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1
Evaluation of temporomandibular disorders by magnetic resonance imaging
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Radiologia Brasileira
Yazar(lar) :
Natália R. Ferreira , Marcos F. DosSantos
Marcos F. DosSantos
Yayıncı Web Sitesi
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DOI : 10.1590/0100-3984.2019.52.3e2
Cilt: 52
Sayı: 3
2
Positron emission tomography imaging of endogenous mu-opioid mechanisms during pain and migraine
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
PAIN Reports
Yazar(lar) :
Alexandre F. DaSilva , Jon-Kar Zubieta , Marcos F. DosSantos
Yıl :
2019
Marcos F. DosSantos
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Abstract. The enormous advancements in the medical imaging methods witnessed in the past decades have allowed clinical researchers to study the function of the human brain in vivo, both in health and disease. In addition, a better understanding of brain responses to different modalities of stimuli such as pain, reward, or the administration of active or placebo interventions has been achieved through neuroimaging methods. Although magnetic resonance imaging has provided important information regarding structural, hemodynamic, and metabolic changes in the central nervous system related to pain, magnetic resonance imaging does not address modulatory pain systems at the molecular level (eg, endogenous opioid). Such important information has been obtained through positron emission tomography, bringing insights into the neuroplastic changes that occur in the context of the pain experience. Positron emission tomography studies have not only confirmed the brain structures involved in pain processing and modulation but also have helped elucidate the neural mechanisms that underlie healthy and pathological pain regulation. These data have shown some of the biological basis of the interindividual variability in pain perception and regulation. In addition, they provide crucial information to the mechanisms that drive placebo and nocebo effects, as well as represent an important source of variability in clinical trials. Positron emission tomography studies have also permitted exploration of the dynamic interaction between behavior and genetic factors and between different pain modulatory systems. This narrative review will present a summary of the main findings of the positron emission tomography studies that evaluated the functioning of the opioidergic system in the context of pain.
DOI : 10.1097/PR9.0000000000000769
ISSN: 2471-2531
Cilt: 4
Sayı: 4
Sayfa: e769
Sınıflandırma :
3
Reward Circuitry Plasticity in Pain Perception and Modulation
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pharmacology
Yazar(lar) :
Marcos F. DosSantos , Brenda de Souza Moura , Alexandre F. DaSilva
Yıl :
2017
Marcos F. DosSantos
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Although pain is a widely known phenomenon and an important clinical symptom that occurs in numerous diseases, its mechanisms are still barely understood. Owing to the scarce information concerning its pathophysiology, particularly what is involved in the transition from an acute state to a chronic condition, pain treatment is frequently unsatisfactory, therefore contributing to the amplification of the chronic pain burden. In fact, pain is an extremely complex experience that demands the recruitment of an intricate set of central nervous system components. This includes cortical and subcortical areas involved in interpretation of the general characteristics of noxious stimuli. It also comprises neural circuits that process the motivational-affective dimension of pain. Hence, the reward circuitry represents a vital element for pain experience and modulation. This review article focuses on the interpretation of the extensive data available connecting the major components of the reward circuitry to pain suffering, including the nucleus accumbens, ventral tegmental area, and the medial prefrontal cortex; with especial attention dedicated to the evaluation of neuroplastic changes affecting these structures found in chronic pain syndromes, such as migraine, trigeminal neuropathic pain, chronic back pain, and fibromyalgia.
DOI : 10.3389/fphar.2017.00790
Anahtar Kelimeler : chronic pain, reward circuitry, nucleus accumbens, prefrontal cortex, migraine
ISSN: 1663-9812
Cilt: 8
Sınıflandırma :
4
Proceedings #21: Specific Patterns of Current Flow Generated by Different tDCS Montages in the Midbrain and in the Trigeminal Brainstem Sensory Nuclear Complex
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Brain Stimulation
Yayıncı:
Elsevier
Yazar(lar) :
Estevão DaFonseca , Alexandre F. DaSilva , Marom Bikson , Dennis Troung , Marcos F. DosSantos
Yıl :
2019
Marcos F. DosSantos
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Tam Metin
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DOI : 10.1016/j.brs.2018.12.190
ISSN: 1935-861X
Sayı: 2
Cilt: 12
Sayfa: e84-e86
Sınıflandırma :
5
Changes in the vibration sensitivity and pressure pain thresholds in patients with burning mouth syndrome
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
PLOS - Public Library of Science
Dergi:
Public Library of Science
Yazar(lar) :
Maria Elisa Rangel Janini , Marcos F. DosSantos , Natália dos Reis Ferreira , Brenda de Souza Moura
Yıl :
2018
Marcos F. DosSantos
Tam Metin
Kaydet Alıntıla
Objective To investigate the presence of changes in vibration detection and pressure pain threshold in patients with burning-mouth syndrome (BMS). Design of the study Case-control study. The sample was composed of 30 volunteers, 15 with BMS and 15 in the control group. The pressure-pain threshold (PPT) and vibration-detection threshold (VDT) were examined. The clinical evaluation was complemented with the McGill Pain Questionnaire (MPQ), Douleur Neuropathique 4 (DN4) and Beck Depression and Anxiety Inventories (BDI and BAI, respectively). Results BMS subjects showed a statistically significant higher PPT in the tongue (p = 0.002), right (p = 0.001) and left (p = 0.004) face, and a significant reduction of the VDT in the tongue (p = 0.013) and right face (p = 0.030). Significant differences were also found when comparing the PPT and the VDT of distinct anatomical areas. However, a significant interaction (group × location) was only for the PPT. BMS subjects also showed significantly higher levels of depression (p = 0.01), as measured by the BDI, compared to controls; and a significant inverse correlation between the VDT in the left face and anxiety levels was detected. Conclusions The study of somatosensory changes in BMS and its correlations with the clinical features as well as the levels of anxiety and depression expands current understanding of the neuropathic origin and the possible contribution of psychogenic factors related to this disease.
DOI : 10.1371/journal.pone.0197834
Anahtar Kelimeler : Tongue, Depression, Pain sensation, Nerve fibers, Sensory perception, Neuropathic pain, Vibration, Anxiety
Sınıflandırma :
Biyotıp %92
6
Migraine and the Mu-Opioidergic System—Can We Directly Modulate it? Evidence from Neuroimaging Studies
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Current Pain and Headache Reports
Yazar(lar) :
Alexandre F. DaSilva , Thiago D. Nascimento , Marcos F. DosSantos , Jon-Kar Zubieta
Konu :
Anesthesiology and Pain Medicine, Clinical Neurology, General Medicine
Yıl :
2014
Marcos F. DosSantos
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Migraine is a chronic trigeminal pain condition that affects the daily lives of a large part of our population. Its debilitating headache attacks, with increased sensitivity to multiple forms of stimuli, force many patients to rely on over the counter analgesics and resort to abuse of prescription medications, particularly opioid agonists. In the latter case, the indiscriminate medication-driven activation of the opioid system can lead to undesired side effects, such as the augmentation of hyperalgesia and allodynia, as well as the chronification of the attacks. However, we still lack information regarding the impact of migraine attacks and their relief on the function of μ-opioid receptor (μOR) mediated neurotransmission, the primary target of opioid medications. This line of inquiry is of particular importance as this neurotransmitter system is arguably the brain's most important endogenous mechanism involved in pain regulation, and understanding this endogenous mechanism is crucial in determining the effectiveness of opioid medications. Recently, new advances in molecular neuroimaging and neuromodulation have provided important information that can elucidate, in vivo, the role of the endogenous opioid system in migraine suffering and relief.
DOI : 10.1007/s11916-014-0429-0
Anahtar Kelimeler : Migraine, Headache, Brain, Opioid, Neuroimaging, MRI, PET, Neuromodulation, Neurotransmission, tDCS, Stimulation, μOR BPND, Trigeminal, Pain, Allodynia, Chronic, Analgesia
ISSN: 1531-3433 1534-3081
Sayı: 7
Cilt: 18
7
The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Pain Research and Management
Yazar(lar) :
Marcos F. DosSantos , Aleli T. Oliveira , Natália R. Ferreira , Antônio C. P. Carvalho , Paulo Henrique Rosado de Castro
Yıl :
2018
Marcos F. DosSantos
Piri Tam Metin Bulucu
Kaydet Alıntıla
Chronic pain is an important public health issue. Moreover, its adequate management is still considered a major clinical problem, mainly due to its incredible complexity and still poorly understood pathophysiology. Recent scientific evidence coming from neuroimaging research, particularly functional magnetic resonance (fMRI) and positron emission tomography (PET) studies, indicates that chronic pain is associated with structural and functional changes in several brain structures that integrate antinociceptive pathways and endogenous modulatory systems. Furthermore, the last two decades have witnessed a huge increase in the number of studies evaluating the clinical effects of noninvasive neuromodulatory methods, especially transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), which have been proved to effectively modulate the cortical excitability, resulting in satisfactory analgesic effects with minimal adverse events. Nevertheless, the precise neuromechanisms whereby such methods provide pain control are still largely unexplored. Recent studies have brought valuable information regarding the recruitment of different modulatory systems and related neurotransmitters, including glutamate, dopamine, and endogenous opioids. However, the specific neurocircuits involved in the analgesia produced by those therapies have not been fully elucidated. This review focuses on the current literature correlating the clinical effects of noninvasive methods of brain stimulation to the changes in the activity of endogenous modulatory systems.
DOI : 10.1155/2018/2368386
Cilt: 2018
Sınıflandırma :
8
Building up Analgesia in Humans via the Endogenous μ-Opioid System by Combining Placebo and Active tDCS: A Preliminary Report
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
PLOS - Public Library of Science
Dergi:
Public Library of Science
Yazar(lar) :
Alexandre F. DaSilva , Jon-Kar Zubieta , Marom Bikson , Heidi M. Schambra , Misty D. DeBoer , Tiffany M. Love , Thiago D. Nascimento , Ilkka K. Martikainen , Marcos F. DosSantos
Yıl :
2014
Marcos F. DosSantos
Tam Metin
Kaydet Alıntıla
Transcranial Direct Current Stimulation (tDCS) is a method of non-invasive brain stimulation that has been frequently used in experimental and clinical pain studies. However, the molecular mechanisms underlying tDCS-mediated pain control, and most important its placebo component, are not completely established. In this pilot study, we investigated in vivo the involvement of the endogenous μ-opioid system in the global tDCS-analgesia experience. Nine healthy volunteers went through positron emission tomography (PET) scans with [11C]carfentanil, a selective μ-opioid receptor (MOR) radiotracer, to measure the central MOR activity during tDCS in vivo (non-displaceable binding potential, BPND) - one of the main analgesic mechanisms in the brain. Placebo and real anodal primary motor cortex (M1/2mA) tDCS were delivered sequentially for 20 minutes each during the PET scan. The initial placebo tDCS phase induced a decrease in MOR BPND in the periaqueductal gray matter (PAG), precuneus, and thalamus, indicating activation of endogenous μ-opioid neurotransmission, even before the active tDCS. The subsequent real tDCS also induced MOR activation in the PAG and precuneus, which were positively correlated to the changes observed with placebo tDCS. Nonetheless, real tDCS had an additional MOR activation in the left prefrontal cortex. Although significant changes in the MOR BPND occurred with both placebo and real tDCS, significant analgesic effects, measured by improvements in the heat and cold pain thresholds, were only observed after real tDCS, not the placebo tDCS. This study gives preliminary evidence that the analgesic effects reported with M1-tDCS, can be in part related to the recruitment of the same endogenous MOR mechanisms induced by placebo, and that such effects can be purposely optimized by real tDCS.
DOI : 10.1371/journal.pone.0102350
Anahtar Kelimeler : Transcranial direct-current stimulation, Analgesics, Prefrontal cortex, Positron emission tomography, Magnetic resonance imaging, Pain sensation, Thalamus, Neurotransmission
Sınıflandırma :
Biyotıp %100
Nörokimya %89
9
Neuromechanisms of SARS-CoV-2: A Review
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Neuroanatomy
Yazar(lar) :
Marcos F. DosSantos , Marcos F. DosSantos , Marcos F. DosSantos , Sylvie Devalle , Veronica Aran , Daniela Capra , Daniela Capra , Daniela Capra , Natália Roberta Roque , Juliana de Mattos Coelho-Aguiar , Tânia Cristina Leite de Sampaio e Spohr , Tânia Cristina Leite de Sampaio e Spohr , Janice Gonçalves Subilhaga , Cláudia Maria Pereira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Paulo Niemeyer Soares Filho , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto
Yıl :
2020
Marcos F. DosSantos Marcos F. DosSantos Marcos F. DosSantos
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 Piri Tam Metin Bulucu
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Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.
DOI : 10.3389/fnana.2020.00037
Anahtar Kelimeler : SARS-CoV-2, COVID-19, central nervous system, peripheral nervous system, anosmia, dysgeusia
ISSN: 1662-5129
Cilt: 14
Sınıflandırma :
10
Efficacy of viscosupplementation with hyaluronic acid in temporomandibular disorders: A systematic review.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
J Craniomaxillofac Surg
Yazar(lar) :
Natália Ferreira , Danielle Masterson , Rodrigo Lopes de Lima , Brenda de Souza Moura , Aleli T Oliveira , Tatiana Kelly da Silva Fidalgo , Antônio C P Carvalho , Marcos F DosSantos , Eduardo Grossmann
Yıl :
2018
Marcos F DosSantos
Piri Tam Metin Bulucu
Kaydet Alıntıla
To perform a systematic review of the viscosupplementation effectiveness with hyaluronic acid (HA) in the articular Temporomandibular Dysfunctions (TMDs) clinical management.
DOI : 10.1016/j.jcms.2018.08.007
Anahtar Kelimeler : Hyaluronic acid, Osteoarthritis, Systematic review, Temporomandibular dysfunctions, Viscosupplementation
Sınıflandırma :
11
miRNAs: Important Targets for Oral Cancer Pain Research
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
BioMed Research International
Yazar(lar) :
Cláudia Maria Pereira , Dayany Sehnem , Estevão Oliveira da Fonseca , Heráclito Fernando Gurgel Barboza , Antônio Carlos Pires de Carvalho , Alexandre F. M. DaSilva , Vivaldo Moura-Neto , Marcos F. DosSantos
Yıl :
2017
Marcos F. DosSantos
Piri Tam Metin Bulucu
Kaydet Alıntıla
Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cancers. Although the cellular and molecular bases of oral cancer pain have not been fully established yet, the results of recent studies suggest that different epigenetic mechanisms may contribute to this process. For instance, there is strong scientific evidence that microRNAs (miRNAs), small RNA molecules that do not encode proteins, might act by regulating the mechanisms underlying cancer-related pain. Among the miRNAs that could possibly interfere in pain-signaling pathways, miR-125b, miR-181, and miR-339 emerge as some of the most promising candidates. In fact, such molecules apparently contribute to inflammatory pain. Moreover, these molecules possibly influence the activity of endogenous pain control systems (e.g., opioidergic and serotonergic systems), which could ultimately result in peripheral and central sensitization, central nervous system (CNS) phenomena innately associated with chronic pain. This review paper focuses on the current scientific knowledge regarding the involvement of miRNAs in cancer pain, with special attention dedicated to OSCC-related pain.
DOI : 10.1155/2017/4043516
Cilt: 2017
Sınıflandırma :
12
The efficacy of transcranial direct current stimulation and transcranial magnetic stimulation for chronic orofacial pain: A systematic review
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
PLOS - Public Library of Science
Dergi:
Public Library of Science
Yazar(lar) :
Marcos F. DosSantos , Antônio C. Carvalho , Rodrigo L. de Lima , Daniele M. T. P. Ferreira , Tatiana K. S. Fidalgo , Márcio Magini , Thayná A. Menezes , Nathália B. M. Brito , Estevão O. Fonseca , Nathália B. Corrêa , Ygor N. Junqueira , Natália R. Ferreira
Yıl :
2019
Marcos F. DosSantos
Tam Metin
Kaydet Alıntıla
Background Transcranial Direct Current Stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS) have been described as promising alternatives to treat different pain syndromes. This study evaluated the effects of TMS and tDCS in the treatment of chronic orofacial pain, through a systematic review. Methods An electronic search was performed in major databases: MEDLINE, Scopus, Web of Science, Cochrane, Embase, LILACS, BBO, Open Gray and CINAHL. The eligibility criteria comprised randomized clinical trials (RCTs) that applied TMS or tDCS to treat chronic orofacial pain. The variables analyzed were pain, functional limitation, quality of life, tolerance to treatment, somatosensory changes, and adverse effects. The risk of bias was assessed through the Cochrane Collaboration tool, and the certainty of evidence was evaluated through GRADE. The protocol was registered in the PROSPERO database (CRD42018090774). Results The electronic search resulted in 636 studies. Thereafter, the eligibility criteria were applied and the duplicates removed, resulting in eight RCTs (four TMS and four tDCS). The findings of these studies suggest that rTMS applied to the Motor cortex (M1), the dorsolateral prefrontal cortex (DLPFC) and the secondary somatosensory cortex (S2) provide adequate orofacial pain relief. Two studies reported significant pain improvement with tDCS applied over M1 while the other two failed to demonstrate significant effects compared to placebo. Conclusions rTMS, applied to M1, DLPFC or S2, is a promising approach for the treatment of chronic orofacial pain. Moreover, tDCS targeting M1 seems to be also effective in chronic orofacial pain treatment. The included studies used a wide variety of therapeutic protocols. In addition, most of them used small sample sizes, with a high risk of biases in their methodologies, thus producing a low quality of evidence. The results indicate that further research should be carried out with caution and with better-standardized therapeutic protocols.
DOI : 10.1371/journal.pone.0221110
Anahtar Kelimeler : Transcranial magnetic stimulation, Neuropathic pain, Face, Myofascial pain, Transcranial direct-current stimulation, Functional electrical stimulation, Systematic reviews, Jaw
Sınıflandırma :
13
Impact of chronic migraine attacks and their severity on the endogenous μ-opioid neurotransmission in the limbic system
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
NeuroImage: Clinical
Yazar(lar) :
Hassan Jassar , Thiago D. Nascimento , Niko Kaciroti , Marcos F. DosSantos , Theodora Danciu , Robert A. Koeppe , Yolanda R. Smith , Marcelo E. Bigal , Frank Porreca , Kenneth L. Casey , Jon-Kar Zubieta , Alexandre F. DaSilva
Yıl :
2019
Marcos F. DosSantos
Yayıncı Web Sitesi
Kaydet Alıntıla
Objective: To evaluate, in vivo, the impact of ongoing chronic migraine (CM) attacks on the endogenous μ-opioid neurotransmission. Background: CM is associated with cognitive-emotional dysfunction. CM is commonly associated with frequent acute medication use, including opioids. Methods: We scanned 15 migraine patients during the spontaneous headache attack (ictal phase): 7 individuals with CM and 8 with episodic migraine (EM), as well as 7 healthy controls (HC), using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Migraineurs were scanned in two paradigms, one with thermal pain threshold challenge applied to the site of the headache, and one without thermal challenge. Multivariable analysis was performed between the μ-opioid receptor availability and the clinical data. Results: μOR availability, measured with [11C]carfentanil nondisplaceable binding potential (BPND), in the left thalamus (P-value = 0.005) and left caudate (P-value = 0.003) were decreased in CM patients with thermal pain threshold during the ictal phase relative to HC. Lower μOR BPND in the right parahippocampal region (P-value = 0.001) and right amygdala (P-value = 0.002) were seen in CM relative to EM patients. Lower μOR BPND values indicate either a decrease in μOR concentration or an increase in endogenous μ-opioid release in CM patients. In the right amygdala, 71% of the overall variance in μOR BPND levels was explained by the type of migraine (CM vs. EM: partial-R2 = 0.47, P-value<0.001, Cohen's effect size d = 2.6SD), the severity of the attack (pain area and intensity number summation [P.A.I.N.S.]: partial-R2 = 0.16, P-value = 0.031), and the thermal pain threshold (allodynia: partial-R2 = 0.08). Conclusions: Increased endogenous μ-opioid receptor-mediated neurotransmission is seen in the limbic system of CM patients, especially in right amygdala, which is highly modulated by the attack frequency, pain severity, and sensitivity. This study demonstrates for the first time the negative impact of chronification and exacerbation of headache attacks on the endogenous μ-opioid mechanisms of migraine patients. ClinicalTrials.gov identifier: NCT03004313 Keywords: Migraine, PET, Opioid, Central pain, MRI, Thermal pain threshold
ISSN: 2213-1582
Cilt: 23
Sayfa:
Sınıflandırma :
14
A rare case of facial nerve schwannoma masked by a concomitant temporomandibular disorder pain
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Interdisciplinary Neurosurgery
Yazar(lar) :
Natália R. Ferreira , D.D.S. , Aleli T. Oliveira , D.D.S. , Marcos F. DosSantos , D.D.S. , M.S. , Ph.D. , Valéria Battistella , M.D. , M.S. , Paulo R.V. Bahia , M.D. , Ph.D. , Antônio C.P. Carvalho , M.D. , Ph.D. , André Antonio Monteiro , D.D.S. , M.S. , Odont. Dr
Yıl :
2018
Marcos F. DosSantos
Yayıncı Web Sitesi
Kaydet Alıntıla
Facial nerve schwannoma (FNS) is an uncommon benign tumor that arises from the Schwann cells of the facial nerve (FN). Although rare, this is the most frequent type of FN tumor, potentially affecting any segment of the nerve. Nevertheless, a higher incidence of intracranial lesions and a predilection for the geniculate ganglion has been reported. Hearing loss, facial paresis and tinnitus are the most frequent symptoms. Conversely, pain, is not among the most prominent complaints and when present, it can be misdiagnosed as an orofacial pain of other source, including pain due to a temporomandibular disorder (TMD). In this paper, we describe a rare case of a patient presenting a FNS located in the intratemporal part and geniculate ganglion of the FN, which was initially masked by the symptoms of a coexistent TMD. It highlights the importance of considering intracranial tumors in the differential diagnosis of orofacial pains. Keywords: Facial nerve schwannoma, Intracranial tumors, Facial paralysis, Orofacial pain, Temporomandibular disorder
ISSN: 2214-7519
Cilt: 14
Sayfa: 89 - 92
Sınıflandırma :
15
A 70-year-old man with severe deep paroxysmal ear pain
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Interdisciplinary Neurosurgery
Yazar(lar) :
Aleli T. Oliveira , D.D.S. , Natália R. Ferreira , D.D.S. , Marise P.C. Marques , M.D. , M.S. Ph.D. , Ricardo Cunha , Jr. , Paulo R.V. Bahia , M.D. , Ph.D. , Antônio C.P. Carvalho , M.D. , Ph.D. , Marcos F. DosSantos , D.D.S. , M.S. , Ph.D , André A. Monteiro , D.D.S. , M.S.
Yıl :
2017
Marcos F. DosSantos
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1016/j.inat.2016.11.006
ISSN: 2214-7519
Cilt: 7
Sayı: C
Sayfa: 73 - 74
Sınıflandırma :
16
μ ‐Opioid activation in the midbrain during migraine allodynia – brief report II
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Annals of Clinical and Translational Neurology
Yazar(lar) :
Thiago D. Nascimento , Marcos F. DosSantos , Sarah Lucas , Hendrik Holsbeeck , Misty DeBoer , Eric Maslowski , Tiffany Love , Ilkka K. Martikainen , Robert A. Koeppe , Yolanda R. Smith , Jonu2010Kar Zubieta , Alexandre F. DaSilva
Yıl :
2014
Marcos F. DosSantos
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
We investigated in vivo the allodynic response of the central μ‐opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ‐opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid‐late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience.
DOI : 10.1002/acn3.66
ISSN: 2328-9503
Sayı: 6
Cilt: 1
Sayfa: 445-450
17
μ ‐Opioid activation in the prefrontal cortex in migraine attacks – brief report I
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Annals of Clinical and Translational Neurology
Yazar(lar) :
Alexandre F. DaSilva , Thiago D. Nascimento , Marcos F. DosSantos , Sarah Lucas , Hendrik Holsbeeck , Misty DeBoer , Eric Maslowski , Tiffany Love , Ilkka K. Martikainen , Robert A. Koeppe , Yolanda R. Smith , Jonu2010Kar Zubieta
Yıl :
2014
Marcos F. DosSantos
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
We evaluated in vivo the μ‐opioid system during spontaneous episodic migraine headaches. Seven patients were scanned at different phases of their migraine using positron emission tomography with the selective μ‐opioid receptor (μOR) radiotracer [11C]carfentanil. In the ictal phase, there was μOR activation in the medial prefrontal cortex, which was strongly associated with the μOR availability level during the interictal phase. Furthermore, μ‐opioid binding changes showed moderate negative correlation with the combined extension and severity of the attacks. These results indicate for the first time that there is high μOR activation in the migraineurs' brains during headache attacks in response to their pain.
DOI : 10.1002/acn3.65
ISSN: 2328-9503
Sayı: 6
Cilt: 1
Sayfa: 439-444
18
Real-Time Sharing and Expression of Migraine Headache Suffering on Twitter: A Cross-Sectional Infodemiology Study.
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
Journal of Medical Internet Research
Yayıncı:
Journal of Medical Internet Research
Yazar(lar) :
Alexandre F DaSilva , Jon-Kar Zubieta , MaryCatherine A Bender , Leen Khatib , Christine Aiello , Sarah R Lucas , Hendrik van Holsbeeck , Misty DeBoer , Theodora Danciu , Marcos F DosSantos , Thiago D Nascimento , Nasim Maleki , Clas Linnman
Yıl :
2014
Marcos F DosSantos
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This article is from Journal of Medical Internet Research, volume 16. Abstract Background: Although population studies have greatly improved our understanding of migraine, they have relied on retrospective self-reports that are subject to memory error and experimenter-induced bias. Furthermore, these studies also lack specifics from the actual time that attacks were occurring, and how patients express and share their ongoing suffering. Objective: As technology and language constantly evolve, so does the way we share our suffering. We sought to evaluate the infodemiology of self-reported migraine headache suffering on Twitter. Methods: Trained observers in an academic setting categorized the meaning of every single “migraine” tweet posted during seven consecutive days. The main outcome measures were prevalence, life-style impact, linguistic, and timeline of actual self-reported migraine headache suffering on Twitter. Results: From a total of 21,741 migraine tweets collected, only 64.52% (14,028/21,741 collected tweets) were from users reporting their migraine headache attacks in real-time. The remainder of the posts were commercial, re-tweets, general discussion or third person’s migraine, and metaphor. The gender distribution available for the actual migraine posts was 73.47% female (10,306/14,028), 17.40% males (2441/14,028), and 0.01% transgendered (2/14,028). The personal impact of migraine headache was immediate on mood (43.91%, 6159/14,028), productivity at work (3.46%, 486/14,028), social life (3.45%, 484/14,028), and school (2.78%, 390/14,028). The most common migraine descriptor was “Worst” (14.59%, 201/1378) and profanity, the “F-word” (5.3%, 73/1378). The majority of postings occurred in the United States (58.28%, 3413/5856), peaking on weekdays at 10:00h and then gradually again at 22:00h; the weekend had a later morning peak. Conclusions: Twitter proved to be a powerful source of knowledge for migraine research. The data in this study overlap large-scale epidemiological studies, avoiding memory bias and experimenter-induced error. Furthermore, linguistics of ongoing migraine reports on social media proved to be highly heterogeneous and colloquial in our study, suggesting that current pain questionnaires should undergo constant reformulations to keep up with modernization in the expression of pain suffering in our society. In summary, this study reveals the modern characteristics and broad impact of migraine headache suffering on patients’ lives as it is spontaneously shared via social media.
DOI : doi:10.2196/jmir.3265
Cilt :16
ISSN :1439-4456
Sınıflandırma :
19
Gliomas and the vascular fragility of the blood brain barrier
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Cellular Neuroscience
Yazar(lar) :
Luiz Gustavo eDubois , Loraine eCampanati , Cassia eRighy , Isabella eD'Andrea-Meira , Tania Cristina Leite De Sampaio e Spohr , Isabel ePorto-Carreiro , Cláudia Maria Pereira , Joana eBalça-Silva , Suzana Assad Kahn , Marcos F. DosSantos , Marcela de Almeida Rabello Oliveira , Adriana eXimenes-da-Silva , Maria Celeste Lopes , Eduardo eFaveret , Emerson eGasparetto , Vivaldo eMoura-Neto
Yıl :
2014
Marcos F. DosSantos
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Astrocytes, members of the glial family, interact through the exchange of soluble factors or by directly contacting neurons and other brain cells, such as microglia and endothelial cells. Astrocytic projections interact with vessels and act as additional elements of the Blood Brain Barrier (BBB). By mechanisms not fully understood, astrocytes can undergo oncogenic transformation and give rise to gliomas. The tumors take advantage of the BBB to ensure survival and continuous growth. A glioma can develop into a very aggressive tumor, the glioblastoma (GBM), characterized by a highly heterogeneous cell population (including tumor stem cells), extensive proliferation and migration. Nevertheless, gliomas can also give rise to slow growing tumors and in both cases, the afflux of blood, via BBB is crucial. Glioma cells migrate to different regions of the brain guided by the extension of blood vessels, colonizing the healthy adjacent tissue. In the clinical context, GBM can lead to tumor-derived seizures, which represent a challenge to patients and clinicians, since drugs used for its treatment must be able to cross the BBB. Uncontrolled and fast growth also leads to the disruption of the chimeric and fragile vessels in the tumor mass resulting in peritumoral edema. Although hormonal therapy is currently used to control the edema, it is not always efficient. In this review we comment the points cited above, considering the importance of the blood brain barrier and the concerns that arise when this barrier is affected.
DOI : 10.3389/fncel.2014.00418
Anahtar Kelimeler : Blood-Brain Barrier, Exosomes, Glioblastoma, Neural Stem Cells, miRNA, tumor-related epileptic seizures
ISSN: 1662-5102
Cilt: 8
Sınıflandırma :

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