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1
CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
JSTOR
Kaynak 2:
JSTOR
Kaynak 3:
JSTOR
Kaynak 4:
JSTOR
Kaynak 5:
JSTOR
Dergi:
Viruses
Yazar(lar) :
Shuliang Chen , Xiao Yu , Deyin Guo
Yıl :
2018
Viruses
Kaydet Alıntıla
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy.
Yayın Tarihi: 2018-01-16
2
CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Viruses
Yazar(lar) :
Shuliang Chen , Xiao Yu , Deyin Guo
Yıl :
2018
Viruses
Yayıncı Web Sitesi
Kaydet Alıntıla
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy.
Yayın Tarihi: 2018-01-16
3
Influenza and respiratory syncytial virus are the major respiratory viruses detected from prospective testing of pediatric and adult coronial autopsies
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
JSTOR
Kaynak 2:
JSTOR
Kaynak 3:
JSTOR
Kaynak 4:
JSTOR
Kaynak 5:
JSTOR
Dergi:
Influenza and Other Respiratory Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Daniel M. Moss , David J. Speers , David W. Smith , Avram Levy , Cara Minneyu2010Smith
Yıl :
2013
Influenza and Other Respiratory Viruses
Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1111/irv.12139
Cilt: 7
Sayı: 6
Sayfa: 1113-1121
Yayın Tarihi: 2013-11-01
4
Influenza and respiratory syncytial virus are the major respiratory viruses detected from prospective testing of pediatric and adult coronial autopsies
Dergi Makalesi

Dergi Makalesi
Kaynak :
JSTOR
Dergi:
Influenza and Other Respiratory Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Daniel M. Moss , David J. Speers , David W. Smith , Avram Levy , Cara Minneyu2010Smith
Yıl :
2013
Influenza and Other Respiratory Viruses
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1111/irv.12139
Cilt: 7
Sayı: 6
Sayfa: 1113-1121
Yayın Tarihi: 2013-11-01
5
Co-Delivery Effect of CD24 on the Immunogenicity and Lethal Challenge Protection of a DNA Vector Expressing Nucleocapsid Protein of Crimean Congo Hemorrhagic Fever Virus
Araştırma Makalesi

Araştırma Makalesi
Open Access
Kaynak :
Aperta - TÜBİTAK Açık Arşivi
Dergi:
VIRUSES-BASEL
Yazar(lar) :
Aykut Ozkul , Hiba Hashim Mohamed Ali , Erkan Yilmaz , Koray Ergunay , Katalin Foldes , Alireza Hanifehnezhad , Touraj Aligholipour Farzani
Yıl :
2019
VIRUSES-BASEL
Yayıncı Web Sitesi
 Piri Tam Metin Bulucu
Kaydet Alıntıla
Crimean Congo hemorrhagic fever virus (CCHFV) is the causative agent of a globally-spread tick-borne zoonotic infection, with an eminent risk of fatal human disease. The imminent public health threat posed by the disseminated virus activity and lack of an approved therapeutic make CCHFV an urgent target for vaccine development. We described the construction of a DNA vector expressing a nucleocapsid protein (N) of CCHFV (pV-N13), and investigated its potential to stimulate the cytokine and total/specific antibody responses in BALB/c and a challenge experiment in IFNAR(-/-) mice. Because of a lack of sufficient antibody stimulation towards the N protein, we have selected cluster of differentiation 24 (CD24) protein as a potential adjuvant, which has a proliferative effect on B and T cells. Overall, our N expressing construct, when administered solely or in combination with the pCD24 vector, elicited significant cellular and humoral responses in BALB/c, despite variations in the particular cytokines and total antibodies. However, the stimulated antibodies produced as a result of the N protein expression have shown no neutralizing ability in the virus neutralization assay. Furthermore, the challenge experiments revealed the protection potential of the N expressing construct in an IFNAR (-/-) mice model. The cytokine analysis in the IFNAR(-/-) mice showed an elevation in the IL-6 and TNF-alpha levels. In conclusion, we have shown that targeting the S segment of CCHFV can be considered for a practical way to develop a vaccine against this virus, because of its ability to induce an immune response, which leads to protection in the challenge assays in the interferon (IFN)-gamma defective mice models. Moreover, CD24 has a prominent immunologic effect when it co-delivers with a suitable foreign gene expressing vector.
DOI : 10.3390/v11010075
Sayi :11
issue :1
Sınıflandırma :
Biyotıp %100
Viroloji %100
6
Do Viral Proteins Possess Unique Features?
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Bin Xue , Robert W. Williams , Christopher J. Oldfield , Gerard K.-M. Goh , A. Keith Dunker , Vladimir N. Uversky
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionClassification and Functions of Viral ProteinssIntrinsic Disorder in Viral ProteinsFunctionality of Intrinsic Disorder in Viral ProteinsIntrinsic Disorder, Alternative Splicing, and Overlapping Reading Frames in Viral GenomesConcluding RemarksAcknowledgmentAbbreviationsReferences
DOI : 10.1002/9781118135570.ch1
ISBN:9780470618318
Sayfa: 1-34
7
Structural Disorder in Proteins of the Rhabdoviridae Replication Complex
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Cédric Leyrat , Francine C. A. Gérard , Euripedes A. Ribeiro , Ivan Ivanov , Marc Jamin
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionThe Rhabdovirus Replication ComplexA Meta‐Prediction of Protein Disordered RegionsThe Modular Organization of Rhabdovirus PhosphoproteinFlexible Loops in N Participate in Binding PRoles of Disorder in the Rhabdovirus Transcription/Replication ComplexAcknowledgmentsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch5
ISBN:9780470618318
Sayfa: 115-141
8
Intrinsic Disorder in Genome-Linked Viral Proteins VPgs of Potyviruses
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Jadwiga Chroboczek , Eugénie Hébrard , Kristiina Mäkinen , Thierry Michon , Kimmo Rantalainen
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionExperimental Probing of Intrinsic Disorder in Potyviral VPgsInteraction of PVA VPg with LipidsLMV VPg Disorder‐to‐Order Transition Upon eIF4E BindingIs Intrinsic Disorder a Common Feature of VPg? An In Silico Comparative StudyConclusionsAcknowledgmentsList Of VirusesAbbreviationsReferences
DOI : 10.1002/9781118135570.ch11
ISBN:9780470618318
Sayfa: 277-312
9
Structural Disorder in Proteins from Influenza Virus
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Gerard K.-M. Goh , Bin Xue , A. K. Dunker , Vladimir N. Uversky
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionIntroducing Influenza VirusPredicted Intrinsic Disorder in Influenza VirusIntrinsic Disorder of Viral Proteins and Viral InfectivityDisorder in the 1918 H1N1 and H5N1 VirusesConcluding RemarksAcknowledgementsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch7
ISBN:9780470618318
Sayfa: 169-200
10
Intrinsically Disordered Domains of Sesbania Mosaic Virus Encoded Proteins
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Smita Nair , M. R. N. Murthy , H. S. Savithri
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionBioinformatic Analysis of Intrinsically Disordered Domains of SeMV‐Encoded ProteinsIntrinsically Disordered VPg Modulates the Protease FunctionIntrinsically Disordered, Nucleic‐Acid‐Binding P8 Domain Activates P10 AtpaseIntrinsically Disordered Segment of SeMV CP Controls AssemblyAcknowledgmentsAbbreviationsList Of VirusesReferences
DOI : 10.1002/9781118135570.ch10
ISBN:9780470618318
Sayfa: 257-276
11
Bacteriophage λ N Protein Disorder-Order Transitions upon Interactions with RNA or Proteins
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Kristian Schweimer , Paul Rösch
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionThe Antitermination ComplexAntitermination Protein NThe λN–RNA InteractionNusA–λN InteractionConcluding RemarksReferences
DOI : 10.1002/9781118135570.ch16
ISBN:9780470618318
Sayfa: 425-444
12
Live attenuated H5N1 vaccine with H9N2 internal genes protects chickens from infections by both Highly Pathogenic H5N1 and H9N2 Influenza Viruses
Dergi Makalesi

Dergi Makalesi
Kaynak 1:
JSTOR
Kaynak 2:
JSTOR
Kaynak 3:
JSTOR
Kaynak 4:
JSTOR
Kaynak 5:
JSTOR
Kaynak 6:
JSTOR
Dergi:
Influenza and Other Respiratory Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Nguyen Tai Nang , Hyun Soo Kim , Sang Heui Seo , Heui Man Kim , Young Myong Kang , Byung Min Song
Yıl :
2013
Influenza and Other Respiratory Viruses
Piri Tam Metin Bulucu
Kaydet Alıntıla
DOI : 10.1111/j.1750-2659.2012.00363.x
Cilt: 7
Sayı: 2
Sayfa: 120-131
Yayın Tarihi: 2013-03-01
13
Intrinsic Disorder in the Human Papillomavirus E7 Protein
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Lucía B. Chemes , Ignacio E. Sánchez , Leonardo G. Alonso , Gonzalo de Prat-Gay
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionThe Papillomavirus E7 OncoproteinHPV16 E7: Conformational Equilibria and StructureConformational Diversity of the E7 Protein In VivoE7N is a Bona Fide IDDInteraction Mechanisms of HPV16 E7Evolution of the E7 Papillomavirus ProteinConcluding RemarksAcknowledgmentsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch12
ISBN:9780470618318
Sayfa: 313-346
14
The NS5A Domain II of HCV: Conservation of Intrinsic Disorder in Several Genotypes
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Xavier Hanoulle , Isabelle Huvent , Arnaud Leroy , Hong Ye , Cong Bao Kang , Yu Liang , Claire Rosnoblet , Jean-Michel Wieruszeski , Ho Sup Yoon , Guy Lippens
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: THE NS5A Domain II in the HCV Replicative CyclePrimary Sequence Information Over the Different GenotypesDisorder Predictions Over the Different GenotypesMacroscopic Methods to Evaluate Structure: Gel Filtration and CDNMR Spectroscopy of the NS5A D2 DomainsConclusionsAcknowledgementsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch15
ISBN:9780470618318
Sayfa: 409-424
15
Core-Lations Between Intrinsic Disorder and Multifaceted Activities in Hepatitis C Virus and Related Viruses
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Roland Ivanyi-Nagy , Eve-Isabelle Pécheur , Jean-Luc Darlix
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: The Flaviviridae Family of RNA VirusesThe Core Protein of Hepatitis C VirusStructure and Disorder in the Core Proteins of Flavi‐ And PestivirusesAcknowledgmentsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch14
ISBN:9780470618318
Sayfa: 375-407
16
N-Terminal Extension Region of Hordeivirus Movement TGB1 Protein Consists of Two Domains with Different Content of Disordered Structure
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yazar(lar) :
Valentin V. Makarov , Michael E. Taliansky , Eugeny N. Dobrov , Natalia O. Kalinina
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
This chapter contains sections titled: IntroductionSecondary Structure Predictions for PSLV TGBP1Spontaneous Limited Proteolysis of the Recombinant PSLV TGBP1 in Escherichia coliCD and FTIR Spectra of the Recombinant Proteins Corresponding to the N‐Terminal Extension Region (N63K) and Predicted Domains NTD and IDNTD and N63K as Intrinsically Disordered PolypeptidesID is Mostly Disordered with Order‐Prone SegmentsProperties of NTD, ID and N63K Studied by Dynamic Laser Light Scattering (DLS) and Atomic Force Microscopy (AFM)Structural Organization of the TGB1 N‐Terminal Extention Regions of Other Viruses With Hordei‐Like TGBRelationship between Structure of TGB1 Movement Proteins and their Function in Virus Transport in PlantsAcknowledgementsAbbreviationsReferences
DOI : 10.1002/9781118135570.ch17
ISBN:9780470618318
Sayfa: 445-471
17
Frontmatter
Kitap Bölümü

Kitap Bölümü
Kaynak :
Wiley Online Library
Dergi:
Flexible Viruses
Yayıncı:
John Wiley & Sons, Inc.
Yıl :
2011
Flexible Viruses
Yayıncı Web Sitesi
Tam Metin
Kaydet Alıntıla
The prelims comprise: Half TitleWiley Series PageTitleCopyrightContentsPrefaceIntroduction to the Wiley Series on Protein and Peptide ScienceContributors
DOI : 10.1002/9781118135570.fmatter
ISBN:9780470618318
Sayfa: i-xxi

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