayfa: S781

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Onkoloji %100

15

RT-LAMP for rapid diagnosis of coronavirus SARS-CoV-2

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Huang WE , Boon L , Hsu C-C , Xiong D , Wu W , Yu Y , Jia H , Zeng Y , Ji M , Chang H , Zhang X , Wang H , Cui Z

Yıl :

2020

Ji M

Özet Ek Bilgiler

The pandemic coronavirus SARS‐CoV‐2 in the world has caused a large infected population suffering from COVID‐19. To curb the spreading of the virus, WHO urgently demanded an extension of screening and testing; thus, a rapid and simple diagnostic method is needed. We applied a reverse transcription‐loop‐mediated isothermal amplification (RT‐LAMP) to achieve the detection of SARS‐CoV‐2 in 30 min. We designed four sets of LAMP primers (6 primers in each set), targeting the viral RNA of SARS‐CoV‐2 in the regions of orf1ab, S gene and N gene. A colorimetric change was used to report the results, which enables the outcome of viral RNA amplification to be read by the naked eye without the need of expensive or dedicated instrument. The sensitivity can be 80 copies of viral RNA per ml in a sample. We validated the RT‐LAMP method in a hospital in China, employing 16 clinic samples with 8 positives and 8 negatives. The testing results are consistent with the conventional RT‐qPCR. In addition, we also show that one‐step process without RNA extraction is feasible to achieve RNA amplification directly from a sample. This rapid, simple and sensitive RT‐LAMP method paves a way for a large screening at public domain and hospitals, particularly regional hospitals and medical centres in rural areas.

Anahtar Kelimeler : loop-mediated isothermal amplification (lamp), colorimetric, one step reaction, reverse transcription, sars-cov-2 virus, diagnosis, covid-19

Sınıflandırma :

Biyotıp %91

Viroloji %100

16

LXY6090 – a novel manassantin A derivative – limits breast cancer growth through hypoxia-inducible factor-1 inhibition

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Lai F , Liu Q , Liu X , Ji M , Xie P , Chen X

Yıl :

2016

Ji M

Özet Ek Bilgiler

Fangfang Lai,1 Qian Liu,2 Xiaoyu Liu,3 Ming Ji,1 Ping Xie,3 Xiaoguang Chen1 1Department of Pharmacology, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2Department of Pharmacology, National Institutes for Food and Drug Control, 3Department of Pharmacochemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Abstract: Hypoxia-inducible factor-1 (HIF-1) represents a novel antitumor target owing to its involvement in vital processes considered hallmarks of cancer phenotypes. Manassantin A (MA) derived from Saururus cernuus has been reported as a selective HIF-1 inhibitor. Herein, the structure of MA was optimized to achieve new derivatives with simple chemical properties while retaining its activity. LXY6090 was designed to replace the central tetrahydrofuran moiety of MA with a cyclopentane ring and was identified as a potent HIF-1 inhibitor with an IC50 value of 4.11 nM. It not only inhibited the activity of HIF-1 in breast cancer cells but also downregulated the protein level of HIF-1α, which depended on von Hippel–Lindau for proteasome degradation. The related biological evaluation showed that the activity of HIF-1 target genes, VEGF and IGF-2, was decreased by LXY6090 in breast cancer cell lines. LXY6090 presented potent antitumor activity in vitro. Furthermore, LXY6090 showed in vivo anticancer efficacy by decreasing the HIF-1α expression in nude mice bearing MX-1 tumor xenografts. In conclusion, our data provide a basis for the future development of the novel compound LXY6090 as a potential therapeutic agent for breast cancer. Keywords: hypoxia-inducible factor-1, manassantin A derivative, antitumor, breast cancer, LXY6090

Anahtar Kelimeler : Hypoxia-inducible factor 1 (HIF-1), Manassantin A derivative, anti-tumor, breast cancer, LXY6090

ISSN: 1178-6930
Cilt: 2016
Sayı: 1
Sayfa: 3829 - 3840

Sınıflandırma :

Biyotıp %98

Farmakoloji ve Toksikoloji %79

17

Development of a rapid test kit for SARS-CoV-2: an example of product design

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Cui Z , Chang H , Wang H , Lim B , Hsu C-C , Yu Y , Jia H , Wang Y , Zeng Y , Ji M , Liu W , Inverarity C , Huang WE

Yıl :

2020

Ji M

Özet Ek Bilgiler

We present an example of applying ‘need-driven’ product design principle to the development of a rapid test kit to detect SARS-COV-2 (COVID-19). The tests are intended for use in the field and, longer term, for home use. They detect whether a subject is currently infected with the virus and is infectious. The urgent need for large numbers of tests in field setting imposes constraints such as short test time and lack of access to specialist equipment, laboratories and skilled technicians to perform the test and interpret results. To meet these needs, an antigen test based on RT-LAMP with colorimetric readout was chosen. Direct use of swab sample with no RNA extraction was explored. After extensive experimental study (reported elsewhere), a rapid test kit has been fabricated to satisfy all design criteria.

Anahtar Kelimeler : covid-19, sar-cov-2, rt-lamp, rapid test, antigen detection, product design

Sınıflandırma :

Mühendislik %93

Otomotiv Mühendisliği %41

18

Endometrial carcinoma with yolk sac tumor-like differentiation and elevated serum ß-hCG: a case report and literature review

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Ji M , Lu Y , Guo L , Feng F , Wan X , Xiang Y

Yıl :

2013

Ji M

Özet Ek Bilgiler

Mingliang Ji,1 Yan Lu,1 Lina Guo,2 Fengzhi Feng,1 Xirun Wan,1 Yang Xiang1 1Department of Obstetrics and Gynecology, 2Department of Pathology, Peking Union Medical College Hospital, Beijing, People's Republic of China Abstract: Endometrial carcinoma with a germ cell tumor component is a rare event. Here we report a uterine neoplasm with a unique combination of endometrioid adenocarcinoma and mixed germ cell malignant elements. A 28-year-old woman with abnormal vaginal bleeding, an abdominal mass, and elevated alfa-fetoprotein and beta-human chorionic gonadotropin (ß-hCG) levels had a history of biopsy of an omental mass and chemotherapy in another hospital one month before her referral to our department. Histologic examination of the mass removed from the omentum revealed an endometrioid adenocarcinoma with yolk sac tumor-like differentiation. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy, and removal of metastatic disease were then undertaken at our hospital. Postoperative chemotherapy was given. Eight months postoperatively, serum alfa-fetoprotein and ß-hCG rose again. Cases with primary yolk sac tumors of the endometrium or endometrial carcinoma with trophoblastic differentiation in the literature were reviewed. Keywords: endometrial carcinoma, yolk sac tumor, trophoblastic differentiation

ISSN: 1178-6930
Cilt: 2013
Sayı: default
Sayfa: 1515 - 1522

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Jinekoloji %99

19

The Role of Methyltransferase NSD2 as a Potential Oncogene in Human Solid Tumors

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Chen R , Chen Y , Zhao W , Fang C , Zhou W , Yang X , Ji M

Yıl :

2020

Ji M

Özet Ek Bilgiler

Rui Chen, Yan Chen, Weiqing Zhao, Cheng Fang, Wenjie Zhou, Xin Yang, Mei Ji Department of Oncology, The Third Affiliated Hospital of Soochow University, The First People’s Hospital of Changzhou, Changzhou 213003, People’s Republic of ChinaCorrespondence: Xin Yang; Mei Ji Email yangxindoctor@163.com; zlkjimei@163.comAbstract: Malignant solid tumors are the leading cause of death in humans, and epigenetic regulation plays a significant role in studying the mechanism of human solid tumors. Recently, histone lysine methylation has been demonstrated to be involved in the development of human solid tumors due to its epigenetic stability and some other advantages. The 90-kb protein methyltransferase nuclear receptor SET domain-containing 2 (NSD2) is a member of nuclear receptor SET domain-containing (NSD) protein lysine methyltransferase (KMT) family, which can cause epigenomic aberrations via altering the methylation states. Studies have shown that NSD2 is frequently over-expressed in multiple types of aggressive solid tumors, including breast cancer, renal cancer, prostate cancer, cervical cancer, and osteosarcoma, and such up-regulation has been linked to poor prognosis and recurrence. Further studies have identified that over-expression of NSD2 promotes cell proliferation, migration, invasion, and epithelial–mesenchymal transformation (EMT), suggesting its potential oncogenic role in solid tumors. Moreover, Gene Expression Profiling Interactive Analysis (GEPIA) was searched for validation of prognostic value of NSD2 in human solid tumors. However, the underlying specific mechanism remains unclear. In our present work, we summarized the latest advances in NSD2 expression and clinical applications in solid tumors, and our findings provided valuable insights into the targeted therapeutic regimens of solid tumors.Keywords: NSD2, proliferation, migration, invasion, EMT, oncogene

Anahtar Kelimeler : proliferation, migration, invasion, oncogene

ISSN: 1178-6930
Cilt: 13
Sayfa: 6837 - 6846

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %75

20

The Effects of Type 2 Diabetes and Postoperative Pneumonia on the Mortality in Inpatients with Surgery

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy

Yazar(lar) :

Ma C , Liu Q , Li M , Ji M , Zhang J , Zhang B , Yin FZ

Yıl :

2019

Ji M

Özet Ek Bilgiler

Chun-ming Ma, Qin Liu, Ming-li Li, Mei-jing Ji, Jian-dong Zhang, Bo-hua Zhang, Fu-Zai Yin Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, People’s Republic of ChinaCorrespondence: Fu-Zai YinDepartment of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, People’s Republic of ChinaTel +86-335-5908368Fax +86-335-3032042Email yinfuzai62@163.comObjective: The aim of the study was to explore the relationship between type 2 diabetes (T2DM) and postoperative pneumonia, and the effects of T2DM and postoperative pneumonia on the mortality in inpatients with surgery.Methods: A retrospective study was conducted on 43,174 inpatients with surgery in The First Hospital of Qinhuangdao. These patients were divided into four groups according to T2DM and postoperative pneumonia, Group A subjects without T2DM and postoperative pneumonia, Group B subjects with T2DM only, Group C subjects with postoperative pneumonia only and Group D subjects with T2DM and postoperative pneumonia. In-hospital mortality was collected.Results: The incidences of postoperative pneumonia were higher in patients with T2DM than patients without T2DM (T2DM 3.2% vs Non-diabetes 1.7%, χ2=36.219, P<0.001). The mortalities were 0.3% in Group A, 0.3% in Group B, 4.6% in Group C and 8.6% in Group D. In multiple logistic regression analysis, adjusted for sex, age, emergency admissions, coronary heart disease, heart failure, chronic kidney disease, hypoproteinemia, stroke and transient ischemic attack, the mortalities of Group C and Group D were 4.515 (95% CI: 2.779～7.336, P<0.001) times and 8.468 (95% CI: 3.567～20.099, P<0.001) times than the mortality of Group A.Conclusion: T2DM is susceptible to postoperative pneumonia. The mortality increased in patients with postoperative pneumonia. When patients with T2DM and postoperative pneumonia at the same time, the mortality increased further. In T2DM patients with postoperative pneumonia, perioperative management should be improved for patient safety.Keywords: type 2 diabetes, postoperative pneumonia, mortality

Anahtar Kelimeler : type 2 diabetes；postoperative pneumonia；mortality.

ISSN: 1178-7007
Cilt: 12
Sayfa: 2507 - 2513

21

TMEM119 promotes gastric cancer cell migration and invasion through STAT3 signaling pathway

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Zheng P , Wang W , Ji M , Zhu Q , Feng Y , Zhou F , He Q

Yıl :

2018

Ji M

Özet Ek Bilgiler

Peifen Zheng, Weifeng Wang, Muxi Ji, Qin Zhu, Yuliang Feng, Feng Zhou, Qiaona He Department of Gastroenterology, Zhejiang Hospital, Hangzhou, People’s Republic of China Objective: TMEM119 is a member of transmembrane proteins family, which is abnormally expressed in human cancers and associated with tumorigenesis. In this study, we focused on the expression of TMEM119 and its role in cell invasion and migration in gastric cancer. Methods: Real-time polymerase chain reaction, Western blotting, and immunohistochemistry were performed to examine the expression of TMEM119 in gastric cancer tissues and cell lines. After transfection with TMEM119 siRNA or recombined TMEM119-expressing vector, the invasion and migration ability of MKN45 and SGC-7901 cells was measured by transwell assay. The expression of TMEM119, p-STAT3, STAT3, VEGF, MMP2, and MMP9 proteins in SGC-7901 and MKN45 cells treated with TMEM119 siRNA, TMEM119-expressing vector, or AG490 was measured by Western blotting. Results: We found that higher TMEM119 expression was found in gastric cancer tissues and cell lines and was associated with lower survival rate. TMEM119 knockdown inhibited SGC-7901 cell invasion and migration, along with the expression of p-STAT3, VEGF, MMP2, and MMP9. TMEM119 overexpression promoted MKN45 cell invasion and migration, along with the expression of p-STAT3, VEGF, MMP2, and MMP9. Additionally, AG490 treatment significantly corrected TMEM119-induced MKN45 cell migration and invasion and expression of p-STAT3, VEGF, MMP9, and MMP2 proteins. Conclusion: The results indicated that TMEM119 promotes gastric cancer cell migration and invasion through activation of STAT3 signaling pathway, and TMEM119 may therefore act as a novel therapeutic target for gastric cancer. Keywords: gastric cancer, TMEM119, migration, invasion, STAT3, VEGF, MMP2, MMP9

Anahtar Kelimeler : gastric cancer, TMEM119, migration, invasion, STAT3

ISSN: 1178-6930
Cilt: 11
Sayfa: 5835 - 5844

Sınıflandırma :

Biyotıp %100

Hücre Biyolojisi %94

22

Mupirocin resistance among MRSA surveillance isolates from neonatal intensive care unit under 10 year-search and destroy policy compared to

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

BMC Proceedings

Yazar(lar) :

Kim M-N , Kim H , An D , Ji M , Lee M , Kim A-R , Lee SJ

Yıl :

2011

Ji M

Piri Tam Metin Bulucu Ek Bilgiler

DOI : 10.1186/1753-6561-5-S6-P171

ISSN: 1753-6561
Cilt: 5
Sayı: Suppl 6
Sayfa: P171

Sınıflandırma :

Yaşam Bilimleri %95

Tıbbi Mikrobiyoloji %58

23

The effect of crystal structure on the thermal reactivity of CL-20 and its C4-bonded explosives

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Qi-Long Yan , Svatopluk Zeman , Roman Svoboda , Ahmed Elbeih , Ji?? M?lek

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10973-012-2629-3

ISSN: 1388-6150
Sayı: 2
Cilt: 112
Sayfa: 837-849

24

PTU-056 Loss of cathelicidin (LL-37) is associated with colorectal cancer progression

Konferans Bildirileri

Kaynak :

The BMJ

Dergi:

Colon and Anorectum

Yazar(lar) :

Ross J Porter , Graeme I Murray , Ji M Wang , Teizo Yoshimura , Mairi H McLean

Yıl :

2018

Ji M Wang

Ek Bilgiler

DOI : 10.1136/gutjnl-2018-bsgabstracts.397

Doküman etkinliği ;
Etkinlik adı:British Society of Gastroenterology, Annual General Meeting, 4–7 June 2018, Abstracts

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Veterinerlik ve Veterinerlik Bilimi %100

25

The effect of crystal structure on the thermal reactivity of CL-20 and its C4 bonded explosives (I): thermodynamic properties and decomposition kinetics

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Qi-Long Yan , Svatopluk Zeman , Ahmed Elbeih , Zhen-Wei Song , Ji?? M?lek

Yıl :

2012

Ji?? M?lek

Ek Bilgiler

DOI : 10.1007/s10973-012-2711-x

ISSN: 1388-6150
Sayı: 2
Cilt: 112
Sayfa: 823-836

26

Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Tang W , Ji M , He G , Yang L , Niu Z , Jian M , Wei Y , Ren L , Xu J

Yıl :

2017

Ji M

Özet Ek Bilgiler

Wentao Tang,* Meiling Ji,* Guodong He,* Liangliang Yang, Zhengchuan Niu, Mi Jian, Ye Wei, Li Ren, Jianmin Xu Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: An increasing number of studies have demonstrated that circular RNAs (circRNAs) can regulate gene expression through interacting with microRNAs. In this study, we analyzed the expression of antisense to CDR1as in colorectal cancer (CRC). CDR1as had a higher expression in CRC tissues compared to adjacent, normal mucosa and was positively associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS). Downregulation of CDR1as suppressed CRC cell proliferation and invasion and increased microRNA-7 (miR-7) expression. Intriguingly, ectopic expression of miR-7 in CRC cells consistently inhibited proliferation and invasion, and the miR-7 inhibitor was able to rescue the function of CDR1as knockdown. Mechanistic studies demonstrated that CDR1as silencing suppressed EGFR and IGF-1R expression, which could be partially blocked by the miR-7 inhibitor. Finally, positive correlations between CDR1as expression and EGFR and IGF-1R expression were observed in CRC samples. Thus, given the importance of CDR1as in blocking miR-7 and positively regulating EGFR and IGF-1R, dysregulated CDR1as expression may play an important role in CRC progression. Keywords: CDR1as, colorectal cancer, microRNA-7, proliferation

Anahtar Kelimeler : CDR1as, Colorectal cancer, microRNA-7, proliferation

ISSN: 1178-6930
Cilt: 10
Sayfa: 2045 - 2056

Sınıflandırma :

Biyotıp %100

Hücre Biyolojisi %77

27

Long-Term Survival After Nasopharyngeal Carcinoma Treatment in a Local Prefecture-Level Hospital in Southern China

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Cancer Management and Research

Yazar(lar) :

Du Y , Zhang W , Lei F , Yu X , Li Z , Liu X , Ni Y , Deng L , Ji M

Yıl :

2020

Ji M

Özet Ek Bilgiler

Yun Du,1,2 Wentong Zhang,3 Feng Lei,4 Xia Yu,1 Zhuming Li,1 Xiaodong Liu,1 Yanan Ni,1 Li Deng,4 Mingfang Ji1 1Cancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital, Zhongshan 528400, People’s Republic of China; 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Stockholm, Sweden; 3Department of Chinese Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 4Department of Radiotherapy, Zhongshan City People’s Hospital, Zhongshan, People’s Republic of ChinaCorrespondence: Mingfang JiCancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital, No. 2. Sunwen Road East, Zhongshan 528400, Guangdong, People’s Republic of ChinaTel +86 135 3206 2222Fax +86 076488822698Email jmftbh@sina.comPurpose: NPC is a malignant and invasive tumor with the incidence rate of 19/100,000 per year in Zhongshan City, a prefecture city in southern China. Long-term survival analysis on intensity-modulated radiotherapy (IMRT)-based treatment in local prefecture-level hospitals have not been investigated. We aimed to evaluate the 5-year clinical outcomes and prognostic factors of NPC treated with IMRT in Zhongshan City People’s Hospital (ZSPH), a prefecture-level hospital in South China.Patients and Methods: The number of 149 newly diagnosed non-metastatic NPC cases treated with IMRT were included from Zhongshan City People’s Hospital between January 2010 and December 2011. The survival outcomes, treatment toxicities and prognostic factors were analyzed by Kaplan-Meier method and Cox proportional hazards model.Results: With a median follow-up period of 65 months for the cohort, the 5-year local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS) and distant metastasis-free survival (DMFS) and overall survival (OS) were 86.80%, 94.80%, 86.10% and 80.50%, respectively. The 5-year OS rates were 100%, 95.2%, 87% and 67.2% for stage I, II, II and IVa-b, respectively (P=0.004). The 5-year LRFS rates were 97.2%, 96.0%, 90.4% and 72.0% for T1, T2, T3 and T4, respectively (P=0.001); the 5-year DMFS rates were 100% for T1, 96.8% for T2, 81.9% for T3 and 74.6% for T4 (P=0.022). A multivariate analysis revealed tumor stage as an independent prognostic factor for LRFS, DMFS and OS. No patients died from acute toxicities. Late toxicities were observed for 130 (87.2%) patients, and most late toxicities were graded I/II.Conclusion: NPC treatment effect in a prefecture-level hospital in South China was comparable to international results and toxicities were tolerable. Tumour stage was an independent prognostic factor for survival outcome. More NPC survival data from local and remote places are needed.Keywords: nasopharyngeal carcinoma, intensity-modulated, radiotherapy, prognosis, long-term survival results

Anahtar Kelimeler : nasopharyngeal carcinoma, intensity-modulated, radiotherapy, prognosis, long-term survival results.

ISSN: 1179-1322
Cilt: 12
Sayfa: 1329 - 1338

Sınıflandırma :

Biyotıp %62

Epidemiyoloji %59

Tropik ilaç %39

Tıp ve Halk Sağlığı %31

Kültürel çalışmalar %100

28

Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Nanomedicine

Yazar(lar) :

Xing J , Zhang X , Wang Z , Zhang H , Chen P , Zhou G , Sun C , Gu N , Ji M

Yıl :

2019

Ji M

Özet Ek Bilgiler

Jing Xing,*,1,2 Xiquan Zhang,*,3 Zhe Wang,4 Huanqing Zhang,3 Peng Chen,1,2 Gaoxin Zhou,5 Chunlong Sun,6 Ning Gu,1,2 Min Ji1,21School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, People’s Republic of China; 2School of Biological Science and Medical Engineering and Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Suzhou 215123, People’s Republic of China; 3Nanjing Institute of Pharmaceutical Research and Development, Chia-Tai Tianqing Pharmaceutical Group Co. Ltd, Nanjing 210023, People’s Republic of China; 4Emergency Department, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 5School of Biomedical Engineering, Shenzhen University, Shenzhen 518071, People’s Republic of China; 6College of Biological and Environmental Engineering, Binzhou University, Binzhou 256603, People’s Republic of China*These authors contributed equally to this workBackground: SN38 (7-ethyl-10-hydroxy camptothecin), as a potent metabolite of irinotecan, is highly efficacious in cancer treatment. However, the clinical utility of SN38 has been greatly limited due to its undesirable properties, such as poor solubility and low stability.Materials and methods: In order to overcome these weaknesses, moeixitecan, a lipophilic SN38 prodrug containing a SN-38, a trolox, a succinic acid linker, and a hexadecanol chain, was loaded into liposomal nanoparticles by ethanol injection method.Results: Experiments showed that the moeixitecan-loaded liposomal nanoparticles (MLP) with a diameter of 105.10±1.49 nm have a satisfactory drug loading rate (90.54±0.41%), high solubility and stability, and showed sustained release of SN38. Notably, MLP exhibited better antitumor activity against human colon adenocarcinoma cells than irinotecan, a FDA-approved drug for the treatment of advanced colorectal cancer. Furthermore, xenograft model results showed that MLP outperformed irinotecan in terms of pharmacokinetics, in vivo therapeutic efficacy and safety. Finally, we used molecular dynamic simulations to explore the association between the structure of MLP and the physical and functional properties of MLP, moeixitecan molecules in MLP folded themselves inside the hydrocarbon chain of the lipid bilayer, which led an increased acyl chain order of the lipid bilayer, and therefore enhanced the lactone ring stability protecting it from hydrolysis.Conclusion: Our MLP constructing strategy by liposome engineering technology may serve a promising universal approach for the effective and safe delivery of lipophilic prodrug.Keywords: SN38, lipophilic prodrug, liposomes, molecular dynamic simulations, cancer therapy

Anahtar Kelimeler : lipophilic prodrug, liposomes, Molecular dynamic simulations, Cancer therapy

Cilt: 14
Sayfa: 5201 - 5213

Sınıflandırma :

Biyotıp %96

Farmakoloji ve Toksikoloji %73

29

Influence of temperature on early hydration of Portland cement–metakaolin–slag system

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Journal of Thermal Analysis and Calorimetry

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Martin Boh?? , Martin Palou , Radoslav Novotn? , Ji?? M?silko , Franti?ek ?oukal , Tom?? Opravil

Yıl :

2016

Ji?? M?silko

Ek Bilgiler

DOI : 10.1007/s10973-016-5592-6

ISSN: 1388-6150
Sayı: 1
Cilt: 127
Sayfa: 309-318

30

CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro9,10-b-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O6-methylguanine DNA methyltransferase expression

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Ji M , Wang L , Chen J , Xue N , Wang C , Lai F , Wang R , Yu SS , Jin J , Chen X

Yıl :

2018

Ji M

Özet Ek Bilgiler