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Applying a hierarchical clustering on principal components approach to identify different patterns of the SARS-CoV-2 epidemic across Italian regions
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Scientific Reports
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Guido Basile , Antonella AgodiAndrea Maugeri , Martina Barchitta , Guido Basile , Antonella Agodi
Yıl :
2021
Martina Barchitta Martina Barchitta
Yayıncı Web Sitesi
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Kaydet
AbstractItaly has experienced the epidemic of Severe Acute Respiratory Syndrome Coronavirus 2, which spread at different times and with different intensities throughout its territory. We aimed to identify clusters with similar epidemic patterns across Italian regions. To do that, we defined a set of regional indicators reflecting different domains and employed a hierarchical clustering on principal component approach to obtain an optimal cluster solution. As of 24 April 2020, Lombardy was the worst hit Italian region and entirely separated from all the others. Sensitivity analysis—by excluding data from Lombardy—partitioned the remaining regions into four clusters. Although cluster 1 (i.e. Veneto) and 2 (i.e. Piedmont and Emilia-Romagna) included the most hit regions beyond Lombardy, this partition reflected differences in the efficacy of restrictions and testing strategies. Cluster 3 was heterogeneous and comprised regions where the epidemic started later and/or where it spread with the lowest intensity. Regions within cluster 4 were those where the epidemic started slightly after Veneto, Emilia-Romagna and Piedmont, favoring timely adoption of control measures. Our findings provide policymakers with a snapshot of the epidemic in Italy, which might help guiding the adoption of countermeasures in accordance with the situation at regional level.
DOI : 10.1038/s41598-021-86703-3
ISSN: 2045-2322
Sayı: 1
Cilt: 11
2
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
MDPI
Dergi:
Medicina
Yazar(lar) :
Andrea Maugeri , Martina Barchitta
Yıl :
2020
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
Over the past decades, DNA methylation has been proposed as a molecular mechanism underlying the positive or negative effects of diet on human health. Despite the number of studies on this topic is rapidly increasing, the relationship between dietary factors, changes in DNA methylation and health outcomes remains unclear. In this review, we summarize the literature from observational studies (cross-sectional, retrospective, or prospective) which examined the association of dietary factors (nutrients, foods, and dietary patterns) with DNA methylation markers among diseased or healthy people during the lifetime. Next, we discuss the methodological pitfalls by examining strengths and limitations of published studies. Finally, we close with a discussion on future challenges of this field of research, raising the need for large-size prospective studies evaluating the association between diet and DNA methylation in health and diseases for appropriate public health strategies.
DOI : 10.3390/medicina56080374
Anahtar Kelimeler : nutritional epidemiology, epigenetics, folate, dietary patterns
Cilt: 56
Sayı: 374
Sayfa: 374
Sınıflandırma :
3
Association between Vascular Endothelial Growth Factor Polymorphisms and Age-Related Macular Degeneration: An Updated Meta-Analysis
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Disease Markers
Yazar(lar) :
Martina Barchitta , Andrea Maugeri
Yıl :
2016
Martina Barchitta
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet
Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibility. The aim of the present study is to carry out a systematic review and an updated meta-analysis in order to summarize the current published studies and to evaluate the associations between four common vascular endothelial growth factor (VEGF) polymorphisms (rs833061, rs1413711, rs3025039, and rs2010963) and AMD risk, also stratifying for AMD subtypes and ethnicity. A systematic literature search in the Medline database, using PubMed, was carried out for epidemiological studies, published before June 2016. Associations of VEGF polymorphisms with AMD were estimated by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) based on different models. Twelve articles were included in the analysis. The present meta-analysis constitutes a useful guide for readers to study AMD and adds new evidence to the growing literature on the role of VEGF polymorphisms in the risk of AMD. Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
DOI : 10.1155/2016/8486406
Cilt: 2016
Sınıflandırma :
4
A Systematic Review of Ecological Momentary Assessment of Diet: Implications and Perspectives for Nutritional Epidemiology
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
MDPI
Dergi:
Nutrients
Yazar(lar) :
Andrea Maugeri , Martina Barchitta
Yıl :
2019
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
The ecological momentary assessment (EMA) of eating behaviors represents an innovative, detailed and valid approach to capture the complexity of food intake and to overcome limitations of traditional dietary assessment methods. Moreover, EMA studies might generate a large variety of data (e.g., dietary, behavioral, physical, sociopsychological, and contextual information), thereby enabling to examine concurrent exposures and events. Due to the increasing number of studies in this field of research, here we systematically reviewed EMA methods for the assessment of dietary intake in epidemiological studies, and discussed implications and perspectives for future research. Our study summarized several protocols and platforms that may be applied to assess diet in terms of eating frequency, choices, and habits. Nearly 38% of studies used an event-contingent strategy by asking participants to report foods and beverages consumed in real-time at each eating occasion. Instead, approximately 55% of studies used a signal-contingent prompting approach that notified the participants to record their dietary consumption. The remaining studies used a combination of event- and signal-contingent protocols to compare their accuracy or to improve the assessment of dietary data. Although both approaches might improve the accuracy and ecological validity of dietary assessment—also reducing the burden for participants—some limitations should nevertheless be considered. Despite these limitations, our systematic review pointed out that EMA can be applied in various fields of nutritional epidemiology, from the identification of determinants of dietary habits in healthy people to the management of patients with eating or metabolic disorders. However, more efforts should be encouraged to improve the validity and the reliability of EMA and to provide further technological innovations for public health research and interventions.
DOI : 10.3390/nu11112696
Anahtar Kelimeler : dietary assessment, epidemiology, foods, nutrients, obesity, eating behaviors
ISSN: 2072-6643
Cilt: 11
Sayı: 11
Sayfa: 2696
Sınıflandırma :
5
A Clustering Approach to Classify Italian Regions and Provinces Based on Prevalence and Trend of SARS-CoV-2 Cases
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
MDPI
Dergi:
International Journal of Environmental Research and Public Health
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Antonella Agodi
Yıl :
2020
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
While several efforts have been made to control the epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Italy, differences between and within regions have made it difficult to plan the phase two management after the national lockdown. Here, we propose a simple and immediate clustering approach to categorize Italian regions working on the prevalence and trend of SARS-CoV-2 positive cases prior to the start of phase two on 4 May 2020. Applying both hierarchical and k-means clustering, we identified three regional groups: regions in cluster 1 exhibited higher prevalence and the highest trend of SARS-CoV-2 positive cases; those classified into cluster 2 constituted an intermediate group; those in cluster 3 were regions with a lower prevalence and the lowest trend of SARS-CoV-2 positive cases. At the provincial level, we used a similar approach but working on the prevalence and trend of the total SARS-CoV-2 cases. Notably, provinces in cluster 1 exhibited the highest prevalence and trend of SARS-CoV-2 cases. Provinces in clusters 2 and 3, instead, showed a median prevalence of approximately 11 cases per 10,000 residents. However, provinces in cluster 3 were those with the lowest trend of cases. K-means clustering yielded to an alternative cluster solution in terms of the prevalence and trend of SARS-CoV-2 cases. Our study described a simple and immediate approach to monitor the SARS-CoV-2 epidemic at the regional and provincial level. These findings, at present, offered a snapshot of the epidemic, which could be helpful to outline the hierarchy of needs at the subnational level. However, the integration of our approach with further indicators and characteristics could improve our findings, also allowing the application to different contexts and with additional aims.
DOI : 10.3390/ijerph17155286
Anahtar Kelimeler : COVID-19, clustering, positive cases, epidemiology
Cilt: 17
Sayı: 5286
Sayfa: 5286
Sınıflandırma :
6
Gene–nutrient interaction
Kitap Bölümü

Kitap Bölümü
Kaynak :
Science Direct
Dergi:
Molecular Nutrition: Mother and Infant
Yayıncı:
Elsevier
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Antonella Agodi
Yıl :
2021
Martina Barchitta
Yayıncı Web Sitesi
Tam Metin
Kaydet
DOI : 10.1016/b978-0-12-813862-5.00012-8
Sayfa: 299-315
7
The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
Wiley Online Library
Kaynak 2:
PubMed
Dergi:
Acta Ophthalmologica
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Antonella Agodi
Konu :
Ophthalmology, General Medicine
Yıl :
2018
Martina Barchitta
Tam Metin
Kaydet
DOI : 10.1111/aos.13849
ISSN: 1755-375X
Sayı: 1
Cilt: 97
Sayfa: e8-e21
8
Modeling the Novel Coronavirus (SARS-CoV-2) Outbreak in Sicily, Italy
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
MDPI
Dergi:
International Journal of Environmental Research and Public Health
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Sebastiano Battiato , Antonella Agodi
Yıl :
2020
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
Italy was the first country in Europe which imposed control measures of travel restrictions, quarantine and contact precautions to tackle the epidemic spread of the novel coronavirus (SARS-CoV-2) in all its regions. While such efforts are still ongoing, uncertainties regarding SARS-CoV-2 transmissibility and ascertainment of cases make it difficult to evaluate the effectiveness of restrictions. Here, we employed a Susceptible-Exposed-Infectious-Recovered-Dead (SEIRD) model to assess SARS-CoV-2 transmission dynamics, working on the number of reported patients in intensive care unit (ICU) and deaths in Sicily (Italy), from 24 February to 13 April. Overall, we obtained a good fit between estimated and reported data, with a fraction of unreported SARS-CoV-2 cases (18.4%; 95%CI = 0–34.0%) before 10 March lockdown. Interestingly, we estimated that transmission rate in the community was reduced by 32% (95%CI = 23–42%) after the first set of restrictions, and by 80% (95%CI = 70–89%) after those adopted on 23 March. Thus, our estimates delineated the characteristics of SARS-CoV2 epidemic before restrictions taking into account unreported data. Moreover, our findings suggested that transmission rates were reduced after the adoption of control measures. However, we cannot evaluate whether part of this reduction might be attributable to other unmeasured factors, and hence further research and more accurate data are needed to understand the extent to which restrictions contributed to the epidemic control.
DOI : 10.3390/ijerph17144964
Anahtar Kelimeler : novel coronavirus, COVID-19, epidemic model, epidemiology
Cilt: 17
Sayı: 4964
Sayfa: 4964
Sınıflandırma :
9
Detection of genetically modified DNA sequences in milk from The Italian market
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
International Journal of Hygiene and Environmental Health
Yayıncı:
Elsevier
Yazar(lar) :
Antonella Agodi , Martina Barchitta , Agata Grillo , Salvatore Sciacca
Yıl :
2006
Martina Barchitta
Yayıncı Web Sitesi
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Kaydet
DOI : 10.1016/j.ijheh.2005.08.005
ISSN: 1438-4639
Sayı: 1
Cilt: 209
Sayfa: 81-88
Sınıflandırma :
10
Effects of Vitamin D Supplementation During Pregnancy on Birth Size: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Nutrients
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Isabella Blanco , Antonella Agodi
Yıl :
2019
Martina Barchitta
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet
During pregnancy, vitamin D supplementation may be a feasible strategy to help prevent low birthweight (LBW) and small for gestational age (SGA) births. However, evidence from randomized controlled trials (RCTs) is inconclusive, probably due to heterogeneity in study design and type of intervention. A systematic literature search in the PubMed-Medline, EMBASE, and Cochrane Central Register of Controlled Trials databases was carried out to evaluate the effects of oral vitamin D supplementation during pregnancy on birthweight, birth length, head circumference, LBW, and SGA. The fixed-effects or random-effects models were used to calculate mean difference (MD), risk ratio (RR), and 95% Confidence Interval (CI). On a total of 13 RCTs, maternal vitamin D supplementation had a positive effect on birthweight (12 RCTs; MD = 103.17 g, 95% CI 62.29⁻144.04 g), length (6 RCTs; MD = 0.22 cm, 95% CI 0.11⁻0.33 cm), and head circumference (6 RCTs; MD:0.19 cm, 95% CI 0.13⁻0.24 cm). In line with these findings, we also demonstrated that maternal vitamin D supplementation reduced the risk of LBW (3 RCTs; RR = 0.40, 95% CI 0.22⁻0.74) and SGA (5 RCTS; RR = 0.69, 95% CI 0.51⁻0.92). The present systematic review and meta-analysis confirmed the well-established effect of maternal vitamin D supplementation on birth size. However, further research is required to better define risks and benefits associated with such interventions and the potential implications for public health.
DOI : 10.3390/nu11020442
Anahtar Kelimeler : nutrition, vitamin D, birthweight, birth length, head circumference, gestational age, pregnancy outcomes
ISSN: 2072-6643
Cilt: 11
Sayı: 2
Sayfa: 442
Sınıflandırma :
11
Estimation of Unreported Novel Coronavirus (SARS-CoV-2) Infections from Reported Deaths: A Susceptible–Exposed–Infectious–Recovered–Dead Model
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Journal of Clinical Medicine
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Sebastiano Battiato , Antonella Agodi
Yıl :
2020
Martina Barchitta
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet
In the midst of the novel coronavirus (SARS-CoV-2) epidemic, examining reported case data could lead to biased speculations and conclusions. Indeed, estimation of unreported infections is crucial for a better understanding of the current emergency in China and in other countries. In this study, we aimed to estimate the unreported number of infections in China prior to the 23 January 2020 restrictions. To do this, we developed a Susceptible–Exposed–Infectious–Recovered–Dead (SEIRD) model that estimated unreported infections from the reported number of deaths. Our approach relied on the fact that observed deaths were less likely to be affected by ascertainment biases than reported infections. Interestingly, we estimated that the basic reproductive number (R0) was 2.43 (95%CI = 2.42–2.44) at the beginning of the epidemic and that 92.9% (95%CI = 92.5%–93.1%) of total cases were not reported. Similarly, the proportion of unreported new infections by day ranged from 52.1% to 100%, with a total of 91.8% (95%CI = 91.6%–92.1%) of infections going unreported. Agreement between our estimates and those from previous studies proves that our approach is reliable for estimating the prevalence and incidence of undocumented SARS-CoV-2 infections. Once it has been tested on Chinese data, our model could be applied to other countries with different surveillance and testing policies.
DOI : 10.3390/jcm9051350
Anahtar Kelimeler : novel coronavirus, COVID-19, epidemic model, epidemiology
ISSN: 2077-0383
Cilt: 9
Sayı: 1350
Sayfa: 1350
Sınıflandırma :
12
Epidemiology and Control of Urinary Tract Infections in Intensive Care Patients
e-Kitap

e-Kitap
Open Access
Kaynak :
IntechOpen
Yazar(lar) :
Antonella Agodi , Martina Barchitta
Yıl :
2011
Martina Barchitta
Yayıncı Web Sitesi
Tam Metin
Kaydet
DOI : 10.5772/23113
Sınıflandırma :
13
Complement System and Age-Related Macular Degeneration: Implications of Gene-Environment Interaction for Preventive and Personalized Medicine.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
PubMed
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Biomed Res Int
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Maria Grazia Mazzone , Francesco Giuliano , Antonella Agodi
Yıl :
2018
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
Age-related macular degeneration (AMD) is the most common cause of visual loss in developed countries, with a significant economic and social burden on public health. Although genome-wide and gene-candidate studies have been enabled to identify genetic variants in the complement system associated with AMD pathogenesis, the effect of gene-environment interaction is still under debate. In this review we provide an overview of the role of complement system and its genetic variants in AMD, summarizing the consequences of the interaction between genetic and environmental risk factors on AMD onset, progression, and therapeutic response. Finally, we discuss the perspectives of current evidence in the field of genomics driven personalized medicine and public health.
DOI : 10.1155/2018/7532507
Sınıflandırma :
14
DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak 1:
PLOS - Public Library of Science
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Public Library of Science
Yazar(lar) :
Manlio Vinciguerra , Andrea Maugeri , Annalisa Quattrocchi , Martina Barchitta , Antonella Agodi
Yıl :
2015
Martina Barchitta
Tam Metin
Kaydet
Objective The Death-Associated Protein Kinase 1 (DAPK1) gene has been frequently investigated in cervical cancer (CC). The aim of the present study was to carry out a systematic review and a meta-analysis in order to evaluate DAPK1 promoter methylation as an epigenetic marker for CC risk. Methods A systematic literature search was carried out. The Cochrane software package Review Manager 5.2 was used. The fixed-effects or random-effects models, according to heterogeneity across studies, were used to calculate odds ratios (ORs) and 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by histological type, assays used to evaluate DAPK1 promoter methylation, and control sample source. Results A total of 20 papers, published between 2001 and 2014, on 1929 samples, were included in the meta-analysis. DAPK1 promoter methylation was associated with an increased CC risk based on the random effects model (OR: 21.20; 95%CI = 11.14–40.35). Omitting the most heterogeneous study, the between study heterogeneity decreased and the association increased (OR: 24.13; 95% CI = 15.83–36.78). The association was also confirmed in all the subgroups analyses. Conclusions A significant strong association between DAPK1 promoter methylation and CC was shown and confirmed independently by histological tumor type, method used to evaluate methylation and source of control samples. Methylation markers may have value in early detection of CC precursor lesions, provide added reassurances of safety for women who are candidates for less frequent screens, and predict outcomes of women infected with human papilloma virus.
DOI : 10.1371/journal.pone.0135078
Anahtar Kelimeler : Methylation, DNA methylation, Meta-analysis, Biopsy, Histology, Squamous cell carcinomas, Lesions, Systematic reviews
Sınıflandırma :
15
The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
Hindawi Limited
Dergi:
International Journal of Genomics
Yazar(lar) :
Martina Barchitta , Andrea Maugeri , Annalisa Quattrocchi , Ottavia Agrifoglio , Antonella Agodi
Yıl :
2017
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
Several studies showed that altered expression of the miRNA-ome in maternal circulation or in placental tissue may reflect not only gestational disorders, such as preeclampsia, spontaneous abortion, preterm birth, low birth weight, or macrosomia, but also prenatal exposure to environmental pollutants. Generally, the relationships between environmental exposure, changes in miRNA expression, and gestational disorders are explored separately, producing conflicting findings. However, validation of tissue-accessible biomarkers for the monitoring of adverse pregnancy outcomes needs a systematic methodological approach that takes also into account early-life environmental exposure. To achieve this goal, exposure to xenochemicals, endogenous agents, and diet should be assessed. This study has the aim to provide a comprehensive review on the role of miRNAs as potential biomarkers for adverse pregnancy outcomes and prenatal environmental exposure.
DOI : 10.1155/2017/8067972
Cilt: 2017
Sınıflandırma :
16
Tumor Necrosis Factor-Alpha −308 G>A Polymorphism, Adherence to Mediterranean Diet, and Risk of Overweight/Obesity in Young Women
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
BioMed Research International
Yazar(lar) :
Martina Barchitta , Annalisa Quattrocchi , Veronica Adornetto , Anna Elisa Marchese , Antonella Agodi
Yıl :
2014
Martina Barchitta
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet
The present study was conducted in order to (i) characterize the adherence to the Mediterranean diet (MD) pattern and fatty acids (FAs) intakes and (ii) explore interactions between TNFA −308 G>A polymorphism and adherence to MD and FAs intakes, respectively, on overweight/obesity risk. From 2010 to 2013, 380 healthy women were enrolled, and MD score (MDS) and FAs intakes were evaluated by a Food Frequencies Questionnaire in relation to nutritional status. TNFA −308 G/A polymorphism was characterized using PCR-RFLP. A total of 32.6% of women were overweight or obese. Lower mean MDS values were more observed in the younger age group than in the older age group (3.60 versus 4.45). The risk of being overweight/obese was 3.5-fold increased due to poor adherence to MD and was about twofold increased in less educated women. Furthermore, younger age was associated with poor adherence to MD. No evidence for an independent effect of the polymorphism on overweight/obesity risk was found. There was no evidence of biological interaction from the gene-diet interaction analyses. Young women, less educated and with poor adherence to MD, are a target group for the nutritional interventions that aimed to control the obesity risk, thus improving the adherence to MD and particularly the intake of unsaturated FAs.
DOI : 10.1155/2014/742620
Cilt: 2014
Sınıflandırma :
17
LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: a systematic review and meta-analysis.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
PLoS ONE
Yazar(lar) :
Martina Barchitta , Annalisa Quattrocchi , Andrea Maugeri , Manlio Vinciguerra , Antonella Agodi
Yıl :
2014
Martina Barchitta
Yayıncı Web Sitesi
Tam Metin
Kaydet
A systematic review and a meta-analysis were carried out in order to summarize the current published studies and to evaluate LINE-1 hypomethylation in blood and other tissues as an epigenetic marker for cancer risk.A systematic literature search in the Medline database, using PubMed, was conducted for epidemiological studies, published before March 2014. The random-effects model was used to estimate weighted mean differences (MDs) with 95% Confidence Intervals (CIs). Furthermore, subgroup analyses were conducted by sample type (tissue or blood samples), cancer types, and by assays used to measure global DNA methylation levels. The Cochrane software package Review Manager 5.2 was used.A total of 19 unique articles on 6107 samples (2554 from cancer patients and 3553 control samples) were included in the meta-analysis. LINE-1 methylation levels were significantly lower in cancer patients than in controls (MD: -6.40, 95% CI: -7.71, -5.09; p<0.001). The significant difference in methylation levels was confirmed in tissue samples (MD -7.55; 95% CI: -9.14, -65.95; p<0.001), but not in blood samples (MD: -0.26, 95% CI: -0.69, 0.17; p = 0.23). LINE-1 methylation levels were significantly lower in colorectal and gastric cancer patients than in controls (MD: -8.33; 95% CI: -10.56, -6.10; p<0.001 and MD: -5.75; 95% CI: -7.75, -3.74; p<0.001) whereas, no significant difference was observed for hepatocellular cancer.The present meta-analysis adds new evidence to the growing literature on the role of LINE-1 hypomethylation in human cancer and demonstrates that LINE-1 methylation levels were significantly lower in cancer patients than in control samples, especially in certain cancer types. This result was confirmed in tissue samples, both fresh/frozen or FFPE specimens, but not in blood. Further studies are needed to better clarify the role of LINE-1 methylation in specific subgroups, considering both cancer and sample type, and the methods of measurement.
DOI : 10.1371/journal.pone.0109478
ISSN: 1932-6203
Cilt: 9
Sayı: 10
Sayfa: e109478
18
The Association of Dietary Patterns with High-Risk Human Papillomavirus Infection and Cervical Cancer: A Cross-Sectional Study in Italy.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
PubMed
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Nutrients
Yazar(lar) :
Martina Barchitta , Andrea Maugeri , Annalisa Quattrocchi , Ottavia Agrifoglio , Aurora Scalisi , Antonella Agodi
Konu :
Adult, Case-Control Studies, Cervical Intraepithelial Neoplasia, Chi-Square Distribution, Cross-Sectional Studies, Diet, Mediterranean, Eating, Feeding Behavior, Female, Healthy Diet, Humans, Italy, Linear Models, Logistic Models, Middle Aged, Neoplasm Grading, Odds Ratio, Papillomavirus Infections, Principal Component Analysis, Protective Factors, Risk Assessment, Risk Factors, Risk Reduction Behavior, Surveys and Questionnaires, Uterine Cervical Neoplasms
Yıl :
2018
Martina Barchitta
Piri Tam Metin Bulucu
Kaydet
Specific foods and nutrients help prevent the progression of persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). The aim of this study was to investigate dietary patterns which may be associated with hrHPV status and the risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 with CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intake was estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with a normal cervical epithelium, medium adherence to the Mediterranean diet decreased the odds of hrHPV infection when compared to low adherence (adjOR = 0.40, 95%CI = 0.22-0.73). Using the principal component analysis, we also identified two dietary patterns which explained 14.31% of the variance in food groups intake. Women in the third and fourth quartiles of the "Western pattern" had higher odds of hrHPV infection when compared with first quartile (adjOR = 1.77, 95% CI = 1.04-3.54 and adjOR = 1.97, 95%CI = 1.14-4.18, respectively). Adjusting for hrHPV status and age, women in the third quartile of the "prudent pattern" had lower odds of CIN2+ when compared with those in the first quartile (OR = 0.50, 95%CI = 0.26-0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC and discourages unhealthy habits in favour of a Mediterranean-like diet.
DOI : 10.3390/nu10040469
Anahtar Kelimeler : Mediterranean diet score, Western diet, cervical intraepithelial neoplasia, principal component analysis, prudent diet
Sınıflandırma :
19
Active Surveillance of Nosocomial Infections in Urologic Patients
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
European Urology
Yayıncı:
Elsevier
Yazar(lar) :
Antonella Agodi , Martina Barchitta , Agata Anzaldi , Francesco Marchese , Astrid Bonaccorsi , Mario Motta
Yıl :
2007
Martina Barchitta
Yayıncı Web Sitesi
Tam Metin
Kaydet
DOI : 10.1016/j.eururo.2006.05.027
ISSN: 0302-2838
Sayı: 1
Cilt: 51
Sayfa: 247-254
Sınıflandırma :
20
Epigenetic Biomarkers in Colorectal Cancer Patients Receiving Adjuvant or Neoadjuvant Therapy: A Systematic Review of Epidemiological Studies
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Molecular Sciences
Yazar(lar) :
Martina Barchitta , Andrea Maugeri , Giovanni Li Destri , Guido Basile , Antonella Agodi
Yıl :
2019
Martina Barchitta
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 Piri Tam Metin Bulucu
Kaydet
Colorectal cancer (CRC) represents the third-most common cancer worldwide and one of the main challenges for public health. Despite great strides in the application of neoadjuvant and adjuvant therapies for rectal and colon cancer patients, each of these treatments is still associated with certain adverse effects and different response rates. Thus, there is an urgent need for identifying novel potential biomarkers that might guide personalized treatments for specific subgroups of patients. However, until now, there are no biomarkers to predict the manifestation of adverse effects and the response to treatment in CRC patients. Herein, we provide a systematic review of epidemiological studies investigating epigenetic biomarkers in CRC patients receiving neoadjuvant or adjuvant therapy, and their potential role for the prediction of outcomes and response to treatment. With this aim in mind, we identified several epigenetic markers in CRC patients who received surgery with adjuvant or neoadjuvant therapy. However, none of them currently has the robustness to be translated into the clinical setting. Thus, more efforts and further large-size prospective studies and/or trials should be encouraged to develop epigenetic biomarker panels for personalized prevention and medicine in CRC cancer.
DOI : 10.3390/ijms20153842
Anahtar Kelimeler : DNA methylation, miRNA, prevention, Public Health, Epidemiology, colon cancer, rectal cancer
Cilt: 20
Sayı: 15
Sayfa: 3842
Sınıflandırma :
21
Resveratrol Modulates SIRT1 and DNMT Functions and Restores LINE-1 Methylation Levels in ARPE-19 Cells under Oxidative Stress and Inflammation.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Int J Mol Sci
Yazar(lar) :
Andrea Maugeri , Martina Barchitta , Maria Grazia Mazzone , Francesco Giuliano , Guido Basile , Antonella Agodi
Konu :
Cell Line, Cell Survival, DNA (Cytosine-5-)-Methyltransferases, Epigenomics, Glucose Oxidase, Humans, Inflammation, Lipopolysaccharides, Long Interspersed Nucleotide Elements, Methylation, Oxidative Stress, Resveratrol, Sirtuin 1, Stilbenes
Yıl :
2018
Martina Barchitta
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet
The role of epigenetic alterations in the pathogenesis of retinal degenerative diseases, including age-related macular degeneration (AMD), has been pending so far. Our study investigated the effect of oxidative stress and inflammation on DNA methyltransferases (DNMTs) and Sirtuin 1 (SIRT1) functions, as well as on long interspersed nuclear element-1 (LINE-1) methylation, in human retinal pigment epithelial (ARPE-19) cells. Therefore, we evaluated whether treatment with resveratrol may modulate DNMT and SIRT1 functions and restore changes in LINE-1 methylation. Cells were treated with 25 mU/mL glucose oxidase (GOx) or 10 µg/mL lipopolysaccharide (LPS) to mimic oxidative or inflammatory conditions, respectively. Oxidative stress decreased DNMT1, DNMT3a, DNMT3b, and SIRT1 expression (p-values < 0.05), as well as total DNMTs (-28.5%; p < 0.0001) and SIRT1 (-29.0%; p < 0.0001) activities. Similarly, inflammatory condition decreased DNMT1 and SIRT1 expression (p-values < 0.05), as well as total DNMTs (-14.9%; p = 0.007) and SIRT1 (-20.1%; p < 0.002) activities. Interestingly, GOx- and LPS-treated cells exhibited lower LINE-1 methylation compared to controls (p-values < 0.001). We also demonstrated that treatment with 10 μM resveratrol for 24 h counteracted the detrimental effect on DNMT and SIRT1 functions, and LINE-1 methylation, in cells under oxidative and inflammatory conditions. However, further studies should explore the perspectives of resveratrol as a suitable strategy for the prevention and/or treatment of retinal degenerative diseases.
DOI : 10.3390/ijms19072118
Anahtar Kelimeler : DNA methylation, epigenetics, inflammation, oxidative stress, retinal degeneration

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