Many years of experience in the use of homeopathic medicines in the treatment and prevention of respiratory diseases has been accumulated in Russia; it testifies to the effectiveness of their use in pediatrics.Materials and methods. The results of a multicenter open randomized observation on the effectiveness of the homeopathic medicine Oscillococcinum® in the treatment of influenza and other acute respiratory diseases in children aged 6 to 12 years are presented.Results. It was shown that short-term (within 4 days from the onset of the disease) administration of the drug according to the standard scheme leads to a persistent improvement in clinical symptoms already on the 4th day of illness in most children (88.66%). Symptoms of intoxication, such as weakness, headache, temperature reaction are recorded by the 14th day of the disease in only 2—4% of cases. Catarrhal symptoms stop by the end of the second week of the disease in most children. Only 1 adverse event was identified associated with the course of the underlying disease.
30 января 2020 года Всемирная Организация Здравоохранения (ВОЗ) признала вспышку коронавирусной инфекции в Китае чрезвычайной ситуацией в области общественного здравоохранения, имеющую международное значение. Генеральный директор ВОЗ Тедрос Адханом Гебрейесус после совещания чрезвычайного комитета в Женеве заявил «Я объявляю международную чрезвычайную ситуацию в области общественного здравоохранения из-за глобальной вспышки коронавируса». В классификации ВОЗ такими ситуациями считаются «экстраординарные события, которые будут представлять риск в области здравоохранения другим государствам» и потенциально требуют скоординированных действий международного сообщества. Как говорится в заявлении ВОЗ, распространение вируса возможно остановить, если страны мира примут меры по раннему распознаванию коронавируса, изолируют больных и отследят контакты.
Vaccine is essentially the only measure by which there is a real opportunity to eliminate an infectious disease. And the flu is no exception. The high variability of influenza virus A/H1N1, which causes a pandemic, and most epidemics, is the problem of creating effective etiotropic treatments and vaccines. The emergence of new vaccine manufacturing technologies, such as genetic engineering, DNA technology, allows for a fresh look at the problem of influenza eradication on the planet. Universal year-round mass vaccination against influenza, not just high-risk groups, should be included in all national vaccination program, but this strategy will help stop influenza infection.
Vaccination is crucial in maintaining the health of the nation. Achieved outstanding successes in the fight against childhood infections. The article shows the prospects of using the method of vaccination including the treatment and prevention of dysbiotic disorders, for the treatment and prevention of immune disorders, the chronicity of the process, increase of immune response. Described tactic vaccination of various population groups.
DOI : 10.22627/2072-8107-2015-14-4-6-12 Anahtar Kelimeler :
vaccinal prevention, immunorehabilitation, quality of life
ISSN: 2072-8107 Cilt: 14 Sayı: 4 Sayfa: 6 - 12
A new value was acquired by the drug Orvirem®, which is a combination of rimantadine and natrium alginate. In recent years, it has not been recommended for use due to the resistance to it strains of the influenza A(H1N1) virus pdm2009. Currently, this drug has acquired a new meaning, and this is due to the dominance of subtype A(H3N2). Two recent clinical studies have demonstrated that the drug Orvirem® has proven activity against viruses not only of influenza A but also B, coronavirus, and other common pathogens of respiratory viral infections (rhinoviruses, respiratory syncytial virus, adenovirus, etc.). High efficacy, safety and absence of adverse reactions make it possible to widely use Orvirem® in children from the first year of life, incl. with chronic diseases.
Acute infectious diarrheal diseases by the terminology of the World Health Organization or acute intestinal infections (AII) as they are called in Russia is a large group of acute infectious diseases characterized by development in patient of the diarrheal syndrome. The article provides statistical data on the incidence rate of AII among children that take one of the leading places in the structure of the infectious pathology and characterizing by the high mortality rate. Special attention is given to pathogenesis and therapy of acute viral intestinal diseases.
The article presents the results of many, including the blind, randomized, placebo-controlled studies of domestic antiviral drug Kagocel® obtained by chemical synthesis from the sodium salt of carboxymethyl cellulose and low-molecular weight polyphenol natural vegetable origin (cotton). The main mechanism of action of the drug is its ability to induce the production of interferons, and more specifically, the late-interferons, whose peak activity is reached after 18-24 hours after the conduct of the inductor. It is shown that the drug can be used in adults and children, not only in the treatment of influenza and acute respiratory viral infections, including proceeding with complications (obstructive laryngitis and BOS syndrome, lacunar angina, etc..), but also in viral lesions of the gastrointestinal tract rotavirus and norovirus etiology and affect the rate of elimination of the viruses.
The article presents data on the design of different influenza vaccines, as well as safety, immunogenicity and efficacy of a new national preventive virosomal? vaccine ULTRIKS®. It is shown that the vaccine is high-immunogenic preventive medications and may be recommended for annual preventive vaccination of children and adults against influenza, primarily of persons at higher risk of infection and the incidence of influenza and SARS, people older than 60 years, and persons with secondary immunodeficiency states.
The analysis of the scientific literature and the results of clinical studies on the safety and efficacy of using for respiratory infections components of plant origin and bee products included in the composition of biologically active food supplements — «Propolis with Herbs» marmalade, throat lollipop with honey and Althaea night syrup with honey-line INVAR KIDS. It has been shown that the use of herbal remedies that contain components with established clinical safety and proven efficacy as a symptomatic therapy is reasonable for alleviating the main symptoms of respiratory diseases in children.
We observed 50 children aged 3 to 15 years, admitted to hospital with a diagnosis of acute respiratory disease, occurring in all children with clinical manifestations of acute tonsillopharyngitis, half of the children — with symptoms of rhinitis and laryngotracheitis, tracheobronchitis and bronchitis. In the group of children receiving hexetidine (25) had a significantly faster compared to the control group (25), reducing the duration of symptoms such as redness and pain in the throat. The presence of hexetidine antiviral and antibacterial activity allows the physician to refrain from the immediate purpose of the course of antibiotic therapy, and allows time for her studies.
Anaferon — antiviral drug with immunomodulating activity. Longstanding experience proved its efficacy and safety in the treatment and prophylaxis of a wide spectrum of viral and bacterial infections in children. The key mechanisms of anaferon action are selective induction of interferons I and II types production and allosteric modulation of interferon-gamma receptor. Excellent safety profile, possibility of its combination with other medicines, absence of self-tapering have made it a drug of choice for the treatment and prophylaxis of various infections of different aetiology.
DOI : 10.22627/2072-8107-2013-12-3-24-29 Anahtar Kelimeler :
anaferon, interferon inducer, treatment and prevention of ard, children
ISSN: 2072-8107 Cilt: 12 Sayı: 3 Sayfa: 24 - 29
Polyoxidonium® — domestic drug with a broad spectrum of pharmacological action, which is unparalleled in the world. The drug is used as an immunomodulator, detoksikant, immunostimulatory and sustained release carrier of pharmacologically active compounds. Currently collected convincing evidence base safe and effective use Polyoxidonium for respiratory diseases with severe severity of symptoms, including in children with a poor premorbid background (often ill children, chronic lymph adenotonzillit pathology of allergic disease), are at risk of complicated infection (ARI suppurative complications in history), the formation of prevention programs and immunoreabilitatsionnyh children with recurrent respiratory infections.
Clinical effectiveness and safety of topical immunomodulator IRS 19 in treatment and prophylaxis of infectious diseases of airways in adults and children was studied in numerous Russian clinical studies. The article reviews the most interesting results of these studies. Administration of bacterial lysates mixture lowers the rate of acute respiratory infections (ARI) and exacerbations of chronic ENT diseases in patients including frequently ailing children. Treatment with the drug results in much smoother disease’s course. Action of a drug shortens terms of a disease, induces significant decrease of ARI complications rate, normalization of nasopharinx biocenose, and lowers the need in antibacterial drugs.
The article presents incidence rates of major vaccine-preventable diseases in the world and the Russian Federation and cites mitigation measures that, in the end, must lead to the elimination of the diseases.
The results of application of the drug of natural origin (Aflubin) with immunomodulating, anti-inflammatory, detoxifying effect in complex treatment of influenza and acute respiratory infections in children are presented. The inclusion of Aflubin in the complex treatment of diseases contributed to reducing the severity and duration of intoxication, reducing the duration of catarrhal phenomena, preventing the development of secondary bacterial complications. Relative simplicity of the drug (drops) at affordable cost, therapeutic and preventive efficacy in all age groups ensure its high compliance.
DOI : 10.22627/2072-8107-2017-16-4-63-66 Anahtar Kelimeler :
drug of natural origin (aflubin), influenza, acute respiratory infections, children
ISSN: 2072-8107 Cilt: 16 Sayı: 4 Sayfa: 63 - 66
The article describes the results of clinical diagnostic methods for risk assessment childbirth with intrauterine infection, data from clinical trials with a high level of evidence efficacy VIFERON® in adjuvant therapy in preterm infants with severe intrauterine viral infections.
The article presents the changes Immunization Schedule Russia introduced in 2014. In new Schedule now is the vaccination against pneumococcal disease for all children of 2 months with revaccination at 4 and 15 months old; excluded from the Schedule second revaccination against tuberculosis. At risk groups to be vaccinated against the flu, entered pregnant women and persons subject to military conscription. Recommendations on use of vaccines containing relevant antigens for the Russian Federation, to provide maximum effectiveness of immunization and vaccines that do not contain preservatives in children under 1 year of age. Offered to create a council of experts in the field of vaccinology and vaccine prevention
DOI : 10.22627/2072-8107-2014-13-3-24-29 Anahtar Kelimeler :
russia calendar of immunization
ISSN: 2072-8107 Cilt: 13 Sayı: 3 Sayfa: 24 - 29
The article presents the results of studies of the effectiveness and safety of domestic antiviral drug Аrbidol in children. Arbidol demonstrated antiviral activity not only against influenza viruses, and other respiratory viruses (respiratory syncytial virus, parainfluenza, rhinovirus), coronavirus, rotavirus, and others.
The authors have investigated the level of lymphocyte subpopulation, immunoglobulins IgA, IgM, IgG and the concentration of 10 cytokines in blood serum of 67 sickly children. All of them have chronic somatic pathology. The authors have ascertained absence of significant differences in immunological indicators. When the level of subpopulation composition of lymphocytes and IgG, IgA, IgM in the blood serum is normal, such children have a higher concentration of antiphlogistic cytokines 1L-1β, IL-12p70, IL-8 whereas the balance of Th/Th2-cells is preserved. It is kept up by cytokines IL-2, IFN-γ, TNF-α, IL-4, IL-5, IL-10 inthe conditions of chronic inflammatory process. The maintenance of this balance is the main goal and it should provide the basis for immunological correction of sickly children with chronic somatic pathology. The most appropriate drug for immunological correction in our research is ribosomal immunоmodulator Ribomunyl.
Subpopulation of lymphocytes and the concentration level of 10 cytokines in serum were studied in 62 of 67 sickly children with chronic somatic diseases on the background of medical course the drug Ribomunyl. The tendency to reduction of cytokines , while maintaining balance of Th1/Th2 cells has been determined. It indicates beneficial effects of the drug Ribomunyl on the immune system, and homeostasis. Clinical efficacy of Ribomunyl is evident in the reduced number of acute respiratory diseases and, as a consequence, fewer exacerbations of chronic somatic diseases.
DOI : 10.22627/2072-8107-2013-12-4-39-42 Anahtar Kelimeler :
children with chronic somatic diseases, immunotherapy, ribomunyl
ISSN: 2072-8107 Cilt: 12 Sayı: 4 Sayfa: 39 - 42
The experience of Ribomunyl application in domestic pediatrics has shown its high preventive efficacy at respiratory infections, especially in sickly children with various somatic pathologies even in postvaccinal period. Peroral administration of Ribomunyl, its low toxicity, capability for creating cross-immunity to various serotypes of the pathogen, makes it indispensable in pediatric practice.
We estimated the safety of the vaccination for prevention of influenza with Grippol® plus vaccine alongside with vaccination with combined preparations for the prevention of diphtheria and tetanus (Td) and measles, rubella, mumps in children aged 6—7 years. We determined that combined immunization with the indicated vaccines proves good tolerability and low reactogenicity. Vaccine Grippol® Plus shows low reactogenicity , high immunologenicity and does not cause cross-suppression of antibodies in co-administration with other vaccines on vaccination calendar. Also concomitant vaccination with Grippol® plus and other vaccines does not inhibit the development of a specific immune response against influenza.
DOI : 10.22627/2072-8107-2013-12-1-14-17 Anahtar Kelimeler :
combined vaccination, vaccine for prevention of influenza, grippol® plus vaccine
ISSN: 2072-8107 Cilt: 12 Sayı: 1 Sayfa: 14 - 17
The article describes modern methods of teaching needed to ensure and improve the learning process, while maintaining traditional ways of learning. Character-ized by control methods to ensure the educational process, argues conducting educational monitoring and presents a contemporary view of the problem of quality of education in high school, in terms of its reform intensification of training in high school are invited to spend, using the elements of the educational process of constructive pedagogy.
DOI : 10.22627/2072-8107-2015-14-1-55-59 Anahtar Kelimeler :
intensification of the process of learning, constructive pedagogy, educational monitoring, quality of education
ISSN: 2072-8107 Cilt: 14 Sayı: 1 Sayfa: 55 - 59
In the study, safety for influenza vaccine in combination with diphtheria vaccine, tetanus and measles vaccine, rubella vaccine, and epidemic parotitis in children of 6–7 years old was assessed. All vaccines showed good tolerability and low reactogenicity for combined immunization. Influenza «Grippol plus» vaccine is safe and highly immunogenic, and does not cause cross antibody suppression being applied in combination with mentioned National Immunization Schedule vaccines.
In this paper the authors describe the features of professional continuous medical education in the modern conditions of higher education reform inRussia. A new role of the teacher of the medical school is described. It is important to be professionally competent and to master modern teaching technologies (educational modules, project learning methods, distant education, etc.). The system of continuous medical education as a tool of professional development should become a strategic objective in the implementation of the goals of reforming professional medical education inRussia.
DOI : 10.22627/2072-8107-2013-12-4-63-67 Anahtar Kelimeler :
professional continuous medical education, modern teaching innovative educational technology, professional competence of the teacher and medical professional
ISSN: 2072-8107 Cilt: 12 Sayı: 4 Sayfa: 63 - 67
Conceptual position of vocational education is the personal and professional development learning and personal development is an essential goal of vocational education. The formation and development of the specialist involves the development of a professional intelligence, independence, self-confidence, professionally important qualities and competence.
DOI : 10.22627/2072-8107-2016-15-1-64-67 Anahtar Kelimeler :
motivational activity, satisfaction with the work process, motivational sphere of personality
ISSN: 2072-8107 Cilt: 15 Sayı: 1 Sayfa: 64 - 67
The article presents the results of the study of clinical and epidemiological data from 2044 children aged under 18 years who were hospitalized with influenza and other ARVI in the epidemic season 2010/11. The effectiveness of conducted antiviral therapy was also evaluated. The most frequently prescribed antiviral drug at prehospital and hospital stages was Arbidol. It is shown that early appointment of Arbidol significantly reduced the duration of the main symptoms of influenza and acute respiratory viral infections, and the risk of complications.
The shift in priorities in the system of Russian education, transition from reproductive learning to learner-centered approach, incorporation of competency-based approach into the educational standards of «the third generation» require the training of a competitive specialist with professional competency. Types of competencies are characterized. The competency presenting certain requirements is studied. The mastering of the requirements will enable to train qualified specialists. The quality of education directly influences the level of professional activity through training of specialists and development of sciences. Competence-oriented approach and adherence to pedagogic requirements in education enables the efficacy of professional training. Innovative techniques and approaches to organizing educational process in their active form stimulate the process of studying.
DOI : 10.22627/2072-8107-2013-12-3-62-64 Anahtar Kelimeler :
competence, competency, innovative methods of education, professional training, competitive specialist, modernization of education
ISSN: 2072-8107 Cilt: 12 Sayı: 3 Sayfa: 62 - 64
The development of the modern education system includes a number of features. Learning involves a high level of independence with the leading role of the student. Vocational education institutions should provide a wide range of educational services that are adequate to labor market demands. Methods and forms of education should be variable including active use of modern educational technology as one of the most convenient ways of learning.
DOI : 10.22627/2072-8107-2013-12-2-59-61 Anahtar Kelimeler :
education technology, the bologna process, continuing professional education, the reform of medical education, competence
ISSN: 2072-8107 Cilt: 12 Sayı: 2 Sayfa: 59 - 61