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Mesenchymal potentials of the trunk neural crest cells
Tez

Tez
Open Access
Kaynak :
The Dart-Europe
Dergi:
Université Paris Sud - Paris XI
Yazar(lar) :
Juliana De Mattos Coelho Aguiar
Yıl :
2012
Juliana De Mattos Coelho Aguiar
Yayıncı Web Sitesi
Kaydet Alıntıla
Sınıflandırma :
2
Laminin and Environmental Cues Act in the Inhibition of the Neuronal Differentiation of Enteric Glia in vitro
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Neuroscience
Yazar(lar) :
Carla Pires Veríssimo , Carla Pires Veríssimo , Carla Pires Veríssimo , Juliana da Silva Carvalho , Fábio Jorge Moreira da Silva , Loraine Campanati , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Juliana de Mattos Coelho-Aguiar , Juliana de Mattos Coelho-Aguiar
Yıl :
2019
Juliana de Mattos Coelho-Aguiar Juliana de Mattos Coelho-Aguiar
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Kaydet Alıntıla
The enteric glia, a neural crest-derived cell type that composes the Enteric Nervous System, is involved in controlling gut functions, including motility, gut permeability, and neuronal communication. Moreover this glial cell could to give rise to new neurons. It is believed that enteric neurons are generated up to 21 days postnatally; however, adult gut cells with glial characteristics can give rise to new enteric neurons under certain conditions. The factors that activate this capability of enteric glia to differentiate into neurons remain unknown. Here, we followed the progress of this neuronal differentiation and investigated this ability by challenging enteric glial cells with different culture conditions. We found that, in vitro, enteric glial cells from the gut of adult and neonate mice have a high capability to acquire neuronal markers and undergoing morphological changes. In a co-culture system with 3T3 fibroblasts, the number of glial cells expressing βIIItubulin decreased after 7 days. The effect of 3T3-conditioned medium on adult cells was not significant, and fewer enteric glial cells from neonate mice began the neurogenic process in this medium. Laminin, an extracellular matrix protein that is highly expressed by the niche of the enteric ganglia, seemed to have a large role in inhibiting the differentiation of enteric glia, at least in cells from the adult gut. Our results suggest that, in an in vitro approach that provides conditions more similar to those of enteric glial cells in vivo, these cells could, to some extent, retain their morphology and marker expression, with their neurogenic potential inhibited. Importantly, laminin seemed to inhibit differentiation of adult enteric glial cells. It is possible that the differentiation of enteric glia into neurons is related to severe changes in the microenvironment, leading to disruption of the basement membrane. In summary, our data indicated that the interaction between the enteric glial cells and their microenvironment molecules significantly affects the control of their behavior and functions.
DOI : 10.3389/fnins.2019.00914
Anahtar Kelimeler : enteric glia, neurogenesis, laminin, cell culture, microenvironment
Cilt: 13
Sınıflandırma :
3
The role of Aquaporins in Hearing Function and Dysfunction
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
European Journal of Cell Biology
Yayıncı:
Elsevier BV
Yazar(lar) :
Adriana Ximenes-da-Silva , Daniela Capra , Carolina Kaminski Sanz , Carmelita Bastos Mendes , Juliana de Mattos Coelho Aguiar , Vivaldo Moura-Neto , Marcos F. DosSantos
Yıl :
2022
Juliana de Mattos Coelho Aguiar
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Kaydet Alıntıla
The inner ear is composed by tiny and complex structures that, together with peripheral and central auditory pathways, are responsible for hearing processing. However, not only the anatomy of the cochlea, its compartments and related structures are complex. The mechanisms involved in the regulation of homeostasis in the inner ear fluid, which determines the ionic gradient necessary for hearing and balancing sensory excitability, is an intricate phenomenon that involves several molecules. Among them, Aquaporins (AQP) play a significant role in this process. AQP are part of a family of small, integral membrane proteins that regulate different processes, including bidirectional water and ionic flow in the inner ear. Changes in the expression of these proteins are essential to auditory physiology and several pathophysiological processes in the inner ear. This review focuses on the role of AQP in health and disease of the auditory system.
DOI : 10.1016/j.ejcb.2022.151252
Anahtar Kelimeler : aquaporins, hearing impairment, cochlea, spiral ganglion, stria vascularis
ISSN: 0171-9335
Sayfa: 151252
Sınıflandırma :
4
The Enteric Glia: Identity and Functions
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Yazar(lar) :
Juliana de Mattos Coelho-Aguiar , Ana Carina Bon-Frauches , Ana Lúcia Tavares Gomes , Carla Pires Veríssimo , Diego Pinheiro Aguiar , Diana Matias , Beatriz Bastos de Moraes Thomasi , Antoniella Souza Gomes , Gerly Anne de Castro Brito , Vivaldo Moura-Neto
Yıl :
2015
Juliana de Mattos Coelho-Aguiar
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Kaydet Alıntıla
Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central nervous system (CNS), such as in their expression of the same markers and in their functions. Here we review the construction of the enteric nervous system (ENS), with a focus on enteric glia, and also the main studies that have revealed the action of enteric glia in different aspects of gastrointestinal tract homeostasis, such as in the intestinal barrier, in communications with neurons, and in their action as progenitor cells. We also discuss recent discoveries about the roles of enteric glia in different disorders that affect the ENS, such as degenerative pathologies including Parkinson's and prion diseases, and in cases of intestinal diseases and injury. GLIA 2015;63:921–935
DOI : 10.1002/glia.22795
ISSN: 0894-1491
Sayı: 6
Cilt: 63
Sayfa: 921-935
Sınıflandırma :
5
Enteric glial cell reactivity in colonic layers and mucosal modulation in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Brain Research Bulletin
Yayıncı:
Elsevier BV
Yazar(lar) :
Beatriz Bastos de Moraes Thomasi , Luisa Valdetaro , Maria Carolina Garcia Ricciardi , Lívia Hayashide , Ana Carolina Moraes Neves Fernandes , Amanda Mussauer , Mayara Lídia da Silva , Adriana da Cunha Faria-Melibeu , Manuel Gustavo Leitão Ribeiro , Juliana de Mattos Coelho-Aguiar , Paula Campello-Costa , Vivaldo Moura-Neto , Ana Lúcia Tavares-Gomes
Yıl :
2022
Juliana de Mattos Coelho-Aguiar
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Kaydet Alıntıla
Enteric glial cells (EGCs) constitute the majority of the neural population of the enteric nervous system and are found in all layers of the gastrointestinal tract. It is active in enteric functions such as immunomodulation, participating in inflammation and intestinal epithelial barrier (IEB) regulation. Both EGCs and IEB have been described as altered in Parkinson's disease (PD). Using an animal model of PD induced by 6-hydroxydopamine (6-OHDA), we investigated the effect of ongoing neurodegeneration on EGCs and inflammatory response during short periods after model induction. C57Bl/6 male mice were unilaterally injected with 6-OHDA in the striatum. Compared to the control group, 6-OHDA animals showed decreased relative water content in their feces from 1 w after model induction. Moreover, at 1 and 2 w post-induction, groups showed histopathological changes indicative of intestinal inflammation. We identified an increase in IBA1 and GFAP levels in the intestinal mucosa. At an earlier survival of 48 h, we detected an increase in GFAP in the neuromuscular layer, suggesting that it was a primary event for the upregulation of GDNF, TNF-α, and occludin in the intestinal mucosa observed after 1 w. Within 2 w, we identified a decrease in the expression of occludin barrier proteins. Thus, EGC modulation may be an early enteric signal induced by parkinsonian neurodegeneration, followed by inflammatory and dysmotility signs besides IEB modification.
DOI : 10.1016/j.brainresbull.2022.06.013
Anahtar Kelimeler : CTTF corrected total tissue fluorescence, corrected total tissue fluorescence, EGC enteric glial cells, enteric glial cells, ENS enteric nervous system, enteric nervous system, GDNF glial cell line-derived neurotrophic factor, glial cell line-derived neurotrophic factor, GFAP glial fibrillary acidic protein, glial fibrillary acidic protein, GIT gastrointestinal tract, gastrointestinal tract, IBA1 ionized calcium binding adaptor molecule 1, ionized calcium binding adaptor molecule 1, IEB intestinal epithelial barrier, intestinal epithelial barrier, H&E Hematoxylin and eosin, Hematoxylin and eosin, PD Parkinson's disease, Parkinson's disease, TH tyrosine hydroxylase, tyrosine hydroxylase, TNF-α tumor necrosis factor α, tumor necrosis factor α, 6-OHDA 6-hydroxydopamine, 6-hydroxydopamine, enteric glia, Parkinsonu2019s disease model, inflammation, intestinal epithelial barrier, gut-brain axis
ISSN: 0361-9230
6
The Enteric Glial Network Acts in the Maintenance of Intestinal Homeostasis and in Intestinal Disorders
e-Kitap

e-Kitap
Open Access
Kaynak :
IntechOpen
Yazar(lar) :
Juliana de Mattos Coelho-Aguiar , Carla Pires Veríssimo , Deiziane Viana da Silva Costa , Beatriz Bastos de Moraes Thomasi , Ana Carina Bon Frauches , Fabiana Pereira Ribeiro , Ana Lucia Tavares Gomes , Gerly Anne de Castro Brito , Vivaldo Moura-Neto
Yıl :
2019
Juliana de Mattos Coelho-Aguiar
Yayıncı Web Sitesi
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Kaydet Alıntıla
The enteric nervous system (ENS), also known as second brain, innervates our gastrointestinal tract controlling its functions, such as motility, fluid secretion, nutrient absorption, and even involvement in the control of immunity and inflammatory processes. In the gut, the gliocytes are known as enteric glial cells (EGCs). Enteric glial cells form a network that permeates the entire gut. Enteric glia express the cell surface hemichannel of connexin-43 (Cx43) necessary for the propagation of Ca2 + responses, necessary to maintain their functions. In this chapter, besides the development of ENS and its glial cells and the similarities with the astrocytes in the central nervous system, we approached the important role of the glial network in the control of gut homeostasis, in the interaction with the immune system, and its participation in pathological conditions. EGCs are even capable of replacing lost neurons. Thus the enteric glia is a multifunctional cell, which through its multiple interactions maintains the integrity of the ENS allowing it to be resistant to the different and constant aggressions suffered by the digestive system.
DOI : 10.5772/intechopen.89170
Anahtar Kelimeler : enteric neurodegeneration, gut inflammation, gut homeostasis, glial network, enteric glial cells
Sınıflandırma :
Biyotıp %100
Nörokimya %59
7
Neuromechanisms of SARS-CoV-2: A Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Neuroanatomy
Yazar(lar) :
Marcos F. DosSantos , Marcos F. DosSantos , Marcos F. DosSantos , Sylvie Devalle , Veronica Aran , Daniela Capra , Daniela Capra , Daniela Capra , Natália Roberta Roque , Juliana de Mattos Coelho-Aguiar , Tânia Cristina Leite de Sampaio e Spohr , Tânia Cristina Leite de Sampaio e Spohr , Janice Gonçalves Subilhaga , Cláudia Maria Pereira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Paulo Niemeyer Soares Filho , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto
Yıl :
2020
Juliana de Mattos Coelho-Aguiar
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Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.
DOI : 10.3389/fnana.2020.00037
Anahtar Kelimeler : SARS-CoV-2, COVID-19, central nervous system, peripheral nervous system, anosmia, dysgeusia
ISSN: 1662-5129
Cilt: 14
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