Piri Keşif Aracı

1

Concurrent occurrence of human and equine West Nile virus infections in Central Anatolia, Turkey: the first evidence for circulation of lineage 1 viruses

Araştırma Makalesi

Kaynak :

Aperta - TÜBİTAK Açık Arşivi

Dergi:

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Yazar(lar) :

Durdal Us , Mahur Turan , Sabri Hacioglu , Gurol Emekdas , Seda Tezcan , Ethem M Arsava , Feray Alkan , Aydan Koysuren , Koray Ergunay , Aykut Ozkul

Yıl :

2013

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

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Background: West Nile fever is an important zoonotic infection caused by West Nile virus (WNV), a member of the Flaviviridae. Previous serological data from Turkey suggest widespread WNV circulation. This report includes cases of human and equine WNV infections occurring concurrently, and manifesting as central nervous system infections, in two neighboring provinces of Central Anatolia, Turkey. A partial phylogenetic analysis of the causative virus is given for the first time.

DOI : 10.1016/j.ijid.2013.02.005

Sayi :17
issue :7
Sayfa :E546-E551

Sınıflandırma :

Biyotıp %100

Parazitoloji ve Enfeksiyon Hastalıkları %100

2

Evidence of vascular endothelial damage in Crimean-Congo hemorrhagic fever

Araştırma Makalesi

Kaynak :

Aperta - TÜBİTAK Açık Arşivi

Dergi:

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Yazar(lar) :

Bircan Unal Kayaaslan , Mustafa Gokhan Gozel , Bilkay Basturk , Yavuz Uyar , Pinar Onguru , Esragul Akinci , Hurrem Bodur

Yıl :

2010

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

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Background: Endothelial infection has an important role in the pathogenesis of Crimean-Congo hemorrhagic fever (CCHF). In this study, we investigated the causes of vascular endothelial damage in patients with CCHF.

DOI : 10.1016/j.ijid.2010.02.2240

Sayi :14
issue :8
Sayfa :E704-E707

Sınıflandırma :

Biyotıp %99

Viroloji %82

3

Reflections on the COVID-19 pandemic in the USA: Will we be better prepared next time?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Gonzalo Bearman , Rachel Pryor , Rebecca Vokes , Kaila Cooper , Michelle Doll , Emily J. Godbout , Michael P. Stevens

Yıl :

2020

International Journal of Infectious Diseases

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Ek Bilgiler

Kaydet

Cilt: 96
Sayfa: 610 - 613

Sınıflandırma :

Tıp ve Halk Sağlığı %48

4

Highlights from the 6th International Meeting on Emerging Diseases and Surveillance (IMED 2016) Vienna, Austria from Nov 3 to 7, 2016

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Britta Lassmann , Lawrence C. Madoff

Yıl :

2016

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2016.12.008

Cilt: 53
Sayı: S
Sayfa: 1 - 3

Sınıflandırma :

Biyotıp %29

Parazitoloji ve Enfeksiyon Hastalıkları %84

Tıp ve Halk Sağlığı %21

İmmünoloji %39

5

HIV-1 infection, but not syphilis or HBV infection, is a strong risk factor for anorectal condyloma in Asian population: A prospective colonoscopy screening study

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Takeshi Nishijima , Naoyoshi Nagata , Kazuhiro Watanabe , Katsunori Sekine , Shohei Tanaka , Yoshihiro Kishida , Tomonori Aoki , Yohei Hamada , Hirohisa Yazaki , Katsuji Teruya , Hiroyuki Gatanaga , Yoshimi Kikuchi , Toru Igari , Junichi Akiyama , Masashi Mizokami , Kazuma Fujimoto , Naomi Uemura , Shinichi Oka

Yıl :

2015

International Journal of Infectious Diseases

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Kaydet

Objective: To investigate the association between anorectal precancerous lesions, including condyloma, and sexually transmitted infections (STI) in Asian population. Methods: This prospective study enrolled 2677 patients who underwent high-resolution colonoscopy for anorectal cancer screening. Anorectal lesions were diagnosed based on endoscopic findings and confirmed by biopsy. The association of HIV-1 infection, syphilis, and HBV infection with anorectal lesion was estimated by multivariate logistic regression. In HIV-1-infected patients (n=244), anal canal HPV-DNA was screened and genotyped. Results: Although no malignancy was identified, anorectal condyloma was diagnosed in 32 (1.2%) male patients. 41% of anorectal condyloma cases had no specific lower GI symptoms. Multivariate analysis identified HIV-1 infection, but not syphilis or HBV infection, as an independent significant factor for condyloma (OR: 176.5, 95%CI 22.52-1383, p<0.001). In HIV-1 infected patients, positive type 16/18 HPV-DNA (OR: 4.766, 95%CI 1.838-12.36, p=0.001), lower CD4 cell count (per 100/μl decrement, OR: 1.056, 95%CI 1.056-1.587, p=0.013), and current smoking (OR: 3.828, 95%CI 1.486-9.857, p=0.005) were independently associated with anorectal condyloma. Conclusions: HIV-1 infection, but not syphilis or HBV infection, was identified as a strong risk for anorectal condyloma. Anal HPV 16/18 was highly prevalent in patients with HIV-1 infection, especially in those with condyloma.

DOI : 10.1016/j.ijid.2015.06.009

Anahtar Kelimeler : Screening anorectal precancerous lesions, Colonoscopy, Anorectal condyloma, Human papillomavirus, HIV-1 infection

Cilt: 37
Sayı: C
Sayfa: 70 - 76

6

Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV): Revision of screening strategies urgently needed

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Hala Amer , Abdulrahman S. Alqahtani , Faisal Alaklobi , Juhaina Altayeb , Ziad A. Memish

Yıl :

2018

International Journal of Infectious Diseases

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Kaydet

Objectives: Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause frequent hospital outbreaks in Saudi Arabia, with emergency departments as the initial site of the spread of this virus. Methods: The risk of transmission of MERS-CoV infection to healthcare workers (HCWs) was assessed in an outbreak in Riyadh. All HCWs with unprotected exposure to confirmed cases were tested after 24 h of exposure. Two negative results for MERS-CoV obtained 3 days apart and being free of any suggestive signs and symptoms were used to end the isolation of the HCWs and allow their return to duty. Results: Overall 17 out of 879 HCWS with different levels of exposure tested positive for MERS-CoV. Of the 15 positive HCWS with adequate follow-up, 40% (6/15 HCWs) tested positive on the first sampling and 53% (8/15) tested positive on the second sampling. The time to negative results among the 15 positive HCWs ranged between 4 and 47 days (average 14.5 days) and the infected HCWs needed on average two samples for clearance. All positive HCWs were either asymptomatic or had mild disease. Conclusions: The data obtained in this study support the widespread testing of all close contacts of MERS-CoV cases, regardless of the significance of the contact or presence or absence of symptoms. In addition, urgent careful review of guidance regarding the return of asymptomatic MERS-CoV-positive HCWs under investigation to active duty is needed.

DOI : 10.1016/j.ijid.2018.04.001

Anahtar Kelimeler : Screening, Quarantine, Isolation, Saudi Arabia, MERS-CoV

Cilt: 71
Sayı: C
Sayfa: 113 - 116

Sınıflandırma :

Tıp ve Halk Sağlığı %88

Acil servisler %100

7

Efficacy of empirical therapy with non-carbapenems for urinary tract infections with extended-spectrum beta-lactamase-producing Enterobacteriaceae

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Takanori Asakura , Masayuki Ikeda , Akira Nakamura , Satoshi Kodera

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

Objectives: Carbapenems are first-line agents for severe infections with extended-spectrum beta-lactamase (ESBL)-producing bacteria. The use of carbapenems, however, is associated with the emergence of resistant organisms. We investigated the effects of empirical therapy with non-carbapenems on urinary tract infections (UTIs) with ESBL-producing Enterobacteriaceae in a hospital where antimicrobial stewardship has been established. Methods: This retrospective chart review was undertaken at a tertiary care hospital where antimicrobial stewardship and restriction of carbapenems has been established. Patients with a UTI with ESBL-producing Enterobacteriaceae were stratified into susceptible and non-susceptible therapy groups according to the susceptibility of the causative organism to the initial antimicrobial therapy. Outcome measures were the duration of antimicrobial therapy, 14-day mortality, infection-related mortality, and clinical cure. Results: Of 90 patients, 30 (33.3%) exhibited susceptible therapy. However, no significant difference was observed in the duration of antimicrobial therapy, 14-day mortality, infection-related mortality, or clinical cure between the susceptible and non-susceptible groups. Multivariate analyses revealed that the independent risk factor for 14-day morality was the use of immunosuppressive agents (odds ratio 5.23, 95% confidence interval 1.26–24.04; p = 0.023). Conclusions: Non-carbapenem therapy against UTIs with ESBL-producing Enterobacteriaceae does not pose a significant risk to patients who are not taking immunosuppressive agents.

DOI : 10.1016/j.ijid.2014.08.018

Anahtar Kelimeler : Beta-lactamases, Urinary tract infections, Carbapenems, Cefmetazole, Cephamycins

Cilt: 29
Sayı: C
Sayfa: 91 - 95

Sınıflandırma :

Biyotıp %93

İlaç Direnci %100

8

Diphtheria immunity and serologic response after Td booster vaccination in Thai health care workers

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

S. Wiboonchutikul , W. Manosuthi , C. Sangsajja , V. Thientong , S. Likanonsakul , S. Srisopha , P. Termvises , J. Rujitip , S. Loiusirirotchanakul , P. Puthavathana

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2014.03.1273

Cilt: 21
Sayı: S1
Sayfa: 413

Sınıflandırma :

Tıp ve Halk Sağlığı %93

Aşı %100

9

Can smart phones be used for improving the timeliness of infectious disease reporting in rural South Africa? – The example of malaria

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

V.C. Quan , L. Blumberg , G. Kok , A. Hulth

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2014.03.969

Cilt: 21
Sayı: S1
Sayfa: 264

Sınıflandırma :

Biyotıp %82

Tropik ilaç %100

10

COVID-19: How to make between-country comparisons

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Rutger A. Middelburg , Frits R. Rosendaal

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Background: Different countries have adopted different containment and testing strategies for SARS-CoV-2. The difference in testing makes it difficult to compare the effect of different containment strategies. This study proposes methods to allow a direct comparison and presents the results. Design: Publicly available data on the numbers of reported COVID-19-related deaths between 01 January and 17 April 2020 were compared between countries. Results: The numbers of cases or deaths per 100,000 inhabitants gave severely biased comparisons between countries. Only the number of deaths expressed as a percentage of the number of deaths on day 25 after the first reported COVID-19-related death allowed a direct comparison between countries. From this comparison clear differences were observed between countries, associated with the timing of the implementation of containment measures. Conclusions: Comparisons between countries are only possible when simultaneously taking into account that the virus does not arrive in all countries simultaneously, absolute numbers are incomparable due to different population sizes, rates per 100,000 of the population are incomparable because not all countries are affected homogeneously, susceptibility to death by COVID-19 can differ between populations, and a death is only reported as a COVID-19-related death if the patient was diagnosed with SARS-CoV-2 infection. With the current methods, all these factors were accounted for and an unbiased direct comparison between countries was established. This comparison confirmed that early adoption of containment strategies is key in flattening the curve of the epidemic.

Anahtar Kelimeler : COVID-19, Forecast, Prevention, Mortality

Cilt: 96
Sayfa: 477 - 481

Sınıflandırma :

Tıp ve Halk Sağlığı %41

Adli Tıp %29

Bulaşıcı Hastalıklar %25

11

Carpal tunnel syndrome after chikungunya infection

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Marzia Puccioni-Sohler , Maria Cecília F. Salgado , Isadora Versiani , Carolina Rosadas , Fernando Ferry , Amilcar Tanuri , Orlando da Costa Ferreira Jr

Yıl :

2016

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2016.10.019

Cilt: 53
Sayı: C
Sayfa: 21 - 22

Sınıflandırma :

Tıp ve Halk Sağlığı %72

Parazitoloji %100

Biyotıp %27

Parazitoloji ve Enfeksiyon Hastalıkları %43

Viroloji %27

12

Clostridium difficile infection in University Hospital Trnava: A hospital-based survey

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

A. Streharova , M. Garabasova , M. Betkova , L. Macekova , J. Brnova

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2014.03.717

Cilt: 21
Sayı: S1
Sayfa: 140 - 141

Sınıflandırma :

Biyotıp %65

Epidemiyoloji %66

Tıp ve Halk Sağlığı %34

Bulaşıcı Hastalıklar %87

13

Global forecast of antimicrobial resistance in invasive isolates of Escherichia coli and Klebsiella pneumoniae

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Gerardo Alvarez-Uria , Sumanth Gandra , Siddhartha Mandal , Ramanan Laxminarayan

Yıl :

2018

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Objectives: To project future antimicrobial resistance (AMR) in Escherichia coli and Klebsiella pneumoniae. Methods: Mixed linear models were constructed from a sample of countries with AMR data in the ResistanceMap database. Inverse probability weighting methods were used to account for countries without AMR data. Results: The estimated prevalence of AMR in 2015 was 64.5% (95% confidence interval (CI) 42–87%) for third-generation cephalosporin-resistant (3GCR) Escherichia coli, 5.8% (95% CI 1.8–9.7%) for carbapenem-resistant (CR) E. coli, 66.9% (95% CI 47.1–86.8%) for 3GCR Klebsiella pneumoniae, and 23.4% (95% CI 7.4–39.4%) for CR K. pneumoniae. The projected AMR prevalence in 2030 was 77% (95% CI 55–99.1%) for 3GCR E. coli, 11.8% (95% CI 3.7–19.9%) for CR E. coli, 58.2% (95% CI 50.2–66.1%) for 3GCR K. pneumoniae, and 52.8% (95% CI 16.3–89.3%) for CR K. pneumoniae. Conclusions: The models suggest that third-generation cephalosporins and carbapenems could be ineffective against a sizeable proportion of infections by E. coli and K. pneumoniae in most parts of the world by 2030, supporting both the need to enhance stewardship efforts and to prioritize research and development of new antibiotics for resistant Enterobacteriaceae. Keywords: Drug resistance, Forecasting, Enterobacteriaceae infections, Regression

Cilt: 68
Sayfa: 50 - 53

Sınıflandırma :

Biyotıp %100

İlaç Direnci %100

14

Therapeutic drug monitoring: how to improve drug dosage and patient safety in tuberculosis treatment

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Giovanni Sotgiu , Jan-Willem C. Alffenaar , Rosella Centis , Lia Du2019Ambrosio , Antonio Spanevello , Andrea Piana , Giovanni Battista Migliori

Yıl :

2015

International Journal of Infectious Diseases

Yayıncı Web Sitesi

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Kaydet

In this article we describe the key role of tuberculosis (TB) treatment, the challenges (mainly the emergence of drug resistance), and the opportunities represented by the correct approach to drug dosage, based on the existing control and elimination strategies. In this context, the role and contribution of therapeutic drug monitoring (TDM) is discussed in detail. Treatment success in multidrug-resistant (MDR) TB cases is low (62%, with 7% failing or relapsing and 9% dying) and in extensively drug-resistant (XDR) TB cases is even lower (40%, with 22% failing or relapsing and 15% dying). The treatment of drug-resistant TB is also more expensive (exceeding €50 000 for MDR-TB and €160 000 for XDR-TB) and more toxic if compared to that prescribed for drug-susceptible TB. Appropriate dosing of first- and second-line anti-TB drugs can improve the patient's prognosis and lower treatment costs. TDM is based on the measurement of drug concentrations in blood samples collected at appropriate times and subsequent dose adjustment according to the target concentration. The ‘dried blood spot’ technique offers additional advantages, providing the rationale for discussions regarding a possible future network of selected, quality-controlled reference laboratories for the processing of dried blood spots of difficult-to-treat patients from reference TB clinics around the world.

DOI : 10.1016/j.ijid.2014.12.001

Anahtar Kelimeler : MDR-TB, XDR-TB, Prevention, Treatment, Therapeutic drug monitoring, Drug dosage

Cilt: 32
Sayı: C
Sayfa: 101 - 104

Sınıflandırma :

Biyotıp %61

İlaç Direnci %83

Tıp ve Halk Sağlığı %39

Farmakoterapi %83

15

Post-malarial anemia in Mozambican children treated with quinine or artesunate: A retrospective observational study

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Rosauro Varo , Llorenç Quintó , Antonio Sitoe , Lola Madrid , Sozinho Acácio , Pio Vitorino , Ana Marta Valente , Alfredo Mayor , Daniel Camprubí , Jose Muñoz , Gizela Bambo , Eusebio Macete , Clara Menéndez , Pedro L. Alonso , Pedro Aide , Quique Bassat

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Objectives: This retrospective analysis performed in Manhiça, Southern Mozambique, aimed to describe the frequency of post-malarial anemia (measured as a decrease of hematocrit ≥10%) and the need for blood transfusions in children with severe malaria treated with intravenous quinine or parenteral artesunate. Methods: All children <15 years admitted with a parasitologically-confirmed diagnosis of malaria from 1st January 2003 to 31st December 2017, alive at hospital discharge, and with at least one measurement of hematocrit within 28 days after hospital discharge, detected by passive case detection, were included. Results: The overall prevalence of post-malarial anemia observed in the study was 23.13%, with an estimated incidence rate of 288.84 episodes/1,000 children-month at risk in the follow-up period (28 days after discharge). There were no differences between treatment groups, although the study showed a higher association between blood transfusions and artesunate treatment. Conclusions: In this setting, children with severe malaria frequently present a meaningful decrease of hematocrit (>=10%) in the first weeks after their episode, sometimes requiring blood transfusions. Because of the high underlying prevalence of anemia in malaria-endemic settings, all children with severe malaria need to be actively followed up, irrespective of the treatment received.

Anahtar Kelimeler : Severe malaria, Anemia, Hemolysis, Artesunate, Quinine, African children

Cilt: 96
Sayfa: 655 - 662

16

Is a highly pathogenic avian influenza virus H5N1 fragment recombined in PB1 the key for the epidemic of the novel AIV H7N9 in China, 2013?

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Liang Chen , Liqian Sun , Rui Li , Yue Chen , Zhijie Zhang , Chenglong Xiong , Genming Zhao , Qingwu Jiang

Yıl :

2016

International Journal of Infectious Diseases

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Kaydet

Background: A novel avian influenza A H7N9 virus that infects humans was identified in China in 2013. This study is the first to comprehensively investigate the characteristics of genomic recombination, rather than reassortment, which has been the subject of investigation in previously reported studies. Methods: Novel avian influenza virus (AIV) H7N9 genome sequences were obtained from the NCBI Influenza Virus Sequence Database and the Global Initiative on Sharing Avian Influenza Database (GISAID) and a representative isolate was subjected to homogeneity analysis. A phylogenetic tree was constructed. Eight segments of the isolate were analyzed to identify segments with recombination events, the corresponding recombination fragments, and breakpoints. The evolutionary history of the recombined fragments was tracked by constructing phylogenetic trees of the recombination fragments. Results: Among the eight segments of the novel AIV H7N9 analyzed, only the PB1 segment showed a marked recombination phenomenon, with 11 recombination events; these included five actual recombination events and six possible misalignment artifact recombination events. The most notable was the recombination of a 291-nucleotide (nt) fragment at the 490–780 nt site that was affiliated to a highly pathogenic avian influenza virus (HPAIV) H5N1 (A/tree sparrow/Thailand/VSMU-16-RBR/2005). The phylogenetic tree of the 291-nt recombination fragment on the PB1 segment showed that the novel AIV H7N9 had a close genetic relationship to H9N2 and H5N1. Conclusions: The novel AIV H7N9 might have reassorted its PB1 segment from H9N2 circulating in China, and this H9N2 PB1 might have been recombined into a highly pathogenic fragment from HPAIV H5N1, which could be the reason for the high fatality rate among patients with AIV H7N9 influenza.

DOI : 10.1016/j.ijid.2016.01.002

Anahtar Kelimeler : Influenza virus, Recombination, China

Cilt: 43
Sayı: C
Sayfa: 85 - 89

Sınıflandırma :

Biyotıp %98

Viroloji %100

17

Cryptococcal meningitis burden in immunocompromised hosts, as seen in a neurological setup, India

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

R. kumar. R , E. Jyothi

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2014.03.1015

Cilt: 21
Sayı: S1
Sayfa: 287

Sınıflandırma :

Biyotıp %100

Antikorlar %19

18

Accelerating reductions in antimicrobial resistance: Evaluating the effectiveness of an intervention program implemented by an infectious disease consultant

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Naoki Kishida , Hiroshi Nishiura

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Objectives: Very few infectious disease physicians exist in Japan. A concerted infection control intervention program involving an antimicrobial stewardship team and multiple components was designed and implemented in multiple hospitals from 2010. Here, we aimed to retrospectively evaluate the intervention program’s effectiveness. Methods: The frequencies of methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant Pseudomonas aeruginosa were monitored in four acute-care hospitals. The primary goal of the program was to accelerate the speed of decline of such resistance. A quasi-experimental study design was used to detect accelerated rates of increases in drug susceptibility, comparing time before and after the intervention. Results: Both MRSA and drug-resistant P. aeruginosa exhibited decreasing trends (p < 0.01 for all four hospitals and all bacterial cultures). Compared with the whole of Japan, the decreasing trends for MRSA and drug-resistant P. aeruginosa in the four hospitals accelerated after the intervention program was established; notably, the rate of MRSA decrease increased by 50%–150% of its original value. Conclusions: The intervention program successfully reduced the proportion of drug resistance in the four hospitals. Centering on systematic education, decision-making support, and implementation and oversight by an infectious disease consultant, this program was shown to be effective where specialist physicians are scarce. Keywords: Nosocomial infection, Drug utilization, Drug resistance, Infection control practitioners, Training programs

Cilt: 93
Sayfa: 175 - 181

19

Viral load and dendritic cells from vertically HIV-infected children and adolescents

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

J.S. Bernachi , T. Mazzola , A.L. Longhini , E.B.V. Anjos , L.G.R. Fernandes , T. Oshiro , R. Lemos , M.T.N. da Silva , M.M.D.S. Vilela

Yıl :

2014

International Journal of Infectious Diseases

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Kaydet

DOI : 10.1016/j.ijid.2014.03.1030

Cilt: 21
Sayı: S1
Sayfa: 294 - 295

Sınıflandırma :

Biyotıp %95

Viroloji %85

20

Applications of Google Search Trends for risk communication in infectious disease management: A case study of the COVID-19 outbreak in Taiwan

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Atina Husnayain , Anis Fuad , Emily Chia-Yu Su

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Objective: An emerging outbreak of a novel coronavirus, COVID-19, has now been detected in at least 211 countries worldwide. Given this pandemic situation, robust risk communication is urgently needed, particularly in affected countries. Therefore, this study explored the potential use of Google Trends (GT) to monitor public restlessness toward COVID-19 infection in Taiwan. Methods: We retrieved GT data for the specific locations and subregions in Taiwan nationwide using defined search terms related to the coronavirus, handwashing, and face masks. Results: Searches related to COVID-19 and face masks in Taiwan rapidly increased following the announcements of Taiwan's first imported case and reached a peak as locally acquired cases were reported. However, searches for handwashing gradually increased during the period of face-mask shortage. Moreover, high to moderate correlations between Google relative search volumes (RSVs) and COVID-19 cases were found in Taipei (lag-3), New Taipei (lag-2), Taoyuan (lag-2), Tainan (lag-1), Taichung (lag0), and Kaohsiung (lag0). Conclusion: In response to the ongoing outbreak, our results demonstrated that GT could potentially define the proper timing and location for practicing appropriate risk communication strategies for affected populations.

Anahtar Kelimeler : Google Trends, Risk communication, COVID-19, Taiwan

Cilt: 95
Sayfa: 221 - 223

Sınıflandırma :

Tıp ve Halk Sağlığı %74

Halk Sağlığı %37

Bulaşıcı Hastalıklar %25

21

BCG vaccination following latent TB treatment: Possible implications for different settings

Dergi Makalesi

Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

L. Goscé , J. Bitencourt , R.K. Gupta , S. Arruda , L.C. Rodrigues , I. Abubakar

Yıl :

2019

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Despite much progress globally, TB is still one of the top 10 causes of death worldwide. Several studies have shown the importance of implementing different preventive strategies alongside treatment of TB disease, including BCG vaccination and treatment of latent tuberculosis infection (LTBI). Large-scale population level LTBI treatment is not currently part of WHO guidelines which recommend LTBI treatment only to high risk populations. Moreover, BCG has been widely used in the past decades to both prevent infection with M. tuberculosis and reduce rates of reactivation. In this viewpoint we discuss the hypothesis of BCG vaccination following latent TB treatment and its potential impact across different settings. Keywords: Latent TB, BCG, Vaccination

Cilt: 80
Sayfa: S17 - S19

Sınıflandırma :

Tıp ve Halk Sağlığı %92

Bulaşıcı Hastalıklar %53

Aşı %25

Gastroenteroloji %21

22

Influence of pneumococcal vaccination on the hospitalization of healthy pediatric patients due to typical Community-Acquired Pneumonia

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Ana Isabel Valdivielso Martínez , Jose Miguel Ramos Fernández , Javier Pérez Frías , David Moreno Pérez

Yıl :

2020

International Journal of Infectious Diseases

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Introduction: Community-Acquired Pneumonia (CAP) is one of the most frequent causes of hospital admission in children. Our objective is to measure the impact of the introduction of pneumococcal conjugate vaccines on the hospitalization of previously healthy children due to CAP. Method: From 2011 to 2016, a partially retrospective, prospective, and descriptive study was carried out on healthy pediatric patients (3 months–14 years old) with CAP, who required hospital admission. Clinical, epidemiological, and demographic characteristics were collected, and vaccination status was obtained from medical records. Results: A total of 292 cases were included, with a mean age of 33.4 months, 54% males. There was a progressive and significant 42% decrease in the number of admissions each year, without significant changes in the annual percentage of parapneumonic pleural effusion (PPE). Fifty-six percent of patients were immunized with a pneumococcal conjugate vaccine (PCV). The percentage of children who were not vaccinated decreased by 14%, and the coverage with PCV-13 increased by 46%. This revealed a significant increase of PPE in vaccinated patients with PCV-7 (63%) compared with unvaccinated (45%) and with PCV-13 (57%), without association with the presence of severe PPE. Moreover, no significant differences in severity or hospital stay were observed in unvaccinated patients, compared to those who were vaccinated. In >2-year-olds, we observed a significant increase in PPE (59%) compared to 45% in younger children. Conclusions: The increase in vaccination coverage with PCV-13 resulted in a decrease in hospitalizations due to CAP and PPE. Vaccination with PCV-7 is associated in our sample with an increase in PPE but not with severe PPE nor an increase in the hospital stay. There was an epidemiological shift of severe forms of pneumonia and empyema at later ages (>2 years).

Anahtar Kelimeler : Pneumococcal conjugates vaccines, Pneumonia in children

Cilt: 98
Sayfa: 194 - 199

Sınıflandırma :

Tıp ve Halk Sağlığı %100

Bulaşıcı Hastalıklar %46

23

Comparison of USA300 with non-USA300 methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Takemi Murai , Kaoru Okazaki , Kazue Kinoshita , Yuki Uehara , Hui Zuo , Yujie Lu , Yuki Ono , Takashi Sasaki , Keiichi Hiramatsu , Yuho Horikoshi

Yıl :

2019

International Journal of Infectious Diseases

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Özet Ek Bilgiler

Kaydet

Objectives: Reports of USA300 methicillin-resistant Staphylococcus aureus (MRSA) strain were still scarce in neonatal intensive care units (NICUs) and the relationship of USA300 MRSA to clinical infections is still controversial. The primary outcome was the incidence of MRSA infections caused by the USA300 and non-USA300 strains at a NICU in Japan. Methods: This retrospective cohort study was conducted between November 2011 and October 2016 at Tokyo Metropolitan Children’s Medical Center in Japan. All MRSA isolated after 48 h of hospitalization were included for analysis by pulsed-field gel electrophoresis (PFGE) using the standard USA300 strain. Genes were tested for Panton-Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME). A whole genome sequence was performed for representative isolates of USA300. Results: In total, 109 MRSA isolates were included for analysis. PFGE classified 34 and 75 isolates of USA300 and non-USA300 MRSA, respectively. Both PVL and ACME genes were detected in USA300 and non-USA300 strains at rate of 100% (34/34) and 5.3% (4/75), respectively (P < 0.05). There was no statistically significant difference in the proportion of clinical diseases between USA- 300 and non-USA 300 strains. Conclusions: Infants with USA300 MRSA infection did not differ significantly from those with non-USA300 MRSA infection. Keywords: Methicillin-resistant Staphylococcus aureus, Neonatal intensive care unit, USA300, Panton-Valentine leukocidin, Arginine catabolic mobile element

Cilt: 79
Sayfa: 134 - 138

24

Discovery and development of safe-in-man broad-spectrum antiviral agents

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Petter I. Andersen , Aleksandr Ianevski , Hilde Lysvand , Astra Vitkauskiene , Valentyn Oksenych , Magnar Bjørås , Kaidi Telling , Irja Lutsar , Uga Dumpis , Yasuhiko Irie , Tanel Tenson , Anu Kantele , Denis E. Kainov

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Özet Ek Bilgiler

Kaydet

Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. Keywords: Virus, Antiviral drug, Drug discovery and development, Broad-spectrum antiviral agents, BSAAs

Cilt: 93
Sayfa: 268 - 276

Sınıflandırma :

Biyotıp %98

Parazitoloji ve Enfeksiyon Hastalıkları %41

Viroloji %41

25

Neisseria meningitidis inside neutrophils, revealing properdin deficiency

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Benjamin Gillet , Nicolas Joram , Véronique Frémeaux Bacchi , Caroline Thomas , Marie C. Béné , Soraya Wuillème

Yıl :

2020

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Ek Bilgiler

Kaydet

Anahtar Kelimeler : Complement alternative pathway, Neisseria spp., X-linked disorder

Cilt: 99
Sayfa: 117 - 118

Sınıflandırma :

Biyotıp %99

Epidemiyoloji %96

26

Clostridioides difficile infection in immunocompromised hospitalized patients is associated with a high recurrence rate

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Tomer Avni , Tanya Babitch , Haim Ben-Zvi , Rabab Hijazi , Gida Ayada , Alaa Atamna , Jihad Bishara

Yıl :

2020

International Journal of Infectious Diseases

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Özet Ek Bilgiler

Kaydet

Objective: Clostridioides difficile infection (CDI) may pose a serious threat to immunocompromised patients (IMC). Herein, we evaluated the clinical outcomes of IMC patients with CDI. Methods: All consecutive hospitalized patients between January 1, 2013 and December 31, 2018 with laboratory confirmed CDI were included in the study. Subjects were divided into two groups: IMC patients and controls. Primary outcome was the recurrence rate of CDI (rCDI) at 30 and 90 days after the first CDI episode. Secondary outcomes included 30 and 90 day all-cause mortality, length of hospital stay (LOS) and readmission rates. A multivariate analysis adjusted other risk factors for recurrence. An analysis of IMC patient subgroups (based on type of IMC conditions) was also performed. Results are reported as odds ratios (OR) with a 95% confidence interval (95% CI). Results: A total of 573 patients were included, amongst them 149 IMC patients (36 solid organ transplants, 38 undergoing chemotherapy, 62 haematological conditions, 13 receiving high dose prednisone) and 424 controls. IMC patients were younger, independent and exhibited less significant comorbidities. On multivariable analysis, the rate of rCDI was significantly higher in IMC patients (OR 2.7, 95% CI 1.6–5). rCDI was also associated with vancomycin therapy, haemodialysis and previous hospitalizations. Mortality, LOS, CDI complications and rehospitalization rates were similar in both. Conclusions: IMC patients with CDI have an increased risk of 90 days rCDI. Vancomycin treatment for CDI endangers recurrence in IMC patients. Further research should explore other therapies for IMC patients with CDI with alternative agents such as Fidaxomicin and Bezlotoxumab. Keywords: Clostridioides difficile, Immunocompromised, Chemotherapy, Transplantations, Recurrence

Cilt: 90
Sayfa: 237 - 242

Sınıflandırma :

Tıp ve Halk Sağlığı %96

Bulaşıcı Hastalıklar %100

27

Prevalence, molecular epidemiology and intra-hospital acquisition of Klebsiella pneumoniae strains producing carbapenemases in an Italian teaching hospital from January 2015 to September 2016

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Kaynak :

Directory of Open Access Journals (DOAJ)

Dergi:

International Journal of Infectious Diseases

Yazar(lar) :

Andrea Bartolini , Monica Basso , Elisa Franchin , Nicola Menegotto , Anna Ferrari , Ettore De Canale , Samantha Andreis , Renzo Scaggiante , Stefania Stefani , Giorgio Palù , Saverio Giuseppe Parisi

Yıl :

2017

International Journal of Infectious Diseases

Yayıncı Web Sitesi

Piri Tam Metin Bulucu Özet Ek Bilgiler

Kaydet

Objectives: We described Klebsiella pneumoniae producing carbapenemase (CPKP) spread from 01/01/2015 to 13/09/16 in a tertiary level hospital. Methods: The first positive surveillance rectal swab (SRS) or clinical sample (CS) collected in the medical department (MD), surgical department (SD) and intensive care department (ICD) were included in the study. A validated in-house Real-Time PCR method was used to detect carbapenemases; multilocus sequence typing (MLST) was used for further characterization of the strains. Results: 21535 patients were included: 213 CPKP strains from surveillance rectal swab (SRS) and 98 from clinical samples (CS) were collected. The percentage of CPKP detected in SRS with respect to CS increased in the medical MD from 2015 to 2016 (p = 0.01) and in ICD from 2012 to 2015 (p = 0.0001), while it decreased in SD from 2014 to 2016 (p = 0.003); 68.5% of the positive SRS had a previous negative SRS; CPKP was more frequently identified in CS than in SRS in MD. Twelve strains harboured more than one carbapenemase gene. Many other species harbouring a carbapenemase gene were collected. Conclusions: MDs need more inclusive surveillance criteria. The late detection of positive SRS underlined the risk of colonization during hospitalization.

DOI : 10.1016/j.ijid.2017.04.007

Anahtar Kelimeler : carbapenemases, Klebsiella pneumoniae, colistin, longitudinal survey, multilocus sequence typing

Cilt: 59
Sayı: C
Sayfa: 103 - 109

Sınıflandırma :

Biyotıp %99

Viroloji %51

İlaç Direnci %27

28

Study of herbal bioenhancers on various characteristics of isoniazid and rifampicin microspheres

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Kaynak :

Directory of Open Access Journals (DOAJ)