Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage


Yayıncı:
Yazar(lar):
Hamid A. Bakshi
,
Mazhar S Al Zoubi
,
Hakkim L. Faruck
,
Alaa A A Aljabali
,
Firas A. Rabi
,
Amin A. Hafiz
,
Khalid M Al-Batanyeh
,
Bahaa Al-Trad
,
Prawej Ansari
,
Mohamed M. Nasef
,
Nitin B. Charbe
,
Saurabh Satija
,
Meenu Mehta
,
Vijay Mishra
,
Gaurav Gupta
,
Salem Abobaker
,
Poonam Negi
,
Ibrahim M. Azzouz
,
Ashref Ali K Dardouri
,
Harish Dureja
,
Parteek Prasher
,
Dinesh K. Chellappan
,
Kamal Dua
,
Mateus Webba Da Silva
,
Mohamed El Tanani
,
Paul A. McCarron
,
Murtaza M. Tambuwala
Yayın Yılı:
2020
Yayın Türü:
Dergi Makalesi
Veritabanı:
Directory of Open Access Journals (DOAJ)
Doi
10.3390/nu12061901
Özet
Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
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