Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

Yayıncı:

Nutrients

Yazar(lar):

Hamid A. Bakshi , Mazhar S Al Zoubi , Hakkim L. Faruck , Alaa A A Aljabali , Firas A. Rabi , Amin A. Hafiz , Khalid M Al-Batanyeh , Bahaa Al-Trad , Prawej Ansari , Mohamed M. Nasef , Nitin B. Charbe , Saurabh Satija , Meenu Mehta , Vijay Mishra , Gaurav Gupta , Salem Abobaker , Poonam Negi , Ibrahim M. Azzouz , Ashref Ali K Dardouri , Harish Dureja , Parteek Prasher , Dinesh K. Chellappan , Kamal Dua , Mateus Webba Da Silva , Mohamed El Tanani , Paul A. McCarron , Murtaza M. Tambuwala

Yayın Yılı:

2020

Yayın Türü:

Dergi Makalesi

Veritabanı:

Directory of Open Access Journals (DOAJ)

Doi

10.3390/nu12061901

Sınıflandırma

Biyotıp %100

Özet

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

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