Initially recognized of COVID-19 within the world in 2019, the World Health Organization situational report from May 22nd, 2020, globally, there is a complete of 5,204,508 confirmed cases, with 212 countries being affected by the novel coronavirus. 2019 novel coronavirus (SARS-CoV-2) is that the seventh member of the family of coronaviruses is enveloped viruses with a positive sense, single-stranded RNA genome. The SARS-CoV-2 may be a β-CoV of group 2B there is 70% comparability in genetic sequence to SARS-CoV. The source of the new coronavirus infection has been resolved as bats. With whole-genome sequences of SARS-CoV-2 is 96% comparatively at the whole-genome level to a bat coronavirus. Mechanisms of transmission are concluded to incorporate contact, droplet, and possibly airborne under certain circumstances supported ancient experiences associated with SARS-CoV outbreaks. Although antiretroviral therapy is being widely used everywhere the globe for such patents, effects at finding a SARS-CoV vaccine haven’t succeeded so far.
Our research work focussed on to evaluating the synergistic action of ethanolic extract and its formulations (F1 and F2) of Cinnamomum zeylanicum (ECZ) and Murraya koenigii (EMK) for antiobesity and anti-hyperlipidemic activity on the high-fat diet on wistar albino rats. In this research work, rats fed on high-fat diet produced hyperlipidemia (115.00 ± 1.36 mg/dL), which led to an gain in the body weight (215 g), the total cholesterol, triglycerides (166.0 ± 0.577 mg/dL), VLDL (33.20 ± 0.233 mg/dL), total bilirubin (3.280 ± 0.010 mg/dL) and subside the levels of HDL (41.0 ± 0.894 mg/dL) and also changes in albino rats body temperature. ECZ, EMK, and its formulation F1, F2 (200 mg/kg and 400 mg/kg) indicated less in comparison to the HFD induced rats group. The result of the study reflected that ECZ, EMK, and its formulation F1, F2 showed antiobesity and anti-hyperlipidemic action depending on the dose. It was concluded that the ethanolic extract of C. zeylanicum, M. koenigii and its formulation F1, F2 possess antiobesity and anti-hyperlipidemic activity. It is drawn to conclusions, alcoholic extract of C. zeylanicum and M. koenigii and its formulation F1 and F2 possess antiobesity and anti-hyperlipidemic activity.