Piri Keşif Aracı

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

From the earliest moments of life, contact with the outside world and with other individuals invalidates the sterility of the oral cavity. The oral cavity passes from a sterility condition, that is present only during intrauterine life, to a condition in which a microbiota organizes and evolves itself, accompanying the person throughout their life. Depending on a patient’s age, systemic conditions and/or oral conditions, different characteristics of the oral microbiome are shown. By verifying and analyzing this process it is possible to understand what is at the basis of the etiopathogenesis of some oral pathologies, and also the function of the oral microbiome.

Kaynak 1:

https://doi.org/10.3390/biology9010017 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/biology9010017 arayıcılığı görüntüle.

DOI : 10.3390/biology9010017

Anahtar Kelimeler : oral hygiene, oral cavity, oral surgery, oral health, oral medicine, biofilm, microbiota, dental plaque, tooth socket, dental calculus

ISSN: 2079-7737
Cilt: 9
Sayı: 1
Sayfa: 17

Sınıflandırma :

Tıp ve Halk Sağlığı %91

Diş Hekimliği %100

2

Oral Health: The First Step to Well-Being

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Medicina

Yazar(lar) :

Luca Fiorillo

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Scientific research in the medical field shows this constantly: health starts from the mouth. Having good oral health nowadays is not only aimed at tooth health, but as amply demonstrated in the literature, it is a starting point for the general health and well-being of our body. Retracing the latest scientific findings that demonstrate an interpolation between oral health, oral diseases, and systemic complications, literature support was brought to this manuscript. Oral health, as demonstrated, has potentially multi-organ systemic implications, and as the results of the recent literature demonstrate, these implications range from an insulin resistance, due to a periodontal disease, up to far more complex multi-organ systemic complications involving the cardiovascular system or even neurodegenerative pathology. Therefore, being able to improve oral health could have great systemic implications for the organism, for the prevention of pathologies, and therefore for society and for the quality of life in individuals.

DOI : 10.3390/medicina55100676

Anahtar Kelimeler : oral health, general health, well-being, epidemiology, interdisciplinary, multidisciplinary medicine

Cilt: 55
Sayı: 10
Sayfa: 676

Sınıflandırma :

Tıp ve Halk Sağlığı %74

Diş Hekimliği %99

3

Chlorhexidine Gel Use in the Oral District: A Systematic Review

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Yazar(lar) :

Luca Fiorillo

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Chlorhexidine compounds and their different formulations have been investigated several times, especially in the dentistry field. Chlorhexidine application for mouth rinsing immediately underwent oral contraindications, linked to the possibility of causing pigmentation to the teeth or relating to possible cytotoxic events after oral surgery. The positive effects, however, are considerable and its topical antiseptic action has been widely demonstrated by in vitro and clinical research. That’s the reason for its large application in different fields of dentistry. The aim of this study is to collect all the literature regarding the use of chlorhexidine gel in dentistry and all the numerous applications. The initial search on search engines obtained 232 results; then, following the application of the inclusion criteria there were 24 selected articles. The chlorhexidine gel appliance in the dental daily practice is direct to oral surgery, conservative endodontics, prevention and prophylaxis. The use of chlorhexidine has shown some positive effects, also in the case of systemic diseases prevention. Surely, this topical medicine used both professionally and prescribed for home use, can be considered a great help for the prevention of several oral pathologies with systemic implications too.

Kaynak 1:

https://doi.org/10.3390/gels5020031 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/gels5020031 arayıcılığı görüntüle.

DOI : 10.3390/gels5020031

Anahtar Kelimeler : chlorhexidine, oral surgery, mucosa healing, endodontics, prophylaxis, dentistry, chlorhexidine gel

ISSN: 2310-2861
Cilt: 5
Sayı: 2
Sayfa: 31

Sınıflandırma :

Biyotıp %72

Biyomedikal Mühendisliği ve Biyomühendislik %97

Tıp ve Halk Sağlığı %27

Diş Hekimliği %100

4

Spine and TMJ: A Pathophysiology Report

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Functional Morphology and Kinesiology

Yazar(lar) :

Luca Fiorillo

Yıl :

2020

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The relationship between posture, spine, and temporomandibular joint (TMJ) is still a hotly debated topic in medicine. TMJ takes part in different physiological functions of the organism, starting from its embryological development, it is possible that it influences different vital functions. There is a strong connection between the respiratory tract and dental/maxillary occlusion or anatomy. The altered physiology of this district leads to pathologies that could affect the whole organism. On the contrary, it is also possible to highlight some symptoms of distant organism districts. Knowing well the pathophysiology of this district and semiotics, it is also possible to diagnose pathologies affecting other organs.

Kaynak 1:

https://doi.org/10.3390/jfmk5020024 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/jfmk5020024 arayıcılığı görüntüle.

DOI : 10.3390/jfmk5020024

Anahtar Kelimeler : dentistry, spine, anatomy, posturology, gnathology

ISSN: 2411-5142
Cilt: 5
Sayı: 24
Sayfa: 24

Sınıflandırma :

Tıp ve Halk Sağlığı %97

Diş Hekimliği %76

5

TMJ Dysfunction and Systemic Correlation

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Functional Morphology and Kinesiology

Yazar(lar) :

Luca Fiorillo , Giuseppe Musumeci

Yıl :

2020

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In recent years it has been conclusively shown how the position of the mouth in relation to the body affects the way of walking and standing. In particular, occlusion, the relationship between skull and jaw, swallowing and convergence of the eyes are in neuro-muscular relationship with the control and maintenance system of posture, integrating at different levels. This manuscript aims to be a summary of all the oral, occlusal and articular dysfunctions of TMJ with systemic and postural−muscular repercussions. Recent articles found in the literature that are taken into consideration and briefly analyzed represent an important starting point for these correlations, which are still unclear in the medical field. Posturology, occlusal and oral influences on posture, spine and muscular system are still much debated today. In the literature, there are articles concerning sports performance and dental occlusion or even the postural characteristics of adolescents or children in deciduous and mixed dentition. The temporomandibular joint, as the only joint of the skull, could therefore represent a site to pay particular attention to, and in some cases an ATM dysfunction could be a clue for the diagnosis of systemic pathologies, or it could be the repercussion.

Kaynak 1:

https://doi.org/10.3390/jfmk5010020 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/jfmk5010020 arayıcılığı görüntüle.

DOI : 10.3390/jfmk5010020

Anahtar Kelimeler : dentistry, posturology, systemic disease, syndrome, occlusion, skeletal muscle

ISSN: 2411-5142
Cilt: 5
Sayı: 1
Sayfa: 20

Sınıflandırma :

Tıp ve Halk Sağlığı %80

Diş Hekimliği %80

6

Conscious Sedation in Dentistry

Dergi Makalesi

Kaynak :

MDPI

Dergi:

Medicina

Yayıncı:

MDPI AG

Yazar(lar) :

Luca Fiorillo

Yıl :

2019

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

Invasive dental procedures can be performed only with local anesthesia; in some cases, it may be useful to combine the administration of drugs to obtain anxiolysis with local anesthesia. Sedation required level should be individually adjusted to achieve a proper balance between the needs of the patient, the operator, and the safety of the procedure. Surgical time is an important factor for post-operative phases, and this could be greatly increased by whether the patient interrupts the surgeon or if it is not collaborative. In this manuscript some dentistry-used methods to practice conscious sedation have been evaluated. This manuscript could be a useful reading on the current state of conscious sedation in dentistry and an important starting point for future perspectives. Surely the search for safer drugs for our patients could have beneficial effects for them and for the clinicians.

DOI : 10.3390/medicina55120778

ISSN: 1010-660X
Sayı: 12
Cilt: 55
Sayfa: 778

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Diş Hekimliği %95

7

Chitosan Use in Dentistry: A Systematic Review of Recent Clinical Studies

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Marine Drugs

Yazar(lar) :

Marco Cicciù , Luca Fiorillo , Gabriele Cervino

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

This study aims to highlight the latest marine-derived technologies in the biomedical field. The dental field, in particular, uses many marine-derived biomaterials, including chitosan. Chitosan that is used in different fields of medicine, is analyzed in this review with the aim of highlighting its uses and advantages in the dental field. A literature search was conducted in scientific search engines, using keywords in order to achieve the highest possible number of results. A review of randomized controlled trials (RCT) was conducted to evaluate and process all the relevant results for chitosan and oral health. After a screening and a careful analysis of the literature, there were only 12 results highlighted. Chitosan performs different functions and it is used in different fields of dentistry in a safe and effective way. Among the uses of chitosan, we report on the remineralizing property of chitosan which hardens tissues of the tooth, and therefore its role as a desensibilizer used in toothpastes. According to our systematic review, the use of chitosan has shown better surgical healing of post-extraction oral wounds. Furthermore, some studies show a reduction in bacterial biofilm when used in dental cements. In addition, it has antibacterial, antifungal, hemostatic and other systemic properties which aid its use for drug delivering.

DOI : 10.3390/md17070417

Anahtar Kelimeler : chitosan, dentistry, oral surgery, dental material, marine drugs

ISSN: 1660-3397
Cilt: 17
Sayı: 7
Sayfa: 417

Sınıflandırma :

Tıp ve Halk Sağlığı %30

Diş Hekimliği %77

Aşı %23

Kimya %26

Biyomedikal Mühendisliği ve Biyoteknoloji %94

Biyotıp %25

Biyomedikal Mühendisliği ve Biyomühendislik %90

8

Worldwide 3D Printers against the New Coronavirus

Dergi Makalesi

Kaynak :

MDPI

Dergi:

Prosthesis

Yayıncı:

MDPI AG

Yazar(lar) :

Luca Fiorillo , Teresa Leanza

Yıl :

2020

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

The pandemic caused by the new coronavirus has placed national health systems of different countries in difficulty, and has demonstrated the need for many types of personal protective equipment (PPE). Thanks to the advent of new three-dimensional printing technologies, it was possible to share print files (using stereolithography (stl)) quickly and easily, improve them cooperatively, and allow anyone who possessed the materials, a suitable 3D printer and these files, to print. The possibility of being able to print three-dimensional supports, or complete personal protective equipment has been of incredible help in the management of COVID-19 (Coronavirus Disease 2019). The times and the relatively low costs have allowed a wide diffusion of these devices, especially for the structures that needed them, mainly healthcare facilities. 3D printing, now includes different fields of application, and represents, thanks to the evolution of methods and printers, an important step towards the “digital world”.

DOI : 10.3390/prosthesis2020009

ISSN: 2673-1592
Sayı: 2
Cilt: 2
Sayfa: 87-90

Sınıflandırma :

Tıp ve Halk Sağlığı %30

Kardiyak Görüntüleme %100

9

Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Nature Communications

Yayıncı:

Springer Nature

Yazar(lar) :

Mattia Conte , Luca Fiorillo , Simona Bianco , Andrea M. Chiariello , Andrea Esposito , Mario Nicodemi

Konu :

Biological physics, Chromatin structure, Epigenetics

Yıl :

2020

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule structures are validated against single-cell imaging data, providing evidence that chromosomal architecture is controlled by a thermodynamics mechanism of polymer phase separation whereby chromatin self-assembles in segregated globules by combinatorial interactions of chromatin factors that include CTCF and cohesin. The thermodynamics degeneracy of single-molecule conformations results in broad structural and temporal variability of TAD-like contact patterns. Globules establish stable environments where specific contacts are highly favored over stochastic encounters. Cohesin depletion reverses phase separation into randomly folded states, erasing average interaction patterns. Overall, globule phase separation appears to be a robust yet reversible mechanism of chromatin organization where stochasticity and specificity coexist. The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin depleted cells, and provide evidence that the architecture of the studied loci is controlled by a thermodynamics mechanism of polymer phase separation whereby chromatin self-assembles in segregated globules.

Kaynak 1:

https://www.nature.com/articles/s41467-020-17141-4 arayıcılığı görüntüle.
Kaynak 2:

https://doi.org/10.1038/s41467-020-17141-4 arayıcılığı görüntüle.

DOI : 10.1038/s41467-020-17141-4

ISSN: 2041-1723
Cilt: 11
Sayı: 1
Sayfa: 1-13

Sınıflandırma :

Yaşam Bilimleri %96

Mikrobiyal Genetik ve Genomik %96

10

Sandblasted and Acid Etched Titanium Dental Implant Surfaces Systematic Review and Confocal Microscopy Evaluation

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Materials

Yazar(lar) :

Gabriele Cervino , Luca Fiorillo , Gaetano Iannello , Dario Santonocito , Giacomo Risitano , Marco Cicciù

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The field of dental implantology has made progress in recent years, allowing safer and predictable oral rehabilitations. Surely the rehabilitation times have also been reduced, thanks to the advent of the new implant surfaces, which favour the osseointegration phases and allow the clinician to rehabilitate their patients earlier. To carry out this study, a search was conducted in the Pubmed, Embase and Elsevier databases; the articles initially obtained according to the keywords used numbered 283, and then subsequently reduced to 10 once the inclusion and exclusion criteria were applied. The review that has been carried out on this type of surface allows us to fully understand the features and above all to evaluate all the advantages or not related. The study materials also are supported by a manufacturing company, which provided all the indications regarding surface treatment and confocal microscopy scans. In conclusion, we can say that, thanks to these new surfaces, it has been possible to shorten the time necessary to obtain osseointegration and, therefore, secondary stability on the part of implants. The surfaces, therefore, guarantee an improved cellular adhesion and thanks to the excellent wettability all the biological processes that derive from it, such as increases in the exposed implant surface, resulting in an increase in bone-implant contact (BIC).

DOI : 10.3390/ma12111763

Anahtar Kelimeler : dental implants, surface properties, osseointegration, bone-implant interface

ISSN: 1996-1944
Cilt: 12
Sayı: 11
Sayfa: 1763

Sınıflandırma :

Malzeme Bilimi %72

Doku Mühendisliği %100

11

Biological and Chemo-Physical Features of Denture Resins

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Materials

Yazar(lar) :

Gabriele Cervino , Marco Cicciù , Alan Scott Herford , Antonino Germanà , Luca Fiorillo

Yıl :

2020

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In the dental field, the study of materials has always been the basis of the clinical practice. Over the years, with the evolution of materials, it has been possible to produce safe and predictable prosthetic devices, with ever better aesthetic features, biocompatibility and patient satisfaction. This review briefly analyzes the features of dental resin materials to underline the biological, microbiological and chemo-physical characteristics. The main aim of prosthodontics is to rehabilitate patients and therefore improve their quality of life. Dental resins are the main materials used for the production of dentures. Once solidified, these polymers have different mechanical or surface characteristics. The results of the literature on these characteristics were analyzed and some new brand dental resins, known as modern resin, were subsequently evaluated. The new materials are undoubtedly a step forward in the creation of dental prostheses, and also in all subsequent maintenance phases. This review shows how changing the chemical structure of the resins could have microbiological influences on the growth and management of the biofilm, and also physical influences in terms of its mechanical characteristics. The development of new materials is a constant goal in dentistry in order to obtain increasingly predictable rehabilitations.

Kaynak 1:

https://doi.org/10.3390/ma13153350 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/ma13153350 arayıcılığı görüntüle.

DOI : 10.3390/ma13153350

Anahtar Kelimeler : dental materials, resin, acrylic, biomechanics, dentistry, dentures

ISSN: 1996-1944
Cilt: 13
Sayı: 3350
Sayfa: 3350

Sınıflandırma :

Malzeme Bilimi %38

Doku Mühendisliği %100

Tıp ve Halk Sağlığı %38

Diş Hekimliği %100

12

Stannous Fluoride Effects on Enamel: A Systematic Review

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Biomimetics

Yazar(lar) :

Luca Fiorillo , Gabriele Cervino , Alan Scott Herford , Luigi Laino , Marco Cicciù

Yıl :

2020

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In recent years there has been a lot of talk about toothpastes with a particular chemical compound: stannous fluoride (SnF2). Its presence is currently still highly controversial, as the latter could have negative health effects. The different companies that produce toothpastes express its dosage in ppm. The purpose of this systematic literature review is to analyze all randomized clinical trials in the literature over the last 10 years and to draw clear results on the function of stannous fluoride, for this purpose the authors performed a Mann–Whitney U Test. Materials: The first analysis of the literature produced a number greater than 800 results, subsequently applying the inclusion and exclusion criteria, and following a manual analysis of the results, 26 manuscripts have been obtained. Results: From the results analyzed in this review, it could be shown that stannous fluoride does not present important contraindications, if not those commonly reported for fluorine. A meta-analysis on enamel loss has been conducted, it shows that SnF2 products provide better results with a p < 0.05 value. Conclusion: This compound could have significant effects in favor of erosion and recalcification of the enamel, on the biofilm formation, gingival inflammation, and in addition, it could be an important aid in the removal of tooth stains and halitosis.

Kaynak 1:

https://doi.org/10.3390/biomimetics5030041 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/biomimetics5030041 arayıcılığı görüntüle.

DOI : 10.3390/biomimetics5030041

Anahtar Kelimeler : dentistry, stannous fluoride, toothpaste, enamel, oral health, oral hygiene

ISSN: 2313-7673
Cilt: 5
Sayı: 41
Sayfa: 41

13

Dental Restorative Digital Workflow: Digital Smile Design from Aesthetic to Function

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Dentistry Journal

Yazar(lar) :

Gabriele Cervino , Luca Fiorillo , Alina Vladimirovna Arzukanyan , Gianrico Spagnuolo , Marco Cicciù

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Breakthroughs in technology have not been possible without influencing the medical sciences. Dentistry and dental materials have been fully involved in the technological and information technology evolution, so much so that they have revolutionized dental techniques. In this study, we want to create the first collection of articles on the use of digital techniques and software, such as Digital Smile Design. The aim is to collect all of the results regarding the use of this software, and to highlight the fields of use. Twenty-four articles have been included in the review, and the latter describes the use of Digital Smile Design and, in particular, the field of use. The study intends to be present which dental fields use “digitization„. Progress in this field is constant, and will be of increasing interest to dentistry by proposing a speed of treatment planning and a reliability of results. The digital workflow allows for rehabilitations that are reliable both from an aesthetic and functional point of view, as demonstrated in the review. From this study, the current field of use of Digital Smile Design techniques in the various branches of medicine and dentistry have emerged, as well as information about its reliability.

Kaynak 1:

https://doi.org/10.3390/dj7020030 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.3390/dj7020030 arayıcılığı görüntüle.

DOI : 10.3390/dj7020030

Anahtar Kelimeler : Digital Smile Design, restorative dentistry, dentistry software, dentistry design

ISSN: 2304-6767
Cilt: 7
Sayı: 2
Sayfa: 30

Sınıflandırma :

Eğitim %41

Teknoloji Eğitimi %31

Bilgisayarlar ve Eğitim %29

Psikoloji %22

Psikometri %23

14

Elastics Selector Gauge as Orthodontics Device Applied to Inter-Maxillary Traction during Malocclusion Correction

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Functional Morphology and Kinesiology

Yazar(lar) :

Sergio Sambataro , Salvatore Bocchieri , Luigi Bafumi , Luca Fiorillo , Gabriele Cervino , Marco Cicciù

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Elastics are the simplest device that can be used during a class correction in orthodontics, and despite the simplicity of a latex band, they are very effective and powerful. The resultant inter-maxillary force affects not only the teeth, but even the mandibular position, and consequently the temporomandibular joints (TMJ). The purpose of our work is to simplify the use of elastics, and to reduce the amount of inventory for orthodontists, because there is a lot of merceology available on the market, and different ways of using the elastics. The use of elastics in clinical practice is based on the force extension values, which are given by the manufacturer for the different sizes of the elastics, generally when they are stretched to three times their lumen size. Various configurations allow for the correction of different malocclusions. We propose a new classification and a new device, the elastic selector gauge, in order to allow clinicians to quickly and easily choose the right elastic in all conditions.

DOI : 10.3390/jfmk4030063

Anahtar Kelimeler : elastics, inter-maxillary traction, class II correction, orthodontics, selector gauge

ISSN: 2411-5142
Cilt: 4
Sayı: 3
Sayfa: 63

Sınıflandırma :

Mühendislik %37

15

Growth Factors in Oral Tissue Engineering: New Perspectives and Current Therapeutic Options

Dergi Makalesi

Kaynak :

Hindawi Limited

Dergi:

BioMed Research International

Yayıncı:

Hindawi

Yazar(lar) :

Luca Fiorillo , Gabriele Cervino , Pablo Galindo-Moreno , Alan Scott Herford , Gianrico Spagnuolo , Marco Cicciù

Yıl :

2021

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

The present investigation is aimed at systematically analyzing the recent literature about the innovative scaffold involved in the reconstructive surgeries by applying growth factors and tissue engineering. An extensive review of the contemporary literature was conducted according to the PRISMA guidelines by accessing the PubMed, Embase, and Scopus Elsevier databases. Authors performed the English language manuscript research published from 2003 to 2020. A total of 13 relevant studies were included in the present review. The present systematic review included only papers with significant results about correlation between scaffold, molecular features of growth factor, and reconstructive surgeries in oral maxillofacial district. The initial research with filters recorded about 1023 published papers. Beyond reading and considering of suitability, only 42 and then 36 full-text papers were recorded for the revision. All the researches recorded the possibility of using growth factors on rebuilding atrophic jaws. Different growth factors like morphogenetic factors, cytokines, and inflammatory ones and their application over different scaffold materials were recorded. Further investigations should be required in order to state scientific evidence about a clear advantage of applying tissue engineering for therapeutic purpose.

DOI : https://doi.org/10.1155/2021/8840598

Cilt: 2021
ISSN: 2314-6133

Sınıflandırma :

Tıp ve Halk Sağlığı %96

Ağız ve Çene Cerrahisi %29

Tıbbi Biyokimya %21

16

Finite Element Method and Von Mises Investigation on Bone Response to Dynamic Stress with a Novel Conical Dental Implant Connection

Dergi Makalesi

Kaynak :

Hindawi Limited

Dergi:

BioMed Research International

Yayıncı:

Hindawi

Yazar(lar) :

Luca Fiorillo , Marco Cicciù , Cesare Du2019Amico , Rodolfo Mauceri , Giacomo Oteri , Gabriele Cervino

Yıl :

2020

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

The bioengineering and medical and biomedical fields are ever closer, and they manage to obtain surprising results for the development of new devices. The field of simulations and studies in silica has undergone considerable development in recent years, favoring the advancement of medicine. In this manuscript, a study was carried out to evaluate the force distribution on the implant components (In-Kone® Universal) and on the peri-implant tissues subjected to loading. With the finite element analysis and the Von Mises method, it was possible to evaluate this distribution of forces both at 0 degrees (occlusal force) and at 30 degrees; the applied force was 800 N. The obtained results on this new type of connection and on all the implant components are satisfactory; the distribution of forces appears optimal even on the peri-implant tissues. Surely, studies like this help to obtain ever more performing devices, improving both the clinic and the predictability of rehabilitations.

DOI : https://doi.org/10.1155/2020/2976067

Cilt: 2020
ISSN: 2314-6133

Sınıflandırma :

Mühendislik %61

Biyomalzemeler %70

Teorik ve Uygulamalı Mekanik %20

17

Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Materials

Yazar(lar) :

Gaetano Isola , Marco Matarese , Francesco Briguglio , Vincenzo Grassia , Giacomo Picciolo , Luca Fiorillo , Giovanni Matarese

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The present study evaluated the effects of low-level laser therapy (LLLT) by means of a diode laser in accelerating orthodontic tooth movement (OTM). After extraction of the first upper premolars for orthodontic purpose, 82 maxillary canines which needed distalization were analyzed in 41 enrolled patients (21 males, 20 females, mean age 13.4 ± 2.1 years). On all experimental sites, an orthodontic force of 50/N was applied by a nickel-titanium (NiTi) closed coil spring (G&H, Franklin, IN, USA) in order to obtain the space closure. Using a split mouth randomized design, the test side was treated using a diode laser (Wiser Laser Doctor Smile, Brendola, Italy) operating at 810 nm wavelength in continuous wave mode at both the buccal and palatal side on three points/side (distal, medial and mesial) (1 W output power, continuous wave of 66.7 J/cm2, energy density of 8 J) at baseline and at 3, 7, and 14 days and every 15 days until the space closed. On the control side, the opposite selected canine was treated only using orthodontic traction. The primary outcome chosen was the overall time needed to complete the levelling and closing space, measured on a study cast. The secondary outcome chosen was the evaluation of pain levels related to tooth traction, using a Visual Analogue Scale (VAS), recorded at 3, 7, and 14 days after treatments. The mean space closures of the maxillary canines were comparable between groups [Test, 4.56 mm (95% CI 3.9−4.8); Control, 4.49 mm (95% CI 3.8−4.7), p = 0.456]. The laser group yielded less mean time [84.35 ± 12.34 days (95% CI 79.3−86)] to accomplish space closure compared to the control group [97.49 ± 11.44 days (91.7−102.3)] (p < 0.001). The test side showed a significant reduction in the average range of dental pain at 3 [Test, 5.41 (95% CI 5.1−5.6); Control, 7.23 (95% CI 6.9−7.6), p < 0.001], 7 [Test, 4.12 (95% CI 3.8−4.7); Control, 5.79 (95% CI 5.4−5.8), p < 0.001], and at 14 days [Test, 2.31 (95% CI 1.8−2.3); Control, 3.84 (95% CI 3.3−4.2), p < 0.001] after treatment (p < 0.001). This study demonstrates that the use of LLLT therapy was effective in accelerating tooth movement and reducing pain levels related to OTM.

DOI : 10.3390/ma12132187

Anahtar Kelimeler : laser therapy, diode Laser, orthodontic tooth movement, clinical trial

ISSN: 1996-1944
Cilt: 12
Sayı: 13
Sayfa: 2187

18

Molecular Dynamics simulations of the Strings and Binders Switch model of chromatin

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Methods

Yayıncı:

Elsevier

Yazar(lar) :

Carlo Annunziatella , Andrea M. Chiariello , Andrea Esposito , Simona Bianco , Luca Fiorillo , Mario Nicodemi

Yıl :

2018

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

In recent years interest has grown on the applications of polymer physics to model chromatin folding in order to try to make sense of the complexity of experimental data emerging from new technologies such as Hi-C or GAM, in a principled way. Here we review the methods employed to efficiently implement Molecular Dynamics computer simulations of polymer models, focusing in particular on the String&Binders Switch (SBS) model. The constant improvement of such methods and computer power is returning increasingly more accurate insights on the structure and molecular mechanisms underlying the spatial organization of chromosomes in the cell nucleus. We aim to provide an account of the state of the art of computational techniques employed in this type of investigations and to review recent applications of such methods to the description of real genomic loci, such as the Sox9 locus in mESC.

DOI : 10.1016/j.ymeth.2018.02.024

ISSN: 1046-2023
Cilt: 142
Sayfa: 81-88

Sınıflandırma :

Fizik %51

Parçacık Hızlandırma ve Algılama %21

19

Models of polymer physics for the architecture of the cell nucleus

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Yazar(lar) :

Andrea Esposito , Carlo Annunziatella , Simona Bianco , Andrea M. Chiariello , Luca Fiorillo , Mario Nicodemi

Konu :

Medicine (miscellaneous), Biochemistry, Genetics and Molecular Biology (miscellaneous)

Yıl :

2018

Luca Fiorillo

Özet Ek Bilgiler

Kaydet

The depth and complexity of data now available on chromosome 3D architecture, derived by new technologies such as Hi‐C, have triggered the development of models based on polymer physics to explain the observed patterns and the underlying molecular folding mechanisms. Here, we give an overview of some of the ideas and models from physics introduced to date, along with their progresses and limitations in the description of experimental data. In particular, we focus on the Strings&Binders and the Loop Extrusion model of chromatin architecture.

DOI : 10.1002/wsbm.1444

ISSN: 1939-5094
Sayı: 4
Cilt: 11
Sayfa: e1444

20

A Polymer Physics Investigation of the Architecture of the Murine Orthologue of the 7q11.23 Human Locus

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Neuroscience

Yazar(lar) :

Andrea M. Chiariello , Andrea M. Chiariello , Andrea Esposito , Andrea Esposito , Andrea Esposito , Carlo Annunziatella , Carlo Annunziatella , Simona Bianco , Simona Bianco , Luca Fiorillo , Luca Fiorillo , Antonella Prisco , Mario Nicodemi , Mario Nicodemi , Mario Nicodemi

Yıl :

2017

Luca Fiorillo Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In the last decade, the developments of novel technologies, such as Hi-C or GAM methods, allowed to discover that chromosomes in the nucleus of mammalian cells have a complex spatial organization, encompassing the functional contacts between genes and regulators. In this work, we review recent progresses in chromosome modeling based on polymer physics to understand chromatin structure and folding mechanisms. As an example, we derive in mouse embryonic stem cells the full 3D structure of the Bmp7 locus, a genomic region that plays a key role in osteoblastic differentiation. Next, as an application to Neuroscience, we present the first 3D model for the mouse orthologoue of the Williams–Beuren syndrome 7q11.23 human locus. Deletions and duplications of the 7q11.23 region generate neurodevelopmental disorders with multi-system involvement and variable expressivity, and with autism. Understanding the impact of such mutations on the rewiring of the interactions of genes and regulators could be a new key to make sense of their related diseases, with potential applications in biomedicine.

DOI : 10.3389/fnins.2017.00559

Anahtar Kelimeler : polymer physics, chromatin, Neuroscience, congenital disease, 7q11.23 locus

Cilt: 11

Sınıflandırma :

Biyotıp %97

Sitogenetik %100

21

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Applied Sciences

Yazar(lar) :

Claudio Stacchi , Federico Berton , Luca Fiorillo , Vanessa Nicolin , Teresa Lombardi , Marco Cicciù , Roberto Di Lenarda

Yıl :

2019

Luca Fiorillo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Nowadays implant-prosthetic rehabilitations are one of the best solutions for rehabilitating our patients. These allow obtaining rehabilitations with optimal functional and aesthetic performances. Often patients, who undergo implant-prosthetic therapy, have the conditions of edentulias, single or multiple, that have been going on for some time. This, according to the literature, produces resorption of the alveolar bone, a process that is complicated in the posterior area of the upper arch by a pneumatization of the maxillary sinuses. The loss of vertical height, so that the implant fixtures can be inserted, requires a maneuver called maxillary sinus floor elevation. This procedure, now safely performed with piezoelectric instruments, allows increasing bone height through bone grafting. In this study, the tissue obtained from a patient, after 15 years from the intervention, was evaluated by histological and SEM analyses. The bone healing in the patient has led to a perfect integration between the patient’s bone and the fresh frozen allograft used, however still present and detectable after 15 years.

DOI : 10.3390/app9061119

Anahtar Kelimeler : bone block, sinus floor elevation, bone graft, piezoelectric

ISSN: 2076-3417
Cilt: 9
Sayı: 6
Sayfa: 1119

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Diş Hekimliği %56

Ağız ve Çene Cerrahisi %44

22

Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Antibiotics

Yazar(lar) :

Gabriele Cervino , Marco Cicciù , Antonio Biondi , Salvatore Bocchieri , Alan Scott Herford , Luigi Laino , Luca Fiorillo

Yıl :

2019

Luca Fiorillo