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1
Design, Synthesis and X-ray Crystal Structure of Iodinated Benzoboroxole Derivatives by Consecutive Metal-Iodine Exchange of 3,4,5-Triiodoanisole
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
European Journal of Organic Chemistry
Yazar(lar) :
Raed M. Al-Zoubi , Mazhar S. Al-Zoubi , Khaled T. Jaradat , Robert McDonald
Konu :
Physical and Theoretical Chemistry, Organic Chemistry
Yıl :
2017
Mazhar S. Al-Zoubi
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A series of iodinated benzoboroxoles was designed and synthesized by using a successive metal–iodine exchange reaction of 3,4,5‐triiodoanisole. The reactivity and regioselectivity of the metal‐iodine exchange are remarkably controlled and provide the iodinated products in good yields. The synthesized iodobenzoboroxoles were screened for in vitro antimicrobial activity against two Gram‐positive strains of bacteria, Micrococcus luteus (ATCC 9341) and Bacillus cereus (ATCC 11778), and two Gram‐negative strains, Escherichia coli (ATCC 25922) and Serratia marcescens (ATCC 27117), by using a well‐diffusion assay and dilution methods. The in vitro antimicrobial evaluation indicated that 4‐iodo‐6‐methoxybenzo[c][1,2]oxaborol‐1(3H)‐ol (compound 24) possesses the most‐potent antibacterial activity against Gram‐positive strains with a minimum inhibitory concentration (MIC) of 0.016 and 0.013 mg/mL for Micrococcus luteus and Bacillus cereus, respectively. This report discloses a two‐step protocol for the synthesis of hitherto unknown 4‐iodobenzoboroxole and 7‐iodobenzoboroxole derivatives that is efficient, general in scope and scalable.
DOI : 10.1002/ejoc.201700989
ISSN: 1434-193X
Sayı: 38
Cilt: 2017
Sayfa: 5800-5808
2
Terminal versus Internal Diiodobenzyl Alcohol Derivatives via Regioselective Metal-Iodine Exchange of 1,2,3-Triiodoarenes: Synthesis and Antibacterial Activity
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Asian Journal of Organic Chemistry
Yazar(lar) :
Raed M. Al-Zoubi , Mazhar S. Al-Zoubi , Ayham H. Abazid , Robert McDonald
Yıl :
2015
Mazhar S. Al-Zoubi
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A wide range of unique diiodobenzyl alcohol building blocks have been synthesized by regioselective metal‐iodine exchange (MIE) reactions using isopropylmagnesium chloride is reported. Remarkably, the regioselectivity of the MIE reaction is easily controlled by both the aldehydes and the 1,2,3‐triiodoarenes to provide either the internal or the terminal products in good yields and in a highly regioselective fashion. The synthesized diiodobenzyl alcohols were tested for in vitro antibacterial activity against two Gram‐positive strains, Micrococcus luteus (ATCC 934) and Staphylococcus aureus (ATCC 29213), and two Gram‐negative strains, Escherichia coli (ATCC 25922) and Serratia marcescens (ATCC 27117). The biological data clearly shows that all tested diiodobenzyl alcohols have selective antibacterial activity against Gram‐positive strains and no activity against Gram‐negative ones. This report discloses a facile protocol for the synthesis of hitherto unknown ortho‐diiodobenzyl alcohol and 2,3‐diiodobenzyl alcohol derivatives in only one step that is quite general in scope and scalable, with products that are hard to make by any other means.
DOI : 10.1002/ajoc.201402288
ISSN: 2193-5807
Sayı: 4
Cilt: 4
Sayfa: 359-367
Sınıflandırma :
3
SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
MDPI
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Pathogens
Yayıncı:
MDPI AG
Yazar(lar) :
Firas A. Rabi , Mazhar S. Al Zoubi , Ghena A. Kasasbeh , Dunia M. Salameh , Amjad D. Al-Nasser
Yıl :
2020
Mazhar S. Al Zoubi
Tam Metin
Kaydet Alıntıla
In December 2019, a cluster of fatal pneumonia cases presented in Wuhan, China. They were caused by a previously unknown coronavirus. All patients had been associated with the Wuhan Wholefood market, where seafood and live animals are sold. The virus spread rapidly and public health authorities in China initiated a containment effort. However, by that time, travelers had carried the virus to many countries, sparking memories of the previous coronavirus epidemics, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and causing widespread media attention and panic. Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. Here we present a summary of current knowledge regarding the novel coronavirus and the disease it causes.
DOI : 10.3390/pathogens9030231
ISSN: 2076-0817
Sayı: 3
Cilt: 9
Sayfa: 231
Sınıflandırma :
4
Negative histology in surgically managed tubal ectopic pregnancy
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Gynecology & Obstetrics
Yazar(lar) :
Qasem J. Shehab , Lucasta Dolloway , Amal M. Damra , Mazhar S. Al Zoubi , Soha N. Albeitawi
Yıl :
2021
Mazhar S. Al Zoubi
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DOI : 10.1002/ijgo.13913
ISSN: 0020-7292
5
Coronaviruses in children: A review of potential mechanisms of childhood protection
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Acta Paediatrica
Yazar(lar) :
Firas A. Rabi , Mazhar S. Al Zoubi , Montaha Mohammed Alu2010Iede , Ghena Kasasbeh , Eman Farouk Badran
Konu :
Pediatrics, Perinatology, and Child Health, General Medicine
Yıl :
2021
Mazhar S. Al Zoubi
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DOI : 10.1111/apa.15691
ISSN: 0803-5253
Sayı: 3
Cilt: 110
Sayfa: 765-772
6
Stem Cell‐Related Knowledge and Attitudes among Physicians in Jordan
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Clinical Practice
Yazar(lar) :
Khalid A. Kheirallah , Fayez Abdulrazeq , Abdallah Alzoubi , Jomana W. Alsulaiman , Nasr Alrabadi , Mahmoud A. Alfaqih , Mazhar S. Al Zoubi , Monica M. Matsumoto
Konu :
General Medicine
Yıl :
2021
Mazhar S. Al Zoubi
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Kaydet Alıntıla
DOI : 10.1111/ijcp.14142
ISSN: 1368-5031

7
Palladium‐Catalyzed Regioselective Coupling of Amidines and 1,2,3‐Triiodobenzenes: Facile Synthesis of 2,3‐Diiodinated N ‐Arylbenzimidamides as Potential MDM 2 and MDM 4 Inhibitors
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
ChemistrySelect
Yazar(lar) :
Raed M. Alu2010Zoubi , Walid K. Alu2010Jammal , Mazhar S. Alu2010Zoubi , Michael J. Ferguson , Ahmad Zarour , Aksam Yassin , Abdulla Alu2010Ansari
Yıl :
2021
Mazhar S. Al‐Zoubi
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A facile and unprecedented synthesis of 2,3‐diiodinated N‐arylbenzimidamide derivatives through highly regioselective Buchwald‐Hartwig coupling of 5‐substituted‐1,2,3‐triiodobenzene and amidine is described. Remarkably, the amination reactions are proceeded exclusively at the terminal positions, the less sterically hindered, and the most regioactive positions. The highest yields were isolated from a combination between electron‐poor 1,2,3‐triiodoarenes and electron‐poor benzimidamides. The optimized conditions were found to be suitable for many functional groups. This report discloses the first method to make 2,3‐diiodinated N‐arylbenzimidamides that is efficient, general in scope, highly regioselective, and truly remarkable precursors for other transformations
DOI : 10.1002/slct.202100671
ISSN: 2365-6549
Sayı: 14
Cilt: 6
Sayfa: 3417-3423
8
4,977‐bp human mitochondrial DNA deletion is associated with asthenozoospermic infertility in Jordan
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Andrologia
Yazar(lar) :
Mazhar S. Al Zoubi , Khalid Alu2010Batayneh , Mohammad Alsmadi , Mitri Rashed , Bahaa Alu2010Trad , Wesam Al Khateeb , Alaa Aljabali , Osama Otoum , Mohammad Alu2010Talib , Osamah Batiha
Konu :
Urology, Endocrinology, General Medicine
Yıl :
2019
Mazhar S. Al Zoubi
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Male infertility is commonly associated with sperm abnormalities including asthenozoospermia. The molecular basis of asthenozoospermia was linked to mitochondrial DNA (mtDNA) mutations. The 4,977‐bp human mtDNA deletion is one of the most common mutations of spermatozoa and results in loss of about 33% of the mitochondrial genome. In this preliminary study, we aimed to investigate the presence of 4,977‐bp mtDNA deletion in asthenozoospermic infertile men in Jordan. Semen specimens of 120 asthenozoospermic infertile men and 80 normozoospermic individuals were collected at the in vitro fertilization unit. MtDNA was extracted after the enrichment of spermatozoa; then, polymerase chain reaction was performed using 4,977‐bp mtDNA deletion‐specific primers. The deletion of 4,977‐bp mtDNA was detected in 79.2% of asthenozoospermic patients compared to 10% in normozoospermic controls. The results showed a significant association between the presence of 4,977‐bp mtDNA deletion and the asthenozoospermia and infertility (OR = 34.2000, 95% CI = 14.57–80.26, p‐value < .001). In conclusion, our findings underscored a strong association between 4,977‐bp mtDNA deletion and asthenozoospermia in the Jordanian population.
DOI : 10.1111/and.13379
ISSN: 0303-4569
Sayı: 1
Cilt: 52

9
Palladium-catalyzed highly regioselective Buchwald-Hartwig amination of 5-substituted-1,2,3-triiodobenzene: Facile synthesis of 2,3-diiodinated N-arylanilines as potential anti-inflammatory candidates
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Organometallic Chemistry
Yayıncı:
Elsevier BV
Yazar(lar) :
Raed M. Al-Zoubi , Noor H. Al-Shatnawi , Walid K. Al-Jammal , Abdlateef Ibdah , Mazhar S. Al-Zoubi , Michael J. Ferguson , Ahmad Zarour , Aksam Yassin , Abdulla Al-Ansari
Yıl :
2021
Mazhar S. Al-Zoubi
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Kaydet Alıntıla
A facile synthesis of 2,3-diiodinated N-arylaniline derivatives via highly regioselective Buchwald-Hartwig amination of 5-substituted-1,2,3-triiodobenzene is described. Remarkably, the amination reactions proceeded exclusively at the terminal positions, the less sterically hindered and the most regioactive positions. The highest yields were isolated from electron-poor/neutral 1,2,3-triiodoarenes and electron-poor anilines. The optimized reaction conditions were found to be tolerant for a wide range of different functional groups. This report discloses the first and unprecedent method to make 2,3-diiodinated N-arylanilines that is efficient, general in scope, highly regioselective and truly remarkable precursors for other transformations.
DOI : 10.1016/j.jorganchem.2021.121786
Anahtar Kelimeler : 2, 3-diiodinated N-arylaniliness, Buchwald-Hartwig cross-coupling, Regioselectivity, Triiodoarenes, Catalysis
ISSN: 0022-328X
Cilt: 940
Sayfa: 121786
10
Gold-coated plant virus as computed tomography imaging contrast agent
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Beilstein Journal of Nanotechnology
Yazar(lar) :
Alaa A. A. Aljabali , Mazhar S. Al Zoubi , Khalid M. Al-Batanyeh , Ali Al-Radaideh , Mohammad A. Obeid , Abeer Al Sharabi , Walhan Alshaer , Bayan AbuFares , Tasnim Al-Zanati , Murtaza M. Tambuwala , Naveed Akbar , David J. Evans
Yıl :
2019
Mazhar S. Al Zoubi
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types.
DOI : 10.3762/bjnano.10.195
Anahtar Kelimeler : biomedical imaging, computed tomography (ct), nanotechnology, viruses, targeting
ISSN: 2190-4286
Cilt: 10
Sayı: 1
Sayfa: 1983 - 1993
Sınıflandırma :
11
Heat shock proteins gene expression and physiological responses in durum wheat (Triticum durum) under salt stress
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Physiology and Molecular Biology of Plants
Yazar(lar) :
Wesam Al Khateeb , Riyadh Muhaidat , Sanaa Alahmed , Mazhar S. Al Zoubi , Khalid M. Al-Batayneh , Ahmad El-Oqlah , Mohammad Abo Gamar , Emad Hussein , Alaa A. Aljabali , Almuthanna K. Alkaraki
Konu :
Plant Science, Molecular Biology, Physiology
Yıl :
2020
Mazhar S. Al Zoubi
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Kaydet Alıntıla
Salt stress is a major abiotic stress causing adverse effects on plant growth and development. The aim of this study was to investigate the effect of NaCl stress on growth, stress indicator parameters (lipid peroxidation, chlorophyll content and proline content), yield, and the expression of heat shock proteins genes (Hsp17.8, Hsp26.3, Hsp70 and Hsp101) of five Jordanian durum wheat (Triticum durum) landraces. Plants were irrigated with tap water as control or 200 mM NaCl. Significant differences among the 5 Triticum durum landraces in terms of growth parameters, stress indicator parameters, and expression of heat shock proteins genes were observed. Salt stressed landraces demonstrated decreased growth, increased levels of stress indicator parameters, and upregulation in Hsp17.8, Hsp26.3, Hsp70 and Hsp101 expression. Landraces T11 and M23 showed the highest growth, lowest levels of stress indicator parameters, and high expression of heat shock protein genes under NaCl stress. Whereas, J2 and A8 landraces showed the lowest growth, highest levels of stress indicator parameters and low expression of heat shock protein genes under NaCl stress. In conclusion, NaCl stress caused significant reduction in growth parameters, increased level of lipid peroxidation and proline content and upregulation in heat shock proteins gene expression levels. Growth, stress indicator parameters and gene expression results suggest that T11 and M23 landraces are the most NaCl stress tolerant landraces and could be used to enhance the gene pool in wheat breeding programs.
DOI : 10.1007/s12298-020-00850-x
Anahtar Kelimeler : Triticum durum, Salinity, HSP, Expression, Proline
ISSN: 0971-5894 0974-0430
Sayı: 8
Cilt: 26
Sayfa: 1599-1608
12
Mild, Efficient, and Regioselective Synthesis of Diiodophenyl­boronic Acid Derivatives via Metal–Iodine Exchange of 5-Substituted 1,2,3-Triiodoarenes
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Synthesis
Yayıncı:
Thieme Publishing Group
Yazar(lar) :
Abdellatif Ibdah , Robert McDonald , Raed M. Al-Zoubi , Ahmad A. Almasalma , Walid K. Al-Jammal , Mazhar S. Al-Zoubi
Yıl :
2018
Mazhar S. Al-Zoubi
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1055/s-0036-1589114
Cilt: 50
Sayı: 2
Sayfa: pp. 384-390
Yayın Tarihi: 2018-01-18
13
Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Journal of Gastrointestinal Cancer
Yazar(lar) :
Nighat Gull , Fareeha Arshad , Gowhar A. Naikoo , Israr Ul Hassan , Mona Zamani Pedram , Arif Ahmad , Alaa A. A. Aljabali , Vijay Mishra , Saurabh Satija , Nitin Charbe , Poonam Negi , Rohit Goyal , Ángel Serrano-Aroca , Mazhar S. Al Zoubi , Mohamed El-Tanani , Murtaza M. Tambuwala
Konu :
Gastroenterology, Oncology
Yıl :
2022
Mazhar S. Al Zoubi
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Among all forms of cancers, hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. There are several treatment options for HCC ranging from loco-regional therapy to surgical treatment. Yet, there is high morbidity and mortality. Recent research focus has shifted towards more effective and less toxic cancer treatment options. Curcumin, the active ingredient in the Curcuma longa plant, has gained widespread attention in recent years because of its multifunctional properties as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. A systematic search of PubMed, Embase and Google Scholar was performed for studies reporting incidence of HCC, risk factors associated with cirrhosis and experimental use of curcumin as an anti-cancer agent. This review exclusively encompasses the anti-cancer properties of curcumin in HCC globally and it’s postulated molecular targets of curcumin when used against liver cancers. This review is concluded by presenting the current challenges and future perspectives of novel plant extracts derived from C. longa and the treatment options against cancers.
DOI : 10.1007/s12029-022-00809-z
Anahtar Kelimeler : Cancer, Curcumin, Hepatocellular Carcinoma, Anticancer
ISSN: 1941-6628 1941-6636
14
Overview of key molecular and pharmacological targets for diabetes and associated diseases
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Life Sciences
Yayıncı:
Elsevier BV
Yazar(lar) :
Seyed Hossein Shahcheraghi , Alaa A.A. Aljabali , Mazhar S. Al Zoubi , Vijay Mishra , Nitin B. Charbe , Yusuf A. Haggag , Garima Shrivastava , Abdulmajeed G. Almutary , Abdullah M. Alnuqaydan , Debmalya Barh , Kamal Dua , Dinesh K. Chellappan , Gaurav Gupta , Marzieh Lotfi , Ángel Serrano-Aroca , Bojlul Bahar , Yogendra Kumar Mishra , Kazuo Takayama , Pritam Kumar Panda , Hamid A. Bakshi , Murtaza M. Tambuwala
Yıl :
2021
Mazhar S. Al Zoubi
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Diabetes epidemiological quantities are demonstrating one of the most important communities' health worries. The essential diabetic difficulties are including cardiomyopathy, nephropathy, inflammation, and retinopathy. Despite developments in glucose decreasing treatments and drugs, these diabetic complications are still ineffectively reversed or prohibited. Several signaling and molecular pathways are vital targets in the new therapies of diabetes. This review assesses the newest researches about the key molecules and signaling pathways as targets of molecular pharmacology in diabetes and diseases related to it for better treatment based on molecular sciences. The disease is not cured by current pharmacological strategies for type 2 diabetes. While several drug combinations are accessible that can efficiently modulate glycemia and mitigate long-term complications, these agents do not reverse pathogenesis, and in practice, they are not established to modify the patient's specific molecular profiling. Therapeutic companies have benefited from human genetics. Genome exploration, which is agnostic to the information that exists, has revealed tens of loci that impact glycemic modulation. The physiological report has begun to examine subtypes of diseases, illustrate heterogeneity and propose biochemical therapeutic pathways.
DOI : 10.1016/j.lfs.2021.119632
Anahtar Kelimeler : EC Endothelial cell, Endothelial cell, AGE Advanced Glycation End Products, Advanced Glycation End Products, ECD Endothelial Cell Dysfunction, Endothelial Cell Dysfunction, DCM Diabetic cardiomyopathy, Diabetic cardiomyopathy, PPARα Peroxisome proliferator-activated receptor α, Peroxisome proliferator-activated receptor α, GLP-1 Glucagon like peptide-1, Glucagon like peptide-1, YAP Yes-associated protein, Yes-associated protein, PRR Pro renin receptor, Pro renin receptor, Ad-PRR Adenoviruses-carried-PRR-gene, Adenoviruses-carried-PRR-gene, LXA4 Lipoxin A4, Lipoxin A4, O-GlcNAc O-linked N-acetylglucosamine, O-linked N-acetylglucosamine, ROS Reactive oxygen species, Reactive oxygen species, PKCβ Protein kinase C β, Protein kinase C β, PKB or Akt Protein kinase B, Protein kinase B, PI3K Phosphoinositide 3-kinase, Phosphoinositide 3-kinase, PKR Protein kinase RNA, Protein kinase RNA, IRE1 Inositol-requiring enzyme-1, Inositol-requiring enzyme-1, BMP9 Bone morphogenetic protein-9, Bone morphogenetic protein-9, HMGB1 High-mobility group box 1 protein, High-mobility group box 1 protein, TLR4 Toll-like receptor 4, Toll-like receptor 4, TGF-β Transforming growth factor beta, Transforming growth factor beta, VEGF Vascular endothelial growth factor, Vascular endothelial growth factor, MAPK Mitogenactivated protein kinase, Mitogenactivated protein kinase, HIF-1 Hypoxia inducible factor-1, Hypoxia inducible factor-1, DR Diabetic retinopathy, Diabetic retinopathy, miRNAs microRNAs, microRNAs, T2D Type 2 diabetes, Type 2 diabetes, DN Diabetic nephropathy, Diabetic nephropathy, NF-κB Nuclear factor-κB, Nuclear factor-κB, GPR120 G protein-coupled receptor 120, G protein-coupled receptor 120, GPER G protein-coupled estrogen receptor, G protein-coupled estrogen receptor, TNF-α Tumor necrosis factor- alpha, Tumor necrosis factor- alpha, Nrf-2 Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid 2-related factor 2, JNK c-Jun amino terminal kinase, c-Jun amino terminal kinase, BHB β-hydroxybutyrate, β-hydroxybutyrate, HSPs Heat shock proteins, Heat shock proteins, GSK-3β Glycogen synthesis kinase-3β, Glycogen synthesis kinase-3β, mTOR mammalian target of rapamycin, mammalian target of rapamycin, ICAM-1 Intercellular adhesion molecule 1, Intercellular adhesion molecule 1, Diabetes, Diabetic complications, Signaling pathways, Molecular pharmacology, Targets
ISSN: 0024-3205
Cilt: 278
Sayfa: 119632
15
Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Nutrients
Yazar(lar) :
Hamid A. Bakshi , Mazhar S Al Zoubi , Hakkim L. Faruck , Alaa A A Aljabali , Firas A. Rabi , Amin A. Hafiz , Khalid M Al-Batanyeh , Bahaa Al-Trad , Prawej Ansari , Mohamed M. Nasef , Nitin B. Charbe , Saurabh Satija , Meenu Mehta , Vijay Mishra , Gaurav Gupta , Salem Abobaker , Poonam Negi , Ibrahim M. Azzouz , Ashref Ali K Dardouri , Harish Dureja , Parteek Prasher , Dinesh K. Chellappan , Kamal Dua , Mateus Webba Da Silva , Mohamed El Tanani , Paul A. McCarron , Murtaza M. Tambuwala
Yıl :
2020
Mazhar S Al Zoubi
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
DOI : 10.3390/nu12061901
Anahtar Kelimeler : pancreatic cancer, crocin, apoptosis, cell cycle, radiation, hepatic injury
ISSN: 2072-6643
Cilt: 12
Sayı: 1901
Sayfa: 1901
Sınıflandırma :
Biyotıp %100
Biyotıp %100
16
Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
MDPI
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
Cancers
Yayıncı:
MDPI AG
Yazar(lar) :
Alaa A. A. Aljabali , Hamid A. Bakshi , Faruck L. Hakkim , Yusuf A. Haggag , Khalid M. Al-Batanyeh , Mazhar S. Al Zoubi , Bahaa Al-Trad , Mohamed M. Nasef , Saurabh Satija , Meenu Mehta , Kavita Pabreja , Vijay Mishra , Mohammed Khan , Salem Abobaker , Ibrahim M. Azzouz , Harish Dureja , Ritesh M. Pabari , Ashref Ali K. Dardouri , Prashant Kesharwani , Gaurav Gupta , Shakti Dhar Shukla , Parteek Prasher , Nitin B. Charbe , Poonam Negi , Deepak N. Kapoor , Dinesh Kumar Chellappan , Mateus Webba da Silva , Paul Thompson , Kamal Dua , Paul McCarron , Murtaza M. Tambuwala
Yıl :
2020
Mazhar S. Al Zoubi
Tam Metin
Kaydet Alıntıla
Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC–BSA nanoparticles (NPs). These PIC–BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC–BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC–BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC–BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC–BSA NPs, enhances its therapeutic potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients.
DOI : 10.3390/cancers12010113
ISSN: 2072-6694
Sayı: 1
Cilt: 12
Sayfa: 113
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