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1
ECG signs of biatrial enlargement in a young adult
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Marco Biolato , Massimo Montalto , Alfonso Sestito , Antonella Gallo , Antonio Grieco
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2010
Internal and Emergency Medicine
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DOI : 10.1007/s11739-010-0360-2
Anahtar Kelimeler : Congenital Heart Disease, Left Ventricular Hypertrophy, Pericardial Effusion, Right Bundle Branch Block, Restrictive Cardiomyopathy
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 5
Sayfa: 441-442
2
Why and when PCI, why and when thrombolysis?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Maddalena Lettino
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2008
Internal and Emergency Medicine
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DOI : 10.1007/s11739-008-0212-5
ISSN: 1828-0447 1970-9366
Sayı: 1
Cilt: 4
Sayfa: 7-9
3
The classification of hospitalized patients with hyperglycemia and its implication on outcome: results from a prospective observational study in Internal Medicine
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Filippo Pieralli , Cristina Bazzini , Alessia Fabbri , Carlotta Casati , Andrea Crociani , Francesco Corradi , Alberto Moggi Pignone , Alessandro Morettini , Carlo Nozzoli
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2015
Internal and Emergency Medicine
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The relevance of classifying hyperglycemic hospitalized subjects (HS) as known diabetes (D), newly discovered diabetes (ND), and stress hyperglycemia (SH) is unclear. The aim of this study was to determine the prevalence, in-hospital mortality, and length of stay (LOS) of three different phenotypes of HS. Fasting glucose ≥126 mg/dL (7 mmol/L) or random blood glucose ≥200 mg/dL (11.1 mmol/L) defined HS who were categorized into three groups: D; ND (no history of diabetes and HbA1c ≥48 mmol/mol); SH (no history of diabetes and HbA1c <48 mmol/mol). The end points of the study were in-hospital mortality and LOS. Of 1447 consecutive enrolled subjects, the prevalence of HS was 28.6 % (415/1447), of these 71.6 % had D, 21.2 % SH, and 7.2 % ND, respectively. In-hospital death was 3.9 % in normoglycemic and 6.0 % in hyperglycemic subjects. Individuals with SH had an increased risk of in-hospital death (7.9 %) (HR 2.17, 95 % CI 1.18–4.9; p = 0.039), while this was not observed for D and ND patients. The mean LOS was greater in ND and SH subjects. Hyperglycemia is common, and is associated with an increased risk of in-hospital mortality and extension of hospital stay. HbA1c along with clinical history is a useful tool to identify subgroups of hyperglycemic hospitalized subjects. Individuals with SH have a longer LOS, and a double risk of in-hospital mortality. Additionally, identifying previously unknown diabetes represents a remarkable opportunity for prevention of diabetes-related acute and chronic complications.
DOI : 10.1007/s11739-015-1358-6
Anahtar Kelimeler : Hyperglycemia, Glycated hemoglobin, Diabetes mellitus, Stress hyperglycemia
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 11
Sayfa: 649-656
4
Late-onset familial mediterranean fever: single-center experience and literature review
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Okan Aydin , Bugra Han Egeli , Huri Ozdogan , Serdal Ugurlu
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2022
Internal and Emergency Medicine
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Familial Mediterranean fever (FMF) is a hereditary, autoinflammatory disease characterized by recurrent fever and serositis attacks. The disease onset occurs before 20 years of age in 90% of patients and rarely after the 4th decade. The aim of this study is to screen our FMF patient pool for patients with disease onset after age of 40 and to compare them to patients with early onset with regard to clinical and genetic features. The charts of 2020 patients registered in our FMF center in the years 2008–2017 were screened with regard to age of disease onset. Patients with disease onset after the age of 40 were considered as late-onset group (Group 1). The control group (Group 2) consisted of patients with a disease onset before the age of 20 who were randomly selected from the patient pool with twice the number of probands. Demographic, clinical and genetic data were recorded. Out of 2020 patients, the attacks of FMF had started after the fourth decade in 41 patients (2.02%), (Group 1). The male to female ratio was 1:1.7 in both groups. The delay of diagnosis was 5.6 ± 5.75 years in group 1, 10.7 ± 12.3 years in group 2. The only significant difference with regard to clinical features between two groups was the frequency of fever, which was present in 26 (63.4%) patients in group 1 and 67 (81.7%) in group 2 (p = 0.026). M694V mutation was more prevalent among early-onset group whereas exon 2 variants were more frequent in patients with late onset. The mean colchicine dose in the last 6 months was 1.38 ± 0.64 mg in group 1, and 1.61 ± 0.47 mg in group 2. FMF may start after 40 years of age in approximately 2% of the patients. Lower frequency of fever, lower daily colchicine dose and lower prevalence of exon 10 mutations point out that FMF patients with a disease onset after 40 years of age experience a milder disease compared to those with an onset before the second decade of life.
DOI : 10.1007/s11739-021-02912-8
Anahtar Kelimeler : Familial Mediterranean fever, Late onset, Early onset, MEFV mutation, Colchicine
ISSN: 1828-0447 1970-9366
5
Independent risk factors for mortality in critically ill patients with candidemia on Italian Internal Medicine Wards
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Francesco Sbrana , Emanuela Sozio , Matteo Bassetti , Andrea Ripoli , Filippo Pieralli , Anna Maria Azzini , Alessandro Morettini , Carlo Nozzoli , Maria Merelli , Sebastiano Rizzardo , Giacomo Bertolino , Davide Carrara , Claudio Scarparo , Ercole Concia , Francesco Menichetti , Carlo Tascini
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2018
Internal and Emergency Medicine
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Candida is an increasing cause of bloodstream infection and is associated with significant morbidity and mortality. The aim of our study is to analyze risk factors for short-term mortality in patients with bloodstream Candida spp. infections admitted to Internal Medicine Wards (IMWs). This was a retrospective case–control study between January 2012 and December 2014 from four University Hospitals in Italy, where patients with candidemia dying within 30 days from diagnosis were matched to control cases with candidemia who survived in the same period of time. Two-hundred and fifty cases of candidemia were registered during the 36 months of enrollment. Among these, 112 patients died (45%) within 30 days from the first blood culture’s positivity for Candida spp. At multivariate analysis, septic shock [odds ratio (95% CI) = 2.919 (1.62–5.35), p < 0.001] and concomitant chronic kidney failure [odds ratio (95% CI) = 2.296 (1.07–5.12), p = 0.036] were independent predictors of mortality. Low-dose chronic steroid therapy was protective [odds ratio (95% CI) = 0.461 (0.25–0.83), p = 0.011).
DOI : 10.1007/s11739-017-1783-9
Anahtar Kelimeler : Candidemia, Chronic kidney failure, Internal medicine wards, Septic shock, Sepsis, Steroid therapy
ISSN: 1828-0447 1970-9366
Sayı: 2
Cilt: 13
Sayfa: 199-204
6
An unusual acute coronary syndrome: undisclosed disease hidden under a confounding clinical presentation
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Davide Ermacora , Beatrice Segafredo , Gentian Denas , Seena Padayattil Jose , Vittorio Pengo
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2011
Internal and Emergency Medicine
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DOI : 10.1007/s11739-011-0573-z
Anahtar Kelimeler : Pulmonary Embolism, Aortic Aneurysm, Abdominal Aortic Aneurysm, Coronary Flow Reserve, Priapism
ISSN: 1828-0447 1970-9366
Sayı: S1
Cilt: 7
Sayfa: 29-31
7
Reviewers 2017
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2018
Internal and Emergency Medicine
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DOI : 10.1007/s11739-018-1790-5
ISSN: 1828-0447 1970-9366
Sayı: 2
Cilt: 13
Sayfa: 309-311
8
A lower impact of an acute exposure to electronic cigarette aerosols than to cigarette smoke in human organotypic buccal and small airway cultures was demonstrated using systems toxicology assessment
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Anita R. Iskandar , Filippo Zanetti , Athanasios Kondylis , Florian Martin , Patrice Leroy , Shoaib Majeed , Sandro Steiner , Yang Xiang , Laura Ortega Torres , Keyur Trivedi , Emmanuel Guedj , Celine Merg , Stefan Frentzel , Nikolai V. Ivanov , Utkarsh Doshi , Kyeonghee Monica Lee , Willie J. McKinney , Manuel C. Peitsch , Julia Hoeng
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2019
Internal and Emergency Medicine
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In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke exposure. We conducted a series of in vitro studies to compare the biological impact of an acute exposure to aerosols of “test mix” (flavors, nicotine, and humectants), “base” (nicotine and humectants), and “carrier” (humectants) formulations using MarkTen® EC devices with the impact of exposure to smoke of 3R4F reference cigarettes, at a matching puff number, using human organotypic air–liquid interface buccal and small airway cultures. We measured the concentrations of nicotine and carbonyls deposited in the exposure chamber after each exposure experiment. The deposited carbonyl concentrations were used as representative measures to assess the reduced exposure to potentially toxic volatile substances. We followed a systems toxicology approach whereby functional biological endpoints, such as histopathology and ciliary beating frequency, were complemented by multiplex and omics assays to measure secreted inflammatory proteins and whole-genome transcriptomes, respectively. Among the endpoints analyzed, the only parameters that showed a significant response to EC exposure were secretion of proteins and whole-genome transcriptomes. Based on the multiplex and omics analyzes, the cellular responses to EC aerosol exposure were tissue type-specific; however, those alterations were much smaller than those following cigarette smoke exposure, even when the EC aerosol exposure under the testing conditions resulted in a deposited nicotine concentration approximately 200 times that in saliva of EC users.
DOI : 10.1007/s11739-019-02055-x
Anahtar Kelimeler : E-cigarettes, Organotypic cultures, Systems toxicology, Transcriptomics, Oral, Small airway
ISSN: 1828-0447 1970-9366
Sayı: 6
Cilt: 14
Sayfa: 863-883
9
CHADS2, CHA2DS2-VASc and R2CHADS2 scores predict mortality in patients with coronary artery disease
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Fang-Yang Huang , Bao-Tao Huang , Xiao-bo Pu , Yong Yang , Shi-Jian Chen , Tian-Li Xia , Yi-Yue Gui , Yong Peng , Rui-Shuang Liu , Yuanweixiang Ou , Fei Chen , Ye Zhu , Mao Chen
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2017
Internal and Emergency Medicine
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Few studies to date address the predictive ability of CHA2DS2-VASc and R2CHADS2 in CAD patients. Our aim is to investigate the prognostic performance of CHADS2, CHA2DS2-VASc and R2CHADS2 scores in patients with coronary artery disease (CAD). Angiographically obstructive CAD patients were enrolled. The prognostic performance of the three risk scores was evaluated using Cox hazards models. In addition, we compared their predictive values by calculating C statistics, net reclassification improvement (NRI) and integrated discrimination improvement (IDI). The endpoints are death from any cause and cardiovascular death. Of 3295 subjects with CAD, the mean CHADS2, CHA2DS2-VASc and R2CHADS2 scores are 1.2 ± 1.0, 2.4 ± 1.4, and 1.6 ± 1.4, respectively. The CHADS2-guided risk classification is markedly distinct from CHA2DS-2-VASc- and R2CHADS2-guided ones. Over a median follow-up of 24 months, a total of 290 (rate 4.00/100 person-year) deaths occurred, and 163 (rate 2.2/100 person-year) were attributed to cardiovascular deaths. Event rates increase by CHADS2, CHA2DS2-VASc and R2CHADS2 (P for trend <0.001). The multivariate analyses show 60, 111 and 82% higher risk of mortality per unit increase of CHADS2, CHA2DS2-VASc and R2CHADS2 scores, respectively. Comparing with CHADS2 score (c-statistic = 0.61), CHA2DS2-VASc (c-statistic 0.65, NRI 0.52 and IDI 0.06, P for all <0.05) and R2CHADS2 (c-statistic 0.66, NRI 0.43 and IDI 0.09, P for all <0.05) scores provide better discrimination and reclassification for mortality. Also, CHA2DS2-VASc and R2CHADS2 have comparable predictive ability of mortality to the GRACE score. The CHADS2, CHA2DS2-VASc and R2CHADS2 scores are simple yet robust prognostic tools in CAD patients.
DOI : 10.1007/s11739-017-1608-x
Anahtar Kelimeler : Coronary artery disease, CHADS2 score, CHA2DS2-VASc score, GRACE score, Renal dysfunction, Outcome
ISSN: 1828-0447 1970-9366
Sayı: 4
Cilt: 12
Sayfa: 479-486
10
Muscle depletion and the prediction of chemotherapy toxicity
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Maurizio Muscaritoli , Alessio Molfino , Filippo Rossi Fanelli
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2013
Internal and Emergency Medicine
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DOI : 10.1007/s11739-013-0966-2
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 8
Sayfa: 373-375
11
Building a trauma center and system in Tuscany, Italy
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Kevin M. Ban , Francesco Mannelli , Antonio Messineo , Monica Frassineti , Roger Barkin , David P. Mooney , Michael Shannon , Gian Franco Gensini
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2006
Internal and Emergency Medicine
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Growing evidence supports the premise that adult trauma centers lower the risk of death for severely injured patients. The same principles have been applied to the pediatric population and mounting research suggests that, as in the adult population, gravely injured children have better outcomes at pediatric trauma centers where personnel trained and experienced in the specific needs and unique physiology of injured children provide care. As in the United States, acute traumatic injury represents an important public healthcare concern to the Tuscan regional government whose goal is to maximize clinical outcomes within available resources. In order to address this problem, the Tuscan regional government has created a new and innovative collaboration between the Meyer Pediatric Hospital/University of Florence School of Medicine and the Children’s Hospital Boston/Harvard Medical School to build a pediatric trauma center and regional pediatric trauma referral system. This long-term international initiative will seek to develop a demonstration model for pediatric trauma care that may later be replicated elsewhere. The initial goals of the project will focus on expanding the role of the pediatricians working in the emergency department to include the acute care of medical, surgical, orthopedic and multiple trauma patients. This new configuration will closely resemble the single provider model of emergency medical care commonly utilized in the United States. During this transition period to a more broadly trained emergency physician, a multi-disciplinary trauma team will be created and pediatric trauma clinical practice guidelines will be introduced into the emergency department and inpatient care units. Systems measurements will be achieved through a comprehensive quality improvement and risk management program. Ultimately, all Tuscan regional pediatric major trauma will be consolidated at the Meyer Pediatric Hospital in Florence.
DOI : 10.1007/bf02934765
Anahtar Kelimeler : blunt trauma, disability, functional outcome, head injury, length of stay, pediatric trauma center, trauma outcome
ISSN: 1828-0447 1970-9366
Sayı: 4
Cilt: 1
Sayfa: 302-304
12
Prognostic influence of prior chronic obstructive pulmonary disease in patients admitted for the first time because of acute heart failure: reply
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Francesc Formiga , Karine Luz Londoño , David Chivite
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2018
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-018-1868-0
ISSN: 1828-0447 1970-9366
Sayı: 6
Cilt: 13
Sayfa: 973-974
13
Helicobacter pylori in immigrants: a “foreign” bacterium?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Angelo Zullo , Francesca Cristofari , Maria Consiglia Bragazzi , Cesare Hassan
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2010
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-010-0477-3
ISSN: 1828-0447 1970-9366
Sayı: 1
Cilt: 6
Sayfa: 7-8
14
Myxoedema coma precipitated by diabetic ketoacidosis and neuroleptic drugs: case report in an intensive care unit
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
C. Cappelli , B. Stanga , A. Paini , E. Gandossi , D. Cumetti , M. Castellano , M. L. Muiesan , E. Agabiti Rosei
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2007
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-007-0045-7
Anahtar Kelimeler : Hypothyroidism, Carpal Tunnel Syndrome, Polycythemia Vera, Diabetic Ketoacidosis, JAK2 Mutation
ISSN: 1828-0447 1970-9366
Sayı: 2
Cilt: 2
Sayfa: 147-149
15
Early introduction of anakinra improves acute pericarditis and prevents tamponade in Staphylococcal sepsis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Ludovico Luca Sicignano , Maria Grazia Massaro , Marinica Savino , Donato Rigante , Laura Gerardino , Raffaele Manna
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2021
Internal and Emergency Medicine
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Kaydet Alıntıla
The clinical response to anakinra observed by this patient concurrently treated with antibiotics indirectly confirms the potentially pathogenic role of IL-1 in maintaining the pericardial disease and shows how IL-1 blockade might allow avoiding the pericardiocentesis procedure. The report supports the hypothesis that anakinra is an effective and safe tool in the early treatment of acute pericarditis of presumed bacterial origin nonresponding to targeted antibiotic therapy.
DOI : 10.1007/s11739-020-02627-2
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 16
Sayfa: 1391-1394
16
Putative invasive pulmonary aspergillosis in apparently immunocompetent patients within medical wards and intensive care units
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Babatunde Edun , Mark Alan Tidswell
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2021
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-021-02757-1
ISSN: 1828-0447 1970-9366
Sayı: 6
Cilt: 16
Sayfa: 1429-1431
17
Coronary spasm provocation with cold pressor test
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Samad Ghaffari , Leili Pourafkari
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2010
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-010-0386-5
Anahtar Kelimeler : Clopidogrel, Diltiazem, Ergot Alkaloid, Cold Pressor Test, Normal Coronary Artery
ISSN: 1828-0447 1970-9366
Sayı: 6
Cilt: 5
Sayfa: 559-560
18
Cause-specific death in hospitalized individuals infected with SARS-CoV-2: more than just acute respiratory failure or thromboembolic events
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Marta Cobos-Siles , Pablo Cubero-Morais , Irene Arroyo-Jiménez , María Rey-Hernández , Laura Hernández-Gómez , Derly Judith Vargas-Parra , María González-Fernández , Marina Cazorla-González , Miriam Gabella-Martín , Tomás Ruíz-Albi , José Angel Berezo-García , Jesús Fernando García-Cruces-Méndez , José Pablo Miramontes-González , Luis Corral-Gudino
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2020
Internal and Emergency Medicine
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Kaydet Alıntıla
Infection with SARS-CoV-2 is becoming the leading cause of death in most countries during the 2020 pandemic. The objective of this study is to assess the association between COVID-19 and cause-specific death. The design is retrospective cohort study. We included data from inpatients diagnosed with COVID-19 between March 18 and April 21, 2020, who died during their hospital stay. Demographic, clinical and management data were collected. Causes of death were ascertained by review of medical records. The sample included 128 individuals. The median age was 84 (IQR 75–89), 57% were men. In 109 patients, the death was caused by SARS-CoV-2 infection, whereas in 19 (14.8%, 95 CI 10–22%), the infection acted only as a precipitating factor to decompensate other pathologies. This second group of patients was older (88y vs 82, p < 0.001). In age-adjusted analysis, they had a greater likelihood of heart failure (OR 3.61 95% CI 1.15–11.32), dependency in activities of daily living (OR 12.07 95% CI 1.40–103.86), frailty (OR 8.73 95% CI 1.37–55.46). The presence of X-ray infiltrates was uncommon (OR 0.07, 95% CI 0.02–0.25). A higher percentage of patient deaths from causes unrelated to COVID-19 complications occurred during the two first weeks of the pandemic. Fifteen percent of patients with COVID-19 infection died from decompensation of other pathologies and the cause of death was unrelated to COVID-19 severe complications. Most of these patients had more comorbidities and were frail and elderly. These findings can partially explain the excess mortality in older people.
DOI : 10.1007/s11739-020-02485-y
Anahtar Kelimeler : COVID-19, Cause of death, Age distribution, Risk factor, Frail elderly, Hospital mortality
ISSN: 1828-0447 1970-9366
Sayı: 8
Cilt: 15
Sayfa: 1533-1544
19
A case of pancytopenia and splenomegaly: haematological disease?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
A. Perciaccante , A. Fiorentini , J. Ora , A. Paris , P. Serra
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2007
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-007-0069-z
Anahtar Kelimeler : Visceral Leishmaniasis, Leishmaniasis, Bone Marrow Biopsy, Spontaneous Pneumothorax, Direct Agglutination Test
ISSN: 1828-0447 1970-9366
Sayı: 3
Cilt: 2
Sayfa: 238-242
20
Acknowledgement to Referees
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2011
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-011-0690-8
ISSN: 1828-0447 1970-9366
Sayı: S1
Cilt: 6
Sayfa: 139-139
21
Gender differences and survival after an out-of-hospital cardiac arrest: a systematic review and meta-analysis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Dejing Feng , Chuang Li , Xinchun Yang , Lefeng Wang
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2020
Internal and Emergency Medicine
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Kaydet Alıntıla
Patients who experience out-of-hospital cardiac arrest (OHCA) have unacceptably high mortality rates. It remains unclear whether gender has an association with survival in this regard. Hence, we aimed to investigate the association between gender and survival by conducting a systematic review and meta-analysis. The databases of PubMed, Embase, and Cochrane Database of Systematic Reviews were searched from inception to 17 March, 2020. Studies assessing the association between gender and survival to discharge or 30-day survival after OHCA were included. Two reviewers independently assessed the eligibility of the identified studies. The random-effects model was used to pool data, and the outcome was reported as odds ratios (ORs) and 95% confidence intervals, as the relative measure of association. Twenty-three eligible studies enrolling 897,805 patients were included in this systematic review. Overall, women were older and less likely to experience arrest in public places. When arrest occurred, women had less initial shockable rhythm, were less likely to be witnessed by bystanders, and were less likely provided with CPR compared with men. After admission, women underwent less coronary angiography, percutaneous coronary angiography, and targeted temperature management therapy. Eleven studies with ORs were pooled, showing a significant survival benefit in women (OR = 1.08, p < 0.05, I2 = 52.3%). In the subgroup analysis, both premenopausal women (< 50 years) (OR = 1.42, p < 0.001, I2 = 0%) and postmenopausal women (≥ 50 years) (OR = 1.07, p < 0.05, I2 = 16.4%) had higher odds of survival compared with age-matched men. Despite the unfavorable factors, the pooled results showed a significant survival benefit in women after OHCA, especially in premenopausal women.
DOI : 10.1007/s11739-020-02552-4
Anahtar Kelimeler : Gender difference, Cardiac arrest, Out-of-hospital cardiac arrest, Sudden cardiac death, Survival, Prognosis
ISSN: 1828-0447 1970-9366
Sayı: 3
Cilt: 16
Sayfa: 765-775
22
A painful diagnosis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Paolo Fraticelli , Marco Cardinali , Lorenzo Biondi , Devis Benfaremo , Massimo Mattioli , Roberta Mazzucchelli , Rodolfo Montironi , Armando Gabrielli
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2017
Internal and Emergency Medicine
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DOI : 10.1007/s11739-017-1638-4
Anahtar Kelimeler : Amyloidosis, Pregabalin, Hypertrophic Cardiomyopathy, Fabry Disease, Febuxostat
ISSN: 1828-0447 1970-9366
Sayı: 3
Cilt: 12
Sayfa: 341-347
23
Mushroom poisoning: a retrospective study concerning 11-years of admissions in a Swiss Emergency Department
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Maxime Schmutz , Pierre-Nicolas Carron , Bertrand Yersin , Lionel Trueb
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2016
Internal and Emergency Medicine
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Wild mushroom intoxication is an unusual cause of toxic ingestion in Europe. A great diversity of clinical symptoms may arise depending on the variety of wild mushrooms ingested. These initial symptoms are often non-specific, with frequent gastrointestinal symptoms, and have no direct correlation with the outcome. Therefore, management of mushroom poisoning and risk evaluation are a challenge for emergency clinicians. We retrospectively reviewed all cases of mushroom poisoning identified in the ED database spanning 11 years. Demographic and clinical data, time from consumption to symptoms, type of mushrooms, the number of patients presenting at the same time, treatment(s) provided, length of stay, discharge diagnosis, in-hospital mortality, and serious complications were evaluated. We identify 87 cases of mushroom poisoning. The most common symptoms are nausea and vomiting (71 cases, 82%), followed by diarrhea (68%), syncope (10%), abdominal pain (8%), and hallucinations (7%). Sixty-four patients (74%) exhibited early symptoms (appearance <6 h after ingestion) and 23 (26%) late symptoms (appearance >6 h after ingestion). Eleven patients (13%) required hospitalization over 24 h. Patients with late symptoms tended to have longer in-hospital lengths of stay. Only one patient had Amanita phalloides intoxication, with a favorable outcome. Thirty-eight patients (44%) were involved in cluster presentations. Mushroom poisoning is an unusual but potentially severe form of intoxication. Patients presenting with late-appearing symptoms (>6 h) are associated with a higher risk of A. phalloides intoxication, and therefore require specific investigation and management.
DOI : 10.1007/s11739-016-1585-5
Anahtar Kelimeler : Emergency medicine, Mushroom poisoning, Amanita
ISSN: 1828-0447 1970-9366
Sayı: 1
Cilt: 13
Sayfa: 59-67
24
Increasing dosages of low-molecular-weight heparin in hospitalized patients with Covid-19
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Ida Martinelli , Alessandro Ciavarella , Maria Abbattista , Stefano Aliberti , Valentina De Zan , Christian Folli , Mauro Panigada , Andrea Gori , Andrea Artoni , Anna Maria Ierardi , Gianpaolo Carrafiello , Valter Monzani , Giacomo Grasselli , Francesco Blasi , Flora Peyvandi
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2021
Internal and Emergency Medicine
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We conducted an observational cohort study in adult patients consecutively admitted for the respiratory illness Covid-19 to our hub hospital from March 9 to April 7, 2020. The high observed rate of venous thromboembolism prompted us to increase the prophylactic doses of enoxaparin from 40 mg daily up to 1 mg/kg twice daily in patients admitted to intensive care units (ICU), 0.7 mg/kg twice daily in high-intensity of care wards and 1 mg/kg daily in low-intensity of care wards. Patients on high enoxaparin doses were compared to those who received prophylaxis with the standard dosage. Efficacy endpoints were mortality, clinical deterioration, and the occurrence of venous thromboembolism, safety endpoint was the occurrence of major bleeding. Of 278 patients with Covid-19, 127 received prophylaxis with high enoxaparin doses and 151 with standard dosage. At 21 days, the incidence rate of death and clinical deterioration were lower in patients on higher doses than in those on the standard dosage (hazard ratio 0.39, 95% confidence interval 0.23–0.62), and the incidence of venous thromboembolism was also lower (hazard ratio 0.52, 95% confidence interval 0.26–1.05). Major bleeding occurred in four of 127 patients (3.1%) on the high enoxaparin dosage. In conclusion, in the cohort of patients with Covid-19 treated with high enoxaparin dosages we observed a 60% reduction of mortality and clinical deterioration and a 50% reduction of venous thromboembolism compared to standard dosage prophylaxis. However, 3% of patients on high enoxaparin dosages had non-fatal major bleeding.
DOI : 10.1007/s11739-020-02585-9
Anahtar Kelimeler : Anticoagulants, Coronavirus, Enoxaparin, Mortality, Venous thromboembolism
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 16
Sayfa: 1223-1229
25
A retrospective cohort study examining the association between body mass index and mortality in severe sepsis
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Timothy Glen Gaulton , C. Marshall MacNabb , Mark Evin Mikkelsen , Anish Kumar Agarwal , S. Cham Sante , Chirag Vinay Shah , David Foster Gaieski
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2015
Internal and Emergency Medicine
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Body mass index (BMI) is an easily calculated indicator of a patient’s body mass including muscle mass and body fat percentage and is used to classify patients as underweight or obese. This study is to determine if BMI extremes are associated with increased 28-day mortality and hospital length of stay (LOS) in emergency department (ED) patients presenting with severe sepsis. We performed a retrospective chart review at an urban, level I trauma center of adults admitted with severe sepsis between 1/2005 and 10/2007, and collected socio-demographic variables, comorbidities, initial and most severe vital signs, laboratory values, and infection sources. The primary outcome variables were mortality and LOS. We performed bivariable analysis, logistic regression and restricted cubic spline regression to determine the association between BMI, mortality, and LOS. Amongst 1,191 severe sepsis patients (median age, 57 years; male, 54.7 %; median BMI, 25.1 kg/m2), 28-day mortality was 19.9 % (95 % CI 17.8–22.4) and 60-day mortality was 24.4 % (95 % CI 21.5–26.5). Obese and morbidly obese patients were younger, less severely ill, and more likely to have soft tissue infections. There was no difference in adjusted mortality for underweight patients compared to the normal weight comparator (OR 0.74; CI 0.42–1.39; p = 0.38). The obese and morbidly obese experienced decreased mortality risk, vs. normal BMI; however, after adjustment for baseline characteristics, this was no longer significant (OR 0.66; CI 0.42–1.03; p = 0.06). There was no significant difference in LOS across BMI groups. Neither LOS nor adjusted 28-day mortality was significantly increased or decreased in underweight or obese patients with severe sepsis. Morbidly obese patients may have decreased 28-day mortality, partially due to differences in initial presentation and source of infection. Larger, prospective studies are needed to validate these findings related to BMI extremes in patients with severe sepsis.
DOI : 10.1007/s11739-015-1200-1
Anahtar Kelimeler : Sepsis, Obesity, Body mass index, Organ dysfunction, Resuscitation
ISSN: 1828-0447 1970-9366
Sayı: 4
Cilt: 10
Sayfa: 471-479
26
Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Pier Mannuccio Mannucci
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2018
Internal and Emergency Medicine
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As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration and inevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug–drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10 year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.
DOI : 10.1007/s11739-018-1941-8
Anahtar Kelimeler : Multimorbidity, Polypharmacy, Inappropriate prescription, Deprescribing, Medication reconciliation
ISSN: 1828-0447 1970-9366
Sayı: 8
Cilt: 13
Sayfa: 1191-1200
27
Postoperative dyspnea mimicking pulmonary embolism as a result of regional nerve block
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Zachary David Levy , Hannah Steinhoff
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2016
Internal and Emergency Medicine
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DOI : 10.1007/s11739-016-1400-3
Anahtar Kelimeler : Pulmonary Embolism, Nerve Block, Regional Anesthesia, Brachial Plexus Block, Diaphragmatic Paralysis
ISSN: 1828-0447 1970-9366
Sayı: 8
Cilt: 11
Sayfa: 1143-1144
28
What is behind a relapse of thrombotic thrombocytopenic purpura?
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Marco Capecchi , Andrea Artoni , Maria Domenica Cappellini , Giovanna Graziadei
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2017
Internal and Emergency Medicine
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DOI : 10.1007/s11739-017-1764-z
ISSN: 1828-0447 1970-9366
Sayı: 5
Cilt: 13
Sayfa: 709-712
29
Non-invasive ventilation in acute cardiogenic pulmonary edema: how to do it
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Tommaso Maraffi , Anna Maria Brambilla , Roberto Cosentini
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2017
Internal and Emergency Medicine
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Kaydet Alıntıla
DOI : 10.1007/s11739-017-1751-4
Anahtar Kelimeler : Acute Cardiogenic Pulmonary Edema (ACPE), ACPE Patients, Continuous Positive Airway Pressure (CPAP), CPAP Interface, Boussignac CPAP
ISSN: 1828-0447 1970-9366
Sayı: 1
Cilt: 13
Sayfa: 107-111
30
Prevalence and correlates of hyperkalemia in a renal nutrition clinic
Dergi Makalesi

Dergi Makalesi
Kaynak :
Springer Link
Dergi:
Internal and Emergency Medicine
Yazar(lar) :
Claudia Du2019Alessandro , Andrea Cumetti , Erica Pardini , Claudia Mannucci , Piera Serio , Riccardo Morganti , Adamasco Cupisti
Konu :
Emergency Medicine, Internal Medicine
Yıl :
2020
Internal and Emergency Medicine
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Kaydet Alıntıla
Hyperkalemia (HK) is a frequent complication of chronic kidney disease (CKD). Vegetable-based renal diets are considered at risk due to the high potassium (K) content. The aim of this study was to describe the prevalence and correlates of chronic hyperkalemia (HK) in CKD patients on nutritional care, and in particular, the risk of HK in patients on plant-based versus animal-based low-protein diets. We recruited adult patients affected by CKD not on dialysis, afferent to our renal nutrition clinic from November 2014 to May 2019. We evaluated a total of 870 accesses in 219 patients (172 m, 47 f, age 67 ± 13 years). HK was defined as mild when K serum level was 5.1–5.9 mEq/l, moderate when K serum level was 6.0–6.9 mEq/l, and severe HK when K serum level was ≥ 7 mEq/l. Biochemical, anthropometric data and medications were recorded. The prevalence of HK in all the renal nutrition visits was 26.1%; all but six cases were mild HK, whereas no severe HK was observed. The prevalence of HK was associated with decreased eGFR, up to 36.5% for eGFR < 20 ml/min. Medications were similar in hyperkalemic and normokalemic patients, RAASi being present in up to 85% of patients. In a follow-up of 40 ± 14 months, no association was found between HK and mortality, whereas HK, at the start of follow-up, showed a trend to increased ESRD risk. Serum potassium levels and prevalence of HK were not different between patients on animal-based low-protein diet and plant-based low-protein diet. In conclusion, chronic HK is quite prevalent in a renal nutrition clinic, especially when eGFR falls down below 60 ml/min, thereby reaching the highest prevalence in CKD stage 4. Hyperkalemia is mostly mild, being moderate to severe HK quite infrequent. Hyperkalemia was not associated with higher risk of mortality, whereas a trend, although not statistically significant, was observed for lower ESRD-free survival. Plant-based low-protein diet is not associated with significant higher prevalence of HK with respect to animal-based LPD at the same residual kidney function.
DOI : 10.1007/s11739-020-02353-9
Anahtar Kelimeler : CKD, Potassium, Hyperkalemia, Renal diets, Nutrition
ISSN: 1828-0447 1970-9366
Sayı: 1
Cilt: 16
Sayfa: 125-132

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