Piri Keşif Aracı

Özet Ek Bilgiler

The most common mechanizm of methicillin resistance in staphylococci is the synthesis of a new penicillin binding protein (PBP2a). The genetic material responsible for PBP 2a syhthesis is carried in mec A gene. Only methicillin resistant staphylococci have this gene. It can be trasported to sensitive strains by transduction. There are also other genes (factor X, fem A, fem B, mec R mec I) which control the expression of mec A gene. As a result of interaction of these genes 2 types of PBP 2a related methicillin resistance occurs: Homogenous resistance, heterogeneous resistance. Besides chromosomal (intrinsic) resistance, methicillin resistnace in staphylococci can develop through secretion of beta lactamase enzymes or decrease in the affinity of PBS’s to beta lactam antibiotics.

Anahtar Kelimeler : Staphylococci, Methicillin Resistance

ISSN: 1300-932X
Cilt: 1
Sayı: 1
Sayfa: 14 - 17

Sınıflandırma :

Biyotıp %58

İlaç Direnci %100

Yaşam Bilimleri %42

Tıbbi Mikrobiyoloji %91

2

CDC 2013 Urinary Tract Infections with New Diagnostic Criteria

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Serhat ÜNAL

Yıl :

2014

Serhat ÜNAL

Ek Bilgiler

ISSN: 1300-932X
Cilt: 19
Sayı: 3
Sayfa: 118 - 145

3

Resistance to antimicrobial agents in Mediterranean countries

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

International Journal of Antimicrobial Agents

Yayıncı:

Elsevier

Yazar(lar) :

Deniz Gür , Serhat Ünal

Yıl :

2001

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/s0924-8579(00)00310-1

ISSN: 0924-8579
Sayı: 1
Cilt: 17
Sayfa: 21-26

Sınıflandırma :

Yaşam Bilimleri %61

Tıbbi Mikrobiyoloji %58

4

Management of Community-Acquired Pneumonia in Immunocompetent Adults in Turkey

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Hakan ERDEM , Serhat ÜNAL

Yıl :

2007

Serhat ÜNAL

Ek Bilgiler

Anahtar Kelimeler : Pneumonia, Community-acquired infections, Treatment, Immunocompetence

ISSN: 1300-932X
Cilt: 12
Sayı: 2
Sayfa: 67 - 79

Sınıflandırma :

Biyotıp %87

Viroloji %57

Parazitoloji ve Enfeksiyon Hastalıkları %20

5

Fever in the Intensive Care Unit

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Gökhan METAN , Serhat ÜNAL

Yıl :

2004

Serhat ÜNAL

Ek Bilgiler

Anahtar Kelimeler : Fever, Intensive care

ISSN: 1300-932X
Cilt: 9
Sayı: 3
Sayfa: 172 - 182

6

Novel Coronavirus (SARS-CoV-2) Pandemic: Overview and Current Status

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Şehnaz ALP , Serhat ÜNAL

Yıl :

2020

Serhat ÜNAL

Özet Ek Bilgiler

In the end of December 2019, a novel coronavirus was identified as the cause of pneumonia cases in Wuhan, China. The disease was later named as COVID-19 (coronavirus disease 2019) and the causative agent was designated as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Even though the disease was suggested to be of zoonotic origin, human to human spread was also described and became the main mode of transmission. The number of cases significantly increased within a short period of time and the disease spread worldwide. On March 11, 2020, the World Health Organization announced COVID-19 outbreak as a pandemic. As of May 6, 2020, it has been reported that there are 3.588.773 people diagnosed with COVID-19 among 215 countries, territories or areas, and 247.503 people have died from the disease. In our country, the first case was identified on March 10, 2020, and the first death from the disease was reported on March 17, 2020. According to the data announced on May 6, 2020, the total number of cases detected in our country was 131.744, and the number of deaths related to the disease was 3584. The knowledge on the characteristics and epidemiology of SARS-CoV-2 and COVID-19 has been increasing day by day. Sequence analysis of the viral genome enabled the development of diagnostic tests and facilitated the initiation of research on both therapeutic options and vaccine development. In this review article, current information on the biology, epidemiology, clinical features, diagnosis, treatment, and prevention of SARS-CoV-2 and COVID-19 was discussed.

DOI : 10.5578/flora.69574

Anahtar Kelimeler : severe acute respiratory syndrome coronavirus 2, sars-cov-2, coronavirus disease-2019, covid-19, novel coronavirus

ISSN: 1300-932X
Cilt: 25
Sayı: 2
Sayfa: 111 - 120

Sınıflandırma :

Biyotıp %67

Tropik ilaç %58

Viroloji %25

Tıp ve Halk Sağlığı %32

Bulaşıcı Hastalıklar %69

7

Viral Load Measurement in HIV/AIDS Patients

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Serdar TUNCER , Serhat ÜNAL

Yıl :

1997

Serhat ÜNAL

Özet Ek Bilgiler

With respect to HIV pathogenesis, it is known that the asymptomatic, so called clinical latency phase is far from the quiescent period it was once thought to be. More potent antiretroviral drugs and their use in clinical trials made viral load measurements quite important. Rapid and reliable quantitative assays for viral load are possible by the use of nucleic acid amplification techniques. New and accurate means of monitoring viral load by these techniques are now available to predict disease progression and monitor the effects of the therapy. It is now recommended that both viral load measurement and CD4+ T-cell count should be used concurrently to manage HIV disease and to evaluate new drugs.

Anahtar Kelimeler : Viral Load, Nucleic Acid Amplification

ISSN: 1300-932X
Cilt: 2
Sayı: 3
Sayfa: 159 - 163

Sınıflandırma :

Biyotıp %96

Viroloji %96

8

Risk factors influencing clinical outcome in Staphylococcus aureus bacteraemia in a Turkish University Hospital

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

International Journal of Antimicrobial Agents

Yayıncı:

Elsevier

Yazar(lar) :

Arzu Topeli , Serhat Ünal , H.Erdal Akalin

Yıl :

2000

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/s0924-8579(99)00147-8

ISSN: 0924-8579
Sayı: 1
Cilt: 14
Sayfa: 57-63

Sınıflandırma :

Biyotıp %85

İlaç Direnci %100

9

2019 Coronavirus Pandemic in Turkey and Across the World

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Ahmet Görkem ER , Serhat ÜNAL

Yıl :

2020

Serhat ÜNAL

Özet Ek Bilgiler

The novel coronavirus, which was called 2019-nCoV at the beginning of the outbreak, was named SARS-CoV-2 later. The clinical disease caused by the virus was also called Coronavirus disease 2019 (COVID-19). World Health Organization declared COVID-19 a global pandemic on 11.03.2020. As of 26.03.2020, there have been 462.684 confirmed cases and 20.834 deaths globally, and these numbers are expected to increase in the coming days. The dynamics of virus spread are investigated with various models and outbreak parameters such as incubation time and basic reproduction number (R0) is tried to be illuminated. According to official numbers, as of 03.26.2020, there have also been 3629 cases and 75 deaths in Turkey. COVID-19 Guideline prepared by the Ministry of Health of the Republic of Turkey is constantly updated with additional prevention and treatment strategies. Various predictions are made for the future course of the pandemic, and the contribution of the spread of the virus in Africa and seasonal changes on this issue has been investigated.

DOI : 10.5578/flora.202001

Anahtar Kelimeler : sars-cov-2, coronavirus pandemic, covid-19, turkey

ISSN: 1300-932X
Cilt: 25
Sayı: 1
Sayfa: 1 - 8

Sınıflandırma :

Tıp ve Halk Sağlığı %44

Bulaşıcı Hastalıklar %85

Biyotıp %30

Parazitoloji ve Enfeksiyon Hastalıkları %46

Viroloji %21

10

Paradoksik Cevap Görülen Bir Miliyer Tüberküloz Olgusu

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Serhat ÜNAL , İbrahim Koral ÖNAL

Yıl :

2004

Serhat ÜNAL

Ek Bilgiler

ISSN: 1300-932X
Cilt: 9
Sayı: 3
Sayfa: 232 - 232

Sınıflandırma :

Tıp ve Halk Sağlığı %100

11

Natural History and Classification of HIV Disease and Initial Evaluation of HIV Infected Adult Patient

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Gülay SAİN GÜVEN , Serhat ÜNAL

Yıl :

2001

Serhat ÜNAL

Ek Bilgiler

Anahtar Kelimeler : Human immunodeficiency virus (HIV), Acquired immunodeficiency syndrome (AIDS), Classification, Initial evaluation

ISSN: 1300-932X
Cilt: 6
Sayı: 1
Sayfa: 12 - 21

Sınıflandırma :

Biyotıp %77

Viroloji %93

Tıp ve Halk Sağlığı %23

Bulaşıcı Hastalıklar %99

12

New Therapeutic Approaches in Sepsis

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Mine DURUSU TANRIÖVER , Serhat ÜNAL

Yıl :

2004

Serhat ÜNAL

Ek Bilgiler

Anahtar Kelimeler : Sepsis, Therapy, Activated protein C, Heme oxygenase, Ethyl pyruvate, Carbonmonoxide

ISSN: 1300-932X
Cilt: 9
Sayı: 4
Sayfa: 237 - 245

Sınıflandırma :

Biyotıp %100

Antikorlar %49

13

An Alternative Medical Diagnosis Method: Biosensors for Virus Detection

Dergi Makalesi

Kaynak 1:

MDPI

Kaynak 2:

Directory of Open Access Journals (DOAJ)

Dergi:

Biosensors

Yayıncı:

MDPI AG

Yazar(lar) :

Yeşeren Saylan , Özgecan Erdem , Serhat Ünal , Adil Denizli

Yıl :

2019

Serhat Ünal

Yayıncı Web Siteleri

Özet Ek Bilgiler

Infectious diseases still pose an omnipresent threat to global and public health, especially in many countries and rural areas of cities. Underlying reasons of such serious maladies can be summarized as the paucity of appropriate analysis methods and subsequent treatment strategies due to the limited access of centralized and equipped health care facilities for diagnosis. Biosensors hold great impact to turn our current analytical methods into diagnostic strategies by restructuring their sensing module for the detection of biomolecules, especially nano-sized objects such as protein biomarkers and viruses. Unquestionably, current sensing platforms require continuous updates to address growing challenges in the diagnosis of viruses as viruses change quickly and spread largely from person-to-person, indicating the urgency of early diagnosis. Some of the challenges can be classified in biological barriers (specificity, low number of targets, and biological matrices) and technological limitations (detection limit, linear dynamic range, stability, and reliability), as well as economical aspects that limit their implementation into resource-scarce settings. In this review, the principle and types of biosensors and their applications in the diagnosis of distinct infectious diseases were comprehensively explained. The deployment of current biosensors into resource-scarce settings is further discussed for virus detection by elaborating the pros and cons of existing methods as a conclusion and future perspective.

Kaynak 1: http://dx.doi.org/10.3390/bios9020065 arayıcılığı görüntüle.
Kaynak 2: https://doi.org/10.3390/bios9020065 arayıcılığı görüntüle.

DOI : 10.3390/bios9020065

ISSN: 2079-6374
Sayı: 2
Cilt: 9
Sayfa: 65

Sınıflandırma :

Biyotıp %54

Gıda Mikrobiyolojisi %21

14

Comparison of Diagnostic Subgroup Survivals of Patients Who Admitted for Fever of Unknown Etiology Evaluation: Long-term Results of Single-centre, Prospective Study

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Emre BİLGİN , Serhat ÜNAL , Umut KALYONCU

Yıl :

2019

Serhat ÜNAL

Özet Ek Bilgiler

Introduction: Fever of unknown origin (FUO) is one of the most challenging clinical situations. Although several studies have shown a relatively benign course of patients that remain undiagnosed, long-term outcoms of patients with a certain diagnosis are still non-established. To describe the follow-up results of patients investigated for FUO, with a certain diagnosis. Materials and Methods: Data from patients admitted to the inpatient clinics of Hacettepe University Hospital inpatients Department of Internal Medicine with the complaint of FUO were collected prospectively from March 2015 to September 2017. Patients with an uncertain diagnosis after all diagnostic procedures were excluded. Patients were divided into 3 main subgroups: rheumatologic, infectious and malignant groups. We compared Kaplan-Meier curves for all diagnosis-to-death time frames with the standart log-rank test. p< 0.05 was considered as statistically significant. Results: A total of 106 patients were included, 58 (55%) of them were female. Median age was 48 (18-81) years. Patients were also divided into three subgroups: rheumatologic (RHE) (n= 49, 46.2%), infectious (INF) (n= 28, 26.4%) and malignant (MLG) (n= 29, 27.4%) causes; adult-onset Still’s disease (n= 20; 41% of), tuberculosis (n= 9; 32%) and lymphoma (n= 19; 66%) were the most common diagnosis among the groups, respectively. While there was no survival difference between the rheumatologic and infectious group, both of these groups had better survival than the malignant group (ROM-INF p= 0.13; ROM-MLG p= 0.001; INF-MLG p= 0.022). Among the female patients, there was only a significant survival difference between the rheumatologic and malignant group (ROM-INF p= 0.15; ROM-MLG p= 0.007; INF-MLG p= 0.42). Conclusion: Among the patients evaluated for FUO, survival rate was lower in patients who had a malignant diagnosis. Despite having lost its statistical significance after stratification for gender, mortality rate of the infectious group was followed the malignant group. Early diagnosis and treatment of infections may lower mortality rates. Further large-scaled epidemiological studies are needed.

DOI : 10.5578/flora.68036

Anahtar Kelimeler : Fever of unknown origin, Mortality, Infectious diseases

ISSN: 1300-932X
Cilt: 24
Sayı: 3
Sayfa: 199 - 206

15

Production of surface plasmon resonance based assay kit for hepatitis diagnosis

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Biosensors and Bioelectronics

Yayıncı:

Elsevier

Yazar(lar) :

Lokman Uzun , Rıdvan Say , Serhat Ünal , Adil Denizli

Yıl :

2009

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/j.bios.2009.02.021

ISSN: 0956-5663
Sayı: 9
Cilt: 24
Sayfa: 2878-2884

Sınıflandırma :

Kimya %77

Biyoteknoloji %81

16

Knowledge and Attitudes Among Hospital Pharmacists About COVID-19

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Turkish Journal of Pharmaceutical Sciences

Yazar(lar) :

Emre KARA , Kutay DEMİRKAN , Serhat ÜNAL

Yıl :

2020

Serhat ÜNAL

Piri Tam Metin Bulucu Özet Ek Bilgiler

Objectives:Coronavirus (COVID-19) cases and deaths related to the virus have been reported all over the world. Pharmacists play an important role in conveying accurate information about COVID-19 to the community. The aim of this study was to evaluate the knowledge and attitudes among hospital pharmacists about COVID-19.Materials and Methods:A questionnaire was distributed to pharmacists participating in the 7th National Hospital and Institution Pharmacists Congress. The questions included in this questionnaire were created using the Turkish COVID-19 Scientific Committee guideline (COVID-19 Guideline).Results:Analysis of 237 questionnaires (72.6% completed by women) showed that the media (television, newspaper), internet (nonscientific resources), internet (scientific resources), and social media were the most popular sources of information (60.3%, 53.6%, 53.2%, and 41.4%, respectively). The participants’ age and the source of information that they used had an important influence on their knowledge of and attitudes towards COVID-19 infection. The majority of the participants (72.6%) stated that they were not wearing any kind of mask. Transmission of the disease by airborne route was well known by the participants (91.1%), as well as the main symptoms such as fever (92.4%), cough (84.4%), and dyspnea (60.3%). The participants were aware of the risk groups for COVID-19 infection such as advanced age (84.8%) and having comorbidities (80.2%). Washing hands with soap (92.0%), using hand disinfectants (80.6%), and avoiding contact with sick people (81.9%) were popular answers for protection from the disease, but wearing an N95 mask was also mentioned by 59.1% of the participants. Prevention of the disease by rinsing the nose with saline solution was believed in by 43.9% of the participants.Conclusion:Classical media and social media affect the attitudes of both the public and health professionals. Using media tools for accurate information is one of the basic conditions for preventing and controlling the spread of the disease.

DOI : 10.4274/tjps.galenos.2020.72325

Anahtar Kelimeler : covid-19, hospital pharmacists, knowledge, attitudes

Cilt: 17
Sayı: 3
Sayfa: 242 - 248

Sınıflandırma :

Tıp ve Halk Sağlığı %64

Sağlığı Geliştirme ve Hastalık Önleme %42

17

Comparative in vitro activity of trovafloxacin against Gram-negative and Gram-positive pathogens

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinical Microbiology and Infection

Yayıncı:

Elsevier

Yazar(lar) :

Deniz Gür , Sesin Kocagöz , Serhat Ünal , Erdal Akalin

Yıl :

1998

Serhat Ünal

Ek Bilgiler

DOI : 10.1111/j.1469-0691.1998.tb00410.x

ISSN: 1198-743X
Sayı: 9
Cilt: 4
Sayfa: 530-532

Sınıflandırma :

Biyotıp %88

İlaç Direnci %63

18

Hepatitis B surface antibody purification with hepatitis B surface antibody imprinted poly(hydroxyethyl methacrylate-N-methacryloyl-l-tyrosine methyl ester) particles

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of Chromatography B

Yayıncı:

Elsevier

Yazar(lar) :

Lokman Uzun , Ridvon Say , Serhat Ünal , Adil Denizli

Yıl :

2009

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/j.jchromb.2008.12.004

ISSN: 1570-0232
Sayı: 3
Cilt: 877
Sayfa: 181-188

Sınıflandırma :

Kimya %100

Kromatografi %73

19

Influenza A (H7N9): Is a Brand-new Pandemic at the Gates?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Fatma AKSOY , Ahmet Çağkan İNKAYA , Serhat ÜNAL

Yıl :

2013

Serhat ÜNAL

Ek Bilgiler

ISSN: 1300-932X
Cilt: 18
Sayı: 1
Sayfa: 1 - 3

Sınıflandırma :

Biyotıp %93

20

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Dergi Makalesi

Kaynak :

MDPI

Dergi:

Sensors

Yayıncı:

MDPI AG

Yazar(lar) :

Yeşeren Saylan , Semra Akgönüllü , Handan Yavuz , Serhat Ünal , Adil Denizli

Yıl :

2019

Serhat Ünal

Özet Ek Bilgiler

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

DOI : 10.3390/s19061279

ISSN: 1424-8220
Sayı: 6
Cilt: 19
Sayfa: 1279

Sınıflandırma :

Kimya %99

Nanokimya %47

21

Avian Influenza: Epidemiology, Pathogenesis, Clinical Features and Treatment

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Gül Ruhsar YILMAZ , Mustafa Aydın ÇEVİK , Serhat ÜNAL

Yıl :

2007

Serhat ÜNAL

Ek Bilgiler

Anahtar Kelimeler : Avian influenza, Influenza

ISSN: 1300-932X
Cilt: 12
Sayı: 1
Sayfa: 26 - 45

22

Comparison of Laboratory Methods for Detection of Pneumocystis carinii

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Serdar TUNCER , Sibel ERGÜVEN , Sesin KOCAGÖZ , Serhat ÜNAL

Yıl :

1998

Serhat ÜNAL

Özet Ek Bilgiler

Detection of P. carinii is increased by the use of polymerase chain reaction (PCR), particularly on sputum samples. In this study, sputum samples obtained from 30 immunosuppressed patients with respiratory symptoms (12 HIV infected) were tested by standard cytochemical staining (Giemsa and methenamine silver), immunofluorescense (IF) staining and PCR for detection of P. carinii and the results were compared. P. carinii were detected in 4, 8, and 13 sputum samples by cytological staining, IF test and PCR, respectively. Specific amplification bands were obtained in all sputum samples which were positive by both other tests. All tests gave negative results in sputum samples obtained from 5 HIV infected asymptomatic patients. Our observations suggest that PCR results were found to be well correlated with P. carinii pneumonia (PCP) especially in non-HIV infected patients. However, PCR positivity obtained on HIV infected patients could be misleading in the diagnosis of PCP without careful clinical evaluation. Positive results obtained by Giemsa staining or IF test confirm diagnosis of PCP with high degree correlation. As a result, we suggest testing sputum samples by both PCR and IF techniques for detection of P. carinii.

Anahtar Kelimeler : Pneumocystis carini, Diagnosis, Immunofluorescense

ISSN: 1300-932X
Cilt: 3
Sayı: 1
Sayfa: 20 - 25

Sınıflandırma :

Biyotıp %100

Viroloji %40

Biyotıp %23

Görüntüleme ve Radyoloji %23

23

Nephrotoxicity of piperacillin/tazobactam combined with vancomycin: should it be a concern?

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Int. J. Antimicrob. Agents

Yazar(lar) :

Cafer Balcı , Ömrüm Uzun , Mustafa Arıcı , Sibel Aşçıoğlu Hayran , Deniz Yüce , Serhat Ünal

Konu :

Acute Kidney Injury, Adult, Aged, Creatinine, Drug Therapy, Combination, Female, Humans, Kidney, Logistic Models, Male, Meropenem, Methicillin-Resistant Staphylococcus aureus, Middle Aged, Penicillanic Acid, Piperacillin, Piperacillin, Tazobactam Drug Combination, Pseudomonas Infections, Pseudomonas aeruginosa, Retrospective Studies, Staphylococcal Infections, Thienamycins, Vancomycin

Yıl :

2018

Serhat Ünal

Piri Tam Metin Bulucu Özet

The combination of piperacillin/tazobactam (TZP) and vancomycin (VAN) provides a wide spectrum of activity against many pathogens acquired in healthcare settings. However, there have been reports of increased potential for nephrotoxicity with this combination. The aim of this study was to evaluate the nephrotoxic effect of TZP+VAN and to compare it with that of TZP and VAN monotherapies as well as VAN + meropenem (MEM), another broad-spectrum combination. A total of 402 patients receiving any of the antimicrobial regimens for >48 h were evaluated retrospectively over a 2-year period (2012-2013). Patients admitted to the intensive care unit, those with a baseline serum creatinine >2.0 mg/dL, patients on haemodialysis or peritoneal dialysis, pregnant women and those in septic shock were excluded. The presence and severity of acute kidney injury (AKI) was assessed according to the AKIN criteria. The incidence of AKI was significantly higher in the TZP+VAN group (41.3%) compared with the TZP (16.0%), VAN (15.7%) and VAN+MEM (10.1%) groups (P < 0.001). In the multivariate analysis, the risk of AKI increased 3.5-fold in patients treated with TZP+VAN and 1.7-fold in those who were receiving a potentially nephrotoxic drug when the antibiotic regimen was started compared with patients treated with VAN alone. Combined use of TZP+VAN carries a much higher risk of AKI than either antibiotic monotherapy regimen. Therefore, this broad-spectrum combination should be used cautiously in patients with a high likelihood of developing kidney injury.

DOI : 10.1016/j.ijantimicag.2018.03.024

Anahtar Kelimeler : Acute kidney injury, Meropenem, Nephrotoxicity, Piperacillin/tazobactam, Vancomycin

24

Recreational Drugs and Antiretrovirals: Is It Worth the World or Trivial?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Mediterranean Journal of Infection, Microbes and Antimicrobials

Yazar(lar) :

Emre KARA , Ahmet Çağkan İNKAYA , Kutay DEMİRKAN , Serhat ÜNAL

Yıl :

2016

Serhat ÜNAL

Özet Ek Bilgiler

According to the World Health Organization, 1 out of 200 people in the world was living with Human immunodeficiency virus (HIV)/Acquired immune deficiency syndrome (AIDS) in 2015 and four new HIV infections occurred each minute. A relationship between HIV infection and recreational drug use was evident from the very beginning of the HIV epidemic. Recreational drug use is more common in patients living with HIV/AIDS compared to others. Needle-sharing activities, psychological and cognitive consequences of the abused substances facilitate new infections. It is assumed that 1.650.000 individuals were infected with HIV out of 12.190.000 intravenous drug users in 158 countries in 2013. Cytochrome isoenzymes (i.e. CYP3A4, CYP2D6) are responsible from metabolism of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors and chemokine receptor 5 inhibitors as well as recreational drugs. Recreational and antiretroviral drugs (ARV) may share the same metabolic pathways resulting in drug interactions. Drug interactions may occur because of pharmacodynamic and pharmacokinetic properties of the drugs. Induction of CYP3A4 (due to cocaine, tobacco, chronic alcohol use, etc.) may lead to decreased antiretroviral treatment (ART) effectiveness and increased risk of metabolites-related toxicity, however, inhibition of CYP3A4 (due to marijuana, acute alcohol use, etc.) may lead to increased side effects and drug toxicity. The feeling of moving away from reality and reduction of social pressure associated with recreational drugs mean all the world to the user. However, drug interaction risk makes it challenging for the physicians, when it is time for the selection of ARV. Therefore, physicians’ awareness on the interaction of these drugs is very important. Interactions with recreational drugs should be considered when prescribing ART for these patients. Integrase inhibitors and nucleoside/nucleotide reverse transcriptase inhibitors are safe to use in these circumstances. In this paper, drug interactions between ARV and alcohol, benzodiazepines, opiates, cocaine, methamphetamine, ecstasy, lysergic acid diethylamide, ketamine, gamma hydroxylbutyrate, marihuana, and phencyclidine are reviewed.

DOI : 10.4274/mjima.2016.11

Anahtar Kelimeler : Recreational drugs, antiretroviral drugs, drug interactions, Human immunodeficiency virus, drug metabolism

ISSN: 2147-673X
Cilt: 5

Sınıflandırma :

Biyotıp %100

Farmakoloji ve Toksikoloji %95

25

Aminoglycoside Resistance Mechanisms in Gram-Negative Bacteria: Recent Developments and the Results of the Turkish Survey

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Ufuk ÖVER , Deniz GÜR , Serhat ÜNAL , George H. MILLER

Yıl :

2000

Serhat ÜNAL

Özet Ek Bilgiler

Resistance mechanisms of gram-negative bacteria to aminoglycoside antibiotics differs by region and country. Aminoglycoside resistance mechanisms (Ag RMs) in gram-negative isolates resistant to either one of gentamicin (G), tobramycin (T), netilmicin (N) and amikacin (A) collected in different regions of Turkey were determined by both phenotyping and genotyping methods. Phenotyping was performed on the basis of relative resistance profiles of the isolates to 12 aminoglycoside antibiotics. Genotypically, Ag RMs of the isolates were determined by using hybridization assay including 22 common aminoglycoside resistance gene probes. Among 585 aminoglycoside-resistant gram-negative bacteria, resistance rates were highest for gentamicin (91.5%) followed by tobramycin (93.2%), netilmicin (62.1%), and amikacin (48.2%). Although isepamicin (I) was the most active aminoglycoside in-vitro against gram-negative bacteria, resistance rate (29.2%) for this drug was higher than in most of the other countries surveyed in earlier studies. The most common Ag RMs [AAC(3)-II (GTN), AAC(6’)-I (TNA), ANT(2”)-I (GT)] in earlier studies, were also present in this study. In addition to those mechanisms, two new mechanisms were observed. AAC(6’)-III (TNAI), occurred in both Enterobacteriaceae (11.9%) and Pseudomonas spp.(19.3%). Despite the high incidence of the other new mechanism, AAC(6’)-IV (GTNA) in Enterobacteriaceae (26.9%), it was not determined in Pseudomonas spp. All these mechanisms were mostly found in combination with each other or with less occurring resistance mechanisms except for AAC(6’)-IV which mostly occurred alone. The incidence of combinations of the most common resistance mechanisms were high in both Enterobacteriaceae (48%) and Pseudomonas spp. (58.7%). High incidence of combinations reflects the high resistance rates to clinically useful aminoglycosides (G, T, N, A, I) in gram-negative bacteria. Although enzymatic resistance mechanisms [AAC(3)-I (16.6%), AAC(6’)-II (29.3%), AAC(6’)-III (19.3%), ANT(2”)-I (40%)] were frequent in Pseudomonas spp., permeability resistance seems to be responsible for resistance to a wide range of clinically available aminoglycosides in this organism.

Anahtar Kelimeler : Aminoglycoside resistance mechanisms, Gram-negative bacteria

ISSN: 1300-932X
Cilt: 5
Sayı: 3
Sayfa: 168 - 178

Sınıflandırma :

Biyotıp %97

İlaç Direnci %92

26

PHEMA cryogel for in-vitro removal of anti-dsDNA antibodies from SLE plasma

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Materials Science and Engineering: C

Yayıncı:

Elsevier

Yazar(lar) :

Erdoğan Özgür , Nilay Bereli , Deniz Türkmen , Serhat Ünal , Adil Denizli

Yıl :

2011

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/j.msec.2011.02.012

ISSN: 0928-4931
Sayı: 5
Cilt: 31
Sayfa: 915-920

Sınıflandırma :

Kimya %100

Analitik Kimya %54

Endüstriyel Kimya ve Kimya Mühendisliği %44

27

Pathogenic antibody removal using magnetically stabilized fluidized bed

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Journal of Chromatography B

Yayıncı:

Elsevier

Yazar(lar) :

Mehmet Odabaşı , Nihal Özkayar , Serpil Özkara , Serhat Ünal , Adil Denizli

Yıl :

2005

Serhat Ünal

Ek Bilgiler

DOI : 10.1016/j.jchromb.2005.08.004

ISSN: 1570-0232
Sayı: 1-2
Cilt: 826
Sayfa: 50-57

Sınıflandırma :

Kimya %77

Kromatografi %27

28

Epidemiological Analysis of Methicillin-Resistant Staphylococcus aureus Strains Isolated From Hospital Infections by Using Arbitrarily Primed-Polymerase Chain Reaction (AP-PCR)

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

Yazar(lar) :

Serap ŞİMŞEK YAVUZ , Sesin KOCAGÖZ , Paşa GÖKTAŞ , Serhat ÜNAL

Yıl :

2001

Serhat ÜNAL

Özet Ek Bilgiler