Piri Keşif Aracı

Özet Ek Bilgiler

Kaydet

B cells are the precursors of antibody producing plasma cells that can give rise to the formation of donor-specific antibodies. However, recent data suggest that besides their role in antibody production, B cells participate in antibody-independent responses, potentially leading to allograft rejection or allograft tolerance. The presence of CD20+ B cells in kidney graft biopsies has been shown during severe acute rejection episodes and during chronic rejection. Furthermore, operationally tolerant kidney transplant recipients showed a clear B cell dominated fingerprint of tolerance. Several techniques exist to study B cells on different levels. Numerous classification schemes allow for the distinction of many different B cell subsets using flow cytometry. Regardless, data on B cell subsets during stable graft function, rejection or tolerance remain scarce. To obtain a complete picture of the role of B cells during transplantation, antigen specific B cell assays may be required. Therefore, techniques have now been developed that allow for studying the specificity and frequency of HLA specific B cells. Here, we present an overview of the existent assays, panels and techniques intended to characterize peripheral B cells, and the currently available HLA specific B cell functional assays that may allow for monitoring the humoral alloimmune response in transplant recipients.

DOI : 10.1016/j.trre.2015.02.001

ISSN: 0955-470X
Sayı: 2
Cilt: 29
Sayfa: 45-52

Sınıflandırma :

Tıp ve Halk Sağlığı %83

Nakil Cerrahisi %83

2

Treatment of humoral rejection in kidney transplantation

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Transplantation Reviews

Yayıncı:

Elsevier

Yazar(lar) :

Marta Crespo , Federico Oppenheimer , Jean-Pierre Venetz , Manuel Pascual

Yıl :

2006

Marta Crespo

Özet Ek Bilgiler

Kaydet

Acute antibody-mediated rejection (acute humoral rejection [AHR]) of organ allografts presents most of the time as severe dysfunction with a high risk of allograft loss. Peritubular capillary complement C4d deposition is diagnostic of AHR in kidney allografts and is associated with circulating donor-specific anti-HLA alloantibodies. Removal of alloantibodies with suppression of antibody production and rejection reversal is now possible. Therapeutic strategies that include combinations of plasmapheresis (or immunoadsorption), mycophenolate mofetil, tacrolimus, and/or intravenous immunoglobulins have been used to successfully treat AHR. The optimal protocol to treat humoral rejection remains to be defined. Anti-CD20 monoclonal antibody therapy (rituximab) aiming at depleting B cells and suppressing antibody production has been used as a rescue therapy in some episodes of refractory humoral rejection. Plasmapheresis and/or intravenous polyclonal immunoglobulin, as well as rituximab, have also been used to successfully “desensitize” selected high-immunologic risk patients who were in anticipation of crossmatch-positive (or ABO-incompatible) kidney transplantation. Recent data suggest that chronic kidney allograft rejection might also be monitored by complement C4d in biopsies. The efficacy and safety of immunosuppressive drugs such as tacrolimus, mycophenolate mofetil (or enteric-coated mycophenolic acid), sirolimus, or everolimus in controlling antidonor humoral responses in patients with chronic allograft dysfunction remains to be studied prospectively. The combination of tacrolimus and mycophenolate mofetil appears to effectively suppress antidonor antibody production. In the near future, the possible role of specific anti–B-cell approaches with drugs, such as rituximab, or possibly of new anti–T-cell activation approaches using selective agents such as belatacept should be assessed to refine the management of chronic allograft dysfunction.

DOI : 10.1016/j.trre.2006.05.005

ISSN: 0955-470X
Sayı: 2
Cilt: 20
Sayfa: 95-103

Sınıflandırma :

Tıp ve Halk Sağlığı %96

Nakil Cerrahisi %100

3

Expressió de ZAP-70 en linfòcits B normals i síndromes limfoproliferatives B

Tez

Kaynak :

The Dart-Europe

Dergi:

Universitat de Barcelona

Yazar(lar) :

Marta Crespo Maull

Yıl :

2006

Marta Crespo Maull

Ek Bilgiler

Kaydet

Sınıflandırma :

Dilbilim %54

Dil Politikası ve Planlama %95

Biyotıp %32

Popüler Yaşam Bilimleri %82

4

Estudio de la respuesta inmune humoral post-trasplante renal: Rechazo agudo humoral.

Tez

Kaynak :

The Dart-Europe

Dergi:

Universitat de Barcelona

Yazar(lar) :

Marta Crespo Barrio

Yıl :

2002

Marta Crespo Barrio

Ek Bilgiler

Kaydet

Sınıflandırma :

Dilbilim %100

Tercüme %100

5

Chronic renal allograft injury: early detection, accurate diagnosis and management

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Transplantation Reviews

Yayıncı:

Elsevier

Yazar(lar) :

Julio Pascual , Maria J. Pérez-Sáez , Marisa Mir , Marta Crespo

Yıl :

2012

Marta Crespo

Özet Ek Bilgiler

Kaydet

Chronic renal allograft injury (CRAI) is a multifactorial clinical/pathological entity characterised by a progressive decrease in glomerular filtration rate, generally associated with proteinuria and arterial hypertension. Classical views tried to distinguish between immunological (sensitization, low HLA compatibility, acute rejection episodes) and non-immunological factors (donor age, delayed graft function, calcineurin inhibitors [CNI] toxicity, arterial hypertension, infections) contributing to its development. Defining it as a generic idiopathic entity has precluded more comprehensive attempts for therapeutic options. Consequently, it is necessary to reinforce the diagnostic work-up to add etiopathogenetic diagnosis in any case of graft dysfunction, specially transplant vasculopathy and transplant glomerulopathy, reserving the term interstitial fibrosis and tubular atrophy (IFTA) when a case of CRAI is unspecific and no clear contributing factors or a specific etiology is possible in diagnosis. Earlier detection and intervention of CRAI remain as key challenges for transplant physicians. Changes in SCr levels and proteinuria often occur late in disease progression and may not accurately represent the underlying renal damage. Deterioration of renal function over time, determined through slope analysis, is a more accurate indicator of CRAI, and earlier identification of renal deterioration may prompt earlier changes in immunosuppressive therapies. The crucial point is probably to distinguish between nonimmunological or toxic CRAI and immunological-derived CRAI cases. Conversion to nonnephrotoxic immunosuppressants, such as mTOR inhibitors, holds promise in reducing the impact of toxic CRAI by both avoiding and reducing the impact of CNIs and reducing smooth muscle cell proliferation in the kidney. CRAI due to chronic antibody mediated rejection is an important entity, better and better defined that carries a bad prognosis and is associated with graft loss. The best prevention is adequate immunosuppression and tight patient monitoring, from the clinical, analytical and histological standpoint. While clinical trial evidence is needed for early detection and intervention in patients with CRAI, this review represents the current knowledge upon which clinicians can base their strategies. New prospective, ideally well-controlled trials are needed to establish the usefulness of different potentially therapeutic regimens. These evidences should demonstrate the benefits before extended uncontrolled use of drugs such as rituximab, bortezomib or eculizumab, which are expensive and frequently iatrogenic.

DOI : 10.1016/j.trre.2012.07.002

Anahtar Kelimeler : Chronic allograft injury, Chronic allograft nephropathy, Chronic allograft rejection, Nephrotoxicity, Calcineurin inhibitors, mTOR inhibitors

ISSN: 0955-470X
Sayı: 4
Cilt: 26
Sayfa: 280-290

Sınıflandırma :

Tıp ve Halk Sağlığı %86

Nakil Cerrahisi %83

6

Gene expression profiling in chronic lymphocytic leukaemia

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Best Practice & Research Clinical Haematology

Yayıncı:

Elsevier

Yazar(lar) :

Carles Codony , Marta Crespo , Pau Abrisqueta , Emili Montserrat , Francesc Bosch

Yıl :

2009

Marta Crespo

Özet Ek Bilgiler

Kaydet

The proliferation of new techniques that allow a multiparametric study of gene expression, the mutational state of genomic DNA, DNA methylation and the phosphorylation of receptor and adaptor proteins has led to an increased understanding of the origin of different cancers, the definition of new prognosis markers and the response to treatment profiles. Gene profiling studies on chronic lymphocytic leukaemia (CLL) are at the origin of new prognosis markers such as zeta-associated protein-70 (ZAP-70), LPL and CLLU1, which, at present, are under study for their application to clinical practice. An increased resolution in the mutational state at genomic level has underscored the importance of deletion 13q14 at the origin of CLL and 13q and 17p in response to treatment. Some new insights regarding changes in gene expression in CLL cells depending on the microenvironment have been described, but more work is yet to be done in the field.

DOI : 10.1016/j.beha.2009.05.006

Anahtar Kelimeler : chronic lymphocytic leukaemia, gene profiling, ZAP-70, miR-15, LPL, CLLU1, PEG10, del13q14

ISSN: 1521-6926
Sayı: 2
Cilt: 22
Sayfa: 211-222

7

Stratifying the humoral risk of candidates to a solid organ transplantation: a proposal of the ENGAGE working group

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Transplant International

Yazar(lar) :

Oriol Bestard , Lionel Couzi , Marta Crespo , Nicos Kessaris , Olivier Thaunat

Konu :

Transplantation

Yıl :

2021

Marta Crespo

Özet Ek Bilgiler

Kaydet

Detection of circulating antibodies directed against human leukocyte antigen (HLA) molecules, which corresponds to the current definition of ‘sensitized patient’, has been shown to have a severe impact on both access to transplantation and, if the anti‐HLA antibodies are specific to the selected donor, survival of the graft. However, not all donor‐specific antibodies (DSA) are equally harmful to the graft and progress in the understanding of humoral memory has led to the conclusion that absence of DSA at transplantation does not rule out the possibility that the patient has a preformed cellular humoral memory against the graft (thereby defining a category of DSA‐negative sensitized recipients). Technological progress has led to the generation of new assays that offer unprecedented precision in exploring the different layers (serological and cellular) of alloimmune humoral memory. Based on this recent knowledge, the EuropeaN Guidelines for the mAnagement of Graft rEcipients (ENGAGE) working group to propose an updated definition of sensitization in candidates for solid organ transplantation – one that moves away from the current binary division towards a definition based on homogenous strata with similar humoral risk.

DOI : 10.1111/tri.13874

ISSN: 0934-0874

8

Effectiveness of antismoking drug treatment in patients with psychiatric comorbidity compared with patients without this comorbidity.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

J Egypt Public Health Assoc

Yazar(lar) :

Raul Mayoral , F González , Javier Ruiz , Marta Crespo , Ana Molina , Pedro López , Jose Montes

Konu :

Adult, Comorbidity, Female, Humans, Male, Mental Disorders, Middle Aged, Retrospective Studies, Sex Distribution, Smoking, Smoking Cessation, Smoking Prevention, Spain, Treatment Outcome, Young Adult

Yıl :

2018

Marta Crespo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

There is a relationship between smoking and some psychiatric disorders, and there is doubt whether antismoking treatment will be more complex because of psychiatric disorder.

DOI : 10.21608/epx.2018.8943

Anahtar Kelimeler : Bupropion, failure, nicotine replacement therapy, psychiatric comorbidity, relapse, smoking, smoking cessation, treatment success, varenicline

Sınıflandırma :

Tıp ve Halk Sağlığı %98

Adli Psikiyatri %53

Psikiyatri %24

9

Promising activity of selinexor in the treatment of a patient with refractory diffuse large B-cell lymphoma and central nervous system involvement.

Dergi Makalesi

Kaynak 1:

PubMed

Kaynak 2:

PubMed

Dergi:

Haematologica

Yazar(lar) :

Sabela Bobillo , Pau Abrisqueta , Cecilia Carpio , Priyanka Raheja , Josep Castellví , Marta Crespo , Francesc Bosch

Yıl :

2018

Marta Crespo

Yayıncı Web Siteleri

Piri Tam Metin Bulucu Ek Bilgiler

Kaydet

Kaynak 1:

https://www.ncbi.nlm.nih.gov/pubmed/14732865 arayıcılığı görüntüle.
Kaynak 2:

https://www.ncbi.nlm.nih.gov/pubmed/14732865 arayıcılığı görüntüle.

DOI : 10.3324/haematol.2017.181636

Sınıflandırma :

Romatoloji %19

10

Dual kidney transplantation as a strategy to use expanded criteria donors: a systematic review.

Dergi Makalesi

Kaynak 1:

PubMed

Kaynak 2:

Wiley Online Library

Dergi:

Transpl. Int.

Yazar(lar) :

Nuria Montero , Dolores Redondo-Pachón , María José Pérez-Sáez , Marta Crespo , Josep M Cruzado , Julio Pascual

Konu :

Donor Selection, Humans, Kidney Function Tests, Kidney Transplantation

Yıl :

2018

Marta Crespo

Yayıncı Web Siteleri

Piri Tam Metin Bulucu Özet

Kaydet

The objective of this review was to assess whether dual kidney transplantation (DKT) is better than single KT (SKT) for optimizing the use of expanded criteria donor kidneys. We did a systematic literature search and meta-analyses when possible, pooling data for calculating relative risks (RR) of major outcomes. Twenty-five studies met the inclusion criteria. One-year serum creatinine was better after DKT vs. SKT (mean difference -0.27 [-0.37, -0.17], P < 0.001), with less incidence of acute rejection (RR 0.66 [0.52, 0.85], P < 0.001) and without differences at five years. Less DGF was seen in DKT (RR 0.88 [0.76, 1.02], P = 0.09). Mortality at 1 and 3 years was similar after dual or SKT, but mortality at five years was lower after DKT (RR 0.71 [0.53, 0.94], P = 0.02). One-year graft loss was similar between dual (n = 4158) and SKT (n = 51 800) (RR 0.97 [0.87, 1.09], P = 0.62). Three- and five-year graft loss was not considered because of high heterogeneity between studies. In conclusion, short-term graft function and long-term patient survival are better in recipients receiving DKT vs. SKT. However, these differences are based on few retrospective reports with a relatively low number of cases. Good quality randomized controlled trials are needed to assess whether the investment of two kidneys in one recipient is justified in face of the current organ shortage.

Kaynak 1:

https://www.ncbi.nlm.nih.gov/pubmed/29582474 arayıcılığı görüntüle.
Kaynak 2:

https://onlinelibrary.wiley.com/doi/10.1111/tri.13157 arayıcılığı görüntüle.

DOI : 10.1111/tri.13157

Anahtar Kelimeler : dual, kidney transplantation, mortality, survival, systematic review

11

Sex differences in cancer risk and outcomes after kidney transplantation

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Transplantation Reviews

Yayıncı:

Elsevier BV

Yazar(lar) :

Anna Buxeda , Dolores Redondo-Pachón , María José Pérez-Sáez , Marta Crespo , Julio Pascual

Yıl :

2021

Marta Crespo

Özet Ek Bilgiler

Kaydet

Kidney transplant recipients (KTRs) experience a two- to four-fold increased risk of developing and dying from cancer compared with the general population. High cancer risk results from the interaction of both modifiable and non-modifiable factors. This mapping review explores the impact of sex disparity on cancer's increased incidence and mortality after kidney transplantation (KT). In terms of age, population-based studies indicate that younger recipients of both sexes experience a higher risk of cancer, but this is more pronounced in young women. On the contrary, older men are more likely to be diagnosed with cancer, although their increased risk is not statistically significant compared with the general population. Regarding cancer type, studies show an increased risk of Kaposi sarcoma, gynecologic and lung cancer in women, and bladder and kidney cancer in men. Immune-related cancers such as pos-transplant lymphoproliferative disorders and melanoma are increased in both sexes. Mortality also shows differences between sexes. Although cancer is the second cause of death in both male and female KTRs, studies show higher overall mortality in men and elderly recipients. However, the relative risk of cancer mortality compared with the general population is higher at a younger age, with disparate results regarding sex. Female KTRs appear to die at a younger age than males when compared with the general population. Differences in cancer rates by sex after renal transplantation need further studies. A better understanding of sex-specific differences in cancer epidemiology after KT could help nephrologists to better address pre-transplant counseling, to establish early surveillance programs, and to plan modifiable risk factors such as immunosuppression.

DOI : 10.1016/j.trre.2021.100625

Anahtar Kelimeler : Cancer, Gender, Kidney transplantation, Risk factor, Sex, ANZDATA Australia and New Zealand Dialysis and Transplant Registry, Australia and New Zealand Dialysis and Transplant Registry, CKD Chronic kidney disease, Chronic kidney disease, CNI Calcineurin inhibitor, Calcineurin inhibitor, EBV Epstein-Barr virus, Epstein-Barr virus, FOBT Fecal occult blood test, Fecal occult blood test, GLOBOCAN Global Cancer Observatory, Global Cancer Observatory, HPV Human papillomavirus, Human papillomavirus, HR Hazard ratio, Hazard ratio, KDIGO Kidney Disease Improving Global Outcomes, Kidney Disease Improving Global Outcomes, KT Kidney transplantation, Kidney transplantation, KTRs Kidney transplant recipients, Kidney transplant recipients, MRR Mortality rate ratio, Mortality rate ratio, mTORi Mammalian target of rapamycin inhibitor, Mammalian target of rapamycin inhibitor, NMSC Non-melanoma skin cancer, Non-melanoma skin cancer, PAP Papanicolaou, Papanicolaou, PSA prostatic specific antigen., prostatic specific antigen., PTLD Post-transplant lymphoproliferative disorders, Post-transplant lymphoproliferative disorders, PTM Post-transplant malignancies, Post-transplant malignancies, rATG Rabbit antithymocyte globulin, Rabbit antithymocyte globulin, RCT Randomized clinical trials, Randomized clinical trials, SMR Standardized mortality ratio, Standardized mortality ratio, SIR Standardized incidence ratio, Standardized incidence ratio, SRR Standardized rate ratio, Standardized rate ratio

ISSN: 0955-470X
Sayı: 3
Cilt: 35
Sayfa: 100625

12

Steroid avoidance or withdrawal for pancreas and pancreas with kidney transplant recipients

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Cochrane Database of Systematic Reviews

Yazar(lar) :

Nuria Montero , Angela C Webster , Ana Royuela , Javier Zamora , Marta Crespo Barrio , Julio Pascual

Yıl :

2014

Marta Crespo Barrio

Ek Bilgiler

Kaydet

DOI : 10.1002/14651858.cd007669.pub2

ISSN: 1465-1858

13

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Cytometry Part B: Clinical Cytometry

Yazar(lar) :

Francesc Bosch , Ana Muntañola , Eva Giné , Ana Carrió , Neus Villamor , Carolina Moreno , Marta Crespo , Emili Montserrat

Konu :

Pathology and Forensic Medicine, Cell Biology, Histology

Yıl :

2006

Marta Crespo

Özet Ek Bilgiler

Kaydet

Chronic lymphocytic leukemia (CLL) is a disease with an extremely heterogeneous prognosis. Because of this and because of the lack of a truly effective therapy, treatment of CLL must be adapted to the individual risk of each patient. Over the last quarter of century, prognosis of patients with CLL has been based on clinical features. In the last few years a number of biological prognostic parameters have been identified. Among them, the expression of ZAP‐70 in neoplastic B lymphocytes is increasingly being recognized as of paramount importance to predict outcome. Patients with a low percentage (<20%) of ZAP‐70 positive neoplastic B lymphocytes have a much better prognosis that those with a higher proportion (>20%) of ZAP‐70 positive neoplastic B lymphocytes. © 2006 International Society for Analytical Cytology

DOI : 10.1002/cyto.b.20131

ISSN: 1552-4949
Sayı: 4
Cilt: 70B
Sayfa: 214-217

Sınıflandırma :

Tıp ve Halk Sağlığı %58

Alerji %27

Biyotıp %42

Hematoloji %60

14

Management of the SARS-CoV-2 (COVID-19) coronavirus epidemic in hemodialysis units

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Nefrología (English Edition)

Yazar(lar) :

María Dolores Arenas , Judit Villar , Cristina González , Higinio Cao , Silvia Collado , Marta Crespo , Juan Pablo Horcajada , Julio Pascual

Yıl :

2020

Marta Crespo

Özet Ek Bilgiler

Kaydet

The current outbreak of SARS-CoV-2 represents a special risk for renal patients due to their comorbidities and advanced age. The usual performance of hemodialysis treatment s in collective rooms increases the risk. The specific information at this time in this regard is very limited. This manuscript includes a proposal for action to prevent infection in the Nephrology Services, and in particular in hemodialysis units, with the objective of early identification of patients who meet the definition of a suspected case of infection by SARS-CoV-2 and propose circuits and mechanisms to carry out hemodialysis treatments. They are recommendations in continuous review and can be modified if the epidemiological situation, the diagnostic and therapeutic options so require. Resumen: La epidemia de SARS-CoV-2 representa un riesgo especial para los pacientes renales por su condición de personas con comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas. La información específica en el momento actual al respecto es muy limitada. El presente manuscrito recoge una propuesta de actuación para prevenir la infección en los Servicios de Nefrología, y en particular en las Unidades de Hemodiálisis, con el objetivo de identificar precozmente aquellos pacientes que cumplan con la definición de caso sospechoso de infección por el SARS-CoV-2 y proponer circuitos y mecanismos para administrarles el tratamiento con hemodiálisis. Son recomendaciones en continua revisión y podrán ser modificadas si la situación epidemiológica y las opciones diagnóstico-terapéuticas así lo requieren.

Anahtar Kelimeler : Hemodiálisis, SARS-CoV-2, COVID-19, Coronavirus

ISSN: 2013-2514
Cilt: 40
Sayı: 3
Sayfa: 258 - 264

15

Factors associated with renal function compensation after donor nephrectomy.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Nefrologia

Yazar(lar) :

Carla Burballa , Marta Crespo , Dolores Redondo-Pachón , María José Pérez-Sáez , Carlos Arias-Cabrales , Marisa Mir , Albert Francés , Lluís Fumadó , Lluís Cecchini , Julio Pascual

Yıl :

2018

Marta Crespo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Kidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood.

DOI : 10.1016/j.nefro.2018.02.008

Anahtar Kelimeler : Donante renal vivo, Función renal, Living kidney donor, Nefrectomía, Nephrectomy, Renal compensation rate, Renal function, Tasa compensación renal

Sınıflandırma :

Nefroloji %81

Nakil Cerrahisi %19

16

Membrane Attack Complex and Factor H in Humans with Acute Kidney Injury.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Kidney Blood Press. Res.

Yazar(lar) :

Eva Rodríguez , Javier Gimeno , Carlos Arias-Cabrales , Clara Barrios , Dolores Redondo-Pachón , María José Soler , Marta Crespo , Adriana Sierra-Ochoa , Marta Riera , Julio Pascual

Yıl :

2018

Marta Crespo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Complement system seems to play an important role in the pathogenesis of Acute Kidney Injury (AKI). The aim of this study was to investigate the role of complement system in the pathogenesis of human AKI. For this purpose, we studied Membrane Attack Complex (MAC) and factor H in plasma and kidney tissue in AKI.

DOI : 10.1159/000494680

Anahtar Kelimeler : AKI, Complement System, Factor H, Membrane Attack Complex (MAC)

Sınıflandırma :

Tıp ve Halk Sağlığı %89

Nefroloji %100

17

Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Scientific Reports

Yazar(lar) :

Júlia Carabia , Cecilia Carpio , Pau Abrisqueta , Isabel Jiménez , Noelia Purroy , Eva Calpe , Carles Palacio , Francesc Bosch , Marta Crespo

Yıl :

2017

Marta Crespo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Abstract Chronic lymphocytic leukemia (CLL) cells are highly dependent on microenvironment, being the BCR pathway one key player in this crosstalk. Among proteins participating, ZAP-70 enhances response to microenvironmental stimuli. MicroRNA-21 (miR-21) is overexpressed in diverse neoplasias including CLL, where it has been associated to refractoriness to fludarabine and to shorter time to progression and survival. To further elucidate the role of ZAP-70 in the biology of CLL, we studied its involvement in miR-21 regulation. MiR-21 expression was higher in CLL cells with high ZAP-70. Ectopic expression of ZAP-70 induced transcription of miR-21 via MAPK and STAT3, which subsequently induced downregulation of tumor suppressors targeted by miR-21. The co-culture of primary CLL cells mimicking the microenvironment induced ZAP-70 and miR-21 expression, as well as downregulation of miR-21 targets. Interestingly, the increase in miR-21 after co-culture was significantly impaired by ibrutinib, indicating that the BCR signaling pathway is involved in its regulation. Finally, survival of CLL cells induced by the co-culture correlated with miR-21 upregulation. In conclusion, stimuli from the microenvironment regulate miR-21 and its targeted tumor suppressor genes via a signaling pathway involving ZAP-70, thus contributing to the cytoprotection offered by the microenvironment particularly observed in CLL cells expressing ZAP-70.

DOI : 10.1038/s41598-017-12135-7

ISSN: 2045-2322
Cilt: 7
Sayı: 1
Sayfa: 1 - 10

Sınıflandırma :

Biyotıp %100

Hematoloji %100

18

ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation.

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

PLoS ONE

Yazar(lar) :

Eva Calpe , Noelia Purroy , Cecilia Carpio , Pau Abrisqueta , Júlia Carabia , Carles Palacio , Josep Castellví , Marta Crespo , Francesc Bosch

Yıl :

2013

Marta Crespo

Özet Ek Bilgiler

Kaydet

ZAP-70 in chronic lymphocytic leukemia (CLL) is associated with enhanced response to microenvironmental stimuli. We analyzed the functional consequences of ZAP-70 ectopic expression in malignant B-cells in a xenograft mouse model of disseminated B-cell leukemia. Mice injected with B-cells expressing ZAP-70 showed a prominently higher infiltration of the bone marrow. In vitro analysis of the response of malignant B-cells to CXCL12, the main attracting chemokine regulating trafficking of lymphocytes to the bone marrow, or to bone marrow stromal cells, revealed that ZAP-70 induces an increased response in terms of signaling and migration. These effects are probably mediated by direct participation of ZAP-70 in CXCL12-CXCR4 signaling since CXCR4 stimulation led to activation of ZAP-70 and downstream signaling pathways, such as MAPK and Akt, whereas ZAP-70 did not alter the expression of the CXCR4 receptor. In addition, subclones of primary CLL cells with high expression of ZAP-70 also showed increased migrative capacity toward CXCL12. Neutralization of CXCR4 with a monoclonal antibody resulted in impaired in vitro responses to CXCL12 and bone marrow stromal cells. We conclude that ZAP-70 enhances the migration of malignant B-cells into the supportive microenvironment found in the bone marrow mainly by enhancing signaling and migration after CXCR4 stimulation.

DOI : 10.1371/journal.pone.0081221

ISSN: 1932-6203
Cilt: 8
Sayı: 12
Sayfa: e81221

Sınıflandırma :

Biyotıp %100

Hematoloji %97

19

Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Scientific Reports

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Armando Coca , Carlos Arias-Cabrales , Ana Lucía Valencia , Carla Burballa , Juan Bustamante-Munguira , Dolores Redondo-Pachón , Isabel Acosta-Ochoa , Marta Crespo , Jesús Bustamante , Alicia Mendiluce , Julio Pascual , María José Pérez-SaézArmando Coca , Carlos Arias-Cabrales , Ana Lucía Valencia , Carla Burballa , Juan Bustamante-Munguira , Dolores Redondo-Pachón , Isabel Acosta-Ochoa , Marta Crespo , Jesús Bustamante , Alicia Mendiluce , Julio Pascual , María José Pérez-Saéz

Yıl :

2020

Marta Crespo Marta Crespo

Özet Ek Bilgiler

Kaydet

Abstract\n Pre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organ discard rates. Since most of these scores come from the US, direct application in non-US populations is not advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival (EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed to examine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohort-based study of deceased-donor kidney transplants carried out in two different Spanish hospitals. Unadjusted and adjusted Cox models were applied for patient survival. Predictive models were compared using Harrell’s C statistics. SBE, EPTS and KDPI were independently associated with patient survival (p ≤ 0.01 in all models). Model discrimination measured with Harrell’s C statistics ranged from 0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration and discrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly among high EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating post-transplant survival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing.

DOI : 10.1038/s41598-020-74295-3

ISSN: 2045-2322
Sayı: 1
Cilt: 10

20

Manejo de la epidemia por coronavirus SARS-CoV-2 (COVID-19) en unidades de hemodiálisis

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Nefrología

Yazar(lar) :

María Dolores Arenas , Judit Villar , Cristina González , Higinio Cao , Silvia Collado , Marta Crespo , Juan Pablo Horcajada , Julio Pascual

Yıl :

2020

Marta Crespo

Özet Ek Bilgiler

Kaydet

Resumen: La epidemia de SARS-CoV-2 representa un riesgo especial para los pacientes renales por su condición de personas con comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas. La información específica en el momento actual al respecto es muy limitada. El presente manuscrito recoge una propuesta de actuación para prevenir la infección en los Servicios de Nefrología, y en particular en las unidades de hemodiálisis, con el objetivo de identificar precozmente a los pacientes que cumplan con la definición de caso sospechoso de infección por el SARS-CoV-2 y proponer circuitos y mecanismos para administrarles el tratamiento con hemodiálisis. Son recomendaciones en continua revisión y podrán ser modificadas si la situación epidemiológica y las opciones diagnóstico-terapéuticas así lo requieren. Abstract: The current outbreak of SARS-CoV-2 represents a special risk for renal patients due to their comorbidities and advanced age. The usual performance of hemodialysis treatments in collective rooms increases the risk. The specific information at this time in this regard is very limited. This manuscript includes a proposal for action to prevent infection in the Nephrology Services, and in particular in Hemodialysis Units, with the objective of early identification of patients who meet the definition of a suspected case of infection by SARS-CoV-2 and propose circuits and mechanisms to carry out hemodialysis treatments. They are recommendations in continuous review and can be modified if the epidemiological situation, the diagnostic and therapeutic options so require.

Anahtar Kelimeler : Hemodialysis, SARS-CoV-2, COVID-19, Coronavirus

ISSN: 0211-6995
Cilt: 40
Sayı: 3
Sayfa: 258 - 264

21

Analysis of the IGHV region in Burkitt's lymphomas supports a germinal center origin and a role for superantigens in lymphomagenesis

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Leukemia Research

Yayıncı:

Elsevier

Yazar(lar) :

Maria Joao Baptista , Eva Calpe , Eva Fernandez , Lluis Colomo , Teresa Marta Cardesa-Salzmann , Pau Abrisqueta , Francesc Bosch , Marta Crespo

Yıl :

2014

Marta Crespo

Özet Ek Bilgiler

Kaydet

The analysis of immunoglobulin heavy chain variable (IGHV) region may disclose the influence of antigens in Burkitt's lymphomas (BL). IGHV sequences from 38 patients and 35 cell lines were analyzed. IGHV3 subset genes were the most used and IGHV4-34 gene was overrepresented. IGHV genes were mutated in 98.6% of the cases, 36% acquired potential glycosylation sites, and in 52% somatic-hypermutation-process was ongoing. Binding motifs for superantigens like Staphylococcal protein A and carbohydrate I/i were preserved in 89% of the cases. IGHV analysis of BL cells supports a germinal center origin and points toward a role for superantigens in lymphomagenesis.

DOI : 10.1016/j.leukres.2014.01.001

Anahtar Kelimeler : BL, IGHV, SHM, Superantigens, Intraclonal diversity, Glycosylation

ISSN: 0145-2126
Sayı: 4
Cilt: 38
Sayfa: 509-515

Sınıflandırma :

Biyotıp %65

Hematoloji %100

Tıp ve Halk Sağlığı %34

Kanser Araştırmaları %49

Anatomi %33

22

Protección de los profesionales sanitarios en nefrología ante la pandemia por COVID-19

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Nefrología

Yazar(lar) :

María Dolores Arenas , Judit Villar , Cristina González , Higinio Cao , Silvia Collado , Francesc Barbosa , Marta Crespo , Juan Pablo Horcajada , Julio Pascual

Yıl :

2020

Marta Crespo

Özet Ek Bilgiler

Kaydet

Resumen: La epidemia de COVID-19 representa un riesgo especial para los pacientes renales por sus comorbilidades y edad avanzada, y por la realización del tratamiento de hemodiálisis en salas colectivas, pero también supone un riesgo para los profesionales responsables de su atención. El presente manuscrito recoge una propuesta de actuación para prevenir la infección entre los profesionales en los Servicios de Nefrología. Abstract: The COVID-19 epidemic represents a special risk for kidney patients due to their comorbidities and advanced age, and the need for hemodialysis treatment in group rooms. It also represents a risk for professionals responsible for their attention. This manuscript contains a proposal for action to prevent infection of professionals in the Nephrology Services, one of the most valuable assets at the present time.

Anahtar Kelimeler : Nephrology, SARS-CoV-2, COVID-19, Coronavirus, Health-care workers

ISSN: 0211-6995
Cilt: 40
Sayı: 4
Sayfa: 395 - 402

23

Lymphocyte-depleting induction and steroid minimization after kidney transplantation: A review

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Nefrología (English Edition)

Yazar(lar) :

Maarten Naesens , Stefan Berger , Luigi Biancone , Marta Crespo , Arjang Djamali , Alexandre Hertig , Robert Öllinger , José Portolés , Andreas Zuckermann , Julio Pascual

Yıl :

2016

Marta Crespo

Yayıncı Web Siteleri

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Steroid minimization after kidney transplantation has become more widely practiced as transplant clinicians seek the potential benefits such as reduced cardiovascular risk factors, improved growth in pediatric patients, and improved compliance with the immunosuppression regimen. Steroid avoidance (i.e. no steroids after the first week) is generally favored compared to later withdrawal. Induction therapy is routine in this setting, frequently rabbit antithymocyte globulin (rATG, Thymoglobulin®) or off-license use of alemtuzumab. Direct comparisons of steroid minimization regimens versus standard steroid regimens are rare. However, the available data show that the risk of acute rejection is low when rATG or alemtuzumab induction is given to support steroid-avoidance regimens after kidney transplantation. Steroid avoidance may be inadvisable in patients at high immunological risk or at risk of recurrent glomerular disease. Steroid withdrawal after day 8 may be possible without additional risk of rejection in patients given rATG induction, but while encouraging, the data are too sparse for firm conclusions. In summary, steroid avoidance may be beneficial for patients after renal transplantation, with the potential to avoid or reduce steroid-related comorbidities. Whilst depleting induction therapy could be the treatment of choice, results of prospective randomized, controlled studies are eagerly awaited.

Kaynak 1:

https://doi.org/10.1016/j.nefroe.2016.09.001 arayıcılığı görüntüle.
Kaynak 2:

https://doi.org/10.1016/j.nefro.2016.03.019 arayıcılığı görüntüle.

DOI : 10.1016/j.nefroe.2016.09.001

Anahtar Kelimeler : Induction, Depletion, Steroid sparing, Steroid avoidance, Kidney transplantation, Rabbit antithymocyte globulin, Thymoglobulin, Alemtuzumab

ISSN: 2013-2514
Cilt: 36
Sayı: 5
Sayfa: 469 - 480

Sınıflandırma :

Nefroloji %100

24

Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Transplant Immunology

Yayıncı:

Elsevier

Yazar(lar) :

Dolores Redondo-Pachón , Julio Pascual , María J. Pérez-Sáez , Carmen García , Juan José Hernández , Javier Gimeno , Marisa Mir , Marta Crespo

Yıl :

2016

Marta Crespo

Özet Ek Bilgiler

Kaydet

The influence of antibodies against HLA-DP antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex® the prevalence of pre- and posttransplant DP antibodies in 440 KT patients and their impact on graft survival. For 291 patients with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p = 0.01). DP antibodies did not influence graft survival. Of 346 patients monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in patients with class-II DSA (p = 0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly.

DOI : 10.1016/j.trim.2015.11.002

Anahtar Kelimeler : Renal transplant, HLA-DP antibodies, Graft survival

ISSN: 0966-3274
Cilt: 34
Sayfa: 1-7

Sınıflandırma :

Tıp ve Halk Sağlığı %55

Nakil Cerrahisi %99

Biyotıp %45

Hematoloji %36

25

Increased hip fracture and mortality in chronic kidney disease individuals: The importance of competing risks

Dergi Makalesi

Kaynak :

Science Direct

Yazar(lar) :

María José Pérez-Sáez , Daniel Prieto-Alhambra , Clara Barrios , Marta Crespo , Dolores Redondo , Xavier Nogués , Adolfo Díez-Pérez , Julio Pascual

Yıl :

2015

Marta Crespo

Özet Ek Bilgiler

Kaydet

Background Many studies have shown a correlation between chronic kidney disease (CKD) and fracture. However, increased mortality in CKD patients is a competing risk scenario not accounted for in previous studies. Our aim was to investigate the true impact of CKD on hip fracture after accounting for a competing risk with death. Methods We conducted a population-based cohort study to determine the impact of CKD on hip fractures in individuals aged ≥ 50 years old registered in the SIDIAPQ database (representative of 1.9 million people in Catalonia, Spain). Cox regression was used to estimate hazard ratio (HR) for death and hip fracture according to CKD status. A competing risk (Fine and Gray) model was fitted to estimate sub-HR for hip fracture in CKD or CKD-free patients accounting for differential mortality. Results A total of 873,073 (32,934 (3.8%) CKD) patients were observed for 3 years. During follow-up, 4,823 (14.6%) CKD and 36,328 (4.3%) CKD-free participants died (HR, 1.83 [95% CI, 1.78–1.89]), whilst 522 (1.59%) and 6,292 (0.75%) sustained hip fractures, respectively. Adjusted Cox models showed a significantly increased risk of hip fractures for the CKD group (HR, 1.16 [1.06–1.27]), but this association was attenuated in competing risk models accounting for mortality (SHR, 1.14 [1.03–1.27]). Conclusions Both death and hip fracture rates are increased (by 83% and 16%, respectively) in CKD patients. However, the association between CKD and hip fractures is attenuated when an excess of mortality is taken into account. A competing risk with death must be considered in future analyses of association between CKD and any health outcomes.

DOI : 10.1016/j.bone.2014.12.020

Anahtar Kelimeler : Bone disease, Chronic kidney disease, Epidemiology, Fractures, Mortality

ISSN: 8756-3282
Cilt: 73
Sayfa: 154-159

Sınıflandırma :

Geriatri ve Gerontoloji %65

26

Impact of intra-abdominal pressure on early kidney transplant outcomes

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Scientific Reports

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Armando Coca , Carlos Arias-Cabrales , María José Pérez-Sáez , Verónica Fidalgo , Pablo González , Isabel Acosta-Ochoa , Arturo Lorenzo , María Jesús Rollán , Alicia Mendiluce , Marta Crespo , Julio Pascual , Juan Bustamante-Munguira

Yıl :

2022

Marta Crespo

Özet Ek Bilgiler

Kaydet

AbstractIncreased intra-abdominal pressure (IAP) is common among post-surgical patients and may cause organ dysfunction. However, its impact after kidney transplantation on early postoperative complications and graft recovery remains unclear. We designed a prospective, observational cohort study to describe the prevalence and determinants of IAP, as well as its effect on delayed graft function, postoperative complications, and graft recovery. IAP was measured in 205 kidney transplant recipients every 8 h during the first 72 h after surgery using the urinary bladder technique. Intra-abdominal hypertension was defined as IAP ≥ 12 mmHg. Patients were followed for 6 months or until graft failure/death. Mean IAP was 12 ± 3.3 mmHg within the first 24 h. 78% of subjects presented with intra-abdominal hypertension during the first 72 h. Increased IAP was associated with higher renal resistive index [r = 0.213; P = 0.003] and lower urine output [r = − 0.237; P < 0.001]. 72 h mean IAP was an independent risk factor for delayed graft function [OR: 1.31; 95% CI: 1.13–1.51], postoperative complications [OR: 1.17; 95% CI: 1.03–1.33], and absence of graft function recovery [HR for graft function recovery: 0.94; 95% CI: 0.88–0.99]. Increased IAP was highly prevalent after transplantation and was independently associated with delayed graft function, postoperative complications, and absence of graft function recovery. Routine IAP monitoring should be considered post-transplantation to facilitate early recognition of relevant complications.

DOI : 10.1038/s41598-022-06268-7

ISSN: 2045-2322
Sayı: 1
Cilt: 12

27

Usefulness of the KDPI in Spain: A comparison with donor age and definition of standard/expanded criteria donor.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Nefrologia

Yazar(lar) :

Carlos Arias-Cabrales , María José Pérez-Sáez , Dolores Redondo-Pachón , Anna Buxeda , Carla Burballa , Sheila Bermejo , Adriana Sierra , Marisa Mir , Andrea Burón , Ana Zapatero , Marta Crespo , Julio Pascual

Yıl :

2018

Marta Crespo

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Kidney donor shortage requires expanding donor selection criteria, as well as use of objective tools to minimize the percentage of discarded organs. Some donor pre-transplant variables such as age, standard/expanded criteria donor (SCD/ECD) definition and calculation of the Kidney Donor Profile Index (KDPI), have demonstrated correlations with patient and graft outcomes. We aimed to establish the accuracy of the three models to determine the prognostic value of kidney transplantation (KT) major outcomes.

DOI : 10.1016/j.nefro.2018.03.003

Anahtar Kelimeler : Donante con criterios ampliados, Donor age, Edad del donante, Expanded criteria donor, Kidney Donor Profile Index, Kidney transplant, Trasplante renal

Sınıflandırma :