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Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

International Journal of Molecular Sciences

Yazar(lar) :

Roberta Giordo , Gheyath K. Nasrallah , Ola Al-Jamal , Panagiotis Paliogiannis , Gianfranco Pintus

Yıl :

2020

Ola Al-Jamal

Yayıncı Web Siteleri

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. Oxidative stress is recognized as the primary trigger of NP-associated toxicity, suggesting antioxidants as a promising counteractive approach. Here, we investigated the protective effect of the natural antioxidant resveratrol against ZnO NP-induced toxicity in vivo using the zebrafish model. Our findings demonstrate that resveratrol counteracts ZnO NP-induced zebrafish lethality preventing cardiac morphological and functional damage. NP-induced vascular structural abnormalities during embryonic fish development were significantly counteracted by resveratrol treatment. Mechanistically, we further showed that resveratrol inhibits ROS increase, prevents mitochondrial membrane potential dysfunction, and counteracts cell apoptosis/necrosis elicited by ZnO NP. Overall, our data provide further evidence demonstrating the primary role of oxidative stress in NP-induced damage, and highlight new insights concerning the protective mechanism of antioxidants against nanomaterial toxicity.

Kaynak 1: https://doi.org/10.3390/ijms21113838 arayıcılığı görüntüle.
Kaynak 2: http://dx.doi.org/10.3390/ijms21113838 arayıcılığı görüntüle.

DOI : 10.3390/ijms21113838

Anahtar Kelimeler : resveratrol, nanoparticles, oxidative stress, antioxidants, mitochondria

Cilt: 21
Sayı: 3838
Sayfa: 3838

Sınıflandırma :

Biyotıp %99

Apoptoz %87

Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2

Dergi Makalesi

Kaynak 1:

Directory of Open Access Journals (DOAJ)

Kaynak 2:

MDPI

Dergi:

Viruses

Yazar(lar) :

Nadin Younes , Duaa W. Al-Sadeq , Hadeel AL-Jighefee , Salma Younes , Ola Al-Jamal , Hanin I. Daas , Hadi. M. Yassine , Gheyath K. Nasrallah

Yıl :

2020

Ola Al-Jamal

Yayıncı Web Siteleri

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Kaydet

The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. The past three unprecedented outbreaks of emerging human coronavirus infections at the beginning of the 21st century have highlighted the importance of readily available, accurate, and rapid diagnostic technologies to contain emerging and re-emerging pandemics. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) based assays performed on respiratory specimens remain the gold standard for COVID-19 diagnostics. However, point-of-care technologies and serologic immunoassays are rapidly emerging with high sensitivity and specificity as well. Even though excellent techniques are available for the diagnosis of symptomatic patients with COVID-19 in well-equipped laboratories; critical gaps still remain in screening asymptomatic people who are in the incubation phase of the virus, as well as in the accurate determination of live viral shedding during convalescence to inform decisions for ending isolation. This review article aims to discuss the currently available laboratory methods and surveillance technologies available for the detection of COVID-19, their performance characteristics and highlight the gaps in current diagnostic capacity, and finally, propose potential solutions. We also summarize the specifications of the majority of the available commercial kits (PCR, EIA, and POC) for laboratory diagnosis of COVID-19.

Kaynak 1: https://doi.org/10.3390/v12060582 arayıcılığı görüntüle.
Kaynak 2: http://dx.doi.org/10.3390/v12060582 arayıcılığı görüntüle.

DOI : 10.3390/v12060582

Anahtar Kelimeler : COVID-19, SARS-CoV-2, viruses, diagnostic challenges, molecular testing, serology

ISSN: 1999-4915
Cilt: 12
Sayı: 582
Sayfa: 582

Sınıflandırma :

Tıp ve Halk Sağlığı %87

Bulaşıcı Hastalıklar %93

Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO2 Photocatalytic Nanocomposites Using the Zebrafish Embryo Model

Dergi Makalesi

Kaynak 1:

MDPI

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Nanomaterials

Yayıncı:

MDPI AG

Yazar(lar) :

Halema Al-Kandari , Nadin Younes , Ola Al-Jamal , Zain Z. Zakaria , Huda Najjar , Farah Alserr , Gianfranco Pintus , Maha A. Al-Asmakh , Aboubakr M. Abdullah , Gheyath K. Nasrallah

Yıl :

2019

Ola Al-Jamal

Yayıncı Web Siteleri

Tam Metin

Özet Ek Bilgiler

Kaydet

Advanced oxidation processes (AOPs) have recently attracted great interest in water pollution management. Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen (H2RGOTi)-reduced graphene oxide/TiO2 semiconductor photocatalysts recently employed in AOPs. For this purpose, acutoxicity, cardiotoxicity, neurobehavioral toxicity, hematopoietic toxicity, and hatching rate were determinate. For the RGOTi, the no observed effect concentration (NOEC, mortality/teratogenicity score <20%) and the median lethal concentration (LC50) were <400 and 748.6 mg/L, respectively. H2RGOTi showed a NOEC similar to RGOTi. However, no significant mortality was detected at all concentrations used in the acutoxicity assay (up to1000 mg/L), thus indicating a hypothetical LC50 higher than 1000 mg/L. According to the Fish and Wildlife Service Acute Toxicity Rating Scale, RGOTi can be classified as “practically not toxic” and H2RGOTi as “relatively harmless”. However, both nanocomposites should be used with caution at concentration higher than the NOEC (400 mg/L), in particular RGOTi, which significantly (i) caused pericardial and yolk sac edema; (ii) decreased the hatching rate, locomotion, and hematopoietic activities; and (iii) affected the heart rate. Indeed, the aforementioned teratogenic phenotypes were less devastating in H2RGOTi-treated embryos, suggesting that the hydrogen-reduced graphene oxide/TiO2 photocatalysts may be more ecofriendly than the thermally-reduced ones.

Kaynak 1: http://dx.doi.org/10.3390/nano9040488 arayıcılığı görüntüle.
Kaynak 2: https://doi.org/10.3390/nano9040488 arayıcılığı görüntüle.

DOI : 10.3390/nano9040488

ISSN: 2079-4991
Sayı: 4
Cilt: 9
Sayfa: 488

Sınıflandırma :

Çevre %100

Çevresel Sağlık %63

Çevre %21

Organ-specific toxicity evaluation of stearamidopropyl dimethylamine (SAPDMA) surfactant using zebrafish embryos

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Science of The Total Environment

Yayıncı:

Elsevier

Yazar(lar) :

Ola Al-Jamal , Hadeel Al-Jighefee , Nadin Younes , Roba Abdin , Maha A. Al-Asmakh , A. Bahgat Radwan , Mostafa H. Sliem , Amin F. Majdalawieh , Gianfranco Pintus , Hadi M. Yassine , Aboubakr M. Abdullah , Sahar I. Da'as , Gheyath K. Nasrallah

Yıl :

2020

Ola Al-Jamal

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Ek Bilgiler

Kaydet

DOI : 10.1016/j.scitotenv.2020.140450

ISSN: 0048-9697
Cilt: 741
Sayfa: 140450

Sınıflandırma :

Çevre %71

Kirlilik %74