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Effects of Selective Dorsal Rhizotomy on Ankle Joint Function in Patients With Cerebral Palsy
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Araştırma Makalesi
Open Access
Kaynak :
Aperta - TÜBİTAK Açık Arşivi
Dergi:
FRONTIERS IN PEDIATRICS
Yazar(lar) :
Kenton R Kaufman , Joline E Brandenburg , Filiz Ates
Yıl :
2020
FRONTIERS IN PEDIATRICS
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Selective dorsal rhizotomy (SDR) is a neurosurgical technique performed to reduce muscle spasticity and improve motor functions in children with cerebral palsy (CP). In long term, muscle contractures were observed even after SDR. To better understand what is contributing to contracture formation, it is necessary to assess the effects of SDR on joint stiffness. We hypothesized that ankle passive range of motion (ROM) increases and the quasi-stiffness of the ankle joint decreases after SDR in children with CP. This retrospective study included 10 children with diplegic CP (median age 6 years 2 months) who had undergone SDR and for whom gait analysis data were collected 3 months before (Pre-SDR) and 13 months after (Post-SDR) surgery. Additional to clinical measures, ankle quasi-stiffness (the slope of the ankle moment vs. ankle angle plot) was analyzed from gait data. Passive ankle ROM at 0 degrees (p < 0.0001) and 90 degrees knee angles (p < 0.0001) increased after SDR. Dynamic EMG analysis showed improved phasic gastrocnemius activity (p < 0.0001). Equinus gait was improved with the reduction of peak plantar flexion (p < 0.0001), as well as an increase in peak dorsiflexion (p = 0.006) during walking was observed. Ankle joint quasi-stiffness (Pre- and post-SDR median = 0.056 Nm/kg/degrees and 0.051 Nm/kg/degrees, and interquartile range: 0.031 Nm/kg/degrees and 0.019 Nm/kg/degrees, respectively) decreased significantly (p = 0.0017) after SDR. Moreover, even though the total time of the gait cycle did not change (p = 0.99), the time interval from maximum dorsiflexion to maximum plantar flexion (Pre- and post-SDR median = 0.125 s and 0.156 s, and interquartile range: 0.153 and 0.253 s, respectively) increased significantly (p = 0.0068) after SDR. In conclusion, the decreased ankle quasi-stiffness and the enhanced time interval in the gait cycle due to SDR indicate better motor control and joint stability. Our findings suggest that the long-term contracture formation occurring even after surgical interventions may be related to the stiffening of non-contractile structures.
DOI : 10.3389/fped.2020.00075
Sayi :8
Sınıflandırma :
2
Exploring the Clinical and Genetic Spectrum of Steroid Resistant Nephrotic Syndrome: The PodoNet Registry
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak 1:
Aperta - TÜBİTAK Açık Arşivi
Kaynak 2:
Directory of Open Access Journals (DOAJ)
Dergi:
FRONTIERS IN PEDIATRICS
Yazar(lar) :
Franz Schaefer , Beata S Lipska-Zietkiewicz , Agnes Trautmann
Yıl :
2018
FRONTIERS IN PEDIATRICS
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Kaydet Alıntıla
Background: Steroid resistant nephrotic syndrome (SRNS) is a rare condition, accounting for 10-15% of all children with idiopathic nephrotic syndrome. SRNS can be caused by genetic abnormalities or immune system dysfunction. The prognosis of SRNS varies from permanent remission to progression to end-stage kidney disease, and post-transplant recurrence is common.
DOI : 10.3389/fped.2018.00200
Sayi :6
Sınıflandırma :
3
Performance Evaluation of a New Coulometric Endpoint Method in Sweat Testing and Its Comparison With Classic Gibson&Cooke and Chloridometer Methods in Cystic Fibrosis
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
Aperta - TÜBİTAK Açık Arşivi
Dergi:
FRONTIERS IN PEDIATRICS
Yazar(lar) :
Goncagul Haklar , Fazilet Karakoc , Refika Ersu , Nilay Bas Ikizoglu , Ozgur Baykan , Tuncay Seyrekel , Bulent Karadag , Pinar Vatansever , Yasemin Gokdemir
Yıl :
2018
FRONTIERS IN PEDIATRICS
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Background: The objective of the study was to assess the diagnostic efficacy of the coulometric endpoint method and compare it with classic Gibson&Cooke and chloridometer methods.
DOI : 10.3389/fped.2018.00133
Sayı :6
Sınıflandırma :
4
16q24.3 Microduplication in a Patient With Developmental Delay, Intellectual Disability, Short Stature, and Nonspecific Dysmorphic Features: Case Report and Review of the Literature
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Simona Bucerzan , Simona Bucerzan , Diana Miclea , Diana Miclea , Cecilia Lazea , Cecilia Lazea , Carmen Asavoaie , Andrea Kulcsar , Paula Grigorescu-Sido
Yıl :
2020
Frontiers in Pediatrics
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We describe the case of a seven-year-old female patient who presented in our service with severe developmental delay, intellectual disability, facial dysmorphism, and femur fracture, observed in the context of very low bone mineral density. Array-based single nucleotide polymorphism (SNP array) analysis identified a 113 kb duplication involving the morbid OMIM genes: ANKRD11 (exon1), RPL13, and PGN genes. ANKRD11 deletions are frequently described in association with KBG syndrome, the duplications being less frequent (one case described before). The exome sequencing was negative for pathogenic variants or of uncertain significance in genes possibly associated with this phenotype. The patient presented subtle signs of KBG syndrome. It is known that the phenotype of KBG syndrome has a wide clinical spectrum, this syndrome being often underdiagnosed due to overlapping features with other conditions, also characterized by multiple congenital anomalies and intellectual disability. The particularity of this case is represented by the very low bone mineral density in a patient with 16q24.3 duplication. ANKRD11 haploinsufficiency is known to be associated with skeletal involvement, such as short stature, or delayed bone age. An effect on bone density has been observed only in experimental studies on mice with induced missense mutations in the ANKRD11 gene. This CNV also involved the duplication of the very conserved RPL13 gene, which could have a role for the skeletal phenotype of this patient, knowing the high level of gene expression in bone tissue and also the association with spondyloepimetaphyseal dysplasia Isidor Toutain type, in case of splicing mutations.
DOI : 10.3389/fped.2020.00390
Anahtar Kelimeler : developmental delay, short stature, 16q24.3 duplication, osteoporosis, dysmorphic features
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
5
Intermittent hypoxia in childhood: the harmful consequences versus potential benefits of therapeutic uses
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Tatiana V. Serebrovskaya , Lei eXi
Yıl :
2015
Frontiers in Pediatrics
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Intermittent hypoxia often occurs in early infancy in both preterm and term infants and especially at 36 to 44 weeks postmenstrual age. These episodes of intermittent hypoxia could result from sleep-disordered breathing or may be temporally unrelated to apnea or bradycardia events. There are numerous reports indicating adverse effects of intermittent hypoxia on development, behavior, academic achievement and cognition in children with sleep apnea syndrome. It remains uncertain the exact causative relationship between the neurocognitive and behavioral morbidities and intermittent hypoxia and/or its associated sleep fragmentation. On the other hand, well-controlled and moderate intermittent hypoxia conditioning/training has been used in sick children for treating their various forms of bronchial asthma, allergic dermatoses, autoimmune thyroiditis, cerebral palsy, and obesity. This review article provides an updated and impartial analysis on the currently available evidence in supporting either side of the seemingly contradictory scenarios. We wish to stimulate a comprehensive understanding of such a complex physiological phenomenon as intermittent hypoxia, which may be accompanied by other confounding factors (e.g. hypercapnia, polycythemia), in order to prevent or reduce its harmful consequences, while maximize its potential utility as an effective therapeutic tool in pediatric patients.
DOI : 10.3389/fped.2015.00044
Anahtar Kelimeler : adaptation, Sleep Apnea, bronchial asthma, intermittent hypoxia, Neurocognitive development, Age difference
ISSN: 2296-2360
Cilt: 3
Sınıflandırma :
6
Pet-Keeping in Relation to Asthma, Rhinitis, and Eczema Symptoms Among Adolescents in Kuwait: A Cross-Sectional Study
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Khadijah A. AlShatti , Ali H. Ziyab
Yıl :
2020
Frontiers in Pediatrics
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Background: Findings on the associations between household pet-keeping and allergic diseases, including asthma, rhinitis, and eczema, have been contradictory, with investigations reporting positive, negative, and null associations. This study sought to estimate the prevalence of pet-keeping among families in Kuwait and to assess the associations between pet-keeping and symptoms of allergic diseases among adolescents.Methods: Schoolchildren aged 11–14 years (n = 3,864) were enrolled in this cross-sectional study. The children's parents completed questionnaires regarding their child's environmental exposures, including pet-keeping in the past 12 months, and clinical history and symptoms of allergic diseases. Associations were assessed using Poisson regression with robust variance estimation, and adjusted prevalence ratios (aPRs) and their 95% confidence intervals (CIs) were estimated.Results: Pet-keeping in the past 12 months was reported by 42.8% of the participating families. Birds, cats, rabbits, fish, and dogs were kept by 28.3, 13.2, 7.8, 3.9, and 3.1% of all households, respectively. Current cat ownership was significantly associated with current wheezing (aPR 1.29, 95% CI 1.05–1.58), current rhinitis symptoms (aPR 1.18, 95% CI 1.02–1.36), and ever doctor-diagnosed eczema (aPR 1.25, 95% CI 1.03–1.50). Current rabbit-keeping was positively associated with multiple symptoms of asthma (e.g., study-defined current asthma: aPR 1.38, 95% CI 1.04–1.82) and eczema (e.g., severe eczema: aPR 1.94, 95% CI 1.02–3.71). Similarly, current bird-keeping was associated with study-defined current rhinitis (aPR 1.19, 95% CI 1.05–1.41) and current itchy rash (aPR 1.27, 95% CI 1.10–1.46).Conclusions: Household pet-keeping is very common and diverse in Kuwait and was found to be positively associated with symptoms of allergic diseases among adolescents. The findings of associations between rabbit-keeping and symptoms of asthma and eczema add to the existing literature and further highlight the importance of considering the pet type when assessing such associations.
DOI : 10.3389/fped.2020.00331
Anahtar Kelimeler : allergy, asthma, eczema, rhinitis
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
7
Effects of Lactoferrin-Fortified Formula on Acute Gastrointestinal Symptoms in Children Aged 12–32 Months: A Randomized, Double-Blind, Placebo-Controlled Trial
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Noriko Motoki , Masaru Mizuki , Teruomi Tsukahara , Momoko Miyakawa , Shutaro Kubo , Hirotsugu Oda , Miyuki Tanaka , Koji Yamauchi , Fumiaki Abe , Tetsuo Nomiyama
Yıl :
2020
Frontiers in Pediatrics
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Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children.Design: Randomized, double-blind, placebo-controlled trial.Setting and subjects: Children aged 12–32 months in Japan.Intervention: Intake of placebo or LF (48 mg/day)-fortified formula for 13 weeks.Primary endpoint: Prevalence of acute gastrointestinal and respiratory symptom.Results: One hundred nine participants were randomized. Eight participants were lost to follow-up, withdrew consent, or were deemed inappropriate for the trial, with 101 participants receiving complete analyses (placebo group, n = 48; LF group, n = 53).Outcomes: The prevalence of acute gastrointestinal symptoms was significantly less in the LF group (22/53 [41.5%]) than in the placebo group (30/48 [62.5%], p = 0.046). The total number of days having acute respiratory symptoms was significantly lower in the LF group (9.0) than in the placebo group (15.0, p = 0.030).Harms: The rate of adverse events was similar between the groups. No adverse drug reactions were found.Conclusions: LF intake decreased the prevalence of acute gastrointestinal symptoms in children aged 12–32 months.
DOI : 10.3389/fped.2020.00233
Anahtar Kelimeler : lactoferrin, infectious disease, diarrhea, growing-up formula, children
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
8
A Novel Homozygous Frameshift Variant in DYM Causing Dyggve-Melchior-Clausen Syndrome in Pakistani Patients
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Nagwa E. A. Gaboon , Asia Parveen , Asia Parveen , Khaled A. Ahmad , Taghreed Shuaib , Jumana Y. Al-Aama , Jumana Y. Al-Aama , Lereen Abdelwehab , Amina Arif , Naveed Wasif , Naveed Wasif , Naveed Wasif
Yıl :
2020
Frontiers in Pediatrics
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Background: Dyggve-Melchior-Clausen syndrome (DMC) is a skeletal dysplasia with associated defects of brain development and intelligence. The truncating pathogenic variants in DYM are the most frequent cause of DMC. Smith-McCort (SMC), another skeletal dysplasia, is also caused by non-synonymous DYM variants.Methods and Results: In the current study, we examined a Pakistani consanguineous family with three affected members. Clinical features like spondyloepimetaphyseal dysplasia, indicative of characteristic skeletal abnormalities, and intellectual disability were observed. Our male patients had microcephaly and coarse facial features while the female patient did not represent microcephaly or abnormal facies, which are significant features of DMC patients. Sanger sequencing identified a novel homozygous frameshift insertion (c.95_96insT, p.W33Lfs*14) in DYM, which likely leads to nonsense-mediated decay (NMD).Conclusion: The novel frameshift change verifies the fact that pathogenic variants in DYM are the most frequent cause of DMC.
DOI : 10.3389/fped.2020.00383
Anahtar Kelimeler : Dyggve-Melchior-Clausen syndrome, Smith-McCort dysplasia, consanguineous, Sanger sequencing
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
9
The Shisong Cardiac Center in Cameroon: An Example of a Long-Term Collaboration/Cooperation Toward Autonomy
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Alessandro Giamberti , Alessandro Giamberti , Gianfranco Butera , Gianfranco Butera , Charles MVE Mvondo , Silvia Cirri , Alessandro Varrica , Nadia Moussaidi , Giuseppe Isgrò , Jean Claude Ambassa , Cabral Tantchou , Giovanni Giamberti , Alessandro Frigiola , Alessandro Frigiola
Yıl :
2018
Frontiers in Pediatrics
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Congenital heart diseases (CHD) are present in nearly 1% of live births; according to WHO, there are 1. 5 million newborns affected by CHD per year and more than 4 million children waiting for cardiac surgery treatment worldwide. The majority of these children (~90%) could be treated, saved and subsequently have a good quality of life but unfortunately, in developing countries with a suboptimal care or no access to care, they are destined to die. Cameroon, one of the 40 poorest countries in the world, is a typical example of this dramatic scenario and this is why we started a collaboration project with a local religious partner (Tertiary Sisters of Saint Francis) in 2001 with the aim of establishing the first cardiac surgery center in this country. There are various well-known organizational models to start a cooperation project in pediatric cardiac surgery in a developing country. In our case, the project included a long-term collaboration with a stable local partner, a big financial investment and a long period of development (10 years or more). It is probably the most difficult model but it is the only one with the greatest guarantee of success in terms of sustainability and autonomy. The aim of this study is to analyze the constructive and problematic aspects of the 17-year collaboration in this project, and to assess possible solutions regarding its critical issues. Although much has been done during this 17-year we are aware that there is still a lot that needs to be done.
DOI : 10.3389/fped.2018.00188
Anahtar Kelimeler : health, cooperation, cardiac surgery, congenital heart disease, collaboration project
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
10
Blood Biomarkers of Sensitization and Asthma
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Hans-Joachim Sonntag , Sarah Filippi , Sarah Filippi , Spyros Pipis , Spyros Pipis , Adnan Custovic
Yıl :
2019
Frontiers in Pediatrics
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Biomarkers are essential to determine different phenotypes of childhood asthma, and for the prediction of response to treatments. In young preschool children with asthma, aeroallergen sensitization, and blood eosinophil count of 300/μL or greater may identify those who can benefit from the daily use of inhaled corticosteroids (ICS). We propose that every preschool child who is considered for ICS treatment should have these two features measured as a minimum before a decision is made on the commencement of long-term preventive treatment. In practice, IgE-mediated sensitization should be considered as a quantifiable variable, i.e., we should use the titer of sIgE antibodies or the size of skin prick test response. A number of other blood biomarkers may prove useful (e.g., allergen-specific IgG/IgE antibody ratios amongst sensitized individuals, component-resolved diagnostics which measures sIgE response to a large number of allergenic molecules, assessment of immune responses to viruses, level of serum CC16, etc.), but it remains unclear whether these can be translated into clinically useful tests. Going forward, a more integrated approach which takes into account multiple domains of asthma, from the pattern of symptoms and blood biomarkers to genetic risk and lung function measures, is needed if we are to move toward a stratified approach to asthma management.
DOI : 10.3389/fped.2019.00251
Anahtar Kelimeler : asthma, biomarkers, data driven analysis, cohorts, eosinophils
ISSN: 2296-2360
Cilt: 7
Sınıflandırma :
11
Development of a Rapid Salivary Proteomic Platform for Oral Feeding Readiness in the Preterm Newborn
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Prarthana Khanna , Jill L. Maron , David R. Walt
Yıl :
2017
Frontiers in Pediatrics
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Oral feeding competency is a major determinant of length of stay in the neonatal intensive care unit. An infant must be able to consistently demonstrate the ability to take all required enteral nutrition by mouth before discharge home. Most infants born prematurely (<37 weeks) will require days, if not weeks, to master this oral feeding competency skill. Inappropriately timed feeding attempts can lead to acute and long-term morbidities, prolonged hospitalizations, and increased health-care costs. Previously, a panel of five genes involved in essential developmental pathways including sensory integration (nephronophthisis 4, Plexin A1), hunger signaling [neuropeptide Y2 receptor (NPY2R), adenosine-monophosphate-activated protein kinase (AMPK)], and facial development (wingless-type MMTV integration site family, member 3) required for oral feeding success were identified in neonatal saliva. This study aimed to translate these five transcriptomic biomarkers into a rapid proteomic platform to provide objective, real-time assessment of oral feeding skills, to better inform care, and to improve neonatal outcomes. Total protein was extracted from saliva of 10 feeding-successful and 10 feeding-unsuccessful infants matched for age, sex, and post-conceptional age. Development of immunoassays was attempted for five oral feeding biomarkers and two reference biomarkers (GAPDH and YWHAZ) to normalize for starting protein concentrations. Normalized protein concentrations were correlated to both feeding status at time of sample collection and previously described gene expression profiles. Only the reference proteins and those involved in hunger signaling were detected in neonatal saliva at measurable levels. Expression patterns for NPY2R and AMPK correlated with the gene expression patterns previously seen between successful and unsuccessful feeders and predicted feeding outcome. Salivary proteins associated with hunger signaling are readily quantifiable in neonatal saliva and may be utilized to assess oral feeding readiness in the newborn. This study lays the foundation for the development of an informative, rapid, proteomic platform to assess neonatal oral feeding maturation.
DOI : 10.3389/fped.2017.00268
Anahtar Kelimeler : protein, biomarker, saliva, adenosine-monophosphate-activated protein kinase, neuropeptide Y2 receptor
ISSN: 2296-2360
Cilt: 5
12
Detection and Potential Utility of C-Reactive Protein (CRP) in Saliva of Neonates
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Anjali eIyengar , Jessica K. Paulus , Jessica K. Paulus , Daniel J. Gerlanc , Jill L Maron , Jill L Maron
Yıl :
2014
Frontiers in Pediatrics
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Objective: We aimed to detect CRP in neonatal saliva and evaluate its diagnostic utility. Study Design: Salivary and serum samples (n=89) were collected from 40 neonates. Salivary CRP levels were determined using an enzyme-linked immunosorbent assay (ELISA); serum CRP was measured per hospital protocol. Correlation coefficients with 95% confidence intervals and robust linear regression measured association while receiver-operator characteristic (ROC) curves described the accuracy of salivary CRP in discriminating abnormal serum CRP thresholds of ≥ 10 mg/L and 5 mg/L. Corresponding sensitivities and specificities were calculated for these salivary cutpoints. Results: The Area Under the Curve (AUC) for salivary CRP in predicting serum CRP levels of ≥ 10 mg/L and 5mg/L were 0.81 and 0.76, respectively. The corresponding sensitivity and specificity for raw salivary CRP to discriminate a serum CRP of ≥ 5 mg/L was 0.54 and 0.95, respectively. The corresponding sensitivity and specificity for raw salivary CRP to discriminate a serum CRP of ≥ 10 mg/L was 0.64 and 0.94, respectively. A statistically significant correlation was observed between serum and salivary CRP (r = 0.62, p < 0.001). Conclusions: CRP is detectable in neonatal saliva and can predict abnormal serum CRP thresholds. Salivary CRP analysis represents a feasible screening tool for detecting abnormal serum CRP levels.
DOI : 10.3389/fped.2014.00131
Anahtar Kelimeler : Inflammation, Saliva, biomarker, C-reactive protein (CRP), neonates
ISSN: 2296-2360
Cilt: 2
13
Growth Hormone Receptor Gene Expression Increase Reflects Nutritional Status Improvement in Patients Affected by Crohn's Disease
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Sara Pagani , Elena Bozzola , Caterina Strisciuglio , Cristina Meazza , Erasmo Miele , M. Malamisura , Paola De Angelis , Mauro Bozzola
Yıl :
2018
Frontiers in Pediatrics
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Kaydet Alıntıla
Background: We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD).Methods: We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-I), and growth hormone receptor (GHR) gene expression in peripheral blood mononuclear cells of 21 patients with CD (before and after therapy) and in 27 age-sex-matched controls.Results: At diagnosis, significantly lower insulin-like growth factor-I and growth hormone binding protein levels were found in the CD group compared to the controls. Growth hormone receptor mRNA expression was lower in patients at diagnosis compared to the controls, even though the difference did not reach statistical significance, and significantly increased in patients in the following year. Insulin-like growth factor-I levels showed significant improvements 1 year after diagnosis compared to basal levels. On the contrary, growth hormone binding protein values had not significantly changed after 1 year of therapy.Conclusion: Our study raises the hypothesis of another mechanism through which cytokines interact with the growth hormone/insulin-like growth factor-I (GH/IGF-I) axis.
DOI : 10.3389/fped.2018.00338
Anahtar Kelimeler : IGF-I, short stature, inflammation, growth hormone receptor, Crohn's disease
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
14
NO better way to protect the heart during ischemia-reperfusion: to be in the right place at the right time.
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Charlotte eFarah , Cyril eReboul
Yıl :
2015
Frontiers in Pediatrics
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Kaydet Alıntıla
DOI : 10.3389/fped.2015.00006
Anahtar Kelimeler : Nitric Oxide, nitrite, S-nitrosylation, ischemia reperfusion, pre-conditionning, post-conditionning
ISSN: 2296-2360
Cilt: 3
Sınıflandırma :
15
Effects of Nasal Continuous Positive Airway Pressure and High-Flow Nasal Cannula on Sucking, Swallowing, and Breathing during Bottle-Feeding in Lambs
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Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Nathalie Samson , Nathalie Samson , Charlène Nadeau , Charlène Nadeau , Laurence Vincent , Laurence Vincent , Danny Cantin , Danny Cantin , Jean-Paul Praud , Jean-Paul Praud
Yıl :
2018
Frontiers in Pediatrics
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Kaydet Alıntıla
The use of prolonged respiratory support under the form of high-flow nasal cannula (HFNC) or nasal continuous positive airway pressure (nCPAP) is frequent in newborn infants. Introduction of oral feeding under such nasal respiratory support is, however, highly controversial among neonatologists, due to the fear that it could disrupt sucking, swallowing, and breathing coordination and in turn induce cardiorespiratory events. The recent observation of tracheal aspirations during bottle-feeding in preterm infants under nCPAP justifies the use of animal models to perform more comprehensive physiological studies on the subject, in order to gain further insights for clinical studies. The objective of this study was to assess and compare the impact of HFNC and nCPAP on bottle-feeding in newborn lambs, in terms of bottle-feeding efficiency and safety as well as sucking–swallowing–breathing coordination. Eight full-term lambs were instrumented to record sucking, swallowing, and respiration as well as electrocardiogram and oxygenation. Lambs were bottle-fed in a standardized manner during three randomly ordered conditions, namely nCPAP 6 cmH2O, HFNC 7 L/min, and no respiratory support. Results revealed that nCPAP decreased feeding duration [25 vs. 31 s (control) vs. 57 s (HFNC), p = 0.03] and increased the rate of milk transfer [2.4 vs. 1.9 mL/s (control) vs.1.1 mL/s (HFNC), p = 0.03]. No other indices of bottle-feeding safety or sucking–swallowing–breathing coordination were significantly altered by HFNC or nCPAP. In conclusion, our results obtained in full-term newborn lambs suggest that: (i) nCPAP 6 cmH2O, but not HFNC 7 L/min, increases bottle-feeding efficiency; (ii) bottle-feeding is safe under nCPAP 6 cmH2O and HFNC 7 L/min, with no significant alteration in sucking–swallowing–breathing coordination. The present informative and reassuring data in full-term healthy lambs must be complemented by similar studies in preterm lambs, including mild-to-moderate respiratory distress alleviated by respiratory support in order to mimic preterm infants with bronchopulmonary dysplasia and pave the way for clinical studies.
DOI : 10.3389/fped.2017.00296
Anahtar Kelimeler : suckingu2013swallowingu2013breathing coordination, nasal continuous positive airway pressure, high-flow nasal cannula, bottle-feeding efficiency and safety, full-term lambs
ISSN: 2296-2360
Cilt: 5
Sınıflandırma :
16
Long-Term Outcome of Transcatheter Device Closure of Perimembranous Ventricular Septal Defects
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Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Krishna D. Mandal , Danyan Su , Yusheng Pang
Yıl :
2018
Frontiers in Pediatrics
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Background: Ventricular septal defect is a common congenital heart defect. Transcatheter closure of perimembranous ventricular septal defect (pmVSD) is an effective method alternative to surgical closure. The aim of the study is to evaluate the procedural result, early and long-term follow-up outcome of transcatheter closure of pmVSD.Methods: From January 2005 to December 2016, we retrospectively identified the patients who underwent transcatheter device closure of pmVSD. All patients underwent transthoracic echocardiography (TTE) and electrocardiogram (ECG) before and after the procedure. Follow-up evaluation was done at 1, 3, 6, 12 months and yearly thereafter with TTE and ECG.Results: Total 186 patients (95 male, 91 female) had catheter-based intervention of pmVSD. The mean age at the time of procedure was 5.4 ± 2.8 years (range 2~14 years) and the mean weight was 18.1 ± 6.7 kg (range 10.5~43 kg). The mean size of the implanted device was 8.4 ± 2.1 mm (range 5~16 mm). The device was successfully implanted in 180 patients (96.8%). Immediate post-procedural echocardiography showed complete occlusion in all but one patient had trivial residual shunt. Total early adverse events occurred in 16 patients (8.9%). Only in two patients it was significant, complete AVB occurred in a 9 years old boy, managed with temporary pacemaker and one patient had complete left bundle branch block, recovered fully after steroid therapy. During a median follow-up period of 18.4 months (range 6~120 months), no serious adverse events and complete AVB were encountered.Conclusion: In our experience, The incidence of serious adverse event is low and no late onset of complete AVB with excellent success rate and follow-up results, confirming the transcatheter closure of pmVSD is a valuable alternative to surgical closure in selected patients.
DOI : 10.3389/fped.2018.00128
Anahtar Kelimeler : cardiac catheterization, congenital heart defect, device closure, outcomes, ventricular septal defect
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
17
Simulation-Based Summative Assessment of Neonatal Resuscitation Providers Using the RETAIN Serious Board Game—A Pilot Study
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Simran K. Ghoman , Simran K. Ghoman , Maria Cutumisu , Maria Cutumisu , Maria Cutumisu , Georg M. Schmölzer , Georg M. Schmölzer
Yıl :
2020
Frontiers in Pediatrics
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Background: Each year, 13–26 million newborn babies require help to breathe at birth. Healthcare professionals (HCPs) who provide neonatal resuscitative care must be frequently evaluated to maintain and improve the quality of healthcare delivered. While simulation-based competence assessment is preferred, resource constraints hinder uptake. We aimed to examine if the RETAIN simulation-based boardgame can be used to assess HCPs' neonatal resuscitation knowledge.Method: Twenty neonatal HCPs (19 females) from the Royal Alexandra Hospital (Edmonton, Canada) were recruited. First, they completed an open-answer written test of one neonatal resuscitation scenario. Then, they completed one neonatal resuscitation scenario of difficulty comparable to that of the open-answer written test, but this time using the RETAIN board game. In the RETAIN board game (https://playretain.com, RETAIN Labs Medical Inc, Edmonton, Canada), players perform simulated neonatal resuscitation scenarios based on real-life cases, using action cards, and equipment pieces. Sessions were video-recorded and scored using Neonatal Resuscitation Program 2015 guidelines. Data are reported as mean (standard deviation) for normally distributed continuous variables, and as median (interquartile range) for non-normal continuous variables.Results: Participants consisted of the following HCPs: 8 nurses, 4 respiratory therapists, 4 nurse practitioners, and 4 neonatal fellows with median (IQR) 10.5(3–17) years of clinical experience. Overall mean (SD) Open-answer test and Game Performance was 8.6(2.1) out of 16 possible points (53%) and 29(3.2) out of 40 possible points (74%), respectively. Out of the 10 actions shared between the open-answer test and game scenario, performance on the open-answer test was mean (SD) 7.2(1.3) (72%) and game performance was mean (SD) 8.8(1.4) (88%) (V = 17, p < 0.01).Conclusion: RETAIN may provide an enjoyable and standardized alternative toward summative assessment of neonatal resuscitation providers. RETAIN may be used to improve more frequent and ubiquitous uptake of simulation-based competence assessment in healthcare settings.
DOI : 10.3389/fped.2020.00014
Anahtar Kelimeler : infants, newborn, neonatal resuscitation, simulation based education, serious game, summative assessment
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
18
Can Getting Enough Vitamin D during Pregnancy Reduce the Risk of Getting Asthma in Childhood?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Anna Papadopoulou , Evangelia Bountouvi , Konstantinos Douros
Yıl :
2017
Frontiers in Pediatrics
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The worldwide increase in asthma prevalence during the last decades and the re-emergence of vitamin D deficiency in many populations hinted toward an underlying association between these two conditions. Since asthma is presented with high incidence in childhood and neonatal vitamin D stores depend on maternal vitamin levels, a possible programming effect of maternal vitamin D status during gestation was suggested. Observational and longitudinal studies on this subject led to inconclusive results with glimmer of positivity. In the randomized controlled clinical trials (RCTs) that followed, increased doses of vitamin D were tested in pregnant women being at high risk of having an asthmatic child. Although, the results of RCTs showed a potential association with asthma-related phenotypes rather than asthma per se, the low toxicity of vitamin D supplements make it tempting to speculate that pregnant women at a high risk of obtaining a child with asthma may be benefited, especially if they are vitamin D deficient.
DOI : 10.3389/fped.2017.00087
Anahtar Kelimeler : vitamin D, asthma, childhood, pregnancy outcome, vitamin D supplementation
ISSN: 2296-2360
Cilt: 5
Sınıflandırma :
19
Child Excess Weight Status, Adult Excess Weight Status, and Cardiometabolic Risk Profile
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Hui Fan , Qi Zhu , Xingyu Zhang
Yıl :
2020
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
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Background: The potential effects of excess weight status in childhood on later adult cardiometabolic risk factors have been undetermined in a Chinese population. Additionally, the potential mitigation of these effects if adult weight status returns to normalcy has been unresolved. Accordingly, we aimed to assess the association of childhood excess weight status and its long-term change with adult cardiometabolic risk factors.Methods: A cohort study from the China Health and Nutrition Survey 1991–2009 consisted of 541 participants who were measured in childhood (≥6 and <18 years) and underwent laboratory assessment in adulthood (≥18 years). In childhood, the participants were classified into four groups as age-sex-specific body mass index (BMI) z-score quartiles. The adult cardiometabolic risk factors included overweight and obesity, hypertension, high total cholesterol, high triglyceride, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, and high hemoglobin A1c.Results: The prevalence was 61.0, 36.2, and 19.0% for ≥1, 2, and 3 cardiometabolic risk factors, respectively, with a mean 14.9-year follow-up. There was a significant trend in the progression of the number of adult cardiometabolic risk factors across childhood BMI quartiles (P < 0.001). Additionally, participants with childhood BMI z-scores ≥ 75th percentile and adult BMI z-scores < 75th percentile did not have increased cardiometabolic risks compared with those with both childhood and adulthood BMI z-scores < 75th percentile.Conclusions: Our findings revealed that child excess weight status increased adult cardiometabolic risks. However, the effects of excess weight status in childhood on adult cardiometabolic risk factors were mitigated if adult weight status returned to normalcy.
DOI : 10.3389/fped.2020.00301
Anahtar Kelimeler : weight status, cardiometabolic risk factors, childhood, adulthood, cohort
ISSN: 2296-2360
Cilt: 8
20
Minimal Change in Cardiac Index With Increasing PEEP in Pediatric Acute Respiratory Distress Syndrome
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Manpreet K. Virk , Justin C. Hotz , Wendy Wong , Robinder G. Khemani , Christopher J. L. Newth , Patrick A. Ross
Yıl :
2019
Frontiers in Pediatrics
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Kaydet Alıntıla
Objective: To determine if increasing positive end expiratory pressure (PEEP) leads to a change in cardiac index in children with Pediatric Acute Respiratory Distress Syndrome ranging from mild to severe.Design: Prospective interventional study.Setting: Multidisciplinary Pediatric Intensive Care Unit in a University teaching hospital.Patients: Fifteen intubated children (5 females, 10 males) with a median age of 72 months (IQR 11, 132) and a median weight of 19.3 kg (IQR 7.5, 53.6) with a severity of Pediatric Acute Respiratory Distress Syndrome that ranged from mild to severe with a median lung injury score of 2.3 (IQR 2.0, 2.7).Measurements: Cardiac index (CI) and stroke volume (SV) were measured on baseline ventilator settings and subsequently with a PEEP 4 cmH2O higher than baseline. Change in CI and SV from baseline values was evaluated using Wilcoxon signed rank test.Results: A total of 19 paired measurements obtained. The median baseline PEEP was 8 cmH2O (IQR 8, 10) Range 6–14 cmH2O. There was no significant change in cardiac index or stroke volume with change in PEEP. Baseline median CI 4.4 L/min/m2 (IQR 3.4, 4.8) and PEEP 4 higher median CI of 4.3 L/min/m2 (IQR 3.6, 4.8), p = 0.65. Baseline median SV 26 ml (IQR 13, 44) and at PEEP 4 higher median SV 34 ml (IQR 12, 44) p = 0.63.Conclusion: There is no significant change in cardiac index or stroke volume with increasing PEEP by 4 cmH2O in a population of children with mild to severe PARDS.Clinical Trial Registration: The study is registered on Clinical trails.gov under the Identifier: NCT02354365.
DOI : 10.3389/fped.2019.00009
Anahtar Kelimeler : positive end-expiratory pressure, acute respiratory distress syndrome, mechanical ventilation, cardiac index, stroke volume
ISSN: 2296-2360
Cilt: 7
Sınıflandırma :
21
Celiac Disease: A Review of Current Concepts in Pathogenesis, Prevention, and Novel Therapies
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Jason A. Tye-Din , Jason A. Tye-Din , Jason A. Tye-Din , Jason A. Tye-Din , Heather J. Galipeau , Daniel Agardh , Daniel Agardh
Yıl :
2018
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Our understanding of celiac disease and how it develops has evolved significantly over the last half century. Although traditionally viewed as a pediatric illness characterized by malabsorption, it is now better seen as an immune illness with systemic manifestations affecting all ages. Population studies reveal this global disease is common and, in many countries, increasing in prevalence. These studies underscore the importance of specific HLA susceptibility genes and gluten consumption in disease development and suggest that other genetic and environmental factors could also play a role. The emerging data on viral and bacterial microbe-host interactions and their alterations in celiac disease provides a plausible mechanism linking environmental risk and disease development. Although the inflammatory lesion of celiac disease is complex, the strong HLA association highlights a central role for pathogenic T cells responding to select gluten peptides that have now been defined for the most common genetic form of celiac disease. What remains less understood is how loss of tolerance to gluten occurs. New insights into celiac disease are now providing opportunities to intervene in its development, course, diagnosis, and treatment.
DOI : 10.3389/fped.2018.00350
Anahtar Kelimeler : celiac disease, gluten, T cells, microbiome, pathogenesis
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
22
Factors Associated With Successful MRI Scanning in Unsedated Young Children
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Camilia Thieba , Camilia Thieba , Ashleigh Frayne , Ashleigh Frayne , Matthew Walton , Alyssa Mah , Alina Benischek , Deborah Dewey , Deborah Dewey , Deborah Dewey , Catherine Lebel , Catherine Lebel , Catherine Lebel , Catherine Lebel
Yıl :
2018
Frontiers in Pediatrics
Yayıncı Web Sitesi
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Kaydet Alıntıla
Introduction: Young children are often unable to remain still for magnetic resonance imaging (MRI), leading to unusable images. Various preparation methods may increase success, though it is unclear which factors best predict success. Here, in a retrospective sample, we describe factors associated with successful scanning in unsedated young children. We hypothesized that the mock scanner training and fewer behavior problems would result in higher success rates.Methods: We recruited 134 children aged 2.0–5.0 years for an MRI study. We compared success between children whose parents opted for mock scanner training (n = 20) or not (n = 114), and evaluated demographic and cognitive factors that predicted success.Results: Ninety-seven children (72%) completed at least one MRI sequence successfully on their first try; 64 children (48%) provided high-quality data for all 3 structural imaging sequences. Cognitive scores were higher in successful than unsuccessful children. Children who received mock scanner training were no more likely to be successful than children without, though they had slightly higher scores on T1 image quality.Conclusions: Our data shows that scanning with minimial preparation is possible in young children, and suggests limited advantages of mock scanner preparation for healthy young children.Cognitive ability may predict success.
DOI : 10.3389/fped.2018.00146
Anahtar Kelimeler : magnetic resonance imaging, mock scanner, sedation, anesthesia, children, neuroimaging
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
23
Monitoring Circulation During Transition in Extreme Low Gestational Age Newborns: What’s on the Horizon?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
David Van Laere , David Van Laere , Michiel Voeten , Michiel Voeten , John M. Ou2019 Toole , Eugene Dempsey
Yıl :
2018
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Echocardiography and near-infrared spectroscopy have significantly changed our view on hemodynamic transition of the extreme preterm infant. Instead of focusing on maintaining an arbitrary target value of blood pressure, we aim for circulatory well-being by a comprehensive holistic assessment of markers of cardiovascular instability. Most of these clinical and biochemical indices are influenced by transition itself and remain poor discriminators to identify patients with a potential need for therapeutic intervention. At the same time, the evolution in data capturing and storage has led to a change in our approach to monitor vital parameters. Continuous trend monitoring has become more and more relevant. By using signal extraction methods, changes in trends over time can be quantified. In this review, we will discuss the impact of these innovations on the current monitoring practices and explore some of the potential benefits these techniques may have in improving real-time detection of extreme low birth weight infants at risk for morbidity related to impaired hemodynamic transition.
DOI : 10.3389/fped.2018.00074
Anahtar Kelimeler : hemodynamic, circulation, preterm, signal analysis, monitoring
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
24
Pre-clinical evaluation of rHDL encapsulated retinoids for the treatment of Neuroblastoma
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Nirupama eSabnis , Suraj ePratap , Paul eBowman , Irina eAkopova , Andras G Lacko
Yıl :
2013
Frontiers in Pediatrics
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Kaydet Alıntıla
Despite major advances in pediatric cancer research, there has been only modest progress in the survival of children with high risk neuroblastoma (HRNB). The long term survival rates of HRNB in the United States are still only 30-50%. Due to resistance that often develops during therapy, development of new effective strategies is essential to improve the survival and overcome the tendency of HRNB patients to relapse subsequent to initial treatment. Current chemotherapy regimens also have a serious limitation due to off target toxicity. In the present work, we evaluated the potential application of reconstituted high density lipoprotein (rHDL) containing fenretinide (FR) nanoparticles as a novel approach to current neuroblastoma therapeutics. The characterization and stability studies of rHDL-FR nanoparticles showed small size (<40nm) and high encapsulation efficiency. The cytotoxicity studies of free FR vs. rHDL/ FR towards the neuroblastoma cell lines SK-N-SH and SMS-KCNR showed 2.8 and 2 fold lower IC50 values for the rHDL encapsulated FR vs. free FR. More importantly, the IC50 value for retinal pigment epithelial cells (ARPE-19), a recipient of off target toxicity during FR therapy, was over 40 times higher for the rHDL/ FR as compared to that of free FR. The overall improvement in in vitro selective therapeutic efficiency was thus about 100 fold upon encapsulation of the drug into the rHDL nanoparticles. These studies support the potential value of this novel drug delivery platform for treating pediatric cancers in general, and neuroblastoma in particular
DOI : 10.3389/fped.2013.00006
Anahtar Kelimeler : Nanoparticles, Neuroblastoma, Drug delivery, Fenretinide · All-trans Retinoic acid (ATRA)
ISSN: 2296-2360
Cilt: 1
25
Cellular Therapies in Chronic Granulomatous Disease
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Tayfun Güngör , Robert Chiesa
Yıl :
2020
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Allogeneic hematopoietic stem cell transplantation (HSCT) has become the main curative treatment in patients with chronic granulomatous disease (CGD). CGD is caused by inherited defects of the phagolysomal NADPH-oxidase, leading to a lifelong propensity for invasive infections and granulomatous inflammation. After successful allogeneic HSCT, chronic infections and inflammation resolve and quality-of-life improves. Favorable long-term outcome after HSCT is dependent on the prevention of primary and secondary graft failure (GF), including falling myeloid donor chimerism (DC) below 10 %, and chronic graft-vs.-host-disease (cGVHD). The risk of GF and GvHD increases with the use of HLA-incompatible donors and this may outweigh the benefits of HSCT, mainly in patients with severe co-morbidities and in asymptomatic patients with residual NADPH-oxidase function. Seventeen scientific papers have reported on a total of 386 CGD-patients treated by HSCT with HLA-matched family/sibling (MFD/MSD), 9/10-/10/10-matched-unrelated volunteer (MUD) and cord blood donors. The median OS/EFS-rate of these 17 studies was 91 and 82%, respectively. The median rates of GF, cGVHD and de-novo autoimmune diseases were 14, 10, and 12%, respectively. Results after MFD/MSD and 10/10-MUD-transplants were rather similar, but outcome in adults with significant co-morbidities and after transplants with 9/10 HLA-MUD were less successful, mainly due to increased GF and chronic GVHD. Transplantation protocols using T-cell depleted haploidentical donors with post-transplant cyclophosphamide or TCR-alpha/beta depletion have recently reported promising results. Autologous gene-therapy after lentiviral transduction of HSC achieved OS/EFS-rates of 78/67%, respectively. Careful retrospective and prospective studies are mandatory to ascertain the most effective cellular therapies in patients with CGD.
DOI : 10.3389/fped.2020.00327
Anahtar Kelimeler : chronic granulomatous disease, hematopoietic stem cell transplantation, conditioning, therapeutic drug monitoring, serotherapy
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
26
Update on Genetic Conditions Affecting the Skin and the Kidneys
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Antonia Reimer , Antonia Reimer , Yinghong He , Cristina Has
Yıl :
2018
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Genetic conditions affecting the skin and kidney are clinically and genetically heterogeneous, and target molecular components present in both organs. The molecular pathology involves defects of cell–matrix adhesion, metabolic or signaling pathways, as well as tumor suppressor genes. This article gives a clinically oriented overview of this group of disorders, highlighting entities which have been recently described, as well as the progress made in understanding well-known entities. The genetic bases as well as molecular cell biological mechanisms are described, with therapeutic applications.
DOI : 10.3389/fped.2018.00043
Anahtar Kelimeler : epidermolysis bullosa, mosaicism, genodermatosis, kidney, mutation, RASopathy
ISSN: 2296-2360
Cilt: 6
Sınıflandırma :
27
Hypercalcemia, an Important Puzzle Piece in Uncommon Onset Pediatric Sarcoidosis—A Case Report and a Review of the Literature
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Cristina Oana Mărginean , Lorena Elena Meliţ , Gabriel Grigorescu , Claudiu Puiac , Iunius Simu
Yıl :
2020
Frontiers in Pediatrics
Yayıncı Web Sitesi
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Kaydet Alıntıla
Sarcoidosis (SD) is a systemic granulomatous condition that is especially encountered in young adults and rarely in children, affecting predominantly the lungs and lymph nodes. We report the case of a 14-year-old teenage boy admitted to our clinic for nausea, vomiting, and weight loss. Clinical examination at the time of admission revealed malaise, pallor, and abdominal tenderness in the epigastric area at palpation. Laboratory tests revealed an elevated level of hemoglobin, mild thrombocytosis, increased erythrocyte sedimentation rate, and a mild increase in creatinine and urea levels along with hypercalcemia. An abdominal ultrasound revealed a right ectopic kidney, whereas the upper digestive endoscopy showed intense hyperemia and edema of the gastric mucosa. Thoracic computed tomography scan revealed giant hilar and mediastinal lymphadenopathy, along with multiple micronodules within the lung parenchyma and ground-glass aspect. The level of angiotensin-converting enzyme was high, parathormone was normal, and vitamin D level was low. Pathological examination of the bronchial, mediastinal, and lung biopsies established the diagnosis of SD. We administered oral corticosteroids for 2 months with outstandingly favorable outcome and no signs of recurrence 6 months after the cessation of the therapy.
DOI : 10.3389/fped.2020.00497
Anahtar Kelimeler : sarcoidosis, children, hypercalcemia, renal failure, uncommon onset
ISSN: 2296-2360
Cilt: 8
Sınıflandırma :
28
Are young people using electronic media as a way of coping with stress?
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Marie eLeiner , Beverley eArgus-Calvo , Jesus ePeinado , Liz eKeller , Dan Isbell Blunk
Yıl :
2014
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.3389/fped.2014.00127
Anahtar Kelimeler : Stress, Psychological, Technology, assessment, youth coping mechanisms, media devices
ISSN: 2296-2360
Cilt: 2
Sınıflandırma :
29
Risk Factors for Chronic Cough in Young Children: A Cohort Study
Dergi Makalesi

Dergi Makalesi
Open Access
Kaynak :
Directory of Open Access Journals (DOAJ)
Dergi:
Frontiers in Pediatrics
Yazar(lar) :
Yin To Au-Yeung , Anne B. Chang , Anne B. Chang , Anne B. Chang , Keith Grimwood , Keith Grimwood , Keith Grimwood , Yolanda Lovie-Toon , Michelle Kaus , Sheree Rablin , Dan Arnold , Jack Roberts , Sarah Parfitt , Jennie Anderson , Maree Toombs , Maree Toombs , Kerry-Ann F. O'Grady
Yıl :
2020
Frontiers in Pediatrics
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Background and Objective: Data on the predictors of chronic cough development in young children are scarce. Our primary objective was to examine the factors associated with young children developing a chronic cough, with a focus on childcare attendance.Methods: A secondary analysis of data collected in a prospective cohort study of children presenting to three emergency departments and three primary healthcare centers in southeast Queensland, Australia. Eligible children where those aged <6-years presenting with cough and without known underlying chronic lung disease other than asthma. Children were followed for 4 weeks to ascertain cough duration. The primary outcome was persistent cough at day-28. Logistic regression models were undertaken to identify independent predictors of chronic cough including sensitivity analyses that accounted for children with unknown cough status at day-28.Results: In 362 children, 95 (26.2%) were classified as having chronic cough. In models that included only children for whom cough status was known at day-28, symptom duration at enrolment, age <12 months [adjusted odds ratio (aOR) 4.5, 95% confidence interval (CI) 1.1, 18.7], gestational age (aOR 3.2, 95%CI 1.4, 7.9), underlying medical conditions (aOR 2.6, 95% CI 1.3, 5.5), a history of wheeze (aOR 2.6, 95% CI 1.4, 4.8) and childcare attendance (aOR 2.3, 95% CI 1.2, 4.4) were independent predictors of chronic cough. Amongst childcare attendees only, 64 (29.8%) had chronic cough at day-28. The strongest predictor of chronic cough amongst childcare attendees was continued attendance at childcare during their illness (aOR = 12.9, 95% CI 3.9, 43.3).Conclusion: Gestational age, underlying medical conditions, prior wheeze and childcare attendance are risk factors for chronic cough in young children. Parents/careers need to be aware of the risks associated with their child continuing to attend childcare whilst unwell and childcare centers should reinforce prevention measures in their facilities.
DOI : 10.3389/fped.2020.00444
Anahtar Kelimeler : acute respiratory illness, chronic cough, children, childcare, cohort study
ISSN: 2296-2360
Cilt: 8

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