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1
Comparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
OncoTargets and Therapy
Yazar(lar) :
Deng S , Lin S , Shen J , Zeng Y
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Shu Deng,1 Shenyun Lin,1 Jianping Shen,1 Yuqing Zeng2 1Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310006, China; 2Department of Orthopedics, TongDe Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China Objective: To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL). Methods: Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible trials comparing CHOP with CHOPE for treatment of PTCL. The following outcomes of PTCL patients were considered: complete response (CR), partial response (PR), overall response rate (ORR), and adverse events (AEs; grade ≥3). Risk ratios (RRs) were appropriately derived from fixed-effects or random-effects models. Results: A total of five prospective or retrospective articles with 1,560 patients were elected for the meta-analysis. There were no significant differences in CR (RR =1.11, 95% CI: 0.73–1.67, P=0.632), PR (RR =1.40, 95% CI: 0.52–3.76, P=0.504), and ORR (RR =1.25, 95% CI: 0.93–1.69, P=0.146) between the CHOP and CHOPE groups. However, AEs including anemia (RR =1.69, 95% CI: 1.33–2.16, P<0.001) and thrombocytopenia (RR =1.43, 95% CI: 1.15–1.77, P=0.001) were significantly increased in CHOPE group compared to that in CHOP group. Conclusion: Meta-analysis suggested that there were no differences in therapeutic effect for patients with PTCL between CHOP and CHOPE groups with regards to CR, PR, and ORR, whereas the CHOPE group had significantly increased AEs (anemia and thrombocytopenia) compared to CHOP group. Keywords: peripheral T-cell lymphoma, complete response, partial response, overall response rate, adverse events
Anahtar Kelimeler : Peripheral T cell lymphomas, Etoposide, Meta-analysis
ISSN: 1178-6930
Cilt: 12
Sayfa: 2335 - 2342
2
Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Zhai B , Zeng Y , Zeng Z , Zhang N , Li C , Zeng Y , You Y , Wang S , Chen X , Sui X , Xie T
Yıl :
2018
Zeng Y Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Bingtao Zhai,1 Yiying Zeng,2–5 Zhaowu Zeng,2–4 Nana Zhang,2–4 Chenxi Li,2–4 Yijun Zeng,2–4 Yu You,1 Shuling Wang,2–4 Xiabin Chen,2–4 Xinbing Sui,2–4 Tian Xie2–4 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China; 2Holistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, China; 3Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Hangzhou, Zhejiang, China; 4Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou, Zhejiang, China; 5College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China Abstract: β-elemene is a noncytotoxic Class II antitumor drug extracted from the traditional Chinese medicine Curcuma wenyujin Y. H. Chen et C. Ling. β-elemene exerts its effects by inhibiting cell proliferation, arresting the cell cycle, inducing cell apoptosis, exerting antiangiogenesis and antimetastasis effects, reversing multiple-drug resistance (MDR), and enhancing the immune system. Elemene injection and oral emulsion have been used to treat various tumors, including cancer of the lung, liver, brain, breast, ovary, gastric, prostate, and other tissues, for >20 years. The safety of both elemene injection and oral emulsion in the clinic has been discussed. Recently, the secondary development of β-elemene has attracted the attention of researchers and made great progress. On the one hand, studies have been carried out on liposome-based systems (including solid lipid nanoparticles [SLNs], nanostructured lipid carriers [NLCs], long-circulating liposomes, active targeting liposomes, and multidrug-loaded liposomes) and emulsion systems (including microemulsions, self-emulsion drug delivery systems [SEDDSs], and active targeting microemulsion) to solve the issues of poor solubility in water, low bioavailability, and severe phlebitis, as well as to improve antitumor efficacy. The pharmacokinetics of different drug delivery systems of β-elemene are also summarized. On the other hand, a number of highly active anticancer β-elemene derivatives have been obtained through modification of the structure of β-elemene. This review focuses on the two drug delivery systems and derivatives of β-elemene for cancer therapy. Keywords: β-elemene, pharmacokinetics, drug delivery system, derivative, safety
Anahtar Kelimeler : β-elemene, pharmacokinetics, drug delivery system, derivative, safety
Cilt: 13
Sayfa: 6279 - 6296
Sınıflandırma :
Apoptoz %89
3
Statins induce cell apoptosis through a modulation of AKT/FOXO1 pathway in prostate cancer cells
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Deng JL , Zhang R , Zeng Y , Zhu YS , Wang G
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Jun-Li Deng,1,2 Rui Zhang,1,2 Ying Zeng,1,2 Yuan-Shan Zhu,3 Guo Wang1,21Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China; 2Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, People’s Republic of China; 3Department of Medicine, Weill Cornell Medicine, NY, NY 10065, USABackground: In recent years, statins have been frequently investigated in neoplasms. However, the potential roles of statins on prostate cancer cells and the underlying mechanisms have not been fully elucidated. In current study, we explored the effect and molecular mechanism of statins on cell proliferation and apoptosis in prostate cancer cells.Methods: Prostate cancer cell were treated with gradient doses of simvastatin and fluvastatin for 24–72 h. Cell proliferation was analyzed by using MTS assay and colony formation. Cell apoptosis was measured by Hoechst staining, flow cytometry and caspase-3 activity. Western blotting was used to evaluate the proteins levels.Results: Both simvastatin and fluvastatin produced a dose- and time-dependent inhibition of cell viability and colony formation while a promotion of cell apoptosis as evident with increases in caspase-3 activity, cleaved-caspase-3, cleaved-caspase-8 and cleaved-PARP levels in PC3 cells. Similar statin effects were observed in DU145 prostate cancer cells. Furthermore, statins produced a time- and dose-dependent reduction of phosphorylated-AKT and phosphorylated-FOXO1 levels in PC3 cells, and pretreatment of cells with an AKT phosphorylation inhibitor, MK2206, potentiated statins’ effect.Conclusion: Statins decrease cell proliferation and induce cell apoptosis, probably mediated via a downregulation of AKT/FOXO1 phosphorylation in prostate cancer cells, which may have a potential benefit in prostate cancer prevention and therapy.Keywords: statins, prostate cancer, apoptosis, AKT/FOXO1, pathway
Anahtar Kelimeler : Statins, prostate cancer, apoptosis, AKT/FOXO1, pathway
ISSN: 1179-1322
Cilt: 11
Sayfa: 7231 - 7242
Sınıflandırma :
Biyotıp %100
Apoptoz %73
4
The Influencing Factors of Health-Seeking Preference and Community Health Service Utilization Among Patients in Primary Care Reform in Xiamen, China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Patient Preference and Adherence
Yazar(lar) :
Zeng Y , Xu W , Chen L , Chen F , Fang Y
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Yanbing Zeng,1 Weiqian Xu,1 Lele Chen,2 Fan Chen,3 Ya Fang1 1State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Key Laboratory of Health Technology Assessment of Fujian Province University, School of Public Health, Xiamen University, Xiamen, Fujian, People’s Republic of China; 2School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu, People’s Republic of China; 3Xiang’An Hospital of Xiamen University, Xiamen, Fujian, People’s Republic of ChinaCorrespondence: Ya FangSchool of Public Health, Xiamen University, Xiang’an Nan Road, Xiang’an District, Xiamen, Fujian 361102, People’s Republic of ChinaTel +86 592-2880636Fax +86 592-2880639Email fangya@xmu.edu.cnIntroduction: Patients often seek healthcare at general hospitals rather than at community healthcare centres (CHCs) which leads to inefficiency of health services. The primary healthcare reform developed by Xiamen has proven to break through the barriers of hierarchical diagnosis and treatment. The influencing factors of health-seeking behaviours of patients in the Xiamen reform, however, are unclear.Objective: This study aimed to assess patients’ healthcare-seeking preferences and CHCs utilization, and identify influencing factors among patients affected by the Xiamen reform.Methods: A cross-sectional study composed of 2200 individuals with hypertension or diabetes was conducted in association with Xiamen’s reform. The choice of health institutions was used to measure health-seeking preference. The probability and frequency of outpatient service use were used to measure CHC utilization. The social ecological model and two-part model were employed to examine influencing factors.Results: As high as 72.5% of the subjects, including those who were under 60 years old, had low education level, with long disease duration, good self-report health and low household income expressed a preference for CHC (P< 0.05). Also, participants who had good-condition CHCs (χ2=6.736, P=0.010), joined in three-in-one chronic disease management (χ2=81.615, P< 0.01) and were insured by medical insurance (χ2=21.142, P< 0.01) significantly preferred to visit CHCs for treatment. In addition, patients who had a preference for CHC utilized many more CHCs (P< 0.01). Analysis of influencing factors found that education, self-reported health, smoking, household income, condition of the CHC, whether the patient had joined the healthcare reform and whether the patient had medical insurance were important factors affecting health-seeking preference and CHC utilization (P< 0.05).Conclusion: The Xiamen healthcare reform made some achievements in improving CHC utilization. However, certain challenges remain. The government should further strengthen CHCs, deepen and expand healthcare reform, and make efforts to guide reasonable healthcare-seeking behaviour and improve the efficiency of primary health systems.Keywords: health-seeking preference, community health services utilization, social ecological determinants, chronic diseases, primary care reform
Anahtar Kelimeler : health-seeking preference, community health services utilization, social ecological determinants, chronic diseases, primary care reform
ISSN: 1177-889X
Cilt: 14
Sayfa: 653 - 662
Sınıflandırma :
5
Exercise assessments and trainings of pulmonary rehabilitation in COPD: a literature review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of COPD
Yazar(lar) :
Zeng Y , Jiang F , Chen Y , Chen P , Cai S
Yıl :
2018
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Yuqin Zeng,1–3 Fen Jiang,1–3 Yan Chen,1–3 Ping Chen,1–3 Shan Cai1–3 1Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China; 2Research Unit of Respiratory Disease, Central South University, Changsha, Hunan 410011, China; 3Hunan Diagnosis and Treatment Center of Respiratory Disease, Changsha, Hunan 410011, China Abstract: Skeletal muscle dysfunction leads to reduction in activity in patients with COPD. As an essential part of the management of COPD, pulmonary rehabilitation (PR) alleviates dyspnea and fatigue, improves exercise tolerance and health-related quality of life, and reduces hospital admissions and mortality for COPD patients. Exercise is the key component of PR, which is composed of exercise assessment and training therapy. To evaluate PR’s application in clinical practice, this article summarizes the common methods of exercise measurement and exercise training for patients with COPD. Exercise assessments should calculate patients’ symptoms, endurance, strength, and health-related quality of life. After calculation, detailed exercise therapies should be developed, which may involve endurance, strength, and respiratory training. The detailed exercise training of each modality is mentioned in this review. Although various methods and therapies of PR have been used in COPD patients, developing an individualized exercise training prescription is the target. More studies are warranted to support the evidence and examine the effects of long-term benefits of exercise training for patients with COPD in each stage. Keywords: COPD, pulmonary rehabilitation, exercise assessment, exercise training
Anahtar Kelimeler : pulmonary rehabilitation, exercise assessment, exercise training
Cilt: 13
Sayfa: 2013 - 2023
Sınıflandırma :
6
Manganese Oxide Nanoparticles As MRI Contrast Agents In Tumor Multimodal Imaging And Therapy
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Cai X , Zhu Q , Zeng Y , Zeng Q , Chen X , Zhan Y
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Xiaoxia Cai, Qingxia Zhu, Yun Zeng, Qi Zeng, Xueli Chen, Yonghua Zhan Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Yonghua ZhanEngineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710071, People’s Republic of ChinaTel +86 29 81891070Fax +86 29 81891060Email yhzhan@xidian.edu.cnAbstract: Contrast agents (CAs) play a crucial role in high-quality magnetic resonance imaging (MRI) applications. At present, as a result of the Gd-based CAs which are associated with renal fibrosis as well as the inherent dark imaging characteristics of superparamagnetic iron oxide nanoparticles, Mn-based CAs which have a good biocompatibility and bright images are considered ideal for MRI. In addition, manganese oxide nanoparticles (MONs, such as MnO, MnO2, Mn3O4, and MnOx) have attracted attention as T1-weighted magnetic resonance CAs due to the short circulation time of Mn(II) ion chelate and the size-controlled circulation time of colloidal nanoparticles. In this review, recent advances in the use of MONs as MRI contrast agents for tumor detection and diagnosis are reported, as are the advances in in vivo toxicity, distribution and tumor microenvironment-responsive enhanced tumor chemotherapy and radiotherapy as well as photothermal and photodynamic therapies.Keywords: manganese oxide nanoparticles, MRI, multimodal imaging, contrast agent, tumor therapy
Anahtar Kelimeler : Manganese oxide nanoparticles, Multimodal imaging, Contrast agent, Tumor therapy
Cilt: 14
Sayfa: 8321 - 8344
Sınıflandırma :
7
Serum lipid profiles and post-stroke depression in acute ischemic stroke patients
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Neuropsychiatric Disease and Treatment
Yazar(lar) :
Shen H , Tu X , Luan X , Zeng Y , He J , Tang W
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Huiping Shen,1,2,* Xinjie Tu,1,* Xiaoqian Luan,1 Yaying Zeng,1,2 Jincai He,1 Wenjie Tang21Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, People’s Republic of China; 2First School of Clinical Medicie, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China*These authors contributed equally to this work Purpose: Post-stroke depression (PSD) is a psychiatric complication after stroke that leads to poorer stroke outcomes. Recent observational studies have indicated that lipid profiles were associated with a higher risk of stroke and depression. This study aims to further explore the possible relationship between serum lipid profiles and the development of PSD.Methods: A total of 373 acute ischemic stroke patients were examined. Serum lipid profiles including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), apolipoprotein A1 (Apo A1) and apolipoprotein B (Apo B) were measured within 24 hrs of admission. Depression symptoms were assessed by the 17-item Hamilton Depression Scale (HAMD-17) at the one-month follow-up, and HAMD scores ≥7 indicated a diagnosis of PSD.Results: A total of 114 patients were diagnosed with PSD at the one-month follow-up, for a percentage of 30.6%. There were significant differences in HDL-C levels (P<0.001), LDL-C levels (P=0.002) and the LDL/HDL ratio (P<0.001) between the PSD and non-PSD groups, but no differences were observed in TGs, TC, Apo A1 or Apo B. Low serum HDL-C levels (r = −0.157, P<0.001) and elevated LDL-C levels (r =0.139, P=0.002) and the LDL/HDL ratio (r =0.227, P<0.001) were associated with HAMD scores. After adjusting for the NIHSS score, BI score, mRS score and alcohol consumption in the logistic analysis, low HDL-C levels and the highest quartile (≥3.07) of the LDL/HDL ratio were independently associated with the development of PSD (OR =0.250, 95% CI, 0.077–0.813, P=0.021 and OR =1.874, 95% CI, 1.050–3.347, P=0.034, respectively).Conclusion: Decreased levels of HDL-C and elevated levels of LDL/HDL ratio are associated with PSD. HDL-C and the LDL/HDL ratio are independent predictors of PSD.Keywords: lipid profiles, high-density lipoprotein cholesterol, LDL/HDL ratio, post-stroke depression
Anahtar Kelimeler : Lipid profiles, high-density lipoprotein cholesterol, LDL/HDL ratio, post-stroke depression
Cilt: 15
Sayfa: 1573 - 1583
8
Effect of solvent concentration on morphology of electrospun Bombyx mori silk
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
NISCAIR Online Periodicals Repository
Dergi:
NISCAIR-CSIR, India
Yayıncı:
NISCAIR-CSIR, India
Yazar(lar) :
Kamalha E , Zheng Y S , Zeng Y C , Mwasiagi J I
Yıl :
2014
Zeng Y C
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
Effect of solvent (LiBr and CaCl2:methanol:water::1:2:8) concentration on the morphology of ectrospun Bombyx mori silk has been studied. Scanning electron microscopy is used to elucidate the appearance and diameter of the nanofibres. Concentrations of solvents in the range of 25-30% are found to yield fibres with fewer beads, and a better distribution of diameter. At lower concentrations, the fibres are found scattered and more discontinuous, although they appear finer as compared to the fibres produced using higher solvent concentration. The two solvents are found to yield similar results.
Anahtar Kelimeler : Bombyx mori, Electrospinning, Nanofibres, Silk fibroin, Article

Sayfa: 201-203
ISSN: 0975-1025 (Online); 0971-0426 (Print)
9
Decreased miR-503 expression in gastric cancer is inversely correlated with serum carcinoembryonic antigen and acts as a potential prognostic and diagnostic biomarker
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
OncoTargets and Therapy
Yazar(lar) :
Wu D , Cao G , Huang Z , Jin K , Hu H , Yu J , Zeng Y
Yıl :
2016
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Daoyi Wu, Gaojian Cao, Zhenfeng Huang, Kai Jin, Haowei Hu, Jie Yu, Yu Zeng Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, People’s Republic of China Background: Altered expression of miR-503 has been linked to human carcinogenesis. In this present study, we aimed to detect the potential for miR-503 as a novel biomarker for gastric cancer (GC) patients.Materials and methods: The relative mRNA level of miR-503 in serum and tissue of 68 GC patients and serum of 32 healthy volunteers was determined by real-time reverse transcription quantitative polymerase chain reaction. Results: The miR-503 level was significantly lower in the tissue and serum of GC than their counterparts (all P<0.01). Downregulation of miR-503 was found to be corrected with more aggressive tumor. Patients in the high-miR-503 group showed significantly better overall survival compared to the low-miR-503 group (P=0.021). The serum miR-503 level in GC was inversely correlated with carcinoembryonic antigen (CEA) (r=−0.624, P<0.001). Furthermore, the area under the receiver operating characteristic curve for miR-503 discriminating GC patients from healthy individuals was 0.889 (P=0.006), with a sensitivity of 96.8% and a specificity of 79.4%, higher than that of CEA (area under the receiver operating characteristic curve =0.681, P=0.048).Conclusion: The present study suggests that the expression level of miR-503 may serve as prognostic and diagnostic biomarker for GC.Keywords: microRNA, gastric cancer, diagnosis, prognosis, biomarker
Anahtar Kelimeler : microRNA, gastric cancer, diagnosis, prognosis, biomarker
ISSN: 1178-6930
Cilt: 10
Sayfa: 129 - 135
10
Design of polyaspartic acid peptide-poly (ethylene glycol)-poly (ε-caprolactone) nanoparticles as a carrier of hydrophobic drugs targeting cancer metastasized to bone
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Liu JS , Zeng Y , Shi S , Xu L , Zhang HL , Pathak JL , Pan Y
Yıl :
2017
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Jinsong Liu,1,* Youyun Zeng,1,* Shuai Shi,2 Lihua Xu,3 Hualin Zhang,4 Janak L Pathak,5 Yihuai Pan1 1School and Hospital of Stomatology, 2Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, 3The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 4College of Stomatology, Ningxia Medical University, Yinchuan, 5School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: Treatment of cancer metastasized to bone is still a challenge due to hydrophobicity, instability, and lack of target specificity of anticancer drugs. Poly (ethylene glycol)-poly (e-caprolactone) polymer (PEG-PCL) is an effective, biodegradable, and biocompatible hydrophobic drug carrier, but lacks bone specificity. Polyaspartic acid with eight peptide sequences, that is, (Asp)8, has a strong affinity to bone surface. The aim of this study was to synthesize (Asp)8-PEG-PCL nanoparticles as a bone-specific carrier of hydrophobic drugs to treat cancer metastasized to bone. 1H nuclear magnetic resonance, Fourier transform infrared spectroscopy, and transmission electron microscopy data showed that (Asp)8-PEG-PCL nanoparticles (size 100 nm) were synthesized successfully. (Asp)8-PEG-PCL nanoparticles did not promote erythrocyte aggregation. Fluorescence microscopy showed clear uptake of Nile red-loaded (Asp)8-PEG-PCL nanoparticles by cancer cells. (Asp)8-PEG-PCL nanoparticles did not show cytotoxic effect on MG63 and human umbilical vein endothelial cells at the concentration of 10–800 µg/mL. (Asp)8-PEG-PCL nanoparticles bound with hydroxyapatite 2-fold more than PEG-PCL. Intravenously injected (Asp)8-PEG-PCL nanoparticles accumulated 2.7-fold more on mice tibial bone, in comparison to PEG-PCL. Curcumin is a hydrophobic anticancer drug with bone anabolic properties. Curcumin was loaded in the (Asp)8-PEG-PCL. (Asp)8-PEG-PCL showed 11.07% loading capacity and 95.91% encapsulation efficiency of curcumin. The curcumin-loaded (Asp)8-PEG-PCL nanoparticles gave sustained release of curcumin in high dose for >8 days. The curcumin-loaded (Asp)8-PEG-PCL nanoparticles showed strong antitumorigenic effect on MG63, MCF7, and HeLa cancer cells. In conclusion, (Asp)8-PEG-PCL nanoparticles were biocompatible, permeable in cells, a potent carrier, and an efficient releaser of hydrophobic anticancer drug and were bone specific. The curcumin-loaded (Asp)8-PEG-PCL nanoparticles showed strong antitumorigenic ability in vitro. Therefore, (Asp)8-PEG-PCL nanoparticles could be a potent carrier of hydrophobic anticancer drugs to treat the cancer metastasized to bone. Keywords: bone-targeting nanoparticles, polyaspartic acid peptides, PEG-PCL, cancer metastasized to bone, hydrophobic anticancer drug, curcumin
Anahtar Kelimeler : Bone targeting nanoparticles, Poly-aspartic acid peptides, PEG-PCL, Cancer metastasized to bone, Hydrophobic anti-cancer drug
Cilt: 12
Sayfa: 3561 - 3575
11
Fibrous sheath interacting protein 1 overexpression is associated with unfavorable prognosis in bladder cancer: a potential therapeutic target
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
OncoTargets and Therapy
Yazar(lar) :
Sun M , Zhao W , Zeng Y , Zhang D , Chen Z , Liu C , Wu B
Yıl :
2017
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Ming Sun,1 Wenyan Zhao,2 Yuecan Zeng,3 Di Zhang,4 Zhaofu Chen,1 Caigang Liu,5 Bin Wu1 1Department of Urology, 2Department of General Surgery, 3Department of Medical Oncology, Shengjing Hospital of China Medical University, 4Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, 5Department of Breast Cancer Surgery Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China Abstract: The study aimed to investigate the clinical significance of fibrous sheath interacting protein 1 (FSIP1) in bladder cancer, and its potential relevance to the survival of patients with bladder cancer. A total of 225 surgical excised-bladder cancer tissues were collected from the patients with the follow-up data >5 years. The FSIP1 expressions were assayed using immunohistochemistry. The messenger RNA (mRNA) and/or protein levels of FSIP1 in fresh bladder tumor tissues as well as bladder cancer cell lines were measured by quantitative real-time polymerase chain reaction (PCR) and Western blotting analysis. The correlation of FSIP1 expression with clinicopathological parameters was also evaluated. Western blotting analysis revealed that FSIP1 protein was detected in 94.1% (16/17) of bladder tumor specimens and in all three bladder cancer cell lines (5637, BIU-87, and T24 in particular), with significantly higher expression than those of their controls. Quantitative real-time PCR demonstrated an increased FSIP1 mRNA expression level in bladder cancer tissues than in normal adjacent tissues (P=0.012). FSIP1 overexpression showed good correlation with tumor stage and lymph node metastasis (P=0.027 and 0.000, respectively). Positive FSIP1 expression was independently associated with an unfavorable overall and disease-free survival by multivariate Cox regression (P=0.037 and 0.019, respectively). FSIP1 overexpression is associated with unfavorable prognosis in patients with bladder cancer. Thus, FSIP1 represents a potential therapeutic or predictive target for bladder cancer. Keywords: bladder cancer, fibrous sheath interacting protein 1, prognosis, survival, metastasis
Anahtar Kelimeler : bladder cancer, fibrous sheath interacting protein 1, prognosis, survival, metastasis
ISSN: 1178-6930
Cilt: 10
Sayfa: 3949 - 3956
Sınıflandırma :
12
Hypoxia-activated prodrugs and redox-responsive nanocarriers
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Zeng Y , Ma J , Zhan Y , Xu X , Zeng Q , Liang J , Chen X
Yıl :
2018
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Yun Zeng,1,* Jingwen Ma,2,* Yonghua Zhan,1 Xinyi Xu,1 Qi Zeng,1 Jimin Liang,1 Xueli Chen1 1Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an 710071, Shaanxi Province, People’s Republic of China; 2Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, People’s Republic of China *These authors contributed equally to this work Abstract: Hypoxia is one of the marked features of malignant tumors, which is associated with several adaptation changes in the microenvironment of tumor cells. Therefore, targeting tumor hypoxia is a research hotspot for cancer therapy. In this review, we summarize the developing chemotherapeutic drugs for targeting hypoxia, including quinones, nitroaromatic/nitroimidazole, N-oxides, and transition metal complexes. In addition, redox-responsive bonds, such as nitroimidazole groups, azo-groups, and disulfide bonds, are frequently used in drug delivery systems for targeting the redox environment of tumors. Both hypoxia-activated prodrugs and redox-responsive drug delivery nanocarriers have significant effects on targeting tumor hypoxia for cancer therapy. Hypoxia-activated prodrugs are commonly used in clinical trials with favorable prospects, while redox-responsive nanocarriers are currently at the experimental stage. Keywords: antitumor drugs, hypoxia, nanoparticles, redox-sensitive, tumor therapy
Anahtar Kelimeler : Anti-tumor drugs, Hypoxia, Nanoparticles, Redox-sensitive, Tumor therapy
Cilt: 13
Sayfa: 6551 - 6574
Sınıflandırma :
13
Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
OncoTargets and Therapy
Yazar(lar) :
Zeng Y , Wang CL , Xian J , Ye Q , Qin X , Tan YW , Cao YD
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Yan Zeng1, Cheng-Long Wang2, Jie Xian1, Qian Ye3, Xue Qin1, Yi-Wen Tan1, You-De Cao1 1Department of Pathology, College of Basic Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Pathology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: You-De CaoDepartment of Pathology, College of Basic Medicine, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People’s Republic of ChinaTel +86 236 848 5789Email 420306100@qq.comPurpose: Tumors with high mutation load tend to have a stronger immune response in some tumors. The correlation between expression of programmed death ligand-1 (PD-L1), a biomarker of immune response in tumors, and p53, accepted as the most frequently mutated gene in many cancers, in triple-negative breast cancer (TNBC) has not been fully investigated in cancer patients.Materials and methods: 132 cases of TNBC and 32 cases of non-TNBC paraffin-embedded tissue sections were selected to detect the expression of PD-L1 and p53 by immunohistochemistry, and results were correlated with clinical data and survival outcomes. The staining of PD-L1 in tumor cells (TCs) and tumor-associated immune cells (TAICs) was assessed separately.Results: Strong positive correlations were observed between expression of p53 and PD-L1 both in TCs (r=0.338, P=0.000) and TAICs (r=0.186, P=0.033). The same positive correlation was found in the expression of PD-L1 in TCs and TAICs (r=0.764, P=0.000). Like p53 (P=0.024), positive rate of PD-L1 in TCs was significantly higher in TNBC than in non-TNBC (P=0.02). PD-L1 and p53 in TCs staining were significantly associated with histological grade, tumor size and Ki67 index (P<0.05). PD-L1 in TCs staining was also associated with lymphatic metastasis status (P=0.000). However, PD-L1 in TAICs was only related to histological grade in statistically (P=0.012). Kaplan–Meier survival analysis showed that positive groups of p53, PD-L1 in TCs and TAICs had a worse overall survival and a worse progression-free survival as compared with the negative groups, but marginal significance was found only in overall survival of PD-L1 in TCs and TAICs, and progression-free survival of PD-L1 in TAICs (P=0.074, 0.097, 0.068, respectively).Conclusion: Our findings suggest that positive correlation between p53 and PD-L1 in TNBC and the higher expression rates are closely correlated with some key prognostic factors and worse survival outcomes. These findings would lay the foundation for further study on the relationship of p53 and PD-L1 and the combination of mutated p53 inhibitors and PD-1/PD-L1 antibodies in TNBC.Keywords: p53, programmed death ligand-1, PD-L1, immunohistochemistry, IHC, tumor cells, TCs, tumor-associated immune cells, TAICs, triple-negative breast cancer, TNBC
Anahtar Kelimeler : P53;Programmed death ligand-1(PD-L1), Immunohistochemistry(IHC), Tumor cells(TCs), Immune cells(ICs), Triple-negative breast cancer(TNBC);
ISSN: 1178-6930
Cilt: 12
Sayfa: 7193 - 7201
14
Overexpression of Notch3 is associated with metastasis and poor prognosis in osteosarcoma patients
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Tang XF , Cao Y , Peng DB , Zhao GS , Zeng Y , Gao ZR , Lv YF , Guo QN
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Xue-Feng Tang,1 Ya Cao,1 Dong-Bin Peng,1 Guo-Sheng Zhao,2 Ying Zeng,1,3 Zi-Ran Gao,1 Yang-Fan Lv,1 Qiao-Nan Guo1 1Department of Pathology, Xinqiao Hospital, Army Medical University, Chongqing 400037, China; 2Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 3Department of Pathology, Daping Hospital, Army Medical University, Chongqing 400037, China Background: Notch signaling abnormalities are associated with the development of various tumors, including hematopoietic and epithelium-derived tumors. However, the role of Notch signaling in tumors originating from mesenchymal cells is unclear. The effect of Notch3 expression on the prognosis of osteosarcoma and its role and mechanism in osteosarcoma cells have never been reported. Materials and methods: In this study, we performed a clinicopathological analysis of 70 cases of osteosarcoma, with primary focus on survival. Osteosarcoma cell lines MTH and U2OS were used. After knockdown of Notch3 by lentiviral transfection and siRNA, the cell cycle, cell viability, and wound healing capacity were assessed. Subsequently, the Transwell assay was performed, and the expression levels of hairy and enhancer of split-1 (Hes1) and matrix metalloproteinase 7 (MMP7) were detected by RT-PCR and Western blot assay. The expression of MMP7 was also detected after knockdown of Hes1. Animal experiments were performed by injecting the cell lines MTH of Notch3 knockdown into mice tail veins and comparing the development of lung metastasis with the control group. Results: Comparison of survival curves showed that Notch3 expression significantly impacts patient survival. Additionally, multivariate analysis revealed that Notch3 is an independent prognostic factor for osteosarcoma. In in vivo experiments, osteosarcoma-associated pulmonary metastasis in nude mice was reduced after Notch3 silencing. The expression of downstream effector molecule, Hes1, and that of the invasion and metastasis-associated proteolytic enzyme, MMP7, were reduced, and MMP7 was further decreased by Hes1 knockdown in in vitro experiments. Conclusion: Notch3 is a prognostic factor for osteosarcoma and might regulate its invasion and metastasis through the downstream target gene Hes1 and effector MMP7. Keywords: osteosarcoma, prognosis, metastasis, Notch3, Hes1, MMP7
Anahtar Kelimeler : osteosarcoma, prognosis, metastasis, Notch3
ISSN: 1179-1322
Cilt: 11
Sayfa: 547 - 559
Sınıflandırma :
15
First Report of OXA-181-Producing Klebsiella pneumoniae in China
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Infection and Drug Resistance
Yazar(lar) :
Liu C , Fang Y , Zeng Y , Lu J , Sun Q , Zhou H , Shen Z , Chen G
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Congcong Liu,1 Yinfei Fang,2 Yu Zeng,1 Jiayue Lu,1 Qiaoling Sun,1 Hongwei Zhou,1 Zhangqi Shen,3 Gongxiang Chen1 1Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang, Hangzhou, People’s Republic of China; 2Department of Clinical Laboratory, Jinhua Municipal Central Hospital, Zhejiang, Jinhua, People’s Republic of China; 3Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaCorrespondence: Gongxiang ChenDepartment of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, 88 Jiefang Road, Hangzhou 310009, People’s Republic of ChinaTel +86 571-87783646Email chengongxiang@zju.edu.cnAbstract: We present here the first report of an OXA-181-producing Klebsiella pneumoniae isolated from the fecal specimen of a patient in China. The OXA-181-encoding gene blaOXA-181 was located on a 51 kb IncX3-type plasmid. Conjugation assay and whole-genome sequencing analysis revealed that this transferrable plasmid in the K. pneumoniae isolate might have originated from Escherichia coli and have the potential to mediate the spread of blaOXA-181.Keywords: OXA-181, Klebsiella pneumoniae, IncX3 plasmid, China, human
Anahtar Kelimeler : oxa-181, klebsiella pneumoniae, incx3 plasmid, china, human
ISSN: 1178-6973
Cilt: 13
Sayfa: 995 - 998
Sınıflandırma :
Viroloji %99
16
Morphological and molecular characterization of two isolates of Paratrichodorus porosus from Shenzhen, China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Helminthologia
Yazar(lar) :
Zeng Y. , Ye W. , Yang L. , Huang Y. , Zhao K. , Zhang Z. , Liang H. , Kerns J.
Yıl :
2014
Zeng Y.
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.2478/s11687-014-0248-1
Anahtar Kelimeler : Paratrichodorus porosus, Acacia mangium, Gleichenia linearis, 18S small subunit rDNA, 28S large subunit rDNA, stubby-root nematode, taxonomy
Cilt: 51
Sayı: 4
Sayfa: 323 - 330
Sınıflandırma :
17
Multi-Layered Polyamide/Collagen Scaffolds with Topical Sustained Release of N-Acetylcysteine for Promoting Wound Healing
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Hou J , Chen L , Zhou M , Li J , Liu J , Fang H , Zeng Y , Sun J , Wang Z
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Jinfei Hou,1,2,* Lifeng Chen,1,2,* Muran Zhou,1,2 Jialun Li,1,2 Jian Liu,1,2 Huimin Fang,1,2 Yuyang Zeng,1,2 Jiaming Sun,1,2 Zhenxing Wang1,2 1Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Wuhan Clinical Research Center for Superficial Organ Reconstruction, Wuhan 430022, China*These authors contributed equally to this workCorrespondence: Jiaming Sun; Zhenxing Wang Email sunjm1592@sina.com; benjamin.wzx@163.comBackground: Impaired wound healing might be associated with many issues, especially overactive of reactive oxygen species (ROS), deficiency of blood vessels and immature of epidermis. N-acetylcysteine (NAC), as an antioxidant, could solve these problems by inhibiting overreactive of ROS, promoting revascularization and accelerating re-epithelialization. How to deliver NAC in situ with a controllable releasing speed still remain a challenge.Materials and Methods: In this study, we combined collagen (Col) with N-acetylcysteine to perform the characteristics of sustained release and chemically crosslinked Col/NAC composite with polyamide (PA) nanofibers to enhance the mechanical property of collagen and fabricated this multi-layered scaffold (PA-Col/NAC scaffold). The physical properties of the scaffolds such as surface characteristics, water absorption and tensile modulus were tested. Meanwhile, the ability to promote wound healing in vitro and in vivo were investigated.Results: These scaffolds were porous and performed great water absorption. The PA-Col/NAC scaffold could sustainably release NAC for at least 14 days. After cell implantation, PA-Col/NAC scaffold showed better cell proliferation and cell migration than the other groups. In vivo, PA-Col/NAC scaffolds could promote wound healing best among all the groups.Conclusion: The multi-layered scaffolds could obviously accelerate the process of wound healing and exert better and prolonged effects.Keywords: polyamide, sustained release, N-acetylcysteine, wound healing, multi-layered structure
Anahtar Kelimeler : polyamide, sustained release, n-acetylcysteine, wound healing, multi-layered structure
Cilt: 15
Sayfa: 1349 - 1361
Sınıflandırma :
18
Development and Validation of a Prognostic Nomogram to Predict the Long-Time Prognosis in Non-B, Non-C Hepatocellular Carcinoma
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Lin K , Huang Q , Huo Y , Zeng J , Ding Z , Guo P , Chen Z , Zeng Y , Liu J
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Kongying Lin,1,* Qizhen Huang,2,* Yuting Huo,3,* Jianxing Zeng,1 Zongren Ding,1 Pengfei Guo,4 Zhenwei Chen,4 Yongyi Zeng,1 Jingfeng Liu1,4 1Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China; 2Department of Radiation Oncology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China; 3Department of Otolaryngology, Fujian Medical Maternity and Child Care Hospital, Fuzhou 350014, People’s Republic of China; 4The Big Data Institute of Southeast Hepatobiliary Health Information, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingfeng Liu; Yongyi ZengDepartment of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Xihong Road 312, Fuzhou 350025, People’s Republic of ChinaTel/ Fax +86 591 8370 5927Email drjingfeng@126.com; lamp197311@126.comPurpose: To develop and validate a nomogram for individualized prediction of the long-term prognosis of patients with non-B, non-C hepatocellular carcinoma (NBNC-HCC) who underwent hepatectomy.Materials and Methods: Five hundred ninety-four patients who met the criteria were included in the research and randomly categorized into the training or validation cohort. The nomogram was constructed on the basis of the independent risk variables that were acquired via multivariate Cox proportional hazard regression analysis. Several complementary methods included the Harrell c-index, time-dependent areas under the receiver operating characteristic curve (tdAUC), and calibration plot, and the Kaplan–Meier curve with Log rank test were used to test predictive performance of the model. The clinical utility of the model was tested by the decision cure analysis (DCA).Results: Tumor diameter, tumor number, elevated serum gamma-glutamyl transpeptidase (GGT) level, microvascular invasion (MVI), and macrovascular invasion were independent risk factors of prognosis of NBNC-HCC. C-indexes of the nomogram were 0.702 (95% confidence interval [CI], 0.662– 0.741) in the training cohort and 0.700 (95% CI, 0.643– 0.758) in the validation cohort, and median tdAUC values of the nomogram were 0.743 (range, 0.736– 0.775) in the training cohort and 0.751 (range, 0.686– 0.793) in the validation cohort, which were both higher than those in the conventionally used Barcelona Clinic Liver Cancer staging system, American Joint Committee on Cancer, and eighth edition and the model of Zhang et al. The calibration plot depicted a good consistency between prediction of the model and observed outcome. The Kaplan–Meier curve analysis showed that the model was able to separate patients into three distinct risk subgroups. The DCA analysis also demonstrated that the nomogram was clinically useful.Conclusion: We developed and validated a nomogram that was accurate and clinically useful in patients with NBNC-HCC who underwent hepatectomy.Keywords: non-B non-C hepatocellular carcinoma, resection, prognosis, nomogram, survival
Anahtar Kelimeler : non-b non-c hepatocellular carcinoma, resection, prognosis, nomogram, survival
ISSN: 1179-1322
Cilt: 12
Sayfa: 7771 - 7781
Sınıflandırma :
19
Value of Visceral Fat Area in the Preoperative Discrimination of Peritoneal Metastasis from Gastric Cancer in Patients with Different Body Mass Index: A Prospective Study
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Huang H , Yang X , Sun J , Zhu C , Wang X , Zeng Y , Xu J , Mao C , Shen X
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
He Huang,1,* Xinxin Yang,2,* Jing Sun,2,* Ce Zhu,2 Xiang Wang,2 Yunpeng Zeng,2 Jingxuan Xu,2 Chenchen Mao,2 Xian Shen2,3 1Department of General Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenchen Mao; Xian ShenDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, No. 109 West College Road, Wenzhou, Zhejiang Province, People’s Republic of ChinaTel +86 577 8800 2709Email 578117567@qq.com; shenxian5166@gmain.comPurpose: Although peritoneal metastasis (PM) is associated with poor prognosis in gastric cancer (GC) patients, it is difficult to discriminate preoperatively. Our previous study has demonstrated visceral fat area (VFA) is a better obesity index than body mass index (BMI) in predicting abdominal metastasis. This study aimed to further explore the relationship between obesity and PM.Patients and Methods: VFA was retrieved for 859 consecutive patients undergoing radical gastrectomy between January 1, 2009, and December 31, 2013. A receiver operating characteristic curve analysis was used to determine the BMI-specific cutoff values for VFA. Univariate and multivariate analyses evaluating the risk factors for PM at different BMI levels were performed.Results: The optimal cutoff values for VFA were 67.28, 88.03, and 175.32 cm2 for low, normal, and high BMI patients, respectively, and 18 (15.52%), 220 (40.15%), and 61 (31.28%) patients were classified as having high VFA in each group. Univariate logistic regression revealed that the association between high VFA and PM was not dependent on BMI (odds ratio [OR]=9.048, P=0.007 for low BMI, OR=3.827, P< 0.001 for normal BMI, and OR=2.460, P=0.049 for high BMI). In multivariate logistic regression analysis, high VFA (OR=3.816, P< 0.001) and vascular invasion (OR=1.951, P=0.039) were independent risk factors for PM only in the normal BMI group.Conclusion: VFA only effectively predicted PM for GC patients with normal BMI, rather than those with low and high BMI. More attentions should be paid to those GC patients with high VFA and normal BMI.Keywords: gastric cancer, peritoneal metastasis, obesity, visceral fat area, body mass index
Anahtar Kelimeler : gastric cancer, peritoneal metastasis, obesity, visceral fat area, body mass index
ISSN: 1179-1322
Cilt: 12
Sayfa: 6523 - 6532
Sınıflandırma :
20
Morphological and molecular characterization of Xiphinema species from Shenzhen, China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Helminthologia
Yazar(lar) :
Zeng Y. , Ye W. , Zhang Z. , Sun H. , Yong L. , Huang Y. , Zhao K. , Liang H. , Kerns J.
Yıl :
2016
Zeng Y.
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
During a nematode biodiversity survey from 2012 to 2014 in Shenzhen, China, ten nematode populations (SZX1301–SZX1310) of Xiphinema were recovered from rhizosphere of different plants, namely Acacia mangium (SZX1306), A. confuse (SZX1309), Blechnum orientale (SZX1301, SZX1302, SZX1307, SZX1308), Litchi chinensis (SZX1304, SZX1310) in Tianxinshan and Gleichenia linearis (SZX1303, SZX1305) in Yangmeikeng environmental monitoring sites. Morphological and molecular profiles of these populations were determined. Three species of Xiphinema, i.e., X. hunaniense Wang & Wu, 1992, X. brasiliense Lordello, 1951 and X. americanum Cobb, 1913 sensu lato were identified using morphological characters and molecular data of partial 18S and 28S D2–D3 rDNA expansion segments. Four populations (SZX1301–SZX1304) were X. hunaniense, one population (SZX1305) X. brasiliense, and five populations (SZX1306–SZX1310) X. americanum s.l.. Phylogenetic analysis based on sequences of the 28S rDNA D2–D3 expansion segment revealed these three species are all distinct species and supported a close relationship with their corresponding species. This is the first report of X. hunaniense, X. brasiliense and X. americanum s.l. in their hosts except for L. chinensis.
DOI : 10.1515/helmin-2015-0068
Anahtar Kelimeler : Xiphinema spp., Acacia mangium, Acacia confuse, Blechnum orientale, Gleichenia linearis, Litchi chinensis, 28S rDNA, dagger nematode
Cilt: 53
Sayı: 1
Sayfa: 62 - 75
21
Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Li J , Zhao J , Tan T , Liu M , Zeng Z , Zeng Y , Zhang L , Fu C , Chen D , Xie T
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Jie Li,1– 4 Jiaqian Zhao,2– 5 Tiantian Tan,2– 4 Mengmeng Liu,2– 4 Zhaowu Zeng,2– 4 Yiying Zeng,2– 4 Lele Zhang,6 Chaomei Fu,1 Dajing Chen,2– 4 Tian Xie2– 4 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Holistic Integrative Pharmacy Institutes, Hangzhou Normal University, Hangzhou, Zhejiang, People’s Republic of China; 3Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China; 4Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou, Zhejiang, People’s Republic of China; 5College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 6School of Medicine, Chengdu University, Chengdu, People’s Republic of ChinaCorrespondence: Tian Xie; Zhaowu ZengHolistic Integrative Pharmacy Institutes, Hangzhou Normal University, 1378 Wenyixi Road, Hangzhou, Zhejiang 311121, People’s Republic of ChinaTel +86 5 712 886 8269Email xbs@dljg.sina.net; artgreenking@126.comAbstract: Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood–brain barrier (BBB), blood–brain tumor barriers (BBTB), brain–cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.Keywords: glioma, brain barrier, nanoparticle drug delivery system, efficacy improvement strategies, deficiencies of NDDS
Anahtar Kelimeler : glioma, brain barrier, nanoparticle drug delivery system, efficacy improvement strategies, deficiencies of ndds
Cilt: 15
Sayfa: 2563 - 2582
Sınıflandırma :
Viroloji %76
22
The Relationship Between Morning Symptoms and the Risk of Future Exacerbations in COPD
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of COPD
Yazar(lar) :
Sun T , Li X , Cheng W , Peng Y , Zhao Y , Liu C , Zeng Y , Chen Y , Cai S , Chen P
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Tian Sun,1,2 Xiaoyun Li,3 Wei Cheng,1,2 Yating Peng,1,2 Yiyang Zhao,1,2 Cong Liu,1,2 Yuqin Zeng,1,2 Yan Chen,1,2 Shan Cai,1,2 Ping Chen1,2 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Unit of Respiratory Disease, Central South University, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510000, People’s Republic of ChinaCorrespondence: Ping ChenDepartment of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital 139 Renmin Middle Road, Changsha, Hunan 410011, People’s Republic of ChinaTel +86-13873115563Fax +86 731-85295848Email pingchen0731@csu.edu.cnBackground: The morning is the most troublesome time of day for patients with chronic obstructive pulmonary disease (COPD). However, the association of morning symptoms and COPD exacerbations in longitudinal follow-up has not been studied. In this study, we mainly aimed to investigate the relationship between morning symptoms and exacerbations over a one-year follow-up period. And the secondary aim was an investigation of the association between morning symptoms and baseline clinical features.Patients and Methods: Ninety-two patients with stable COPD provided the baseline information. Morning symptoms were assessed with the Chinese version of Chronic Obstructive Pulmonary Disease Morning Symptom Diary (Ch-COPD-MSD); the median morning symptoms score was used as a cut-off to separate the study cohort in two groups. Modified Medical Research Council (mMRC), COPD assessment test (CAT), and Clinical COPD Questionnaire (CCQ) were used and exacerbation history of the previous year was recorded. Seventy-eight patients (84.8%) completed the longitudinal follow-up of exacerbations.Results: The median morning symptoms score was 30 in stable COPD patients. Morning symptoms severity was different between COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups (p< 0.001). Patients with high morning symptoms (score > 30) had higher scores of mMRC, CAT, and CCQ (p< 0.05). CAT score was an independent risk factor of morning symptoms. During follow-up, 41% of patients experienced ≥ 1 exacerbation. The frequency of severe exacerbations was higher in patients with high morning symptoms compared to patients with low morning symptoms (p< 0.005). The Ch-COPD-MSD score could predict future severe exacerbations; the area under the ROC curve was 0.751 (95% CI: 0.633– 0.868, p=0.002).Conclusion: Worse health status and more dyspnea symptom were associated with increased severity of morning symptoms. Morning symptoms were most strongly related to future severe exacerbations and could predict future exacerbations in patients with COPD.Keywords: chronic obstructive pulmonary disease, morning symptoms, future exacerbations
Anahtar Kelimeler : chronic obstructive pulmonary disease, morning symptoms, future exacerbations
Cilt: 15
Sayfa: 1899 - 1907
Sınıflandırma :
23
Preoperative Cachexia predicts poor outcomes in young rather than elderly gastric cancer patients: a prospective study
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Chen X , Zeng Y , Huang Y , Xu J , Meng W , Wang X , Zhu C , Zhu G , Mao C , Shen X
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Xiaodong Chen,1,* Yunpeng Zeng,1,* Yunshi Huang,2 Jingxuan Xu,1 Weiyang Meng,3 Xiang Wang,1 Ce Zhu,2 Guanbao Zhu,2 Chenchen Mao,1 Xian Shen1,21Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Emergency Medical, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaCorrespondence: Chenchen Mao; Xian ShenDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 West College Road, Wenzhou, Zhejiang Province, People’s Republic of ChinaTel +86 05 778 800 2709Email 578117567@qq.com; shenxian5166@gmail.com*These authors contributed equally to this workBackground: Cachexia affects nearly 50–80% of cancer patients, and most studies have only focused on elderly patients. We investigated preoperative cachexia in gastric cancer (GC) patients by age group and comprehensively analyzed the impact of preoperative cachexia on the prognosis of GC patients in all age groups.Methods: In total, 575 patients were prospectively analyzed. The effect of preoperative cachexia on overall survival (OS) in all the patients and in patients with different age groups were investigated using log-rank test and Cox proportional hazards regression, respectively.Results: In total, 35.8% (206 of 575) individuals were diagnosed with cachexia. The median survival of cachexia patients (29.2 months) was shorter than that of non-cachexia patients (35.7 months). Cachexia (HR =1.976, P<0.001), age (HR =1.811, P<0.001), readmission (HR =2.559, P<0.001), tumor size (HR =1.639, P=0.003), TNM stage (stage II: HR =2.215, P=0.017; stage III: HR =5.758, P<0.001), whole stomach cancer (HR =2.639, P<0.001), and combined operation (HR =1.598, P=0.032) were independently associated with worse OS. After grouping by age, cachexia was associated with OS in patients younger than 50 years old (HR =4.947, P=0.029), patients 51–60 years old (HR =2.232, P=0.026), and patients 61–70 years old (HR =1.806, P=0.032), but not in patients older than 71 years (HR =1.411, P=0.119). Further, cachexia only significantly affected the postoperative length of stay (P=0.015) and hospitalization costs (P=0.032) in patients younger than 50 years old.Conclusions: Preoperative cachexia predicts poor outcome in younger GC patients, and greater attention should be paid to these patients.Keywords: cachexia, gastric cancer, overall survival, younger patients
Anahtar Kelimeler : Cachexia, Gastric cancer, Overall survival, Younger patients
ISSN: 1179-1322
Cilt: 11
Sayfa: 8101 - 8110
Sınıflandırma :
24
Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of Nanomedicine
Yazar(lar) :
Kurokawa Y , Sone H , Win-Shwe TT , Zeng Y , Kimura H , Koyama Y , Yagi Y , Matsui Y , Yamazaki M , Hirano S
Yıl :
2017
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Yoshika Kurokawa,1 Hideko Sone,1 Tin-Tin Win-Shwe,1 Yang Zeng,1 Hiroyuki Kimura,2 Yosuke Koyama,1 Yusuke Yagi,2 Yasuto Matsui,3 Masashi Yamazaki,4 Seishiro Hirano1 1Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Ibaraki, 2Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 3Department of Environmental Engineering, Kyoto University Graduate School of Engineering, Kyoto, 4TIA Center Office, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan Abstract: Dendrimers have been expected as excellent nanodevices for brain medication. An amine-terminated polyamidoamine dendrimer (PD), an unmodified plain type of PD, has the obvious disadvantage of cytotoxicity, but still serves as an attractive molecule because it easily adheres to the cell surface, facilitating easy cellular uptake. Single-photon emission computed tomographic imaging of a mouse following intravenous injection of a radiolabeled PD failed to reveal any signal in the intracranial region. Furthermore, examination of the permeability of PD particles across the blood–brain barrier (BBB) in vitro using a commercially available kit revealed poor permeability of the nanoparticles, which was suppressed by an inhibitor of caveolae-mediated endocytosis, but not by an inhibitor of macropinocytosis. Physicochemical analysis of the PD revealed that cationic PDs are likely to aggregate promptly upon mixing with body fluids and that this prompt aggregation is probably driven by non-Derjaguin–Landau–Verwey–Overbeek attractive forces originating from the surrounding divalent ions. Atomic force microscopy observation of a freshly cleaved mica plate soaked in dendrimer suspension (culture media) confirmed prompt aggregation. Our study revealed poor transfer of intravenously administered cationic PDs into the intracranial nervous tissue, and the results of our analysis suggested that this was largely attributable to the reduced BBB permeability arising from the propensity of the particles to promptly aggregate upon mixing with body fluids. Keywords: PAMAM dendrimer, nanomaterial, aggregation, blood–brain barrier
Anahtar Kelimeler : PAMAM dendrimer, nanomaterial, aggregation, blood brain barrier
Cilt: 12
Sayfa: 3967 - 3975
Sınıflandırma :
25
Exploration of n-6 and n-3 Polyunsaturated Fatty Acids Metabolites Associated with Nutritional Levels in Patients with Severe Stable Chronic Obstructive Pulmonary Disease
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of COPD
Yazar(lar) :
Xue M , Cai C , Guan L , Xu Y , Lin J , Zeng Y , Hu H , Chen R , Wang H , Zhou L , Sun B
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Mingshan Xue,1,* Chuanxu Cai,2,* Lili Guan,1,* Yifan Xu,1 Jinsheng Lin,1 Yifeng Zeng,1 Haisheng Hu,1 Rongchang Chen,1 Hongman Wang,3 Luqian Zhou,1 Baoqing Sun1 1Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Laboratory Medicine, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, The Fifth Affiliated Hospital of Zunyi Medical University Zhuhai, Zhuhai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luqian Zhou; Baoqing Sun Email zhlx09@163.com; sunbaoqing@vip.163.comBackground and Objective: Severe chronic obstructive pulmonary disease (COPD) is the terminal stage of the disease characterized by declined lung function, malnutrition, and poor prognosis. Such patients cannot tolerate long-time sports rehabilitation owing to dyspnea and fail to achieve the desired therapeutic effect; therefore, increasing nutritional support will be an important strategy for them. The present study applied metabolomics technology to evaluate the correlation between serum concentrations of polyunsaturated fatty acid (PUFA) metabolites, nutritional status, and lung function in patients with COPD to provide a theoretical basis for accurate nutritional support.Materials and Methods: We enrolled 82 patients with stable severe COPD in our hospital. The general characteristics including height, weight, and lung function were recorded. Metabolomics was used to detect the concentrations of serum metabolites of n-3 and n-6 at baseline and at 24 and 52 weeks after enrollment. The correlations between nutrition level and pulmonary function and clinical indicators were evaluated.Results: The concentrations of n-3 and n-6 increased over time along with the progression of COPD. Body mass index (BMI) and percent of ideal body weight (IBW%) decreased with disease development, and BMI was found to be significantly correlated with FEV1% predicted and FEV1/FVC. Serum levels of n-6 metabolites such as linoleic acid (LA), γ-linoleic acid (GLA), and arachidonic acid (ARA) (all P < 0.01) and the n-3 metabolites such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (all P < 0.05) showed significant correlations with BMI and were closely correlated with FEV1% predicted and FEV1/FVC of lung function (all P< 0.05).Conclusion: This study demonstrates that malnutrition in patients with severe COPD is progressive and is positively correlated with n-3 and n-6 polyunsaturated fatty acids and lung function.Keywords: chronic obstructive pulmonary disease, metabolomics, nutritional level
Anahtar Kelimeler : chronic obstructive pulmonary disease, metabolimics, nutritional level
Cilt: 15
Sayfa: 1633 - 1642
Sınıflandırma :
26
Rapid evaluation of phenotypes, SNPs and results through the dbGaP CHARGE Summary Results site
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Nature
Dergi:
Nature Genetics
Yayıncı:
Springer Nature
Yazar(lar) :
Stephen S Rich , Zeng Y Wang , Anne Sturcke , Lora Ziyabari , Mike Feolo , Christopher J O'Donnell , Ken Rice , Joshua C Bis , Bruce M Psaty
Konu :
Data processing, Genome-wide association studies
Yıl :
2016
Zeng Y Wang
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
DOI : 10.1038/ng.3582
ISSN: 1546-1718
Cilt: 48
Sayı: 7
Sayfa: 702-703
Sınıflandırma :
27
A quantified risk-scoring system including the visceral fat area for peritoneal metastasis of gastric cancer
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Chen X , Chen W , Huang Y , Xu J , Zeng Y , Shi M , Xu L , Zhang W , Zhu G , Mao C , Shen X
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Xiaodong Chen,1,* Weisheng Chen,2,* Yunshi Huang,2 Jingxuan Xu,1 Yunpeng Zeng,1 Mingming Shi,2 Libin Xu,2 Weiteng Zhang,2 Guanbao Zhu,2 Chenchen Mao,1 Xian Shen1,21Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this work Background: Peritoneal metastases of gastric cancer are usually detected using imaging, However, the results of imaging modalities are not always reliable; therefore, the prediction of prognosis based on these findings is therefore inaccurate. As visceral obesity has been identified as a potential risk factor for cancer, the present study aimed to evaluate the predictive value of visceral fat area (VFA), a representative marker of visceral obesity, for peritoneal metastasis in patients with gastric cancer and to construct a reliable preoperative prediction system for peritoneal metastasis.Patients and methods: We enrolled 859 patients with gastric cancer. The VFA and other objective clinical tumor characteristics were evaluated using receiver operating characteristic (ROC) curves. Independent predictors of peritoneal metastasis were determined using logistic regression analysis; a prediction system was also evaluated using ROC curves.Results: The ROC curves indicated a VFA cutoff value of 91.00 cm2 as predictive of peritoneal metastasis. On logistic regression, visceral obesity (VFA ≥91.00 cm2) was identified as an independent predictor of peritoneal metastasis, with an area under the ROC curve of 0.659; the platelet-to-lymphocyte ratio (PLR), invasion depth, and vascular invasion were also identified as independent predictors. On integrating these predictors into a single prediction system, peritoneal metastases were more reliably predicted (area under the ROC curve=0.779).Conclusions: Visceral obesity, as defined by the VFA, effectively predicted peritoneal metastases in our cohort. Our scoring system may be a reliable instrument for identifying patients with peritoneal metastasis.Keywords: gastric cancer, peritoneal metastasis, visceral fat area, risk-scoring system
Anahtar Kelimeler : Gastric cancer, peritoneal metastasis, visceral fat area, risk-scoring system
ISSN: 1179-1322
Cilt: 11
Sayfa: 2903 - 2913
Sınıflandırma :
28
The serum proteomics tracking of hepatocellular carcinoma early recurrence following radical resection
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Cancer Management and Research
Yazar(lar) :
Liu H , Chen H , Wu X , Sun Y , Wang Y , Zeng Y , Chen G , Liu X , Xing X , Zhao B , Liu J
Yıl :
2019
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Hongzhi Liu,1,2,* Hui Chen,1,* Xiaomo Wu,3,4 Ying Sun,2 Yingchao Wang,2 Yongyi Zeng,1,2 Geng Chen,2 Xiaolong Liu,2 Xiaohua Xing,2,5 Bixing Zhao,2 Jingfeng Liu1,21Department of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350007, People’s Republic of China; 2The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China; 3Department of Biomedicine, University of Basel, Basel 4056, Switzerland; 4Dermatology Institute of Fuzhou, Dermatology Hospital of Fuzhou, Fuzhou 350025, People’s Republic of China; 5The School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, People’s Republic of China *These authors contributed equally to this work Purpose: There is still lacking of highly sensitive and specific biomarkers for the prediction of hepatocellular carcinoma (HCC) early recurrence, which has hindered further improvement of the clinical outcomes. We aim to find highly sensitive and specific biomarkers for the prediction of HCC recurrence.Patients and methods: By using isobaric tags for relative and absolute quantitation (iTRAQ)-based multidimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) technique, we have quantitatively investigated and monitored the proteome alterations of a series of serum after radical resection during the follow-up of 4 HCC patients.Results: A total of 27 differentially abundant proteins (DAPs) in serum were identified to be closely associated with the early recurrence of HCC, and these DAPs were particularly concentrated within ERK1/2 and nuclear factor-κ beta signaling pathways, suggesting the dysregulation of these two pathways played an important role in the pathological process of HCC early recurrence. Further investigation of a cohort of patients confirmed that the high serum level of PGK1 was closely associated with HCC early recurrence and poor prognosis. In addition, the serum level of PGK1 could be complementary with AFP to further improve the sensitivity and specificity for predicting the relapse of HCC.Conclusion: PGK1 might be an independent factor for the recurrence of HCC. And the PGK1 could be complementary with AFP to further improve the sensitivity and specificity in prognostic prediction of HCC relapse.Keywords: hepatocellular carcinoma, early recurrence, serum proteomics, iTRAQ, PGK1
Anahtar Kelimeler : Hepatocellular carcinoma, early recurrence, serum proteomics, iTRAQ
ISSN: 1179-1322
Cilt: 11
Sayfa: 2935 - 2946
Sınıflandırma :
29
Clinicopathological, Immunohistochemical and Molecular Genetic Study on Epithelioid Glioblastoma: A Series of Fifteen Cases with Literature Review
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
OncoTargets and Therapy
Yazar(lar) :
Zeng Y , Zhu X , Wang Y , Liu B , Yang X , Wang Q , Du J , Ma Y , Lin L , Fu P , Xiao H , Guo QN
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Ying Zeng,1,2 Xiangfeng Zhu,2 Yali Wang,1 Bo Liu,1 Xin Yang,2 Qiushi Wang,2 Juan Du,2 Yu Ma,2 Li Lin,2 Ping Fu,2 Hualiang Xiao,2 Qiao-Nan Guo1 1Department of Pathology, Second Affiliated Hospital, Amy Medical University (Third Military Medical University), Chongqing 400037, People’s Republic of China; 2Department of Pathology, Daping Hospital, Amy Medical University (Third Military Medical University), Chongqing 400042, People’s Republic of ChinaCorrespondence: Qiao-Nan Guo; Hualiang Xiao Email qiaonan85@263.net; dpbl_xhl@126.comPurpose: To observe the clinicopathological, immunohistochemical, and molecular genetic features of epithelioid glioblastoma (E-GBM), and identify tumor-associated prognostic factors.Patients and Methods: The clinical and radiological data of fifteen cases of E-GBM were collected, and their pathological, immunohistochemical, and molecular features were examined. A 1p/19q analysis via FISH, MGMT promoter methylation by MS-PCR, and IDH1 and BRAF V600E mutation analysis by HRM-PCR were performed. The level of EZH2 expression was valuated by immunohistochemistry in 15 E-GBM cases, and the prognostic factors were analyzed in E-GBM patients. Fifteen non-E-GBM cases were used as a control.Results: The fifteen cases of E-GBM included twelve males and three females, with fourteen cases supratentorially located. Headache was the main symptom. Microscopy revealed that the tumors were composed of epithelioid cells and some rhabdoid cells. The epithelioid and rhabdoid cells displayed focal discohesion, scant intervening neuropil, a distinct cell membrane, eosinophilic cytoplasm, and a laterally positioned nucleus. Most tumors showed high mitosis, zonal necrosis, and microvascular hyperplasia. Immunohistochemical findings included epithelioid cells positive for GFAP, vimentin, nestin, S-100, and INI-1. The molecular findings included no deletions of 1p/19q, EGFR amplifications, or IDH1 mutations in any case, a methylated MGMT promoter in 46.7% (7/15) cases, and a BRAFV600E mutation in 46.7% (7/15) cases. EZH2 overexpression occurred in 60.0% (9/15) of E-GBM cases. E-GBM patients with OS (≤ 12 months) exhibited extensive necrosis (6/6), EZH2 overexpression (6/6), MGMT promoter unmethylation (5/6), BRAFV600E mutation (3/6), and treatment (surgery4/6). E-GBM patients with OS (> 12 months) exhibited focal or limited necrosis, low or negative EZH2 expression, MGMT promoter methylation (2/3), BRAFV600E mutation (3/3), and treatment (surgery+radiotherapy/chemo-radiotherapy, 2/3).Conclusion: E-GBM was a rare variant of glioblastoma, with histological epithelioid features and poor prognosis. Extensive necrosis, MGMT promoter unmethylation, EZH2 overexpression, and lack of adjuvant chemo-radiotherapy may indicate a poor prognosis.Keywords: central nervous system tumor, epithelioid glioblastoma, immunohistochemistry, clinicopathological features, molecular genetics, differential diagnosis
Anahtar Kelimeler : central nervous system tumor, epithelioid glioblastoma, immunohistochemistry, clinicopathological features, molecular genetics, differential diagnosis
ISSN: 1178-6930
Cilt: 13
Sayfa: 3943 - 3952
Sınıflandırma :
30
Different Characteristics of Ex-Smokers and Current Smokers with COPD: A Cross-Sectional Study in China
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
International Journal of COPD
Yazar(lar) :
Liu C , Cheng W , Zeng Y , Zhou Z , Zhao Y , Duan J , Wang R , Sun T , Li X , Xiang Z , Chen P , Lei S
Yıl :
2020
Zeng Y
Yayıncı Web Sitesi
Kaydet Alıntıla
Cong Liu,1 Wei Cheng,1 Yuqin Zeng,1 Zijing Zhou,1 Yiyang Zhao,1 Jiaxi Duan,1 Ran Wang,1 Tian Sun,1 Xin Li,2 Zhi Xiang,3 Ping Chen,1 Si Lei1 1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University; Research Unit of Respiratory Disease, Central South University; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha 410011, Hunan, People’s Republic of China; 2Department of Respiratory Diseases, Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha 410007, Hunan, People’s Republic of China; 3Department of Respiratory Diseases, The First People’s Hospital of Huaihua, Affiliated to University of South China, Huaihua 418000, Hunan, People’s Republic of ChinaCorrespondence: Ping Chen; Si Lei Email pingchen0731@csu.edu.cn; leisi0831@csu.edu.cnPurpose: Chronic obstructive pulmonary disease (COPD), usually caused by tobacco smoking, is increased in China. Smoking cessation is the first step in COPD management. Data on predictors of smoking cessation are sparse in COPD patients in China. We aim to find the differences in the clinical characteristics between ex-smokers and current smokers with COPD to determine the factors related to smoking cessation.Patients and Methods: From outpatient departments of 12 hospitals in Hunan and Guangxi provinces, a total of 4331 patients were included. Information on demographic and sociological data, lung function, and modified Medical Research Council (mMRC) dyspnea scale scores were recorded. Patients were divided into an ex-smokers group and a current smokers group based on whether they gave up smoking. A logistic regression analysis was performed to analyze the factors associated with smoking cessation.Results: Of the total, the mean age was 62.9± 8.5 years, and 47.3% were ex-smokers. Compared with the current smokers, the ex-smokers were older, and had heavier dyspnea, more severe airflow limitation, fewer pack-years, shorter smoking duration, and a higher proportion of Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups C and D. The logistic regression model showed that smoking cessation was negatively correlated with widowhood, years of smoking, and forced expiratory volume in 1 second (FEV1), but was positively correlated with age, education level, amount smoked, mMRC score, GOLD grades, and GOLD groups.Conclusion: Among patients with COPD, more than half still smoked. In the group of patients who quit smoking, many of them quit rather late in age after they had significant symptoms. Several predictors of smoking cessation were identified, indicating that ex-smokers differ substantially from continuing smokers. This should be taken into account in smoking-cessation interventions.Keywords: COPD, cross-sectional study, ex-smokers and current smokers, smoking cessation
Anahtar Kelimeler : cross-sectional study, ex-smokers and current smokers, smoking cessation
Cilt: 15
Sayfa: 1613 - 1619
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