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A Preventive Role of Exercise Across the Coronavirus 2 (SARS-CoV-2) Pandemic
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Physiology
Yazar(lar) :
Meizi Wang , Meizi Wang , Julien S. Baker , Wenjing Quan , Siqin Shen , Gusztáv Fekete , Yaodong Gu
Yıl :
2020
Meizi Wang Meizi Wang
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The coronavirus 2019 (COVID-19) pandemic has posed a significant threat to human health around the world. A severe risk of infection has been observed in elderly populations. In addition, individuals with obesity and obesity-related comorbidities have also been identified to be at a higher risk of infection for COVID-19. We have attempted here to provide evidence in support of exercise management as a prevention strategy for improving health and minimizing the effects of COVID-19. Therefore, exercise duration, frequency, and intensity benefits are summarized in an attempt to provide guidelines for the general population. In terms of exercise effects, there are multiple benefits of exercise related to human health. These include, decreases in adipose tissue, improvements in cardio-respiratory fitness, enhanced metabolic homeostasis, and suppress inflammation active. With respect to the amount of exercise performed individuals should exercise at a moderate intensity for at least 150 min/wk as an initial target. Increases in intensity and duration of exercise training are necessary for significant fitness benefits, weight loss, and prevention of weight regain. In relation to walking, 10,000 steps/day at a rate of 64–170 steps/minute for at least 10 min duration is reasonable for healthy adults. For exercise intensity, a combination of resistance training (RT), aerobic training (AT) as well as high-intensity interval training (HIIT) incorporated with moderate-intensity continuous training (MICT) can be recognized as an optimal exercise mode for health benefits. Aerobic training and MICT should be viewed as a basis for exercise in combination with appropriate volumes and types of RT and HIIT. Activities should be performed according to professional guidelines and advice. If implemented, these measures may reduce infection rates, underlying pathologies, and assist in decreasing mortality associated with COVID-19 pandemic.
DOI : 10.3389/fphys.2020.572718
Anahtar Kelimeler : coronavirus 2019, obesity, overweight, exercise, health
ISSN: 1664-042X
Cilt: 11
Sınıflandırma :
2
Analysis of foot kinematics wearing high heels using the Oxford foot model.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Technol Health Care
Yazar(lar) :
Meizi Wang , Yaodong Gu , Julien Steven Baker
Yıl :
2018
Meizi Wang
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 Piri Tam Metin Bulucu
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Wearing high heels is thought to lead to various foot disorders and injuries such as metatarsal pain, Achilles tendon tension, plantar fasciitis and Haglund malformation. However, there is little available information explaining the specific mechanisms and reasons why wearing high heels causes foot deformity. Therefore, the purpose of this study was to investigate the foot kinematics of high heel wearers and compare any differences with barefoot individuals using the Oxford Foot Model (OFM). Fifteen healthy women aged 20-25 years were measured while walking barefoot and when wearing high heels. The peak value of angular motion for the hallux with respect to the forefoot, the forefoot with respect to the hind foot, and the hind foot with respect to the tibia were all analyzed. Compared to the barefoot, participants wearing high heels demonstrated larger hallux dorsiflexion (22.55∘± 1.62∘ VS 26.6∘± 2.33∘ for the barefoot; P= 0.001), and less hallux plantarflexion during the initial stance phase (-4.86∘± 2.32∘ VS -8.68∘± 1.13∘; P< 0.001). There were also greater forefoot adduction (16.15∘± 1.37∘ VS 13.18∘± 0.79∘; P< 0.001), but no significant differences were found in forefoot abduction between the two conditions. The hind foot demonstrated a larger dorsiflexion in the horizontal plane (16.59∘± 1.69∘ VS 12.08∘± 0.9∘; P< 0.001), greater internal rotation (16.72∘± 0.48∘ VS 7.97∘± 0.55∘; P< 0.001), and decreased peak hind foot extension rotation (-5.49∘± 0.69∘ VS -10.73∘± 0.42∘; P= 0.001). These findings complement existing kinematic evidence that wearing high heels can lead to foot deformities and injuries.
DOI : 10.3233/THC-181264
Anahtar Kelimeler : High heels, Oxford foot model, gait, hallux valgus
3
The effect of voluntary head movements on postural kinetics in the standing cat
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Yazar(lar) :
Yang Song , Meizi Wang , Julien Steven Baker , Yaodong Gu
Yıl :
2019
Meizi Wang
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Tam Metin
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Background Although the postural instability accompanying bilateral vestibular loss in human and quadrupeds during lateral head movements are well-known, it is still unclear whether or not lateral head turns would indeed activate the postural control system to maintain balance. This study aimed to examine the kinetic parameters in freely standing intact cats during head movements in order to further answer the above question. Methods Six intact cats were trained to stand, unrestrained on a force plate and perform voluntary head movements to the left and right positions in response to visual cues. Each trial was divided into two phases, quiet standing with the cat’s head maintaining a straight forward and lateral head position after voluntary head movements. Kinetic parameters including peak pressure and contact area under each limb as well as center of pressure (COP) displacements of the whole body were measured. Results Compared to the neutral head position, peak pressure and contact area of the left head position were significantly smaller for the left forelimb while greatly larger for the right forelimb. An exact opposite case of peak pressure and contact area in the forelimbs was found between the right and neutral head positions. In addition, the COP displacements altered oppositely to the head movements, and presented a significantly right shift in the left position and a significantly left shift in the right position. Conclusion These results demonstrate that the lateral displacement of the head in standing intact cats does activate the postural adjustment to maintain balance, which is consistent with the concept that vestibular input can contribute to postural balance during voluntary head turns.
DOI : 10.7717/peerj.8186
Anahtar Kelimeler : Postural control, voluntary head movement, Kinetics
ISSN: 2167-8359
Cilt: 7
Sayfa: e8186
Sınıflandırma :
Biyotıp %80
4
Kinetic analysis of felines landing from different heights
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Yazar(lar) :
Meizi Wang , Yang Song , Stephanie Valentin , Julien S. Baker , Yaodong Gu
Yıl :
2019
Meizi Wang
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Kaydet Alıntıla
Background Kinetic motion analysis has been used in canines and equines as a fundamental objective evaluation measurement. Cats are very capable jumpers, and this ability has biomimetic applications. It is essential to understand movement patterns and physical adaptations of this species, as cats are popular pets for humans. Further to this, motion analysis of a cat’s movement patterns may provide potentially valuable information in relation to limb disease and injury. Therefore, the aim of this study was to investigate kinetic differences in cats when landing from varying preselected controlled heights. Methods The peak vertical force (PVF) and paw contact area (CA) of both the forelimbs and hindlimbs were collected from seven healthy Chinese domesticated cats while landing from heights of 30 cm, 50 cm, 70 cm and 90 cm respectively. The falling motivation for the cats was facilitated with the use of a flip board. This device provided the basis for the cats to land passively. Results The results indicated that the PVF of all examined limbs (fore right, fore left, hind right, hind left) significantly increased as the height increased. When the PVF from the hindlimbs and forelimbs were compared, the forelimbs recorded significantly greater values for all heights examined (P < 0.001). The PVF of the hindlimbs was symmetrical at all heights, but forelimb symmetry only occurred at the lower heights. The hindlimbs demonstrated larger CA than the forelimbs measured from all heights on landing (P < 0.001). Moreover, the paw CA on the left and right limbs were symmetrical. Discussion The paw CA of cats may be an effective parameter to evaluate abnormalities or diseases in the limbs of cats. Additionally, these findings highlight how cats land from varying heights, which may also provide reference values for the bionic design of artificial limbs for felines and treatment for limb diseases in this species.
DOI : 10.7717/peerj.8007
Anahtar Kelimeler : Landing, Motion analysis, Kinetics, Bionics design
ISSN: 2167-8359
Cilt: 7
Sayfa: e8007
5
Comparative Study of Kinematics and Muscle Activity Between Elite and Amateur Table Tennis Players During Topspin Loop Against Backspin Movements.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
J Hum Kinet
Yazar(lar) :
Meizi Wang , Lin Fu , Yaodong Gu , Qichang Mei , Fengqin Fu , Justin Fernandez
Yıl :
2018
Meizi Wang
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This study investigated differences of lower limb kinematics and muscle activity during table tennis topspin loop against backspin movements between elite players (EPs) and amateur players (APs). Ten EPs and ten APs performed crosscourt backhand loop movements against the backspin ball with maximal power. Vicon motion analysis and a MEGA ME6000 system was used to capture kinematics and surface EMG data. The motion was divided into two phases, including the backswing and swing. The joints' flexion and extension angle tendency between EPs and APs differed significantly. The coefficient of multiple correlation (CMC) values for EPs were all beyond 0.9, indicating high similarity of joint angles change. APs presented moderate similarity with CMC values from 0.5 to 0.75. Compared to APs, EPs presented larger ankle eversion, knee and hip flexion at the beginning moment of the backswing. In the sEMG test, EPs presented smaller standardized AEMG (average electromyography) of the lower limb muscles in the rectus femoris and tibia anterior on both sides. Additionally, the maximum activation of each muscle for EPs was smaller and MPF (mean power frequency) of the lower limb was greater during the whole movement. The present study revealed that EPs could complete this technical motion more economically than APs, meanwhile, EPs were more efficient in muscle usage and showed better balance ability.
DOI : 10.1515/hukin-2017-0182
Anahtar Kelimeler : EMG, backhand loop, kinematics, skilled level, table tennis
Sınıflandırma :
6
Analyzing the effect of an arch support functional insole on walking and jogging in young, healthy females.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Technol Health Care
Yazar(lar) :
Xiaoxue Zhao , Meizi Wang , Gusztáv Fekete , Julien S Baker , Huw Wiltshire , Yaodong Gu
Yıl :
2018
Meizi Wang
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The aim of this study was to explore the effectiveness of arch support functional insoles to prevent metatarsalgia.
DOI : 10.3233/THC-181373
Anahtar Kelimeler : Arch support, biomechanics, gait, insoles
Sınıflandırma :
7
Inhibitory interaction of narcissoside on α-glucosidase from Aspergillus niger and Saccharomyces cerevisiae by spectral analysis and molecular docking
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Molecular Structure
Yayıncı:
Elsevier BV
Yazar(lar) :
Yangyang Fan , Yanzhou Tao , Suqing Wang , Meizi Wang , Li Li
Yıl :
2022
Meizi Wang
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Kaydet Alıntıla
Inhibition of α-glucosidase was an effective method to control postprandial hyperglycemia due to it could reduce postprandial hyperglycemia. Narcissoside was a natural flavonoid with anti-diabetic effect, however, the inhibitory interaction of α-glucosidase by narcissoside were not reported. The inhibition interaction of narcissoside on the two sources of α-glucosidase from Aspergillus niger (A. niger) (ANG) and Saccharomyces cerevisiae (S. cerevisiae) (SCG) were explored based on spectral analysis coupled with molecular docking in this study. The fluorescence analysis suggested that the ANG and SCG were statically quenched by narcissoside. Meanwhile, narcissoside was bound to ANG more strongly than it did to SCG at the same temperature. Spectral analysis indicated that the conformation of ANG and SCG were altered after binding to narcissoside. The homologous protein of ANG and SCG were constructed to obtain accurate docking results, and the result confirmed that narcissoside occupied the active region of ANG and SCG by hydrogen bond and Van der Waals force. Thereby, narcissoside might be a potentially active ingredient for the prevention or treatment of Type 2 diabetes.
DOI : 10.1016/j.molstruc.2022.133262
Anahtar Kelimeler : Narcissoside, Two α-glucosidase, Spectral analysis, Molecular docking
ISSN: 0022-2860
Sayfa: 133262
8
Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak 1:
Directory of Open Access Journals (DOAJ)
Kaynak 2:
MDPI
Dergi:
International Journal of Environmental Research and Public Health
Yazar(lar) :
Yang Song , Feng Ren , Dong Sun , Meizi Wang , Julien S. Baker , Bíró István , Yaodong Gu
Yıl :
2020
Meizi Wang
Piri Tam Metin Bulucu
Kaydet Alıntıla
A coronavirus pandemic has recently become one of the greatest threats the world is facing. Older adults are under a high risk of infection because of weaker immune systems. Therefore, the purpose of this review is to summarize the recent scientific evidence that outlines the effects of exercise on influenza or pneumonia in older adults. An electronic literature search was conducted using the WEB OF SCIENCE, SCIENCEDIRECT and GOOGLE SCHOLAR databases using the following keywords, “Exercise,” “Older adult,” “Influenza,” and “Pneumonia.” Any randomized control trials, cross-sectional and observational studies that related to this topic were all included. Twenty studies met the eligibility criteria for this review. Thirteen randomized control trials investigated the effects of exercise on the immune responses to influenza or pneumonia vaccination: seven trials employed moderate aerobic exercise, three employed resistance exercise, and the remaining three used Asian martial arts or special home-based exercises. Five cross-sectional and two observational studies examined the associations between exercise/physical condition and influenza/pneumonia. Most of the current studies suggested that prolonged moderate aerobic exercise may help to reduce the risk of influenza-related infection and improve the immune responses to influenza or pneumonia vaccination in older adults. In addition, training in traditional Asian martial arts was also found to be beneficial. Future research should focus on the different effects of moderate and vigorous exercise on influenza-related diseases.
DOI : 10.3390/ijerph17082655
Anahtar Kelimeler : exercise, influenza, pneumonia, older adults
Cilt: 17
Sayı: 2655
Sayfa: 2655
Sınıflandırma :
9
Interaction mechanism of pelargonidin against tyrosinase by multi‐spectroscopy and molecular docking
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
Wiley Online Library
Kaynak 2:
Wiley Online Library
Dergi:
Journal of Molecular Recognition
Yazar(lar) :
Yanzhou Tao , Rongda Chen , Yangyang Fan , Guiming Liu , Meizi Wang , Suqing Wang , Li Li
Yıl :
2022
Meizi Wang
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/jmr.2955
ISSN: 0952-3499
10
Interaction study of engeletin toward cytochrome P450 3A4 and 2D6 by multi-spectroscopy and molecular docking
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Yayıncı:
Elsevier BV
Yazar(lar) :
Yangyang Fan , Yanzhou Tao , Guiming Liu , Meizi Wang , Suqing Wang , Li Li
Yıl :
2022
Meizi Wang
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Kaydet Alıntıla
The inhibitory effects of engeletin on the activities of human cytochrome P450 3A4 and 2D6 (CYP3A4 and CYP2D6) were investigated by enzyme kinetics, multi-spectroscopy and molecular docking. Engeletin was found to strongly inhibit CYP3A4 and CYP2D6, with the IC50 of 1.32 μM and 2.87 μM, respectively. The inhibition modes of engeletin against CYP3A4 and CYP2D6 were a competitive type and a mixed type, respectively. The fluorescence of the two CYPs was quenched statically by engeletin, which was bound to CYP3A4 stronger than to CYP2D6 at the same temperature. Circular dichroism spectroscopy, three-dimensional fluorescence, ultraviolet–visible spectroscopy and synchronous fluorescence confirmed that the conformation and micro-environment of the two CYPs protein were changed after binding with engeletin. Molecular docking, ultraviolet–visible spectroscopy and the fluorescence data revealed that engeletin had strong binding affinity to the two CYPs through hydrogen and van der Waals forces. The findings here suggested that engeletin may cause the herb-drug interactions for its inhibition of CYP3A4 and CYP2D6 activities.
DOI : 10.1016/j.saa.2021.120311
Anahtar Kelimeler : Engeletin, CYP3A4, CYP2D6, Multi-spectroscopy, Molecular docking
ISSN: 1386-1425
Cilt: 264
Sayfa: 120311
11
Interactions of potato-derived and human recombinant 5-lipoxygenase with sec-O-glucosylhamaudol by multi-spectroscopy and molecular docking
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Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Yayıncı:
Elsevier BV
Yazar(lar) :
Guiming Liu , Yangyang Fan , Yanzhou Tao , Suqing Wang , Meizi Wang , Li Li
Yıl :
2022
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
5-lipoxygenase (5-LOX) was a key enzyme involved in many inflammatory diseases. Sec-O-glucosylhamaudol (SOG) was a chromone found in Saposhnikovia divaricata (Turcz.) Schischk (S. divaricate). The potato-derived 5-LOX (p-5-LOX) and human recombinant 5-LOX (h-5-LOX) were selected as model protein due to their simple usability and high stability in this study. Thus, the binding interactions of p-5-LOX and h-5-LOX with SOG were investigated by multi-spectroscopy and molecular docking. As a result, the fluorescence intensities of the two 5-LOX were quenched statically by SOG. However, the binding ability of SOG to h-5-LOX was higher than that of p-5-LOX at the same temperature. The results of multi-spectroscopy revealed that the conformation and micro-environment of the two 5-LOX proteins were changed after binding with SOG. Fluorescence assay and molecular docking indicated that hydrogen bond and electrostatic gravitation were the main forces between the two 5-LOX and SOG. Our results here suggested that SOG may exert anti-inflammatory effect by inhibiting 5-LOX activity.
DOI : 10.1016/j.saa.2022.121100
Anahtar Kelimeler : 5-Lipoxygenase, sec-O-glucosylhamaudol, Multi-spectroscopy, Molecular docking
ISSN: 1386-1425
Cilt: 274
Sayfa: 121100
Sınıflandırma :
12
Interaction study of astilbin, isoastilbin and neoastilbin toward CYP2D6 by multi‐spectroscopy and molecular docking
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Luminescence
Yazar(lar) :
Yanzhou Tao , Yangyang Fan , Guiming Liu , Yuhang Zhang , Meizi Wang , Xiaolin Wang , Li Li
Yıl :
2021
Meizi Wang
Yayıncı Web Sitesi
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Kaydet Alıntıla
Astilbin, isoastilbin and neoastilbin are the three flavonoid isomers prevalent in Rhizoma Smilax glabra. The interactions between human cytochrome P450 2D6 (CYP2D6) and the three isomers were investigated by multiple spectroscopic coupled with molecular docking. As a result, the fluorescence intensity of CYP2D6 was quenched statically by the three isomers. Meanwhile, astilbin had the strongest binding ability to CYP2D6, followed by isoastilbin and neoastilbin under the identical temperature. Synchronous fluorescence, three‐dimensional fluorescence, ultraviolet‐visible spectroscopy, circular dichroism and Fourier‐transform infrared spectra confirmed that the conformation and micro‐environment of CYP2D6 protein were changed after binding with the three isomers. As suggested from molecular docking, the three isomers had strong binding affinity to CYP2D6 via the bonding of hydrogen and van der Waals forces, and the results were in agreement with the fluorescence results. The findings here suggested that astilbin, isoastilbin and neoastilbin may cause the herb–drug interactions for their inhibition of CYP2D6 activity.
DOI : 10.1002/bio.4065
ISSN: 1522-7235
Sayı: 6
Cilt: 36
Sayfa: 1412-1421
13
Synthesis and biological activity of FGLamide allatostatin analogs with Phe3residue modifications
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal of Peptide Science
Yazar(lar) :
Yong Xie , Meizi Wang , Li Zhang , Xiaoqing Wu , Xinling Yang , Stephen S. Tobe
Konu :
Organic Chemistry, Molecular Medicine, Biochemistry, Molecular Biology, Pharmacology, Structural Biology, Drug Discovery, General Medicine
Yıl :
2016
Meizi Wang
Yayıncı Web Sitesi
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Kaydet Alıntıla
A FGLamide allatostatin neuropeptide mimic (H17) is a potential insect growth regulator which inhibits the production of juvenile hormone by the corpora allata. To find more evidence to reveal the structure–activity relationships of the Phe3 residue in the C‐terminal conserved pentapeptide and search for novel analogs with high activity, a series of Phe3 residue‐modified analogs were designed and synthesized using H17 as the lead compound. Bioassay using juvenile hormone (JH) production by corpora allata of the cockroach Diploptera punctata indicated that analogs 4, 11, and 13 showed strong ability to inhibit JH production in vitro, with IC50 of 38.5, 22.5, and 26 nM, respectively. As well, the activity of analog 2 (IC50: 89.5 nM) proved roughly equivalent to that of H17. Based on the primary structure–activity relationships of Phe3 residue, we suggest that for analogs containing six‐membered aromatic rings, removing the methylene group of Phe3 or an o‐halogen or p‐halogen‐substituted benzene ring could increase the ability to inhibit biosynthesis of JH. This study will be useful for the design of new allatostatin analogs for insect management. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd.
DOI : 10.1002/psc.2906
ISSN: 1075-2617
Sayı: 9
Cilt: 22
Sayfa: 600-606
14
3D-QSAR based optimization of insect neuropeptide allatostatin analogs
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Bioorganic & Medicinal Chemistry Letters
Yayıncı:
Elsevier
Yazar(lar) :
Meizi Wang , Xinlu Li , Mengting Chen , Xiaoqing Wu , Yiduo Mi , Zhenpeng Kai , Xinling Yang
Yıl :
2019
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Allatostatins (AST) are neuropeptides originally described as inhibitors of juvenile hormone (JH) synthesis in insects. Consequently, they have been considered as potential lead compounds for the discovery of new insect growth regulators (IGRs). In the present work, receptor-based three-dimensional quantitative structure-activity relationship (3D-QSAR) was studied with 48 AST analogs, and a general approach for novel potent bioactive AST analogs is proposed. Hence, six novel AST analogs were designed and synthesized. Bioassays indicated that the majority novel analogs exhibited potent JH inhibitory activity, especially analog A6 (IC50: 3.79 nmol/L), which can be used as lead compound to develop new IGRs.
DOI : 10.1016/j.bmcl.2019.02.001
Anahtar Kelimeler : Neuropeptides, Allatostatins analogs, 3D-QSAR, Optimization, IGRs
ISSN: 0960-894X
Sayı: 7
Cilt: 29
Sayfa: 890-895
15
Health View to Decrease Negative Effect of High Heels Wearing: A Systemic Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Hindawi Limited
Dergi:
Applied Bionics and Biomechanics
Yayıncı:
Hindawi
Yazar(lar) :
Meizi Wang , Ci Jiang , Gusztáv Fekete , Ee-Chon Teo , Yaodong Gu
Yıl :
2021
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Effective recommendations about how to decrease adverse effects of high heels (HH) need to be provided, since wearing HH is inevitable for most women in their daily life, regardless of their negative impacts on the foot morphology. The main purpose of this systematic review was to summarize studies which have provided specific information about how to effectively offset the negative effects of wearing HH, in the case of women, by means of examining heel height, insole, and heel base support (HBS). Some evidence indicate the following: (i) the range of appropriate heel height for HH shoes is 3.76 cm to 4.47 cm; (ii) compared to small HBS, the larger ones effectively increase gait stability, reduce risk of ankle injury, and improve comfort rating during HH walking; and (iii) the use of a total contact insert (TCI) significantly decreases plantar pressure and the impact on the foot, resulting in higher perceived comfort. It must be noted that these results are based on short-term research; therefore, any conclusions with regard to effects in the long term should be taken with a grain of salt. Nevertheless, future studies should be aimed at combining numerical and experimental methods, in order to provide personal recommendations for HH shoes by considering heel height and HBS size, based on the individual characters (weight, height, and age).
DOI : https://doi.org/10.1155/2021/6618581
Cilt: 2021
ISSN: 1176-2322
Sınıflandırma :
16
The biomechanical characteristics of a feline distal forelimb: A finite element analysis study
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Computers in Biology and Medicine
Yayıncı:
Elsevier BV
Yazar(lar) :
Meizi Wang , Yang Song , Julien S. Baker , Gusztáv Fekete , Ukadike Chris Ugbolue , Shudong Li , Yaodong Gu
Yıl :
2021
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
As a typical digitigrade mammal, the uniquely designed small distal limbs of the feline support two to three times of its body weight during daily movements. To understand how force transmission occurs in relation to the distal joint in a feline limb, which transfers bodyweight to the ground, it is necessary to examine the internal stress distribution of the distal joint limb in detail. Therefore, finite element models (FEM) of a healthy feline were established to predict the internal stress distribution of the distal limb. The FEM model included 23 bony components, various cartilaginous ligaments, as well as the encapsulated soft tissue of the paw. The FEM model was validated by comparison of paw pressure distribution, obtained from an experiment for balance standing. The results demonstrated a good agreement between the experimentally measured and numerically predicted pressure distribution in the feline paw. Additionally, higher stress levels were noted in the metacarpal segment, with smaller stresses observed in the phalanges portion including the proximal, middle, and distal segments. The raised metacarpal segment plays an important role in creating a stiff junction between the metacarpophalangeal (MCP) and wrist joint, stabilizing the distal limb. The paw pads help to optimize stress distribution in phalanx region. Findings from this study contribute to our understanding of feline distal forelimb biomechanical behavior. This information can be applied to bionic design of footwear since an optimal stiff junction and pressure distribution can be adapted to enhance injury relief and sports activities. Further developments may include progress, evaluation, and treatment of metatarsophalangeal joint injuries in human populations.
DOI : 10.1016/j.compbiomed.2020.104174
Anahtar Kelimeler : Finite element model, Feline distal limb, Feline distal joint, Bionic footwear, Inner stress distribution
ISSN: 0010-4825
Cilt: 129
Sayfa: 104174
17
Exploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Chinese Chemical Letters
Yayıncı:
Elsevier
Yazar(lar) :
Meizi Wang , Li Zhang , Xianwei Wang , Yun Ling , Xiaoqing Wu , Xinlu Li , Yiduo Mi , Xinling Yang
Yıl :
2018
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Allatostatins (ASTs), a family of insect neuropeptide, can inhibit juvenile hormone (JH) biosynthesis by the corpora allata (CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators (IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro (IC50: 0.09 μmol/L) in our previous studies. In the present work, two series of B1 analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with logP value over 2.0 exhibited good activity, which indicated the hydrophobicity is important to the bioactivity. Three dimension quantitative structure-activity relationship (3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog II12 (IC50: 0.08 μmol/L) exhibited similar inhibitory activity to the lead B1, but its synthetic route was simpler than B1. Therefore, II12 could be used as a new lead compound for the discovery eco-friendly IGRs.
DOI : 10.1016/j.cclet.2017.11.022
Anahtar Kelimeler : Allatostatins, Juvenile hormone, IGRs, AST analogs, Synthesis, 3D-QSAR
ISSN: 1001-8417
Sayı: 9
Cilt: 29
Sayfa: 1375-1378
Sınıflandırma :
Apoptoz %24
18
Temporal Kinematic Differences between Forward and Backward Jump-Landing
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
MDPI
Dergi:
International Journal of Environmental Research and Public Health
Yayıncı:
MDPI AG
Yazar(lar) :
Datao Xu , Xuanzhen Cen , Meizi Wang , Ming Rong , Bíró István , Julien S. Baker , Yaodong Gu
Yıl :
2020
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Backward jump-landing during sports performance will result in dynamic postural instability with a greater risk of injury, and most research studies have focused on forward landing. Differences in kinematic temporal characteristics between single-leg and double-leg backward jump-landing are seldom researched and understood. The purpose of this study was to compare and analyze lower extremity kinematic differences throughout the landing phases of forward and backward jumping using single-leg and double-leg landings (FS and BS, FD and BD). Kinematic data were collected during the landing phases of FS and BS, FD and BD in 45 participants. Through statistical parametric mapping (SPM) analysis, we found that the BS showed smaller hip and knee flexion and greater vertical ground reactive force (VGRF) than the FS during 0–37.42% (p = 0.031), 16.07–32.11% (p = 0.045), and 23.03–17.32% (p = 0.041) landing phases. The BD showed smaller hip and knee flexion than the FD during 0–20.66% (p = 0.047) and 0–100% (p < 0.001) landing phases. Most differences appeared within a time frame during the landing phase at 30–50 ms in which non-contact anterior cruciate ligament (ACL) injuries are thought to occur and are consistent with the identification of risk in biomechanical analysis. A landing strategy that consciously increases the knee and hip flexion angles during backward landing should be considered for people as a measure to avoid injury during the performance of this type of physical activity.
DOI : 10.3390/ijerph17186669
ISSN: 1660-4601
Sayı: 18
Cilt: 17
Sayfa: 6669
Sınıflandırma :
19
A potential insect growth regulator for cockroach control: design, synthesis and bioactivity of N-terminal-modified allatostatin analogues
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Pest Management Science
Yazar(lar) :
Xiaoqing Wu , Meizi Wang , Juan Huang , Li Zhang , Zhe Zhang , Yun Ling , Xinling Yang , Stephen S Tobe
Konu :
Agronomy and Crop Science, Insect Science, General Medicine
Yıl :
2016
Meizi Wang
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1002/ps.4444
ISSN: 1526-498X
Sayı: 3
Cilt: 73
Sayfa: 500-505
20
Baseline sensitivity and bioactivity of tetramycin against Sclerotium rolfsii isolates in Huanghuai peanut-growing region of China
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Ecotoxicology and Environmental Safety
Yayıncı:
Elsevier BV
Yazar(lar) :
Ya He , Pengqiang Du , Te Zhao , Fei Gao , Meizi Wang , Jingjing Zhang , Leiming He , Kaidi Cui , Lin Zhou
Yıl :
2022
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Peanut stem rot caused by Sclerotium rolfsii is a serious soil-borne disease and poses a threat to the peanut production. The antibiotic fungicide tetramycin has a broad antifungal spectrum against multiple pathogens and possess low environmental risks. In current study, a total of 250 isolates collected from Huanghuai peanut-growing region of China (Henan, Shandong and Hebei Province) were used to establish the baseline sensitivity of S. rolfsii to tetramycin. The baseline sensitivity curve was unimodal and distributed from 0.01 to 0.36 mg/L, with a mean EC50 (50% effective concentration) value of 0.11 ± 0.06 mg/L. Tetramycin also had strong inhibitory activity on the formation and germination of sclerotia. There was no significant correlation of S. rolfsii sensitivity to tetramycin and other commonly used SDHI (succinate dehydrogenase inhibitor), QoI (quinone outside respiration inhibitor) and DMI (demethylation inhibitor) fungicides. Moreover, tetramycin significantly increased the cell membrane permeability and reduced the oxalate acid content. Greenhouse experiments showed that tetramycin has both protective and curative efficacy against S. rolfsii, while protective efficacy was higher than curative efficacy. Anyhow, the bioactivity of tetramycin is similar (curative efficacy) or higher (protective efficacy) than the control fungicide validamycin. In terms of application method, root drench may be more suitable for tetramycin than spraying, because root drench of tetramycin obtained a higher efficacy. These results indicated that tetramycin may be a potential alternative fungicide for the efficient control of peanut stem rot.
DOI : 10.1016/j.ecoenv.2022.113580
Anahtar Kelimeler : Tetramycin, Sclerotium rolfsii, Baseline sensitivity, Root drench
ISSN: 0147-6513
Cilt: 238
Sayfa: 113580
21
Effect of Different Exercise Modalities on Oxidative Stress: A Systematic Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Hindawi Limited
Dergi:
BioMed Research International
Yayıncı:
Hindawi
Yazar(lar) :
An Thirupathi , , Meizi Wang , Ji Kai Lin , Gusztáv Fekete , Bíró István , Julien S. Baker , Yaodong Gu
Yıl :
2021
Meizi Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Exercise-induced benefits are being increasingly recognized in promoting health and preventing diseases. However, initial adaption to exercise response can have different effects on cells, including an increase in the formation of oxidants and inflammatory mediators that ultimately leads to oxidative stress, but this scenario depends on the exercise type and intensity and training status of the individual. Therefore, we aimed to understand the effect of different types of exercise on oxidative stress. Indeed, exercise-induced minimum oxidative stress is required for regulating signaling pathways. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search for relevant articles was carried out on PubMed/Medline, ISI Web of Science, and Google Scholar using a broad range of synonyms such as oxidants, reactive oxygen species (ROS), oxidative stress, exercise, physical training, aerobic exercise, and strength exercise until 2019. This study selected a total of 18 articles for assessing the oxidative damage using various parameters such as malondialdehyde (MDA), protein carbonyl (PCO), and F1-isoprostanes and enzymatic antioxidants. We observed that any type of exercise can increase the oxidative damage in an exercise type and intensity manner. Further, the training status of the individual and specific oxidative damage marker plays a crucial role in predicting earlier oxidative damage in the exercise condition. However, some of the studies that we included for review did not perform follow-up evaluations. Therefore, follow-up programs using larger numbers need to be performed to confirm our findings.
DOI : https://doi.org/10.1155/2021/1947928
Cilt: 2021
ISSN: 2314-6133
Sınıflandırma :
22
Prognostic value of radial peripapillary capillary density for visual field outcomes in pituitary adenoma: A case-control study
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Clinical Neuroscience
Yayıncı:
Elsevier BV
Yazar(lar) :
Yang Tang , Wang Jia , Zhan Xue , Linhao Yuan , Yuanzhen Qu , Liu Yang , Lina Wang , Xiaochen Ma , Meizi Wang , Lei Meng , Kun Lei , Wen Lu , Xiaoyan Peng
Yıl :
2022
Meizi Wang
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DOI : 10.1016/j.jocn.2022.04.012
ISSN: 0967-5868
Cilt: 100
Sayfa: 113-119

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