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1
British National Bibliography
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
NISCAIR Online Periodicals Repository
Dergi:
NISCAIR-CSIR, India
Yayıncı:
NISCAIR-CSIR, India
Yazar(lar) :
Wells A J
Yıl :
1957
Wells A J
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Traces the development of the BNB from its planning stage, the modifications made from time to time, and the introduction of new features. Describes the application of Indian techniques like Facet Analysis, Chain Procedure, etc. In the compilation of the BNB. Uses ‘Verbal Extension’ to DC marked by the symbol (1) to represent a subject co-extensively. Resolves some of the difficulties in applying Chain Procedure for deriving subject headings from DC due to structural defects of DC, Indicates use of non-hierarchical notation for the classification used in the British Catalogue of Music. Describes the organization, design of suitable equipment for quick and cheap copying and the mechanization of sales of the Central Card Catalogue Service of the BNB. Indicates the possibility of introducing Pre-natal Cataloguing. Gives strength of the staff, distribution of work and weekly time-table of the flow of work for the BNB.
Anahtar Kelimeler : Article

Sayfa: 73-89
ISSN: 0975-2404 (Online); 0972-5423 (Print)
2
The place of grades and standards in potato marketing
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
American Potato Journal
Yazar(lar) :
Wells A. Sherman
Konu :
Plant Science, Agronomy and Crop Science
Yıl :
1931
Wells A. Sherman
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1007/bf02875252
Anahtar Kelimeler : AMERICAN Potato Journal, Potato Crop, Early Potato, Maine Potato, Chicago Mercantile Exchange
ISSN: 0003-0589 1874-9380
Sayı: 3
Cilt: 8
Sayfa: 64-71
3
Reports and pamphles received
Dergi Makalesi

Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
National Municipal Review
Yazar(lar) :
Wells A. Gray
Yıl :
1930
Wells A. Gray
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1002/ncr.4110190213
ISSN: 0190-3799
Sayı: 2
Cilt: 19
Sayfa: 104-105
4
Role of the Rice BAHD Acyltransferase Gene OsAt10 in Plant Cold Stress Tolerance
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Plant Molecular Biology Reporter
Yazar(lar) :
Wei Tang , Wells A. Thompson
Konu :
Plant Science, Molecular Biology
Yıl :
2022
Wells A. Thompson
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The rice (Oryza sativa L.) BAHD acyltransferase gene OsAt10 affects growth and metabolism of cells and regulates cell response to environmental stress. However, influence of the OsAt10 gene on low-temperature stress tolerance has not been evaluated in plant cells. Here, cell suspension cultures of plant species Arabidopsis (Arabidopsis thaliana L.), cotton (Gossypium hirsutum L.), white pine (Pinus strobus L.), and rice (Oryza sativa L.) were used to generate transgenic cell lines via Agrobacterium tumefaciens-mediated genetic transformation to examine the effects of OsAt10 on cold stress tolerance. OsAt10 transgenic cell lines of A. thaliana, G. hirsutum, P. strobus, and O. sativa were confirmed by molecular analyses including Southern blotting ND northern blotting, following by physiological and biochemical analyses under cold stress. The experimental results demonstrated that growth rate, cell viability, lipid peroxidation, ion leakage, antioxidative enzyme activity, polyamines level, and cell morphology were changed in transgenic cells under cold stress, compared to the controls. In transgenic A. thaliana cells, overexpression of the OsAt10 gene increases expression of polyamines biosynthesis genes under cold stress. In transgenic A. thaliana plants, overexpression of the OsAt10 gene increased cold stress tolerance by regulating expression of stress marker genes, TBARS content, ion leakage level, antioxidant enzymes activity, and polyamines content, indicating that the OsAt10 gene could be economically important for improving low-temperature stress tolerance in plants.
DOI : 10.1007/s11105-021-01328-0
Anahtar Kelimeler : Genetic engineering, Low-temperature stress, Polyamines, Cell morphology
ISSN: 0735-9640 1572-9818
5
Should We Perform a New Adjuvant Trial with Bevacizumab?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Current Colorectal Cancer Reports
Yazar(lar) :
Arvind Dasari , Wells A. Messersmith
Konu :
Gastroenterology, Oncology, Hepatology
Yıl :
2011
Wells A. Messersmith
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Colorectal cancer is a major cause of cancer-related morbidity and mortality. Complete surgical resection continues to be the mainstay of treatment, followed by adjuvant chemotherapy in all stage III and selected stage II patients. Initial adjuvant clinical trials compared bio-modulated 5-fluorouracil to observation and showed significant improvements in outcomes establishing a role for adjuvant chemotherapy. Experience from subsequent trials suggests that oxaliplatin added to a fluoropyrimidine is the most active combination in the adjuvant setting. In contrast, irinotecan and cetuximab have both failed in the adjuvant setting in spite of proven activity in metastatic disease. Two recent clinical trials provide convincing evidence that bevacizumab also may not improve outcomes in the adjuvant setting. The reasons for these negative results remain unknown. Here, we discuss the results of the adjuvant bevacizumab trials and potential explanations for these findings.
DOI : 10.1007/s11888-011-0101-6
Anahtar Kelimeler : Colon cancer, Adjuvant, Chemotherapy, Bevacizumab, Fluorouracil, Capecitabine, Oxaliplatin, Angiogenesis
ISSN: 1556-3790 1556-3804
Sayı: 3
Cilt: 7
Sayfa: 218-226
Sınıflandırma :
6
Conditions required for the measurement of nitric oxide synthase activity in a myenteric plexus / smooth muscle preparation from the rat ileum
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Neuroscience Methods
Yayıncı:
Elsevier
Yazar(lar) :
Jill Lincoln , Wells A. Messersmith
Yıl :
1995
Wells A. Messersmith
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Nitric oxide synthase (NOS) activity was measured, by the conversion of arginine to eitrulline, in a preparation from the rat ileum consisting of the myenteric plexus and smooth muscle layers. A variety of incubating media were used in order to establish the optimal conditions required for the assay. NOS activity was present in the soluble fraction and was Ca2+-and calmodulin-dependent, characteristic of neuronal NOS. Exogenous Ca2+ was required for activity to be detectable but NOS activity progressively decreased with Ca2+ concentrations above 1.25 mM. Activity varied with arginine concentration, reaching saturation at 6 μM, and required the addition of the co-substrate NADPH. Endogenous levels of co-factors in the crude soluble fraction were not sufficient to maintain NOS activity. Omission of flavin adenine dinucleotide and tetrahydrobiopterin from the incubation medium reduced activity by 90%, and both co-factors had to be present for maximal activity to occur. These results emphasize the need to control assay conditions when measuring NOS activity in crude preparations from peripheral tissue.
DOI : 10.1016/0165-0270(94)00182-g
Anahtar Kelimeler : Nitric oxide synthase, Enteric nerve, Ileum, Myenteric plexus
ISSN: 0165-0270
Sayı: 2
Cilt: 59
Sayfa: 191-197
Sınıflandırma :
7
Role of the Arabidopsis calcineurin B-like protein-interacting protein kinase CIPK21 in plant cold stress tolerance
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Plant Biotechnology Reports
Yazar(lar) :
Wei Tang , Wells A. Thompson
Konu :
Plant Science, Biotechnology
Yıl :
2020
Wells A. Thompson
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The Arabidopsis calcineurin B-like protein-interacting protein kinase CIPK21 gene (AtCIPK21) plays important roles in cell metabolism, plant development, and abiotic stress responses. However, the function of the AtCIPK21 gene in cold stress tolerance in plant cells is not fully understood. In this study, we use cell cultures of three plant species including rice (Oryza sativa L.), cotton (Gossypium hirsutum L.), and white pine (Pinus strobus L.), as well as Agrobacterium tumefaciens strain GV3101 harboring pBI-AtCIPK21 to generate transgenic cell lines. After confirmation of integration of the AtCIPK21 gene into the genome by polymerase chain reaction (PCR), southern blotting, and northern blotting analyses, the rice, cotton, and pine AtCIPK21 transgenic cell lines were used to examine cold stress tolerance. The experimental results demonstrated that overexpression of the AtCIPK21 gene enhanced cold stress tolerance of transgenic cells by increasing cell viability and cell growth rate, decreasing lipid peroxidation and ion leakage, increasing the content of polyamines, as well as elevating the activity of antioxidative enzymes. In rice cells, AtCIPK21 increases expression of Ca2+-dependent protein kinase (CPK) genes and mitogen-activated protein kinase (MAPK) genes under cold stress. These results indicated that overexpression of the AtCIPK21 gene in plant cells improved cold stress tolerance by elevating polyamines content, antioxidative enzyme activity, and expression of CPK genes and MAPK genes. Overexpression of the AtCIPK21 gene may be a valuable approach for engineering plant cold stress tolerance.
DOI : 10.1007/s11816-020-00597-7
Anahtar Kelimeler : Agrobacterium-mediated transformation, AtCIPK21 gene, Cold stress, Pinus, Transgenic cell cultures
ISSN: 1863-5466 1863-5474
Sayı: 3
Cilt: 14
Sayfa: 275-291
8
Assessing Immune Response to SARS-CoV-2 Infection
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
ImmunoTargets and Therapy
Yazar(lar) :
Shurin MR , Morris A , Wells A , Wheeler SE
Yıl :
2020
Wells A
Yayıncı Web Sitesi
Kaydet Alıntıla
Michael R Shurin,1,2 Alison Morris,3 Alan Wells,1 Sarah E Wheeler1 1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 3Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USACorrespondence: Michael R Shurin Email shurinmr@upmc.eduIn the XXI century, we have already witnessed the global spread of three previously unknown coronaviruses. In 2002, the first known case of severe acute respiratory syndrome (SARS) occurred in China and SARS coronavirus (SARS-CoV) was identified in 2003.1 Before SARS pandemic was declared to be over in summer of 2003, about 8500 cases were reported, including almost 900 deaths in 32 countries. Ten years later, in 2012, a novel coronavirus, Middle East respiratory syndrome coronavirus (MERS-CoV), was isolated and was proven to be associated with several clusters of cases, first in the Arabian Peninsula and then in other countries. As a result, almost 2500 cases including more than 850 deaths in 27 countries have been reported.2 In 2019, a novel β-coronavirus caused severe and even fatal pneumonia in Wuhan China, and rapidly spread to other provinces of China and other countries in 2020. The World Health Organization (WHO) on March 11, 2020, declared coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a pandemic. By mid-May 2020, more than 300,000 people have died and over 4,000,000 have been infected by the coronavirus in almost 200 countries and territories worldwide.
Anahtar Kelimeler : sars-cov-2, covid-19, serology, coronavirus, immunodiagnostics
ISSN: 2253-1556
Cilt: 9
Sayfa: 111 - 114
Sınıflandırma :
9
Educating Future Rulers
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
JSTOR
Dergi:
The Journal of Education
Yayıncı:
Trustees of Boston University
Yazar(lar) :
WELLS A. HALL
Konu :
Social Sciences, Education
Yıl :
1932
WELLS A. HALL
Kaydet Alıntıla
Cilt: 115
Sayı: 12
Sayfa: p. 357
Yayın Tarihi: 1932-05-02
ISSN: 0022-0574
10
The Development and Present Status of Water Rights and Water Policy in the United States
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
JSTOR
Dergi:
American Journal of Agricultural Economics
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Wells A. Hutchins
Yıl :
1955
Wells A. Hutchins
Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.2307/1233960
Cilt: 37
Sayı: 5
Sayfa: 866-874
Yayın Tarihi: 1955-12-01
11
The Community Acequia: Its Origin and Development
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
The Southwestern Historical Quarterly
Yayıncı:
Texas State Historical Association
Yazar(lar) :
Wells A. Hutchins
Konu :
American Studies, Area Studies, History
Yıl :
1928
Wells A. Hutchins
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 31
Sayı: 3
Sayfa: pp. 261-284
Yayın Tarihi: 1928-01-01
ISSN: 0038-478X
12
EIGHT OR NINE GRADES?
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
The Journal of Education
Yayıncı:
Trustees of Boston University
Yazar(lar) :
Wells A. Hall
Konu :
Social Sciences, Education
Yıl :
1910
Wells A. Hall
Yayıncı Web Sitesi
Kaydet Alıntıla
612 JOURNAL OF EDUCATION December J 5, 1910 EIGHT OR NINE GRADES? My dear Mr. Winship: In the Journal of November 24, 1910, I read this: "No elementary school course should have more than eight grades " Presum- ably this is a general belief among educators. I will not attempt to deny the soundness of this state- ment. I wish only to call attention to some facts which seem to contradict it. I believe we may fairly mat* the following assumptions: (a) By elementary school course is meant a course which prepares pupils for entrance to a good modern high school; (b) the pub- lic elementary school course is intended for all normal children: (c) any such course which the average normal child cannot complete in the time allotted is too full, or the time allotted is not enough; (d) repeating a grade or grades is discouraging to any pupil, and all too often disastrous. If these assumptions are justified, and if the following statements are facts, an elementary school course of eight grades seèms not altogether wise. Approximately 16 per cent of all pupils repeat one or more grades (see page 97 in "Laggards in Our Schools). The average number of years which the average pupil in thirty-one American cities spends for completing eight grades is about 9.64 (see page 87 in "Laggards in Our Schools"). Would it not be better to divide the elementary school course into nine or even ten grades, so that the "slow but sure" might progress regularly, and then provide more rapid progress for those who now complete the course in nine, eight, seven, or six years? * You will note that the last sentence is a question. I do not presume to defend this plan, only to present it for your consideration. Whatever light you can give me will be gratefully received. Wells A. Hall, Superintendent of Schools. Concord, Mass. ,^..4.^.
Cilt: 72
Sayı: 22 (1808)
Sayfa: p. 612
Yayın Tarihi: 1910-12-15
ISSN: 0022-0574
13
The Influence of Iron Oxide on Wear of Rubbing Surfaces
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Science
Yayıncı:
American Association for the Advancement of Science
Yazar(lar) :
Wells A. Webb
Konu :
Biological Sciences, Science and Mathematics, General Science
Yıl :
1944
Wells A. Webb
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 99
Sayı: 2575
Sayfa: pp. 369-371
Yayın Tarihi: 1944-05-05
ISSN: 0036-8075
Sınıflandırma :
14
Standardizing Production-What Has Been Done and What Can Be Done
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
The Annals of the American Academy of Political and Social Science
Yayıncı:
Sage Publications, Inc.
Yazar(lar) :
Wells A. Sherman
Konu :
Economics, Social Sciences, Sociology, Business & Economics, Political Science
Yıl :
1929
Wells A. Sherman
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 142
Sayfa: pp. 419-424
Yayın Tarihi: 1929-03-01
ISSN: 0002-7162
15
The Arabidopsis AtAAE13.1 Gene Enhances Salt Stress Tolerance in Angiosperms and Gymnosperm Plant Cells
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
In Vitro Cellular & Developmental Biology - Plant
Yazar(lar) :
Mingqin Zhou , Wells A. Thompson , Wei Tang
Konu :
Plant Science, Biotechnology
Yıl :
2020
Wells A. Thompson
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The Arabidopsis malonyl-CoA synthetase gene AAE13.1 (AtAAE13.1) plays important roles in cell metabolism, plant growth and development, and environmental stress responses. However, function of AtAAE13.1 in NaCl stress tolerance is not determined yet. Cell suspension cultures of different plant species including rice (Oryza sativa L.), cotton (Gossypium hirsutum L.), and white pine (Pinus strobus L.) were transformed using Agrobacterium tumefaciens strain GV3101 harboring pBI-AtAAE13.1. After confirmation of integration of the AtAAE13.1 gene into the genome by polymerase chain reaction (PCR), Southern and northern blot analyses, NaCl stress tolerance was examined in AtAAE13.1 transgenic cells of O. sativa, G. hirsutum, and P. strobus. AtAAE13.1 expression enhanced NaCl stress tolerance by increasing cell viability and growth rate, decreasing lipid peroxidation, increasing the oxidation rate, and elevating the content of amino acids, glycolate, and phosphoglycolate, as well as elevating the amount of sucrose, glucose, and fructose. In rice cells, AtAAE13.1 elevated expression of the Ca2+-dependent protein kinase (CPK) genes under NaCl stress. Overexpression of the AtAAE13.1 gene may be useful for engineering NaCl stress tolerance in different plant species.
DOI : 10.1007/s11627-020-10083-y
Anahtar Kelimeler : AtAAE13.1 gene, Cell suspension cultures, Cotton, NaCl stress, Rice, White pine
ISSN: 1054-5476 1475-2689
Sayı: 6
Cilt: 56
Sayfa: 750-764
Sınıflandırma :
16
Microbial Populations of the Colorado Alpine Tundra
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Arctic and Alpine Research
Yayıncı:
INSTAAR, University of Colorado
Yazar(lar) :
Wells A. Shulls
Konu :
Geography, Biological Sciences, Ecology & Evolutionary Biology, Science and Mathematics, Social Sciences
Yıl :
1976
Wells A. Shulls
Yayıncı Web Sitesi
Kaydet Alıntıla
A preliminary study in the alpine of the Niwot Ridge, Front Range, Colorado, shows that all the bacteria present are mesophiles. The majority of the bacteria found were rods, Bacillus and Bacterium, which produce gums and other extracellular products. There are pigmented cocci present. No anaerobic bacteria or thermophiles were found. The bacterial counts show an unexpected change with the seasons of the year, the lowest number occurring in the autumn and rising through the winter to a maximum in the summer.
Cilt: 8
Sayı: 4
Sayfa: pp. 387-391
Yayın Tarihi: 1976-11-01
ISSN: 0004-0851
17
BACKGROUND AND MODERN DEVELOPMENTS IN WATER LAW IN THE UNITED STATES
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Natural Resources Journal
Yayıncı:
Regents of the University of New Mexico on behalf of its School of Law
Yazar(lar) :
WELLS A. HUTCHINS
Konu :
Environmental Studies, Law, Social Sciences
Yıl :
1962
WELLS A. HUTCHINS
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 2
Sayı: 3
Sayfa: pp. 416-444
Yayın Tarihi: 1962-12-01
ISSN: 0028-0739
18
Management Strategies for Patients with KRAS Mutations
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Current Colorectal Cancer Reports
Yazar(lar) :
Stephen Leong , S. Gail Eckhardt , Wells A. Messersmith
Konu :
Gastroenterology, Oncology, Hepatology
Yıl :
2010
Wells A. Messersmith
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
In an era of targeted therapies and personalized medicine, the search for predictive and prognostic biomarkers has reached the forefront in cancer research. Testing for KRAS mutation status in the treatment of colorectal cancer (CRC) has now become standard of care, especially for patients being considered for treatment with antibodies to the epidermal growth factor receptor (EGFR). Because metastatic CRC patients whose tumors harbor KRAS mutations do not respond to EGFR-targeting antibodies, their management is challenging. As our understanding of the role of KRAS mutations grows, new treatment strategies are being devised but are not yet ready for clinical use. In this review, we examine some of these potential strategies.
DOI : 10.1007/s11888-010-0066-x
Anahtar Kelimeler : KRAS, KRAS mutations, Colorectal cancer, Novel therapeutics
ISSN: 1556-3790 1556-3804
Sayı: 4
Cilt: 6
Sayfa: 199-205
19
Antibody drug conjugates under investigation in phase I and phase II clinical trials for gastrointestinal cancer.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Expert Opin Investig Drugs
Yazar(lar) :
Alexis D Leal , Anuradha Krishnamurthy , Lia Head , Wells A Messersmith
Yıl :
2018
Wells A Messersmith
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Antibody drug conjugates (ADCs) represent a developing class of anticancer therapeutics which are designed to selectively deliver a cytotoxic payload to tumors, while limiting systemic toxicity to healthy tissues. There are several ADCs which are currently in various stages of clinical development for the treatment of gastrointestinal malignancies. Areas covered: We discuss the biologic rationale and review the clinical experience with ADCs in the treatment of gastrointestinal malignancies, summarizing the pre-clinical and phase I/II clinical trial data that have been completed or are ongoing. Expert opinion: While there have been significant advances in the development of ADCs since they were first introduced, several challenges remain. These challenges include (i) the selection of an ideal antigen target which is tumor specific and internalized upon binding, (ii) selection of an antibody which has high affinity for its antigen target and low immunogenicity, (iii) selection of a potent payload which is cytotoxic at sub-nanomolar concentrations, and (iv) optimal design of a linker to confer ADC stability with limited off-site toxicity. Efforts are ongoing to address these issues and innovate the ADC technology to improve the safety and efficacy of these agents.
DOI : 10.1080/13543784.2018.1541085
Anahtar Kelimeler : Adenocarcinoma, antibody drug conjugate, cholangiocarcinoma, colorectal cancer, drug conjugates, esophageal cancer, gastric cancer, gastrointestinal malignancies, immunoconjugates, pancreatic cancer
Sınıflandırma :
20
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate ABT-751, ABT-751 glucuronide, and ABT-751 sulfate in human plasma for clinical pharmacology studies
Dergi Makalesi

Dergi Makalesi
Kaynak :
Science Direct
Dergi:
Journal of Pharmaceutical and Biomedical Analysis
Yayıncı:
Elsevier
Yazar(lar) :
Michelle A. Rudek , Ming Zhao , Ping He , Wells A. Messersmith , Sharyn D. Baker
Yıl :
2006
Wells A. Messersmith
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
A method has been developed for the quantitation of ABT-751, ABT-751 glucuronide, and ABT-751 sulfate in human plasma. ABT-751 and metabolites were separated from endogenous material on a C18 column with acetonitrile–ammonium acetate (2 mM) mobile phase containing formic acid (0.1%, v/v) using isocratic flow for 5 min. The analytes were monitored by tandem-mass spectrometry. Calibration curves were generated over the range of 20–5000 ng/ml for ABT-751, ABT-751 glucuronide, and ABT-751 sulfate. A 20,000 ng/ml sample that was diluted 1:10 (v/v) with plasma was accurately quantitated. The method has been successfully applied to study the plasma pharmacokinetics of ABT-751 in humans.
DOI : 10.1016/j.jpba.2006.04.010
Anahtar Kelimeler : ABT-751, LC/MS/MS, Pharmacokinetics
ISSN: 0731-7085
Sayı: 2
Cilt: 42
Sayfa: 253-260
Sınıflandırma :
21
Unusual Tumors of the Colon, Rectum, and Anus
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Textbook of Uncommon Cancer
Yayıncı:
John Wiley & Sons, Ltd
Yazar(lar) :
Diane Reidy-Lagunes , Christopher H. Lieu , Wells A. Messersmith , Karyn Goodman
Yıl :
2017
Wells A. Messersmith
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Cancers of the colon, rectum, and anus account for more than 150,000 new cases in the USA each year. The overwhelming majority (approximately 97%) of these are adenocarcinomas of the colon or rectum. Of the 3% that make up the uncommon tumors, approximately half, or 1.5% of the total, will be anal carcinomas (squamous and cloacogenic) and one‐third (approximately 1% of the total) will be carcinoid or neuroendocrine tumors. The remaining rare tumors, together comprising about 1% of all large bowel tumors, will be primary intestinal lymphomas, sarcomas, and melanomas. Treatment and prognoses of these tumors vary greatly and will be discussed in this chapter.
DOI : 10.1002/9781119196235.ch31
ISBN:9781119196204
Sayfa: 458-469
22
Comparative Study of Metabolic Activities of Bacteria in Three Ecoregions of the Colorado Front Range, U.S.A.
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Arctic and Alpine Research
Yayıncı:
INSTAAR, University of Colorado
Yazar(lar) :
Wells A. Shulls , Rocco L. Mancinelli
Konu :
Geography, Biological Sciences, Ecology & Evolutionary Biology, Science and Mathematics, Social Sciences
Yıl :
1982
Wells A. Shulls
Yayıncı Web Sitesi
Kaydet Alıntıla
A comparative study of the bacteria occurring in soils of montane grasslands, montane forests, subalpine forests, and alpine tundra habitats was conducted to ascertain the types of bacterial metabolic or enzymatic activities in the soils of these ecosystems. Elevation substantially affected taxa isolated. Amylolytic, cellulolytic, and pectinolytic activity was observed in cultured isolates from all areas. Proteolytic activity was not observed in isolates from alpine tundra but was observed in cultures isolated from all other areas. Microbial population sizes remained constant with increased elevation, but organismic diversity decreased. Nitrifying and denitrifying bacteria were isolated from all ecosystems studied. Free-living nitrogen-fixing organisms were isolated in large numbers from all areas except the alpine tundra. Rapid degradation of cellulose seems to be the result of a cooperative effect between bacteria and fungi in alpine tundra soils.
Cilt: 14
Sayı: 1
Sayfa: pp. 53-57
Yayın Tarihi: 1982-02-01
ISSN: 0004-0851
23
Basic Water Rights Doctrines and Their Implications for River Basin Development
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Law and Contemporary Problems
Yayıncı:
Duke University School of Law
Yazar(lar) :
Wells A. Hutchins , Harry A. Steele
Konu :
Law
Yıl :
1957
Wells A. Hutchins
Yayıncı Web Sitesi
Kaydet Alıntıla
Cilt: 22
Sayı: 2
Sayfa: pp. 276-300
Yayın Tarihi: 1957-04-01
ISSN: 0023-9186
Sınıflandırma :
24
Patient-derived tumour xenografts as models for oncology drug development
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature Reviews Clinical Oncology
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
John J. Tentler , Aik Choon Tan , Colin D. Weekes , Antonio Jimeno , Stephen Leong , Todd M. Pitts , John J. Arcaroli , Wells A. Messersmith , S. Gail EckhardtJohn J. Tentler , Aik Choon Tan , Colin D. Weekes , Antonio Jimeno , Stephen Leong , Todd M. Pitts , John J. Arcaroli , Wells A. Messersmith , S. Gail Eckhardt
Yıl :
2012
Wells A. Messersmith Wells A. Messersmith
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DOI : 10.1038/nrclinonc.2012.61
ISSN: 1759-4774
Sayı: 6
Cilt: 9
Sayfa: 338-350
25
Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Oncogene
Yayıncı:
Springer Science and Business Media LLC
Yazar(lar) :
Hector Esquer , Qiong Zhou , Travis Nemkov , Adedoyin D. Abraham , Sébastien Rinaldetti , Yu-Chi Chen , Xiaohu Zhang , Michael V. Orman , Angelo Du2019Alessandro , Marc Ferrer , Wells A. Messersmith , Daniel V. LaBarberaHector Esquer , Qiong Zhou , Travis Nemkov , Adedoyin D. Abraham , Sébastien Rinaldetti , Yu-Chi Chen , Xiaohu Zhang , Michael V. Orman , Angelo Du2019Alessandro , Marc Ferrer , Wells A. Messersmith , Daniel V. LaBarbera
Yıl :
2021
Wells A. Messersmith Wells A. Messersmith
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DOI : 10.1038/s41388-021-01728-2
ISSN: 0950-9232
Sayı: 16
Cilt: 40
Sayfa: 2884-2897
Sınıflandırma :
26
An Improved High Yield Total Synthesis and Cytotoxicity Study of the Marine Alkaloid Neoamphimedine: An ATP-Competitive Inhibitor of Topoisomerase IIα and Potent Anticancer Agent
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Marine Drugs
Yazar(lar) :
Linfeng Li , Adedoyin D. Abraham , Qiong Zhou , Hadi Ali , Jeremy V. O'Brien , Brayden D. Hamill , John J. Arcaroli , Wells A. Messersmith , Daniel V. LaBarbera
Yıl :
2014
Wells A. Messersmith
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 Piri Tam Metin Bulucu
Kaydet Alıntıla
Recently, we characterized neoamphimedine (neo) as an ATP-competitive inhibitor of the ATPase domain of human Topoisomerase IIα. Thus far, neo is the only pyridoacridine with this mechanism of action. One limiting factor in the development of neo as a therapeutic agent has been access to sufficient amounts of material for biological testing. Although there are two reported syntheses of neo, both require 12 steps with low overall yields (≤6%). In this article, we report an improved total synthesis of neo achieved in 10 steps with a 25% overall yield. In addition, we report an expanded cytotoxicity study using a panel of human cancer cell lines, including: breast, colorectal, lung, and leukemia. Neo displays potent cytotoxicity (nM IC50 values) in all, with significant potency against colorectal cancer (lowest IC50 = 6 nM). We show that neo is cytotoxic not cytostatic, and that neo exerts cytotoxicity by inducing G2-M cell cycle arrest and apoptosis.
DOI : 10.3390/md12094833
Anahtar Kelimeler : marine natural product, pyridoacridine, neoamphimedine, total synthesis, topoisomerase II, cytotoxicity, colorectal cancer, cancer therapeutics
ISSN: 1660-3397
Cilt: 12
Sayı: 9
Sayfa: 4833 - 4850
Sınıflandırma :
27
A Phase I Dose-Escalation Study of Linsitinib (OSI-906), a Small-Molecule Dual Insulin-Like Growth Factor-1 Receptor/Insulin Receptor Kinase Inhibitor, in Combination with Irinotecan in Patients with Advanced Cancer.
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
PubMed
Dergi:
Oncologist
Yazar(lar) :
S Lindsey Davis , S Gail Eckhardt , Jennifer R Diamond , Wells A Messersmith , Arvind Dasari , Colin D Weekes , Christopher H Lieu , Madeline Kane , Aik Choon Tan , Todd M Pitts , Stephen Leong
Yıl :
2018
Wells A Messersmith
Yayıncı Web Sitesi
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Kaydet Alıntıla
The maximum tolerated dose of the combination of linsitinib and irinotecan is linsitinib 450 mg daily on days 1-3 every 7 days and irinotecan 125 mg/m2 days 1 and 8 of a 21-day cycle.The adverse effects associated with the combination are not significantly increased beyond what is expected of each drug as a single agent.Multiple negative trials of insulin-like growth factor-1 receptor inhibitors performed in unselected patient populations led to the early discontinuation of linistinib development and this trial.Earlier integration of assessment of potential predictive biomarkers into clinical trials, as was planned in this study, is vital to the development of targeted therapies in oncology.
DOI : 10.1634/theoncologist.2018-0315
Sınıflandırma :
28
Targeting the WNT Signaling Pathway in Cancer Therapeutics
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Dergi Makalesi
Kaynak :
Wiley Online Library
Dergi:
The Oncologist
Yazar(lar) :
David Tai , Keith Wells , John Arcaroli , Chad Vanderbilt , Dara L. Aisner , Wells A. Messersmith , Christopher H. Lieu
Konu :
Cancer Research, Oncology
Yıl :
2015
Wells A. Messersmith
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DOI : 10.1634/theoncologist.2015-0057
ISSN: 1083-7159
Sayı: 10
Cilt: 20
Sayfa: 1189-1198

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