Piri Keşif Aracı

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The dramatic improvements in basic biological research, as well as the impact of high technology, are associated with a rapid increase in life expectancy, social change and public health measures, all leading to important modifications in Medicine. In the past few years, we have seen radical changes in Medicine: we have gone from paternalism to therapeutic alliance, from treating patients to taking care of them, from the concept of disease to the concept of illness, from compliance to adherence. All this has marked the change from a medical-centred system to a patient-centred one, where patients are less passive and play an increasingly active role in their treatments (empowerment). Moreover, communication (to communicate “with” the patient and not “to” the patient) has become more relevant. In all cases, the background philosophy is “to look at things from the patient’s perspective”, who, in our case, is a child, necessarily linked to his/her parents. In the next few years we will witness a profound change in Medicine and healthcare, due to progress in technology and the ability to analyse large amounts of data from single patients. Research should be addressed towards new ambitious goals (think more and think different), but it should also look differently at old results. The winning intuition would be not just having new ideas, but finding better results in existing ones. We need more research and better research. Now it’s time to individualize our approaches in Pediatrics and Neonatology: care and cure for each and everyone.

DOI : 10.7363/010115

Anahtar Kelimeler : individualized medicine, evidence based medicine, medicine based evidence, narrative based medicine, newborn, child, u201Comicsu201D

ISSN: 2281-0692
Cilt: 1
Sayı: 1
Sayfa: 7 - 10

Sınıflandırma :

Tıp ve Halk Sağlığı %26

Uygulama ve Hastane Yönetimi %28

2

JPNIM and UENPS

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Vassilios Fanos

Yıl :

2013

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The second issue of JPNIM comes with a surprise. JPNIM has become the official journal of the Union of European Neonatal Perinatal Societies (UENPS), formed by the societies of neonatal and perinatal studies in twenty-eight European countries. JPNIM focuses on interpreting the profound changes in the world of scientific research brought about by the possibility of acquiring enormous amounts of data (“big data”) and the disposition to photograph the diagnostic, therapeutic and preventive organization of health programmes in Europe. It is not only the journal of what should be done, but of what is actually done in Europe to share, improve and harmonize knowledge in the different countries. Its international dimension is proven by the numerous contributions in this issue coming from Belgium, Bosnia and Herzegovina, Greece, Italy, Lithuania, Portugal, Sweden and Turkey. Its holistic vocation is tangible and recognizable in the passage from research to work in the field, with special emphasis on the Medical Humanities. The inclusion of the “Interview” column creates a strong bond between masters of consolidated reputation and brilliant young researchers to help make the passage from generation to generation effective and fruitful.

DOI : 10.7363/020119

Anahtar Kelimeler : uenps, union of european neonatal perinatal societies, individualized medicine, research, development, organization

ISSN: 2281-0692
Cilt: 2
Sayı: 1
Sayfa: 7 - 8

Sınıflandırma :

Kültür ve Medya Çalışmaları %28

Göç %92

3

Metabolomics, milk-oriented microbiota (MOM) and multipotent stem cells: the future of research on breast milk

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Vassilios Fanos

Yıl :

2015

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The more we learn about human milk, the more we are forced to admit to our extraordinary ignorance about this liquid, considered miraculous from ancient times. This editorial deals with three themes of great importance today: metabolomics, milk-oriented microbiota (MOM) and multipotent stem cells. Metabolomics, also called the "new clinical biochemistry”, is an approach based on the systematic study of the complete set of metabolites in a biological sample, in our case milk. Very few papers have been published on this topic. The human milk is anything but sterile! Today we know that it contains a quantity of bacteria (microbiota) of 50 genera and 200 species. The composition of human milk microbiota is highly individualized and unique for each mother and can have important effects on the colonization of the intestine and the short- and long-term health of the child. We speak of MOM. Finally, we also know that human milk contains stem cells whose function is not yet fully known. It appears that the stem cells of human milk pass through the intestinal barrier as well as that of the brain and migrate to settle in the brain and other organs and apparata, among which surely the thymus, pancreas and liver. Once they reach the neonatal tissue of destination, they appear to differentiate to assimilate and integrate in the tissue. For example, at the level of the brain stem cells from human milk may differentiate have become oligodendrocytes, astrocytes and neurons. Perhaps from the integration of knowledge in these three fields we could take further significant steps towards the understanding of the miracles of human milk.

DOI : 10.7363/040115

Anahtar Kelimeler : metabolomics, milk-oriented microbiota, multipotent stem cells, breast milk, breastfeeding, research

ISSN: 2281-0692
Cilt: 4
Sayı: 1
Sayfa: e040115 - e040115

4

10 P Pediatrics: notes for the future

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Vassilios Fanos

Yıl :

2016

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

In the last few years medicine has been changing radically, almost as a kind of metamorphosis. The final goal of this editorial, which we may call a "manifesto" that illustrates where we would like, or perhaps where we want to go, is to improve the wellbeing of each single patient rather than limiting ourselves to curing their disease. This decalogue of the change applies even more to pediatrics and will make possible the 10 P Pediatrics, as recently defined: personalized, perspective, predictive, preventive, precise, participatory, patient-centric, psycho-cognitive, postgenomic and public. In a word: individualized medicine.

DOI : 10.7363/050101

Anahtar Kelimeler : pediatrics, individualized medicine, prevention, prediction, precision medicine

ISSN: 2281-0692
Cilt: 5
Sayı: 1
Sayfa: e050101 - e050101

Sınıflandırma :

Tıp ve Halk Sağlığı %65

Tıp Felsefesi %62

5

Genital anomalies in newborns

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Journal of Perinatology

Yayıncı:

Springer Science and Business Media LLC

Yazar(lar) :

Federico Mecarini , Vassilios Fanos , Giangiorgio CrisponiFederico Mecarini , Vassilios Fanos , Giangiorgio Crisponi

Yıl :

2021

Vassilios Fanos Vassilios Fanos

Ek Bilgiler

Kaydet

DOI : 10.1038/s41372-021-00991-1

ISSN: 0743-8346
Sayı: 9
Cilt: 41
Sayfa: 2124-2133

6

Targeting aggression in severe mental illness: The predictive role of genetic, epigenetic, and metabolomic markers

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Yayıncı:

Elsevier

Yazar(lar) :

Mirko Manchia , Vassilios Fanos

Yıl :

2017

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

Human aggression is a complex and widespread social behavior that is overrepresented in individuals affected by severe mental illness (SMI), such as schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). A substantial proportion of the liability threshold for aggressive behavior is determined by genetic factors, and environmental moderators might precipitate the manifestation of this behavioral phenotype through modification of gene expression via the epigenetic machinery. These specific alterations in the genetic and epigenetic make-up of aggressive individuals might determine distinct biochemical signatures detectable through metabolomics. An additional pathophysiological component playing a role in aggressive behavior might be determined by alterations of gut microbiota. Here, we present a selective review of human data on genetic, epigenetic, and metabolomic markers of aggressive behavior in SMI, discussing also the available evidence on the role of microbiome alterations. Clinical implication of these evidences, as well as future perspectives, will be discussed.

DOI : 10.1016/j.pnpbp.2017.03.024

Anahtar Kelimeler : Schizophrenia, Bipolar disorder, Autism, Attention-deficit/hyperactivity disorder, Gene-environment interaction, Epigenetics, Metabolome, Microbiome

ISSN: 0278-5846
Cilt: 77
Sayfa: 32-41

Sınıflandırma :

Biyotıp %91

Geriatrik Psikiyatri %96

7

Antibiotics or surgery for vesicoureteric reflux in children

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

The Lancet

Yayıncı:

Elsevier

Yazar(lar) :

Vassilios Fanos , Luigi Cataldi

Yıl :

2004

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

Summary Context 1–2% of children have vesicoureteric reflux (VUR). VUR occurs in 25–40% of children with acute pyelonephritis. VUR can lead to renal scarring, hypertension, and end-stage renal disease. The best form of treatment for children with VUR is debated: no treatment, long-term antibiotic prophylaxis, surgery, or a combination of antibiotic prophylaxis and surgery. In children with recurrent urinary tract infections (UTIs) and progressive renal damage, despite antibiotic prophylaxis, surgical correction of VUR, especially high-grade VUR, is generally recommended. Starting point Danielle Wheeler and colleagues recently did a meta-analysis of ten randomised controlled trials (964 children) to evaluate whether any intervention for VUR is better than no treatment (Cochrane Database Syst Rev 2004; 3: CD001532). The main endpoints were incidence of UTIs, new or progressive renal damage, renal growth, hypertension, and glomerular filtration rate. They concluded that it is uncertain whether the identification of children with VUR is associated with clinically important benefit. The additional benefit of surgery over antibiotics is small. Where next? New strategies for management will require a tailored diagnostic and therapeutic approach, including non-invasive or less invasive diagnostic procedures, and a less aggressive therapeutic approach. Whether the common practice of cystourethrography as a first-line investigation is warranted needs evaluation. The goal of paediatricians in the future, to prevent kidney damage, will probably be prevention of renal parenchymal injury and not necessarily the correction of ureterovesical junction anomalies. Because two main clinical pictures of VUR (diagnosed prenatally or postnatally with different age and sex distribution) can be identified, boys and girls will probably be managed differently. The factors responsible for congenital and acquired renal injury in children with VUR need to be studied.

DOI : 10.1016/s0140-6736(04)17359-5

ISSN: 0140-6736
Sayı: 9446
Cilt: 364
Sayfa: 1720-1722

Sınıflandırma :

Pediatrik ameliyat %96

8

The dark side of ibuprofen in the treatment of patent ductus arteriosus: could paracetamol be the solution?

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Expert Opin Drug Metab Toxicol

Yazar(lar) :

Laura Cuzzolin , Flamina Bardanzellu , Vassilios Fanos

Konu :

Acetaminophen, Analgesics, Non-Narcotic, Anti-Inflammatory Agents, Non-Steroidal, Dose-Response Relationship, Drug, Ductus Arteriosus, Patent, Humans, Ibuprofen, Infant, Newborn, Infant, Premature

Yıl :

2018

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Patent ductus arteriosus (PDA) persistence is associated, in prematures, to several complications. The optimal PDA management is still under debate, especially regarding the best therapeutic approach and the time to treat. The available drugs are not exempt from contraindications and side effects; ibuprofen itself, although representing the first-choice therapy, can show nephrotoxicity and other complications. Paracetamol seems a valid alternative to classic nonsteroidal anti-inflammatory Drugs, with a lower toxicity. Areas covered: Through an analysis of the published literature on ibuprofen and paracetamol effects in preterm neonates, this review compares the available treatments for PDA, analyzing the mechanisms underlining ibuprofen-associated nephrotoxicity and the eventual paracetamol-induced hepatic damage, also providing an update of what has been yet demonstrated and a clear description of the still open issues. Expert Opinion: Paracetamol is an acceptable alternative in case of contraindication to ibuprofen; its toxicity, in this setting, is very low. Lower doses may be effective, with even fewer risks. In the future, paracetamol could represent an efficacious first-line therapy, although its safety, optimal dosage, and global impact have to be fully clarified through long-term trials, also in the perspective of an individualized and person-based therapy taking into account the extraordinary individual variability.

DOI : 10.1080/17425255.2018.1492550

Anahtar Kelimeler : Ibuprofen, PDA treatment, hepatotoxicity, nephrotoxicity, paracetamol

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Farmakoterapi %88

9

Renal endogenous stem cells: a new source for regenerative medicine in preterms?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Gavino Faa , Vassilios Fanos

Yıl :

2015

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The creation of new medical approaches based on stem cells to treat chronic kidney disease (CKD) and in particular end stage renal disease (ESRD) has become imperative in recent years, due to the significant burdens of patients affected by renal failure and to the limitations of dialysis and kidney transplantation to solve the problem. The initial prospective of utilizing stem cells for regenerating the affected kidney has been at the basis of excitement and hope for all patients affected by ESRD. Unfortunately, too many challenges have halted the possibility to make such regenerative approach a reality, and the vast majority of patients with CKD and renal insufficiency experience a reduced quality of life associated with high mortality. The problem appears particularly severe when ESDR develops in childhood. Children submitted to kidney transplantation have a 95% of survival rate at 5 years, but only 66% of them survive at 20 years after renal transplant. As a result, patients transplanted in childhood will need repeated renal transplants during their life. Renal regenerative medicine might experience a major renaissance in the next years, developing new methodologies stemmed from the previous attempts. Here, we present some major points to be addressed, in order to open a debate on the potential offered by the different regenerative methodologies: • the “exogenous” approach; • the “endogenous” approach; • the “therapeutic” approach; • the “prevention” approach. Proceedings of the 11th International Workshop on Neonatology and Satellite Meetings · Cagliari (Italy) · October 26th-31st, 2015 · From the womb to the adult Guest Editors: Vassilios Fanos (Cagliari, Italy), Michele Mussap (Genoa, Italy), Antonio Del Vecchio (Bari, Italy), Bo Sun (Shanghai, China), Dorret I. Boomsma (Amsterdam, the Netherlands), Gavino Faa (Cagliari, Italy), Antonio Giordano (Philadelphia, USA)

DOI : 10.7363/040224

Anahtar Kelimeler : kidney, stem cells, regenerative medicine, prevention, therapy

ISSN: 2281-0692
Cilt: 4
Sayı: 2
Sayfa: e040224 - e040224

Sınıflandırma :

Nefroloji %100

10

How could metabolomics change pediatric health?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Italian Journal of Pediatrics

Yazar(lar) :

Flaminia Bardanzellu , Vassilios Fanos

Yıl :

2020

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Abstract In the last years, ‘omics’ technologies, and especially metabolomics, emerged as expanding scientific disciplines and promising technologies in the characterization of several pathophysiological processes. In detail, metabolomics, able to detect in a dynamic way the whole set of molecules of low molecular weight in cells, tissues, organs, and biological fluids, can provide a detailed phenotypic portray, representing a metabolic “snapshot.” Thanks to its numerous strength points, metabolomics could become a fundamental tool in human health, allowing the exact evaluation of individual metabolic responses to pathophysiological stimuli including drugs, environmental changes, lifestyle, a great number of diseases and other epigenetics factors. Moreover, if current metabolomics data will be confirmed on larger samples, such technology could become useful in the early diagnosis of diseases, maybe even before the clinical onset, allowing a clinical monitoring of disease progression and helping in performing the best therapeutic approach, potentially predicting the therapy response and avoiding overtreatments. Moreover, the application of metabolomics in nutrition could provide significant information on the best nutrition regimen, optimal infantile growth and even in the characterization and improvement of commercial products’ composition. These are only some of the fields in which metabolomics was applied, in the perspective of a precision-based, personalized care of human health. In this review, we discuss the available literature on such topic and provide some evidence regarding clinical application of metabolomics in heart diseases, auditory disturbance, nephrouropathies, adult and pediatric cancer, obstetrics, perinatal conditions like asphyxia, neonatal nutrition, neonatal sepsis and even some neuropsychiatric disorders, including autism. Our research group has been interested in metabolomics since several years, performing a wide spectrum of experimental and clinical studies, including the first metabolomics analysis of human breast milk. In the future, it is reasonable to predict that the current knowledge could be applied in daily clinical practice, and that sensible metabolomics biomarkers could be easily detected through cheap and accurate sticks, evaluating biofluids at the patient’s bed, improving diagnosis, management and prognosis of sick patients and allowing a personalized medicine. A dream? May be I am a dreamer, but I am not the only one.

DOI : 10.1186/s13052-020-0807-7

Anahtar Kelimeler : Neonatology, Obstetrics, Perinatal asphyxia, Breastfeeding, Sepsis, Autism

Cilt: 46
Sayı: 1
Sayfa: 1 - 13

Sınıflandırma :

Biyotıp %80

Gen İfadesi %24

11

Human microbiome and allergy

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Pediatric Allergy and Immunology

Yazar(lar) :

Vittoria Montecchiani , Vassilios Fanos

Konu :

Immunology, Immunology and Allergy, Pediatrics, Perinatology, and Child Health

Yıl :

2020

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

Human microbiome contributes to critical functions that impact health and disease. It influences the development of the immune system, and the pathogenesis of immunological disorders included allergy. While it is easy to understand how airway microbiome, influencing local inflammation and immune activity, could contribute to shaping asthma phenotype, it is not so obvious to understand the influence by the gut microbiome, but there is growing evidence about it. The increase of allergic disorders in western countries led to investigate the role environment is playing and how it may change our microbiome and immune system, with the hope of finding new preventive approaches for allergy.

DOI : 10.1111/pai.13360

ISSN: 0905-6157
Sayı: S26
Cilt: 31
Sayfa: 5-7

12

Metabolomics, Microbiomics, Machine learning during the COVID‐19 pandemic

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Pediatric Allergy and Immunology

Yazar(lar) :

Flaminia Bardanzellu , Vassilios Fanos

Yıl :

2022

Vassilios Fanos

Yayıncı Web Siteleri

Ek Bilgiler

Kaydet

Kaynak 1:

http://dx.doi.org/10.1111/pai.13640 arayıcılığı görüntüle.
Kaynak 2:

http://dx.doi.org/10.1111/pai.13640 arayıcılığı görüntüle.

DOI : 10.1111/pai.13640

ISSN: 0905-6157
Sayı: S27
Cilt: 33
Sayfa: 86-88

13

Treatment-based literature of Henoch–Schönlein purpura nephritis in childhood

Dergi Makalesi

Kaynak :

Springer Link

Dergi:

Pediatric Nephrology

Yazar(lar) :

Marco Zaffanello , Vassilios Fanos

Konu :

Nephrology, Pediatrics, Perinatology, and Child Health

Yıl :

2009

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

Considerable concern has been expressed on the importance of identifying an improved therapeutic protocol for use in the treatment of childhood Henoch–Schönlein purpura nephritis, primarily due to the unpredictable success shown to date in improving long-term renal outcome. This review focuses on published reports describing the outcomes of therapeutic approaches currently being used in the treatment of pediatric Henoch–Schönlein purpura nephritis, with the aim of providing information that will facilitate a treatment-based approach in children presenting with varying degrees of kidney disease. The conclusions of the authors of this review are that currently prescribed treatments of children affected by Henoch–Schönlein purpura nephritis are not adequately guided by evidence obtained in properly designed, randomized, placebo-controlled trials with outcome markers related to the progression to end stage renal disease (level I evidence). Moreover, firm evidence supporting the best practice to be applied with the aim of delaying the progression of kidney disease is still lacking.

DOI : 10.1007/s00467-008-1066-9

Anahtar Kelimeler : Children, Evidence-based approach, Glomerulonephritis, Henochu2013Schönlein purpura

ISSN: 0931-041X 1432-198X
Sayı: 10
Cilt: 24
Sayfa: 1901-1911

14

David Barker: the revolution that anticipates existence

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Italo Farnetani , Vassilios Fanos

Yıl :

2014

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

David Barker is the man who “anticipated" the existence of babies by focusing attention on the importance of the fetus and what takes place during intrauterine life. Barker was one of the physicians who in the last decades brought about the greatest changes in medicine, changes so important as to represent a veritable revolution in medical thought. According to Barker's studies, the embryo obviously has a genetic complement coming from the mother and father, but from the very first stages of development it begins to undergo the influence of the outside environment, just as occurs for adults whose biological, psychological and pathological aspects are influenced by the environment to a not well-established percentage between genetic complement and epigenetics. Much of our future lives as adults is decided in our mothers' wombs. If Barker's discovery was revolutionary from the cultural standpoint, it was even more so from the strictly medical one. Barker's research method was rigid from the methodological standpoint, but innovative and speculative in its working hypotheses, with a humanistic slant. Barker's idea has another practical corollary: it is evident that the role of obstetricians, perinatologists and neonatologists is more and more relevant in medicine and future prevention. Unquestionably, besides the enormous merits of his clinical research, among the benefits that Barker has contributed there is that of having helped us to see things from new points of view. Not only is the neonate (and even more so the fetus) not an adult of reduced proportions, but perhaps the neonate is the "father" of the adult person.

DOI : 10.7363/030111

Anahtar Kelimeler : david barker, barkeru2019s revolution, fetus, intrauterine life, perinatal programming

ISSN: 2281-0692
Cilt: 3
Sayı: 1
Sayfa: e030111 - e030111

Sınıflandırma :

Kültür ve Medya Çalışmaları %63

15

Developmental programming of auditory learning

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Melania Puddu , Vassilios Fanos

Yıl :

2012

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The basic structures involved in the development of auditory function and consequently in language acquisition are directed by genetic code, but the expression of individual genes may be altered by exposure to environmental factors, which if favorable, orient it in the proper direction, leading its development towards normality, if unfavorable, they deviate it from its physiological course. Early sensorial experience during the foetal period (i.e. intrauterine noise floor, sounds coming from the outside and attenuated by the uterine filter, particularly mother’s voice) and modifications induced by it at the cochlear level represent the first example of programming in one of the earliest critical periods in development of the auditory system. This review will examine the factors that influence the developmental programming of auditory learning from the womb to the infancy. In particular it focuses on the following points: • the prenatal auditory experience and the plastic phenomena presumably induced by it in the auditory system from the basilar membrane to the cortex; • the involvement of these phenomena on language acquisition and on the perception of language communicative intention after birth; • the consequences of auditory deprivation in critical periods of auditory development (i.e. premature interruption of foetal life).

DOI : 10.7363/010111

Anahtar Kelimeler : auditory, experience, learning, deprivation, prosodic, voice processing

ISSN: 2281-0692
Cilt: 1
Sayı: 1
Sayfa: 59 - 66

Sınıflandırma :

Biyotıp %55

Nörobiyoloji %100

16

Metabolomics: a challenge for detecting and monitoring inborn errors of metabolism.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Ann Transl Med

Yazar(lar) :

Michele Mussap , Marco Zaffanello , Vassilios Fanos

Yıl :

2018

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Timely newborn screening and genetic profiling are crucial in early recognition and treatment of inborn errors of metabolism (IEMs). A proposed nosology of IEMs has inserted 1,015 well-characterized IEMs causing alterations in specific metabolic pathways. With the increasing expansion of metabolomics in clinical biochemistry and laboratory medicine communities, several research groups have focused their interest on the analysis of metabolites and their interconnections in IEMs. Metabolomics has the potential to extend metabolic information, thus allowing to achieve an accurate diagnosis for the individual patient and to discover novel IEMs. Structural and functional information on 247 metabolites associated with 147 IEMs and 202 metabolic pathways involved in various IEMs have been reported in the human metabolome data base (HMDB). For each metabolic gene, a new computational approach can be developed for predicting a set of metabolites, whose concentration is predicted to change after gene knockout in urine, blood and other biological fluids. Both targeted and untargeted mass spectrometry (MS)-based metabolomic approaches have been used to expand the range of disease-associate metabolites. The quantitative targeted approach, in conjunction with chemometrics, can be considered a basic tool for validating known diagnostic biomarkers in various metabolic disorders. The untargeted approach broadens the identification of new biomarkers in known IEMs and allows pathways analysis. Urine is an ideal biological fluid for metabolomics in neonatology; however, the lack of standardization of preanalytical phase may generate potential interferences in metabolomic studies. The integration of genomic and metabolomic data represents the current challenge for improving diagnosis and prognostication of IEMs. The goals consist in identifying both metabolically active loci and genes relevant to a disease phenotype, which means deriving disease-specific biological insights.

DOI : 10.21037/atm.2018.09.18

Anahtar Kelimeler : Inborn errors of metabolism (IEMs), genomics, inherited metabolic diseases, metabolic pathways, metabolome, metabolomics, newborn screening national programs, urine

Sınıflandırma :

Biyotıp %99

Metabolik Hastalıklar %100

17

Pediatric obesity: could metabolomics be a useful tool?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Angelica Dessì , Vassilios Fanos

Yıl :

2013

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Pediatric obesity represents an important health issue. In recent years applications of metabolomics have led to evaluation of responses to the various nutrients (nutrigenomics), in particular to lipids, in diseases such as obesity and diabetes. The experimental data and the studies in pediatrics that evaluated the metabolic condition in infant obesity are presented. It is thus to be hoped that future progress in connection with this new technique, together with a metabolomic study of mother's milk and formula milk, will lead to the creation of better personalized nutritional therapies to prevent infantile obesity and the chronic pathologies of adults connected with it.

DOI : 10.7363/020205

Anahtar Kelimeler : metabolomics, obesity, children, prevention

ISSN: 2281-0692
Cilt: 2
Sayı: 2
Sayfa: e020205 - e020205

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Klinik Beslenme %79

18

The Human Breast Milk Metabolome in Preeclampsia, Gestational Diabetes, and Intrauterine Growth Restriction: Implications for Child Growth and Development

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

The Journal of Pediatrics

Yayıncı:

Elsevier

Yazar(lar) :

Flaminia Bardanzellu , Melania Puddu , Vassilios Fanos

Yıl :

2020

Vassilios Fanos

Ek Bilgiler

Kaydet

DOI : 10.1016/j.jpeds.2020.01.049

Anahtar Kelimeler : Great obstetrical syndromes, breastfeeding, metabolomics, AGA Appropriate for gestational age, Appropriate for gestational age, IUGR Intrauterine growth restriction, Intrauterine growth restriction, SGA Small for gestational age, Small for gestational age

ISSN: 0022-3476
Cilt: 221
Sayfa: S20-S28

Sınıflandırma :

Tıp ve Halk Sağlığı %51

Kadın Hastalıkları ve Perinatoloji ve Ebelik %58

Anne ve Çocuk Sağlığı %24

Biyotıp %49

Gen Fonksiyonu %43

19

Anomalies of the oral cavity in newborns

Dergi Makalesi

Kaynak :

Springer Nature

Dergi:

Journal of Perinatology

Yayıncı:

Springer Nature

Yazar(lar) :

Federico Mecarini , Vassilios Fanos , Giangiorgio Crisponi

Konu :

Paediatrics, Physical examination

Yıl :

2020

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

Examination of the oral cavity should be an essential part of the newborn assessment. Early detection of congenital disorders is essential to begin appropriate medical or surgical therapy and to prevent complications that could profoundly affect a child’s life. The present review aims to describe the main anomalies of the oral cavity in infants and provide images in order to help the physician in current clinical practice.

DOI : 10.1038/s41372-019-0585-5

ISSN: 1476-5543
Cilt: 40
Sayı: 3
Sayfa: 359-368

Sınıflandırma :

Ağız ve Çene Cerrahisi %34

Diş Hekimliği %23

20

Lactoferrin is an important factor when breastfeeding and COVID‐19 are considered

Dergi Makalesi

Kaynak :

Wiley Online Library

Dergi:

Acta Paediatrica

Yazar(lar) :

Diego G. Peroni , Vassilios Fanos

Konu :

Pediatrics, Perinatology, and Child Health, General Medicine

Yıl :

2020

Vassilios Fanos

Ek Bilgiler

Kaydet

DOI : 10.1111/apa.15417

ISSN: 0803-5253
Sayı: 10
Cilt: 109
Sayfa: 2139-2140

21

Human Breast Milk-Acquired Cytomegalovirus Infection: Certainties, Doubts And Perspectives.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Curr Pediatr Rev

Yazar(lar) :

Flaminia Bardanzellu , Vassilios Fanos , Alessandra Reali

Yıl :

2018

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Breast Milk (BM) is the best source of nutrition for newborns, especially if premature. In fact, its beneficial impact on short- and long-term neonatal outcome has was deeply described. Unfortunately, BM could not be always so safe, especially due to the possible presence of maternal viruses that can shed and transferred to the breastfed neonate. Among these, Cytomegalovirus (CMV) can potentially lead to a serious and acute illness, mostly in case of low gestational age. Some studies also report the association of CMV-acquired infection to an increased risk of structural and functional brain modifications and neurological impairment. Due to these reasons, a strategy to remove CMV from BM with a minimal or absent impact on its beneficial components, would be desirable. Up to now, pasteurization, freezing, ultraviolet- C or microwave irradiation are the available techniques; they show different levels of efficacy and variable effects on BM composition, even if many studies are still needed to fully clarify these implications. In this review, we provide an update of the current evidence about these topics. We focus on the factors promoting CMV shedding through BM; moreover, the possible occurrence of a severe disease in preterm neonates is also described. Finally we investigate the potential effects showed on BM properties by the strategies that prevent or reduce viral transmission, therefore influencing newborns' healthy, and the new techniques which could show a relevant role in the next future, such as metabolomics.

DOI : 10.2174/1573396315666181126105812

Anahtar Kelimeler : Breast Milk, Cytomegalovirus, Freezing, Irradiation., Pasteurization, Preterm newborns

Sınıflandırma :

Tıp ve Halk Sağlığı %51

Anne ve Çocuk Sağlığı %31

Biyotıp %45

Metabolik Hastalıklar %39

Hematoloji %28

22

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Nutrients

Yazar(lar) :

Flaminia Bardanzellu , Vassilios Fanos , Alessandra Reali

Yıl :

2017

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Human Milk (HM) is the best source for newborn nutrition until at least six months; it exerts anti-inflammatory and anti-infective functions, promotes immune system formation and supports organ development. Breastfeeding could also protect from obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) presents a peculiar role in newborn support as a protective effect against allergic and chronic diseases, in addition to long-term metabolic benefits. In this review, we discuss the recent literature regarding “omics” technologies and growth factors (GF) in HC and the effects of pasteurization on its composition. Our aim was to provide new evidence in terms of transcriptomics, proteomics, metabolomics, and microbiomics, also in relation to maternal metabolic diseases and/or fetal anomalies and to underline the functions of GF. Since HC results are so precious, particularly for the vulnerable pre-terms category, we also discuss the importance of HM pasteurization to ensure donated HC even to neonates whose mothers are unable to provide. To the best of our knowledge, this is the first review analyzing in detail the molecular pattern, microbiota, bioactive factors, and dynamic profile of HC, finding clinical correlations of such mediators with their possible in vivo effects and with the consequent impact on neonatal outcomes.

DOI : 10.3390/nu9080843

Anahtar Kelimeler : omics technologies, human colostrum, transcriptomics, proteomics, metabolomics, microbiomics, growth factors, pasteurization, preterm newborns, neonatal intensive unit care

ISSN: 2072-6643
Cilt: 9
Sayı: 8
Sayfa: 843

Sınıflandırma :

Biyotıp %78

Gıda Mikrobiyolojisi %26

Tıp ve Halk Sağlığı %20

Anne ve Çocuk Sağlığı %74

23

Probiotics and the skin

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinics in Dermatology

Yayıncı:

Elsevier

Yazar(lar) :

Giuseppe Caramia , Alessandra Atzei , Vassilios Fanos

Yıl :

2008

Vassilios Fanos

Özet Ek Bilgiler

Kaydet

A review of the relationships between probiotics and the skin is presented. After a brief historical introduction, the main pathophysiological data on intestinal microflora, the immune system and the skin are presented. Clinical studies with probiotics in atopic children are discussed in detail. Many experimental studies have found that probiotics exert specific effects in the luminal lumen and on epithelial cells and immune cells with antiallergic potential. Not all probiotics have the same immunological properties. Moreover, although rarely, complications of probiotic use can occur and must be known and taken into account. This review underlines the potential interest in probiotics for the management of skin pathology.

DOI : 10.1016/j.clindermatol.2007.10.008

ISSN: 0738-081X
Sayı: 1
Cilt: 26
Sayfa: 4-11

Sınıflandırma :

Tamamlayıcı ve Alternatif İlaç %84

24

Stem cell markers in the heart of the human newborn

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Armando Faa , Elvira Podda , Vassilios Fanos

Yıl :

2016

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The identification of cardiac progenitor cells in mammals raises the possibility that the human heart contains a population of stem cells capable of generating cardiomyocytes and coronary vessels. Several recent studies now show that the different cell types that characterize the adult human heart arise from a common ancestor. Human cardiac stem cells differentiate into cardiomyocytes, and, in lesser extent, into smooth muscle and endothelial cells. The characterization of human cardiac stem cells (CSCs) has important clinical implications. In recent years, CD117 (c-kit) has been reported to mark a subtype of stem/progenitor cells in the human heart, with stem cell-like properties, including the ability to self-renewal and clonogenicity multipotentiality. Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano

DOI : 10.7363/050204

Anahtar Kelimeler : stem cell, markers, heart, newborn

ISSN: 2281-0692
Cilt: 5
Sayı: 2
Sayfa: e050204 - e050204

Sınıflandırma :

Biyotıp %89

Kardiyovasküler Biyoloji %70

25

Past and future of stem cells: from Prometheus to regenerative medicine

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Gavino Faa , Vassilios Fanos , Antonio Giordano

Yıl :

2016

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

The salamander limb regenerates completely after amputation and the heart of the zebrafish returns to normal even after an extensive injury. What is it that makes all this possible? The answer is the presence of stem cells, which in these animals are quite efficient. We humans have lost this capacity, but researchers are working incessantly to control cell reprogramming and make regenerative medicine possible and close at hand. It is probable that the ancient Greeks knew about the regenerative properties of the liver. Suffice it to recall the story of Prometheus. Different organs are considered: brain, heart, lung, kidney, adrenal glands, liver, pancreas, gut. Last but not least, we consider the stem cells of mother's milk which, from the neonatal intestinal lumen, are transported to the several organs, among which the brain, in which they become neurons, oligodendrocytes and astrocytes. This is a discovery that changes many things with respect to our knowledge today. Many actors are present on the stage in the archipelago of complexity and the uninterrupted string of perinatal programming which, from fetus to adult, orients and governs our health, for better or for worse. Proceedings of the 2nd International Course on Perinatal Pathology (part of the 11th International Workshop on Neonatology · October 26th-31st, 2015) · Cagliari (Italy) · October 31st, 2015 · Stem cells: present and future Guest Editors: Gavino Faa, Vassilios Fanos, Antonio Giordano

DOI : 10.7363/050234

Anahtar Kelimeler : stem cells, regenerative medicine, brain, heart, kidney, adrenal glands, liver, pancreas

ISSN: 2281-0692
Cilt: 5
Sayı: 2
Sayfa: e050234 - e050234

Sınıflandırma :

Biyotıp %80

Popüler Yaşam Bilimleri %33

26

Scale-free networks in metabolomics.

Dergi Makalesi

Kaynak :

PubMed

Dergi:

Bioinformation

Yazar(lar) :

Hema Sekhar Reddy Rajula , Matteo Mauri , Vassilios Fanos

Yıl :

2018

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Metabolomics is an expanding discipline in biology. It is the process of portraying the phenotype of a cell, tissue or species organism using a comprehensive set of metabolites. Therefore, it is of interest to understand complex systems such as metabolomics using a scale-free topology. Genetic networks and the World Wide Web (WWW) are described as networks with complex topology. Several large networks have vertex connectivity that goes beyond a scale-free power-law distribution. It is observed that (a) networks expand constantly by the addition of recent vertices, and (b) recent vertices attach preferentially to sites that are already well connected. Scalefree networks are determined with precision using vital features such as a structure, a disease and a patient. This is pertinent to the understanding of complex systems such as metabolomics. Hence, we describe the relevance of scale-free networks in the understanding of metabolomics in this article.

DOI : 10.6026/97320630014140

Anahtar Kelimeler : complex systems, metabolites, metabolomics, modelling, pathways, scale-free networks

Sınıflandırma :

Biyotıp %45

Gen İfadesi %22

Bilgisayar Bilimi %23

Hesaplamalı Biyoloji ve Biyoinformatik %99

27

Laboratory medicine meets precision medicine: The paradigm of metabolomics in perinatology

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

Clinica Chimica Acta

Yayıncı:

Elsevier

Yazar(lar) :

Michele Mussap , Maurizio Ferrari , Vassilios Fanos

Yıl :

2015

Vassilios Fanos

Ek Bilgiler

Kaydet

DOI : 10.1016/j.cca.2015.08.025

Anahtar Kelimeler : Precision medicine, Perinatal programming, Metabolomics, Next-generation DNA sequencing, Genomics, Gut microbiota

ISSN: 0009-8981
Cilt: 451
Sayfa: 1-3

Sınıflandırma :

Tıp ve Halk Sağlığı %89

28

Coronavirus disease 2019, Kawasaki disease, and multisystem inflammatory syndrome in children

Dergi Makalesi

Kaynak :

Science Direct

Dergi:

The Journal of Pediatrics

Yayıncı:

Elsevier

Yazar(lar) :

Pier Paolo Bassareo , Giuseppe Calcaterra , Vassilios Fanos

Yıl :

2020

Vassilios Fanos

Ek Bilgiler

Kaydet

DOI : 10.1016/j.jpeds.2020.06.033

ISSN: 0022-3476
Cilt: 224
Sayfa: 184

Sınıflandırma :

Pediatri %94

29

Congenital ocular anomalies in newborns: a practical atlas

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Journal of Pediatric and Neonatal Individualized Medicine

Yazar(lar) :

Federico Mecarini , Vassilios Fanos , Giangiorgio Crisponi

Yıl :

2020

Vassilios Fanos

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

All newborns should be examined for ocular structural abnormalities, an essential part of the newborn assessment. Early detection of congenital ocular disorders is important to begin appropriate medical or surgical therapy and to prevent visual problems and blindness, which could deeply affect a child’s life. The present review aims to describe the main congenital ocular anomalies in newborns and provide images in order to help the physician in current clinical practice.

DOI : 10.7363/090207

ISSN: 2281-0692
Cilt: 9
Sayı: 2
Sayfa: e090207 - e090207

Sınıflandırma :