Piri Keşif Aracı

Ek Bilgiler

Anahtar Kelimeler : self-intersection, rigid origami, quaternion, mechanism

Sınıflandırma :

Fizik %41

Nano Ölçekli Bilim ve Teknoloji %100

Matematik %39

Beşeri ve Sosyal Bilimlerde Matematik %71

Çevre Biliminde Matematiksel Uygulamalar %29

2

A solution for folding rigid tall shopping bags

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , You Z

Yıl :

2011

Wu W

Ek Bilgiler

Anahtar Kelimeler : self-intersection, rigid origami, quaternion, mechanism

Sınıflandırma :

Mimarlık %94

Mimarlık %100

3

Image formation in diffusion MRI: A review of recent technical developments

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Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , Miller KL

Yıl :

2017

Wu W

Özet Ek Bilgiler

Diffusion magnetic resonance imaging (MRI) is a standard imaging tool in clinical neurology, and is becoming increasingly important for neuroscience studies due to its ability to depict complex neuroanatomy (eg, white matter connectivity). Single-shot echo-planar imaging is currently the predominant formation method for diffusion MRI, but suffers from blurring, distortion, and low spatial resolution. A number of methods have been proposed to address these limitations and improve diffusion MRI acquisition. Here, the recent technical developments for image formation in diffusion MRI are reviewed. We discuss three areas of advance in diffusion MRI: improving image fidelity, accelerating acquisition, and increasing the signal-to-noise ratio. LEVEL OF EVIDENCE: 5 J. Magn. Reson. Imaging 2017.

Anahtar Kelimeler : accelerated imaging, image artifacts, diffusion mri, pulse sequence, navigation, high-resolution imaging

Sınıflandırma :

Biyotıp %32

Görüntüleme ve Radyoloji %100

Bilgisayar Bilimi %26

Görüntü İşleme ve Bilgisayarla Görme %100

Tıp ve Halk Sağlığı %20

Nöroradyoloji %98

4

Miura-base rigid origami: parameterizations of first-level derivative and piecewise geometries

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Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Gattas JM , Wu W , You Z

Yıl :

2013

Wu W

Özet Ek Bilgiler

Miura and Miura-derivative rigid origami patterns are increasingly used for engineering and architectural applications. However, geometric modelling approaches used in existing studies are generally haphazard, with pattern identifications and parameterizations varying widely. Consequently, relationships between Miura-derivative patterns are poorly understood, and widespread application of rigid patterns to the design of folded plate structures is hindered. This paper explores the relationship between the Miura pattern, selected because it is a commonly used rigid origami pattern, and first-level derivative patterns, generated by altering a single characteristic of the Miura pattern. Five alterable characteristics are identified in this paper: crease orientation, crease alignment, developability, flat-foldability, and rectilinearity. A consistent parameterization is presented for five derivative patterns created by modifying each characteristic, with physical prototypes constructed for geometry validation. It is also shown how the consistent parameterization allows first-level derivative geometries to be combined into complex piecewise geometries. All parameterizations presented in this paper have been compiled into a matlab Toolbox freely available for research purposes.

Anahtar Kelimeler : parameterization, sbtmr, rigid origami, folded plate structures, miura

Sınıflandırma :

Mühendislik %68

Robotik ve Otomasyon %79

5

Reducing slab boundary artifacts in three-dimensional multislab diffusion MRI using nonlinear inversion for slab profile encoding (NPEN)

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Kaynak 1:

Ora Articles

Kaynak 2:

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , Koopmans P , Frost R , Miller K

Yıl :

2014

Wu W

Yayıncı Web Siteleri

Özet Ek Bilgiler

To propose a method to reduce the slab boundary artifacts in three-dimensional multislab diffusion MRI.Bloch simulation is used to investigate the effects of multiple factors on slab boundary artifacts, including characterization of residual errors on diffusion quantification. A nonlinear inversion method is proposed to simultaneously estimate the slab profile and the underlying (corrected) image.Correction results of numerical phantom and in vivo data demonstrate that the method can effectively remove slab boundary artifacts for diffusion data. Notably, the nonlinear inversion is also successful at short TR, a regimen where previously proposed methods (slab profile encoding and weighted average) retain residual artifacts in both diffusion-weighted images and diffusion metrics (mean diffusion coefficient and fractional anisotropy).The nonlinear inversion for removing slab boundary artifacts provides improvements over existing methods, particularly at the short TRs required to maximize SNR efficiency. Magn Reson Med, 2015. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Kaynak 1: https://ora.ox.ac.uk/objects/uuid:6a7f6ef5-f20b-4c25-afd9-c2b7d9c4c03d arayıcılığı görüntüle.
Kaynak 2: https://ora.ox.ac.uk/objects/uuid:ba56fe31-b9e2-42e4-87fb-6a7b3131ab1b arayıcılığı görüntüle.

Anahtar Kelimeler : boundary artifacts, 3d diffusion mri, multi-slab, nonlinear inversion, sbtmr

Sınıflandırma :

Fizik %64

Mühendislik Matematiği %92

6

Diffusion Acceleration with Gaussian process Estimated Reconstruction (DAGER)

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Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , Koopmans PJ , Andersson JLR , Miller KL

Yıl :

2019

Wu W

Özet Ek Bilgiler

Purpose: Image acceleration provides multiple benefits to diffusion MRI, with in‐plane acceleration reducing distortion and slice‐wise acceleration increasing the number of directions that can be acquired in a given scan time. However, as acceleration factors increase, the reconstruction p... Expand abstract

Sınıflandırma :

Bilgisayar Bilimi %42

Görüntü İşleme ve Bilgisayarla Görme %63

İstatistik %29

Bilgisayar Bilimlerinde Olasılık ve İstatistik %42

İstatistik ve Hesaplama %32

7

Magnetothermoelectric effects in (TMTSF)2 Cl O4

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Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Nam M-S , Ardavan A , Wu W , Chaikin PM

Yıl :

2006

Wu W

Özet Ek Bilgiler

We have measured the thermopower and Nernst effects in the quasi-one-dimensional organic molecular metal (TMTSF)2 Cl O4 as a function of temperature and magnetic field strength and orientation. At 10 K this material exhibits a maximum Nernst coefficient of 12 μVKT, one of the largest ever observed in a metal. The thermoelectric effects are very sensitive to the reconstruction of the band structure caused by the Cl O4 anion ordering. © 2006 The American Physical Society.

Sınıflandırma :

Fizik %58

Süperiletkenlik %100

Malzeme Bilimi %33

Moleküler Yapı ve Spektrumlar %57

Katı Hal Fiziği %24

8

Magnetothermoelectric effects in (TMTSF)(2)CIO4

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Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Nam M-S , Ardavan A , Wu W , Chaikin PM

Yıl :

2006

Wu W

Ek Bilgiler

Sınıflandırma :

Fizik %34

Süperiletkenlik %100

9

An efficient microalgal biomass harvesting method with a high concentration ratio using the polymer-surfactant aggregates process

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Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , Shen LC , Hu HY , Hankins NP , Huang W

Yıl :

2018

Wu W

Özet Ek Bilgiler

The high cost and energy consumption related to the downstream harvesting and dewatering process is one of the most important bottlenecks limiting the commercial production of microalgal bioenergy. In this study, a novel microalgal biomass harvesting technique has been developed using polymer surfactant aggregates (PSAs). This approach has been applied to three different microalgal strains and two cynobacterial strains with a recovery efficiency of over 80%. In particular, the recovery efficiency of Chlorella sp. ZTY4 with a biomass concentration of 1.43 g·L-1 can be as high as 99.9% using 360 mg·L-1 poly (acrylic acid) (PAA) and 4 mM (1432 mg·L-1) cetylpyridinium chloride (CPC). In addition, with this PAA and CPC dosage, the recovery efficiency of Chlorella sp. ZTY4 remains above 90% for biomass concentrations up to 2.5 g·L-1. Furthermore, the water content in the harvested biomass is below 70% with a corresponding concentration ratio of 231. The total flocculation time needed for this technique is 20 minutes. The optimum dosage ratio for PAA to CPC ranges from 90 to 100 mg/mmol. Based on these results, an efficient harvesting method with a high concentration ratio is proposed to simplify the whole downstream harvesting and dewatering processes of microalgal biomass.

Anahtar Kelimeler : harvesting, microalgal bioenergy, polymer-surfactant aggregates, flocculation

Sınıflandırma :

Kimya %89

Biyorganik Kimya %61

Biyomedikal Mühendisliği ve Biyoteknoloji %19

10

A machine learning approach to diffusion MRI partial volume estimation

Konferans Bildirileri

Kaynak :

Ora Articles

Yazar(lar) :

Vallee E , Wu W , Galassi F , Jbabdi S , Smith S

Yıl :

2018

Wu W

Özet Ek Bilgiler

Tissue-type partial volume modelling is generally an ill-posed problem in single-shell diffusion MRI. On the other hand, T1w images are typically acquired along with the diffusion data, and allow for an accurate estimation of the tissue partial volume fractions (PVFs). We propose in this paper to compare different data driven approach to predict the T1w-derived PVFs from the diffusion data. The aim is to alleviate the within subject mis-registration between the two modalities. Our experiments show that the random forests is the most accurate and scalable method for predicting the tissue partial volume fractions. Additionally, such predictions can be used to inform the fitting of the two-compartment model to retrieve a diffusion tensor that is not biased by partial volume effects or constraints.

DOI : 10.1007/978-3-030-00536-8_5

Sınıflandırma :

İstatistik %41

İstatistik ve Hesaplama %22

Biyoistatistik %20

Bilgisayar Bilimi %40

Görüntü İşleme ve Bilgisayarla Görme %95

11

Mineral binding affinities of bisphosphonates.

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Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Nancollas GH , Mangood AH , Gaafar EM , Wu W , Ebetino FH , Phipps RJ , Russell RGG

Yıl :

2002

Wu W

Ek Bilgiler

Sınıflandırma :

Tıp ve Halk Sağlığı %41

Ağız ve Çene Cerrahisi %100

Kimya %22

Analitik Kimya %100

12

Diastereodivergent organocatalytic asymmetric vinylogous Michael reactions

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Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Li X , Lu M , Dong Y , Wu W , Qian Q , Ye J , Dixon DJ

Yıl :

2014

Wu W

Özet Ek Bilgiler

One of the major challenges of modern asymmetric catalysis is the ability to selectively control the formation of all diastereoisomers of reaction products possessing multiple stereocenters. Pioneers of such diastereodivergent catalytic asymmetric processes have focused on reactions where the newly formed stereogenic centres are proximal to the active carbonyl group. To date, however, diastereodivergent reactions at remote positions remain an unmet challenge. Herein, we describe a catalyst-controlled diastereodivergence in the formation of remote stereocenters in the direct vinylogous Michael reactions of β, γ-unsaturated butenolides to α, β-unsaturated ketones. The reactions are enabled by two complementary, non-enantiomeric multifunctional catalysts, which mutually activate and organise both reactants, affording either the syn- or anti-adduct with high diastereo- and enantioselectivity. These two catalytic systems are also applicable in the Mukaiyama–Michael reactions and tandem Michael–Michael reactions.

Sınıflandırma :

Kimya %100

Organometalik Kimya %94

13

Selective sensor fusion for neural visual-inertial odometry

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Kaynak :

Ora Articles

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ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Chen C , Rosa S , Miao Y , Lu CX , Wu W , Markham A , Trigoni N

Yıl :

2019

Wu W

Özet Ek Bilgiler

Deep learning approaches for Visual-Inertial Odometry (VIO) have proven successful, but they rarely focus on incorporating robust fusion strategies for dealing with imperfect input sensory data. We propose a novel end-to-end selective sensor fusion framework for monocular VIO, which fuses monocular images and inertial measurements in order to estimate the trajectory whilst improving robustness to real-life issues, such as missing and corrupted data or bad sensor synchronization. In particular, we propose two fusion modalities based on different masking strategies: deterministic soft fusion and stochastic hard fusion, and we compare with previously proposed direct fusion baselines. During testing, the network is able to selectively process the features of the available sensor modalities and produce a trajectory at scale. We present a thorough investigation on the performances on three public autonomous driving, Micro Aerial Vehicle (MAV) and hand-held VIO datasets. The results demonstrate the effectiveness of the fusion strategies, which offer better performances compared to direct fusion, particularly in presence of corrupted data. In addition, we study the interpretability of the fusion networks by visualising the masking layers in different scenarios and with varying data corruption, revealing interesting correlations between the fusion networks and imperfect sensory input data.

Sınıflandırma :

Bilgisayar Bilimi %100

Görüntü İşleme ve Bilgisayarla Görme %74

14

Comparative mineral binding affinities of selected bisphosphonates

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Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Nancollas GH , Mangood AH , Gaafar EM , Wu W , Ebetino FH , White DJ , Phipps RJ , Russell RGG

Yıl :

2002

Wu W

Ek Bilgiler

Sınıflandırma :

Yaşam Bilimleri %40

Kimya %30

15

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the european scleroderma trials and research (eustar) cohort

Dergi Makalesi

Kaynak :

DSpace Makaleler

Dergi:

Annals of the Rheumatic Diseases

Yayıncı:

BMJ Publishing Group

Yazar(lar) :

Wu W. , Jordan S. , Graf N. , de Oliveira Pena J. , Curram J. , Allanore Y. , Sarzi Puttini P.

Konu :

All-cause death, Diffuse cutaneous systemic sclerosis, Lung function decline, Progressive skin fibrosis, Visceral organ progression

Yıl :

2019

Wu W.

Özet Ek Bilgiler

Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). Methods We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ?7, valid mRSS at 12±3 months after baseline and ?1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ?25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. Associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. Results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. Survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ?10% (53.6% vs 34.4%; p<0.001) and all-cause death (15.4% vs 7.3%; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRSS (?22/51) or short disease duration (?15 months). In multivariable analyses, skin progression within 1 year was independently associated with FVC decline ?10% (HR 1.79, 95% CI 1.20 to 2.65) and all-cause death (HR 2.58, 95% CI 1.31 to 5.09). Conclusions Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcSSc during follow-up. These results confirm mRSS as a surrogate marker in dcSSc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Anahtar Kelimeler : All-cause death, Diffuse cutaneous systemic sclerosis, Lung function decline, Progressive skin fibrosis, Visceral organ progression, article

Cilt: 78
Sayı: 5
ISSN: 0003-4967

16

Bronchodilator reversibility in patients with COPD revisited: short-term reproducibility

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of COPD

Yazar(lar) :

Pascoe S , Wu W , Zhu CQ , Singh D

Yıl :

2016

Wu W

Özet Ek Bilgiler

Steven Pascoe,1 Wei Wu,2 Chang-Qing Zhu,3 Dave Singh4 1GSK, Respiratory Medicines Development Center, 2PAREXEL International, Research Triangle Park, NC, USA; 3GSK, Clinical Statistics (Respiratory), Middlesex, UK; 4Medicines Evaluation Unit, University Hospital of South Manchester NHS Foundation Trust, University of Manchester, Manchester, UK Abstract: Categorization of patients with COPD as reversible or nonreversible to a bronchodilator may change over time. This post hoc analysis aimed to determine if an individual’s reversibility, when treated as a continuous variable, could predict his/her future response to two short-acting bronchodilators: albuterol and ipratropium. The analysis was completed using data from a 4-week, randomized, open-label, two-period crossover study (NCT01691482; GSK study DB2114956). Patients received albuterol (doses: UK =4×100 µg/puff; US =4×90 µg/puff) followed 1 hour later by ipratropium (4×20 µg/puff) or vice versa during treatment Period 1. The order of treatments was reversed during Period 2. Predefined efficacy end points included pre- and post-bronchodilator forced expiratory volume in 1 second. The correlation coefficient between bronchodilator response on Days 1 and 10 was investigated, as well as the correlation between treatment response on Day 1 and the mean treatment response on Days 5–10, for each individual patient. Bronchodilator response to albuterol on Day 1 was strongly correlated with that on Day 10 (r=0.64; n=53). The correlation coefficient of bronchodilator treatment response on Day 1 and Days 5–10 was 0.78 (P<0.001; n=53) and 0.76 (P<0.001; n=54) for albuterol and ipratropium, respectively. A single measurement of the initial bronchodilator response to albuterol or ipratropium was, therefore, highly correlated with the subsequent mean bronchodilator response over 5–10 days, demonstrating its potential usefulness for future treatment decisions. Keywords: bronchodilator responsiveness, FEV1, correlation, short-acting bronchodilators, spirometry

Anahtar Kelimeler : bronchodilator responsiveness, reversibility, short-acting bronchodilators, spirometry

Cilt: 11
Sayfa: 2035 - 2040

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Pnömoloji ve Solunum Sistemi %84

17

Comparison of prognostic values of high-sensitivity cardiac troponin T and N-terminal prohormone brain natriuretic peptide to assess mortality in elderly inpatients

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Clinical Interventions in Aging

Yazar(lar) :

Chen JR , Wang Q , Wu W , Zhang SJ

Yıl :

2018

Wu W

Özet Ek Bilgiler

Jie-Ruo Chen,1 Qing Wang,1 Wei Wu,2 Shao-Jing Zhang1 1Department of Geriatrics, Fuxing Hospital, affiliated to Capital Medical University, Beijing, China; 2General Practice Ward, Fuxing Hospital, affiliated to Capital Medical University, Beijing, China Background: Studies have shown that increases in low-level high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) in the elderly population lead to high risk of adverse clinical outcomes, such as mortality. In this study, associations between the two biomarkers and long-term mortality in elderly patients hospitalized for medical conditions other than acute cardiovascular events were investigated. A comparison of the predictive value of hs-cTnT and NT-proBNP for all-cause mortality was conducted. Methods: A cohort of 715 elderly inpatients free of acute cardiovascular events was initially recruited. Based on tertiles of baseline hs-cTnT and NT-proBNP levels, the elderly were arranged into low, middle, and high groups. The mortality of each group was observed and the predictive values of hs-cTnT and NT-proBNP compared. Additionally, all-cause mortality was analyzed for hs-cTnT and NT-proBNP combined. Results: There were 135 (18.9%) all-cause mortality cases identified during follow-up (median 47 months). The upper tertile of hs-cTnT was significantly associated with an increased risk of mortality (HR 3.29, 95% CI 1.85–5.85), even after adjustment for potential confounders. However, there were no significant differences observed in mortality rates among the three NT-proBNP groups after adjustment for potential confounders (HR 1.77, 95% CI 0.83–3.17). Compared to NT-proBNP, hs-cTnT was a better predictor of mortality, as area under curves for hs-cTnT and NT-proBNP at 60 months were 0.712 (95% CI 0.616–0.809) and 0.585 (95% CI 0.483–0.6871), respectively. Also, the combination of the two cardiac biomarkers did not render a better predictive value for mortality than hs-cTnT alone. Conclusion: Unlike hs-cTnT, baseline NT-proBNP levels failed to show an independent association with all-cause mortality in hospitalized elderly without acute cardiovascular events. hs-cTnT provided significant prognostic value for mortality in the study cohort. Keywords: high-sensitivity cardiac troponin T (hs-cTnT), N-terminal prohormone brain natriuretic peptide (NT-proBNP), nonacute cardiovascular events, elderly patients

Anahtar Kelimeler : High-sensitivity cardiac troponin T (hs-TnT), N-terminal proB-type natriuretic peptide (NT-proBNP), Non-acute cardiovascular events, In-hospital elderly patients

Cilt: 14
Sayfa: 81 - 90

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Kardiyoloji %87

18

Evaluation of the clinical effect of small-volume resuscitation on uncontrolled hemorrhagic shock in emergency

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Therapeutics and Clinical Risk Management

Yazar(lar) :

Zhao G , Wu W , Feng QM , Sun J

Yıl :

2017

Wu W

Özet Ek Bilgiler

Gang Zhao, Wei Wu, Qi-ming Feng, Jian Sun Department of Emergency, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of China Objective: The objective of the present study was to explore the resuscitative effect of small-volume resuscitation on uncontrolled hemorrhagic shock in emergency. Methods: In this study, the resuscitative effects in 200 trauma patients with uncontrolled hemorrhagic shock in emergency were studied. Half of these patients were infused with hypertonic/hyperoncotic fluid (small-volume resuscitation group, n=100), whereas the rest were infused with Hespan and lactated Ringer’s solution (conventional fluid resuscitation group, n=100). The changes in hemodynamics, coagulation function, blood biochemistry, blood hematology, and the average infusion volume in both the groups were comparatively studied. Results: It was found that the hemodynamics were improved in both the groups after resuscitation. Interestingly, compared with trauma patients infused with Hespan and lactated Ringer’s solution, the growth rate, range, and time duration of the mean arterial pressure of the patients in small-volume resuscitation group increased significantly, and the shock index decreased progressively; in the 60th min after the resuscitation, blood index including hemoglobin, hematocrit, red blood cells, white blood cells, and platelet declined, whereas prothrombin time and activated partial thromboplastin time were prolonged in both the groups, but these changes were less obvious in the small-volume group. In addition, the average infusion volume of patients in the small-volume group was less than that of patients in conventional fluid resuscitation group.Conclusion: Featured with small infusion volume and less influence to coagulation function and homeostasis of human body, small-volume resuscitation possesses a significantly higher resuscitative effect. Therefore, trauma patients may have a better chance to maintain the hemodynamic stability and the survival rate, or recovery speed will be increased when traditional aggressive fluid resuscitation is replaced by small-volume resuscitation. Keywords: small-volume resuscitation, shock, hemorrhage, emergency

Anahtar Kelimeler : Small volume resuscitation, shock, hemorrhage, emergency

Cilt: 13
Sayfa: 387 - 392

Sınıflandırma :

Tıp ve Halk Sağlığı %98

Yoğun ve Yoğun Bakım Tıbbı %48

19

The clinical significance of γ-catenin in acute myeloid leukemia

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Xu J , Wu W , Shen W , Liu P

Yıl :

2016

Wu W

Özet Ek Bilgiler

Jiadai Xu,1 Wei Wu,1 Wenyi Shen,1 Peng Liu2 1Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 2Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China Abstract: Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in the pathogenesis of AML. γ-Catenin was significantly overexpressed in AML patients compared to healthy donors. The γ-catenin expression in AML patients with lower white blood cells (<30×109/L) was significantly higher than those with higher white blood cells (≥30×109/L). The expression levels of γ-catenin in AML patients with mutated CEBPα were significantly higher than those with unmutated CEBPα. AML patients with lower γ-catenin levels were more likely to achieve complete remission compared with patients who have higher γ-catenin levels. In K562 cells, γ-catenin knockdown suppressed cellular proliferation, while the cellular migration was greatly enhanced. Moreover, knocking down of γ-catenin enhanced the cytotoxicity of decitabine in K562 cells. Our investigation has indicated a potential role of γ-catenin in the pathogenesis of AML. Keywords: γ-catenin, acute myeloid leukemia, AML, decitabine, prognosis, bone marrow, shRNA

Anahtar Kelimeler : γ-catenin, Acute Myeloid Leukemia (AML), Decitabine

ISSN: 1178-6930
Cilt: 2016
Sayı: 1
Sayfa: 3861 - 3871

20

Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

Cancer Management and Research

Yazar(lar) :

Chen X , Huang Z , Wu W , Xia R

Yıl :

2020

Wu W

Özet Ek Bilgiler

Xiaowen Chen, Zhenqi Huang, Wei Wu, Ruixiang Xia Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, People’s Republic of ChinaCorrespondence: Ruixiang Xia Email xiaruixiang@ahmu.edu.cnIntroduction: Skp2 is an E3 ubiquitin ligase that plays an important role in modulating tumor progression. The mechanisms underlying Skp2 in the promotion of proliferation and its function in the primary resistance to tyrosine kinase inhibitors (TKIs) in human CML remain to be determined. This study aimed to investigate the function of Skp2 in CML progression as well as its effects on TKI sensitivity.Methods: Expression of Skp2 in leukocytes from patients with CML and normal blood samples was analyzed by qRT-PCR. Cell proliferation was analyzed by EdU incorporation and cell counting assays. Luciferase reporter and chromatin immunoprecipitation assays were used for examination of the effects of CREB on Skp2 expression. The apoptosis in vitro of K562 cells was analyzed by MTT and caspase 3/7 activity assays.Results: The present study demonstrates that Skp2 was expressed at a higher level in patients with CML compared with healthy donors, and the elevated expression of Skp2 is critical for CML cell proliferation. Mechanistically, Skp2 was transcriptionally upregulated by CREB responsive to the PI3K/Akt signaling pathway. Furthermore, inhibition of Skp2 expression by shRNAs or blocking the PI3K/Akt/CREB pathway greatly enhances the sensitivity of CML cells to Imatinib treatment.Conclusion: We conclude that the PI3K/Akt/CREB axis regulates the sensitivity of K562 cells to Imatinib via mediating Skp2 expression. The present study revealed an unknown role of Skp2 in CML progression and provided new aspects on the Skp2-modulated TKI sensitivity in CML, contributing to the development of potential therapeutic anticancer drugs.Keywords: Skp2, PI3K/Akt, CREB, Imatinib

Anahtar Kelimeler : pi3k/akt, imatinib

ISSN: 1179-1322
Cilt: 12
Sayfa: 4777 - 4787

Sınıflandırma :

Biyotıp %100

Translasyon Sonrası Değişiklik %100

21

High-resolution diffusion MRI at 7T using a three-dimensional multi-slab acquisition

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Wu W , Poser BA , Douaud GLA , Frost SR , In M-H , Speck O , Koopmans PJ , Miller KL

Yıl :

2016

Wu W

Özet Ek Bilgiler

High-resolution diffusion MRI can provide the ability to resolve small brain structures, enabling investigations of detailed white matter architecture. A major challenge for in vivo high-resolution diffusion MRI is the low signal-to-noise ratio. In this work, we combine two highly compatible methods, ultra-high field and three-dimensional multi-slab acquisition to improve the SNR of high-resolution diffusion MRI. As each kz plane is encoded using a single-shot echo planar readout, scan speeds of the proposed technique are similar to the commonly used two-dimensional diffusion MRI. In-plane parallel acceleration is applied to reduce image distortions. To reduce the sensitivity of auto-calibration signal data to subject motion and respiration, several new adaptions of the fast low angle excitation echo-planar technique (FLEET) that are suitable for 3D multi-slab echo planar imaging are proposed and evaluated. A modified reconstruction scheme is proposed for auto-calibration with the most robust method, Slice-FLEET acquisition, to make it compatible with navigator correction of motion induced phase errors. Slab boundary artefacts are corrected using the nonlinear slab profile encoding method recently proposed by our group. In vivo results demonstrate that using 7T and three-dimensional multi-slab acquisition with improved auto-calibration signal acquisition and nonlinear slab boundary artefacts correction, high-quality diffusion MRI data with ~1 mm isotropic resolution can be achieved.

Anahtar Kelimeler : diffusion, multi-slab, 7t, high resolution, tractography, 3d

Sınıflandırma :

Mühendislik %44

Desen tanıma %61

Bilgisayar Bilimi %27

Görüntü İşleme ve Bilgisayarla Görme %100

22

A 3D k‐space Fourier encoding and reconstruction framework for simultaneous multi‐slab acquisition

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Dai E , Wu Y , Wu W , Guo R , Liu S , Miller KL , Zhang Z , Guo H

Yıl :

2019

Wu W

Özet Ek Bilgiler

PURPOSE:To propose a novel 3D k-space Fourier encoding and reconstruction framework for simultaneous multi-slab (SMSlab) acquisition and demonstrate its efficacy in high-resolution imaging. METHODS:First, it is illustrated in theory how the inter-slab gap interferes with the formation of the SMSlab 3D k-space. Then, joint RF and gradient encoding are applied to remove the inter-slab gap interference and form a SMSlab 3D k-space. In vivo experiments are performed to validate the proposed theory. Acceleration in the proposed SMSlab 3D k-space is also evaluated. RESULTS:High-resolution (1.0 mm isotropic) images can be reconstructed using the proposed SMSlab 3D framework. Controlled aliasing in parallel imaging sampling and 2D GRAPPA reconstruction can also be applied in the SMSlab 3D k-space. Compared with conventional multi-slab acquisition, SMSlab exhibits better SNR maintainability (such as lower g-factors), especially at high acceleration factors. CONCLUSION:It is demonstrated that the joint application of RF and gradient encoding enables SMSlab within a 3D Fourier encoding framework. Images with high isotropic resolution can be reconstructed, and further acceleration is also applicable. The proposed SMSlab 3D k-space can be valuable for both high-resolution and high-efficiency diffusion and functional MRI.

Sınıflandırma :

Bilgisayar Bilimi %52

Görüntü İşleme ve Bilgisayarla Görme %69

Mühendislik %32

Desen tanıma %70

23

An apartment house in Westgate-West for M.I.T. personnel, M.I.T., Cambridge, Massachusetts

Tez

Kaynak 1:

Dissertation.com

Kaynak 2:

DSpace MIT Theses

Kaynak 3:

NDTLD Thesis

Dergi:

Dissertation.com

Yayıncı:

Dissertation.com

Yazar(lar) :

Tsun Wu W Kwan

Konu :

Architecture

Yıl :

1954

Tsun Wu W Kwan

Yayıncı Web Siteleri

Ek Bilgiler

Kaynak 1: http://www.dissertation.com/abstracts/1570867 arayıcılığı görüntüle.
Kaynak 2: http://dspace.mit.edu/handle/1721.1/76445 arayıcılığı görüntüle.
Kaynak 3: http://search.ndltd.org/show.php?id=oai%3Aunion.ndltd.org%3AMIT%2Foai%3Adspace.mit.edu%3A1721.1%2F76445&back=http%3A%2F%2Fsearch.ndltd.org%2Fsearch.php%3Fq%3D%26source_set_names%3D%26year_start%3D%26year_end%3D%26language%255B0%255D%3Denglish%26language%255B1%255D%3Den_us%26start%3D1462310 arayıcılığı görüntüle.

Tez türü: Thesis

Sınıflandırma :

Dilbilim %34

Cermen Dilleri %85

Mimarlık %33

Peyzaj Mimarlığı %53

Mimarlık %27

Şehircilik %20

24

Liposomes containing glycocholate as potential oral insulin delivery systems: preparation, in vitro characterization, and improved protection against enzymatic degradation

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Nanomedicine

Yazar(lar) :

Niu M , Lu Y , Hovgaard L , Wu W

Yıl :

2011

Wu W

Özet Ek Bilgiler

Mengmeng Niu1, Yi Lu1, Lars Hovgaard2, Wei Wu11School of Pharmacy, Fudan University, Shanghai, People's Republic of China; 2Oral Formulation Development, Novo Nordisk A/S, Maalov, DenmarkBackground: Oral delivery of insulin is challenging and must overcome the barriers of gastric and enzymatic degradation as well as low permeation across the intestinal epithelium. The present study aimed to develop a liposomal delivery system containing glycocholate as an enzyme inhibitor and permeation enhancer for oral insulin delivery.Methods: Liposomes containing sodium glycocholate were prepared by a reversed-phase evaporation method followed by homogenization. The particle size and entrapment efficiency of recombinant human insulin (rhINS)-loaded sodium glycocholate liposomes can be easily adjusted by tuning the homogenization parameters, phospholipid:sodium glycocholate ratio, insulin:phospholipid ratio, water:ether volume ratio, interior water phase pH, and the hydration buffer pH.Results: The optimal formulation showed an insulin entrapment efficiency of 30% ± 2% and a particle size of 154 ± 18 nm. A conformational study by circular dichroism spectroscopy and a bioactivity study confirmed the preserved integrity of rhINS against preparative stress. Transmission electron micrographs revealed a nearly spherical and deformed structure with discernable lamella for sodium glycocholate liposomes. Sodium glycocholate liposomes showed better protection of insulin against enzymatic degradation by pepsin, trypsin, and a-chymotrypsin than liposomes containing the bile salt counterparts of sodium taurocholate and sodium deoxycholate.Conclusion: Sodium glycocholate liposomes showed promising in vitro characteristics and have the potential to be able to deliver insulin orally.Keywords: liposomes, glycocholate, insulin, enzymatic degradation, oral

Cilt: 2011
Sayı: default
Sayfa: 1155 - 1166

Sınıflandırma :

Kimya %89

Biyoteknoloji %34

Kromatografi %24

25

Midkine Is a Potential Urinary Biomarker for Non-Invasive Detection of Bladder Cancer with Microscopic Hematuria

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

OncoTargets and Therapy

Yazar(lar) :

Lin H , Zhou Q , Wu W , Ma Y

Yıl :

2020

Wu W

Özet Ek Bilgiler

Hao Lin,1 Qingwen Zhou,1 Weichu Wu,1 Yulin Ma1,2 1Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, People’s Republic of China; 2Department of Urology, Hongsen Hospital of Harbin Medical University, Sanya, Hainan 572000, People’s Republic of ChinaCorrespondence: Yulin Ma Email mayulin2017@163.com Background: To determine the role of Midkine (MDK) in non-invasive detection of bladder cancer (Bca) and the relationship with Ki67.Methods: Sixty-five Bca patients and 55 non-Bca patients or healthy volunteers were enrolled and voided urine samples were prospectively obtained on the first day of enrollment. Tissue samples were collected by surgery. MDK and Ki67 expressions were analyzed by immunohistochemistry and Western Blot (WB). Specificity and sensitivity of MDK mRNA testing in the detection of Bca were determined by Receiver Operating Characteristic curve (ROC). The relationship between MDK and Ki67 was also assessed.Results: MDK was overexpressed in Bca tissues than that in the non-cancer tissues. The specificity and sensitivity for MDK mRNA testing in urine in the identification of Bca was 80% and 72.3%. MDK detected 85.7% of high-grade tumors, 87.5% of muscle-invasive tumors and 79.4% of tumors larger than 3 cm in patients without gross hematuria. Microscopic hematuria may even increase the detection rate of Bca by MDK testing. Furthermore, the correlation of MDK and Ki67 was found positive.Conclusion: MDK was overexpressed in Bca tissues and positively correlated with Ki67. MDK might be a potential biomarker for the detection of Bca, especially for those without gross hematuria but with microscopic hematuria.Keywords: Midkine, non-invasive detection, bladder cancer, biomarker, Ki67

Anahtar Kelimeler : midkine, non-invasive detection, bladder cancer, biomarker

ISSN: 1178-6930
Cilt: 12
Sayfa: 11765 - 11775

Sınıflandırma :

Tıp ve Halk Sağlığı %99

Hepatoloji %84

26

Multiscale coherence regularization reconstruction using a nonlocal operator for fast variable-density spiral imaging

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Fang S , Li L , Wu W , Wei J , Zhang B , Kim D-H , Yuan C , Guo H

Yıl :

2017

Wu W

Özet Ek Bilgiler

Purpose Nonlinear reconstruction can suppress pseudo-incoherent aliasing artifacts from variable-density spiral (VDS) trajectories when interleaves are undersampled for acquisition acceleration during MR imaging. However, large-scale aliasing artifact suppression often conflicts with fine-scale structure preservation and may cause deterioration of image quality in the reconstructed images. To address this issue, a sequential, multiscale coherence regularization algorithm using a nonlocal operator (mCORNOL) is proposed. Methods mCORNOL is formed by exploiting the scale-control capacity of nonlocal operators in image structure measurement. By changing the scale of the structure measurement, the smoothing constraint scales can be adjusted. Starting with a large value, mCORNOL gradually reduces the smoothing constraint scale until it reaches the same level as the noise. Therefore, the large-scale smoothing constraint dominates the first few iterations of the reconstruction and removes aliasing artifacts as well as fine structures. In the following iterations, the smoothing constraint is restricted to a smaller and smaller scale, so the fidelity term progressively dominates and restores lost structures. Thus, aliasing artifact removal and structure preservation can be decoupled and achieved sequentially, which alleviates the conflicts between them. Results Numerical simulation and in vivo experiment results demonstrate the superiority of mCORNOL for aliasing artifact suppression and image structure preservation at high reduction factors, compared to SENSE, Total Variation and the original CORNOL reconstruction. Conclusions mCORNOL reconstruction provides an effective way to improve image quality for undersampled VDS acquisitions.

Anahtar Kelimeler : nonlinear reconstruction, variable-density spiral, parallel imaging, structure preservation, multiscale cornol

Sınıflandırma :

Bilgisayar Bilimi %44

Görüntü İşleme ve Bilgisayarla Görme %67

Matematik %41

Görselleştirme %41

27

Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite.

Dergi Makalesi

Kaynak :

Ora Articles

Dergi:

ORA - Oxford University Research Archive

Yayıncı:

ORA - Oxford University Research Archive

Yazar(lar) :

Nancollas GH , Tang R , Phipps RJ , Henneman Z , Gulde S , Wu W , Mangood A , Russell RG , Ebetino FH

Yıl :

2006

Wu W

Özet Ek Bilgiler