Piri Keşif Aracı

Ek Bilgiler

Kaydet

DOI : 10.1016/j.lpm.2010.04.022

ISSN: 0755-4982
Sayı: 10
Cilt: 39
Sayfa: 1040-1041

Sınıflandırma :

Hukuk %60

Afrika Ekonomisi %100

2

The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of the American Academy of Dermatology

Yayıncı:

Elsevier

Yazar(lar) :

Pascal Joly

Yıl :

2006

Pascal Joly

Özet Ek Bilgiler

Kaydet

Treatment of severe alopecia areata (AA) remains difficult. To assess the tolerance and efficacy of methotrexate (MTX) in the treatment of severe long-term AA, we retrospectively evaluated 22 patients with AA totalis or universalis with a mean duration of 11.0 ± 8.8 years who were treated with MTX either alone (n = 6) or associated with low doses of oral prednisone (n = 16). MTX was given at an initial weekly dosage of 15 mg (n = 3), 20 mg (n = 9), or 25 mg (n = 10). Oral prednisone was given at an initial dosage of 10 mg/d in one patient and 20 mg/d in 15 patients. In all, 14 patients (64%) achieved a total recovery including 3 of 6 patients treated by MTX alone and 11 of 16 who had received the combined treatment. Of the 14 patients who had total hair regrowth, 6 stopped MTX. In all, 3 patients maintained hair regrowth and 3 relapsed. Retreatment of these 3 patients by MTX resulted again in hair regrowth. No severe side effect was observed. Although limited by its uncontrolled character, this study shows that MTX and low doses of oral corticosteroids may be an effective and well-tolerated treatment for severe types of AA.

DOI : 10.1016/j.jaad.2005.09.010

Anahtar Kelimeler : AA alopecia areata, alopecia areata, CS corticosteroids, corticosteroids, IV intravenous, intravenous, MTX methotrexate, methotrexate

ISSN: 0190-9622
Sayı: 4
Cilt: 55
Sayfa: 632-636

Sınıflandırma :

Dermatoloji %99

3

Complex conjugate gradient methods

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Numerical Algorithms

Yazar(lar) :

Pascal Joly , Gérard Meurant

Konu :

Applied Mathematics

Yıl :

1993

Pascal Joly

Özet Ek Bilgiler

Kaydet

Linear systems with complex coefficients arise from various physical problems. Examples are the Helmholtz equation and Maxwell equations approximated by finite difference or finite element methods, that lead to large sparse linear systems. When the continuous problem is reduced to integral equations, after discretization, one obtains a dense linear system. The resulting matrices are generally non-Hermitian but, most of the time, symmetric and consequently the classical conjugate gradient method cannot be directly applied. Usually, these linear systems have to be solved with a large number of unknowns because, for instance, in electromagnetic scattering problems the mesh size must be related to the wave length of the incoming wave. The higher the frequency of the incoming wave, the smaller the mesh size must be. When one wants to solve 3D-problems, it is no longer practical to use direct method solvers, because of the huge memory they need. So iterative methods are attractive for this kind of problems, even though their convergence cannot be always guaranteed with theoretical results. In this paper we derive several methods from a unified framework and we numerically compare these algorithms on some test problems.

DOI : 10.1007/bf02145754

Anahtar Kelimeler : Conjugate gradient methods, linear systems, AMS(MOS) 65F10

ISSN: 1017-1398 1572-9265
Sayı: 3
Cilt: 4
Sayfa: 379-406

4

Bullous Pemphigoid and Pemphigus Vulgaris

Dergi Makalesi

Kaynak :

JSTOR

Dergi:

BMJ: British Medical Journal

Yazar(lar) :

Pascal Joly

Konu :

Medicine and Allied Health, Health Sciences

Yıl :

2008

Pascal Joly

Ek Bilgiler

Kaydet

Cilt: 337
Sayı: 7662
Sayfa: pp. 123-124
Yayın Tarihi: 2008-07-19
ISSN: 0959-8138

5

Pemphigus group (vulgaris, vegetans, foliaceus, herpetiformis, brasiliensis)

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinics in Dermatology

Yayıncı:

Elsevier

Yazar(lar) :

Pascal Joly , Noémie Litrowski

Yıl :

2011

Pascal Joly

Özet Ek Bilgiler

Kaydet

Pemphigus is a rare autoimmune bullous disorder involving the skin and mucosa. The disease has a chronic course. It is characterized histologically by an intraepidermal cleavage and the production of pathogenic antibodies directed against different proteins of the desmosomes, which belong to the cadherin family. The diagnosis of the type of pemphigus is made on clinical features, the level of histologic cleavage, and the identification of the antigens recognized by circulating autoantibodies using immunoblot or ELISA analysis of serum. The epidemiology and clinical, histologic, and immunologic findings of pemphigus vulgaris, pemphigus foliaceus, pemphigus vegetans, and pemphigus herpetiformis are described.

DOI : 10.1016/j.clindermatol.2011.01.013

ISSN: 0738-081X
Sayı: 4
Cilt: 29
Sayfa: 432-436

Sınıflandırma :

Dermatoloji %100

6

Pemphigus: autoimmune diseases of keratinocyte’s adhesion molecules

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinics in Dermatology

Yayıncı:

Elsevier

Yazar(lar) :

Philippe Martel , Pascal Joly

Yıl :

2001

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/s0738-081x(00)00191-7

ISSN: 0738-081X
Sayı: 6
Cilt: 19
Sayfa: 662-674

Sınıflandırma :

Tıp ve Halk Sağlığı %91

Dermatoloji %100

7

Editorial: Autoimmune Blistering Diseases

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Immunology

Yazar(lar) :

Cezary Kowalewski , Takashi Hashimoto , Pascal Joly

Yıl :

2020

Pascal Joly

Piri Tam Metin Bulucu Ek Bilgiler

Kaydet

DOI : 10.3389/fimmu.2020.01614

Anahtar Kelimeler : pemphigus, pemphigoid, dermatitis herpetiformis, pathgenesis of autoimmune blistering diseases, treatment of autoimmune blistering diseases

ISSN: 1664-3224
Cilt: 11

Sınıflandırma :

Biyotıp %99

Antikorlar %90

8

Pemphigus

Dergi Makalesi

Kaynak 1:

Science Direct

Dergi:

La Presse Médicale

Yayıncı:

Elsevier

Yazar(lar) :

Hélène Lapeyre-Liénard , Pascal Joly

Yıl :

2010

Pascal Joly

Yayıncı Web Siteleri

Özet Ek Bilgiler

Kaydet

Key points Pemphigus is a rare autoimmune blistering disorder involving the skin and mucosae. Three types of pemphigus have been described, including pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus. Diagnosis of the type of pemphigus is made by the combination of clinical features, histological and direct immunofluorescence findings, and serum analysis by indirect immunofluorescence, immunoblot analysis and enzyme-linked-immunosorbent-assay (Elisa). Most patients are treated with oral corticosteroids, sometimes associated with immunosuppressants. Patients with treatment failure or with contraindications to systemic corticosteroids and/or immunosuppressants may be treated with intravenous immunoglobulins or rituximab, an anti-CD20 monoclonal antibody. Points essentiels Le pemphigus est une maladie bulleuse auto-immune rare touchant la peau et les muqueuses. Il existe trois grands types anatomocliniques de pemphigus : vulgaire (clivage suprabasal), superficiel (clivage sous corné), paranéoplasique. En plus de l’analyse histologique, le diagnostic de pemphigus repose sur la mise en évidence des autoanticorps par les techniques d’immunofluorescence directe, immunofluorescence indirecte, immunotransfert et enzyme-linked-immunosorbent-assay (Elisa). Le traitement de base du pemphigus reste la corticothérapie générale souvent associée à des immunosupresseurs. En cas d’échec ou de contre-indication à la corticothérapie générale et aux immunosupresseurs, le rituximab (anticorps monoclonal anti-CD20) et les immunoglobulines intraveineuses peuvent être proposés.

Kaynak 1:

http://dx.doi.org/10.1016/j.lpm.2009.04.016 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.1016/s0140-6736(19)31778-7 arayıcılığı görüntüle.

DOI : 10.1016/j.lpm.2009.04.016

ISSN: 0755-4982
Sayı: 10
Cilt: 39
Sayfa: 1066-1070

Sınıflandırma :

Tıp ve Halk Sağlığı %96

Dermatoloji %100

9

Towards a method for solving partial differential equations by using wavelet packet bases

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Computer Methods in Applied Mechanics and Engineering

Yayıncı:

Elsevier

Yazar(lar) :

Pascal Joly , Yvon Maday , Valérie Perrier

Yıl :

1994

Pascal Joly

Özet Ek Bilgiler

Kaydet

In this paper we present a new methodology based on the wavelet packet concept, in order to define an adaptive method for the approximation of partial differential equations. The wavelet packet framework allows us to define the notion of a minimal basis that has proven to be an efficient procedure for data compression. The purpose here is to take benefit of this compression to represent accurately and economically the solution of a time dependent PDE. The time discretization is a standard multistep scheme. The spacial discretization is defined by inferring a reduced basis for the solution at the new time step, from the knowledge of the previous ones.

DOI : 10.1016/s0045-7825(94)80036-7

ISSN: 0045-7825
Sayı: 1-4
Cilt: 116
Sayfa: 301-307

Sınıflandırma :

Bilgisayar Bilimi %43

Algoritmalar %27

Sembolik ve Cebirsel Manipülasyon %19

Matematik %39

Fourier Analizi %72

10

Purification Studies of Thymosin α-1 in LC

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Chromatographia

Yazar(lar) :

Guy Félix , Pascal Joly , Serge Droux , Lucien Charles

Konu :

Organic Chemistry, Clinical Biochemistry, Biochemistry, Analytical Chemistry

Yıl :

2009

Pascal Joly

Özet Ek Bilgiler

Kaydet

The screening in column liquid chromatography of several reversed phase silica gels with various mobile phases was studied for the purification of thymosin α-1. Loading studies on analytical columns were developed and transposed to the preparative scale with a thymosin α-1 injection concentration of 1 g L−1. To obtain thymosin α-1 with a purity higher than 98%, a local pre-concentration was applied at the head of the column.

DOI : 10.1365/s10337-009-1194-9

Anahtar Kelimeler : Column liquid chromatography, Analytical and preparative scale, Purification, Thymosin α-1

ISSN: 0009-5893 1612-1112
Sayı: 3-4
Cilt: 70
Sayfa: 381-387

Sınıflandırma :

Kimya %99

Kromatografi %100

11

Treatment of Bullous Pemphigoid

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

The Journal of Dermatology

Yazar(lar) :

Juliette Fontaine , Pascal Joly , Jean-Claude Roujeau

Konu :

Dermatology, General Medicine

Yıl :

2003

Pascal Joly

Özet Ek Bilgiler

Kaydet

Bullous pemphigoid (BP) is the most frequent auto‐immune blistering skin disease. Up to recently, it was treated with oral corticosteroids. High dose steroids are poorly tolerated in the elderly and probably contributed to the high mortality rates observed in several cohorts. For years, efforts have been devoted to looking for steroid sparing agents including immunosuppressive drugs, plasma exchanges, intravenous immunoglobulins, tetracycline. Many seemed useful in open series but proved ineffective or marginally effective when tested in randomized controlled trials. An important breakthrough was the demonstration by a large randomized trial that a “super‐potent” topical corticosteroid (clobetasol propionate) was not only associated with a significant decrease in severe complications and mortality of BP patients but was also more effective than oral prednisone. New strategies for BP should include topical clobetasol propionate as the first line treatment and consider adjuvant therapy only in the very rare cases that are either resistant to or intolerant of this treatment.

DOI : 10.1111/j.1346-8138.2003.tb00353.x

ISSN: 0385-2407
Sayı: 2
Cilt: 30
Sayfa: 83-90

12

Balloon cell nevus: Histologic and dermoscopic features

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of the American Academy of Dermatology

Yayıncı:

Elsevier

Yazar(lar) :

Florie Dhaille , Philippe Courville , Pascal Joly , Xavier Balguerie

Yıl :

2015

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/j.jaad.2014.10.035

ISSN: 0190-9622
Sayı: 2
Cilt: 72
Sayfa: e55-e56

Sınıflandırma :

Dermatoloji %100

13

Individual patients’ risk factors impact guidelines for prophylactic agents used in pemphigus patients treated with rituximab

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of the American Academy of Dermatology

Yayıncı:

Elsevier BV

Yazar(lar) :

Dedee F. Murrell , Pascal Joly , Victoria P. Werth

Yıl :

2021

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/j.jaad.2021.03.018

ISSN: 0190-9622
Sayı: 1
Cilt: 85
Sayfa: e47-e48

Sınıflandırma :

Tıp ve Halk Sağlığı %99

İmmünoloji %58

Dermatoloji %37

14

Impact of COVID-19 on autoimmune blistering diseases

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinics in Dermatology

Yayıncı:

Elsevier BV

Yazar(lar) :

Kossara Drenovska , Snejina Vassileva , Ivan Tanev , Pascal Joly

Yıl :

2021

Pascal Joly

Özet Ek Bilgiler

Kaydet

Since the beginning of the COVID-19 outbreak, attention has gradually moved from the respiratory manifestations of the disease toward its dermatologic aspects. The need for wearing personal protective measures and their cutaneous side effects, detection of related or specific COVID-19 skin eruptions, and the evaluation of certain risk groups of immunosuppressed dermatologic patients have initiated significant discussions about various therapeutic interventions and, in particular, about biologic therapy for psoriasis and for autoinflammatory, orphan, or malignant cutaneous disorders. Autoimmune bullous dermatoses have been of concern due to their chronic course, at times life-threatening prognosis, and the need for prolonged and often aggressive immunomodulatory therapy. We have summarized the current knowledge regarding the impact of COVID-19 infection on autoimmune bullous dermatoses, including recommendations for the main treatment strategies, available patient information, and the registries organized for documentation during the COVID-19 pandemic.

DOI : 10.1016/j.clindermatol.2021.01.007

ISSN: 0738-081X
Sayı: 3
Cilt: 39
Sayfa: 359-368

Sınıflandırma :

Tıp ve Halk Sağlığı %93

Dermatoloji %85

15

ChemInform Abstract: Synthesis of 5,7-Dichloro-6-azaindoles and Functionalization via a Highly Selective Lithium-Chlorine Exchange.

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

ChemInform

Yazar(lar) :

Nicolas Lachance , Louis-Philippe Bonhomme-Beaulieu , Pascal Joly

Yıl :

2009

Pascal Joly

Özet Ek Bilgiler

Kaydet

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

DOI : 10.1002/chin.200928136

ISSN: 0931-7597
Sayı: 28
Cilt: 40

16

Synthesis of an amphiphilic aldehyde using as a key step the condensation of a lipophilic glyoxylic acid amide derivative with tris(hydroxymethyl)aminomethane

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Tetrahedron Letters

Yayıncı:

Elsevier

Yazar(lar) :

Dominique Bonnet , Pascal Joly , Hélène Gras-Masse , Oleg Melnyk

Yıl :

2001

Pascal Joly

Özet Ek Bilgiler

Kaydet

Spontaneous condensation of a glyoxylic acid amide derivative incorporating a palmitoyl group with tris(hydroxymethyl)aminomethane followed by Dess–Martin oxidation led to an heterocyclic amphiphilic aldehyde, which was successfully engaged in hydrazone formation in partial aqueous media.

DOI : 10.1016/s0040-4039(01)00032-6

ISSN: 0040-4039
Sayı: 10
Cilt: 42
Sayfa: 1875-1877

Sınıflandırma :

Kimya %100

Organik Kimya %99

17

Necrotizing pyoderma gangrenosum: An unusual differential diagnosis of necrotizing fasciitis

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of Plastic, Reconstructive & Aesthetic Surgery

Yayıncı:

Elsevier

Yazar(lar) :

Benoit Ayestaray , Emmanuel Dudrap , Emilie Chartaux , Eva Verdier , Pascal Joly

Yıl :

2010

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/j.bjps.2010.02.008

ISSN: 1748-6815
Sayı: 8
Cilt: 63
Sayfa: e655-e658

18

CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Immunology

Yazar(lar) :

Marie-Laure Golinski , Marie-Laure Golinski , Mélanie Demeules , Céline Derambure , Gaetan Riou , Maud Maho-Vaillant , Maud Maho-Vaillant , Olivier Boyer , Olivier Boyer , Pascal Joly , Pascal Joly , Sébastien Calbo

Yıl :

2020

Pascal Joly Pascal Joly

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

CD11c+ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c+ B cells from healthy donors by flow cytometry, microarray analysis, and in vitro functional assays. Here, we report that CD11c+ B cells are a distinct subpopulation of B cells, enriched in the memory subpopulation even if their phenotype is heterogeneous, with overexpression of genes involved in B-cell activation and differentiation as well as in antigen presentation. Upon activation, CD11c+ B cells can differentiate into antibody-secreting cells, and CD11c could be upregulated in CD11c− B cells by B-cell receptor activation. Finally, we show that patients with pemphigus, an autoimmune disease mediated by B cells, have a decreased frequency of CD11c+ B cell after treatment, relative to baseline. Our findings show that CD11c+ B cells are mainly memory B cells prone to differentiate into antibody secreting cells that accumulate with age, independently of gender.

DOI : 10.3389/fimmu.2020.00032

Anahtar Kelimeler : human, CD11c, B cells, microarray, plasma cells, pemphigus

ISSN: 1664-3224
Cilt: 11

Sınıflandırma :

Biyotıp %100

Antikorlar %66

19

Successful use of dabrafenib after the occurrence of drug rash with eosinophilia and systemic symptoms (DRESS) induced by vemurafenib

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

JAAD Case Reports

Yazar(lar) :

Camille Pinard , Claire Mignard , Agnès Samain , Anne-Bénédicte Duval-Modeste , Pascal Joly , PhD

Yıl :

2017

Pascal Joly

Ek Bilgiler

Kaydet

ISSN: 2352-5126
Cilt: 3
Sayı: 6
Sayfa: 532 - 533

Sınıflandırma :

Dermatoloji %97

20

An Organic–Inorganic Hybrid Composite as a Coating Agent

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Journal of the American Oil Chemists' Society

Yazar(lar) :

Akihiro Kuroda , Pascal Joly , Naoki Shibata , Hikari Takeshige , Kouichi Asakura

Konu :

Organic Chemistry, General Chemical Engineering

Yıl :

2008

Pascal Joly

Özet Ek Bilgiler

Kaydet

An organic–inorganic hybrid composite for use as a coating agent was prepared by mixing linseed oil with hydrophobic octylsilyl titanium dioxide particles having an average diameter of 35 nm (OSI‐TIO2‐35) in volatile silicone. The weight ratio of linseed oil with OSI‐TIO2‐35 was varied from 2:8 to 8:2 and the mixture was spread on a glass plate by dragging an applicator across it. After storing in the oven at 60 °C for 2 days, the composite having the weight ratio of OSI‐TIO2‐35 with linseed oil at 8:2 exhibited very high water‐repellent properties having a water contact angle of 148°. Variation of the water contact angle during storage at 60 °C was monitored. It decreased by 10° in the initial 8 h and then increased by 45° over the next 2 days. Composites containing silicone resin, TMSS BY11‐018, instead of linseed oil were also prepared. The sample having a weight ratio of OSI‐TIO2‐35 with TMSS BY11‐018 at 8:2 also exhibited very high water‐repellent properties with a water contact angle of 152°. The highly hydrophobic surface thus prepared by the coating and drying of those organic‐inorganic hybrid composites was easily transferred to highly hydrophilic surfaces by calcination at 500 °C for 3 h.

DOI : 10.1007/s11746-008-1230-1

ISSN: 0003-021X
Sayı: 6
Cilt: 85
Sayfa: 549-553

21

Tanning practice, perception, and sunburn among Emirati youth

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

International Journal of Dermatology

Yazar(lar) :

Ahmed S. Aldhaheri , Hassan Galadari , Muhammed J. Hashim , Pascal Joly

Yıl :

2017

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1111/ijd.13447

ISSN: 0011-9059
Sayı: 3
Cilt: 56
Sayfa: 354-357

Sınıflandırma :

Çevre %36

Çevre Hukuku %86

22

Association of major aphthous ulcers and nicorandil

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

The Lancet

Yayıncı:

Elsevier

Yazar(lar) :

Scarlette Agbo-Godeau , Pascal Joly , Philippe Lauret , Robert Szpirglas , Henri Szpirglas

Yıl :

1998

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/s0140-6736(05)61045-8

ISSN: 0140-6736
Sayı: 9140
Cilt: 352
Sayfa: 1598-1599

Sınıflandırma :

Biyotıp %100

Sitogenetik %58

23

Bullous pemphigoid lesions express a TH-2 cytokine profile

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of Dermatological Science

Yayıncı:

Elsevier

Yazar(lar) :

Pierre-André Bécherel , Pascal Joly , Sandra Ktorza , Camille Francès , Olivier Chosidow

Yıl :

1998

Pascal Joly

Ek Bilgiler

Kaydet

DOI : 10.1016/s0923-1811(98)83235-0

ISSN: 0923-1811
Cilt: 16
Sayfa: S40

Sınıflandırma :

Biyotıp %86

Tropik ilaç %27

24

COCHO-modified oxides nanoparticles by using phosphonic acid as grafting agent

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Tetrahedron Letters

Yayıncı:

Elsevier

Yazar(lar) :

Samiran Kar , Jean-Olivier Durand , Michel Granier , Pascal Joly , Oleg Melnyk

Yıl :

2003

Pascal Joly

Özet Ek Bilgiler

Kaydet

The synthesis of phosphonic acid 4 possessing a protected COCHO group, by using the Heck reaction is described. After grafting of the phosphonic acid 4 on metal oxides Al2O3, TiO2 or SnO2, the cleavage of the dithiane group was successful. The reactivity of the supported-COCHO group was examined by using model reactions with hydroxylamine and hydrazine derivatives.

DOI : 10.1016/s0040-4039(03)01367-4

ISSN: 0040-4039
Sayı: 30
Cilt: 44
Sayfa: 5617-5619

Sınıflandırma :

Kimya %95

Biyorganik Kimya %44

25

Modifications of the Transcriptomic Profile of Autoreactive B Cells From Pemphigus Patients After Treatment With Rituximab or a Standard Corticosteroid Regimen

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Immunology

Yazar(lar) :

Vivien Hébert , Vivien Hébert , Marie Petit , Maud Maho-Vaillant , Maud Maho-Vaillant , Marie-Laure Golinski , Marie-Laure Golinski , Gaëtan Riou , Céline Derambure , Olivier Boyer , Pascal Joly , Pascal Joly , Sébastien Calbo

Yıl :

2019

Pascal Joly Pascal Joly

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Pemphigus Vulgaris is an autoimmune disease of the skin and mucous membranes, which is due to the production of pathogenic autoantibodies targeting desmoglein (DSG) 1 and 3, which are adhesion proteins of the keratinocytes. Rituximab is an anti-CD20 mAb which induces a prolonged depletion of blood B cells. We recently showed that rituximab was more effective than a standard oral corticosteroid (CS) treatment, allowing 90% of patients to achieve complete remission (CR). Additionally, we showed that DSG-specific-B (DSG positive) cells were still detectable during the B cell recovery which follows the initial rituximab-induced B cell depletion, even in patients in CR. In order to characterize DSG positive B cells in patients in CR after rituximab or CS treatment relative to those detectable at baseline in patients with an active pemphigus, we studied the expression profile of 31 genes of interest related to inflammatory cytokines, TNF receptors and activation markers. Using quantitative Polymerase Chain Reaction performed on one cell with a microfluidic technique, we found that patients' autoreactive B cells collected at baseline had a significantly higher expression of genes encoding for IL-1β, IL-23p19, and IL-12p35 pro-inflammatory cytokines and the IRF5 transcription factor, than non-autoreactive B cells. Surprisingly, the gene expression profile of DSG positive B cells collected after rituximab treatment in patients in CR was close to that of DSG positive B cells at baseline in patients with active pemphigus, except for the IL-1β and the CD27 memory marker genes, which were under-expressed after rituximab compared to baseline. Conversely, we observed a decreased expression of genes encoding for IL-1β and IL-23p19 in patients treated with CS relative to baseline. This study showed that: (i) DSG positive autoreactive B cells have a different gene expression profile than non-autoreactive B cells; (ii) rituximab and CS have different effects on the genes' expression in autoreactive DSG positive B cells from pemphigus patients.

DOI : 10.3389/fimmu.2019.01794

Anahtar Kelimeler : pemphigus, rituximab, corticosteriods, autoreactive B cell, transcriptomic analysis

ISSN: 1664-3224
Cilt: 10

Sınıflandırma :

Biyotıp %100

Hematoloji %100

26

Long-Term Increase of Kcnn4 Potassium Channel Surface Expression on B Cells in Pemphigus Patients after Rituximab Treatment.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

J. Invest. Dermatol.

Yazar(lar) :

Frédérique Caillot , Céline Derambure , Nicolas Berkani , Gaëtan Riou , Maud Maho-Vaillant , Sébastien Calbo , Pascal Joly , Philippe Musette

Yıl :

2018

Pascal Joly

Piri Tam Metin Bulucu Ek Bilgiler

Kaydet

DOI : 10.1016/j.jid.2018.05.034

Sınıflandırma :

Biyotıp %74

Hematoloji %98

Tıp ve Halk Sağlığı %25

İmmünoloji %98

27

Synthesis and Chemical Reactivity ofα-Oxo Aldehyde-Supported Silicas

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

European Journal of Organic Chemistry

Yazar(lar) :

Samiran Kar , Pascal Joly , Michel Granier , Oleg Melnyk , Jean-Olivier Durand

Konu :

Physical and Theoretical Chemistry, Organic Chemistry

Yıl :

2003

Pascal Joly

Özet Ek Bilgiler

Kaydet

The synthesis and characterisation of α‐oxo aldehyde‐supported silicas by the sol‐gel procedure is described. The glyoxylyl group was generated after gelation, either by periodic oxidation of gluconamide chains or by deprotection of a diisopropylthioacetal‐protected derivative. The accessibility and reactivity of the supported α‐oxo aldehyde function was investigated in model reactions with hydroxylamine and hydrazine derivatives. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

DOI : 10.1002/ejoc.200300347

ISSN: 1434-193X
Sayı: 21
Cilt: 2003
Sayfa: 4132-4139

28

Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Clinical Reviews in Allergy & Immunology

Yazar(lar) :

Kyle T. Amber , Dedee F. Murrell , Enno Schmidt , Pascal Joly , Luca Borradori

Konu :

General Medicine, Immunology and Allergy

Yıl :

2017

Pascal Joly

Özet Ek Bilgiler

Kaydet

Autoimmune subepidermal blistering diseases of the skin and mucosae constitute a large group of sometimes devastating diseases, encompassing bullous pemphigoid, gestational pemphigoid, mucous membrane pemphigoid, epidermolysis bullosa acquisita, and anti-p200 pemphigoid. Their clinical presentation is polymorphic. These autoimmune blistering diseases are associated with autoantibodies that target distinct components of the basement membrane zone of stratified epithelia. These autoantigens represent structural proteins important for maintenance of dermo-epidermal integrity. Bullous pemphigoid (BP) is the most common subepidermal autoimmune blistering disease of the skin and mucosae. Although the disease typically presents with a generalized blistering eruption associated with itch, atypical variants with either localized bullous lesions or “non-bullous” presentations are observed in approximately 20% of patients. A peculiar form of BP typically associated with pregnancy is pemphigoid gestationis. In anti-p200 pemphigoid, patients present with tense blisters on erythematosus or normal skin resembling BP, with a predilection for acral surfaces. These patients have antibodies targeting the 200-kDa basement membrane protein. Epidermolysis bullosa is a rare autoimmune blistering disease associated with autoantibodies against type VII collagen that can have several phenotypes including a classical form mimicking dystrophic epidermolysis bullosa, an inflammatory presentation mimicking BP, or mucous membrane pemphigoid-like lesions. Mucous membrane pemphigoid (MMP) is the term agreed upon by international consensus for an autoimmune blistering disorder, which affects one or more mucous membrane and may involve the skin. The condition involves a number of different autoantigens in the basement membrane zone. It may result in severe complications from scarring, such as blindness and strictures. Diagnosis of these diseases relies on direct immunofluorescence microscopy studies and immunoserological assays. Management of affected patients is often challenging. We will here review the clinical and immunopathological features as well as the pathophysiology of this group of organ-specific autoimmune diseases. Finally, we will discuss the diagnostic approach and the principles of management in clinical practice.

DOI : 10.1007/s12016-017-8633-4

Anahtar Kelimeler : Autoimmune blistering disease, Bullous pemphigoid, Pemphigoid gestationis, Anti-p200 pemphigoid, Epidermolysis bullosa acquisita

ISSN: 1080-0549 1559-0267
Sayı: 1
Cilt: 54
Sayfa: 26-51

29

Polymyosite et pemphigus vulgaire : efficacité du rituximab chez une patiente

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Revue du Rhumatisme

Yayıncı:

Elsevier

Yazar(lar) :

Anne Tournadre , Stéphanie Amarger , Pascal Joly , Michel du2019Incan , Jean-Michel Ristori , Martin Soubrier

Yıl :

2008

Pascal Joly