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Update on the use of topical calcineurin inhibitors in cutaneous lupus erythematosus
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Biologics : Targets & Therapy
Yazar(lar) :
Michael Sticherling
Yıl :
2011
Michael Sticherling
Kaydet Alıntıla
Michael SticherlingHautklinik, Universitätsklinikum Erlangen (Clinic of Dermatology, University Hospitals of Erlangen), Erlangen, GermanyAbstract: Cutaneous manifestations of lupus erythematosus (CLE) are manifold, presenting with unspecific skin manifestations or well-defined clinical dermatological entities. Their relation to each other as well as to systemic lupus erythematosus is variable, yet diagnostically and therapeutically challenging. Therapeutic decisions have to be based on the activity and distribution as well as the type of skin lesions and the extent of systemic disease. Limited skin manifestations may be amply tackled by topical therapy, so far, mainly relying on corticosteroids. In many cases, however, internal treatment has to be combined by using antimalarials, in addition to strict UV-protection. The advent of topical calcineurin inhibitors has contributed substantially to the armamentarium of external treatment options. By specifically interfering with intracytoplasmic signal transduction to activate the nuclear factor of activated T-cells (NF-AT), they are able to modulate various inflammatory mechanisms. The two available compounds, pimecrolimus and tacrolimus, do not induce the skin atrophy characteristic of corticosteroids. They have been studied in a number of case reports, but only in a few randomized, comparative studies. Both are well-tolerated, but differentially effective in the various subsets of CLE. Further studies are needed to directly compare the two compounds to each other, as well as to topical corticosteroids, before final recommendations can be made.Keywords: cutaneous lupus erythematosus, calcineurin inhibitors, topical therapy, systemic therapy 
Cilt: 2011
Sayı: default
Sayfa: 21 - 31
Sınıflandırma :
2
Treatment of Autoimmune Disorders
e-Kitap

e-Kitap
Kaynak :
Internet Archive Books
Dergi:
Vienna : Springer Vienna : Imprint : Springer
Yayıncı:
Vienna : Springer Vienna : Imprint : Springer
Yazar(lar) :
Michael Sticherling
Yıl :
2003
Michael Sticherling
Yayıncı Web Sitesi
Kaydet Alıntıla
1 online resource (IX, 175 pages 32 illustrations) Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting Forword -- Preface -- Definitive T Cell epitope mapping for human disease: gluten challenge in coeliac disease identifies dominant transglutaminase-deamidated T Cell epitope -- On the extrapolation from animal models to human disease for the design of immunotherapy in autoimmune diabetes -- Use of olfactory ensheathing cells as candidates for transplant-mediated repair of central nervous system lesions -- Advances in understanding and use of autoantibodies as markers of diseases -- Leflunomide therapy for autoimmune diseases -- Immunotherapy for ocular inflammatory disease -- Advances in immunosuppressive treatment of juvenile idiopathic arthritis -- Significance of gamma-delta T lymphocytes in autoimmune diseases -- Treatment of autoimmune diseases by target DNA vaccines encoding pro-inflammatory mediators -- Immunosuppressive treatment of rheumatic diseases during pregnancy -- Persistence of maternal and fetal cells in autoimmune diseases -- Therapeutic aspects of autoimmune diseases of the skin -- Long term effects of T Cell vaccination in multiple sclerosis -- Plasmid-mediated delivery of antigens or biological response modifiers as means to suppress autoimmunity -- Intravenous immunoglobulins for the treatment of childhood autoimmune diseases Includes bibliographical references
Sayfa sayısı :202
Sınıflandırma :
3
Sklerosierende Hauterkrankungen
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Der Internist
Yazar(lar) :
Michael Sticherling
Konu :
Internal Medicine
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Sklerosierende Hautveränderungen sind eher Symptom als Diagnose und müssen daher sorgfältig abgeklärt werden. Die systemische Sklerodermie als Multiorganerkrankung ist von der zirkumskripten Sklerodermie zu trennen, da sie neben einem unterschiedlichen klinischen Bild eine unterschiedliche Prognose hat und ein anderes therapeutisches Vorgehen erfordert. Seltenere sklerosierende Hauterkrankungen mit Implikationen für die innere Medizin, die im vorliegenden Beitrag besprochen werden, sind die eosinophile Fasziitis, das Scleroedema adultorum Buschke, das Skleromyxödem und die nephrogene Fibrose.
DOI : 10.1007/s00108-019-0643-2
Anahtar Kelimeler : Systemische Sklerodermie, Morphea, Mischkollagenose, Skleromyxödem, Scleroedema adultorum, Systemic scleroderma, Morphea, Mixed connective tissue disease, Scleromyxedema, Scleredema adultorum
ISSN: 0020-9554 1432-1289
Sayı: 8
Cilt: 60
Sayfa: 783-791
4
Mechanisms of psoriasis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Drug Discovery Today: Disease Mechanisms
Yayıncı:
Elsevier
Yazar(lar) :
Michael Sticherling
Yıl :
2005
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Psoriasis represents one of the most common chronic inflammatory diseases of the human skin. Recent progress in studying its pathogenesis has provided targeted pharmacological strategies, which allow treatment with modest side effects, yet good clinical responses. However, both our current pathogenetic knowledge and therapy do not explain or amply tackle the clinically different subsets of psoriaisis and the gross intra- and inter-individual differences of disease manifestation.
DOI : 10.1016/j.ddmec.2005.05.019
ISSN: 1740-6765
Sayı: 2
Cilt: 2
Sayfa: 275-281
Sınıflandırma :
5
Psoriasis and autoimmunity
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Autoimmunity Reviews
Yayıncı:
Elsevier
Yazar(lar) :
Michael Sticherling
Yıl :
2016
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Psoriasis is one of the most common chronic inflammatory human skin diseases. Though clinically well characterized, the exact etiological and pathogenic mechanisms are still not known in detail. Current knowledge indicates distinct overlap to other inflammatory as well as autoimmune disorders. However, the one or more relevant autoantigens could not be characterized so-far. On the other side, several autoimmune diseases were shown to be associated with psoriasis. In addition, serological autoimmune phenomena, namely diverse circulating specific autoantibodies could be demonstrated in the past. A matter of current debate is if psoriasis is a primary autoimmune disease or secondarily evolving into autoimmunity as seen in other chronic inflammatory diseases. Related to this aspect is the concept of autoinflammation versus autoimmunity where psoriasis shares mechanisms of both entities. Though T-cells remain among the most important cellular players in the pathogenesis of psoriasis and current therapeutic strategies successfully target these cells or their products irrespective of these concepts, autoimmunity if relevant will add to the treatment armamentarium by using protective and prophylactic antigen-specific modalities.
DOI : 10.1016/j.autrev.2016.09.004
ISSN: 1568-9972
Sayı: 12
Cilt: 15
Sayfa: 1167-1170
Sınıflandırma :
6
Hauttumoren bei Älteren richtig differenzieren
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Geriatrie-Report
Yazar(lar) :
Michael Sticherling
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s42090-019-0204-9
ISSN: 1862-5363 2520-8950
Sayı: 1
Cilt: 14
Sayfa: 36-40
7
Multiple Dermal Abscesses by Trichophyton rubrum in an Immunocompromised Patient
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Medicine
Yazar(lar) :
Frédéric Toussaint , Michael Sticherling
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
We report the case of a 52-year-old man who presented with a 10 year history of multiple nodules with purulent drainage on the upper extremities. Several attempts of treatment with oral antibiotics had been unsuccessful. A skin biopsy specimen showed a dermal abscess with branched septate hyphae. A mycological culture of pus and of the biopsy specimen revealed Trichophyton rubrum. Deeper dermatophytosis presenting as dermal abscesses is a rare disease which occurs normally in immunocompromised conditions. Our patient was on immunosuppressive therapy with methylprednisolone and azathioprine because of inflammatory demyelinating polyneuropathy and presented with extensive abscesses. In cases of dermal abscesses it is important to not only consider bacterial but also fungal infections as underlying cause.
DOI : 10.3389/fmed.2019.00097
Anahtar Kelimeler : dermatophytosis, abscess, Trichophyton rubrum, immunosuppression, fungal infection
ISSN: 2296-858X
Cilt: 6
Sınıflandırma :
8
Impfungen in aller Munde – Relevanz auch für die Dermatologie?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Der Hautarzt
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2021
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s00105-020-04754-5
ISSN: 0017-8470 1432-1173
Sayı: 2
Cilt: 72
Sayfa: 91-91
9
Malignomrisiko erfordert enges Monitoring
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
hautnah dermatologie
Yazar(lar) :
Michael Sticherling
Yıl :
2017
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s15012-017-2308-y
ISSN: 0938-0221 2196-6451
Sayı: S1
Cilt: 33
Sayfa: 34-39
10
Reisen mit chronischen Dermatosen
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
hautnah dermatologie
Yazar(lar) :
Michael Sticherling
Yıl :
2016
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s15012-016-2228-2
ISSN: 0938-0221 2196-6451
Sayı: 5
Cilt: 32
Sayfa: 30-35
11
50/w mit kälteabhängiger, anfallsweiser Weißverfärbung einzelner Finger
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Der Hautarzt
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/s00105-019-4370-3
Anahtar Kelimeler : Hautsklerose, Antinukleäre Antikörper, Raynaud-Phänomen, Lungenfibrose, Pulmonale arterielle Hypertonie
ISSN: 0017-8470 1432-1173
Sayı: S1
Cilt: 70
Sayfa: 93-96
12
Systemische Sklerodermie - Fokus auf dermatologischen Aspekten. Teil 2: Diagnostik, Therapie
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2012
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/j.1610-0387.2012.07998_suppl.x
ISSN: 1610-0379
Sayı: 11
Cilt: 10
Sayfa: 783-791
13
Systemic sclerosis - focus on dermatological aspects. Part 2: Diagnostics, therapy
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2012
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/j.1610-0387.2012.07998.x
ISSN: 1610-0379
Sayı: 11
Cilt: 10
Sayfa: 783-791
14
Systemische Sklerodermie – die dermatologische Sicht
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Die systemische Sklerodermie oder Systemsklerose gehört in die Gruppe der entzündlichen Bindegewebserkrankungen und tritt im Wesentlichen mit zwei unterschiedlichen Verläufen, der akral limitierten und der diffusen Sklerodermie, auf. Beide sind durch eine Raynaud‐Symptomatik, eine anfallsweise Weißverfärbung der Akren, charakterisiert. Der Verlauf der diffusen Sklerodermie ist jedoch wesentlich schneller und geht mit einer frühzeitigen und prognosebestimmenden Organbeteiligung einher. Die ursachenorientierte Therapie der Erkrankung ist schwierig und beruht neben allgemeinen Maßnahmen der Lebensführung auf einer Verbesserung der rheologischen Situation sowie dem Einsatz von Immunmodulatoren und Immunsuppressiva, deren Effekte jedoch allenfalls krankheitsverlangsamend sind.
DOI : 10.1111/ddg.13887_g
ISSN: 1610-0379
Sayı: 7
Cilt: 17
Sayfa: 716-729
15
Systemische Sklerodermie - Fokus dermatologischer Aspekte. Teil 1: Pathogenese, Epidemiologie, klinisches Bild
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2012
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/j.1610-0387.2012.07999_suppl.x
ISSN: 1610-0379
Sayı: 10
Cilt: 10
Sayfa: 705-718
16
Systemic sclerosis – the dermatological perspective
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2019
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Systemic scleroderma/systemic sclerosis (SSc) is an inflammatory connective tissue disease clinically characterized by two major subtypes: limited and diffuse SSc. While both conditions present with Raynaud's phenomenon (paroxysmal digital ischemia), diffuse SSc is associated with rapid disease progression and early – prognostically relevant – involvement of internal organs. Treatment is challenging. In addition to general lifestyle modifications, measures include treatments aimed at improving circulation as well as immunosuppressive and immunomodulatory drugs. However, these agents are effective only in terms of slowing disease progression.
DOI : 10.1111/ddg.13887
ISSN: 1610-0379
Sayı: 7
Cilt: 17
Sayfa: 716-728
17
Systemic sclerosis - dermatological aspects. Part 1: Pathogenesis, epidemiology, clinical findings
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Michael Sticherling
Konu :
Dermatology
Yıl :
2012
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Systemic sclerosis is a chronic inflammatory multiorgan disease belonging to the group of collagen‐vascular disorders. With a prevalence of 10/100,000 inhabitants it may be regarded a rather rare disease. Its etiology and pathogenesis have still not been elucidated in detail, especially with regard to the differential involvement of skin and the cause of the clinically heterogeneous disease courses. Various components of the vasculature, connective tissue as well as the immune system are involved in a yet unknown sequence and significance. Patients need to be cared for in an interdisciplinary fashion depending on the individual organ involvement. Apart from the skin, the heart, kidneys and lungs are mainly affected in addition to frequent gastrointestinal and musculoskeletal symptoms. Clinically two distinct subsets may be separated, acral (also termed limited) and diffuse scleroderma, which are characterized by anti‐centromere and anti‐Scl‐70/topoisomerase‐1 antibodies, respectively. Recent data demonstrate a poor prognosis even in limited disease when pulmonary arterial hypertension develops at an early stage. In diffuse disease sudden and rapid onset will result in a sclerosis of major internal organs and early death in many cases.
DOI : 10.1111/j.1610-0387.2012.07999.x
ISSN: 1610-0379
Sayı: 10
Cilt: 10
Sayfa: 705-716
18
Alcohol: intolerance syndromes, urticarial and anaphylactoid reactions
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Clinics in Dermatology
Yayıncı:
Elsevier
Yazar(lar) :
Michael Sticherling , Jochen Brasch
Yıl :
1999
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/s0738-081x(99)00027-9
ISSN: 0738-081X
Sayı: 4
Cilt: 17
Sayfa: 417-422
Sınıflandırma :
19
Autoimmune blistering diseases of the skin
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Autoimmunity Reviews
Yayıncı:
Elsevier
Yazar(lar) :
Michael Sticherling , Cornelia Erfurt-Berge
Yıl :
2012
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Autoimmune skin diseases represent a heterogeneous group of disorders with grossly diverging clinical manifestations but partly shared underlying immunological mechanisms. They may affect the skin as an isolated organ or among systemic diseases. In addition unspecific cutaneous symptoms or drug-induced unwanted effects can be seen and have to be carefully dissected from an exacerbations of the underlying disease. Growing pathogenic knowledge has elucidated serological and clinical pictures heterogeneity and at the same time increased the therapeutic armentarium for these partly life-threatening diseases. In this review, the focus is on autoimmune bullous diseases with the skin as the major target which involve antigens of epidermis, basal membrane or dermis. Among these the pemphigoid and pemphigus group may be differentiated from dermatitis herpetiformis Duhring and epidermolysis bullosa acquisita. Interestingly, pathogenetically relevant antibody responses of IgA subtype can be found in any of the first three groups. Their clinical picture as well as therapeutic response are distinctly different from the other mainly IgG mediated subsets. Though systemic corticosteroids are still the mainstay of therapy, differential approaches using diverse adjuvant drugs are available. Immunoserological data may help characterize subsets and monitor clinical diseases as well as therapeutic response.
DOI : 10.1016/j.autrev.2011.05.017
ISSN: 1568-9972
Sayı: 3
Cilt: 11
Sayfa: 226-230
Sınıflandırma :
20
The collection of dermatologic wax moulages at the University of Kiel, Germany
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Michael Sticherling , Uta Euler
Konu :
Dermatology
Yıl :
2001
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1046/j.1365-4362.2001.01268.x
ISSN: 0011-9059
Sayı: 9
Cilt: 40
Sayfa: 586-592
21
Familiares Auftreten einer segmentalen Typ-2-Manifestation der kutanen Leiomyomatose. Familial occurrence of a type 2 segmental manifestation of cutaneous leiomyomatosis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
Journal der Deutschen Dermatologischen Gesellschaft
Yazar(lar) :
Regina Renner , Michael Sticherling
Konu :
Dermatology
Yıl :
2005
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Hintergrund: Es ist eine Reihe von malignen und benignen Hautkrankheiten beschrieben, bei denen Mosaizismen oder segmentale Ausprägungen auftreten können, z. B. die segmentale Neurofibromatose 1 oder die kutane Leiomyomatose. Insbesondere bei segmentalen Manifestationen von Hauterkrankungen ist ein Verlust der Heterozygotie für die Entstehung bedeutsam. Zwei Ausprägungen einer segmentalen Manifestation können bei autosomal‐dominant vererbten Hauterkrankungen wie der kutanen Leiomyomatosis definiert werden. Der Typ 1 entsteht durch postzygotische segmentale Neumutation, der Typ 2 zeigt sich bei einem zusätzlichen postzygotischen Verlust der Heterozygotie bei einem bereits heterozygoten Embryo. Der Verlust der Heterozygotie ist ein genetischer Vorgang, bei dem eine für ein Merkmal heterozygote Zelle entweder homozygot oder hemizygot wird, indem das entsprechende Wildtyp‐Allel verloren geht. Dieses Phänomen kann als eine Vorbedingung für Tumorwachstum angesehen werden. Beim Typ 2 ist der segmentale Befall oftmals ausgeprägter mit zusätzlich disseminiertem Hautbefall, da eine Keimbahnmutation mit Heterozygotie aller somatischen Zellen außerhalb des stark betroffenen Areals vorliegt.
DOI : 10.1111/j.1610-0387.2005.05742.x
ISSN: 1610-0379
Sayı: 9
Cilt: 3
Sayfa: 695-699
22
Das „Sterben” der Moulagen - Wachsabbildungen in der Dermatologie
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Der Hautarzt
Yazar(lar) :
Michael Sticherling , Uta Euler
Konu :
Dermatology
Yıl :
1999
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Die künstlerische Verwendung von Wachs geht auf eine lange Tradition bis ins Altertum zurück. Seit der Renaissance fand die medizinisch exakte bildnerische Darstellung der menschlichen Anatomie sowie verschiedener Erkrankungen in Wachs breite Anwendung. In der Mitte des letzten Jahrhunderts bildete sich dabei die Moulagenkunst mit naturgetreuen, dreidimensionalen Abbildungen von erkrankten menschlichen Körperteilen aus und fand große Verbreitung in der Dermatologie. Ihre Blüte und weite Verbreitung laufen dabei der zunehmenden Eigenständigkeit des Faches parallel. Zahlreiche regional und überregional tätige Moulageure haben jedoch bis auf wenige Ausnahmen keine Schüler hinterlassen und ihre Moulagentechnik der Nachwelt nicht zugänglich gemacht. Auch die Kieler Universitätshautklinik verfügt aus dieser Zeit über eine umfangreiche Moulagensammlung. Die heute verbliebenen 455 Objekte gehen auf Professor Viktor Felix Karl Klingmüller (1870–1942) zurück, der von 1906 bis 1937 Direktor der Hautklinik war. Der Breslauer Moulageur Alfons Kröner (gest. 1937) stellt mit 354 Moulagen den bis heute größten Anteil der Sammlung. Als zu seiner Zeit hoch geschätzter und sehr produktiver Künstler galt er in Hinsicht auf seine Moulagentechnik als sehr verschlossen. 35 seiner Kieler Moulagen tragen die Abkürzung „DRP”, deren Bedeutung als „Deutsches Reichspatent” jetzt bestätigt werden konnte. Danach hat Kröner 1902 ein Patent erhalten und beschreibt darin detailliert seine Wachszusammensetzung und den technischen Ablauf der Moulagenherstellung. Ähnlich wie Jules Baretta (Paris) benutzte er demnach eine Untermaltechnik zum Kolorieren der Wachspositive. Die Beantragung eines Patentes belegt den Versuch, angesichts des Konkurrenzdruckes und der zunehmenden Kommerzialisierung unter den Lehrmittelherstellern seiner Zeit zu bestehen. Darüber hinaus ist auch die Kenntnis dieser Technik von medizinhistorischem Interesse, andererseits für die Restauration der in unterschiedlichem Ausmaß alternden Wachsobjekte wesentlich. Moulagen können aber auch heute noch angesichts ihrer dreidimensionalen Darstellung und Wirklichkeitsnähe gegenüber modernen Abbildungsverfahren bestehen. Das „Sterben” der Wachsobjekte selbst als auch des Interesses an ihnen sollte daher aufgehalten werden.
DOI : 10.1007/s001050050980
Anahtar Kelimeler : Schlüsselwörter Dermatologische Moulagen, Patentschrift, Kröner, Klingmüller, Kiel, Untermaltechnik, Key words Dermatological moulages, Grand of patent, Kröner, Klingmüller, Kiel, Background painting
ISSN: 0017-8470 1432-1173
Sayı: 9
Cilt: 50
Sayfa: 674-678
23
Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Anke Suess , Michael Sticherling
Konu :
Dermatology
Yıl :
2007
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Background Subacute cutaneous lupus erythematosus (SCLE), a distinct clinical subset of lupus erythematosus, remains a therapeutic challenge, especially in cases resistant to topical and standard systemic therapy. Leflunomide, a novel antirheumatic drug, has shown efficacy in the treatment of systemic lupus erythematosus in pilot studies.
DOI : 10.1111/j.1365-4632.2007.03333.x
ISSN: 0011-9059
Sayı: 1
Cilt: 47
Sayfa: 83-86
24
COVID-19: risk for cytokine targeting in chronic inflammatory diseases?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Springer Nature
Dergi:
Nature Reviews Immunology
Yayıncı:
Springer Nature
Yazar(lar) :
Georg Schett , Michael Sticherling , Markus F. Neurath
Konu :
SARS-CoV-2
Yıl :
2020
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
COVID-19, caused by the SARS-CoV-2 virus, has become pandemic. With sharply rising infection rates, patient groups characterized by an enhanced infection risk will be challenged by the virus. In this context, patients with chronic immune-mediated inflammatory diseases are of particular interest, as these diseases are characterized by an intrinsic immune dysfunction leading to inflammation that may enhance risk for severe infection. Immune-mediated inflammatory diseases are often treated with cytokine blocking therapy. This comment discusses whether such therapies may pose a risk — or even a benefit — in the context of the current COVID-19 pandemic.
DOI : 10.1038/s41577-020-0312-7
ISSN: 1474-1741
Cilt: 20
Sayı: 5
Sayfa: 271-272
Sınıflandırma :
Viroloji %38
25
Uncommon Presentation of Scleromyxoedema with a Distribution Pattern Mimicking a Photodermatosis
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Acta Dermato-Venereologica
Yazar(lar) :
Michael Constantin Kirchberger , Michael Sticherling , Michael Erdmann
Yıl :
2017
Michael Sticherling
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.2340/00015555-2684
Cilt: 97
Sayı: 8
Sayfa: 979 - 980
Sınıflandırma :
26
Concomitant psoriasis and bullous pemphigoid: coincidence or pathogenic relationship?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Agnes Wilczek , Michael Sticherling
Konu :
Dermatology
Yıl :
2006
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Psoriasis vulgaris and bullous pemphigoid represent two clinically well‐characterized, chronic, inflammatory skin diseases. The concomitant occurrence of these two entities in a patient is rare, and the pathogenic implications of this phenomenon are unknown. We describe a 55‐year‐old woman with a 25‐year history of plaque‐type psoriasis who presented with disseminated tense bullae. Skin biopsies showed the typical histologic and immunohistochemical traits of bullous pemphigoid, and she had circulating immunoglobulin G (IgG) antibodies against the basement membrane zone, specifically the BP180 antigen. The bullous eruption was successfully treated with oral methylprednisolone and dapsone.
DOI : 10.1111/j.1365-4632.2006.02861.x
ISSN: 0011-9059
Sayı: 11
Cilt: 45
Sayfa: 1353-1357
27
Sister Mary Joseph's nodule as a metastasis of gallbladder carcinoma
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Regina Renner , Michael Sticherling
Konu :
Dermatology
Yıl :
2007
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Umbilical metastasis, alias Sister Mary Joseph's nodule, is a rare clinical phenomenon. It indicates neoplasm of inner organs mostly located in the gastrointestinum or the pelvis. However, in approximately 15–30% the primary tumor remains occult. In most cases Sister Joseph's nodule appears as an early and sometimes the only symptom of the malignoma. Here we report on an umbilical metastasis of a gallbladder carcinoma with subsequent manifestation of other tumor complications such as extensive thrombosis of arm veins.
DOI : 10.1111/j.1365-4632.2006.03046.x
ISSN: 0011-9059
Sayı: 5
Cilt: 46
Sayfa: 505-507
28
Epidermolysis bullosa acquisita und neuroendokrines Pankreaskarzinom – Koinzidenz oder pathogenetischer Zusammenhang?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Yazar(lar) :
Jan-Ole Busch , Michael Sticherling
Konu :
Dermatology
Yıl :
2007
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1111/j.1610-0387.2007.06338_supp.x
ISSN: 1610-0379
Sayı: 10
Cilt: 5
Sayfa: ---
29
Panarteritis cutanea benigna ? an entity limited to the skin or cutaneous presentation of a systemic necrotizing vasculitis? Report of seven cases and review of the literature
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
International Journal of Dermatology
Yazar(lar) :
Christina Rogalski , Michael Sticherling
Konu :
Dermatology
Yıl :
2007
Michael Sticherling
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Objective In 1931 Lindberg described a limited and benign subcutaneous form of panarteritis nodosa, which, in contrast to systemic panarteritis, only affects the skin. The terms panarteritis nodosa cutanea benigna, cutaneous polyarteritis nodosa, apoplexia cutanea Freund as well as livedo with nodules are used synonymously for this vasculitis which predominantly affects women in the fifth decade of life. Cutaneous lesions characteristically comprise painful subcutaneous nodules or vasculitis racemosa at the lower extremities. The cutaneous panarteritis may be regarded as its own entity or an isolated skin manifestation within systemic panarteritis nodosa.
DOI : 10.1111/j.1365-4632.2007.02975.x
ISSN: 0011-9059
Sayı: 8
Cilt: 46
Sayfa: 817-821

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