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1
Altitude-Related Illnesses
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archivos de Bronconeumología (English Edition)
Yayıncı:
Elsevier
Yazar(lar) :
Roberto Alfonso Accinelli , Lidia Marianella López
Yıl :
2018
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1016/j.arbr.2018.01.002
ISSN: 1579-2129
Sayı: 3
Cilt: 54
Sayfa: 115-116
Sınıflandırma :
2
Pulmonary disease by mycobacterium intracellulare in an immunocompetent patient: Report of a case in Peru
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Revista Peruana de Medicina Experimental y Salud Pública
Yazar(lar) :
Roberto Alfonso Accinelli , Alfredo Camposano
Yıl :
2020
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
We present the case of an immunocompetent patient whose illness began at age 49 with a cough, followed by purulent and hemoptoic sputum; bronchiectasis was diagnosed. Three years later, after hemoptysis, she underwent medial segmentectomy of the middle lobe and was asymptomatic for months. When tuberculosis was found in the pathology report, she was treated with 4HREZ2R2H2. Five years later her BK was 2+, thus receiving a new scheme of 4HREZ2R2H2, which did not succeed in obtaining negative results and the treatment was declared as a failure. After genotyping her Mycobacterium intracellulare culture, the patient received azithromycin, moxifloxacin and ethambutol. There was improvement, but she abandoned the treatment at 8 months; she restarted it 18 months later, along with treatment for depression and gastroesophageal reflux. After one month the patient was asymptomatic, but she had a dermal reaction to moxifloxacin which was replaced with amikacin. One year later, she was cured and discharged, at the age of 64.
DOI : 10.17843/rpmesp.2020.372.4632
Anahtar Kelimeler : mycobacterium tuberculosis, complejo mycobacterium avium, reflujo gastroesofágico, micobacterias no tuberculosas, depresión
Cilt: 37
Sayı: 2
Sayfa: 361 - 6
Sınıflandırma :
3
At High Altitude COVID-19 Is Less Frequent: The Experience of Peru
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archivos de Bronconeumología (English Edition)
Yayıncı:
Elsevier BV
Yazar(lar) :
Roberto Alfonso Accinelli , Juan Alonso Leon-Abarca
Yıl :
2020
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1016/j.arbr.2020.09.004
ISSN: 1579-2129
Sayı: 11
Cilt: 56
Sayfa: 760-761
4
El asbesto, una epidemia todavía por controlar
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Gaceta Sanitaria
Yazar(lar) :
Roberto Alfonso Accinelli , Lidia Marianella López
Yıl :
2017
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1016/j.gaceta.2017.02.011
Cilt: 31
Sayı: 5
Sayfa: 365 - 367
5
Status of the Ban on Asbestos Use in Spain and Latin America
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archivos de Bronconeumología (English Edition)
Yayıncı:
Elsevier
Yazar(lar) :
Roberto Alfonso Accinelli Tanaka , Lidia Marianella López Oropeza
Yıl :
2015
Roberto Alfonso Accinelli Tanaka
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DOI : 10.1016/j.arbr.2014.12.011
ISSN: 1579-2129
Sayı: 3
Cilt: 51
Sayfa: 152
Sınıflandırma :
6
Age and altitude of residence determine anemia prevalence in Peruvian 6 to 35 months old children.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
PLoS ONE
Yazar(lar) :
Roberto Alfonso Accinelli , Juan Alonso Leon-Abarca
Yıl :
2020
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
BACKGROUND:A Demographic and Family Health Survey (ENDES, for Encuesta Demográfica y de Salud Familiar in Spanish) is carried out annually in Peru. Based on it, the anemia prevalence was 43.6% in 2016 and 43.8% in 2017 using the WHO cutoff value of 11 g/dL and the altitude-correction equation. OBJECTIVE:To assess factors contributing to anemia and to determine its prevalence in Peruvian children 6 to 35 months old. METHODS:We used the MEASURE DHS-based ENDES survey to obtain representative data for11364 children from 6 to 35 months old on hemoglobin and health determinants. To evaluate normal hemoglobin levels, we used the original WHO criterion of the 5th percentile in children without chronic malnutrition and then applied it to the overall population. Relationships between hemoglobin and altitude levels, usage of cleaning methods to sanitize water safe to drink, usage of solid fuels and poverty status were tested using methodology for complex survey data. Percentile curves were made for altitude intervals by plotting hemoglobin compared to age. The new anemia rates are presented in graphs by Peruvian political regions according to the degree of public health significance. RESULTS:Hemoglobin increased as age and altitude of residence increased. Using the 5th percentile, anemia prevalence was 7.3% in 2016 and 2017. Children from low altitudes had higher anemia prevalence (8.5%) than those from high altitudes (1.2%, p<0.0001). In the rainforest area of Peru, anemia prevalence was highest (13.5%), while in the highlands it was lowest (3.3%, p<0.0001). With access to safe drinking water and without chronic malnutrition, anemia rates could be reduced in the rainforest by 45% and 33%, respectively. CONCLUSION:Anemia prevalence in Peruvian children from 6 to 35 months old was 7.3% in 2016 and 2017.
DOI : 10.1371/journal.pone.0226846
ISSN: 1932-6203
Cilt: 15
Sayı: 1
Sayfa: e0226846
7
Antiviral and anti-inflammatory properties of ivermectin and its potential use in Covid-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archivos de Bronconeumología (English Edition)
Yayıncı:
Elsevier
Yazar(lar) :
Arianna Portmann-Baracco , Mayte Bryce-Alberti , Roberto Alfonso Accinelli
Yıl :
2020
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1016/j.arbr.2020.06.006
ISSN: 1579-2129

Sınıflandırma :
8
Reply to “Antiviral and anti-inflammatory properties of ivermectinand its potential use in Covid-19”
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Archivos de Bronconeumología (English Edition)
Yayıncı:
Elsevier BV
Yazar(lar) :
Roberto Alfonso Accinelli() , Arianna Portmann-Baracco , Mayte Bryce-Alberti
Yıl :
2020
Roberto Alfonso Accinelli()
Yayıncı Web Sitesi
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Kaydet Alıntıla
DOI : 10.1016/j.arbr.2020.11.002
ISSN: 1579-2129
Sayı: 12
Cilt: 56
Sayfa: 833
9
Hydroxychloroquine / azithromycin in COVID-19: The association between time to treatment and case fatality rate
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Travel Medicine and Infectious Disease
Yayıncı:
Elsevier BV
Yazar(lar) :
Roberto Alfonso Accinelli , Grisel Jesús Ynga-Meléndez , Juan Alonso León-Abarca , Lidia Marianella López , Juan Carlos Madrid-Cisneros , Juan Diego Mendoza-Saldaña
Yıl :
2021
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Background Currently, there is no formally accepted pharmacological treatment for COVID-19. Materials and methods We included COVID-19 outpatients of a Peruvian primary care center from Lima, Peru, who were treated between April 30 - September 30, 2020, with hydroxychloroquine and azithromycin. Logistic regression was applied to determine factors associated with case-fatality rate. Results A total of 1265 COVID-19 patients with an average age of 44.5 years were studied. Women represented 50.1% of patients, with an overall 5.9 symptom days, SpO2 97%, temperature of 37.3 °C, 41% with at least one comorbidity and 96.1% one symptom or sign. No patient treated within the first 72 h of illness died. The factors associated with higher case fatality rate were age (OR = 1.06; 95% CI 1.01–1.11, p = 0.021), SpO2 (OR = 0.87; 95% CI 0.79–0.96, p = 0.005) and treatment onset (OR = 1.16; 95% CI 1.06–1.27, p = 0.002), being the latter the only associated in the multivariate analysis (OR = 1.18; 95% CI 1.05–1.32, p = 0.005). 0.6% of our patients died. Conclusions The case fatality rate in COVID-19 outpatients treated with hydroxychloroquine/azithromycin was associated with the number of days of illness on which treatment was started.
DOI : 10.1016/j.tmaid.2021.102163
Anahtar Kelimeler : Hydroxychloroquine, Azithromycin, SARS-CoV-2, COVID-19, Mortality, Time-to-Treatment, Hydroxychloroquine (HCQ), (HCQ), Azithromycin (AZIT), (AZIT), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), (COVID-19), Angiotensin converting enzyme 2 (ACE2), (ACE2), Selectivity Index (SI), (SI), Mean Maximum Inhibitory Concentration (MIC50%), (MIC50%), Mean Cytotoxic Concentration (CC50%), (CC50%), Mean Effective Concentration (EC50), (EC50), Maternal-Infant Center (MIC), (MIC)
ISSN: 1477-8939
Cilt: 44
Sayfa: 102163
10
COVID-19: the novel SARS-CoV-2 pandemic
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Revista Peruana de Medicina Experimental y Salud Pública
Yazar(lar) :
Roberto Alfonso Accinelli , Cristian Mingxiong Zhang Xu , Jia-Der Ju Wang , José Miguel Yachachin-Chávez , Jaime Augusto Cáceres-Pizarro , Karla Beatriz Tafur-Bances , Roberto Gabriel Flores-Tejada , Alejandra del Carmen Paiva-Andrade
Yıl :
2020
Roberto Alfonso Accinelli
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
During the first weeks of 2020, cases of SARS-CoV-2 began to be reported outside of China, with a rapid increase in cases and deaths worldwide. SARS-CoV-2 is a positive single-stranded RNA virus, encased in a lipid bilayer derived from the host cell membrane and consists of four structural proteins (S, M, E and N), plus a haemagglutinin-sterase. The binding of the S protein to the ECA2 receptor allows the entry of the virus into the host cell and is a potential therapeutic target. 81% of patients develop mild symptoms, 14% have severe symptoms and 5% require intensive care management. Fever is the most frequent symptom, followed by cough and dyspnea. Most patients do not present leukocytosis, but they do present lymphopenia with sputum cultures that do not show other pathogens. In lung biopsies of severe patients, the most noticeable finding is diffuse alveolar damage. Radiologically, ground glass and alveolar patterns are observed; the lesions being predominantly basal, subpleural, and posterior, with a multifocal peripheral distribution, more affecting the right lower lobe. There is a marked inflammatory response, up to the cytokine storm, in which anti-inflammatory treatment with pulse therapy with methylprednisolone would be indicated. Although there are no large-scale studies regarding the use of chloroquine / hydroxychloroquine, due to the global situation, its use has been authorized for its anti-SARS-CoV-2 and anti-inflammatory effect, which can be potentiated with the use of azithromycin.
DOI : 10.17843/rpmesp.2020.372.5411
Anahtar Kelimeler : síndrome respiratorio agudo grave, neumonía viral, infecciones por coronavirus, pandemia
Cilt: 37
Sayı: 2
Sayfa: 302 - 11
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