• Piri Keşif Aracı

Arama ipuçları nelerdir?
1.  sayfa ve
1
Erlotinib loaded chitosan nanoparticles: Formulation, physicochemical characterization and cytotoxic potential
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
International Journal of Biological Macromolecules
Yayıncı:
Elsevier
Yazar(lar) :
Parijat Pandey , Kamal Dua , Harish Dureja
Yıl :
2019
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Cancer is the major cause of mortality and morbidity throughout the world where >10 million patients with new cases diagnosed every year. The objective of this study was to prepare and evaluate erlotinib loaded chitosan nanoparticles for their anticancer potential. Also, to study the effect of various formulation variables on prepared nanoparticles using box-behnken design. Erlotinib loaded chitosan nanoparticles were prepared by ionic gelation method using the spray drying technique. It was found that batch SNP-9 has a maximum loading capacity (74.45 ± 0.34%) and entrapment efficiency (43 ± 0.57%) with a particle size 170.2 nm. Analysis of variance (ANOVA) was applied on the particle size, entrapment efficiency and % cumulative drug release to study the fitting and the significance of the model. The batch SNP-9 showed 89.46% and 40.12% drug release after 24 h in 0.1 N HCl and Phosphate Buffer (pH 6.8), respectively. The IC50 value of SNP-9 evaluated on A549 Lung cancer cells was found to be 4.41 μM. The optimized formulation was found stable after the six-month study as no considerable transformation was detected. The optimized formulation released erlotinib slowly in comparison to the marketed tablet formulation. Erlotinib loaded chitosan nanoparticles were prepared successfully using spray drying technique with suitable particle size, entrapment efficiency, drug release. The synthesized and optimized nanoparticles were found to possess activity against cancer cells when evaluated in-vitro.
DOI : 10.1016/j.ijbiomac.2019.08.084
Anahtar Kelimeler : Erlotinib, Box-behnken design, Spray drying
ISSN: 0141-8130
Cilt: 139
Sayfa: 1304-1316
Sınıflandırma :
2
Role of chitosan based nanomedicines in the treatment of chronic respiratory diseases
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
International Journal of Biological Macromolecules
Yayıncı:
Elsevier BV
Yazar(lar) :
Nisha Gulati , Kamal Dua , Harish Dureja
Yıl :
2021
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Chitosan-loaded nanomedicines provide a greater opportunity for the treatment of respiratory diseases. Natural biopolymer chitosan and its derivatives have a large number of proven pharmacological actions like antioxidant, wound healing, immuno-stimulant, hypocholesterolemic, antimicrobial, obesity treatment, anti-inflammatory, anticancer, bone tissue engineering, antifungal, regenerative medicine, anti-diabetic and mucosal adjuvant, etc. which attracted its use in the pharmaceutical industry. As compared to other polysaccharides, chitosan has excellent mucoadhesive characteristics, less viscous, easily modified into the chemical and biological molecule and gel-forming property due to which the drugs retain in the respiratory tract for a longer period of time providing enhanced therapeutic action of the drug. Chitosan-based nanomedicines would have the greatest effect when used to transport poor water soluble drugs, macromolecules like proteins, and peptides through the lungs. In this review, we highlight and discuss the role of chitosan and its nanomedicines in the treatment of chronic respiratory diseases such as pneumonia, asthma, COPD, lung cancer, tuberculosis, and COVID-19.
DOI : 10.1016/j.ijbiomac.2021.06.035
Anahtar Kelimeler : BCG Bacillus Calmette-Guerin, Bacillus Calmette-Guerin, BLVR Biological lung volume reduction, Biological lung volume reduction, CF Cystic fibrosis, Cystic fibrosis, COPD Chronic obstructive pulmonary disease, Chronic obstructive pulmonary disease, COVID-19 Corona virus diseases, Corona virus diseases, CRDs Chronic respiratory diseases, Chronic respiratory diseases, DNA Deoxyribonucleic acid, Deoxyribonucleic acid, DPPH 2, 2-diphenyl-1-picrylhydrazyl., 2, 2-diphenyl-1-picrylhydrazyl., GIT Gastrointestinal Tract, Gastrointestinal Tract, GRAS Generally regarded as safe, Generally regarded as safe, IL Interleukin, Interleukin, MERS-CoV Middle East respiratory syndrome - corona virus, Middle East respiratory syndrome - corona virus, RNA Ribonucleic Acid, Ribonucleic Acid, SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome coronavirus 2, TB Tuberculosis, Tuberculosis, TEM Transmission Electron Microscopy, Transmission Electron Microscopy, TNF Tumor Necrosis Factor, Tumor Necrosis Factor, WHO World health organization, World health organization, XRD X-ray Diffraction, X-ray Diffraction, Chitosan, Respiratory diseases, Nanomedicines, Drug delivery
ISSN: 0141-8130
Cilt: 185
Sayfa: 20-30
3
Formulation and evaluation of controlled-release matrix systems of ciprofloxacin.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Polim Med
Yazar(lar) :
Venkata Ramana Malipeddi , Rajendra Awasthi , Kamal Dua
Konu :
Anti-Bacterial Agents, Chemistry, Pharmaceutical, Ciprofloxacin, Delayed-Action Preparations, Diffusion, Excipients, Kinetics, Polymethacrylic Acids, Tablets
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Ciprofloxacin is a broad-spectrum fluoroquinolone antibacterial drug to which most Gram-negative and many Gram-positive bacteria are highly susceptible. Fluoroquinolones are administered repeatedly, twice a day for 5 days, during the course of therapy. Hence, they require repeated administration. Ciprofloxacin qualifies as a drug candidate for a controlled-release drug delivery system.
DOI : 10.17219/pim/90020
Anahtar Kelimeler : EthocelTM 100 Premium, Eudragit® RS PO, ciprofloxacin hydrochloride, diffusion-controlled, matrix tablet
Sınıflandırma :
4
Why is there an emerging need to look for a suitable drug delivery platform in targeting and regulating microbiota?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Panminerva Med
Yazar(lar) :
Kamal Dua , Gaurav Gupta , Rajendra Awasthi , Dinesh K Chellappan
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.23736/S0031-0808.18.03446-8
Sınıflandırma :
5
Improving the solubility of nevirapine using A hydrotropy and mixed hydrotropy based solid dispersion approach.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Polim Med
Yazar(lar) :
Jyotsana R Madan , Virendra J Kamate , Kamal Dua , Rajendra Awasthi
Konu :
Biological Availability, Citric Acid, Lactose, Mannitol, Nevirapine, Solubility, Urea
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Nevirapine, an antiviral drug, is a potent reverse transcriptase inhibitor (NNRTI). It is used in combination with nucleoside analogues for treatment of HIV type-1 (HIV-1) infection and AIDS. Nevirapine is a BCS class II drug which shows dissolution rate limited absorption.
DOI : 10.17219/pim/77093
Anahtar Kelimeler : mixed hydrotropy, nevirapine, solid dispersion
Sınıflandırma :
6
Nano-antibiotics: a novel approach in treating P. aeruginosa biofilm infections.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Minerva Med.
Yazar(lar) :
Kamal Dua , Gaurav Gupta , Nalamolu Koteswara Rao , Mary Bebawy
Konu :
Anti-Bacterial Agents, Biofilms, Combined Modality Therapy, Humans, Magnetic Field Therapy, Nanocapsules, Nanoparticles, Polymers, Pseudomonas Infections, Pseudomonas aeruginosa, Ultrasonic Therapy
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.23736/S0026-4806.18.05588-X
Sınıflandırma :
7
Targeting MicroRNAs: Promising Future Therapeutics in the Treatment of Allergic Airway Disease.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Crit. Rev. Eukaryot. Gene Expr.
Yazar(lar) :
Kamal Dua , Nicole G Hansbro , Paul S Foster , Philip M Hansbro
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
MicroRNAs (miRNAs) are short noncoding RNAs that control gene expression posttranscriptionally by directly blocking translation of their target mRNAs or by repressing protein production via mRNA destabilization. Investigations into miRNAs began approximately 12 years ago with their discovery in mammalian cells. Still, the involvement of miRNAs in the development of asthma remains unclear, and this topic needs further research to discover various molecular mechanisms responsible for the pathogenesis of asthma and new therapeutic interventions. So far, various miRNAs have been identified in allergic airway disease along with their targets. Our present mini-review highlights the latest information involving the role of miRNAs in asthma.
DOI : 10.1615/CritRevEukaryotGeneExpr.2018022218
Sınıflandırma :
8
Nanotechnology in drug delivery gaining new perspectives in respiratory diseases.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Panminerva Med
Yazar(lar) :
Kamal Dua , Jyotsana R Madan , Dinesh K Chellappan , Gaurav Gupta
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.23736/S0031-0808.18.03442-0
Sınıflandırma :
9
Anticonvulsant activity of Morusin isolated from Morus alba: Modulation of GABA receptor
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Biomedicine & Aging Pathology
Yayıncı:
Elsevier
Yazar(lar) :
Gaurav Gupta , Kamal Dua , Imran Kazmi , Firoz Anwar
Yıl :
2014
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Aim of the study Epilepsy is a complex neurological disorder affecting 50 million of world's total population. Number of medicinal plants has been used to treat the convulsion. In ancient time Morus alba was used to treat epilepsy and mental illness. In Chinese medicine also M. alba is used as neuroprotective herbs. The present study was designed to explore the effect of Morusin, a flavonoid glycoside isolated from M. alba as anticonvulsant activity along with biochemical mechanism. Materials and methods Morusin was isolated from M. alba and acute toxicity study was determined. Anticonvulsant activity of Morusin (5 and 10 mg/kg, i.p.) was studied by using isoniazid (INH) and maximal electroshock (MES)-induced convulsion models; diazepam (5 mg/kg) and phenytoin (20 mg/kg) were used as standards, respectively. Biochemical mechanism was investigated by estimating the GABA level in brain. Results The median lethal dose (LD50) of Morusin was found up to 20 mg/kg. Treatment with Morusin (5 and 10 mg/kg) delayed onset of convulsion and tonic hind limb extension along with duration of tonic-clonic convulsions as well as it significantly reduced mortality in INH and MES-induced convulsion. Rats treated with Morusin (5 and 10 mg/kg) significantly increased level of brain GABA at both doses. Conclusion The findings of current study provide pharmacological credibility to anticonvulsant activity of Morusin. The protection against the convulsions and restoration of GABA level give a suggestion to its probable mechanism of action.
DOI : 10.1016/j.biomag.2013.10.005
Anahtar Kelimeler : Anticonvulsant activity, Morusin, Isoniazid, Maximum electroshock, GABA
ISSN: 2210-5220
Sayı: 1
Cilt: 4
Sayfa: 29-32
10
Development and characterization of solid dispersion-microsphere controlled release system for poorly water-soluble drug
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Drug Delivery and Translational Research
Yazar(lar) :
Venkata Ramana Malipeddi , Kamal Dua , Rajendra Awasthi
Konu :
Pharmaceutical Science
Yıl :
2016
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The present study aimed to improve solubility and prolong the release duration of a poorly soluble drug using a combination of two different types of formulations (solid dispersion and microspheres). The solid dispersions were prepared by fusion method using urea and mannitol as hydrophilic carriers. Microspheres were prepared by solvent evaporation method using Eudragit L-100 (EL100) and Eudragit RS PO (ERS) as rate-controlling polymers. Flurbiprofen (FBP)-urea (1:2) solid dispersion and microspheres of FBP-EL-100-ERS (1:0.25:0.75) were used for the development of controlled release formulation by mixing them in different proportions. The FBP-containing formulations were evaluated for percentage yield, drug content, morphology, in vitro release, and in vivo anti-inflammatory activity. The best selected formulation was further evaluated for the controlled and improved effects. SEM photomicrograph confirmed the spherical shape of microspheres and with particle size in the range of 73.5–85.4 μm. In vitro release of FBP from controlled release formulations indicated that the formulation containing solid dispersion:microspheres (1:0.5) yielded prolonged effect up to 10 h. The release kinetics followed zero-order, and the mechanism of drug release was found to be diffusion rate controlled. This formulation had shown better inhibition of edema of rat paw up to 16 h and identified as a suitable product for controlled delivery of FBP. In conclusion, the concept of using a binary mixture of solid dispersion and microspheres can be used for other drugs that exhibit a poor solubility in stomach pH and a faster release in intestinal pH.
DOI : 10.1007/s13346-016-0307-x
Anahtar Kelimeler : Controlled release, Fusion method, Flurbiprofen, Microspheres, Solid dispersions, Solvent evaporation method, Rat paw edema
ISSN: 2190-393X 2190-3948
Sayı: 5
Cilt: 6
Sayfa: 540-550
11
Dissolution behavior of β-cyclodextrin molecular inclusion complexes of aceclofenac
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Pharmacy and Bioallied Sciences
Yazar(lar) :
Kamal Dua , Kavita Pabreja , M V Ramana , Vinny Lather
Yıl :
2011
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
The objective of the present investigation was to study the effect of β-cyclodextrin (β-CD) on the in vitro dissolution of aceclofenac (AF) from molecular inclusion complexes. Aceclofenac molecular inclusion complexes in 1:1 and 1:2 M ratio were prepared using a kneading method. The in vitro dissolution of pure drug, physical mixtures, and cyclodextrin inclusion complexes was carried out. Molecular inclusion complexes of AF with β-CD showed a considerable increase in the dissolution rate in comparison with the physical mixture and pure drug in 0.1 N HCl, pH 1.2, and phosphate buffer, pH 7.4. Inclusion complexes with a 1:2 M ratio showed the maximum dissolution rate in comparison to other ratios. Fourier transform infrared spectroscopy and differential scanning calorimetry studies indicated no interaction between AF and β-CD in complexes in solid state. Molecular modeling results indicated the relative energetic stability of the β-CD dimer-AF complex as compared to β-CD monomer-AF. Dissolution enhancement was attributed to the formation of water soluble inclusion complexes with β-CD. The in vitro release from all the formulations was best described by first-order kinetics (R2 = 0.9826 and 0.9938 in 0.1 N HCl and phosphate buffer, respectively) followed by the Higuchi release model (R 2 = 0.9542 and 0.9686 in 0.1 N HCl and phosphate buffer, respectively). In conclusion, the dissolution of AF can be enhanced by the use of a hydrophilic carrier like β-CD.
DOI : 10.4103/0975-7406.84457
Anahtar Kelimeler : Aceclofenac, complexes, cyclodextrin, solubility
Cilt: 3
Sayı: 3
Sayfa: 417 - 425
Sınıflandırma :
12
Emerging dermatological symptoms in coronavirus pandemic
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Cosmetic Dermatology
Yazar(lar) :
Gaurav Gupta , Yogendra Singh , Dinesh Chellappan , Kamal Dua
Konu :
Dermatology
Yıl :
2020
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/jocd.13466
ISSN: 1473-2130
Sayı: 9
Cilt: 19
Sayfa: 2447-2448
13
CGI based syslog management system for virtual machines
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Spatial Information Research
Yazar(lar) :
Kamal Dua , Tanupriya Choudhury , Uppara Rajanikanth , Amitava Choudhury
Yıl :
2019
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Undoubtedly, logs are brain of any software system. Development, debugging and upgradation of software applications became much easier due to the logging or auditing concept in computer science field. Virtual Machines also log and timestamp every activity that take place during their runtime. Gathering system details from those lengthy log files is a hectic work for the end-user since single log file contains millennial entries of audited log data. A management system can be very helpful solution and required for the analytical scanning and the visualization of the logged data and thus providing the way to end user for the relevant information about the virtual machines running on the hypervisors. The same system can help developers to gather relevant log entries and presenting data collectively to the end user. This system not only helps in providing and presenting details but also act as an alert system to notify user fatal errors occurred during runtime. Statistical usage information or notification system can further be developed by the means of this syslog system. This paper will present how developers can build an efficient Syslog Management System on the web using the (CGI) Common Gateway Interface in the C programming language and also mentions how CGI environment can be achieved in the Apache Tomcat webserver to build dynamic web tools. Also, it provides basic idea how C can be used effectively in the CGI interface to provide better methods for obtaining and extracting relevant system data.
DOI : 10.1007/s41324-019-00308-7
Anahtar Kelimeler : Apache Tomcat, CGI, Cloud, Log, Syslog, Virtual machines
ISSN: 2366-3286 2366-3294
Sayı: 4
Cilt: 28
Sayfa: 475-486
14
Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Life Sciences
Yayıncı:
Elsevier BV
Yazar(lar) :
Behjat Sheikholeslami , Nga Wing Lam , Kamal Dua , Mehra Haghi
Yıl :
2022
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably advanced drug delivery system due to their unique properties, including their biocompatibility and biodegradability, and their capability to reduce toxicity of encapsulated drugs. The in vivo fate of an encapsulated drug in the form of liposome depends on both the drug and the liposome characteristics and the patient pathophysiology. In this review, the impact of the physicochemical properties of liposomes (lipid composition, size and charge) on their pharmacokinetics (systemic absorption, distribution and clearance) was discussed. In the rest, a comprehensive overview of different mechanisms of liposomal uptake by the cells (fusion, lipid transfer, and endocytosis) was provided. The importance of lipid composition and size of liposomes, cell type, and protein corona for each uptake pathway was explained.
DOI : 10.1016/j.lfs.2022.120574
Anahtar Kelimeler : Liposomes, In vivo, Pharmacokinetics, Cellular uptake, Protein corona, Clearance, ABC Accelerated blood clearance, Accelerated blood clearance, BBB Blood-Brain Barrier, Blood-Brain Barrier, Cmax Maximum concentration, Maximum concentration, CME Clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DOPC 1, 2-dioleoyl-sn-glycero-3-phosphocholine, 1, 2-dioleoyl-sn-glycero-3-phosphocholine, DOPE 1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine, DOTAP 1, 2-dioleoyl-3-trimethylammonium propane, 1, 2-dioleoyl-3-trimethylammonium propane, DPPC 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine, 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPG 1, 2-dipalmitoyl-sn-glycero-3-phosphoglycerol, 1, 2-dipalmitoyl-sn-glycero-3-phosphoglycerol, DSPC 1, 2-istearoyl-sn-glycero-3-phosphocholined, 1, 2-istearoyl-sn-glycero-3-phosphocholined, DSPE 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine, 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine, DSPG 1, 2-distearoyl-sn-glycero-3-phosphoglycerol, 1, 2-distearoyl-sn-glycero-3-phosphoglycerol, MLV Multilamellar vesicle, Multilamellar vesicle, MPS Mononuclear phagocyte system, Mononuclear phagocyte system, MVV Multivesicular vesicle, Multivesicular vesicle, PA Phosphatidic acid, Phosphatidic acid, PC Phosphatidylcholine, Phosphatidylcholine, PE Phosphatidylethanolamine, Phosphatidylethanolamine, PEG Polyethyleneglycol, Polyethyleneglycol, PG Phosphatidylglycerol, Phosphatidylglycerol, PK Pharmacokinetics, Pharmacokinetics, PS Phosphatidylserine, Phosphatidylserine, RES Reticuloendothelial system, Reticuloendothelial system, SUV Small unilamellar vesicle, Small unilamellar vesicle, ULV Unilamellar vesicle, Unilamellar vesicle
ISSN: 0024-3205
Sayfa: 120574
15
Formulation and evaluation of proniosomes containing lornoxicam
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Drug Delivery and Translational Research
Yazar(lar) :
Jyotsana R. Madan , Nitesh P. Ghuge , Kamal Dua
Konu :
Pharmaceutical Science
Yıl :
2016
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Proniosomes are the new generation provesicular drug delivery system of non-ionic surfactant, lecithin and cholesterol which upon reconstitution get converted into niosomes. The objective of current study was to develop stable and sustain transdermal delivery system for lornoxicam. Lornoxicam-loaded topically applied proniosomal gel was formulated, optimized, and evaluated with the aim to deliver drug transdermally. Lornoxicam-loaded proniosomal gels were prepared that contained Lutrol F68 and lecithin as surfactants, cholesterol as a stabilizer, and minimal amount of ethanol and trace water. The resultant lornoxicam-loaded proniosomal gel were assessed for stability and the proniosomes-derived niosomes were characterized for morphology, size, zeta potential, and entrapment efficiency, which revealed that they were suitable for skin application. The coacervation phase separation technique was used in formulation of lornoxicam proniosomal gel and the gel was further assessed for in vitro permeation of lornoxicam through the freshly excised rat skin and the cumulative permeation amount of lornoxicam from proniosome, all exhibited significant increase as compared to 1.0 % lornoxicam-loaded pure gel. The optimized F5 batch had shown maximum entrapment efficiency up to 66.98 %. It has shown sustained drug release for more than 24 h. The skin permeability of proniosomal gel was found to be 59.73 %. The SEM and zeta potential studies showed formation of good and stable vesicles. Thus, proniosomes proved to have better potential for transdermal delivery of lornoxicam over conventional gel formulations.
DOI : 10.1007/s13346-016-0296-9
Anahtar Kelimeler : Proniosomes, Lornoxicam, Lecithin, Entrapment efficiency, Gel
ISSN: 2190-393X 2190-3948
Sayı: 5
Cilt: 6
Sayfa: 511-518
16
Antibacterial and in vitro growth inhibition study of struvite urinary stones using Oxalis corniculata Linn. leaf extract and its biofabricated silver nanoparticles.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Recent Pat Drug Deliv Formul
Yazar(lar) :
Poppy Das , Kiran Kumar , Arunai Nambiraj , Rajendra Awasthi , Kamal Dua , Himaja Malipeddi
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Herbal drugs are gaining exponential scientific recognition due to their distinct advantages. In the last 2-3 decades, a gradual increase in worldwide patents on herbal nano-formulations has been noted to address the solubility and bioavailability issues of phytoceuticals. Struvite or ammonium magnesium phosphate hexahydrate (NH4MgPO4.6H2O) is among the important urinary infection stones causing painful urological ailment. These smaller stones may bind together to form a bigger staghorn calculi. Urinary tract infections caused by some gram positive and gram negative bacteria further enhances the chance of formation of such stones. Oxalis corniculata Linn. is an edible plant, traditionally used in the treatment of bacterial infections and kidney stones. However, there is no scientific evidence to relate the use of O. corniculata against struvite kidney stones. Hence, the antibacterial and struvite stones inhibition activity of the aqueous extract of Oxalis corniculata Linn. leaves and its biofabricated silver nanoparticles (AgNPs) was studied.
DOI : 10.2174/1872211312666180723160624
Anahtar Kelimeler : AgNPs, oxalis corniculata, single diffusion gel growth, struvit.
Sınıflandırma :
17
Targeting bacterial biofilms in pulmonary diseases in pediatric population.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Minerva Pediatr.
Yazar(lar) :
Kamal Dua , Gaurav Gupta , Dinesh K Chellappan , Shakti Shukla , Philip M Hansbro
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.23736/S0026-4946.18.05256-8
Sınıflandırma :
18
Matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of bacteria isolated from pharmaceutical clean rooms.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Interv Med Appl Sci
Yazar(lar) :
Laíse de Oliveira Andrade , Rajendra Awasthi , Kamal Dua , Terezinha de Jesus Andreoli Pinto
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
During the manufacturing of sterile drugs, it is of the utmost importance to meet the minimum requirements for asepsis recommended by the legislations on good manufacturing practices-based efficient environmental monitoring.
DOI : 10.1556/1646.9.2017.40
Anahtar Kelimeler : MALDI-TOF MS identification, bacterial identification, biochemical identification, environmental monitoring, pharmaceutical clean room, rapid microbiological methods
Sınıflandırma :
19
Formulation, optimization, and in vitro evaluation of nanostructured lipid carriers for topical delivery of Apremilast
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Dermatologic Therapy
Yazar(lar) :
Jyotsana R. Madan , Shweta Khobaragade , Kamal Dua , Rajendra Awasthi
Konu :
Dermatology, General Medicine
Yıl :
2020
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This work was aimed to formulate topical Apremilast (APM)‐loaded nanostructured lipid carriers (NLCs) for the management of psoriasis. NLCs were prepared by a cold homogenization technique using Compritol 888ATO, oleic acid, Tween 80 and Span 20, and Transcutol P as a solid lipid, liquid lipid, surfactant mixture, and penetration enhancer, respectively. Carbopol 940 was used to convert NLC dispersion into NLC‐based hydrogel to improve its viscosity for topical administration. The optimized formulation was characterized for size, polydispersity index (PDI), zeta potential (ZP), percentage of entrapment efficiency (%EE), and surface morphology. Furthermore, viscosity, spreadability, stability, in vitro drug diffusion, ex vivo skin permeation, and skin deposition studies were carried out. APM‐loaded NLCs showed a narrow PDI (0.339) with a particle size of 758 nm, a %EE of 85.5%, and a ZP of −33.3 mV. Scanning electron microscopy confirmed spherical shape of NLCs. in vitro drug diffusion and ex vivo skin permeation results showed low drug diffusion, sustained drug release, and 60.1% skin deposition. The present study confirms the potential of the nanostructured lipid form of poorly water‐soluble drugs for topical application and increased drug deposition in the skin.
DOI : 10.1111/dth.13370
ISSN: 1396-0296
Sayı: 3
Cilt: 33

20
Functional relevance of SATB1 in immune regulation and tumorigenesis.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Biomed. Pharmacother.
Yazar(lar) :
Krishna P Sunkara , Gaurav Gupta , Philip M Hansbro , Kamal Dua , Mary Bebawy
Konu :
Animals, Carcinogenesis, Disease Progression, Gene Expression Regulation, Neoplastic, Humans, Immunity, Matrix Attachment Region Binding Proteins, Neoplasms
Yıl :
2018
Kamal Dua
Piri Tam Metin Bulucu
Kaydet Alıntıla
The Special AT-rich Sequence Binding Protein 1 (SATB1) is a chromatin organiser and transcription factor which regulates numerous cellular processes such as differentiation, proliferation and apoptosis through effects on gene expression. SATB1 undergoes various post-translational modifications, which determine its interaction with co-activators and co-repressors to induce regulation of gene transcription. SATB1 is an identified oncogene, its increased expression is associated with poor prognosis in many cancers. This paper provides a review on SATB1-mediated immune responses and on its target genes in the context of tumorigenesis and tumour progression. Specifically, we discuss the role of SATB1 in tumour immunity, Epithelial to Mesenchymal Transition (EMT), metastasis and multidrug resistance. Therapeutic targeting of aberrant SATB1 may be an important strategy in the treatment of cancer.
DOI : 10.1016/j.biopha.2018.05.045
Anahtar Kelimeler : Apoptosis, EMT, Gene expression, Immune responses, Invasion, Metastasis, SATB1, Tumour
Sınıflandırma :
21
Microbiome as therapeutics in vesicular delivery.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Biomed. Pharmacother.
Yazar(lar) :
Gautam Singhvi , Vishal Girdhar , Shalini Patil , Gaurav Gupta , Philip M Hansbro , Kamal Dua
Konu :
Animals, Chemistry, Pharmaceutical, Drug Carriers, Drug Delivery Systems, Humans, Liposomes, Microbiota, Nanoparticles
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Microbiome refers to an ecological community of various symbiotic and pathogenic microorganisms, which plays a crucial role in human health and disease. The concept of novel drug delivery systems particularly the vesicular drug delivery systems is gaining massive attention. This emerging technology has started expanding its horizons in the area of microbiome delivery. This mini-review highlights the role of vesicular systems such as nanoparticles, liposomes etc. as a host/carrier for the microbiome in targeting various diseases. This review will be of interest for both the biological and formulation scientists to understand and explore the new vistas in the area of vesicular delivery system as carrier for microbiome delivery.
DOI : 10.1016/j.biopha.2018.05.099
Anahtar Kelimeler : Biotherapeutics, Disease targeting, Microbiome, Microbiota, Vesicular drug delivery systems
Sınıflandırma :
22
Enhancement of Dissolution Behavior of Aceclofenac by Complexation with β-Cyclodextrin-Choline Dichloride Coprecipitate
Dergi Makalesi

Dergi Makalesi
Kaynak :
Taylor and Francis
Dergi:
Journal of Dispersion Science and Technology
Yayıncı:
Informa UK Limited
Yazar(lar) :
Kamal Dua , Kavita Pabreja , M. V. Ramana
Konu :
Physical and Theoretical Chemistry, Surfaces, Coatings and Films, Polymers and Plastics
Yıl :
2011
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1080/01932691.2010.513317
ISSN: 0193-2691
Sayı: 10
Cilt: 32
Sayfa: 1477-1484
23
Nanoparticles in Cancer Treatment: Opportunities and Obstacles.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Curr Drug Targets
Yazar(lar) :
Rajendra Awasthi , Ariane Roseblade , Philip Michael Hansbro , Michael John Rathbone , Kamal Dua , Mary Bebawy
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
In the United States, the estimated number of new cancer cases in 2018 will be approx. 1.7 million. Historically, combination chemotherapy has been the primary choice of treatment. However, chemotherapeutics have pharmaceutical limitations, among which include problems with stability and aqueous solubility. Likewise, dose limiting toxicity is significant with nonspecific toxicity to healthy cells, hair loss, loss of appetite, peripheral neuropathy and diarrhea being typical side effects. The emergence of Multidrug resistance (MDR) also presents s a significant challenge for the successful treatment of cancer whereby cancer cells become cross resistant to many of the chemotherapeutic agents used. Nanotechnology presents a new frontier for cancer treatment. It holds potential in minimizing systemic toxicity through the development of functionalized particles for targeted treatment. They also provide an alternative strategy to circumvent multidrug resistance as they have a capacity to by-pass the drug efflux mechanism associated with this phenotype. Aside from the advantages they offer in treatment, nanoparticles are also emerging to be valuable diagnostic entities. This article highlights the various ways nanotechnology is being used to improve the treatment and management of cancer. We also discuss the opportunities and obstacles in this area and provide an up to date review of progress in the treatment of cancer.
DOI : 10.2174/1389450119666180326122831
Anahtar Kelimeler : Cancer, MicroRNA, P-glycoprotein, carbon nanotube, cellular targeting, chemotherapy, diagnostics, extracellular vesicles, microparticles, multidrug resistance, nanomedicine, nanoprarticles.
Sınıflandırma :
24
Development and evaluation of solid lipid nanoparticles of mometasone furoate for topical delivery.
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
International Journal of Pharmaceutical Investigation
Yayıncı:
International Journal of Pharmaceutical Investigation
Yazar(lar) :
Kamal Dua , Priyanka A Khude , Jyotsana R Madan
Yıl :
2014
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This article is from International Journal of Pharmaceutical Investigation, volume 4. Abstract Introduction:: Solid lipid nanoparticles (SLNs) are the new generation of submicron sized lipid emulsions where liquid lipid (oil) has been substituted by solid lipid. Lipids used in the formulation are safe, stable and biodegradable in nature. SLNs offer various advantages for topical drug delivery like ability of deposition into skin with the reduced systemic exposure and reduced local side-effects along with providing sustained release of drug. Mometasone furoate (MF) is a topical glucocorticoid having anti-inflammatory, anti-pruritic, anti-hyper proliferative activity. Owing to these properties it is recommended in chronic inflammation and psoriasis. In market, MF cream and lotion (0.1%) are available, which show slight skin irritation, burning and common side-effects due to steroids. Experimental:: To overcome the shortcomings of conventional formulations, there is a need to develop a novel formulation that can reduce these side-effects and show maximum desired effects. Thus, SLN of MF can be prepared, which would help in increasing skin deposition as well as provide sustained release. In this study, SLNs were prepared by solvent - injection method. Results:: The F8 batch had shown maximum entrapment up to55.59% and sustained drug release for more than 8 h. The skin permeability of SLN loaded gel was found to be 15.21times more than that of marketed cream. SLN loaded gel showed 83.52% of skin deposition which was 2.67 times more than marketed cream and 20 times more than plain drug loaded gel. The scanning electron microscopy and zeta potential study showed formation of good SLN dispersion. The stability study showed successful formation of stable SLNs. Thus, SLNs proved the potential for topical delivery of corticosteroid drug over the conventional formulations. Experimental:: To overcome the shortcomings of conventional formulations, there is a need to develop a novel formulation that can reduce these side-effects and show maximum desired effects. Thus, SLN of MF can be prepared, which would help in increasing skin deposition as well as provide sustained release. In this study, SLNs were prepared by solvent - injection method.
DOI : doi:10.4103/2230-973X.133047
Cilt :4
ISSN :2230-973X
Sınıflandırma :
Kimya %29
25
MicroRNAs as biological regulators in skin disorders.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Biomed. Pharmacother.
Yazar(lar) :
Gautam Singhvi , Prachi Manchanda , Vamshi Krishna Rapalli , Sunil Kumar Dubey , Gaurav Gupta , Kamal Dua
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
microRNAs are being investigated as promising therapeutic targets and biomarkers for different disease conditions. miRNAs serve as essential regulators of cell differentiation, proliferation and survival. The involvement of miRNAs in the functioning and regulation of the skin cells and skin diseases is a rapidly advancing area in dermatological research. miRNAs have been identified to play a key role in the pathogenesis, diagnosis, and treatment of the skin diseases. Skin is one of the largest organs of the body, primarily functioning as the first line of defence against external insults including bacteria, virus and other pathogens. Various miRNAs have been identified to demonstrate significant effects in various skin inflammatory conditions such as wounds, cancer, psoriasis, scleroderma, dermatomyositis. The current review explores the possible roles of the miRNAs in skin disorders and reports relating to the clinical trials involving skin diseases and miRNAs. The review has also compiled the information of the databases available, which correlates the miRNAs with different diseases and give details about targeting interactions of miRNA.
DOI : 10.1016/j.biopha.2018.09.090
Anahtar Kelimeler : Dermatomyositis, Psoriasis, Skin disorders, Wound healing, microRNAs, scleroderma
Sınıflandırma :
26
PEPTIDYLARGININE DEIMINASE-4: MEDICO-FORMULATIVE STRATEGY TOWARDS MANAGEMENT OF RHEUMATOID ARTHRITIS
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Biochemical Pharmacology
Yayıncı:
Elsevier BV
Yazar(lar) :
Indhumathi Thirugnanasambandham , Arun Radhakrishnan , Gowthamarajan Kuppusamy , Sachin Kumar Singh , Kamal Dua
Yıl :
2022
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/j.bcp.2022.115040
ISSN: 0006-2952
Sayfa: 115040
27
Emerging landscape in psoriasis management: From topical application to targeting biomolecules.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Biomed. Pharmacother.
Yazar(lar) :
Vamshi Krishna Rapalli , Gautam Singhvi , Sunil Kumar Dubey , Gaurav Gupta , Dinesh Kumar Chellappan , Kamal Dua
Yıl :
2018
Kamal Dua
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Psoriasis is a chronic autoimmune skin disorder affecting 2-3% of the world population. It has characteristic features such as increased keratinocyte proliferation and production of inflammatory mediators. The treatment involves various strategies including topical, systemic, phototherapy and biologics. Topical therapies are preferred for mild to moderate psoriasis conditions over the systemic therapies which are ideal in severe disease conditions. The systemic therapies include immunosuppressants, biological agents and recently approved phosphodiesterase-4 (PDE4) inhibitors. There are various limitations associated with the existing therapies where the new findings in the pathogenesis of psoriasis are paving a path for newer therapeutics to target at the molecular level. Various small molecules, PDE-4 inhibitors, biologics, and immunomodulator proved efficacious including the new molecules targeting Janus kinases (JAK) inhibitors that are under investigation. Furthermore, the role of genetic and miRNAs in psoriasis is still not completely explored and may further help in improving the treatment efficacy. This review provides an insight into various emerging therapies along with currently approved treatments for psoriasis.
DOI : 10.1016/j.biopha.2018.06.136
Anahtar Kelimeler : Biological agents, Janus kinases inhibitors, Keratinocyte, Phosphodiesterase-4(PDE4) inhibitors, Psoriasis, microRNA
Sınıflandırma :
28
Inhaled nano-based therapeutics for inflammatory lung diseases: Recent advances and future prospects
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Life Sciences
Yayıncı:
Elsevier BV
Yazar(lar) :
Nisha Gulati , Dinesh Kumar Chellappan , Ronan MacLoughlin , Kamal Dua , Harish Dureja
Yıl :
2021
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Inflammatory lung diseases related morbidity and mortality impose a significant financial burden. Inflammation is a hallmark of many diseases of the respiratory system which is directly or indirectly linked to adverse health conditions, air pollution, rapid lifestyle changes, and regular outbreaks of microbial infections. The unique anatomical and physiological features of the lungs make them an ideal target organ in the treatment of inflammatory respiratory disease and with the help of inhaled therapy lungs can be targeted directly. The principal objective of this review is to present the comprehensive role of inhaled nano-based therapeutics such as liposomes, niosomes, nanoparticles, nanoemulsion, nanosuspension, and exosomes in the treatment and management of inflammatory respiratory diseases. Inhaled nanomedicines provide targeted diagnosis and treatment, improved drug solubility and distribution, prevent first-pass hepatic metabolism, improved patient compliance, and reduced drug side effects. They overcome several biological barriers in the human body and provide immediate, and quick-onset of action. Future research should be focused on improving the therapeutic efficiency of inhaled nanocarriers and to carry out in-depth mechanistic studies to translate current scientific knowledge for the efficient management of inflammatory lung diseases with minimal or no toxicity.
DOI : 10.1016/j.lfs.2021.119969
Anahtar Kelimeler : Inhalation, Nanomedicines, Inflammation, Lung disorder
ISSN: 0024-3205
Cilt: 285
Sayfa: 119969
29
Phytochemistry and pharmacological activity of the genus artemisia
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Archives of Pharmacal Research
Yazar(lar) :
Dheeraj Bisht , Deepak Kumar , Dharmendra Kumar , Kamal Dua , Dinesh Kumar Chellappan
Konu :
Organic Chemistry, Drug Discovery, Molecular Medicine
Yıl :
2021
Kamal Dua
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Artemisia and its allied species have been employed for conventional medicine in the Northern temperate regions of North America, Europe, and Asia for the treatments of digestive problems, morning sickness, irregular menstrual cycle, typhoid, epilepsy, renal problems, bronchitis malaria, etc. The multidisciplinary use of artemisia species has various other health benefits that are related to its traditional and modern pharmaceutical perspectives. The main objective of this review is to evaluate the traditional, modern, biological as well as pharmacological use of the essential oil and herbal extracts of Artemisia nilagirica, Artemisia parviflora, and other allied species of Artemisia. It also discusses the botanical circulation and its phytochemical constituents viz disaccharides, polysaccharides, glycosides, saponins, terpenoids, flavonoids, and carotenoids. The plants have different biological importance like antiparasitic, antimalarial, antihyperlipidemic, antiasthmatic, antiepileptic, antitubercular, antihypertensive, antidiabetic, anxiolytic, antiemetic, antidepressant, anticancer, hepatoprotective, gastroprotective, insecticidal, antiviral activities, and also against COVID-19. Toxicological studies showed that the plants at a low dose and short duration are non or low-toxic. In contrast, a high dose at 3 g/kg and for a longer duration can cause toxicity like rapid respiration, neurotoxicity, reproductive toxicity, etc. However, further in-depth studies are needed to determine the medicinal uses, clinical efficacy and safety are crucial next steps.
DOI : 10.1007/s12272-021-01328-4
Anahtar Kelimeler : Artemisia, Phytochemical constituents, Essential oil, Sesquiterpenes, Pharmacological activity, COVID-19, Toxicological studies
ISSN: 0253-6269 1976-3786
Sayı: 5
Cilt: 44
Sayfa: 439-474

Yayın Yılı

Sınırla

Doküman Türü
Tümü

Veri Tabanı
Tümü

Dergi İsmi
Tümü

Disiplin
Tümü

Disipline Göre İlgililik

Alt Disiplin
Tümü

Konu
Tümü

Yayıncı
Tümü

Lisan
Tümü

X
Filtreler