• Piri Keşif Aracı

Arama ipuçları nelerdir?
1.  sayfa ve
1
Current Approaches in NSCLC Targeting K-RAS and EGFR
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
MDPI
Dergi:
International Journal of Molecular Sciences
Yayıncı:
MDPI AG
Yazar(lar) :
Veronica Aran , Jasminka Omerovic
Yıl :
2019
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The research and treatment of non-small cell lung cancer (NSCLC) have achieved some important advances in recent years. Nonetheless, the overall survival rates for NSCLC remain low, indicating the importance to effectively develop new therapies and improve current approaches. The understanding of the function of different biomarkers involved in NSCLC progression, survival and response to therapy are important for the development of early detection tools and treatment options. Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (K-RAS) are two of the main significant biomarkers for the management of NSCLC. Mutations in these genes were associated with development and response to therapies. For example, the use of small molecule tyrosine kinase (TK) inhibitors and immunotherapy has led to benefits in some, but not all patients with altered EGFR. In contrast, there is still no effective approved drug to act upon patients harbouring K-RAS mutations. In addition, K-RAS mutations have been associated with lack of activity of TK inhibitors. However, promising approaches aimed to inhibit mutant K-RAS are currently under study. Therefore, this review will discuss these approaches and also EGFR therapies, and hopefully, it will draw attention to the need of continued research in the field in order to improve the outcomes in NSCLC patients.
DOI : 10.3390/ijms20225701
ISSN: 1422-0067
Sayı: 22
Cilt: 20
Sayfa: 5701
Sınıflandırma :
2
Compartmentalized Ras signaling differentially contributes to phenotypic outputs
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Cellular Signalling
Yayıncı:
Elsevier
Yazar(lar) :
Veronica Aran , Ian A. Prior
Yıl :
2013
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Ras isoforms are membrane bound proteins that differentially localize to the plasma membrane and subcellular compartments within the cell. Whilst the cell surface is the main site for Ras activity the extent to which intracellular pools contribute to Ras function is debated. We have generated Ras chimeras targeting Ras to the ER, Golgi, mitochondria and endosomes to compare the capacity of each of these locations to support activity equivalent to normal Ras function. We find that all locations are capable of regulating the MAP kinase and Akt pathways. Furthermore, whilst endomembranous Ras pools show location-specific competence to support proliferation and transformation, Golgi-Ras is as potent as N-Ras.
DOI : 10.1016/j.cellsig.2013.05.004
Anahtar Kelimeler : Ras, Organelle, Golgi, Endomembrane, Transformation, Signaling
ISSN: 0898-6568
Sayı: 9
Cilt: 25
Sayfa: 1748-1753
Sınıflandırma :
3
Regulation of SNARE-dependent fusion in an in vitro system
Tez

Tez
Open Access
Kaynak :
The Dart-Europe
Dergi:
University of Glasgow
Yazar(lar) :
Veronica Aran-Ponte
Yıl :
2009
Veronica Aran-Ponte
Yayıncı Web Sitesi
Kaydet Alıntıla
Sınıflandırma :
4
Colorectal Cancer: Epidemiology, Disease Mechanisms and Interventions to Reduce Onset and Mortality
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Clinical Colorectal Cancer
Yayıncı:
Elsevier
Yazar(lar) :
Veronica Aran , Ana Paula Victorino , Luiz Claudio Thuler , Carlos Gil Ferreira
Yıl :
2016
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Colorectal cancer (CRC) is a multifactorial disease resulting from lifestyle, genetic, and environmental factors. There are hereditary and non-hereditary CRC types; however, the majority are non-hereditary and mainly caused by somatic mutations in response to environmental factors. In past years, researchers have focused their attention on the mechanisms behind these factors and the methods of improving disease prevention and treatment. Improving the awareness of the population with regard to the benefits of a healthy lifestyle, including a balanced diet associated with exercise, could globally reduce CRC risk. The present review aims to address the current knowledge on CRC, taking into consideration the common molecular alterations upon different environmental and non-environmental factors, current and promising treatment interventions, and how all these factors may interact to positively or negatively influence CRC risk.
DOI : 10.1016/j.clcc.2016.02.008
Anahtar Kelimeler : Colorectal cancer incidence, Genetics, Prevention, Risk factors, Treatment
ISSN: 1533-0028
Sayı: 3
Cilt: 15
Sayfa: 195-203
Sınıflandırma :
5
Negative Regulation of Syntaxin4/SNAP-23/VAMP2-Mediated Membrane Fusion by Munc18c In Vitro
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
PLOS - Public Library of Science
Dergi:
Public Library of Science
Yazar(lar) :
Gwyn W. Gould , Nia J. Bryant , James A. McNew , Avani Verma , Veronica Aran , Fiona M. Brandie
Yıl :
2008
Veronica Aran
Tam Metin
Kaydet Alıntıla
Background Translocation of the facilitative glucose transporter GLUT4 from an intracellular store to the plasma membrane is responsible for the increased rate of glucose transport into fat and muscle cells in response to insulin. This represents a specialised form of regulated membrane trafficking. Intracellular membrane traffic is subject to multiple levels of regulation by conserved families of proteins in all eukaryotic cells. Notably, all intracellular fusion events require SNARE proteins and Sec1p/Munc18 family members. Fusion of GLUT4-containing vesicles with the plasma membrane of insulin-sensitive cells involves the SM protein Munc18c, and is regulated by the formation of syntaxin 4/SNAP23/VAMP2 SNARE complexes. Methodology/Principal Findings Here we have used biochemical approaches to characterise the interaction(s) of Munc18c with its cognate SNARE proteins and to examine the role of Munc18c in regulating liposome fusion catalysed by syntaxin 4/SNAP23/VAMP2 SNARE complex formation. We demonstrate that Munc18c makes contacts with both t- and v-SNARE proteins of this complex, and directly inhibits bilayer fusion mediated by the syntaxin 4/SNAP23/VAMP2 SNARE complex. Conclusion/Significance Our reductionist approach has enabled us to ascertain a direct inhibitory role for Munc18c in regulating membrane fusion mediated by syntaxin 4/SNAP23/VAMP2 SNARE complex formation. It is important to note that two different SM proteins have recently been shown to stimulate liposome fusion mediated by their cognate SNARE complexes. Given the structural similarities between SM proteins, it seems unlikely that different members of this family perform opposing regulatory functions. Hence, our findings indicate that Munc18c requires a further level of regulation in order to stimulate SNARE-mediated membrane fusion.
DOI : 10.1371/journal.pone.0004074
Anahtar Kelimeler : Membrane fusion, Membrane proteins, Liposomes, Vesicles, Lipids, Vesicle fusion, Cell membranes, Biocatalysis
Sınıflandırma :
Nörokimya %100
6
Cancer research in Brazil: Analysis of funding criteria and possible consequences
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Cancer Policy
Yayıncı:
Elsevier
Yazar(lar) :
William de Oliveira Avellar , Andreia Cristina de Melo , Cecilia Ferreira da Silva , Veronica Aran
Yıl :
2019
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Cancer has high incidence in both developed and developing countries. Epidemiological data on the rate of cancer incidence in Brazil appears not to have a strong impact on government policies to fund research and innovation in health, particularly in oncology. This study aimed to verify this suspicion by retrospectively analysing data from the Brazilian government’s Financier of Studies and Projects (Financiadora de Estudos e Projetos, FINEP) and The National Institute of Industrial Property (Instituto Nacional da Propriedade Industrial, INPI) on cancer research and innovation in Brazil from 1998 to 2013. Our results indicated that, in the study period, the increased rate of cancer incidence in Brazil was not accompanied by government funding for cancer research since only 9% of the budget approved to health research, and innovation, was spent on cancer research. In addition, the number of projects approved for developing infrastructure to support cancer research was limited, corresponding to 0.46% of the total budget. The number of applications for registration of patents of chemical and biotechnological drugs for cancer showed a reduction, reflecting the low investment in oncology. In conclusion, there are deficits in governmental funding of cancer research and innovation in Brazil. Therefore, effective measures to coordinate funding policies and effective criteria for funding allocation should be implemented to avoid further negative consequences for the population and the public health scenario. Moreover, increased governmental and non-governmental funding could help to improve the current precarious situation that limits the population’s access to health goods and services.
DOI : 10.1016/j.jcpo.2019.100184
Anahtar Kelimeler : Cancer, Cancer policy, Cancer research funding, Patents, Research funding criteria
ISSN: 2213-5383
Cilt: 20
Sayfa: 100184
Sınıflandırma :
7
Cancer patent scenario in Brazil: Analysis of competitive advantages
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Cancer Policy
Yayıncı:
Elsevier
Yazar(lar) :
William de Oliveira Avellar , João M. Brambati Santu2019Ana , Daniele MTP Ferreira , Flavia VG Alves , Veronica Aran , Carlos Gil Ferreira
Yıl :
2017
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The present study describes the geographical and sectorial profile of chemical and biotechnological patents, regarding prevention, diagnosis, and treatment for the most frequent cancer types in Brazil that are currently registered in the Brazilian National Institute of Industrial Property – INPI, from 1998 until 2013. The steps taken to generate competitive advantage in the Brazilian oncological drug market are discussed and an analytic sectional survey was performed using the INPI database. In addition, a literature review on technology and scientific development was conducted using the Porter’s Diamond of National Advantage model. From 503 requests for patents, 41.4% corresponded to breast cancer, 13.7% lung cancer, 38.6% prostate, and 6.4% cervical cancer. Regarding the sectors and countries involved, the vast majority (74.4%) came from the pharmaceutical industry: mainly from the USA and Switzerland. According to the analysis and the Porter Diamond Model, we concluded that Brazil is uncompetitive in cancer R&DI.
DOI : 10.1016/j.jcpo.2016.12.002
Anahtar Kelimeler : Patent, Cancer, Innovation, Health economics, Oncological drugs
ISSN: 2213-5383
Cilt: 12
Sayfa: 28-33
Sınıflandırma :
8
Cancer clinical trials in Brazil: Limitations and possibilities for health innovation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Cancer Policy
Yayıncı:
Elsevier BV
Yazar(lar) :
William de Oliveira Avellar , Héliton Spindola Antunes , Édria Aparecida Ferreira , Flávia Marília Fonseca Oliveira , Veronica Aran , Andreia Cristina de Melo
Yıl :
2021
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Background Brazil is a country of continental dimensions with great potential for the development of clinical studies across the whole territory to tackle the needs of the population. It is therefore important to obtain the national profile of clinical trials in order to identify local strengths and weaknesses in terms of productivity and study application. Thus, this paper aims to highlight the profiles of clinical studies on cancer developed and sponsored by hospitals, institutes, universities and international institutions in Brazil between 1997 and 2015. Methods This is a retrospective and analytical study in which the content analysis method of Laurence Bardin was used. Data were collected from the clinicaltrials.gov database, where 783 clinical studies on cancer prevention, diagnosis and treatment were found; 188 (24 %) of these corresponded to national initiatives and 595 (76 %) to international initiatives. Results The results show an increase in the number of national clinical studies, in particular phase III studies. There is a clear absence of national clinical studies focusing on the development of new chemical and biotechnological products in oncology. Conclusion The results indicate a regional imbalance in the distribution of national and international clinical trials. Policy summary The present study aims to improve understanding of the profile of clinical studies registered in Brazil and to draw attention to the improvements needed in the health sector's productivity to address the national demand.
DOI : 10.1016/j.jcpo.2021.100290
Anahtar Kelimeler : Cancer, Cancer research, Clinical trials, Innovation, Health policy, Research funding
ISSN: 2213-5383
Cilt: 29
Sayfa: 100290
9
Osteosarcoma, chondrosarcoma and Ewing sarcoma: Clinical aspects, biomarker discovery and liquid biopsy
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Critical Reviews in Oncology/Hematology
Yayıncı:
Elsevier BV
Yazar(lar) :
Veronica Aran , Sylvie Devalle , Walter Meohas , Manoela Heringer , Anabela Cunha Caruso , Diego Pinheiro Aguiar , Maria Eugênia Leite Duarte , Vivaldo Moura Neto
Yıl :
2021
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Bone sarcomas, although rare, are associated with significant morbidity and mortality. The most frequent primary bone cancers include osteosarcoma, chondrosarcoma and Ewing sarcoma. The treatment approaches are heterogeneous and mainly chosen based on precise tumour staging. Unfortunately, clinical outcome has not changed significantly in over 30 years and tumour grade is still the best prognosticator of metastatic disease and survival. An option to improve this scenario is to identify molecular biomarkers in the early stage of the disease, or even before the disease onset. Blood-based liquid biopsies are a promising, non-invasive way to achieve this goal and there are an increasing number of studies which investigate their potential application in bone cancer diagnosis, prognosis and personalised therapy. This review summarises the interplay between clinical and molecular aspects of the three main bone sarcomas, alongside biomarker discovery and promising applications of liquid biopsy in each tumour context.
DOI : 10.1016/j.critrevonc.2021.103340
Anahtar Kelimeler : Bone sarcomas, Osteosarcoma, Chondrosarcoma, Ewing sarcoma, Liquid biopsy
ISSN: 1040-8428
Cilt: 162
Sayfa: 103340
10
Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
European Journal of Cell Biology
Yayıncı:
Elsevier
Yazar(lar) :
Ingrid Evans-Osses , Andres Mojoli , Marta Monguió-Tortajada , Antonio Marcilla , Veronica Aran , Maria Amorim , Jameel Inal , Francesc E. Borràs , Marcel I. Ramirez
Yıl :
2017
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Giardia intestinalis (G.I), is an anaerobic protozoan and the aetiological agent of giardiasis, a diarrhoea present worldwide and associated with poverty. G.I has a simple life cycle alternating between cyst and trophozoite. Cysts are transmitted orally to the stomach and transform to trophozoites in the intestine by a multifactorial process. Recently, microvesicles (MVs) have been found to be released from a wide range of eukaryotic cells. We have observed a release of MVs during the life cycle of G.I., identifying MVs from active trophozoites and from trophozoites differentiating to the cyst form. The aim of the current work was to investigate the role of MVs from G.I in the pathogenesis of giardiasis. MVs from log phase were able to increase the attachment of G. intestinalis trophozoites to Caco-2 cells. Moreover, MVs from G. intestinalis could be captured by human immature dendritic cells, resulting in increased activation and allostimulation of human dendritic cells. Lipid rafts participate in the MV biogenesis and in the attachment to Caco-2 cells. Nevertheless, proteomic analysis from two types of MVs has shown slight differences at the protein levels. An understanding of biogenesis and content of MVs derived from trophozoites might have important implications in the pathogenesis of the disease.
DOI : 10.1016/j.ejcb.2017.01.005
Anahtar Kelimeler : Microvesicles, Parasite-host cell interactions, Innate immunity, Diarrhoea, Giardia intestinalis, Extracellular vesicles
ISSN: 0171-9335
Sayı: 2
Cilt: 96
Sayfa: 131-142
Sınıflandırma :
11
A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Lung Cancer
Yayıncı:
Elsevier
Yazar(lar) :
Veronica Aran , Pedro Masson Domingues , Fabiane Carvalho de Macedo , Carlos Augusto Moreira de Sousa , Tatiane Caldas Montella , Maria Theresa de Souza Accioly , Carlos Gil Ferreira
Yıl :
2018
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Mammalian cells differently express 4 RAS isoforms: H-RAS, N-RAS, K-RAS4A and K-RAS4B, which are important in promoting oncogenic processes when mutated. In lung cancer, the K-RAS isoform is the most frequently altered RAS protein, being also a difficult therapeutic target. Interestingly, there are two K-RAS splice variants (K-RAS4A and K-RAS4B) and little is known about the role of K-RAS4A. Most studies targeting K-RAS, or analysing it as a prognostic factor, have not taken into account the two isoforms. Consequently, the in-depth investigation of them is needed. Methods The present study analysed 98 specimens from advanced non-small cell lung cancer (NSCLC) adenocarcinoma patients originated from Brazil. The alterations present in K-RAS at the DNA level (Sanger sequencing) as well as the expression of the splicing isoforms at the RNA (qRT-PCR) and protein levels (immunohistochemistry analysis), were evaluated. Possible associations between clinicopathological features and the molecular findings were also investigated. Results Our results showed that in the non-smoking population, the cancer incidence was higher among women. In contrast, in smokers and former smokers, the incidence was higher among men. Regarding sequencing results, 10.5% of valid samples presented mutations in exon 2, being all wild-type for exon 3, and the most frequently occurring base change was the transversion G → T. Our qRT-PCR and immunohistochemical analysis showed that both, K-RAS4A and K-RAS4B, were differently expressed in NSCLC tumour samples. For example, tumour specimens showed higher K-RAS4A mRNA expression in relation to commercial normal lung control than did K-RAS4B. In addition, K-RAS4B protein expression was frequently stronger than K-RAS4A in the patients analysed. Conclusion Our results highlight the differential expression of K-RAS4A and K-RAS4B in advanced adenocarcinoma NSCLC patients and underline the need to further clarify the enigma behind their biological significance in various cancer types, including NSCLC.
DOI : 10.1016/j.lungcan.2017.12.005
Anahtar Kelimeler : Non-small cell lung cancer, K-RAS4A, K-RAS4B, Splice variants, Adenocarcinoma, Cancer patients
ISSN: 0169-5002
Cilt: 116
Sayfa: 7-14
Sınıflandırma :
12
Identification of mutant K-RAS in pituitary macroadenoma
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Pituitary
Yazar(lar) :
Veronica Aran , Manoela Heringer , Paulo Jose da Mata , Leandro Kasuki , Renan Lyra Miranda , Felipe Andreiuolo , Leila Chimelli , Paulo Niemeyer Filho , Monica Roberto Gadelha , Vivaldo Moura Neto
Konu :
Endocrinology, Endocrinology, Diabetes and Metabolism
Yıl :
2021
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
RAS genes are among the most frequently mutated genes in cancer, where their mutation frequency varies according to the distinct RAS isoforms and tumour types. Despite occurring more prevalent in malignant tumours, RAS mutations were also observed in few benign tumours. Pituitary adenomas are examples of benign tumours which vary in size and aggressiveness. The present study was performed to investigate, via liquid biopsy and tissue analysis, the presence of K-RAS mutations in a pituitary macroadenoma. Molecular analysis was performed to investigate K-RAS mutations using the droplet digital PCR (ddPCR) method by evaluating both plasma (liquid biopsy) and the solid tumour of a patient diagnosed with a giant clinically non-functioning pituitary tumour. The patient underwent surgical resection due to visual loss, and the histopathological analysis showed a gonadotrophic pituitary macroadenoma. The molecular analysis revealed the presence of mutant K-RAS both in the plasma and in the tumour tissue which, to our knowledge, has not been previously reported in the literature. Our findings highlight the exceptional capacity of the digital PCR in detecting low frequency mutations (below 1%), since we detected, for the first time, K-RAS mutations in pituitary macroadenoma. The potential impact of K-RAS mutations in these tumours should be further investigated.
DOI : 10.1007/s11102-021-01151-6
Anahtar Kelimeler : Pituitary adenoma, K-RAS, Macroadenoma, Digital PCR, Liquid biopsy
ISSN: 1386-341X 1573-7403
Sayı: 5
Cilt: 24
Sayfa: 746-753
13
KRAS mutations: variable incidences in a Brazilian cohort of 8,234 metastatic colorectal cancer patients.
e-Kitap

e-Kitap
Open Access
Kaynak :
Internet Archive Books
Dergi:
BMC Gastroenterology
Yayıncı:
BMC Gastroenterology
Yazar(lar) :
Mariano Zalis , Fernando M Vieira , Martin H Bonamino , Jonas H Salem , Ana Paula Victorino , Ilana Zalcberg-Renault , Veronica Aran , Carlos Gil Ferreira
Yıl :
2014
Veronica Aran
Tam Metin
Kaydet Alıntıla
This article is from BMC Gastroenterology, volume 14. Abstract Background: KRAS mutations are frequently found in colorectal cancer (CRC) indicating the importance of its genotyping in the study of the molecular mechanisms behind this disease. Although major advances have occurred over the past decade, there are still important gaps in our understanding of CRC carcinogenesis, particularly whether sex-linked factors play any role. Methods: The profile of KRAS mutations in the Brazilian population was analyzed by conducting direct sequencing of KRAS codons 12 and 13 belonging to 8,234 metastatic CRC patient samples. DNA was extracted from paraffin-embedded tissue, exon 1 was amplified by PCR and submitted to direct sequencing. The data obtained was analysed comparing different geographical regions, gender and age. Results: The median age was 59 years and the overall percentage of wild-type and mutated KRAS was 62.8% and 31.9%, respectively. Interestingly, different percentages of mutated KRAS patients were observed between male and female patients (32.5% versus 34.8%, respectively; p = 0.03). KRAS Gly12Asp mutation was the most prevalent for both genders and for most regions, with the exception of the North where Gly12Val was the most frequent mutation found. Conclusions: To the best of our knowledge this is one of the largest cohorts of KRAS genotyping in CRC patients and the largest to indicate a higher incidence of KRAS mutation in females compared to males in Brazil. Nevertheless, further research is required to better address the impact of gender differences in colorectal cancer.
DOI : doi:10.1186/1471-230X-14-73
Cilt :14
ISSN :1471-230X
Sınıflandırma :
14
Perspectives on emerging technologies, personalised medicine, and clinical research for cancer control in Latin America and the Caribbean
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
The Lancet Oncology
Yayıncı:
Elsevier BV
Yazar(lar) :
Gustavo Werutsky , Carlos H Barrios , Andres F Cardona , André Albergaria , Alfonso Valencia , Carlos G Ferreira , Christian Rolfo , Evandro de Azambuja , Gabriel A Rabinovich , Georgina Sposetti , Oscar Arrieta , Rodrigo Dienstmann , Taiane F Rebelatto , Valeria Denninghoff , Veronica Aran , Eduardo Cazap
Yıl :
2021
Veronica Aran
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Summary Challenges of health systems in Latin America and the Caribbean include accessibility, inequity, segmentation, and poverty. These challenges are similar in different countries of the region and transcend national borders. The increasing digital transformation of health care holds promise of more precise interventions, improved health outcomes, increased efficiency, and ultimately reduced health-care costs. In Latin America and the Caribbean, the adoption of digital health tools is in early stages and the quality of cancer registries, electronic health records, and structured databases are problematic. Cancer research and innovation in the region are limited due to inadequate academic resources and translational research is almost fully dependent on public funding. Regulatory complexity and extended timelines jeopardise the potential improvement in participation in international studies. Emerging technologies, artificial intelligence, big data, and cancer research represent an opportunity to address the health-care challenges in Latin America and the Caribbean collectively, by optimising national capacities, sharing and comparing best practices, and transferring scientific and technical capabilities.
DOI : 10.1016/s1470-2045(21)00523-4
ISSN: 1470-2045
Sayı: 11
Cilt: 22
Sayfa: e488-e500
15
Neuromechanisms of SARS-CoV-2: A Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Neuroanatomy
Yazar(lar) :
Marcos F. DosSantos , Marcos F. DosSantos , Marcos F. DosSantos , Sylvie Devalle , Veronica Aran , Daniela Capra , Daniela Capra , Daniela Capra , Natália Roberta Roque , Juliana de Mattos Coelho-Aguiar , Tânia Cristina Leite de Sampaio e Spohr , Tânia Cristina Leite de Sampaio e Spohr , Janice Gonçalves Subilhaga , Cláudia Maria Pereira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Isabella D'Andrea Meira , Paulo Niemeyer Soares Filho , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto , Vivaldo Moura-Neto
Yıl :
2020
Veronica Aran
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Recent studies have suggested the neuroinvasive potential of severe acute respiratory coronavirus 2 (SARS-CoV-2). Notably, neuroinvasiveness might be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). Some studies have demonstrated that synapse-connected routes may enable coronaviruses to access the central nervous system (CNS). However, evidence related to the presence of SARS-CoV-2 in the CNS, its direct impact on the CNS, and the contribution to symptoms suffered, remain sparse. Here, we review the current literature that indicates that SARS-CoV-2 can invade the nervous system. We also describe the neural circuits that are potentially affected by the virus and their possible role in the progress of COVID-19. In addition, we propose several strategies to understand, diagnose, and treat the neurological symptoms of COVID-19.
DOI : 10.3389/fnana.2020.00037
Anahtar Kelimeler : SARS-CoV-2, COVID-19, central nervous system, peripheral nervous system, anosmia, dysgeusia
ISSN: 1662-5129
Cilt: 14
Sınıflandırma :

Yayın Yılı

Sınırla

Doküman Türü
Tümü

Veri Tabanı
Tümü

Dergi İsmi
Tümü

Disiplin
Tümü

Disipline Göre İlgililik

Alt Disiplin
Tümü

Konu
Tümü

Yayıncı
Tümü

Lisan
Tümü

X
Filtreler