Piri Keşif Aracı

Ek Bilgiler

DOI : 10.1002/rmv.2196

ISSN: 1052-9276

2

Genetic polymorphisms associated with obesity in the Arab world: a systematic review

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

International Journal of Obesity

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Salma Younes , Amal Ibrahim , Rana Al-Jurf , Hatem ZayedSalma Younes , Amal Ibrahim , Rana Al-Jurf , Hatem Zayed

Yıl :

2021

Salma Younes

Özet Ek Bilgiler

Abstract\n Background\n Obesity, one of the most common chronic health conditions worldwide, is a multifactorial disease caused by complex genetic and environmental interactions. Several association studies have revealed a considerable number of candidate loci for obesity; however, the genotype–phenotype correlations remain unclear. To date, no comprehensive systematic review has been conducted to investigate the genetic risk factors for obesity among Arabs.\n \n Objectives\n This study aimed to systematically review the genetic polymorphisms that are significantly associated with obesity in Arabs.\n \n Methods\n We searched four literature databases (PubMed, Science Direct, Scopus, and Google Scholar) from inception until May 2020 to obtain all reported genetic data related to obesity in Arab populations. Quality assessment and data extraction were performed individually by three investigators.\n \n Results\n In total, 59 studies comprising a total of 15,488 cases and 9,760 controls were included in the systematic review. A total of 76 variants located within or near 49 genes were reported to be significantly associated with obesity. Among the 76 variants, two were described as unique to Arabs, as they have not been previously reported in other populations, and 19 were reported to be distinctively associated with obesity in Arabs but not in non-Arab populations.\n \n Conclusions\n There appears to be a unique genetic and clinical susceptibility profile of obesity in Arab patients.\n

DOI : 10.1038/s41366-021-00867-6

ISSN: 0307-0565
Sayı: 9
Cilt: 45
Sayfa: 1899-1913

3

Drosophila as a Model Organism in Host–Pathogen Interaction Studies

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Cellular and Infection Microbiology

Yazar(lar) :

Salma Younes , Asma Al-Sulaiti , Elham Abdulwahab Ahmed Nasser , Hoda Najjar , Layla Kamareddine

Yıl :

2020

Salma Younes

Piri Tam Metin Bulucu Özet Ek Bilgiler

Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host–pathogen interactions and identifying chief factors involved in host defense and pathogen virulence in Drosophila serves as a foundation to establish novel strategies for infectious disease prevention and control in higher organisms, including humans.

DOI : 10.3389/fcimb.2020.00214

Anahtar Kelimeler : Drosophila, hostu2013pathogen interactions, host defense factors, pathogen virulence factors, disease control, disease progression

ISSN: 2235-2988
Cilt: 10

Sınıflandırma :

Yaşam Bilimleri %57

Mikrobiyal Genetik ve Genomik %66

Biyotıp %43

Gıda Mikrobiyolojisi %60

4

The spectrum of beta-thalassemia mutations in the 22 Arab countries: a systematic review

Dergi Makalesi

Kaynak :

Taylor and Francis

Dergi:

Expert Review of Hematology

Yayıncı:

Informa UK Limited

Yazar(lar) :

Aisha Moeen Khan , Asma Mohammed Al-Sulaiti , Salma Younes , Mohamed Yassin , Hatem Zayed

Konu :

Hematology

Yıl :

2020

Salma Younes

Ek Bilgiler

DOI : 10.1080/17474086.2021.1860003

ISSN: 1747-4086
Sayı: 1
Cilt: 14
Sayfa: 109-122

5

Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients – A Bioinformatics Approach

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Frontiers in Bioengineering and Biotechnology

Yazar(lar) :

S. Udhaya Kumar , D. Thirumal Kumar , R. Siva , C. George Priya Doss , Salma Younes , Nadin Younes , Mariem Sidenna , Hatem Zayed

Yıl :

2020

Salma Younes

Piri Tam Metin Bulucu Özet Ek Bilgiler

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, expression profiling of genes, animal models, and epigenetic findings that have paved the way for a better understanding of the molecular and genetic mechanisms of SLE. Our current study aimed to illustrate the essential genes and molecular pathways that are potentially involved in the pathogenesis of SLE. This study incorporates the gene expression profiling data of the microarray dataset GSE30153 from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between the B-cell transcriptomes of SLE patients and healthy controls were screened using the GEO2R web tool. The identified DEGs were subjected to STRING analysis and Cytoscape to explore the protein–protein interaction (PPI) networks between them. The MCODE (Molecular Complex Detection) plugin of Cytoscape was used to screen the cluster subnetworks that are highly interlinked between the DEGs. Subsequently, the clustered DEGs were subjected to functional annotation with ClueGO/CluePedia to identify the significant pathways that were enriched. For integrative analysis, we used GeneGo MetacoreTM, a Cortellis Solution software, to exhibit the Gene Ontology (GO) and enriched pathways between the datasets. Our study identified 4 upregulated and 13 downregulated genes. Analysis of GO and functional enrichment using ClueGO revealed the pathways that were statistically significant, including pathways involving T-cell costimulation, lymphocyte costimulation, negative regulation of vascular permeability, and B-cell receptor signaling. The DEGs were mainly enriched in metabolic networks such as the phosphatidylinositol-3,4,5-triphosphate pathway and the carnitine pathway. Additionally, potentially enriched pathways, such as the signaling pathways induced by oxidative stress and reactive oxygen species (ROS), chemotaxis and lysophosphatidic acid signaling induced via G protein-coupled receptors (GPCRs), and the androgen receptor activation pathway, were identified from the DEGs that were mainly associated with the immune system. Four genes (EGR1, CD38, CAV1, and AKT1) were identified to be strongly associated with SLE. Our integrative analysis using a multitude of bioinformatics tools might promote an understanding of the dysregulated pathways that are associated with SLE development and progression. The four DEGs in SLE patients might shed light on the pathogenesis of SLE and might serve as potential biomarkers in early diagnosis and as therapeutic targets for SLE.

DOI : 10.3389/fbioe.2020.00276

Anahtar Kelimeler : systemic lupus erythematosus, proteinu2013protein interactions, Metacore, microarray and bioinformatics, expression profiling data, biomarkers

ISSN: 2296-4185
Cilt: 8

Sınıflandırma :

Biyotıp %99

Metabolik Hastalıklar %24

6

Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Molecular Genetics and Metabolism Reports

Yayıncı:

Elsevier

Yazar(lar) :

Ali Zaki Ibrahim , D. Thirumal Kumar , Taghreed Abunada , Salma Younes , C. George Priya Doss , Osama K. Zaki , Hatem Zayed

Yıl :

2020

Salma Younes

Ek Bilgiler

DOI : 10.1016/j.ymgmr.2020.100645

ISSN: 2214-4269
Cilt: 25
Sayfa: 100645

Sınıflandırma :

Biyotıp %100

Metabolik Hastalıklar %100

7

Enhanced production of anthraquinones by gamma-irradiated cell cultures of Rubia cordifolia in a bioreactor

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Industrial Crops and Products

Yayıncı:

Elsevier

Yazar(lar) :

Mariadoss A , Ramesh Satdive , Devanand P. Fulzele , Siva Ramamoorthy , George Priya Doss C , Hatem Zayed , Salma Younes , Rajasekaran C

Yıl :

2020

Salma Younes

Ek Bilgiler

DOI : 10.1016/j.indcrop.2019.111987

ISSN: 0926-6690
Cilt: 145
Sayfa: 111987

Sınıflandırma :

Yaşam Bilimleri %90

Hücre kültürü %96

8

Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2

Dergi Makalesi

Kaynak 1:

MDPI

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Viruses

Yayıncı:

MDPI AG

Yazar(lar) :

Nadin Younes , Duaa W. Al-Sadeq , Hadeel AL-Jighefee , Salma Younes , Ola Al-Jamal , Hanin I. Daas , Hadi. M. Yassine , Gheyath K. Nasrallah

Yıl :

2020

Salma Younes

Yayıncı Web Siteleri

Özet Ek Bilgiler

The recent outbreak of the Coronavirus disease 2019 (COVID-19) has quickly spread worldwide since its discovery in Wuhan city, China in December 2019. A comprehensive strategy, including surveillance, diagnostics, research, clinical treatment, and development of vaccines, is urgently needed to win the battle against COVID-19. The past three unprecedented outbreaks of emerging human coronavirus infections at the beginning of the 21st century have highlighted the importance of readily available, accurate, and rapid diagnostic technologies to contain emerging and re-emerging pandemics. Real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) based assays performed on respiratory specimens remain the gold standard for COVID-19 diagnostics. However, point-of-care technologies and serologic immunoassays are rapidly emerging with high sensitivity and specificity as well. Even though excellent techniques are available for the diagnosis of symptomatic patients with COVID-19 in well-equipped laboratories; critical gaps still remain in screening asymptomatic people who are in the incubation phase of the virus, as well as in the accurate determination of live viral shedding during convalescence to inform decisions for ending isolation. This review article aims to discuss the currently available laboratory methods and surveillance technologies available for the detection of COVID-19, their performance characteristics and highlight the gaps in current diagnostic capacity, and finally, propose potential solutions. We also summarize the specifications of the majority of the available commercial kits (PCR, EIA, and POC) for laboratory diagnosis of COVID-19.

Kaynak 1: http://dx.doi.org/10.3390/v12060582 arayıcılığı görüntüle.
Kaynak 2: https://doi.org/10.3390/v12060582 arayıcılığı görüntüle.

DOI : 10.3390/v12060582

ISSN: 1999-4915
Sayı: 6
Cilt: 12
Sayfa: 582

Sınıflandırma :

Tıp ve Halk Sağlığı %87

Bulaşıcı Hastalıklar %93

9

A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis

Kitap Bölümü

Kaynak :

Science Direct

Dergi:

Proteomics and Systems Biology

Yayıncı:

Elsevier

Yazar(lar) :

S. Udhaya Kumar , Aisha Saleem , D. Thirumal Kumar , V. Anu Preethi , Salma Younes , Hatem Zayed , Iftikhar Aslam Tayubi , C. George Priya Doss

Yıl :

2021

Salma Younes

Ek Bilgiler

DOI : 10.1016/bs.apcsb.2021.02.002

ISSN: 1876-1623
Sayfa: 343-364

10

Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Cell Biochemistry and Biophysics

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

S. Udhaya Kumar , Srivarshini Sankar , D. Thirumal Kumar , Salma Younes , Nadin Younes , R. Siva , C. George Priya Doss , Hatem Zayed

Yıl :

2021

Salma Younes

Ek Bilgiler

DOI : 10.1007/s12013-020-00960-z

ISSN: 1085-9195
Sayı: 2
Cilt: 79
Sayfa: 201-219

11

An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)—A systems biology approach

Kitap Bölümü

Kaynak :

Science Direct

Dergi:

Proteomics and Systems Biology

Yayıncı:

Elsevier

Yazar(lar) :

S. Udhaya Kumar , N. Madhana Priya , D. Thirumal Kumar , V. Anu Preethi , Vibhaa Kumar , Dhanushya Nagarajan , R. Magesh , Salma Younes , Hatem Zayed , C. George Priya Doss

Yıl :

2021

Salma Younes

Ek Bilgiler

DOI : 10.1016/bs.apcsb.2021.02.004

ISSN: 1876-1623
Sayfa: 315-342

12

Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors

Dergi Makalesi

Kaynak :

Science Direct

Yazar(lar) :

Mohamed.A. Ismail , Gheyath K. Nasrallah , Maria Monne , Ali AlSayab , Mohamed A. Yassin , Govindarajulu Varadharaj , Salma Younes , Claudio Sorio , Richard Cook , Helmout Modjtahedi , Nader I. Al-Dewik

Yıl :

2021

Salma Younes

Ek Bilgiler

DOI : 10.1016/j.gene.2021.146101

ISSN: 0378-1119
Sayfa: 146101

13

A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

3 Biotech

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

S. Udhaya Kumar , N. Madhana Priya , S. R. Nithya , Priyanka Kannan , Nikita Jain , D. Thirumal Kumar , R. Magesh , Salma Younes , Hatem Zayed , C. George Priya Doss

Yıl :

2021

Salma Younes

Ek Bilgiler